Achromobacter bacteriophage cocktails and methods of use thereof

Abstract

The present disclosure generally relates to a bacteriophages, combinations of bacteriophages, or pharmaceutical compositions thereof useful in the treatment of subjects afflicted with Achromobacter infection. The present disclosure also provides methods of treating subjects, e.g., subjects afflicted with Achromobacter infection, by administration of bacteriophages, combinations of bacteriophages, or pharmaceutical compositions thereof.

Description

ACHROMOBACTER BACTERIOPHAGE COCKTAILS AND METHODS OF USE THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims the benefit of and priority to U.S. Provisional Application No.63 / 551,252 filed on February 8, 2024, the disclosure of which is hereby incorporated by reference in its entirety for all purposes. SEQUENCE LISTING

[0002] The present application contains a Sequence Listing XML, which has been submitted electronically and is hereby incorporated by reference in its entirety. Said XML copy, created on January 24, 2025, is named UPB-028WO_SL.xml, and is 273,804 bytes in size. FIELD OF THE DISCLOSURE

[0003] The invention relates to variants of Achromobacter bacteriophages, pharmaceutical compositions, and therapeutic methods useful for the treatment of Achromobacter infections. STATEMENT REGARDING SPONSORED RESEARCH OR DEVELOPMENT

[0004] Research for this invention was supported by awards from the Cystic Fibrosis Foundation. BACKGROUND

[0005] Despite recent advances in antimicrobial therapies, multidrug-resistant organisms (MDROs), such as Achromobacter, continue to cause serious and life-threatening infections in people with cystic fibrosis (CF). Achromobacter species cause decline in lung function, exacerbations, post-transplant airway complications, and death in persons with cystic fibrosis (CF). Unfortunately, Achromobacter spp. are often extensively drug-resistant due to a wide range of resistance mechanisms. Thus, there remains a need for therapeutic interventions which target Achromobacter spp., for example, in people with CF. SUMMARY

[0006] Disclosed herein, in various embodiments, are pharmaceutical compositions comprising various strains of Achromobacter phage. Disclosed pharmaceutical compositions can be used, for example, to treat patients having or suspected of having Achromobacterinfections, e.g., antibiotic-resistant Achromobacter infections. In certain embodiments, pharmaceutical compositions disclosed herein are effective against infections from a wide range of Achromobacter species.

[0007] Disclosed herein, in various embodiments, is a pharmaceutical composition comprising one or more strains of Achromobacter phage and a pharmaceutically acceptable carrier, wherein the strains of Achromobacter phage are each selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. In some embodiments, the composition comprises two or more genetically distinct strains of Achromobacter phage, each strain selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. In some embodiments, the composition comprises three or more genetically distinct strains of Achromobacter phage, each strain selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. In some embodiments, the composition comprises four or more genetically distinct strains of Achromobacter phage, each strain selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. In some embodiments, the composition comprises the phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07 strains of Achromobacter phage.

[0008] In some embodiments, the composition comprises about 5×105pfu / mL to about 5×1012pfu / mL of Achromobacter phage. In some embodiments, the composition comprises about 5×107pfu / mL to about 5×109pfu / mL of Achromobacter phage. In some embodiments, the composition comprises about 5×107pfu / mL, about 5×108pfu / mL, or about 5×109pfu / mL of Achromobacter phage. In some embodiments, the composition comprises about 5×108pfu / mL of Achromobacter phage.

[0009] In some embodiments, the composition further comprises a pharmaceutically acceptable excipient. In some embodiments, the composition is a liquid composition. In some embodiments, the composition comprises a saline solution. In some embodiments, the composition comprises a phosphate-buffered saline (PBS) solution. In some embodiments, the excipient comprises a preservative. In some embodiments, the preservative comprises magnesium or sulfate. In some embodiments, the preservative comprises magnesium sulfate. In some embodiments, the magnesium sulfate is present in the pharmaceutical composition at a concentration of 10 mM.

[0010] In some embodiments, less than 5.0 endotoxin units (EU) / kilogram / hour are present in the composition. In some embodiments, the pharmaceutical composition is substantially free of endotoxin. In some embodiments, the pharmaceutical composition lacks detectable amounts of endotoxin. In some embodiments, the pharmaceutical composition is sterile. In some embodiments, the pharmaceutical composition is substantially free of exotoxins. In some embodiments, the pharmaceutical composition is substantially free of virulence factors. In some embodiments, the pharmaceutical composition is substantially free of antibiotic resistance gene products.

[0011] Also disclosed herein, in various embodiments, is a method of treating an Achromobacter infection in a subject in need thereof, the method comprising a step of administering the pharmaceutical composition provided herein to the subject. In some embodiments, the step of administering comprises systemic administration. In some embodiments, the step of administering comprises parenteral administration. In some embodiments, the step of administering comprises intravenous administration. In some embodiments, the step of administering comprises enteral administration. In some embodiments, the step of administering comprises oral administration. In some embodiments, the step of administering comprises respiratory administration. In some embodiments, the respiratory administration comprises administration by inhalation of an aerosolized form of the pharmaceutical composition. In some embodiments, the step of administering comprises local administration. In some embodiments, the step of administering comprises topical administration. In some embodiments, the step of administering comprises administration to one or more infected sites within the subject.

[0012] In some embodiments, the administration comprises administering more than one dose. In some embodiments, the administration comprises thrice daily, twice daily, daily, twice weekly, weekly, or biweekly dosing. In some embodiments, administration comprises administering multiple doses over a period of at least 7 days.

[0013] In some embodiments, the Achromobacter infection is a chronic Achromobacter infection. In some embodiments, the Achromobacter infection is present in the subject’s lungs. In some embodiments, the subject is afflicted with or at risk of developing a chronic lung disease. In some embodiments, the chronic lung disease is selected from the group consisting of bronchiectasis, cystic fibrosis, emphysema, interstitial lung disease, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and pulmonary hypertension. In some embodiments, the chronic lung disease is cystic fibrosis. In some embodiments, thechronic lung disease is bronchiectasis. In some embodiments, the subject has received a lung transplant. In some embodiments, the subject is immunosuppressed. In some embodiments, prior to administering the composition, the Achromobacter infection is confirmed to be susceptible to at least one of the one or more strains of Achromobacter phage in the composition.

[0014] In some embodiments, the Achromobacter infection comprises one or more species selected from the group consisting of Achromobacter xylosoxidans, Achromobacter denitrificans, Achromobacter ruhlandii, Achromobacter piechaudii, Achromobacter animicus, Achromobacter mucicolens, Achromobacter pulmonis, Achromobacter insolitus, Achromobacter spanius, Achromobacter deleyi, Achromobacter aegreficans, Achromobacter insuavis, Achromobacter anxifer, Achromobacter dolens, and Achromobacter marplatensis. In some embodiments, the Achromobacter infection comprises Achromobacter xylosoxidans. In some embodiments, the Achromobacter infection is resistant to at least one antibiotic class. In some embodiments, the Achromobacter infection is resistant to at least two antibiotic classes. In some embodiments, the Achromobacter infection is resistant to one or more antibiotic classes selected from the group consisting of β-lactams, β-lactamase inhibitors, aminoglycosides, diaminopyrimidine antimicrobials, fluoroquinolones, polymyxins, sulfonamides, tetracyclines, and combinations thereof.

[0015] In some embodiments, the subject is receiving another therapy. In some embodiments, the other therapy comprises antibiotic treatment. In some embodiments, the administration results in improvement in the force expiratory volume in one second (FEV1) relative to a baseline level in the subject. In some embodiments, the administration results in reduced levels of Achromobacter in the subject. In some embodiments, the administration results in non-detectable levels of Achromobacter in the subject. In some embodiments, the levels of Achromobacter are detected from sputum or nasal swab samples from the subject. In some embodiments, the administration results in reduced susceptibility of the Achromobacter in the subject to one or more classes of antibiotics. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] FIGs.1A-1B depict graphs detailing microbiologic responses to Burkholderia- specific phage Bch7 therapy in a patient with cystic fibrosis (CF) and B. multivorans sepsis. FIG.1A depicts Bch7 phage abundance in respiratory samples collected after initiation ofphage therapy, as measured by qPCR. FIG.1B depicts B. multivorans abundance in the same respiratory samples as FIG.1A, as measured by qPCR.

[0017] FIGs.2A-2B depict graphs detailing neutralizing antibody activity following clinical phage administration of two different phages used to treat two different patients. FIG.2A shows phage titers after mixing Bch7 phage with buffer (no serum) versus longitudinal serum samples (pre-phage and day 7 after phage therapy) obtained from a patient with CF who had undergone respiratory administration of B. multivorans phage (Bch7) for 8 days; no serum neutralization was observed. FIG.2B shows the emergence of serum- neutralizing activity against Enterococcus faecium phages 9184 and Hi3. The graph depicts efficiency of plating (EOP; ratio of phage activity in the test condition vs activity in the control condition) values of phages in serum at indicated time points following administration of indicated dosage of Enterococcus phages to a subject with vancomycin-resistant Enterococcus faecium bacteremia.

[0018] FIG.3 depicts a heatmap summary of individual phage activity against 17 Achromobacter spp. clinical isolates obtained from 17 unique persons with CF. White shading indicates no activity, light gray shading indicates weak activity, and dark gray shading indicates strong activity. DETAILED DESCRIPTION OF THE INVENTION

[0019] The present disclosure generally relates to Achromobacter phages, combinations of Achromobacter phages, and pharmaceutical compositions thereof useful in the treatment of subjects afflicted with Achromobacter infection. The present disclosure also provides methods of treating subjects, e.g., subjects afflicted with Achromobacter infection. In certain embodiments, pharmaceutical compositions disclosed herein are effective against infections from a wide range of Achromobacter species. Definitions

[0020] The terms “a” and “an” as used herein mean “one or more” and include the plural unless the context is inappropriate.

[0021] The term “amino acid” refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function in a manner similar to the naturally occurring amino acids. “Naturally occurring amino acids” are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline,.gamma.-carboxyglutamate, and O-phosphoserine. “Amino acid analog” refers to a compound that has the same basic chemical structure as a naturally occurring amino acid, e.g., an a carbon that is bound to a hydrogen, a carboxyl group, an amino group, and an R group, e.g., homoserine, norleucine, methionine sulfoxide, methionine methyl sulfonium. Such analogs have modified R groups (e.g., norleucine) or modified peptide backbones, but retain a basic chemical structure as a naturally occurring amino acid. “Amino acid mimetic” refers to a chemical compound that has a structure that is different from the general chemical structure of an amino acid, but that functions in a manner similar to a naturally occurring amino acid.

[0022] The terms “amplify,” “amplifying,” “amplification reaction,” and their variants refer generally to any action or process whereby at least a portion of a nucleic acid molecule (referred to as a template nucleic acid molecule) is replicated or copied into at least one additional nucleic acid molecule. The template nucleic acid molecule can be single-stranded or double-stranded and the additional nucleic acid molecule can independently be single- stranded or double-stranded. In some embodiments, amplification includes a template- dependent in vitro enzyme-catalyzed reaction for the production of at least one copy of at least some portion of the nucleic acid molecule or the production of at least one copy of a nucleic acid sequence that is complementary to at least some portion of the nucleic acid molecule. In some embodiments, the amplification reaction includes polymerase chain reaction (PCR). The nucleic acid produced by the amplification technology employed is generically referred to as an “amplicon” or “amplification product.”

[0023] As used herein, the term “effective amount” or “effective dose” refers to the amount of a recombinant nucleic acid, protein, polypeptide, or a vaccine or a pharmaceutical composition / formulation of the present invention sufficient to effect beneficial or desired results. An effective amount can be administered in one or more administrations, applications, or dosages and is not intended to be limited to a particular formulation or administration route. As used herein, the term “treating” includes any effect, e.g., lessening, reducing, modulating, ameliorating, or eliminating, that results in the improvement of the condition, disease, disorder, and the like, or ameliorating a symptom thereof. In some embodiments, an “effective amount” of a Achromobacter phage, combination of Achromobacter phage, or a pharmaceutical composition / formulation described herein, is effective to improve lung function (e.g., as described further herein) and / or reduce the level of Achromobacter infection in the subject.

[0024] The term “nucleic acid” refers to a deoxyribonucleotide, ribonucleotide, or mixed polymer in single- or double-stranded form, and, unless otherwise limited, encompasses known analogues of natural nucleotides that hybridize to nucleic acids in a manner similar to naturally occurring nucleotides. Unless otherwise indicated or by context, disclosure of a particular nucleic acid sequence includes disclosure of the complementary sequence thereof.

[0025] The terms “protein,” “polypeptide,” and “peptide” are used interchangeably and refer to a polymer in which a substantial fraction or all of the monomers are amino acids and are joined together through amide bonds, alternatively referred to as a polypeptide. When the amino acids are α-amino acids, either the L-optical isomer or the D-optical isomer can be used. Additionally, unnatural amino acids, e.g., β-alanine, phenylglycine, and homoarginine, are also included. Amino acids that are not gene-encoded may also be used in the presently disclosed compositions and methods. Furthermore, amino acids that have been modified to include appropriate structure or reactive groups may also be used. The amino acids can be D- or L-isomer, or mixtures thereof. L-isomers are generally preferred. Other peptidomimetics can also be used. For a general review, see, Spatola, in Weinstein, et al. (eds.1983) Chemistry and Biochemistry of Amino Acids, Peptides and Proteins Marcel Dekker, New York, p.267.

[0026] As used herein, the terms “subject” and “patient” refer to an organism to be treated by the methods and compositions described herein. Such organisms preferably include, but are not limited to, mammals (e.g., humans, rodents, simians, equines, bovines, porcines, canines, felines, and the like). In some embodiments, the subject is a human.

[0027] The terms “treat,” “treating,” or “treatment,” and other grammatical equivalents as used in this disclosure, include alleviating, abating, ameliorating, or preventing a disease, condition or symptoms, preventing additional symptoms, ameliorating or preventing the underlying metabolic causes of symptoms, inhibiting the disease or condition, e.g., arresting the development of the disease or condition, relieving the disease or condition, causing regression of the disease or condition, relieving a condition caused by the disease or condition, or stopping the symptoms of the disease or condition, and are intended to include prophylaxis. The terms further include achieving a therapeutic benefit and / or a prophylactic benefit. By “therapeutic benefit” is meant eradication or amelioration (1) of the underlying disorder being treated or (2) of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the subject, notwithstanding that the subject may still be afflicted with the underlying disorder.

[0028] The therapeutic response can be any response that a user (e.g., a clinician) will recognize as an effective response to the therapy. The therapeutic response will generally be a reduction, inhibition, delay, or prevention in growth of or reproduction of one or more bacterium, or the killing of one or more bacterium. A therapeutic response may also be reflected in an improvement in pulmonary function, for example forced expiratory volume in one second (FEV1). It is further within the skill of one of ordinary skill in the art to determine appropriate treatment duration, appropriate doses, and any potential combination treatments, based upon an evaluation of therapeutic response.

[0029] Throughout the description, where compositions are described as having, including, or comprising specific components, or where processes and methods are described as having, including, or comprising specific steps, it is contemplated that, additionally, there are compositions of the present invention that consist essentially of, or consist of, the recited components, and that there are processes and methods according to the present invention that consist essentially of, or consist of, the recited processing steps.

[0030] As a general matter, compositions specifying a percentage are by weight unless otherwise specified. Further, if a variable is not accompanied by a definition, then the previous definition of the variable controls.

[0031] In the application, where an element or component is said to be included in and / or selected from a list of recited elements or components, it should be understood that the element or component can be any one of the recited elements or components, or the element or component can be selected from a group consisting of two or more of the recited elements or components.

[0032] Further, it should be understood that elements and / or features of a composition or a method described herein can be combined in a variety of ways without departing from the spirit and scope of the present disclosure, whether explicit or implicit herein. For example, where reference is made to a particular recombinant nucleic acid, protein, or polypeptide, that recombinant nucleic acid, protein, or polypeptide can be used in various embodiments of compositions of the present disclosure and / or in methods of the present disclosure, unless otherwise understood from the context. It will be appreciated that all features described and depicted herein can be applicable to all aspects of the invention(s) described and depicted herein.

[0033] The use of the term “include,” “includes,” “including,” “have,” “has,” “having,” “contain,” “contains,” or “containing,” including grammatical equivalents thereof, should beunderstood generally as open-ended and non-limiting, for example, not excluding additional unrecited elements or steps, unless otherwise specifically stated or understood from the context.

[0034] Where the use of the term “about” is before a quantitative value, the present disclosure also includes the specific quantitative value itself, unless specifically stated otherwise. As used herein, the term “about” generally refers to a ±10% variation from the nominal value unless otherwise indicated or inferred.

[0035] It should be understood that, unless otherwise specified, the order of steps or order for performing certain actions is immaterial so long as the present disclosure remain operable. Moreover, two or more steps or actions may be conducted simultaneously, unless otherwise specified.

[0036] The use of any and all examples, or exemplary language herein, for example, “such as” or “including,” is intended merely to illustrate better the present disclosure and does not impose a limitation on the scope of the invention. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the present disclosure. Bacteriophages

[0037] Bacteriophages (or phages) are simple, yet incredibly diverse, non-living biological entities consisting of DNA or RNA enclosed within a protein capsid. A bacteriophage is a virus that infects bacteria. As naturally occurring bacterial parasites, phages are incapable of reproducing independently (i.e., non-living) and are ultimately dependent on a bacterial host for survival. Phages typically bind to specific receptors on the bacterial cell surface, inject their genetic material into the host cell, and then either integrate this material into the bacterial genome (so-called “temperate” phages) and reproduce vertically from mother to daughter cell, or hijack the bacterial replication machinery to produce the next generation of phage progeny and lyse the cell (so-called “lytic” phages). Upon reaching a critical mass of phage progeny, which can be anywhere from a few to over 1000 viral particles, depending on environmental factors, the lytic proteins become active and hydrolyze the peptidoglycan cell wall, releasing novel phage to reinitiate the lytic cycle (see Delbrück M, (1940) The growth of bacteriophage and lysis of the host, J Gen Physiol.20; 23(5):643-60).

[0038] Most phages are infectious only to the bacteria that carry their complementary receptor, which effectively determines lytic phage host range (see Rakhuba D.V., et al.,(2010) Bacteriophage receptors, mechanisms of phage adsorption and penetration into host cell, Pol J Microbiol., 59(3):145-55). Host specificity varies among phages, some of which are strain-specific. Bacteriophage Strains

[0039] Disclosed herein, in various embodiments, are bacteriophage strains that have lytic activity against Achromobacter bacteria (i.e., “Achromobacter phages”). In some embodiments, the bacteriophage strain is selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07, as described herein.

[0040] In some embodiments, a bacteriophage strain disclosed herein can be identified by sequencing the genome of the bacteriophage. In some embodiments, a bacteriophage strain of the present disclosure can be identified by detecting a nucleic acid sequence characteristic of or unique to the genome of the specific phage (“a characteristic sequence”). In some embodiments, the characteristic sequence is detected by amplifying the unique nucleic acid sequence using a method such as PCR, e.g., using a forward primer and a reverse primer to form an amplicon. In some embodiments, the amplicon comprises about 50 base pairs (bp) to about 200 bp. In some embodiments, the amplicon comprises about 100 bp to about 150 bp, about 100 bp to about 140 bp, about 100 bp to about 130 bp, about 100 bp to about 120 bp, about 100 bp to about 110 bp, about 110 bp to about 150 bp, about 110 bp to about 140 bp, about 110 bp to about 130 bp, about 110 bp to about 120 bp, about 120 bp to about 150 bp, about 120 bp to about 140 bp, about 120 bp to about 130 bp, about 130 bp to about 150 bp, about 130 bp to about 140 bp, or about 140 bp to about 150 bp. Table 1 provides sequences of exemplary amplicons and primer sequences that can be used to identify a bacteriophage of the present invention. Table 1: Example characteristic Sequences of Achromobacter Phages Phage Amplicon Sequence Forward PCR Reverse PCR Primer Primer phiACH01GACAACAGTTTGCCCACGTCGGACAACAGTTTGCC ATTAAAGGAACCAC TCATATACCATCGACAGCCAT CACGTC (SEQ ID CGGCGT (SEQ ID TCCAGGCCGTAGAGGATATCG NO: 6) NO: 7) CGCCGTGCAGCTTCCATGGCT TCTTCAATATCCTTGACGCCGGTGGTTCCTTTAAT (SEQ ID NO: 1) phiACH04GTTTAAGCGCCGAGCAGATGAGTTTAAGCGCCGAG TTCGGTCTTGGTGT CTTCGG AGTTAATATCTAGTTACACCA CAGATG (SEQ ID (SEQ ID NO: 9) TCTTTGAATCACCACCCAGTC NO: 8) ACTTTTCTAAGGACACGATCA TGACCGAAGCCAGCAAGCCCG AAGACACCAAGACCGAA (SEQ ID NO: 2) phiACH05CTGCGTCACAATGATCTGCGACTGCGTCACAATGA TCATCACGCAGATG CGAGCCGGTCATGATCAGCTT TCTGCG (SEQ ID GGCTTT (SEQ ID TCGACGGCTGGTGTAGCCGAT NO: 10) NO: 11) GTCCTTCAGGTCTTCCAGCAG GCCGTGGTGGCGAAAGCCCAT CTGCGTGATGA (SEQ ID NO: 3) phiACH06CGTAGGCTTCATGCTTTCGCCCGTAGGCTTCATGC TTTCGTCGCGGTTC CGATGATCCGTTCGTATTCAT TTTCGC (SEQ ID TCTTCG (SEQ ID CGACCTGGACGACGTTAACAA NO: 12) NO: 13) GCGCGATAGCGACGGCGCACT CGTCTACGCCGAAGAGAACCG CGACGAAA (SEQ ID NO: 4) phiACH07GCGTGGTTATCTACTCCCCGAGCGTGGTTATCTAC GATCGTCAGCACGG TTACCGTCATGAACAATGCCT TCCCCG (SEQ ID TAGAGG (SEQ ID CTGACAAGGTTCAAGTCTCGT NO: 14) NO: 15) CGCAGCAGCAACAGGATGAGG ATGGCAATACCTCTACCGTGC TGACGATC (SEQ ID NO: 5)

[0041] In some embodiments, the Achromobacter phage is phiACH01 or a phage having a genomic sequence at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least99.5%, or at least 99.9% identical to SEQ ID NO: 16. In some embodiments, the Achromobacter phage comprises a genomic sequence comprising the nucleic acid sequence set forth in SEQ ID NO: 1, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 1 or a complementary sequence thereof. In some embodiments, the Achromobacter phage has a genome comprising a nucleic acid sequence that can be amplified by PCR using a forward primer comprising the nucleic acid sequence set forth in SEQ ID NO: 6 and a reverse primer comprising the nucleic acid sequence of SEQ ID NO: 7 to form an amplicon. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 1, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 1 or a complementary sequence thereof. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 1 or a complementary sequence thereof.

[0042] In some embodiments, the Achromobacter phage is phiACH04 or a phage having a genomic sequence at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 17. In some embodiments, the Achromobacter phage comprises a genomic sequence comprising the nucleic acid sequence set forth in SEQ ID NO: 2, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 2 or a complementary sequence thereof. In some embodiments, the Achromobacter phage has a genome comprising a nucleic acid sequence that can be amplified by PCR using a forward primer comprising the nucleic acid sequence set forth in SEQ ID NO: 8 and a reverse primer comprising the nucleic acid sequence of SEQ ID NO: 9 to form an amplicon. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 2, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 2 or a complementary sequencethereof. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 2 or a complementary sequence thereof.

[0043] In some embodiments, the Achromobacter phage is phiACH05 or a phage having a genomic sequence at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 18. In some embodiments, the Achromobacter phage comprises a genomic sequence comprising the nucleic acid sequence set forth in SEQ ID NO: 3, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 3 or a complementary sequence thereof. In some embodiments, the Achromobacter phage has a genome comprising a nucleic acid sequence that can be amplified by PCR using a forward primer comprising the nucleic acid sequence set forth in SEQ ID NO: 10 and a reverse primer comprising the nucleic acid sequence of SEQ ID NO: 11 to form an amplicon. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 3, a complementary sequence thereof, or a nucleic acid sequence at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 3 or a complementary sequence thereof. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 3 or a complementary sequence thereof.

[0044] In some embodiments, the Achromobacter phage is phiACH06 or a phage having a genomic sequence at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 19. In some embodiments, the Achromobacter phage comprises a genomic sequence comprising the nucleic acid sequence set forth in SEQ ID NO: 4, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 4 or a complementary sequence thereof. In some embodiments, the Achromobacter phage has a genome comprising a nucleic acid sequence that can be amplified by PCR using a forward primer comprising the nucleic acid sequence set forth in SEQ ID NO: 12 and a reverse primer comprising the nucleic acid sequence ofSEQ ID NO: 13 to form an amplicon. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 4, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 4 or a complementary sequence thereof. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 4 or a complementary sequence thereof.

[0045] In some embodiments, the Achromobacter phage is phiACH07 or a phage having a genomic sequence at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 20. In some embodiments, the Achromobacter phage comprises a genomic sequence comprising the nucleic acid sequence set forth in SEQ ID NO: 5, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 5 or a complementary sequence thereof. In some embodiments, the Achromobacter phage has a genome comprising a nucleic acid sequence that can be amplified by PCR using a forward primer comprising the nucleic acid sequence set forth in SEQ ID NO: 14 and a reverse primer comprising the nucleic acid sequence of SEQ ID NO: 15 to form an amplicon. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 5, a complementary sequence thereof, or a nucleic acid sequence at least at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, at least 99.5%, or at least 99.9% identical to SEQ ID NO: 5 or a complementary sequence thereof. In some embodiments, the amplicon comprises the nucleic acid sequence set forth in SEQ ID NO: 5 or a complementary sequence thereof. Pharmaceutical Compositions

[0046] Disclosed herein are compositions comprising one or more strains of Achromobacter phage as described herein and a pharmaceutically acceptable carrier.

[0047] In some embodiments, a provided pharmaceutical composition comprises one or more strains of Achromobacter bacteriophage selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. In some embodiments, thebacteriophage cocktail comprises two or more, three or more, or four or more strains of Achromobacter bacteriophage selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. In some embodiments, the bacteriophage cocktail comprises the Achromobacter bacteriophages phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07.

[0048] In certain embodiments, the pharmaceutical composition is capable of killing more than one strain of Achromobacter and / or reduces the ability of Achromobacter strains (e.g., Achromobacter strains present in a subject) to develop resistance to infection by Achromobacter phage . In certain embodiments, the strains in a given pharmaceutical composition can be modified as desired to minimize risk of resistance developing. Pharmaceutically acceptable carriers and formulations

[0049] The pharmaceutical compositions of the present disclosure can be prepared, e.g., by admixing a quantity of phage with a pharmaceutically acceptable carrier. The term “pharmaceutically acceptable” as used herein refers to those compounds, materials, compositions, and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio. Examples of suitable pharmaceutically acceptable carriers include any of the standard pharmaceutical carriers, such as a phosphate buffered saline solution, water, emulsions (e.g., such as an oil / water or water / oil emulsions), and various types of wetting agents. Pharmaceutically acceptable carriers include buffers, solvents, dispersion media, coatings, isotonic and absorption delaying agents, and the like, that are compatible with pharmaceutical administration. The use of such media and agents for pharmaceutically active substances is known in the art.

[0050] Pharmaceutical compositions provided herein can be presented in a dosage unit form and can be prepared by any suitable method and formulated to be compatible with its intended route of administration. Thus, provided pharmaceutical compositions may be in any of a variety of forms. These include, for example, liquid, semi-solid and solid dosage forms, such as liquid solutions (e.g., injectable and infusible solutions), dispersions or suspensions, tablets, pills, powders, liposomes, and suppositories. The preferred form will depend upon the intended mode of administration and therapeutic application.

[0051] In some embodiments, the pharmaceutical composition is an aqueous composition, Suitable carriers for aqueous compositions include, but are not limited to, buffers and / or saline solutions, e.g., a phosphate-buffered saline (PBS), a tris-buffered saline solution (TBS), or a HEPES-buffered saline (HBS) solution. In some embodiments, the pharmaceutical composition comprises a PBS solution. The solution may comprise, e.g., chlorine-free water.

[0052] In some embodiments, the pharmaceutical composition is a non-aqueous composition. Suitable non-aqueous compositions include, but are not limited to, lyophilized compositions or spray-dried compositions. The pharmaceutical composition may be a suspension or a coating or be in tablet, capsule, or powder form.

[0053] In some embodiments, the pharmaceutical composition is aerosolized for administration, e.g., to the subject’s respiratory tract. More than one delivery vehicle, or carrier, may be used.

[0054] The pharmaceutical composition may be formulated as a concentrated composition or a ready-to-use composition. The pharmaceutical composition may be freeze- dried or spray-dried for storage, if desired. Upon reconstitution, the phage titer can be verified using phage titration protocols and host bacteria available in the art. One of skill in the art would be capable of determining bacteriophage titers using any of a variety of widely known bacteriophage assay techniques (Davis et al., Microbiology, 3rd Ed., Harper & Row, Hagerstown, Md. (1980), pp.874-877, 880-883).

[0055] The pharmaceutical compositions can further comprise one or more excipients. The term “excipient,” as used herein, means any non-therapeutic agent added to the formulation to provide a desired physical or chemical property, e.g., pH, osmolarity, viscosity, clarity, color, isotonicity, odor, sterility, stability, rate of dissolution or release, adsorption, or penetration. Excipients of the pharmaceutical compositions provided herein can include stabilizers and preservatives. For examples of carriers, stabilizers, and adjuvants, see, e.g., Martin, Remington's Pharmaceutical Sciences, 15th Ed., Mack Publ. Co., Easton, PA

[1975] .

[0056] In some embodiments, the excipient is a preservative. A preservative can reduce bacterial action and may, for example, facilitate the production of a multi-use (multiple-dose) formulation. In some embodiments, the preservative comprises magnesium or sulfate. In some embodiments, the preservative comprises magnesium sulfate. In some embodiments,the magnesium sulfate is present in the pharmaceutical composition at a concentration of 1 mM to 20 mM. In some embodiments, the magnesium sulfate is present in the pharmaceutical composition solution at a concentration of 10 mM.

[0057] Pharmaceutical compositions comprising bacteriophages provided herein can be formulated to have low levels or be substantially free of bacterial endotoxins. Endotoxins can be detected using any suitable method known in the art, such as the Pyrogen Test (otherwise known as the Limulus Amebocyte Lysate (LAL) test) or the Bacterial Exotoxins Test. In some embodiments, the pharmaceutical composition comprises less than 5.0 endotoxin units (EU) / kg / hour, less than 4.5 EU / kg / hr, less than 4.0 EU / kg / hr, less than 3.5 EU / kg / hr, less than 3.0 EU / kg / hr, less than 2.5 EU / kg / hr, less than 2.0 EU / kg / hr, less than 1.5 EU / kg / hr, less than 1.0 EU / kg / hr, or less than 0.5 EU / kg / hr. In some embodiments, the pharmaceutical composition has no detectable amount of bacterial endotoxin. In some embodiments, the pharmaceutical composition is substantially free of endotoxin.

[0058] In some embodiments, provided pharmaceutical compositions are sterile. As used herein, “sterile” refers to a composition lacking microbial species aside from Achromobacter phages. Pharmaceutical compositions can also be formulated to lack deleterious components of microbes, such as virulence factors (e.g., virulence factors that aid in host colonization (e.g., adhesins, invasins, and pili), tissue damage (e.g., toxins, proteases, and hemolysins), immune evasion and / or modulation, and / or in forming biofilms which form physical barriers to antibiotics) or antibiotic resistance gene products ( e.g.¸ enzymes that degrades antibiotic molecules). Sterility of pharmaceutical compositions can be determined using any suitable method known in the art, such as the USP<71> compendial method, Bactec FX, or BacT / Alert Dual-T tests. Further details of sterility testing are provided in England MR, et al. J Clin Microbiol.2019;57(2):e01548-18.

[0059] In some embodiments, the pharmaceutical composition has no detectable bacteria, fungi, non-Achromobacter phage viruses, parasites, or other microbes. In some embodiments, the pharmaceutical composition is substantially free of virulence factors. In some embodiments, the pharmaceutical composition is substantially free of antibiotic resistance gene products. Dosage

[0060] Appropriate dosages can be determined for each strain of Achromobacter phage (or combination of strains of Achromobacter phage) and may be adjusted, e.g., for in eachtype(s) of infection in a given subject.. The concentration of Achromobacter phage employed for treatment may be determined, e.g., using phage titration protocols. The concentration of Achromobacter phage in a provided pharmaceutical composition may vary depending upon the carrier and method of administration. In various embodiments, the pharmaceutical composition is a liquid composition in which Achromobacter phage is present in a total concentration ranging from about 102to about 1013(e.g., 103, 104, 105, 106, 107, 108, 109, 1010, 1011, 1012, or 1013) Plaque Forming Units (pfu) / milliliter (mL), e.g., a concentration ranging from about 5×105to about 5×1012pfu / mL or about 5×107to about 5×109pfu / mL. In some embodiments, the pharmaceutical composition is a liquid composition in which Achromobacter phage is present in a total concentration of about 5×105pfu / mL, about 1×106pfu / mL, 5×106pfu / mL, about 1×107pfu / mL, 5×107pfu / mL, about 1×108pfu / mL, about 5×108pfu / mL, about 1×109pfu / mL, about 5×109pfu / mL, 1×1010pfu / mL, about 5×1010pfu / mL, 1×1011pfu / mL, about 5×1011pfu / mL, 1×1012pfu / mL, or about 5×1012pfu / mL.

[0061] In some embodiments, the composition comprises a bacteriophage concentration of about 5×107pfu / mL to about 5×109pfu / mL. In some embodiments, the composition comprises a bacteriophage concentration of about 5×107pfu / mL, about 5×108pfu / mL, or about 5×109pfu / mL. In some embodiments, the composition comprises a bacteriophage concentration of about 5×108pfu / mL. Methods of Treatment Achromobacter Infection

[0062] Provided herein, in various embodiments, are methods of treating an Achromobacter infection in a subject in need thereof, the method comprising administering a provided pharmaceutical composition to the subject. In some embodiments, the Achromobacter infection comprises species of Achromobacter selected from the group consisting of: Achromobacter xylosoxidans, Achromobacter denitrificans, Achromobacter ruhlandii, Achromobacter piechaudii, Achromobacter animicus, Achromobacter mucicolens, Achromobacter pulmonis, Achromobacter insolitus, Achromobacter spanius, Achromobacter deleyi, Achromobacter aegreficans, Achromobacter insuavis, Achromobacter anxifer, Achromobacter dolens, Achromobacter marplatensis, and combinations thereof. In some embodiments, the Achromobacter infection comprises Achromobacter xylosoxidans.

[0063] In some embodiments, the Achromobacter infection is determined to be susceptible to one or more Achromobacter phages provided herein. Susceptibility ofAchromobacter to phages provided herein can be determined using any suitable method. In some embodiments, the susceptibility is determined ex vivo by culturing an Achromobacter sample from a subject and administering one or more Achromobacter phage to the cultured sample. In some embodiments, the Achromobacter sample is obtained from the subject’s sputum or a nasopharyngeal swab. In some embodiments, the determining comprises detecting viral plaques on an agar plate comprising the cultured Achromobacter sample. Subjects

[0064] In some embodiments, the Achromobacter infection is present in one or more sites within the subject selected from the group consisting of: the lungs, the skin and soft tissue, the urinary tract, the intraabdominal organs, the central nervous system, the eye, the ear, the heard, the bone, and combinations thereof. In some embodiments, the Achromobacter infection is present in the subject’s lungs.

[0065] In some embodiments, the subject having an Achromobacter infection is afflicted with or is at risk of developing a chronic lung disease. In some embodiments, the subject has a chronic lung disease, e.g., a chronic lung disease that results in or is characterized by a weakened immune system or an environment that is permissive of the development of an Achromobacter infection. In some embodiments, the chronic lung disease is selected from the group consisting of bronchiectasis, cystic fibrosis, emphysema, interstitial lung disease, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, pulmonary hypertension, and combinations thereof. In some embodiments, the chronic lung disease is cystic fibrosis. In some embodiments, the chronic lung disease is bronchiectasis. In some embodiments, the subject has received a lung transplant. In some embodiments, the subject is immunocompromised (e.g., due to cancer or HIV infection) or immunosuppressed (e.g., due to treatment with immunosuppressant drugs). In some embodiments, the subject is immunosuppressed. Antibiotic Therapy

[0066] In various embodiments, the subject is receiving or has received antibiotic therapy for the Achromobacter infection. In some embodiments, the subject is receiving or has received a β-lactam, β-lactamase inhibitor, aminoglycoside, diaminopyrimidine antimicrobial, fluoroquinolone, polymyxin, sulfonamide, tetracycline, or a combination thereof. In some embodiments, the subject has received colistin therapy. In some embodiments, the subject has received trimethoprim / sulfamethoxazole therapy.

[0067] In some embodiments, the Achromobacter infection is resistant to at least one class of antibiotics. In some embodiments, the Achromobacter infection is resistant to at least two classes of antibiotics. In some embodiments, the Achromobacter infection is resistant to one or more classes of antibiotics selected from the group consisting of: β-lactams, β-lactamase inhibitors, aminoglycosides, diaminopyrimidine antimicrobials, fluoroquinolones, polymyxins, sulfonamides, tetracyclines, and combinations thereof. In some embodiments, the Achromobacter infection is resistant to colistin therapy. In some embodiments, the Achromobacter infection is resistant to trimethoprim / sulfamethoxazole therapy. In some embodiments, administration of a pharmaceutical composition provided herein reduces resistance of the Achromobacter infection to one or more classes of antibiotic. Administration

[0068] In certain embodiments, the pharmaceutical composition is administered by a systemic route. For example, in some embodiments, the pharmaceutical composition is administered parenterally, e.g., intravenously, intraarterially, intraperitoneally, subcutaneously, or intradermally. In some embodiments, the pharmaceutical composition is administered enterically, e.g., trans-gastrointestinally or orally (per os). In some embodiments, the administration is intravenous (iv) administration. In some embodiments, the pharmaceutical composition is administered by a respiratory route, e.g., by inhalation of an aerosolized form of the pharmaceutical composition.

[0069] In some embodiments, the pharmaceutical composition is administered by local administration to one or more sites of the Achromobacter infection. For example, in some embodiments, the pharmaceutical composition is administered topically. In some embodiments, the pharmaceutical composition is administered topically to the sternal wound and / or one or more skin nodules. In certain embodiments, the pharmaceutical administration is administered via a medical dressing, e.g., a gauze pad. Dosing Regimens

[0070] In some embodiments, pharmaceutical composition is administered as a single dose, e.g., a single dose comprising an effective dose. In some embodiments, the pharmaceutical composition is administered in multiple doses, e.g., multiple doses spaced out over a period, such as a period described herein. In some embodiments in which multiple doses are administered, the same amount of Achromobacter phage (e.g., total amount of all strains of Achromobacter phage in the pharmaceutical composition) is administered witheach dose. In some embodiments in which multiple doses are administered, the multiple doses collectively comprise an effective dose.

[0071] In some embodiments, the pharmaceutical composition is administered at least once daily (e.g., once a day, twice a day, three times a day). In some embodiments, the pharmaceutical composition is administered once daily, twice daily, thrice daily, once weekly, twice weekly, or bi-weekly.

[0072] In some embodiments, the pharmaceutical composition is administered in a dosing regimen comprising a period of at least one week, at least two weeks, at least three weeks, at least four weeks, at least five weeks, at least six weeks, at least seven weeks, at least eight weeks, at least nine weeks, at least ten weeks, at least 11 weeks, or at least 12 weeks.

[0073] In some embodiments, the composition is administered in successively higher doses over the course of the dosing regimen. In some embodiments, the subject is administered a first dose level in the first week of a dosing regimen, a second does in the second week of a dosing regimen, and a third dose in the third week of a dosing regimen. In some embodiments, a dosing regimen comprises multiple routes of administration. In some embodiments, a dosing regimen comprises a first period of administration of the composition via a first route and a second period comprising administration of the composition via a second route. EXAMPLES Example 1: Treatment of Bacterial Infection in a subject with Chronic Lung Disease

[0074] A patient having cystic fibrosis (CF) and Burkholderia multivorans (B. multivorans) sepsis was administered a Burkholderia-specific phage (Bch7) over the course of 8 days at 1×1010plaque-forming units (PFU) / day. Abundance of phage and B. multivorans abundance were measured with qPCR. Phage DNA was detected in respiratory samples on day 6 post-phage (FIG.1A). Additionally, it was observed that B. multivorans abundance decreased following phage administration (FIG.1B). These results indicate that a lag may exist between initiation of inhaled phage and phage replication, but that inhaled phages are able to successfully target and reduce the burden of the pathogen that they are active against.

[0075] To assess the presence of a neutralizing antibody response to phage in the same patient who received inhaled Burkholderia phage, serum was collected before and 7 days after phage administration. There was no evidence of neutralization of administered phagesafter 1 week (FIG.2A). Serum was also collected over the course of several months from a separate patient who was treated with an Enterococcus-specific phage for vancomycin- resistant Enterococcus faecium bacteremia . Evidence of phage neutralization was observed following a dose increase (FIG.2B). These findings suggest that a neutralizing antibody response to phage can develop in some patients. Example 2: Isolation and Screening of Achromobacter Bacteriophages

[0076] A panel of five Achromobacter spp. clinical isolates was used to identify phages present in hospital and municipal wastewater samples collected from the Pittsburgh area. Wastewater samples were centrifuged at 4,000 rpm for 20 min to pellet solid debris, then supernatants were filtered through a 0.22 ^m filter and concentrated by centrifugation using an Amicon 100 kDa filter unit (Millipore Sigma, Burlington, MA) at 4,000 rpm for 15 min. Lytic bacteriophages present in the filtered and concentrated wastewater were identified with a soft agar overlay assay. Briefly, bottom agar plates were prepared containing tryptic soy broth (TSB) with 1.5% agar, 1 mM CaCl2and 1 mM MgCl2. Bacterial isolates were inoculated into TSB and were grown overnight at 37 °C. Then 100 ^L of stationary phase culture (OD > 1.0) was added to a tube containing 100 ^L of filtered concentrated wastewater for 5–10 min at room temperature, and 10 mL of top agarose (TSB with 0.5% agarose, 1 mM CaCl2, and 1 mM MgCl2) cooled to 55° C was added and the mixture was plated onto two bottom agar plates. Plates were incubated overnight at 37 °C and were examined the following day to identify lytic phage plaques. Phages were passaged by sequential picking and plating of individual plaques grown on the same bacterial isolate. Phages were picked from individual plaques using a pipette tip and were placed into 100 ^L of SM buffer (50 mM Tris-HCl pH 7.5, 100 mM NaCl, 8 mM MgSO4) and incubated overnight at 37 °C. The following day, serial 10-fold dilutions were made in SM buffer, and 3 ^L of each dilution was spotted onto a plate containing 5 mL of top agarose mixed with 50 ^L of stationary phase bacterial culture (OD > 1.0) and layered on top of a bottom agar plate. After overnight incubation at 37 °C, an individual plaque was picked and passaged again. Each phage was passaged at least three times before the generation of high-titer stocks. To generate high-titer stocks, a single plaque was picked into 100 ^L of SM buffer and incubated overnight. Then, 100 ^L of overnight bacterial culture (OD > 1.0) was added, and the mixture was incubated for 5– 10 min at room temperature, followed by addition of 10 mL of top agarose and plating onto two bottom agar plates. Plates were incubated overnight at 37 °C, and then plates withhigh plaque density were flooded with 5 mL of SM buffer and incubated at 37 °C for at least 1 h to elute phages from the top agar. SM buffer was removed from each plate, pooled, spun down at 4,000 rpm for 20 min, and filtered through a 0.22 ^m filter. Phage-containing lysates were extracted with 0.1 volumes of chloroform followed by 0.4 volumes of 1-octanol, and were stored at 4° C.

[0077] Phage susceptibility testing was performed for each of the five phages in the cocktail against 17 Achromobacter spp. clinical isolates collected from persons with CF. Briefly, 100 ^L of stationary phase culture (OD > 1.0) of each isolate was added to a tube containing 10 mL of top agarose, and the mixture was layered on top of a bottom agar plate. Serial 10-fold dilutions of each phage were prepared in SM buffer, and 5 ^L of each dilution was spotted on top of the solidified top agarose containing the clinical bacterial isolate. Plates were incubated overnight at 37 °C and were assessed the next for phage activity. The titer of each active phage was recorded in plaque-forming units (PFU) per mL. Among the 17 isolates tested, 13 were found to be susceptible to at least one phage in the cocktail (FIG.3). These results indicated a cocktail containing five Achromobacter-targeting phages that together have lytic activity (i.e., infect, replicate, and cause cell lysis) against over 75% of the panel of 17 genetically diverse Achromobacter clinical isolates collected from 17 unique persons with CF. The five phages in the cocktail are named: phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07. Example 3: Treatment of Achromobacter Infection with a 5-Phage Cocktail

[0078] This example details an open-label, randomized Phase I trial of ten adults with Achromobacter lung infection who receive a cocktail of five Achromobacter phages, either intravenously or via inhalation. The primary objective of the study is to determine the safety and tolerability of Achromobacter phages in individuals with cystic fibrosis (CF) or other chronic lung disease. Participants are enrolled who are infected with Achromobacter that is determined to be susceptible to at least one phage in the cocktail. The five-phage cocktail is administered to ten individuals with Achromobacter infection, who are then followed for safety and tolerability of the cocktail. Exploratory endpoints include changes in FEV1 vs baseline ii) Blood PK of each phage using qPCR iii) Achromobacter abundance in sputum or nasal / oral swabs using qPCR and selective plating and quantification iv) Antibiotic and phage susceptibility of Achromobacter v) Impact of phages on total bacterial abundance using qPCR, and vi) Number of subjects with a phage-neutralizing serum response.Study population and enrollment

[0079] Screening occurs approximately one week prior to enrollment. Participants with all stages of lung disease severity are considered. Three patients whose isolates are confirmed by to be susceptible to at least one phage in the cocktail will undergo initial screening for eligibility. For additional potentially eligible subjects, phage susceptibility testing is performed against their isolates during screening, and subjects are enrolled if susceptibility is confirmed. The sample size of the trial is ten participants, which is based on feasibility of enrollment during the study period. Inclusion Criteria

[0080] The inclusion criteria for subjects in the trial are: ^ Adult (at least 18 years old) ^ CF or other chronic lung condition (e.g., bronchiectasis, lung transplant, other) regardless of stage of lung disease ^ Chronic Achromobacter respiratory tract infection ^ Susceptibility of a cultured Achromobacter isolate to at least one phage in the cocktail: is confirmed during screening, prior to enrollment Exclusion Criteria

[0081] The exclusion criteria for subjects in the trial are: ^ Acute illness ^ Life expectancy less than one year as determined by the principal investigator ^ Pregnancy or intent to becoming pregnant within six months ^ Breastfeeding ^ History of intolerance to inhaled therapies ^ History of any other current condition that, in the opinion of the principal investigator, would interfere with the conduct of the study or would not be in the best interest of the participant to enrollCocktail Administration Phage Cocktail:

[0082] The five-phage cocktail contains an equal mixture of each phage. Each phage is manufactured separately and is rigorously tested to ensure that each preparation meets standards of USP71 sterility and endotoxin levels. Dose / route:

[0083] Participants are randomized to one of two groups using permuted block randomization (5 blocks of 2, with an N of 5 participants in each group): Participants randomized into the IV group receive 3 single, escalating doses of IV phages 1 week apart (weeks 1-3). Participants randomized into the inhaled group receive 3 single, escalating doses of inhaled phages 1 week apart (weeks 1-3). The same escalation pattern is used for both IV and respiratory formulations. The dosing schedule is summarized in Table 2. There is no placebo group. Participants are monitored for adverse events (AEs) for 4 hours post-phage administration, undergo collection of blood, sputum, nasal, and oropharyngeal swabs, as well as pulmonary function testing during visits, and are followed for AEs until 4 weeks after the last dose of phage through phone calls, study visits, and symptom diaries. The total study duration is approximately 7 weeks. Table 2: Dosing Schedule of Bacteriophage Randomized to IV route Randomized to inhaled route Week Dose (PFU / mL) Administration Dose (PFU / mL) Administration 1 5×107IV 5×107Respiratory 2 5×108IV 5×108Respiratory 3 5×109IV 5×109Respiratory

[0084] Subjects undergo a 3 mL blood draw before each phage dose, then at 10, 30, 60, 120, 180, and 240 minutes. During each visit,: a) morning sputum expectorated at home is collected during normal respiratory therapy (in specimen cups previously provided to participants), b) sputum collection is attempted during the visit (if feasible), and c) nasopharyngeal (NP) and oropharyngeal (OP) swabs are obtained pre-phage and at 240 min post-administration. Two approaches are included to address the possibility of someparticipants being unable to expectorate due to CF modulators, and to address variability in bacterial burden by body site. First, all subjects are provided with collection cups and attempt to expectorate early in the morning and during respiratory therapy. Second, NP and OP swabs are collected during study visits. All samples undergo culture and qPCR analysis. A full summary of the experimental schedule is provided in Table 3.O W8 #2780X X X X X XiXiXiX X X X X X X0-BPU.oNtekcoDyenrottA 72m 1.752868821 / STPIO W8;2dgn si,setm uu dtna0e ti n u s ,--l m ds i p0BPU.oNtekcoDyenrottA 821.752868821 / STPIPrimary Endpoint

[0085] The primary endpoint of the study is the Development of treatment-related grade 4 or greater or treatment-limiting (regardless of grade) adverse events after administration of the 5- phage cocktail (weeks 1-7), overall and stratified by treatment group. Secondary Endpoints

[0086] Secondary endpoints of the study are: ^ Changes in forced expiratory volume in the first second (FEV1) vs baseline (weeks 1-4, 7) via a spirometry device; ^ Detection of phage in blood (pharmacokinetics, PK) using qPCR (t =0, 10, 30, 60, 120, 180, 240 min post-administration); ^ Changes Achromobacter abundance in sputum / nasal swabs using qPCR and selective plating and quantification (weeks 1-4, 7); ^ Changes in antibiotic and phage susceptibility of Achromobacter (weeks 1-4, 7); ^ Changes in total bacterial abundance using qPCR of a conserved 16S rRNA region (weeks 1-4, 7); ^ Development of a phage-neutralizing response (weeks 1-4, 7). Statistical and Analytical Plan

[0087] Statistical modeling focuses on estimation and precision in outcome assessments. Point estimates and 90% confidence intervals (CIs; 90% given pilot nature) are reported at each week for all outcomes. Binary outcomes (e.g., safety / tolerability) are operationalized as the proportion of participants in whom phages are safe / tolerable and are modeled via random intercept (RI) logistic regression. Continuous outcomes (e.g., changes in phage / bacteria abundance or FEV1; transformations applied as needed) are modeled via RI linear regression. The two delivery methods are modeled separately, and all models include week as a categorical predictor. Odds ratios and back-transformed estimates of incidence are reported for primary outcomes along with 1-sided 90% CIs. Estimated mean differences on the transformed and back-transformed (original) scales are reported along with two-sided 90% CIs for secondary outcomes. Assuming phages are safe and tolerable in ≥90% of patients, one-sided exact 90% CIs for these binary measures have CI widths of at most 34% (90% CI: 66%-100%). For continuous endpoints, two-sided 90% CI widths of at most 1.16 standard deviations are observed, assuming a moderate within-patient correlation of ρ=0.5 (personal estimate). The proposed likelihood- based statistical procedures (RI models) allow for analysis of every patient’s data, regardless of attrition, and provide valid results when data are “missing at random” (MAR). If the MAR assumption is found to be questionable, shared parameter models that allow for non-ignorable missingness are fit. Safety assessments:

[0088] Baseline symptoms and co-infection with other pathogens is recorded at enrollment. Clinical signs / symptoms and laboratory results are reviewed by study coordinators and the principal investigator. Adverse events (AEs / severe AEs) as defined by the U.S. Department of Health and Human Services are assessed. Solicited AEs are assessed from symptom diaries completed by participants at home, unsolicited AEs, unexpected AEs, and suspected adverse reactions. Subjects are followed for AEs for four weeks after the last phage dose. AE severity is graded according to the National Cancer Institute’s Common Terminology Criteria for AEs Version 5.054. The attribution of an AE to the study procedures is determined by the principal investigator. AEs are reported to the FDA / institutional review board (IRB) per FDA regulations. All SAEs and AEs requiring interruption of study treatment or further evaluation are brought to the immediate attention of the principal investigator. If any study-related Grade 4 AE or SAE occur, or if 2 or more subjects experience related Grade 3 AEs, the study will be temporarily halted pending review. Example 4: Assessment of the pharmacokinetics of phage and the impact of phage therapy on bacterial abundance and Achromobacter susceptibility profiles. Phage quantification:

[0089] Total DNA is extracted from specimens collected from study participants from Example 3. Sputum is pre-treated with Sputasol, a liquifying agent for sputum samples. Sputum and other samples (serum, swabs, urine, stool) are subjected to genomic DNA extraction. qPCR is performed using primers that amplify each of the five phages in the cocktail. Standard curvesare generated, and primer efficiencies are evaluated. If cross-reactivity or inefficient amplification is observed, primers are redesigned before proceeding. qPCR data are converted to phage DNA abundance in each sample using standard curves. Data are compared between phages, sample types, and time points. Reactions are run in triplicate. Bacterial quantification:

[0090] Total bacterial abundance and Achromobacter abundance specifically are quantified in each biospecimen collected from study participants by qPCR using the same approach as above. Primers amplifying a conserved region of the 16S rRNA locus as well as an Achromobacter- specific target are used. Selective plating is also performed for quantification of bacteria able to grow on MacConkey agar in each sample. From the bacteria that grow, Achromobacter clones are isolated and identified for susceptibility testing. Susceptibility testing:

[0091] Antibiotic and phage susceptibility testing is performed on Achromobacter isolates. Levofloxacin, trimethoprim-sulfamethoxazole, minocycline, imipenem, ceftazidime-avibactam, piperacillin / tazobactam, and cefiderocol are tested. Phage susceptibility testing is performed by determining the titer of each phage against each isolate. Briefly, 10-fold serial dilutions of each phage are spotted onto top agar overlays containing each bacterial isolate; plates are incubated overnight at 37 °C. Individual plaques are counted to determine the PFU / mL for each isolate. Two biological replicates, each with two technical replicates, are included per isolate. Example 5: Assessment of Humoral Responses to Achromobacter Phage Therapy

[0092] Serum is analyzed for phage-neutralizing activity. Briefly, serum is diluted 1:10 into a high-titer lysate of each phage used in the cocktail. A control containing only buffer is also tested. Serum or buffer and phage is incubated together for 24 hours at 37° C. Serial 10-fold dilutions of this mixture are spotted onto a top agar lawn containing a phage-susceptible Achromobacter isolate. Plates are incubated overnight at 37° C; plaques are counted the next day to determine PFU / mL. Two biological replicates, each with two technical replicates, are run per sample. If neutralization is observed, this activity is characterized using ELISA (for IgA, IgG, IgM).SEQUENCE LISTING

[0093] SEQ ID NOs: 1-15 are as shown in Table 1.

[0094] SEQ ID NO: 16 (exemplary genomic sequence for phiACH01) GCCTATGTGCAGCGGGCTGTCTTCGTGAACTTCACGGAGCGCACTCTTCTGGGGCTTCAAGGCCAGGTATTCGCTCA AAATCCTGACCTCAAGCTGCCAAAAGACCTGGAAGGTCTGCTTTCGGACGCTGACGGCGACGGTGTTGGCCTGATCG AACAACTCGAGCAGTCCGTGGGCTACCTTTTGGCTTACGGTCGAGCTGGTTTGCTGACCGATTACCCGACGCAAGAC GAACCGATCACGAAAGCACAGCGTGATGCGGGTGAAGTCGGCCCTAAGCTGATCCTCTTCAGCCCGTTCTCGATCAT CAACTGGCGGCACACCTTCTACAAGGGGCGCAATCGCCTTTCGCTGGTGGTTCTGTCCGAGCAATACCCGCTTGAGG GTGATGGCTTCGAGCTGAACTATGGCCAGCAATGGCGCGTGCTGCGTCTGGAAGATGCCGATACGCCTGAGCCCAAG TACCGGATCGACATCTATCGCCGTGGTAAGCGCGATAATGACCCGGCAGCGCCTACGGGTGCTGAAAACGTAGGTGC CGGCGAAATCGTCCTGCATGATACAATCGAACCACTCGATTACAATGGTAACCGATTGTCGTACATCCCGTTCGAGT TCATCGGGTCCAACAACAACAATGCCTCGCCGGACAATCCGCCGCTGCATTCGATTGGCTCTGTGAATATCGCCCAC TACCGCAACTCGGCGGACTATGAAGAATCCTGCTTCATCGTCGGCCAGCCAACGGTCTGGGTTTCGGGCGTTGATGA GAACTACGTCAAAGAAGCTTGGGGCGGCAAACTCTACCTCGGCTCTCGTGCCATTGTTACCTTGCCTCCGGAAGGAT CGGCAGGTATTCTCCAGGCTCAGCCTAACTCGCTTCCGATGGAGGCGATGAAGGACAAGCGGGAGCAAATCGTCGCT TTGGGGGCCAAATTGGCCGAACCTGGAAAGGTTCAACGAACTCTCGGTGAGGCTCGTCTCGAAGAGGCAACGCAAGC TTCGGTTCTGGTCAATTGCGTCCGGAACACGCAGTCTGCGTACCTCAAGGGCCTCAGTTATGCCATCCAGTTTCACG GTGGCGACCTTGAGGACCTGAAGCTGGTTATCTCGACGGACTTCGCCATCTCGCGGTTGGAACCCAACGAACGTCAG GTTCTCATCAATGAGTGGATGGCCGGCGCGATCACCACTAACGAGCTCCGTAGTCAGCTCCGTAAGGCAGGCATTGC TTATGAACCTGACGACAGCAAGGAGATTGGTGTTCCGCGTAAAGGAGCGGAAGATCCATCTCAAAACACCACCCAGA CCAAACCCAAGGACGAATGACCATGAAATTCTACCTCAGCAAGGCCGAATACGAAGCCCTCGATGACAGCCAAAAGG CACTTTACAAGGCGGCTGCGGACGGCCGCTACAAACTGTCTCTGGCCGACGATGACCGTGATGAACAGGTGACCCAC CTGACCCAGAAGAAGGGCATCGCCGAAGAGCATCGTTCCAATGCCGAGCGCCGCGTGCAAGAACTGACGGCCAAGGT CGAAGAGCTGACGGCCAAGATAGAGAAGGGCAATGACGACACCCACCGCAAGAACGGCGACGTCGACGCCCTGGACA AGTCCTGGAACACCAAGTTCGACAAGCAGAAGGCCGAGTACGAGGGCACGATCGCCTCGTTGAACCAGTCCCTGACC GAACTGCTCGTCACCGGCGTGGCTCAACGCTTGGCCGCGGAAATCAGCACGGCGCCTGACCTCCTGGCTCCGGTCAT CGCGAAGCGTCTTCGCGTGGAACAGGTCGATGGCAAGCACGTGACCAAGGTGATCGACGACGCTGGCAATCTGTCGG CGTTGACCATCGAAGACCTGCGCAAGGAAATCGCTGGCAAAAAGGAGTACGCTAGCGTTATAATTGCAGGCAAGGGT TCTGGCGGCGGCAGCCGCGGGGGCCAACAGCGCGGCGGTGCCAGCGATAAGAAGTTTTCCGAGCTCTCCGATGAGGA GCGCGTGGAATGGCTCCGCCGCGACCCTGCAGGGTTCAAACGGGCCGCGGCTGAAGCGAAGAGCGACGGCATCAGCA TCTAACAAACCCTTCAGGAGCATTTCAACATGCCAACCACTCGTCTTTCCGACGTTGTCATCCCGGAAGTCTTCGAC TCCTACCAGGCTGTCAACACCGCTGAACTGGACACCTTCTACCAGTCCGGCATCGTGGTCCACTCGGACCTGTTCGA TTCGTACGCCAACCAAGGCGGCTCGAAAGTCACCATTCCGGCCTGGGGCGACCTGGACCTGAATGAAGAGCCCAACT ACGGCAACGACGACCCGAATCAACTGGCCGTTCCGCTGGCCATCGGCACCCTGGAATGGGACGTCCGCAAGGCGTTC ATGAACCAAGGCTGGTCCGCCATGGACCTGGTGCAAGAACTGGCCGGCTCGAATCCGATGCGCCGCATCCGTGCCCG CGTCGACAAGTACTGGCTGGGCCAATGGCAGCGCCGCCTGATCGCTTCGTCCCTGGGCATCATGAACGCCAACATCG CCAACGACGGCGGCGACATGGTGTACAACATCGCCATCGAAGACGGCGACAACGCCACGGACGCCAACCTGTTCTCG CGCAAGGCTCTGTCCGGTGCCATCTTCACGATGGGCGATCGCTGGAAGGACACGCGTGCCATCGCCGTGCACTCCAT GGTCATGAAGCGCATGGTCGACAGCGACGACATCATCACGGTGCGTCCGTCCAGCGGCTCCGACGAGGTGCACTACT TCCTCGATCGCCGTGTGATCGTGGACGACATGCTGCCGGTGATCCCCGGCGAAGACTCGGGCTTCAAGTACGTGTCT ATCCTGTTCGGCGGCGCCATGTTCGGCTACGGCAACGGCACGCCCAACATGCCGACCGAAGTCGAGCGCGAAGCCCG TGCCGGTAACGGCGCCGGCATGGAAACGCTCTGGACGCGCAAGACGTGGATCCTGCATCCGAAGGGCCACAGCTTCA CCAGCGCGTCCATCACGCCGCAGCCCAATGGCGCCGTGCCTCCGTCGGCCACCCTGGCCGACCTGCAAAAGGCCGCC AACTGGGACCGCGTCGTCGAGCGCAAGCTGGTGCCGATGAGCTTCCTCATCACCAACGGTTAATCGGCTGGGTGGCT GATTTACCCCGGGGCTTCGGCTCCGGGGCCTTTTTCTGCAAAGGAGAAAGACATGCCCGACATGATCTGGCCCGGCA CCAACCCGAGCCTCCCGACCCTGCTGGAAGCGCAGGACAACATCGACATCGCCAATGGGATGTTTCCCGGCGGTCCC GTCTTTTCCGGCGGCAATCTGACCTTCGACAAGATTCGCGGCGTTGCCACGCCCGCGCAACTGCCGAAGGCCACGGC CACCGTTGAAGGCATCGTCAAGCCTGGCACTGGTCTGGAAGTCGTGACTCCCGGAACCATCAGCGCCGCGGCTTAAG GAGCCGACATGCGAGGAAAACTCAAGCCCTTCGACCTTTCCAAGGGCAATCCCAAGTTCAGCGACCTGCTGAAGCAC TCGATCGCAACCGACAAGCGGCTGGCTCAAGAAGCTGAAGGTGGTGGAACCACCGACGACTTCGGCGAGACCTTCGA CGTCGGTGCCATCGAGACCGAACGCGACAACGCTTTGGCGCGAGTCAAAGAGCTGGAGCAGGAGGTCGCGGACATCA AGGAACGTGCCACCAAGCGCGTTGGCGAACTGAAAGCTGAGCTGGAAGCAGCCCAGTCTGAAATCAAGACGCTGAAA GCGCCGGTGGCCGCCAAGAAGTCGACCAAGGCGGCGGATACGCCCAAGGAGTAAAGCATGGCTATCACGTTGGTCCTGGAAGACGGTACTTCGAAGTCCAACTCCAATACGTACGTCACGGAAGAAGACTTCCTGGCGTATGCAGAAGGGATGG GGTTCGAAATCGCCACTCCAGCCGACGTGGTGCCTGCTCTGCTCAAAGGTTCTCAATACCTGGACTTGGTTCCTCGT GCTGAGTACCAGGGCTCCAAGACTGTTGCGACGCAGGCCATGCAATGGCCTCGTCGCGGCGTCACTATCGATTGCGT GGCATTCCTCGACAATGCCATTCCCAGGGAATTGAAGGTAGCTCAAATGGAGCTTGCCCTCATCGCCCTGCAAGATG ACTTTCTCGAGCTCTTCAAGAACTCGGATGGTTATCCGGTCTACCGAGTTAAGGTGGACGTGATCGAAGAGCAGTAT ATGACACCCCGTCAGCTGTCAACCCGGCCCGACGGTTCCATACAACAGCCGCAGTACCCCAAAGTCGACGCGCTCCT GTTCCCACTTCTGAAGGGCAACGAATGCCCAGGAGGAGGAAGCTCGGGTTGGGCGCATCTGCGGGTTCTGAGGATGT GATATGGCCATCAGGCTCCACCGGCTCGCTTGGGCCGAACGCACGGCGCTCCGGCTCATCAAAGAGTACGGAGCGCC TTGTCGTATGACGATCGACTTTCCTGGGCAGCCTATTCCTGGCGAACCTGGACGAGTCGGGCCCAGTCTTCAAGAGA CTGTCAATTTCAGCGGGGTGGTTCTCTCCAACCTGACTGATATCCAAATCCCGTCAAACGTCGTCTTCTCTGACGTG CTTATGGCTGCTTCGAGTGAGTTTCGCCCGTCAGTAGCTATGCCTTCCCCTCCGACGGAGTATCTCCTTGGTGCTGC GACGTCCATTTTCAAAGAGGGGCAGTGGAAGCAAATGCGGGTAAAGCACGTTCAGCAAGTTGTCCCCAATGGGAACA GCATTATTTTCCGCTTTTTCTTGGGGGCATAATGCCAATCACATCTACTGCTGAAGCCCGCAACGTCATGAACAACA TGGCACAGTCGGGCATTGTAGCTGGGCAAATTCAGTTTGTCGGCGACCAAAAGCTTACGGTACCAGAAGGCAATATT GACTGGTGCCGTGTGCAGATTACACATGCGCTGGGCAATCAGGAAACACTGGCTGATTTCAATGGTGTTCGTCGATA TAATCGTACGGGTACGATCATTGTACAATGCTTTGCGCCGCTCTCTGACCGCGGTTTTTCTCGAGCAGAAGCTTTAG CGGAGCAAGCGGTCAAGGTCTACGAGGGCAAGGCAGGAGCCGGTGGTATCTGGTTCCGCAATGTTCGATCTGTCGAG GTTGGTGCTGCAGACGGTTGGCACCAGTTCAACGCAATTGCGGAATTTGACTACTCAATCAAGAGGTAACTCATGGC TACCTGCCAAGTACGAAAGATCGACTCCAACATTGTTGGCCTGCGCATCGCTCAAGAGGAGTGCTTGAAGCAACTCC CGCAAGTGGTGGGCGACATTGTGTGGAATCCCTTGGAACCGAACGGTTACCAGGACTTCGGCGTGCAGACCTCCATG GTCGCGCGCAACCCCATCAACCCTTCGCGTCAACGCCAAAAGGGCATCGTCACCGACCTGGAAGCCTCGGTCGGCTT TGGCCTGGATTTTGTCTATGCCGAGCAGAAGCGCCTGTTGCCGGGCATGATGTTCGCTGAGATCCACCAGCCTGTCG CTGCGATGGTGGCAGTCACCGATGCTGAAGTCACGATCGTCGGCGGCATGATGCGCCTTGAAAGCGCGGACTTGGCG ACCGTCGTCTCTGAAATCCGCGCTGGCGACTGGCTGTTCATCGGTGACGCAGCTGGCCGCTTTGTTGCTGACGGCAA CTGCGGCTTCAAGCGTGTGCGCTCGATCGAAGCTGGCGCTCTGGTATTTGACAAGGGTATCGAAAACGCGGAAGCAG AAACCTTCGTTGGTGATCTGTCCGTGTACCTGCCGGCAACGCTGCGTAACGAATCGGGCTCCGACATCGTGCGCACC TCGTATCAATTCGAGCGCACGCTCGGCTCGCTGGACGGCCTCGATCCACCGCAGGCGGAGTATGTGAAAGGCGCCGT GTCGAGCACGTACGCCCTGAACATGCCCACGGCGGACAAGATCACGACCGACTTCACGTACACGGCCTGCGACGGCG AACTGACCACGCAAGCTGATGGCCTGAAGCCGGGCACTCGTCCGACGCTTCCCGACGCCGACGCTTACAACACGTCG ACTGACCTGAAGCGGGCGGTTATGTCCCGCGTCCATACGGGTACGGTGGCTCCCGAGCCTCTGTTCGGTTTCCTGCT GGAATCCACGCTGAACATCAACAACAACCTGACGGGCAACAAGGCTCTCGGTGTCGTCGGCAACTTCGACATCACGG CCGGCACGTTCGAAGTGAGCATCTCGGCCACGGCGTACTTCTCCGATGTGACCGCGATCCGAGCTGTTCATGAGAAC GCGGACGTTACGCTTGACTATCTTCTGATGAAGAACAACCAAGCGGTCATGTTCGATCTGCCGATGTTGGCTCTCGG TGACGGCCGTCCCGCTGTTGAGCTTGACCAGCCGATCACGCTGCCTCTGACGGGCGATGCGGCCACGGCCAAGAAAC TGGGTGAAGACTTCAACTACACCCTCAACGTGAACTTCTTCGACGCTCTGCCTCCTCTGGCGGCTGAGCTCTACGAA GGCGAATAACACCTTTCAACCCACCCAGCTGATTAGGAGCTTTACATGAAAACCAACCCTTACGCCCAGTTTGCTTC CGACACCAACGCGGAGAAGGAAGGCATCTGGATCAACTATGACCTGTTCCGTGTGCTTCTGGCGCGCGCTGGTGGCT CGAACGCCGCGTACCTGAAGGCAGCGGACCGCAAGCACCGCGCCATGCGTCGTCAAGGTTCGCAGGGTGTCATCGCT CTGCAGCGTCTGGCCCGTGAGCTGCTGGTCGAAGCGTGCATCAAGGACTGGCAAGTTCGCGCCGAAGACGGCACGTT CCTGCCGAACACGATCCAACTGCCTGACGGCTCCATCGTTCCCTTCAACAAGGAAAACCTGGAAGCCGTCATTCACG CTATGCCGAACCTGGCAGACGCCCTGAACGCCGAGGCCAACAACGAACAGTTGTACCTGGCCGAAGAACTGCAGGAA GAAGCGGGAAACTGATCGAAGTCCTGGTCTACGGCGTAGAACAGGATGAAGAGCAGATTGAGTTCATACGGCAGCAA TGCTTGCAACAAGGGCGACCTCTTCCAGCCCGAATTGCAAATGCCCCTGAACTCAAACCCGGCCTAGAACTTTACTG GTACGCCTTTCAGCGTCTCAGCAGTGGTAGACCGGTCGGCTTAGGCCCTGGAGCAATCTCCTGGATTCAAATCGAGG AGTATTGCGACAGGGTCGGGTTGTACGGGGAAGAGCGGGATATCATGCACCACCATATCCAGAAAATGGATAAAGAA TACTTGAAGGCCGTTAAAGCAAAGGCCGCCAAGAATCGAGGTAAAAGCAATGACCCGCCCGTCAACAAGCGTTAGCT TTACCAACTTCAGTAAACGGATGCGCTCGCTAGGGCAGTCTGTGGAACACAACTCGCGAGAGGGTGTGAAACGGATT GCCCGAGCCACCGTGATAGAACTCATCAATCGGACACCTGTTGATACAGGACAGGCAGCGTCCAATTGGCAAGTGGG ATTAGGATCCTTTCCAGCTGGTCCTAAGTTCGGGTTCACGGATATTCCCGCCGCTCGTGCACTCGCCCTGGCCATGA TTGAACAAAGACAGGCAGGCCAAAATGTCTACATCTCCAACCTCCTCCCGTACATTGGCCGGCTGAACGCCGGATAC TCTGCTCAGGCGCCGGTTGGATTTGTGGAGAACGCTCTTGTCCAAGCTAGGGCAATTGCGCGAAACATAAGGCTCCT TGAAGATGGCCGAAGAACTTCACGTTGAGGTTACCGAGCGCGGAGCGCGCGAGGTAAGCCGAAATATCTCTGATATC GGCGTTGCGGCGACCGGTGCTCTCAATCCTCTGCGAAACCTTGAGCGCTTGCTCGCAGGCTTCGTTTCGCTCCAAGC TCTGCAATCACTGAGCAAGACCCTCGACACTTACACCGAGATGCAAAACCGTCTCAAGACCCTGGTAGGAGCCACCG GCGACTACAACGGGGCCTTGCAGCGCTTGGCAAACATCTCGGCAAACACCCGTTCCTCGTTGAAAGACAACGTGCTC CTGTTCCAACGAATGGGTTTGGCACAAAACGAGTTGAACGCGTCGACTAATGAGCTGTACAAGGTGTCCGAAACTGT CGCACAAGCCATTGCCATTCAAGGCGGCTCGGCGGCTACGACGTCGGGCGCAGTTCTTCAATTGTCCCAGGCATTTGGCTCCGGACGCGTACAACTGGAAGAATTCAACTCGGTTATCACGGGTTTGTACCCAGTTGCCCAAGCGGCTGCCAAA GGTATTGATGCAGCGGGTGGTTCGATCGCCAAGCTGCGGCGCCTTATTGCTGATGGCCAAATCAACTCGCGTGACCT CTTCCAGGGTATCCTGAAAGGCGGCCAAGACATTCAAAAGCAGTTTGAGCAAACTGTTCCTACTGTTTCTCAAGCTT TCCAAGTGTTGCGTGACCGTGTGCTGGTGTACGTAGGCACTTTGAACGACGCTATTGATGGATCTGAGACCTTTGCC CGTTATGTGCTGTCTTTGTCATCCAATCTGGAAAGCTTGGCTAAGGGCGTGACTGTTCTGGCGGTAGCTTTGGGCCC AGCTGCTTTGGCCGGTTCGCTGGCTTTGGCTAATGCCTTGCTGGCTCGTATGAGCGTCATCATTATGGCTCATCCGA TTCTTGCTCTGGCGTCGTTGATTGCCGGCTCTGTGGCCGCTATCACGTTGTTCGGCAAGAAGATGAACGATTTGACC AACGTTATCGACTCGAACGCGTCTGCTCTGGAGCGTCTTGTCGCTACGTTTGATGGGGCTCAAGCCTATATCAAGGC TGCTTGGGAGAATTTCCCATTGTGGTTTGGCAACATCATCCGATCGGCGATCAACTATGCGTTGGAAGCTATCAACG AGGGCGCGAATTCTCTCCAACGGTCCATGAAAGAAGACCTGGATATGAGCGAGAAAATCTTTGGGGCTTTGGGTCTC GGAGATTGGGCTGCTGCACGTCGTGCCAAGTACGAAGCAGCTGCCAACGAATCGATCCAAAAGGGCTTCAAGCTTAC CAATCCAATTCCTTTGCTGCCAGAAAACAATGACGCTTTCGCTAAGGCTGGTAACGCTGCTGGCGAGGCTTTCAACC AAGCGTATATGCAGTCTTTGTTTGACTCGCAAAAGCGCCGTCAGTTTGTTGGTGAACAACGTGATTTGGACGAGCGC TCGAATAACCCCTTGGAGCCTTTCAGTTCTAAGGGGAAGGGCAAAGGCCGCAAGAAAGAGCTCAGCGACATCATCGA CCTGCTGGAGCAGCAAGAGCGTGGCCTTCAAATGGAAGCCGACGCTCGTGAGCGCTTGAATCAAATCAATCAGTTTG ATCGTCAAGTCAAGGGCGGATTGAGCGGTACTGAAAAAGAGATGCTGGATCGCAAGCTCCAGTTCATTCAGGCTCTC GAACGTGAAGCCAACCTGTACTCTGAGATTCGTGGACCTCAGGAAGATTTCCAGAAGAACTACGACGCTCTGAACCA GCTGCTGTCTCAAGGCAAGATCAATGCTGAAGAGTACAATAAGAAGCTGAACGAGATGCGCATCTCCATGCTTGAGC TTGATCGCTCAATGGAGGGAGGTGTTAAGCTTGGTGTCATGAAACTGGCAGAAGAGTTCACTAACCTGGGCTCGCTG ATTTCTGACACTATCGTCAATAGCTTCAAGTCTGCCGAAGACGCGTTTGTCAAGTTTGTTTCTACTGGCAAATTGGA ATTCAGCAGCTTGGTTGACTCGATTGTGCAAGATCTGGTACGCTTGGCTGTTCGCCAGTCTATCACAGGTCCAATCG CCGGCATTCTTGGAAATGCGATCGGCGGGTGGCTCGGTGGTGGCGGGGGCTCTGTCAACGTGGTTGGCAACGGTATC GGCAGCGGCGCTGGAAGCATGACAGCAGCTCAATGGGGCGGCTCTTTTGCCAACGGCGGTAACTTCCGAGTTATGGG CCAAGGTGGCGTTGACAGCCAGATGGTCAGCTTCATGGCAACGCCGGGCGAAGAAGTATACGTCCGTAGCCCTGGCG AAGGCATGAATGGTGGAGGCGGCGCCATGGCAGTGTATTCGCCAATCACCATCAACAACAACGCTTCGGATAAGGTT CAAGTTACAGCTCAACAAGAGCAAGATGGAGATGGTAATACCACTACCACCTTCACCATTGATTACTTGGAGCAACA ACTCGCTGGACGTATGTCTTCGGGTCGAGGCCCGCTGCACCGATCCACCCAAAACGCTTTCGGGCTCAACTCGGCTC CTCGAGGTTAAGATGGCAGTACCTTATCCGTCAGATGTTCTTCCTCTACCCGTCCGTGACGGGTATGAGGAGGCTTT ACAAAACCCTTTCACACGCTTTAAGCGTGACGACGGCAAGTTTCGCACTGTTCGGCGGTATACCGTGCAGCCTAAGG CTGTTTCTCTTACCTGGAAACTGACCTGGGACCAACTCAAGTTCTTTGAGGGCTTTATTGAGTATGACCTCAATGGA GGCAATGATGAATTTGAGATTCAGTTTGGTCCAAACGAACCGGTGCGTATTGTCCAGTTTGTTGGTGGACCTCCGCC TGGTGCCTCTTTTGAGGCACGTTCCAATCACTGGAAAGTAACTGCCAAAGTACAGTTCATGCTGCCGGCGCCTACGC GTCGGCCGTTGTCCTATTACCCAGCTTTCCCTGCTTCTTTGCCAGAGCCTGAGAAGGACTCCTACGAATACGGAGCT CCTGACCGGATGCTTATTGACCGGGATGAGCTGGGCGGTGGCAAGCAAAATGGCCGCAAACGGTTCTCGAGTGTCCG CACCGAATACCGTGTTAAGTGGCTGCTCGATAATGAGCAGAAGGCTACATTCGACGCGTTCCTGAGCGCAGATATAG CGGACGGTCTTGCGTACTTTAAGGCGCCGTTTGCTAACGGTATGGGCGCCACGCAATTGCGAGCACGCTTTACCAAG CCGCCGGTGGCTCAGCCTGAAGGGGCTCTTGCTTGGGTCATTACTGCAAGCTTAGAAACGTCGGAAGCTCCAGTCAT TTCCTCCTATGACTATATCTACCGCGATGGCCTCGTTGTTACTGAAGGTTTGACTTTCAGCGAACAAACGATTTTCA ACGTCTTTTATGGTCAAGCTTTTGAAGAAGCTTTCCGCTATGCTGAGACTGTGTCTTTTAGCCTGACACAGCAGGTT CCGGAAACCATTATTTTCTCTGAGGATGTTAGTTTAACGGCGACGTACGTTAAAATACTTGAAGAACAGCTGGTATT TGGTGAATCCGGCTTCATCTCCACGGCTGACTACGTGGACGACACATACTTCGCAGAATCCTATGTCGGGTATTCTG TTTCCTTCTAAGGTACTATCATGTTGAAATCCGGCCTCATCTGGACTGGCGAAGTCTACTTCGAACTCAATGGCGAG CTGTTCTATAAGCAGAACATGATCGTGGATGCAGGTTTGAGCTTTGCTTCAGACTCCATCTTCTTGCCCGCTACAAC CGGCAAGTTGTCCTTTATTGGCCTCGGTTCTGGCACCACCAATCCTGCCGCGGGTCAAACGGCTCTTGTTACCCCGA TTCCTCTTGCTTCGGGTGGCACGGTTTTCCGCAAGGCTTTCGATGCTGCTCCTACGCGTGCGGGAGCTGTCACGACT GTCAACACCACGTTTGCGCCTGGCGAAGCCACCGGCAACGTCAATGAGGCAGGCCTGTTCACGGCTGTATCGGGTGG TGTCATGTTCTCCCGCGTGAAAACTACGGTCACGATCCCCAAAGACGAAAACGCTGAATTGCGCGTGCGGTGGGTCT TGACGGCCTCGCGTGCTGCCTAAGGAGTAGGATATGCCCGCAAAGACTATGGTATTGCGGGCTGCTAAAGGCAGCCC GCTCACCAATCCCGAAATGGACGCGAACTTGCAGTCAGTTCTTGACTACATGAACGCCCAACTTTTGCCAACGACGG CTCACCATCTCGATAACTATGATACGCCTGGAAACTGGTACCAGGGAGCGGGGGGCTCTGCTACTGTAGAGCAAGGT TATCCGATTGCTGGTGGCACTGGCTTTTTGCGTGTCAACACCTTTAACTCTGCTACGTGGCAAGAATACGCGGTCCG TACTTCCCCCTTCCGCTCGTATTATCGCATGAAGACCGGCAGCGGCTGGGGAGGTTGGCGGCAAAACATTCAGATTG GAGACGGCGAACAAATTCCGCAGCCATATATCCCGCCGCTTTATACCAGCACGATTTTTGCTGGTACTAATGCCAAT ACGGTGACGGCTCCGGGAACCTACGCTATTCAGTCTGATGCAGATGCTACTGCTGCTAACAACTGGCCCACGCTTTC TGCTGGAACGTTGCTTGTGATGGCCTCCAATTCGGGGAACAACCAGGTTACTCAAATTTACACGACTCGAGGTAGTG GCGGGTTTGTTCGCCAGTTTGTGCGAGTGCGGTTTGATTCACCAGCACCCAACACCTGGGGCACATGGCAAGAAGTG GCGCTGGGCTTGTGGAACGGAGTTACGCTGAATTTGGCGGGTACCGGCTCTGGAGCTGTTATTAGCGGAGACATGCCGGGTATTTTCTCCGCAACTTCAATGCGTTTTAAAGGCTCTGTTTCGGGAGGCGGTACTTATGTTCAGGCTGTACCGC CTGCGGCAGGAGCTACTGCGGCCTTTCTTTGCCGTCAGAATGAAACGACAAATGCAAGTTTCGTTATGCTGGGTCTT GACACGACTGCTAATGTGGCCCGTCTGGTGTTCAGTCGGCATGGTACCGGCACGCCTCTTGACGCCCTCATTATTCA AAGTCAAGACCAGCAAGTTGGAACCGTTAGCCGATTTGGCGGCTGGGTGCTAGGCGCTAACCCCGCTGCCCGTGCTG CAAATACAGCTGCAACTATCACCTATGCCGGGGGCGGTACGCAATGGGGCTTGTTGATGGCTCCGACTGCACTGGAA GGAGCCGCTGCAATTGCGTTCCAAAGTACTGCGGGCATTTTGTGCGGTTCTATTACCACAAATGGCTCTGCAACCGT TTATAACACCTCGTCCGATTACCGGCTAAAAGACATTGAGGGGTTTGCGGATAAACAGGCTGGCCACCAACGGATCA TGAGCGTGGTCATTCATGATTATACATGGAAGGCCGATGGAAAGCCCGACCGTGGTGTCGTAGCGCATGAGCTGGCG GTTACTCACCCTAATGCAGTAAGCGGTGAAAAAGACGCCATGATGCAAATGCCTGGATATGAAGATCAAATCATGCC TCAAGGCGTAGATTATTCTAAGCTTGTACCAGATTTGATCCTCGCTGTACAAGCCCAGCAGGAAGAAATCGAGCAAC TCAAGCAAGAAATTCAGGCACTGAAAGCGGGGAACGCATGAGCTGGGAACAAGCAATGAAAGAGGCGTACGCCTCGT CTCCTGTAGACGAGGTGCCTCTTGACACCCTTGAACTTCGCCACTCTGAATTCGTGGACGAGTTTGGGGAGCCAACC GCGATCCGGGTGGTTCAAGGCTACGAAGACCAAACTCTTGGGCTCGAAGCTGATGCGCCGCTCAATGGTGGACAGAT GGTCAAGTTCATGGCCTGCCGCTTCAGTCTGGTGCTGCCGCGTATGGAAGAAAATGCCATACCTGAAATCCAGATTA CCATTTCCAATGTGTCTCGTGAAATCACGAAGCACTTGGAAGCGGCGATTGCGGTTCTTGAGCCCATCGCGCTGACC TATCGTCCATATCTGTCGACGGTGCCTGAAGCGCCACAAATGGATCCACCGATCCACCTGACACTGAAAAAGGTCAA GGTCGATATCTTCCAGGTTACTGGCACTGCCTCTCTGGAAGATGTCCACAACTGGCCTTTCCCCTTCCGCAAGTATA TGCCAGATGAATGGCCAGGACTGAAGCGATGACACCCGAACAAGTTACCAGCTACCTCGACGGAACCTATGAGTGGG ACCTCGAAGGCGAAGGGCCCAAAAAATTCAACTGCTGGAACTTCATGCGCCACATCCAGCAAGAGTATTTCAATAAA GACGTTCCCGAAGCCTCTCTCGGCGACGAAGAACTTCTTCGTGAGATGTTCGTCCGGCATGTGCAAGATGGCATCTG GCAACCTGTCTATCCCCCGAAACATGGCGATGCGGCCCTTCTGAAAGGCGGCTCTGATCCGCACGTCGGCGTCTTTC TCGATATCGATGGCGGGCTTGTTCTTCATGCCATGAAAGACTACAACATCTTGGCCACACCCCTCCGCAATCTGCGC GGACTCGGTTTCGGACGAGTTATCTACTATCGCGTAAACAAGGATATCACCGATGGCAACCCTCCTGCTGCATAAGA ACGCGTTTCACCGCGGGGCGGATACCGAACAGAAGCCGGTACGAGCGGGTGTTCGCTACAGCACCCTGCTCCGTCAG CTGGATTATATCAAAGGCCGTGGTAAAACCATGACCCGTCGGTTGCCGTTCCTGGTGGTTCGCAATGGCCAGCCACT GCTCGAAAAGCAATTTTCGACGCGGGTGACCAAAGACGATCATATCTCCATTATCCACATGCCTAAAGGCGGTGGGG GTGGTAGCAATCCACTTCAAGCTATCATGATTATTGCTGTGGCCGTAGCCGCAGCGTACACCGGCGCTTGGGTAGGC GGCGCAAACGGTTTGGCAATGGGTGCCGGTTGGGGTGCTGCAGCTTCTGCTGCTGTCATGATTGGTGGTACGCTCTT GTTGAGCATGTTCTTTCCTCCACCAACGCCCTCTGCGCTAGATTACTCACGGGAATCGGCAAGCCCTACCTATTCCC TTAATGCCCAGGGCAACACCGCTCGACTTCTTGAAGCCATTCCAGTTTTGTACGGCCGATTCCGTACCTACCCGGAC TTGGCTTCTTCGCCGTACTCGGAAACTGTTGGAAACGAGCAGTATTTGTACCAGCTGTTTTGCATTACGCAAGGGCA GATGGAAGTTGAAAAAATCATGGTCGAGAATGATGATATCTCGTCCTATGGTGAAATTCAATACCAGATTGTGAATC CTGGTGAGGCTGTCACGTTGTTCCCTGACAACGTTATAACCAGTATTGCAGTCAACGGGCTTGAATTGGAACCTACT CAGATTTTTGGGCCTTTTTCGGCAAGCGGTCCTGGCGTACAGACCAATTTCATCGCCGTGGACTTGTTCTGGCCCGG CGGTGCGTACTTCATGGATGACCGTGGCCGTTTCACAGCTTCGACTGTCAACGTGCGCTTTGAGTACCAGCAAATCG ATGACACTGGAACTGCCATCGGTCCCTGGAATGTGTTGTTTGAAAAGGACTATACCTTTTCCACCAGCACTCCTCAA AGTGCGACGGAAAAGATTGCAGTACCTTTGGGCCGGTACCATGTTCGCGGTTGGCGTAACACGGGTATCAACCCAGA CAATAAAGAACAGAACCGGGTTAACTGGTCTACTCTGCGCGGTTATGCCCAATCTCAGCGCAACTATGGTGACGTGA CCTTGCTGGCCACTATCATGAAGGCCTCTAATAACCTTAACCAGCAAACTTCGCGCCGTATCAATGTGATTGGTACT CGTAAGCTACCGGTATGGGACCCGGTTAATGGCTGGAGCGTGAATCCAGTGCCTACCAAGAATCCTTTGTGGGCCGC TTGTGACATCCTGCGCAATTCCACGTACGGGCGCCGCATGCCCACTTCTCGCATCAACGTGCAAGAGGCCTACCGCC TTTCACAGGTCGCGGCAAGCCGTGGGGACGAGTTCAACGGGGTATTTGATAGCACGACGCAACTTTGGGACGCACTT TCCAAGGTTCTTCGTGTTTGCCGTACTGTGCCTGTGAATTACGCAGGCCTGGTGGACTTTGTCCGCAACGAGCCGAA AACGGTTCCTACGTACATGTTCCAGCCTCAAAACATGCTGGAAAACTCGTTCAGCACGGATTACTTGTTTGTGGACA CATCCTCCACGCCCAATTACGTGCAGATCGAGTACACCAATGCAGAGACCTGGTCACAGGAAACTGTTGACTGCGTG CTGCCGGGGGTGGCTCCTACTGTTCCGTCCAAAGTGTCTATGATTGGTGTCACCAATCGGGCACAAGCTTGGCGTGA AGGCATGTCCATGGCTGCGGCTAACCGCGACCAACGGCGCATGATTAGCTTCACGACTGGCCGCGAAGGTTATCTGC CTCGTTATGGCGATTTGGTTCAAATCTCTCATGACGTTCCGCAGTGGGGCTTCTCGGGTGAAGTTTTGGGTTTCAAT CCTGGCCCAGATCATCCTGAATGGGGCCTGCGTGGCGAATTGACGTCGAACGAGCCTTTTACCTTTGCAGCCGGATC GAACCACGCGATCGTCTTCAAGCGCCGTGACGGTTCGCCGCATGGCCCCTTCACGGTCGTGGAGCATCCGAGTGGGG ATCCGTTTAAGTGCGTGGTTCAAGGCACCGACGTCCAGTTGGACGATATCTACATTTCGGACGGTTCGCGCGAAGAG CTTACGCAGTATCAGTTCGGTCCTACCGAACGCCGTGGCATTCGCGCAATCGCGCTGTCGGCTACTCCGGATGGCGA CGGAAAAGTGCAGCTGACGTTCACGAACTATGCTGATAGCGTGCACTCGGCTGAGAACGGCGGCGTCGTACCTCCTC CTGGCCCTGAGTCGAGTCTTCCTGGCATTATCACCGTGCCTATTGTGGACTCGGTGACCGTCGAACTTACGCCTTTT GCTTGGGTTCAAAATATCGTGGCCAAGCCGGCTCGTGGCGCCTATAGCTATGAGTTTGAGATTAGCCAGGATGGAGT CAGCTGGTCCAATCTCGGCATTGCCTCGATTCCTTCGATGCAAGTCAATCTGTCTGGTGGCCTCTGGTATGTCCGAG TTCGAGGTATTGGCAGTTTGACAGGTCCTTGGGCTACTTGGGTCGGCACGATTGAGGCTTCTGTACTGCCTGTGTCCCAGATTGACCATGTTAATATCACGGGCCAAGTCTTTGCCATCAATCTGGAATGGGCTGTGCGGGAAGACGACTTCCT GGCCGAGTCAGTTGAAATCTATTGGGGTACTACCAATATTCTTGGTAATGCCACCAAGCTGATCGAGTTACCCCTGC CTGCAAGCCAGTTCTTGGTTTCAGACTTGGGTCCTGCTGCCCGTCGGTATTTCTGGTTCCGTGTCATTGACGAAGCA GGCCGCGTTGGACCTTGGTATAACAACGGCGTTGGTCTGATGGGACAGTCGAGCGATCAGGCTGACATCATCATGGC GTATCTCGATGGCAAGATTACCGAGACGCAATTGGCCCAGTCCTTGCTGACCAAGATCAACTCCGGCGGTGAAGCGG CCGTTGAAATCGAGGCCATTGAAACTGCTTTGGCAGCCATGTATACCGTCAAGACGCAGTTGACTGCTGGCGGTCGT ACGGCTTTGGCAGGTATTGGTGTTGGTGTCGAAAATAATCAAGGTGTGCTAGAATCACAAGTGCTTGTATTGGCCGA CCGTTTTGCGGTGGGTCGATCTGACGATGTAACTGGTACCTTTAAGTCCATGTTTATCGTTGACGCAGGCAACGTGT ATATGGATACCGCTTTCATCAAGAACGGTTCTATCACCAACTTGATGATTGGTGACATCATTCAGTCTAACAACTAT GTTGCTGGTGTAGCTGGGTGGCGTCTCCATAAGAATGGCACCTTCGAAATCAATAACGCTTTGCCAGGTGGAGGCCG TTTGGTCATTGACGCGCAATCTGTTACCGTGTATGACAACAACGGTATTGACCGCGCTCGTTTTGGATGGATTCCCT AATGGCTTATTACGGCTATAGGGCGAAAGACGCCAATGGCAATATCTCGGTGGAGTACAACTACCGTATTCCTCGGA TTCTTGGCGTCGTTGCTACCGGCGTAAACCCAGGTTCTATCATAGTGCCTGAGTTTGCTGGTAGAACGCCCATGTTT CAACTTCTACCAGATAACGGCTCTTTGTCCACACCGCATTTGGCACCTGAAGTCTATATTAGCGGAACCACGCTCGG TTGGACTTTCAACTGGGCAGCAGCGTGGCGGATATCTGCCCGGATTGTTTACGGAGTATTAGGATAATGGCAGATTA TGGCTTTCGAGCCCGAAACGGTGTAAACGAGGTGCAGCTTGACAGCACCTATAAGAATTTCTCCCTTCGGGCTCGAG GCATTGCCTATGCCACTCAAGCAGCTGTTCATGCAAGCTTTAAGTTTGCAACAGTTGTTGTGTCGCCTACTATTGGA ATGGTTGGCTTCAGGTGCGCTCGACCTTGCACCCTGGCGAGTATTTACCCGTCCGGAGGTAATCTTGTATTGAGCTT CTTGGTATACAGCCCAGGAGTTTCTGGAGAGCCGGTTTATTGGTATCTATTCGACGAGCCGGTCTATGGCTCGTCAA TGGGTGGTAATTATGCCATGCGGCTGAAAAATGCTGCCGGCCAAATAACCCATGACTCTCGCATGGACTATATGAAG TTCTCAGGCTTCGATAGCGGAACTTTGACTGGTTTGCCCACTACTCAATCTAGTGGAACCCCAAATTATAAATTTGT TACATATCCAGGTACACTGCCCGCAGTAGTACAAGGGATAACATGCAGCAGCCAGGAAGAAGTGCCGATCGGTGTCG GGCCTGGGGTGCAGTACATGCAGTTCTATTTCTGGCAAATGTTCGCCCAGATAAACCAGTCAATAGGCACAACTCTA TGCGTTCAAGACTTTGGCCCTAGCTCTACGGCTGCTAACATATTACCAATAAGGCGCGAAAACTACTCGTTTACTGT CATCGATGTGGCTCGATACGGGTAAAAAGAAGGGGAGCCGAAGCTCCCCTTTGTTCATTCCGGGTCCTTTACAATAG GCCGGATATTTCCGCAATAAGTGCCAGATTGAGCACAAGCATCGTTACGATACCCAGGCCCATAATCCAGTTTTCGC CCGCGGACATGCTCAACGGAGACGTGTACGTAGGTTTGTCCAGACCCGCGAGGGGCAGGGAGAGAAAAGGTCTTGGT GGGCGTGACGACGATGACCTTATCGAGTGAACGTTGCACATAGTCGATTCCTCCAATCTCCTCGATTTCCGAGGCTT TGGCGTTAATGGGCAGGAAGCACAGAGCCACCAGCAAGATCAGGAGCAGAACTCCCAGAAACCAGGTCAGCGGATTT TCCCTTCCGAACTTGGCGACTTGTTTCGGCGTCAAGTAGAGGTTACTCGTGCCAAAAGCTTCATCCGAGGAACGGTA CGACTTGCCAGACCAGTTCGGATGATTGAGATTGATCTTGCTCATTTCTTGCTCCCTTCAGCGAGCATTGCTCGCAG TGTGGTTTCAGTTAGTATGACCGCATTGATCTGCTCAATCCGGCAATATTCAAGCTTCACGCCGTGGGTATCGCCAA GAGCGTTGGTATCGTAAATGAAAACGCCAGGCAGCCACTTCATAAGCTCCAGCTTTCGTTGTTTGGATCTCATAGCG CTCTCCGTTCACAGCATGGATTCATTATAGATCTGGACCCAGATGCCGTATACCAGCATGGCGTAACTGCTGGCCGA TCGGTTTTCGCCCACGCAATATAATTAAGCACTAAATGCAGTTAAAGTTGCCAACGTTCAACCTTAAAAGAGGAATA CCTTGGATAGCACGATTCTCCAATGGGTATTCGGAGGTGGGATTGCTGCAGGAGTAGCAGCAGCGGCAGTGCGGCTG ATCCAAGGTATGGCCCTTAAAGATCAAGCCCAACGCGCAGACTTGTCTGGAAACCTGTCGGTGATTGGTAACTATGG CTCGTTCGTGGAACGCCTGACCCAGTCCAACGAAGCCCTTATCGCCCAACTAAAAGAATCTCAGGCGGAAACTGAGC GCTGGCGCGCTCTGTACTATCAGCTCCTCGTGGAGAAAAGCCATGTCAAACAAGATGAATGAGGCACTTTGCAAGTT CAGCACCCGACGCATCGGGACTCTTGAGCGGTTGTACTTCTGGCTCATGATGATTGTTTCGGCAATGGCAGGCGTTG CTTTGACGCTCAGCATGTTGACCGGGCAGTCCATCGTGGAACAGAACAAGATGCAGGAGATTTATGACCAAAGTCTC CAGCACATCAAACAAGAGGCTGATGCTCGTGTCCAAGAGGCCAATGAGAAGTTCAAGGCCATCATAGACCGTCTGCC ACCGAGTGTAGTCACCTCGGCGGTGCGAGGAGCCAAGATTGAAATTAAGCCCTAAGGTCTACGTCCTAGTGACCTTA GTTGTTATCGGTCTCGCCGCGTGGCTCTACACGTGGCGGATCAGTGCCGCAGAGCAAAGAGGCTATGATAAAGCCCA AGCTGAGCAGACTAAGGCCACCCTAGACCAGTCTGAGGCCAATCGGGTCAAAGAAGCAGACTGGAACCGTAAATGGA ATGAGGTCCAAAAGACCCTCGCACAGGAACGTGAAAATGCGCGCCTTGCTCGTATTGCTGCTGATAGCCGGTATTTC CGGCTGCAAGAGTCCATCGCAACCGAAGCCGCTGGCGCCGCCGCGCTCGCCAAATCCGCCGGCATCTCTGTACGTGG AAGTTCCTCCGTCTGGGTGGTACTACGAGAGGTTCTCGAGCGATATCGAGAGGTGGCAGGAGATGCTGACCGATACA CCAGCACCATCCGTGAAACCAGAGGATGGGCCAACATCGTAGAGGAATCGAAATGAACCTTACCCCGCACTTCACTT TGGAGGAATTGATCCACTCGGACACTGCAGTCGCGCGCGGAATCAAGAACGTTCCTACCGAAGCTGAGAAGGCTAAC CTTTTGCGCCTGGCGCAGACTCTGGAAGAGGTCCGTAATGTCCTCGGCGGCAAACCGGTCATCATCTCGTCAGGCTT CCGGGGTGAAGCTCTCAACAAAGCTGTCGGCGGCGTACCAGACTCCGCCCATCGCCTCGGCCTCGCCGCCGATTTCG TCTGCCCGCTCTTTGGAACTCCTTACGAAATTTGTAAGGCTATCCAGGCGTCGGGCATAAAGTTCGACCAGCTCATA TACGAAATCGGCCCGCGAAACCCCTGGGTTCACCTGGGGCTGCGGGCCGGTGGCAGTCTGCCGCGGCAAGAAGTTCT TACGTGGAAGTCTGGTCTTGGCTACCGGGCAGGGCTTCAAAAGCTGTAGCCGTGATGTGAAGGTGGGAGCGGAAGTC CGCACGGGCGTCTGCCGGTTGGCCCTCAGCAATGACAATGCTGAGGGCCTCGCCATTTGTGACCTCCTGGAGCCCGC CCAAGTAGCCATAGCGTTCCATGAACTTCCGGTGGGTCGCAGGGGTGTCAAACGAAAGGACCCGACGCTTGCCGATCCAGTTGTGGGTAACGAATTTCATGTCAAGGGTCCTTTTAGGTTTCAGGACGCGCGCACGCATCCAGCAATCTTTGTG GCGTCCAGTCCGTCGCTTCACGCGAGCAGAATCGGATTTCTTCTTCAGTGATGGGTTTTTGAAAGGCCAGGAGTTCG CTGCCAGGGATGAGGTATTTTTTGCTTTCACGGCCAGAGCCTATCTGCAGTAGCACGTACGAGGTGCCGCCGGCATG ATAGCGGTTCCTGTGCCATGCTATTTGTTCAGCGGTGATATTGTGCTTGATGGGCGTGGAGCTACGAGCTGGTCGAG CCACCGCTTTGAGCTCAATCCAGAATGAGAAACTGCTAGGCCAAATTTTGAGGCACGCCTCCACATCAGGAATCCCG AGCCCCGTAGAGCTCTCGATCCGCTGAATGTGGAGTTCGCGCCCAAAGTGTGCCTTAGCCTCACGAACCCAACGCCA CAAGTTCGTCTCGGCAATCTTTGGGCTTGCTGCCATCAGCTCATCTCCGTGAACGTGATGCCGCTCTCATGCATCAT GAGCAGCGAGAACTTATGGCTTTCGCCCCAGACCGGATGATCTACTTCCGGCGGCGGACTGACGATGCGGCCAATGC ACACTTGGCTGAGGGCTTTCATGCACTCGTTGCACGGAAAACGCGTGGCGTAAAGCGTGGCGTCTTCCAGCAGCATC TTGGTCTCGACGTCGAAGATGGCGTTGAGTTCAGCATGGATGATGAGCCCGCGCTTCACGTCTTTGGACGCGTACCG ATCCGGCTGGTCAAGCACCTTGGACGGAAAGCCGTTGTAGCCCATGCCGATGATTTTGCGGTCTTGCACGATCACGG CACCGACCTTCCGCTCGTCCTTGGACCAGCCTTTCACCAGGTGAGCCATTTGGATGAAGCGCTTATCCCATTTGTAC TGGGACGTTTGTTCGGGCTTGATGTTCATCGAGCCCCAGTCAAGAGCACCAATAACACGGCTCATGCTATCACCTCC GGACGGCAGACGTAAGATGGATGGACAGCACGACTGTCCGCGACTTGATAATGCGCCACGAAGTCGTCCGGTTCCGC TTCGATAGCTGCGAGCGGGAACTTCTCCATGTAGATCATCGGCGCCTCTTCTTGACGCTTCAGCGCTTCCATGGCCA TCTCTTGATGCTTCTTGTACATGTGAGCATGGCCGACCAGCACAGAGATATACCCTGGCTGAATGCCCAAGGAGTCT GCCATGGCAGTCACCAGAAGCGCGTGGGTCAGCATGTCGTAGGGCAAGCCGACGAACAAGTCCGAGGAACGCAGGAA ATAAGACGAGTGCAGCTGGCCGTTGATGATGTTGAGGGTGAAGGCCGCCGGGCAAGGCACATTCTTCTCGCCACGCG TCAACAGTCCATCGCGAGCCGGGTCCCATGCCGAGATGTAAATCTGGCGGCTGCTCGGGTCCATTTGCAGAGCGTTG ATGGCATCCTGGAGCTGATCGCGGCCGAAGTGGTTGCGGTAGCGGTAGCCATAAGCGTTCTTGACGCCAATGAGCTT GTTGCCATTGAAGTCAAAGGCCACAGGCTCTTCGAACTTCTCCCAGATAGAGCAATGCTTCTTGATCCAGGAGGTGT CTTGGGTGCCTTGAGCGAACCACGCGCACTCGGCCGCTGCCGTCTTGATGTAGGTGCGGCGGAGGTCTATGGTCGGC GCCATACGATTGGCGATCCAGAAGCCCCAAGAGAGGCCACCAGGCATCGTGCGCACGACTTCACCCGTGCGCTCGTT ATGCTGCTCGACGATATTGGTACCGTCGAGCATGCCCTTGATGATGTGGCGGTACTGCTTGGCGAAGTTGCTCATGC CTTTTCCCCAACGGAATTGCGACGGGCCAGCTCGGCGTAGCCGCCGATGTCTTTCCAGTTGTCGTCATAGGACGGAT CACCCTCAACGATGCGGCCGATCTTCTCGACGAGCATGGTGAGAGCCCATTTGCCCCACGACGGAATGGACGGCCAC TTGGGGTGCTTCTGCAGCCGCTCCATGAGGTCGACAGTCAGGTCAGCACGACCGCAGAACGTGCCGTACAGCGCCGA TCGGCTGTCCACGAGCTCTTCGGACGACTGCTTCTGCGCTTGCTTGTTCAGATCGTCGTAAGCCGCACGCTGACCGA CAGACGGCTTGCCCTTGTGGATGATTTCAGAGGCCGTGTCTGCCGACACTCGACCGTCTCCTGCGTTGTAGGCTTTG ACCAGCTTGGCTTTCTCAGCCGCAGTCAGCTTGCGCTTGGCCGCTATTGCCACGTTGTCGATGTAGATTTGCAGATT GGATCGGCGGGCCATGTATCATTCTCCGTAGATGGCTTTGTTGATGTCGGGAGCTTTCCAGCCCTCGGGTTTGACTG CATCGTGATTGCCGGCGTTCGGGCGCTTTGCGACAGTGCCGTTCACTTTCAGCATATTAGCCTCATGCACGGCCGAA AACACCCGCGAAGCATTTACATGCATCTCGGACAGGGTACTGATGGCGATATAGATGAGGTCGATGAGCCCATCAAC CGTTTCGCCCATGTCACGTTTTTCGTAGGCCTCGTTCAGCTCGAGCAGCTCCTCGGAAAGGTGCTCGATACGAGCAG CCATACGGCTCTCGCCAAGCAGTCGCGGTGCCATGACCTTGACTTGTGCCTCGCCATCGACCACCGAAACCTCGTGC GTGCCGGACGGAACCTGCAAGATGTTGAGGTTGAATTGGTTGGTCATGCTTTGTGCCAGCATGAGACTGATGCTGGT GGGGCCTTCCGGCAAAACGGCGTATTTGGTTTGGTTCACTTTCAAGCTCCTTTCTTGGTTGCAAATTTTTCAAAGCG GCTATTCACTTTTTGGATGCGCTGACGCCGCTTTATTTTGATGATGTACGAAGACAGTTCCTTATACATACTACGAC GAAGATGCCAAGGAATAACTCGGTTCTTAAGCCGGCGGATTTTCATGCTTCTTCCTTAAGGAACGGATCGACCTTGC CAGGGACAAAGACAGTAGCGGTATTGCTGGCAAGGGAATAGCCAATACCGTGATCTTTTTGAAGAATAAAGAGGTGG CTCAGAATGTTGGAGCGAGTGGTCTTGAACACGGCCATAGCCGCGTGCACCGACTTGGGCCCGCCTCCGTCCTCCAA GAACCACGCGAGAACTTCACCGCGCTTCGAGGTTCTTTTGACCGGCTTCTTCAGCTCCTCTTCGGACTGTTTGCCCT TACGGTTGCTCTCAATAGCCGGCTCGATAGGATCGCCGAAGTCATCATATTCCAGGCCTGCCGACAGTTCCGTGACA GGCGCCTCGATGCCGAAAGCGCGCAGTACGATCGCAGCCATGCCGAAGTCACGACGCATGCCGAGCTTAGTCCACGT GGCCCACTTCTCGAGCAAGTGCTTGCCCAGAGATGCAATATTGAGCTTCTGCTCGGGCGTACGCAACGAGGCATATT CGGCCGAGCGCTTCGAGACCTGGTAGGTCTGAAAGGTGAACGGGCAGAAGATCGTGCATTGTTTGGGGTTGTCCATG ATGATAACATGGCTCCAGCCAATCGTGGGCGGATTCTGCACCTCGTTGATGCGTGCCGACTTCGACTCCAGGTCGCC ACGCGCCCAGTACACGCGAGCCCAGCCGATGTTATCCTTGATGAGTTCGTACGAGGGGACAGTCATTTCAGTGCTCC AAGTTGTTCAGTCATTAAAGATATTATAGCCGAGTTCTCGGTAGATAACAACCAATGCTGTGTAACAGGAACAGGAA TAGAAAAAGCCCCGAAGAACTCGGGGCTTTTTGGCCGTTGACGCAGGCTGACGTAAAGGCTTATTCGAACTCGGCGT TCGCGTCGGCGCCGGCCTTGTCACCGGTGGCGGCCGCTTGCAGTTCTTGCTTGGGGTCGTCCTTCTTGGCCTTGGCC TTCTTTTCCTTCGGCGCCTTTTCGACCTTGGGGCGTTCCGGCGACGGGAAGTTTTCGCCCTTCTTGCGGAGGTCGTT GCGATACCAGGCGATCGACTGGACCGTGGTGTTGGCGTCGGGGAATTCGGCCTTCACTTTGGCCAGGGCGTCGGCGT TCGACAGGCCGGCACGGATGGCTTCGCGGGCGACGGCGCTGATGTTGCGGACGGGGGCCTTCGGGGCCTTTTCGGTC TTCGTGTCTTCGGTCTTCGTGGCTTCGGTCATGATCGTGTCCTTAGAAAAGTGACTGGGTGGTGATTCAAAGATGGT GTAACTAGATATTAACTTCATCTGCTCGGCACTTAAACCAGCGTTTTCCCAGTGAGAAACGCCTGCAGTCCGTGCCG GCTTACATAGTCTGAGAGGGAAGTCTTCTCAGACAGTGAGTTCATTATAGACATGTCCACAGTGTCTACAGCCTGCAAATCGATGACGTCGATTGTATGTCCACCGATATGGGTTGCACGTTCGTCCGCCTGACGCCGGTGGATCAGATCGTAG GTGTGGCTATACCATATAACAGTCTTGGCCACTGAGAGGTCAAGGCCTCGTCCGCCTGCTGCAGGTTGGCCAATGAA AACAGTGCACTCGTCGTCAGTCATGAAGCGGTGCATATTCTTCATGCGCTGAGGCGTCGATATTCCGCCATGGAACT CTACGTACTTGATGCCAAGCTCGTCAAGCACTTTCTTGACCCGCTTGATATCTTCATGGTACCGGCACCAAGTAATG ACCTTTCTGCCATCCAGCAGCTGCTCCTGGATAATTCGACGGTAGACTTCTGCCCGCGGGTTCGGGAGGTCTGTTAC TTCCCCTTCTGCGTCAACGAAGAAGCCGTTGGAGACTTGCTGCAGCTTGATGGATTTGACCCCACCAGAGAAGACGT CTGTCAGGAAGATATCCCCATACAGCCCTTCTTCTTCCAGGAGCTTATCGCATATGCTGGTATAGAGCTTGCGTTGT TCCGGCTCAAGCTCGAAGAACTCATCAGCCCGCACCAACGTCGGCATGTCATCACATTCCTCGCGCAGCACGACTGA GGCATATTGAGCCACCAGCTGCTTCAATTCGGTTTGATTCCGGTACTCGTCAATGACTCGCACCCGCCGAGCATTGC CTTGACGGTCGTAGACAGCTGCGTTCTTGTAGGTCGCGAAGTGCGCCTCGAAGTCAGAATACTTGGTAAACCCTAAG GCATGCTTCTTCAGAATCTCCAGCTGTGAATAGGCAGCCAGTGGAGCATTGTCAGTGAAGGAGCCCGTGAGAATCCG GCGGTACTGTACATGATCCCGCAATTGAACAGCTAGCTTGGTACGTTTGGAGCTGATCTTGCGGAAGTCGTCGCTCT CGTCCACAATCAAGAGCGTGCCTTTCTTGGCTTGGCCGAGGAACATTGAGATGGACTTCTTGGGCCTATCTCGCCAG CAGCTCTCAGAGTTCATGCAGTACCAGCGCAGACTGTTCCTAGCTGTTCCTTTTGGGTTCAGCACCAAGTCATTCAG TTTTCGCAGGTACAAAGGCTTGCGAGACTCAGAGGATACCCAGGAGCAAACCTCAAAGGGCATTGACTTCCAAGCGT GCATAGGCAGCTGCTTGATTTGCCAATTGAGATGCACGCCGTTAGGCGCCAGCACGAGCACCTGGTCAATTTTGTCG TCCACGAAAAGGGCAAAAGCCATGTCAATCATGGCCTTTGTCTTACCAGTCCGCATTTGCCATAGAAGCGCACGGGA CGGTTCATTGCGGAACTCAAATTCGCGCGCTTGGTGCTTGTAGTGCTCAAAAACGGGTTCGTATGGTCCCATTGCGA ATTGCCTCGTCTGCTTTCTTAAATATCGAGCCGTAGTCTAGGGCGTCAGTCTCAATTTGGATAGCTTCACATTGCTC GAAGCACCGGCCGTTGACTGAATAATGCCCTCGGACGTGGTCCAAAATTGTTGTGCCACCCATCAGTACCGTATACT TTGAAGTGAAGTCATCCAGTTCCTCTACTTCTTCTGTAACTACTTCCGGACGGCCTTTGATGCACACCAGGGTTCTA ATAGGCATCATCGTCACCAAATTCGGTACCAATCCTTCTCAGCTCTTCAGCTTCTTCTGCTGTGAACTCAACTTCGC TAAGACACCCAGAATTAAGCCATCCTATGAAAGTAGTACCTTCCATTTGGAGCACGTGGCTTACATACTTTTCCAAC AGAGTTTTGTAGTCCATGTTATTTCCTGTACATGCGGCCTTCCCAGCCTTCAACCGCAATAGGCAGACCTTCACTCC AGTCTTCCCCGCGGGCCATTTCCTCTTCCATGTGTTTGTACGATGCGCGTGGATCATCGAGGGGTGCCTCGCCTACC GCTTCATCGTGCACGCTCAATACCAGCTCATAAAACGGAAAAGCCTCCAAGCGAAGCATAGACCAAGCCATGCAGTC TCGAGCCACCGCCTGAGTGACGTTTTCAGTCAGCATCCCGCCGTAAGTGCTCGTACGCTCCCACTGCTTGGTCGTGG CATTCATGACCATAAAAGTGAGGGTAAGCTTGAGCGAAGGCTCCTTATTTACCACGTCCTGCAGCGTCACCATCAGC TCTACATCCTCGAGCTGGGCAATGCGTTTAGCTTCTCGGAAAGCTCGGACAGCTAAGTCCTTTCCGTTAGGCACCGA AATGCGAATCGAATCCGTTTCGCTGACGGTATCGCCTTCTGGCGTCTGTACTGTTCGCTTAACGTCGAAGAAGTAAG TGGCGTCTTTTCGCAGCAAGGGGAAGGGATACGACAACGATCGGCCAGACGGCAGCTTGCAGTGCAGGAATATGCCG ACGCCCTCGTACTTCTTCGTGTACCAGGTCAGCTTGCCTTCCGGCATCTCCACCGGCTTACCTGTTTGCACTGCGGC GATGGCGCATTCCTCGATGTCGCGCCAGAACTTGACAATTGGCTTACGTTCGGTCCGGTAAACCTTAACCACGTTGG CGATAAACTTCTTCGGCAGGTGTACATCGAACTTCTCGGCGAGGTCAGCAAGGAATCGTTTTGCTCCCATGCCAAAG CCCAAGCCAAGAATTGCTTGTTTACCAACGAAGCGCTCGTCAGGATGAGTACTCTTGTGTGTTTTGTAGCCATAGAT AGCATCTGCCATAAAGCAGTAAACGTCATCACCTTTGCGGAAGACGTCCAGCAGTTCTTGGTCATTAGCCAGCCAAG GAAGAACACGACCTTCGATAGCCGCAAAGTCGCATACTACCAGCTTCTTGCCCGGAGGAGCGCAAATGGCGCCACGC AAGGCGTCAGACAACAGTTTGCCCACGTCGTCATATACCATCGACAGCCATTCCAGGCCGTAGAGGATATCGCGCCG TGCAGCTTCCATGGCTTCTTCAATATCCTTGACGCCGGTGGTTCCTTTAATGTCACCCCGCGGGAAATTATGAGGCT GCAGACCCTTACCAGACCATCGTCCAGTTGTGGCGCCATGGTACATCATCGAGCCACGCATGCGGTTATCGTCGCAT ACCATATCAAGCATGGCACGATACTTGGCCGTGGACGTGCGGTTGCCCATTCGGAGGATGATGAGCACTTGCTTGAC GACGTCTGGCACCTTGGGATCAGCCAGCACGCGGTCAACAGTCGTGCCCTTTGTGTCCTTAAGCTTGAGAGACTGGG TTTCGCACCAGGCCTTAATACGCGCACGTTGCGTGGGCTTATCTGCCATGCCACCAGTCAACTCAGGAAGCTTTGCT CGCAGATTGGAAGAGAACTCTTCATCGATCGCCAGAGCAGCTTCAGCCATAGGCCGATCAAGGTAAAGCCCACGAGT ATTGATGACTTGATCGAGCTCCCAAATTTCTTGCTCTTTCTTCGGGATATCCGGAAGAGCGCAAGATACGAAGTGCT CAGTCCGAACGTCAGTCGAGCAGTATTTGATTAGCCGACGGAACTCGCCCTCGGTGCCGACGAACATGCCGTTTCCG TCAGGACGGGAAAGTTTCATCATGAGCTTCCAGCCTTCAATATCCTTCTCGACCAAATTGCCCTGCTGGTCTCGAAT CTGCAGTGCTTGAGCAATGTTCTCCAGGGACCGAGGCAAAGCATAGTACGAGCCTTTTGCAGCCGAGCAGATACCTT GGCTGATAGGCAGCGGTTCCCAGCCGAGAGCCGGAACGCAGACGTTGTTCCAAATGGCGTATTCGAAGCCCCAGTTA TGTGCCTCGACTTTTCCGCCCTTTCTGACCCACGCCATCAGGTGTTTGAAGTAATAGGCGTTGTCCGGCGGCAAGTC AAAGCCGGTTACATAGGGGTTCCACCACTCATGCACTCCGTCTTTGTCCGGGTCTTCACCAGGCAGCAAGAATGAGA AGCATATGACTTCCGTGCTCTCGTCTCGAGCGTATTTGTCGGCACCAACTACGAGCAGGTCGGCCCGAGACCGCGTT TCAAAGTCGCCGGTGGCTCGGTCAGTATGAACTTTCAATTCTAGCTCCGCAAAAGAAAAAGGCTTGACTAGATTTTA CTCTGGTCAAGCCTAAAAAGTACCTCTGTTACGAGGACTGGGGAGGGAGGTCACAGTCATGTCGATGGCTGTGGGCT GCGCGTTAGGTCGGGCGACAACCGGAGCAGGAAGCATGACGACTTGGAGAAGTATCAAACGTCCTAACGCGCAGCCC GCAGCCATCGGCTGCGGAAGAGGCATGGCCAACCTCTTGGTACCACATGAAGATCACCGCCAGGTGACAACTTAATT ATAGTTTCAAGCTTTACTTCTTGAAACCTGTATTTTGGTCGGAGTACTAGGATTCGAACCTAGGACCCTCTGCTCCCAAAGCAGATGCGCTGCCAGACTGCGCTACACTCCGAAAACCTGCGAAGCTCATAACATCGCAGGGTCAGCACACTTC ATAGAGCCCAGGTGCATCGACGATCCAAGAAATCGCTGCACCACTATTCAGTAGCCAACTTACAGCGCCCTCGGTGA GAGGTCCCGCACGCACCAGCCCGGCCCGGGCTAAGATGAAGGCGCTGTAAGTTGGCGTCGGCCTAGAGAATCGAACT CTAGCGCTAGCAGGACCCGGGTTTAGACCTGTAGCCATATCCATGCCGACAATTGTTGGAAGGGCTTTATTACTGGG AGCCCTTGCCTTCAACCCGGCCTCCTTTAAGTAGAGGCTAACTTCAGGCCAATTCCTATGCTTTCGCCGCCTTGCGG TTGACGCCGGTGGGGGCTGCGTAGCTCATAAGACTGGCCGAGACCTTACTCGAAGTCGCTGCCCGGTTCGGCCGGAC CGTCGAACTCCGCTTCGCCCATGCCGGCGAAGTCGCTGGCCGCATCGACCTTGTTGTCCAGACGCTCGCCGCCGGCG ATGAACTGGATGTTCTGCAGGCCGAAGGCGACGCCCTTGCCGACGTTGTCGTAGGCGTAGGCGGTCATGGTCACACG AGCGTAGCAGCCCGGGTAGAACAGTTCGCTGGAGGCTTGCAGGTCGATCTTGCCAGTTTCCTGGTCAATGATCGGCT CGATCGGGTTGCCGTTGCGGTCGACGATGCCAGGACGATGCTTCGAGGAGAAGGTGATGAACTTCTTGCCCGGACCG AAGCCCGCGAGGTTCTCTTTCTCTTCGCCATCACGGATCGGCTTCTTGAAGTTCGCCGGCAGCGCCGACATTTTCTT CTTGAACTTGGCCATGGAGGCTTCATCGCCCAGCTTGACCATCTGTTCCCACAGAGCCTTCTCGTTGGCCGTGAACT TCTCGGGTTCAAAGATCAGCATCAAGCTGAACTTCGGAGCCGAGCCTTCATACGACGAAGCTGCGAAGACGGAGGGG AACGACACGCGGCCGACAGGGGTTGCGCATTTCACGATTGCCATAATATCCTCATAAGTTTCATACTGATTGACTGC GCACGGTTTTGTGAAGCAGTGAAGAGATTATAGACGTACAGTTTTTGGGCTGTACGCCTACAGTTTACGCCGTGGCT CGGCCCGTGCCTTTTTCAGAGGCCAGCTTCTTGCGCAGTTGTTCCTGCGAGAATGCAACCAAGCGGTTGTAAATCAT CTCGCGCACGGCCGATTGGATCGTGTGCTGGTAGAACGAACGCCGACGGTTCGGTACCGTTTTGGCGTATTCCAGGA CTTGCTTCAGCTCGCGTGCGCGGCGTTCATCTTTCCGTGACAACGTCATCGTAAAACTCCAGGGGTAAGGTTAATTG ACGGGCCTTAAAATCAGCTTCAAGGGCCCGGTTGCGATACCACTCAACCTCAGCGGCAGTGGCTCGATCTTGCCAGT CCAGAAGCTGCTGCTGCCCGGAACTCCAGTTAGCAGCGTGCTTCAGACTTTTCCAGCGTGGATTCATTTCCGCTCCA AGCCTACGTCCATGATAACGACGCGGCGGGTCCAGACACGCGAATCCGTGCCAGTGATGGTCGTGAAGAACTCACGG CCTTTCAAGGGCACTGCAAGACGGTAGTCAGGGTTTTGACGGAGGAACTCGTCTACTGAGCCCTTAAGGTTATGGGC CAGGATAACCGGGAACTTCACCGGCTGATCGCGACGGATATAGACAAGGGGAATATAAGCCTTCATGTTTGCTCCAT GTTGTGTGACCAGGTTCTATTATACCTAGGAGCAAAATAAAAAGCCCAGCAGTTAAGCTGGGCTATGGCCTATATGA TCTTGTACAGTCTGAATACATGCTCACGCAGCTTTGCCAATAAGGCCGGGCGTATGCCTTGCCCCTGCGTGATGATC CACCAGTACACGCTACGCCAGATCATCCAGATCGCGGGAAGCAAATAGACGAGCTTCTTGAGGTCAGTATCCGCCGA AGCCGCGTTAAGTCCATACACGTACTGCAGGACCTGGTAGCCGATGACCGCCTCGCAAAAGAAGCCCACCATGACTG CGAGGTCTACGAGAATCTTGATGAAGTGCATGGTCACCAAGGCCAGCTTAACACGAATCCAGCGGAACATGATTTAC TCCCGGTCGAAGTCTACTTGGAGGTCAGAGAAGTCTGCGGCCACGTCAGTGGACACGTCCAGCTCCTGGCGAGGGTC GGAGGTCGGCGCGATCGTCGGAGCACCTTCCGGCTTATAAACCAGCTGCTTCGGGGCCGTGTCCGGGTCTTGCAGCT CTTCGACAGTCGCGACGCGGTTGATATGCGCCTTCATCGCTTTCGAAAGCTTCTCGACCTTAGCCGGGCCCTTCATT TTGGGTGGTTCGAAGAGGTCCTCACGCTTGACGTCGGGGTCACCCTTGAGGATTTCCTCAACGAGTTCTTCTTCCGT CATGAAGTCCGACCACTTGCGGTTAGTCTTCTTGGCAACGACCTTCTGCCCAGGAATCTGCATCTGGCCAGTTAGGA TCAGATGCTCAGCATGAGCCTTCACCCGCTTCACCCATGTATCGATCATGGGTGCCCATTCTAGCGCGCGGGCGAAT TGCTTGGGCGTGAGCGGCATGGGGAGGTCCGTTGGGGCCGTGACATCGCCTTCAGCGTTGGTGCCGGGTACTTCGAT TGGGACCATCGCGAAGTCAACTCCTGCTTCTCGCTGGATTGCCTTATCAAATTCGGGGCACGTTGTGCCAGCACCAG GGCAAAACTTGCAGTGCTTACCTGCGGAGAGCATAGCGTCTCCTTCGCTCGCTCGATCCACGCCTTCTGCAAGGTGC CGTTCAAACAACTGCAAATGCTGTGGCGTTGTCTCCCAACGCCGAATAGGGCCGTCTTCGTGTGGACAGCGGGGTTG CACGACGATGAGCACCACACGGTCATACCCGTCGTATCCGCCCACGCGATGAGCTGCCCCGACTCCGTAGTATTTGA GCTGGGAGTTGTCTTCCACTTCGACAGGAACTCCTTTGCCGTGTTTGTAGTCCACGACGTAGAGAACCCTTTCTGTC CAGTCGGCGAGGACGTAGTCTCCCGTACCGAACATGTTCGGGCGAATGAAGGAAAGGTCCAGGCGGGCCTCAATAAA CTCTTCCGCATCAGGGTGCTCCTTGCGAAGTTCGTGGATCAGATCGAGGTAGACGTCGACAGCCTCGATCATGTCAT CGTCAATGACGAAAACGTTCGGAGCCGTAGGCTGAACGTCCTTGTTGGGCTTGAAGTGTGAAACAGCCCCGTTCTCC ATGACCATGGCAAAGTTGCCGCGGTAGGAGGCTGCAGACCGGAGATTGCCTCGCAGACACTTCTCAGCCAAGTCATG CGCGGCCGTGCCTTGCATGGCGAAGACCGAGGATTGCTGCTTGGGGCTCATATCAGCAATTCGAATGGAGCCCGGAC AGTTGAGCCACCGGCTGCTACCGGAAGCGGAGAATTTTGCGTGTGCCATGATGGTCCAAAGGAAACGCCCGGACTAG CCGGGCGGGGTTGAAGCTTAGGCCTGAAGCCCGTGGATCGGTTTGGTCTTGAAGGCCGGCGCATGGTTGAGGATGCT GACCACAGTGACCGGTGTCACGCCGTCAGCTGTCAGCACCGTGGCCTTGTCACCGACCTTGAGAGGCTCGGTCGAGT GGTAGGTGTAGCGCTTCTTGCTGGAGGCGAAGACGACCTCGACAAAGTAGACGTGGCCCATGTCAGTTGCGCTCCTC AGCGTCCGGGAACAACGGCGGCATGCCCGGGATGTGGCCGAAGGCGCCGGCGATCTTTTCCATGACTTCCTTCAGCT CCGGGTGCTCCTTGACCATCTTGGCCATGCGCTCACGGGACTTCTGGGCCAGTTCTTCGATGTGCTCGGCGATGACT TGCTCGTTGGACTTGCTGGACAGCATGTTGCGAGCCGTTTTGACCTCGTCCGATTCGCCCAGATCACCCAGCAGCGC GGCCAGTTGTTCCTGGCGCGACTTTTCGGTGATGGACTTGCGGAGGTTTTCACGCGCTTCGTCTTCGCGGGCGACCA GGGCGTCGTAGTTCGAGCGGTCGAACACCTGGGCCAGCCACTTGTACTTGATGCCTTTCTGCAGGTCAGTGACATGG GCGAAGGCATCGACCACGACCAAAGCCGGATGGCCCGCCGGGGTTATGACGACCGCGACGTCATTGACTTCGAGGTC ACCACGGTGCTTGTACGTGTACTGCTTGCCCGAGAGCACGCCGTCCGTCATGAAGCGGCAGACCGGATAGACGACGC CTTCTTCCAGCAGGTTGATGGCGTTTTGGATTTTTTCTTGCATTTCTTGCTCCTGGTTGATTTGAGTGTCTGCGTGTTTGTCAACGCATTGAGAAGATTGTACTGCCTGGGCCTCGATGTGAAACCCTGCATTCTTTGCTGCTTTGAGGAAAGC TTCGTCCTTCAGCATGGCCTGTGCGAAGCTGGCATCAAACGCATGATCCAGGTCACCCATGGCCACGCGCAGATTGC CTTCACGGTCATACTGGCGCACGTTGCTGCCTATGTAGACCATGACGTCCTTGGTCTTCTTGGACCGGTCAATGGGC TTGTCTACTTGCTCAGTGGTCGTGATATGGCCTTCAGCGTCGCGGTAGATGAGGGTCGGCCATTTCAATCCCTGCAA GCCTTCTACACGGGTCTTGATGGAATAGCACGCATCAAGCTGGCCAGCATCACCAGCGAGTTCCTTTGCCCGTTCCA GGTCACGGTTTTCAACCCACGTACGAGCAATGCGGACATCATAAGTTGGCATATTGCCATTATGCGTCATCTTGCCT TGGCGCATATAGGTCTGTTGAGCCGAGAGCGACAATGCCTGCGGGTAGTAGAACTCCAATGGAGTGTGGTCGCACTT CTCGTTGGAGATGGTGGAGTAGGGCTTATAGCCCATGTACACACCAGCCTGCGGCCACTTCATGGAATCAGACAGCA TTATCCGCCGTTCATTGCCAGGGAAGAGTACAGTAACTTGGAGGCCAGGAAAGCGTTCCGTCATTTCACGGAGAAGG CCGAGGCTGCAGCAGACCTCGATCGTGAAGTCCGAGTAGATGATACGCTCATCATACATGGCCTTATCGACCGCGTT CAAGGCCTTCAAGCGCGAGAGAATGCCGCCCGTCGTACGCCCGTGGATCAGAGCGAGGGAGCCAATGCTCAGGCCGT GACGCCAGCCTCGCATCATATCATTCTCTTCGCACTTGGTCCAGAGTGCTCCCTTGCGGAAGTCATTCATGCTGGCC AGATTCGACAGTTCCTTGACAGTACGCGGGTCCTTCCCTACCTTGCTATGCTTATCCATTTAAAGCTCCGGTTGTGT AAGTGAAAAAGCCAGATTAGATATTACTCTAATCTGGCTCTATGACACCCTGCGATTGTTAGATGAAGGGCGTGAGG TCTGCCTTGAAGTAGTGCGGGCCCTTCATGATCTTCTGCGTGTTGGGATCACGGACCGGCTTGTTGTCAACGAACTT CGACCAGTTCGAATCGTTGACCTCGTTGACGGCGCCCAGCATGTCGATCTTGTAGAGGACCCCGCTGCCGATGGCCG TGACGACTTGGTCGCAAAGCGAGTCAGCGAAGTCCAAGCGATCCTTGTCCATCACGACGACGGCGCCAGGGTCGGTC TTGCAGAGTTCGGCCAGATTGTGCAGCGCTTCACGTGCCTCCTTCAGCCGAAGACTCGCGAGGTGGCTCGTTCCGGT GAGGGATTCCACCATCTCAGCGACTTCTTCGAAGTGGCAGCCGATTTGCGTGGAGCGGTTGGTGCTGGTGGGGTTGG GAGTGGACTGGGTAAACCAGGCCGAAATCGATTTGTCCATTTGGACCTCAAAGTATGGAATGAGCGAGAACGGCGGT CTATAGAAAACCGCCATGGCCTTAGCAGCCCTTCATCAGCATGTCGACGACGGACTTGCGGCGCAGTTCCGGCAGGT CCTTGGCGGCACCCGACGGCGAGCCGCCAGCCTTCAGGATGCTGATCGCGCTGTCCTTGCCGAACTTGCCAGCGTGA GCACGCATGGCCAGTTGCACCTGGGTGATGTCGATCTTGGTGTCGTCGTCGTAGTAGTCGGGGAGGTCGCCGCTGCC CGTGTCTTCCGAGCCGCCAGAGTCTTCCGGGCCACCGAAGTCGTCATCACCATCGTCCGTGTCGTCCTTGAGCATGC CGGTCAGCAGCTCCATGACTTCACCGCTGACCTGCACGGTCTCGTCGCCGGCCTTGAGCAGCTTCAGGGCATCGTCC AGGTTGTTGATGGCCTTGGCTTGCGTTTCGGCGTCCATAGCCAGGGTCATGCCGACCTTGTCGCTGCCGGTCAGTGC CAGCACAGCTTGCGCCGCTGCCCGTCCGTCGCCGTTCTTGGCATTGACCAGTTCGACGATTTCGCCCATGCGCTTGG TGAAGTCTTCCTTCTCGAAGGGTGCCGGCTTGGTTTCTTCCTTCTTGGTCTCGGGCTTGTTGGCCTTGGCTTCTTGC TTGGTCGTGGTCGCAGCTTCTTGCTTGGCCGTGGCGGGGATCGCAATGCCGTTGGCCTTGAGGGCCGCAGTCAGTGC GTCGACGCTGCCGATGACGTCGCCCAGGATGGCGGCGAGCAAATCGACAGACTTGGTCAGCATCAGCGTGGACTGCG AGGATTCGGTGAGTTGTTGTTCCAGGGACATGAAAGTACTCCAGTTGGGTAAAAGGAAAGTGGTAAAGCAGACTAGA TCATAGCACTGTTCGAGCGTGGTTCGACGCCAGCTTTTATTCGCAGGATTTCAATGTTAAAGACTCGATTAAAATAG GCTTTTCGTCGACAACCCAAAAGGACTTGCAACATGGCGACCCTTGACAACTCGGTGCCTCGAAAGCCCGGGAAAGT TCCCACTCGTATGGTTTCGGTGCACGTATCCGAAGCCCTCATCCCCACGCTGCAGGGCGAGATTAAGCGCACTTACC CTGGCGGCATCAGCGGATTCATGAATGACGCATTGCGCGCGTACATAAAGAATAAGGAGCAGTAATGAAAGAGGCTC TCTGGCTAACAGAGGCTGGCTTCTCTCTTATCCCGCTCAATAGTAACCCAGCCGATCCGCATTATCGCAAACGCCCG CGGGACAAGGCGTGGCGAGCCACCAACTACCGTCTGGAGGACATCAAGAGCTCGTTCAATAACAACAAGGCCATCGG CGCTCGCGTGCCGCTCGGATACCTGGTTATTGACGTCGACGTGAAACCTGGTCAGAAAGGCCTGGAATCGCTTCAAA AGCTTCTCAATCAAGCAAGTATGGACCTGTCCGACTTGACTCAAGGTTCTTGGGTTAAGACCGGTTCGGGTGGCTTT CATTACTTCTTTGCTTTGCCGCCTGGTGTCGATAAGACCGGAGGCAAGGTTCCCGAACTGCCTGGTATCGACTTCCG CAGCAATGGCTATCAGGTCGTCGCCGCTGGTTCGATGAACGCTGCTGGCGGTATGTACGAATGGGATGAAACCACTC AGGCCTTTGAGGGTGTCACCATTCCCCGTATCGACACGGTAGCGGGAGGCCGTCTCTGGAAGTATCTCACCTCGCTG CGTGACTTCTTTGGCAGTGCTGGCCGTGAGAATGACAGTCGTGGCGTCAATACCCAGTTTTGGACTGACGCAGAGGT CCGGCGCATGCTGGAAGGCCTCGACGTGACTGAGTTCCGTGAGCACGAGCCTTGGTACAAGGTTATGTGCGCGTGCC ATGAAGCTTCCAACGGCCTCGCCATGGATGTCTTCCTGGAATGGTCCCACTCTGACCCTGACCCCAAGAATCACGTG GCCAAGGGCGAGCTCGAACGTCGCTGGAAGACTTTCCGTGTCAAGGAAGGTGGCATTACCCGGCGGTACCTCGAAAC CCTCAATGCCGATCGTGGTCGTGCCAATGTCGTCGCTCAGATGGATTTTGACACTCCGAGCATGCGACGTATGGGCG CTGCGACGCGCGTGGCTATTCGGGACGCAGAAGGCAATATTGACCTCGGTCCTAAGCTTTCGCAGCCCGTCGCCACG ATTAAGCGTGACGTCGTGGACCTGGACGATGAGCCGGACTTCCCCGAAGATGATGCTGACGTTGATATCCTCGATGC TGACAACCTGAAAGGCCCTCTGCAGTTCTTCAATGATGAATATGCGGTGGTTAATCTCGCCGGTAAGGTCGTCGTGG GTTCTCGCAAGATGAATGCCTTCGGCAACGAAGTCTGGGAGTTCATGAAGGTCAATGACTTCCGAGTGTGGAAAGCC GACATCAAGATGGAAGCCGTTATGGGCAATACCGTCAAGATCGTCCCCGCTTCTGACGAATGGCTGGAATGGCCAGG CCGCCGGAAGTACCACTCTGTTGACTTCTTTCCTGGTGTTCCTGGTGGTCGCGGTCTCAACCCAAAGAGCCACGCGG ACGGCGTTCTGAATCTCTGGACCTCATGGGGTGCGGACGTTTCGCTTTCGAATCTGTCGGCTGATGAATTGAACCGG CCGATCCCTCCCGAAAGCTGCTCGCAGTTCCACGAGCTTGTGCATAACGCGTTCGGGTCCGGTAATGGCGAGTACAC TCAGTACATTTATGACTGGCTGTGTTGGTCTATTGCCAATCCGGCACGTCCGGCCGAGGTGGCTCTCGTATTCCGAG GCGGCAAGGGTATTGGTAAGGGTTCTATCGCTCAGGTGATTGGGAAGATCGTCGGTGACTCGTTCTGGGCTACTGCCGATATGGACCATGTGATTGGTAACTTCAACGGCAACTTGAAGAGCTGCGCCTTCTTGTTCTTGGACGAAGCTCTCTG GGCTGGTTCGAAGCAGGCCGAGCGCAAGTTCAAGAACGTCCTGACCGAGCCGATCATCACCACGACGGATAAGGGAT TCCAACCGCTGCGCACGCGGAACTGCCTCCATGTTATCATGGCTTCCAACGAAGACTGGGTTGCTCCCGTCTCTGAG GACGAGCGCCGTTTTGGTGTGTTCGACGTCTTGCCCATCTATCAGCGCAACCATGACTTCTGGCATGCATTCCATCG GGATTACCTGGGGGACCACGGCGGAGCTGAAGTGGCCCGGCGCAAGCTCGCGGACCTTTTTGCCTGGATGTTGGCTC GCGGTAAGGCATTGACGCTTGCTGGATGGCGTCCTGCTAAGAGCGTTCCCCAGACTGAAGCCATGATTGAGCAGGCG GATTATTCACGCTCCGATCTTGCCTCCTGGTGGAATGAAGTGCACGATTCTGGTATGCTAGGAAGCGTGGACCTAAC CACCCTCGCGTCTCAAGCTCAGGACCTGGGGGAAGAGTTCGTGGTGATTTGGTCTCAATGGATTCGTGAGGCGATCA TGACCTCGGATTATGCTCCTAAGCCTCATAGGAACGCTGATCCGTACCACGTGGTTAAGAGGAAACTTGGCAAATTG GTTCAAGAAGCCTGGGGCACTAAGTTACTCAAGCTGACTGTTCCTAAGGAGCTAAGGGATGAGATTGAGCAAACCTC AAATAGGCAGGCCTATGGGTACTCAGTCCCTGTGTCAAAGCTAGCTTCATGGCTTAAAGTATAGCAGTTATAGCGAC TACCTGAGCATTTCAGCTGTAACCCAGTTAGCTCAGGTAGTCGATTTTTAACTGCATACGCTTATCTGCTATACTTT TTTTTCGTTTTTAAAAATACGACGTCATCCGAAAATAAAATACATGTTCATATGCACACAAATGCGCACTTCATGCA GCATGAACATGGACAATGTCCCAGACTGGGACTTTTTAAAATTCTTCGACTTAACTCAATTTATAGTAGATATAGTA GATATAGTAGATAAAAGTAAGAAAAAAGCAATAAAATCAGCGCTTTAAAAATATCCGCTAGAACTATCCGCTATGCT ATCTGCTAAAATTTGCCGAGAGGGCGTGGCTCATGAAGGCCTTGGCCATACATCTTCCTAAGCCTCCGAGCAGGGCG GCACCGCTCCTCAGAGGTTTGTTAACCGCAACCCAGTTCCACCTAGACGGACCATTCTATGTCACACGACCCAGGTA CACCCCAAGGACCATGACGGACCTACGGCACCCCTCGGACCTTGGTAAGCGGCTACAGGCGCCACAGGCGCTCGAGA ACTTGCAGTCCCTCATGTCCACAGCTATACGGCGTAGAAACCATGAGCAGCTTTGGTTCAAGATCAACATCGACATG AAGATACCGGCTGAGATTCGGAACTATGAGACCAAGATGCGCCAAGGTATCAATACCGTATTCACCGAGCACCTCTG GCCTGAATCGTGTGCAGTCATATTCCCCGAGAGCTTGCCGCTCATCATGCCGATGCTGAGCCGCATCTGGGTGCCGA AAGGCGTGCCGGTGGATCTGCCTGCCTGGGGTGTCTGGAAGCGATACGAGATGGTCGACTACGACGAACACTGTCGA CTTCGTTAATCATCGTGTCTGTCGTCGCAGCACGCTATCGTCTTCGAGCTTTCGAGTCGTCGACGATAGCGTATCAG TAGTAAGCCTCCGATCGCGTCTACGACCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCTCTATATTTGGTCCAG GTCCAGTCGGCCCAAAACTGGCCCGCTTTTCGGAGGTGGGTGGGGGAACATGTAACCAAACGTACGTGTAACCAAAT GCCACGCAACCAAATGTAACGGTTACACCTGGTTACATGGTTCACATTTGGTTACAATTTGGGCAATGAAAAGGGGC TCCCAAAGAGCCCCAGTTGTGTTAGGCCTTGCCCAGTTCCAGCGACGCCCTGTTGAAGTCAGGGGCTATGTACTTGA AGTCATAGAGATACTGGGCCAGTTCTGTGAGGCGGCGCGTCAGCCTGGTGTGCTTGGCCCTGGCCTCATCCTTCAGC GTGGGCAAGGGGGAGGGGCGATGCCTCTTCTCCTGCGCGTCCCAGACCATCTTGATTTTGTCCTCAGGCATGCGCTG GAGAACAGTCTTAGTGGTCATGAGCTGGGCTCGCACTTCCTGGTACTCGATCCAAACATCCTTGACCAGTCGCGGCA TGTTGGAGTAGGCATTGCACAGGCGCATTTTCGTGTAGGTCGACATGATGTCCTCTCGTTGTGAGTTGGTATGTAAA GATTATAGCCTAGAACTTGAGCTCAAACGTAACTTCAAGCGTCACACGTGTAACAACACGTACGGGCCAAACTGCGT TATAATATTGGCCTTTCTCCAGTAGCATTCAGTTACATGTTCGGCGCTTACTTTCCAGAAAACCTGTGTTAAAATCG CGCGCTGGAAAGCCGTAGTACTCTTTTACACTTTGGCCCGCTCCATTCCTCGATTTTCAGTCCTATAATATCTTTAC TGTCTGGCAACACAGACAGACAACAACTGGAGAATATCACATGTCGATCGAAACCCTCATCAATCAAGTTCAAGAAG CCCGTGACAACCTGGGCATGAAGCGACTGGCCAACCCCAAGAAGGTCGGCGCTGGCAAGCTGCAAGACATGCTCAAT GATCTGCGCATGAAGCTGGCCCTCGAGAAGCAAGCAGCCCCGGTGGCCCCCGAACAAGCAGAACCGGCCAACAAGTT TGAAGACCCGGTCTACTGGGAAGAGAAACTGGCCACTGCAGCAGCGATGCAGCAGCTCCCCGAAGAGAAGGTTGTGG TCAAGGAGCCGAAGGTCAAGAAAGAGCGTGGCGAGACTGTTAAGGACTACGCGTGCGCTCTGCTCTGCGAAGTGGTC GGCCAGCAAGACGGTCGCGACGTCGGAATGCCTTACGAGACTGTTCTCGAGCACATCCTCGTGAAGTTCCCCGAGGC TAAGACCTCCGTGAATTGCCTCCGCTGGTACGCTGGCAAGATCCGCATCGAGGCTCATGGCTACGTCGGCCTCAAGA TGCCGGCCATTCGACAGCGTGCTGTGAAGGCCAAGCCCGAACAGTCGCAGCCGGTGGCTCAAGAAGGCCAGGAATGA CAAAGCGGGAGGGGGAAACCCCTCCCTTCTTTTTTGCCTTTACCACCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCC GCTGCTGTATGGCCACGACAACTGGCCGAGTATGGTAGACCCATCTCGGCGTTCCGCGGTGTGAGAGACCAACATGT AACCAAATGCAAACGTCACTGATTGTAACGTGACAAGGTGTAACGGCAATGTGTAACAGGGCGCAACGAAGCGCCCT GTTACGAAGTACTACTAGGCGTTACGAAACGCCATCTTACGAAGCTTTTCAAAGTCATACGAATCGTAACAATCCAT TATTAGACCAAGTGACGAATTGTGACGAACGATTTGTAACACTTCGCTACTAGTCAACTTGTAATAAAACTTAGCTT GTTGCATATCGTAAGGAAACCTGCCACAATCTGAAACGAAAGGATCTGTTACAAATACGCCACTTTCTGCATCAGTA AAACCCATACCTTCTACTTCGATGGCGTTACCATTTGCATCATATCCTTCGCAACGATCTATTACGAGCTTCATGAC TGTACTCCCTGTTTGTTAAGTCAGTATGAATATTATAGTTGAGGCCCAATAAAAAGTACATAACTAAAGAGCAACGA GATGTAAAGGTCTAGTTACACTCTTTTACACTATTCCTATGTACATGCCTCTTATAAAGACCTATAATATTTATACT GACTAAACAACTGGAGCACATCATGATCAGGGTCATTAGCAACGTTACGTTTCGCATTGAGGAAGAGACCAATGTCA TCATGGCACTCACGCCCTGGGGCTGGCATCACGTGTCGGCGATCGATCATGATGCTGATAATGATATCGATTCTCAA CTGGAGGAAGCCGCAACAGACTTCATTCAAATGTGTGAATTCGTAACAAAGATGACTAACAACGAGGTGTAACGGCC CGTATCGACCTGTAACGGCCCCCTAGGGGCCTGTTACAATCGGTCACGCCGCGGCACCTCCATGCGAAAATTTTTTG CTACTTCAAGGCCTGGAGGTCCCAGTTGAGGTATGCCTATGAGCCCTTACAAAATTTTTTCCTAGGTTCCAAAGTGC CAAAGGTCCAAGCTAAGGAACTCTATCACTTTCGCTGGCTTACGATCCCTGTGTTTAGCGTCACAATCAGCCCAATCTACAATCATAGGCGGTGACCATGAGCTACACGTACGAAGATGAGGAAGAGGACACCCCTCAGCCTCAGCGAGAGCCA CCCAAGCAAGCCAATCAAACCAGTCAAACCAGTCAAACCAGTCAGCCCTTTGAGGACTCGTTCCTCTTGCGCCAACA GAAGGAACTGTTCCTCGATAACCTCGCACTAAATGGGAACGTCACGCTCGCCGCACGAGCTGCCGGATGGAAGTACC CGACAGTTGCTGAGCGCTACCGTGCCGAAGATGAACATTTCGCTGAGGCGTGGGTCGATGCGCTGACCCAGGCGACG GATGCGATGGAGTATGAAGCTCGGCGCCGGGCCATGGAAGGTTGGGATGAACCAGTCTGGTACATGGGCGAGCAAGT AGGGTCCGTGCGGAAGTACTCGGATCGTTTGCTTGAGATGATGTTGAAAGCTCATCGCCCGGGCCGCTTCCGCGAGG TTCAGCAGGCCGAGAACACTACTCCTGGCGTGCTGGTGATTACGCAGCCGCAAGGCCAAACTGCAGTCGAATGGGAA AAGCATGCTGCCCCGCAACAAAAACACCTCCTCGAACGGACGGTATAAGGAAGTCTGGAGGGCCCAAGAGGGCTCCC AGGAACTGTTCCTGTCCTCGCCCGTGCGTGAGACGCTGTATGCGGGAACGCGCGGTCCGGGTAAGACCGACGCTCTC CTCATGGATTTTGGCCAGCATGTCGGTCAAGGATTCGGAGCTGAGTGGCGAGGCATCCTCTTCCGGCAAACGCTGCC TCAGTTGGACGACGTCATCAAGAAGTCGCGTAAATGGTTCCCGCTGATTTGGCCTAAGGCCGTGTACAACAAGGTCG AGAAGCTGTGGACGTGGCCGACGGGGGAAACCCTGAAGTTCTCGTACATGAATGACCCAGAGGATTACTGGAACTAC CACGGCCACGCCTACCCATGGATTGGCTGGGAGGAACTGTGCAACTGGATCAATTCCGACTGCTACACCCGCATGAT GTCGTGCTGCCGATCGACCGAGCCCAATATCCCTCGGAAGATTCGAGCCACCACTAACCCTTACGGGCCGGGCCACA ACTGGGTTAAGAAGCGCTGGCATCTGCCGCACATGTTTGGCAAGATCGTGCGTGAAACCGATGAGGCCGGGAATCCG TTGCCTGAGCGCGTGGCTCTGCACGGTTCCATCTTGGAGAACAAGATTCTGCTCGCTGCGGACCCGGACTACATATC GAACCTTCGCGCAGCAGCCCGAAACCCGCAGGAACTGCGGGCTTGGCTGCATGGCGATTGGGAAATCGTTTCTGGTG GAGCCTTTGATGATGTATGGGATCCAAAAGTGCATGTCATTCCGCGCTTTAAAATTCCTGCTACTTGGCCTGTATAT CGCGCTTTTGACTGGGGCACTAGCCGTCCGTTCTCTGTCGGCTGGTGGGCAGTGGCAAACGGCGAGAACGTGGAGCT ACCCACCGGAGAAGTGTGGTGCCCTCCACGCGGGTCCCTTATCCGTATCGCCGAATGGTATGGCACGAAAGATATTG GAACCAATAAAGGTCTCCTCATGCCTGCTCGAGACGTTGCGAAGGGGATTATCAAGCGGGAGAAAGAGCTTCATATA GTCGGCTGGGTTCCTCGGCACTCTTTCATCCGTCCTGGTCCCGCTGACAATAGCATCCGATCGGTTGAACCTGGCAT GACCTCTACCGAGGACATCATGGCAGAGGAGAAGGTCAAGTGGGAAGAGTCGGACAAGTCTCCAGGCTCCCGCAAAG TCGGGTTGGAATTGGCGCGGCAACTCCTGTTTGATGCATTGCACCAGTCGCCCAACCCCGGCATGTATATTATGGAC AACTGCAATGCCTTCATTCAACTGTTACCCACCCTTCCGCGGGATGACGACGACCCCGATGATGTAAACTCCGACGC TGAAGATCACTTCTGGGATGAAACCCGGTACATGGTCCTCCGGTCGCGACGTCGCTACACCAAGATTGAAGCACACC ATCCATCACATTCTACTGCGAGCTAAAAATGCCACATGCAGCTACTACCGTATCAGTTGACCCGGCTCGCCGGCCGG AAATCAACATCCCCAAGGTCGACACGGTTCGCCCCGAGGTGACGGCCATGCTTCCCAAGTGGGAGCAGATGCGCGAC ATCCTCCAGGGCGAAGAGGCCATCAAGGCTCGCACTGTCAAGTATTTGCCAATGCCTGACAACGAGCAGGATCCGGA CCAAAACAAAAAGCGCTACGAGGCCTATGTGCAGCGGGCTGTCTTCGTGAACTTCACGGAGCGCACTCTTCTGGGGC TTCAAGGCCAGGTATTCGCTCA

[0095] SEQ ID NO: 17 (exemplary genomic sequence for phiACH04) TCATTGGCCTCTTGGACACGAGCATCAGCCTCTTGTTTGATGTGCTGGAGACTTTGGTCATAAATCTCCTGCATCTT GTTCTGTTCCACGATGGACTGTCCGGTCAGCATGCTGAGCGTCAAAGCGACACCTGCCATTGCCGAAACAATCATCA TGAGCCAGAAGTACAACCGCTCAAGAGTCCCGATGCGTCGGGTGCTGAACTTGCAAAGTGCCTCATTCATCTTGTTT GACATGGCTTTTCTCCACGAGGAGCTGATAGTACAGAGCGCGCCAGCGCTCAGTTTCCGCCTGAGATTCTTTTAGTT GGGCGATAAGGGCTTCGTTGGACTGGGTCAGGCGTTCCACGAACGAGCCATAGTTACCAATCACCGACAGGTTTCCA GACAAGTCTGCGCGTTGGGCTTGATCTTTAAGGGCCATACCTTGGATCAGCCGCACTGCCGCTGCTGCTACTCCTGC AGCAATCCCACCTCCGAATACCCATTGGAGAATCGTGCTATCCAAGGTATTCCTCTTTTAAGGTTGAACGTTGGCAA CTTTAACTGCATTTAGTGCTTAATTATATTGCGTGGGCGAAAACCGATCGGCCAGCAGTTACGCCATGCTGGTATAC GGCATCTGGGTCCAGATCTATAATGAATCCATGCTGTGAACGGAGAGCGCTATGAGATCCAAACAACGAAAGCTGGA GCTTATGAAGTGGCTGCCTGGCGTTTTCATTTACGATACCAACGCTCTTGGCGATACCCACGGCGTGAAGCTTGAAT ATTGCCGGATTGAGCAGATCAATGCGGTCATACTAACTGAAACCACACTGCGAGCAATGCTCGCTGAAGGGAGCAAG AAATGAGCAAGATCAATCTCAATCATCCGAACTGGTCTGGCAAGTCGTACCGTTCCTCGGATGAAGCTTTTGGCACG AGTAACCTCTACTTGACGCCGAAACAAGTCAACAAGTTCGGCCGGGAAAACCCGCTGACTTGGTTTCTGGGAGTTCT GCTCCTAATCTTGCTGGTGGCTCTGTGCTTCCTGCCCATTAACGCCAAAGCCTCGGAAATCGAGGAGATTGGAGGAA TCGACTATGTGCAACGTTCACTCGATAAGGTCATCGTCGTCACGCCCACCAAAACCTTTTCTCTCCCTGCCCCTCGC GGGTCTGGACAAACCTACGTACACGTCTCCGTTGAGCATGTCCGCGGGCGAAAACTGGATTATGGGCCTGGGTATCG CAACGATGCTTGCGCTCAATCTGGTACTTATTGCGGAAATATCCGGCCTATTGTAAAGGACCCGGAATGAACAAAGG GGAGCTTCGGCTCCCCTTCCTTTTACCCGTATCGAGCCACGTCAATGACGGTGAACGAGTAATTCTCTCGCCTTATG GACAAAAGGTTCCCAGGCGTGGCGCTAGGGCCAAAGTCTTGAACACATAGAGTTGTACCTATGGACTGATTTATCTG GGCAAACATCTGCCAAAAATAAAACTGCATGTACTGCACACCTGGCCCGACGCCGATCGGCACTTCTTCTTGGCTGC TACATGTAACTCCTTGTACTACTGCTGGTAATGTGCCTGGGTACGTTACAAAATTATAATTTGGTGTGCCGCCAGAT TGAGTAGTTGGCAGGCCAGTTAAAGTTCCGCTATCAAAGCCAGAGAACTTCATGTAGTCCATGCGGGAGTCATGCGT TATTTGGCCTAGATGATTTTTCAGCCGCATGGCGTAATTGCCGCCCATTAATGAGCCATAAACAGGCTCATCAAATAGGTACCAATAGACAGGCTCTCCAGAAGCTCCTGGGGTATACACCAAAAAGCTGAGTACTAGATTGCCTCCTGACGGA TAAATGCTCGCCAAAGTGCATGGTCGAGCGCATCTGAAACCTACCATTCCAACGGTAGGAGAAACAACAACTGTTGC AAACTTAAAGTTTACATGGATAGCTGCTTCAGTGGCGTAGGCAATGCCTCGAGCCCGAAGAGAGAAATTCTTATAGG TGCTGTCAAGCTGCACCTCGTTTACACCGTTTCGGGCTCGAAAGCCATAATCTGCCATTATCCTAATACTCCGTAAA CAATCCGGGCAGATATCCGCCACGCTGCGGCCCAGTTGAAAGTCCAACCGAGCGTGGTTCCGCTAATATAGACTTCA GGTGCCAAATGCGGTGTGGACAAAGAGCCGTTATCTGGTAGAAGTTGAAACATGGGCGTTCTACCAGCAAACTCAGG CACTATGATAGAACCTGGGTTTACGCCGGTAGCAACGACGCCAAGAATCCGAGGAATACGGTAGTTGTACTCCACCG AGATATTGCCATTGGCGTCTTTCGCCCTATAGCCGTAATAAGCCATTAGGGAATCCATCCAAAACGAGCGCGGTCAA TACCGTTGTTGTCATACACGGTGACAGATTGCGCGTCAATGACCAAACGGCCTCCACCTGGCAAAGCGTTATTGATT TCGAAGGTGCCATTCTTATGGAGACGCCACCCAGCTACACCAGCAACATAGTTGTTAGACTGAATGATGTCACCAAT CATCAAGTTGGTGATAGAACCGTTCTTGATGAAAGCGGTATCCATATACACGTTGCCTGCGTCAACGATAAACATGG ACTTAAAGGTACCAGTTACATCGTCAGATCGACCCACCGCAAAACGGTCGGCCAACACAAGCACTTGTGATTCTAGC ACACCTTGATTATTTTCGACACCAACACCAATACCTGCCAAAGCCGTACGACCGCCAGCAGTCAACTGCGTCTTGAC GGTATACATGGCTGCCAAAGCAGTTTCAATGGCCTCGATTTCAACGGCCGCTTCACCGCCGGAGTTGATCTTGGTCA GCAAGGACTGGGCCAATTGCGTCTCGGTAATCTTGCCATCGAGATACGCCATGATGATGTCAGCCTGATCGCTCGAC TGTCCCATCAGACCAACGCCGTTGTTATACCAAGGTCCAACGCGGCCTGCTTCGTCAATGACACGGAACCAGAAATA CCGACGGGCAGCCGGACCCAAGTCTGAAACCAAGAACTGGCTTGCAGGCAGGGGTAACTCGATCAGCTTGGTGGCAT TACCAAGAATATTGGTAGTACCCCAATAGATTTCAACTGACTCGGCCAGGAAGTCGTCTTCCCGCACAGCCCATTCC AGATTGATGGCAAAGACTTGGCCCGTGATATTAACATGGTCAATCTGGGACACAGGCAGTACAGAAGCCTCAATCGT GCCGACCCAAGTAGCCCAAGGACCGGTCAAACTGCCAATACCTCGAACTCGGACATACCAGAGGCCACCAGACAGAT TGACTTGCATCGAAGGAATCGAGGCAATGCCGAGATTGGACCAGCTGACTCCATCCTGGCTAATCTCAAACTCATAG CTATAGGCGCCACGAGCCGGCTTGGCCACGATATTTTGAACCCAAGCAAAAGGCGTAAGTTCGACGGTCACCGAGTC CACAATAGGCACGGTGATAATGCCAGGAAGACTCGACTCAGGGCCAGGAGGAGGTACGACGCCGCCGTTCTCAGCCG AGTGCACGCTATCAGCATAGTTCGTGAACGTCAGCTGCACTTTTCCGTCGCCATCCGGAGTAGCCGACAGCGCGATT GCGCGAATGCCACGGCGTTCGGTAGGACCGAACTGATACTGCGTAAGCTCTTCGCGCGAACCGTCCGAAATGTAGAT ATCGTCCAACTGGACGTCGGTGCCTTGAACCACGCACTTAAACGGATCCCCACTCGGATGCTCCACGACCGTGAAGG GGCCATGCGGCGAACCGTCACGGCGCTTGAAGACGATCGCGTGGTTCGATCCGGCTGCAAAGGTAAAAGGCTCGTTC GACGTCAATTCGCCACGCAGGCCCCATTCAGGATGATCTGGGCCAGGATTGAAACCCAAAACTTCACCCGAGAAGCC CCACTGCGGAACGTCATGAGAGATTTGAACCAAATCGCCATAACGAGGCAGATAACCTTCGCGGCCAGTCGTGAAGC TAATCATGCGCCGTTGGTCGCGGTTAGCCGCAGCCATGGACATGCCTTCACGCCAAGCTTGTGCCCGATTGGTGACA CCAATCATAGACACTTTGGACGGAACAGTAGGAGCCACCCCCGGCAGCACGCAGTCAACAGTTTCCTGTGACCAGGT CTCTGCATTGGTGTACTCGATCTGCACGTAATTGGGCGTGGAGGATGTGTCCACAAACAAGTAATCCGTGCTGAACG AGTTTTCCAGCATGTTTTGAGGCTGGAACATGTACGTGGGAACCGTTTTCGGCTCATTACGGACAAAGTCCACCAGG CCTGCGTAATTCACGGGCACGGTACGGCAAACACGAAGAACCTTGGAAAGCGCGTCCCAAAGTTGCGTCGTGCTGTC AAAGACCCCGTTGAACTCGTCACCACGGCTTGCCGCGACCTGTGAAAGGCGGTAGGCCTCTTGCACGTTGATGCGAG AAGTGGGCATGCGGCGCCCGTACGTGGAATTGCGCAGGATGTCACAAGCGGCCCACAAAGGATTCTTGGTAGGCACT GGATTCACGCTCCAGCCATTAACCGGGTCCCATACCGGTAGCTTACGAGTACCAATCACATTGATACGGCGCGAAGT TTGCTGGTTAAGGTTATTAGAGGCCTTCATGATAGTGGCCAGCAAGGTCACGTCACCATAGTTGCGCTGAGATTGGG CATAACCGCGCAGAGTAGACCAGTTAACCCGGTTCTGTTCTTTATTGTCTGGGTTGATACCCGTGTTACGCCAACCG CGAACATGGTACCGGCCCAAAGGTACTGCAATCTTTTCCGTCGCACTTTGAGGAGTGCTGGTGGAAAAGGTATAGTC CTTTTCAAACAACACATTCCAGGGACCGATGGCAGTTCCAGTGTCATCGATTTGCTGGTACTCAAAGCGCACGTTGA CAGTAGAAGCTGTGAAACGGCCACGGTCATCCATGAAGTACGCACCGCCGGGCCAGAACAAGTCCACGGCGATGAAA TTGGTCTGTACGCCAGGACCGCTTGCCGAAAAAGGCCCAAAAATCTGAGTAGGTTCCAATTCAAGCCCGTTGACTGC AATACTGGTTATAACGTTGTCAGGGAACAACGTGACAGCCTCACCAGGATTCACAATCTGGTATTGAATTTCACCAT AGGACGAGATATCATCATTCTCGACCATGATTTTTTCAACTTCCATCTGCCCTTGCGTAATGCAAAACAGCTGGTAC AAATACTGCTCGTTTCCAACAGTTTCCGAGTACGGCGAAGAAGCCAAGTCCGGGTAGGTACGGAATCGGCCGTACAA AACTGGAATGGCTTCAAGAAGTCGAGCGGTGTTGCCCTGGGCATTAAGGGAATAGGTAGGGCTTGCCGATTCCCGTG AGTAATCTAGCGCAGAGGGCGTTGGTGGAGGAAAGAACATGCTCAACAAGAGCGTACCACCAATCATGACAGCAGCA GAAGCTGCAGCACCCCAACCGGCACCCATTGCCAAACCGTTTGCGCCGCCTACCCAAGCGCCGGTGTACGCTGCGGC TACGGCCACAGCAATAATCATGATAGCTTGAAGTGGATTGCTACCACCCCCACCGCCTTTAGGCATGTGGATAATGG AGATATGATCGTCTTTGGTCACCCGCGTCGAAAATTGCTTTTCGAGCAGTGGCTGGCCATTGCGAACCACCAGGAAC GGCAACCGACGGGTCATGGTTTTACCACGGCCTTTGATATAATCCAGCTGACGGAGCAGGGTGCTGTAGCGAACACC CGCTCGTACCGGCTTCTGTTCGGTATCCGCCCCGCGGTGAAACGCGTTCTTATGCAGCAGGAGGGTTGCCATCGGTG ATATCCTTGTTTACGCGATAGTAGATAACTCGTCCGAAACCGAGTCCGCGCAGATTGCGGAGGGGTGTGGCCAAGAT GTTGTAGTCTTTCATGGCATGAAGAACAAGCCCGCCATCGATATCGAGAAAGACGCCGACGTGCGGATCAGAGCCGC CTTTCAGAAGGGCCGCATCGCCATGTTTCGGGGGATAGACAGGTTGCCAGATGCCATCTTGTACATGCCGGACGAAC ATCTCACGAAGAAGTTCTTCGTCGCCGAGAGAGGCTTCGGGAACGTCTTTATTGAAATACTCTTGCTGGATGTGGCGCATGAAGTTCCAGCAGTTGAATTTTTTGGGCCCTTCGCCTTCGAGGTCCCACTCATAGGTTCCGTCGAGGTAGCTGG TAACTTGTTCGGGTGTCATCGCTTCAGTCCTGGCCATTCATCTGGCATATACTTGCGGAAGGGGAAAGGCCAGTTGT GGACATCTTCCAGAGAGGCAGTGCCAGTAACCTGGAAGATATCGACCTTGACCTTTTTCAGTGTCAGGTGGATCGGT GGATCCATTTGTGGCGCTTCAGGCACCGTCGACAGATATGGACGATTGACGGCACCCAGCATGTCGATCTTGTAGAG GACCCCGCTGCCGATGGCCGTGACGACTTGATCGCAGAGCGAATCGGCGAAGTCCAAGCGATCCTTGTCCATCACGA CGACGGCGCCAGGGTCGGTCTTGCAGAGTTCGGCCAGATTGTGCAGCGCTTCACGTGCCTCCTTCAGCCGAAGACTC GCGAGGTGGCTCGTTCCGGTGAGGGATTCCACCATCTCAGCGACTTCTTCGAAGTGGCAGCCGATTTGCGTGGAGCG GTTGGTGCTGGTGGGATTGGGAGTGGACTGGGTAAACCAGGCCGAAATCGTTTTGTCCATTTGTACCTCGAAGTAGG GTATGAGAGCAAAAGGCGGTTTGTAGAAAACCGCCATGGCCTTAGCAGCCCTTCATCAGCATGTCGACGACGGACTT GCGGCGCAGTTCCGGCAGGTCCTTGGCCGCACCCGACGCCGAGCCGCCGGCCTTCAGGATCGAGATAGCGCTGTCCT TGCCGAACTTGCCAGCGTGAGCGCGCATGGCCAGTTGCACCTGGGTGATGTCGATCTTGGTGTCGTCGTCGTAGTAG TCGGGGAGGTCGCCGCTGCCCGTGTCTTCCGAGCCGCCAGAGTCTTCCGGGCCGCCGAAGTCGTCATCACCATCGTC CGTGTCGTCCTTGAGCATGCCGGTCAGCAGCTCCATGACTTCACCGCTGACCTGCACGGTCTCGTCGCCGGCCTTGA GCAGCTTCAGGGCATCGTCCAGGTTGTTGATGGCCTTGGCTTGCGTTTCGGCGTCCATCGCCAGGGTCATGCCGACC TTGTCGCTGCCGGTCAGTGCCAGCACAGCTTGCGCCGCTGCCCGTCCGTCGCCGTTCTTGGCATTGACCAGTTCGAC GATTTCGCCCATGCGCTTGGTGAAGTCTTCCTTCTCGAAGGGCGCCGGCTTGGTTTCTTCCTTCTTGGTCTCGGGCT TGTTGGCCTTGGCTTCTTGCTTGGTCGTGGTCGCAGCTTCTTGCTTGGCCGTGGCCGGAACCGCGATGCCGTTGGCC TTGAGGGCCGCAGTCAGTGCGTCGACGCTGCCGATGACGTCGCCCAGGATGGCTGCGAGCAAATCGACAGACTTGGT CAGCATCAGCGTGGACTGCGAGGATTCGGTGAGTTGTTGTTCCAGGGACATGAAAGTACTCCAGTTGGGTAAAAGGA AAGTGGTAAAGCAGACTAGATCATAGCGCTGTTCGAGCGTGGTTCGACGCCAGCTTTTATTCGCAGGATTTCAATGT TAAAGACTCGATTAAAATAGGCTTTTCGTCGACAACCCAAAAGGACTTGCAACATGGCGACCCTTGACAACTCGGTG CCTCGAAAGCCCGGGAAAGTTCCCACTCGTATGGTTTCGGTGCACGTGTCCGAAGCTCTCATTCCCACGCTGCAGGG CGAGATTAAGCGCACTTACCCTGGCGGCATCAGCGGATTCATGAATGACGCATTGCGCGCGTACATAAAGAATAAGG AGCAGTAATGAAAGAGGCTCTCTGGCTAACAGAGGCTGGCTTCTCTCTTATCCCGCTCAATAGTAACCCAGCCGATC CGCATTATCGCAAACGCCCGCGGGACAAGGCGTGGCGAGCCACCAACTACCGTCTGGAGGACATCAAGAGCTCGTTC AATAACAACAAGGCCATCGGCGCTCGTGTGCCGCTCGGGTACTTGGTTATTGACGTCGACGTGAAACCTGGCCAGAA AGGCCTGGAATCGCTTCAAAAGCTTCTCAATCAAGCAAGTATGGACCTGTCCGACTTGACTCAAGGTTCTTGGGTTA AGACCGGTTCGGGTGGCTTCCATTACTTCTTTGCTTTGCCGCCCGGTGTCGATAAGACCGGAGGCAAGGTTCCCGAA CTGCCCGGTATCGACTTCCGCAGCAACGGCTATCAGGTCGTCGCCGCTGGTTCGATGAACGCTGCTGGCGGTATGTA CGAATGGGATGAAACCACTCAGGCCTTTGAAGGCGTTACCATTCCCCGTATTGATACGGTGGCGGGAGGCCGTCTCT GGAAGTACCTCACCTCGCTGCGTGACTTCTTTGGCAGCGTTGGCCGTGAGAATGACAGTCGTGGTGTCAATACCCAG TTTTGGACTGATGCAGAGGTCCGGCGCATGCTGGAAGGCCTCGACGTGACTGAGTTCCGTGAGCACGAGCCTTGGTA CAAGGTTATGTGCGCGTGTCATGAAGCTTCCAATGGCCTCGCCATGGATGTCTTCCTGGAATGGTCCCACTCTGACC CTGATCCCAAGAATCACGTCGCTAAGGGCGAACTCGAACGTCGCTGGAAGACTTTCCGTGTCAAGGAAGGTGGCATT ACCCGGCGGTACCTCGAAACCCTCAATGCCGATCGTGGTCGTGCCAATGTCGTCGCTCAGATGGATTTTGACACTCC GAGCATGCGACGTATGGGTGCTGCGACGCGCGTGGCTATTCGGGACGCAGAAGGCAATATCGACCTCGGTCCTAAGC TTTCGCAGCCCGTCGCCACGATTAAGCGTGACGTCGTGGACCTGGACGATGAGCCGGACTTCCCCGAAGATGATGCT GACGTTGATATCCTCGACGCCGACAACCTGAAAGGTCCTCTGCAGTTCTTCAATGACGAGTACGCGGTGGTTAATCT CGCCGGTAAGGTCGTCGTGGGTTCTCGTAAGATGAATGCCTTCGGCAACGAAGTCTGGGAGTTCATGAAGGTCAATG ACTTCCGAGTGTGGAAAGCCGACATCAAGATGGAAGCCGTTATGGGCAATACCGTCAAGATCGTCCCCGCTTCTGAC GAATGGCTGGAATGGCCAGGTCGCCGGAAGTACCACTCTGTTGACTTCTTCCCTGGCGTTCCTGGCGGCCGTGGTCT CAACCCAAAGAGCCACGCGGATGGCGTTCTGAATCTCTGGACCTCATGGGGTGCGGACGTTTCGCTTTCGAATCTGT CGGCTGATGAATTGAACCGGCCGATCCCTCCCGAAAGCTGCTCGCAGTTCCACGAGCTTGTGCATAACGCGTTCGGG TCCGGTAATGGCGAGTACACTCAGTACATTTATGACTGGCTGTGCTGGTCTATTGCCAATCCGGCACGTCCGGCCGA GGTGGCTCTCGTATTCCGAGGCGGCAAGGGTATTGGTAAGGGTTCTATCGCTCAGGTGATTGGGAAGATCGTCGGTG ACTCGTTCTGGGCTACTGCCGATATGGACCACGTGATTGGTACCTTCAACGGCAACTTGAAGAGCTGCGCCTTCTTG TTCTTGGACGAAGCTCTCTGGGCTGGTTCGAAGCAGGCCGAGCGCAAGTTCAAGAACATCCTGACCGAGCCGATCAT CACCACGACGGATAAGGGATTCCAACCGCTGCGCACGCGGAACTGCCTCCATGTCATCATGGCTTCCAACGAAGACT GGGTTGCTCCTGTGTCGGAGGACGAGCGCCGTTTCGGGGTGTTCGACGTCTTGCCCATCTATCAGCGCAACCATGAC TTCTGGCACGCATTCCATCGGGATTACCTGGGAGACCACGGCGGAGCTGAAGTGGCCCGGCGCAAGCTCGCGGACCT TTTTGCCTGGATGTTGGCTCGCGGTAAGGCACTGACCCTTAGTGGATGGCGTCCTGCTAAGAGCGTTCCTCAAACTG ATGCCATGATTGAACAGGCTGATTACTCCCGCTCTGACTTGTCTACTTGGTGGAACGAGGTACGTGCTTCTGGTATG CTTGGCAGCATGGATATAGCCACCCTCGCGTCTCAAGCTCAGGACATGGGAGAAGAGTCTGTGGTGATTTGGTCTCA GTGGGTTCGAGACGCTTTGATGACCTCGGACTATGCCCCTAAGGCTGGTCGTGGGAGTGATCCGTATCACGTGGTTA AGAGGAAGCTTGGTAAGTTGGTTCAAGAATCTTGGAGGGTTAAGCCAGTTAAACTGACTGTTCCTAAAGACTTGAGG GACGAGATTGAGCACACCTCGAACAAACAGGCCTATGGGTACTTGATTTCAGCGACTGAGTTGGCTTCATGGTTTAA AATATAGCAGTTATAGCGACTACCTGAGCGTTTTAGCTGAGAACCAGCTAGCCCAGGTAGTCGATTTTTCTTCGAAGTACCGTCTTCCAGGACCAACGTGATAGCCATGCTTTACTCCTTGGGCGTATCCGCCGCCTTGGTCGACTTCTTGGCG GCCACCGGCGCTTTCAGCGTCTTGATTTCAGACTGGGCTGCTTCCAGCTCAGCTTTCAGTTCGCCGACGCGCTTGGT GGCACGTTCCTTGATGTCCGCGACTTCCTGCTCCAGCTCTTTGACTCGCGCCAAAGCGTTGTCGCGCTCGGTCTCGA TGGCACCGACGTCGAAGGTCTCGCCGAAGTCGTCGGTGGCTCCGACACCTTCAGCTTCTTGAGCCAGCCGCTTGTCA GTTTCGATCGAGTGCTTCAGCAGGTCGCTGAACTTGGGATTGCCCTTGGAAAGATCGAAGGGCTTGAGTTTTCCTCG CATGTCGGCTCCTTAAGCCGCGGCGCTGATGGTTCCGGGAGTCACGACTTCCAGACCAGTGCCAGGCTTGACGATGC CTTCAACGGTGGCCGTGGCCTTCGGCAGTTGCGCGGGCGTGGCAACGCCGCGAATCTTGTCGAAGGTCAGATTGCCG CCGGAAAAGACGGGACCGCCGGGAAACATCCCATTGGCGATGTCGATGGTGTCCTGCGCTTCCAGCAGGGTAGGGAG GCTCGGGTTGGTGCCGGGCCAGATCATGTCGGGCATGTCTTTCTCCTTTGCAGAAAAAGGCCCCGGAGCCGAAGCCC CGGGGTAAATCAGCCACCCAGCCGATTAACCGTTGGTGATGAGGAAGCTCATCGGCACCAGCTTGCGCTCGACGACG CGGTCCCAGTTGGCGGCCTTCTGCAGGTCGGCCAGGGTGGCCGACGGAGGCACGGCGCCATTGGGCTGCGGCGTGAT GGACGCGCTGGTGAAGCTGTGGCCCTTCGGATGCAGGATCCACGTCTTGCGCGTCCAGAGCGTTTCCATGCCGGCGC CGTTACCGGCACGGGCTTCGCGCTCGACTTCGGTCGGCATGTTGGGCGTGCCGTTGCCGTAACCGAACATGGCGCCG CCGAACAGGATAGACACGTACTTGAAGCCCGAGTCTTCGCCGGGGATCACCGGCAGCATGTCGTCCACGATCACACG GCGATCGAGGAAGTAGTGCACCTCGTCGGAGCCGCTGGACGGACGCACCGTGATGATGTCGTCGCTGTCGACCATGC GCTTCATGACCATGGAGTGCACGGCGATGGCACGCGTGTCCTTCCAGCGATCGCCCATCGTGAAGATGGCGCCGGAC AGAGCCTTGCGCGAGAACAGGTTGGCGTCCGTGGCGTTGTCGCCGTCTTCGATGGCGATGTTGTACACCATGTCGCC GCCGTCGTTGGCGATGTTGGCGTTCATGATGCCCAGGGACGAAGCGATCAGGCGGCGCTGCCATTGGCCCAGCCAGT ACTTGTCGACGCGGGCACGGATGCGGCGCATCGGATTCGAGCCGGCCAGTTCTTGCACCAGGTCCATGGCGGACCAG CCTTGGTTCATGAACGCCTTGCGGACGTCCCATTCCAGGGTGCCGATGGCCAGCGGAACGGCCAGTTGATTCGGGTC GTCGTTGCCGTAGTTGGGCTCTTCATTCAGGTCCAGGTCGCCCCAGGCCGGAATGGTGACTTTCGAGCCGCCTTGGT TGGCGTACGAATCGAACAGGTCCGAGTGGACCACGATGCCGGACTGGTAGAAGGTGTCCAGTTCAGCGGTGTTGACA GCCTGGTAGGAGTCGAAGACTTCCGGGATGACAACGTCGGAAAGACGAGTGGTTGGCATGTTGAAATGCTCCTGAAG GGTTTGTTAGATGCTGATGCCGTCGCTCTTCGCTTCAGCCGCGGCCCGTTTGAACCCTGCAGGGTCGCGGCGGAGCC ATTCCACGCGCTCCTCATCGGAGAGCTCGGAAAACTTCTTATCGCTGGCACCGCCGCGCTGTTGGCCCCCGCGGCTG CCGCCGCCAGAACCCTTGCCTGCAATTATAACGCTAGCGTACTCCTTTTTGCCAGCGATTTCCTTGCGCAGGTCTTC GATGGTCAACGCCGACAGATTGCCAGCGTCGTCGATCACCTTGGTCACGTGCTTGCCATCGACCTGTTCCACGCGAA GACGCTTCGCGATGACCGGAGCCAGGAGGTCAGGTGCCGTGCTGATTTCCGCGGCCATGCGTTGAGCCACGCCGGTG ACGAGCAGTTCGGTCAGGGACTGGTTCAGCGAGGCGATCGTGCCCTCGTATTCGGCCTTTTGCTTGTCGAACTTGGT GTTCCAGGACTTGTCCAGGGCGTCGACGTCGCCGTTCTTGCGGTGGGTGTCGTCGTTGCCCTTTTCGATCTTGGCCG TCAGTTCTTCGACCTTGGCCGTCAGTTCTTGCACGCGGCGCTCGGCGTTGGAACGATGCTCTTCGGCGATGCCCTTC TTCTGGGTCAGGTGGGTCACCTGTTCATCGCGGTCATCGTCGGCCAGCGACAGTTTGTAGCGGCCGTCCGCAGCTGC CTTGTAGAGGGCCTTTTGGCTGTCATCGAGGGCTTCGTATTCGGCCTTGCTGAGGTAGAATTTCATGGTCATTCGTC CTTGGGTTTGGTCTGGGTGGTGTTTTGAGATGGGTCTTCCGCTCCTTTACGCGGAACACCAATCTCCTTGCTGTCGT CAGGTTCGTAAGCAATGCCTGCCTTACGGAGCTGGCTACGGAGCTCGTTAGTGGTGATCGCGCCGGCCATCCACTCG TTGATGAGAACCTGACGTTCGTTTGGTTCCAACCGCGAGATAGCGAAGTCCGTCGAGATAACCAGCTTCAGGTCCTC AAGGTTGCCACCATGAAACTGGATGGCGTATTTGAGGCCCTTGAGGTACGCAGACTGCGTGTTCCGGACACAATTGA CCAGAACCGAAGCTTGCGTTGCCTCTTCGAGACGAATCGGCTGCGGAAGAGGCATGGCCAACCTCTTGGTACCACAT GAAGATCACCGCCAGGTGACAACTTAATTATAGTTTCAAGCTTTACTTCTTGAAGCCTGTATTTTGGTCGGAGTACT AGGATTCGAACCTAGGACCCTCTGCTCCCAAAGCAGATGCGCTGCCAGACTGCGCTACACTCCGAAAACCTGCGAAG CTCATAACATCGCAGGGTCAGCACACTTCATAGAGCCCAGGTGCATCGACGATCCAAGAAATCGCTGCACCACTATT CAGTAGCCAACTTACAGCGCCCTCGGTGAGAGGTCCCGCACGCACCAGCCCGGCCCGGGCTAAGATGAAGGCGCTGT AAGTTGGCGTCGGCCTAGAGAATCGAACTCTAGCGCTAGCAGGACCCGGGTTTAGACCTGTAGCCATATCCATGCCG ACAATTGTTGGAAGGGCTTTATTACTGGGAGCCCTTGCCTTCAACCCGGCCTCCTTTAAGTAGAGGCTAACTTCAGG CCAATTCCTATGCTTTCGCCGCCTTGCGGTTGACGCCGGTGGGGGCTGCGTAGCTCATAAGACTGGCCGAGACCTTA CTCGAAGTCGCTGCCCGGTTCGGCCGGACCGTCGAACTCCGCTTCGCCCATGCCAGCGAAGTCGCTGGCCGCATCGA CCTTGTTGTCCAGACGCTCGCCGCCGGCGATGAACTGGATGTTCTGCAGGCCGAAGGCGACGCCCTTGCCGACGTTG TCGTAGGCGTAGGCGGTCATGGTCACACGAGCGTAGCAGCCCGGGTAGAACAGTTCGCTGGAGGCTTGCAGGTCGAT CTTGCCAGTTTCCTGGTCAATGATCGGCTCGATCGGGTTGCCGTTGCGGTCGACGATGCCAGGACGATGCTTCGAGG AGAAGGTGATGAACTTCTTGCCCGGACCGAAGCCCGCGAGGTTCTCTTTCTCTTCGCCATCACGGATCGGCTTCTTG AAGTTCGCCGGCAGTGCCGACATTTTCTTCTTGAACTTGGCCATGGAGGCTTCATCGCCCAGCTTGACCATCTGTTC CCACAGAGCCTTCTCGTTGGCCGTGAACTTCTCGGGTTCAAAGATCAGCATCAAGCTGAACTTCGGAGCCGAGCCTT CATACGACGAAGCGGCGAAGACGGAGGGGAACGACACGCGGCCGACAGGGGTTGCGCATTTCACGATTGCCATAATA TCCTCATAAGTTTCATACTGATTGACTGCGCACGGTTTTGTGAAGCAGTGAAGAGATTATAGACGTACAGTTTTTGG GCTGTACGCCTACAGTTTACGCCGTGGCTCGGCCCGTGCCTTTTTCAGAGGCCAGCTTCTTGCGCAATTGTTCCTGC GAGAATGCAACCAAGCGGTTGTAAATCATCTCGCGCACGGCCGATTGGATCGTGTGCTGGTAGAACGAACGCCGACG GTTCGGTACCGTTTTGGCGTATTCCAGGACTTGCTTCAGCTCGCGTGCGCGGCGTTCATCTTTCCGTGACAACGTCATCGTAAAACTCCAGGGGTAAGGTTAATTGACGGGCCTTAAAATCAGCTTCAAGGGCCCGGTTGCGATACCACTCAAC CTCAGCGGCAGTGGCTCGATCTTGCCAGTCCAGAAGCTGCTGCTGCCCGGAACTCCAGTTAGCAGCGTGCTTCAGAC TTTTCCAGCGTGGATTCATTTCCGCTCCAAGCCTACGTCCATGATAACGACGCGGCGGGTCCAGACACGCGAATCCG TGCCAGTGATGGTCGTGAAGAACTCACGGCCTTTCAAGGGCACTGCAAGACGGTAGTCAGGGTTTTGACGGAGGAAC TCGTCTACTGAGCCCTTAAGGTTATGGGCCAGGATAACCGGGAACTTCACCGGCTGATCGCGACGGATATAGACAAG GGGAATATAAGCCTTCATGTTTGCTCCATGTTGTGTGACCAGGTTCTATTATACCTAGGAGCAAAATAAAAAGCCCA GCAGTTAAGCTGGGCTATGGCCTATATGATCTTGTACAGTCTGAATACATGCTCACGCAGCTTTGCCAATAAGGCCG GGCGTATGCCTTGCCCCTGCGTGATGATCCACCAGTACACGCTACGCCAGATCATCCAGATCGCGGGAAGCAAATAG ACGAGCTTCTTGAGGTCAGTATCCGCTGTAGCCGCATTAAGCCCATAGATATACTGCAGGACCTGGTAGCCAATGAC TGCCTCGCAAAAGAAGCCCACCATGACAGCGAGGTCTACGAGTATCTTGATGAAGTGCATGGTCACCAATGCCAGCT TAACACGAATCCAGCGGAACATGATTTACTCCCGGTCGAAGTCTACTTGGAGGTCAGAGAAGTCTGCGGCCACGTCA GTGGATACGTCCAGCTCTTGACGAGGGTCGGAGGTCGGCGCGATCGTCGGAGCACCTTCCGGCTTATAAACCAGCTG CTTCGGGGCCGTGTCCGGGTCTTGCAGCTCTTCGACAGTCGCGACGCGGTTGATATGCGCCTTCATCGCTTTCGAAA GCTTCTCGACCTTAGCCGGGCCCTTCATTTTGGGTGGTTCGAAGAGGTCCTCACGCTTGACGTCGGGGTCACCCTTG AGGATTTCCTCAACGAGTTCTTCTTCCGTCATGAAGTCCGACCACTTGCGGTTAGTCTTCTTGGCAACGACCTTCTG CCCAGGAATCTGCATCTGGCCAGTTAGGATCAGATGCTCAGCATGAGCCTTCACCCGCTTCACCCATGTATCGATCA TGGGTGCCCATTCTAGCGCGCGGGCGAATTGCTTGGGCGTGAGCGGCATGGGGAGGTCCGTTGGGGCCGTGACATCG CCTTCAGCGTTGGTGCCGGGTACTTCGATTGGGACCATCGCGAAGTCAACTCCTGCTTCTCGCTGGATTGCCTTCGC AGCCCACAGCCATCGACATGACTGTGACCTCCCTCCCCAGTCCTCGTAACAGAGGTACTTTTTAGGCTTGACCAGAG TAAAATCTAGTCAAGCCTTTTTTCTTTTGCGGAGCTAGAATTGAAAGTTCATACTGACCGAGCCACCGGCGACTTTG AAACGCGGTCTCGGGCCGACCTGCTCGTAGTTGGTGCCGACAAATACGCTCGAGACGAGAGCACGGAAGTCATATGC TTCTCATTCTTGCTGCCTGGTGAAGACCCGGACAAAGACGGAGTGCATGAGTGGTGGAATCCCTATGTAACTGGCTT TGATCTGCCGCCGGACAACGCCTATTACTTCAAACACCTGATGGCGTGGGTCAGAAAGGGCGGAAAGGTCGAGGCAC ATAACTGGGGCTTTGAATACGCCATTTGGAACAACGTCTGCGTGCCCGCTCTTGGTTGGGAACCGCTTCCCATTAGC CAAGGTATCTGCTCGGCTGCCAAGGGCTCTTACTACGCCCTGCCTCGGTCCCTGGAGAACATTGCTCAAGCACTGCA GATTCGAGACCAGCAAGGCAATTTGGTCGAGAAAGATATTGAAGGCTGGAAGCTCATGATGAAGCTTTCCCGTCCTG ACGGAAACGGCATGTTCGTCGGCACTGAGGGCGAGTTCCGCCGTCTCATCAAATACTGCTCGACTGACGTTCGGACT GAGCACTTCGTGTCTTGCGCTCTTCCGGATATCCCGAAGAAAGAGCAAGAGATTTGGGAACTCGACCAAGTCATTAA TACTCGTGGGCTTTACCTTGATCGGCCTATGGCTGAAGCTGCCCTGGCAATTGATGAGGAATTCTCTTCCAATCTGC GAGCAAAGCTTCCGGAGCTTACTGGTGGCATGGCGGATAAGCCCACGCAACGTGCGCGTATTAAGGCCTGGTGCGAA ACCCAGTCTCTCAAGCTGAAAGACACCAAAGGCACAACTGTTGACCGCGTTCTGGCTGACCCCAAAGTGTCGGACGT TGTCAAGCAAGTGCTCATCATCCTCCGAATGGGCAACCGCACGTCCACGGCCAAGTATCGTGCCATGCTTGATATGG TATGCGACGATAACCGCATGCGTGGCTCGATGATGTACCATGGTGCAACAACTGGACGATGGTCTGGTAAGGGTCTG CAGCCTCACAACTTCCCGCGGGGTGACATTAAAGGAACCACCGGCATCAAGGATATCGAAGAAGCCATGGAAGCGGC TCGCCGAGATATCCTCTACGGCCTGGAATGGCTGTCGATGGTCTATGACGACGTGGGCAAACTGTTGTCTGACGCCT TGCGTGGGGCCATTTGTGCTCCTCCGGGTAAGAAGCTGGTAGTATGTGACTTCGCGGCTATCGAAGGTCGTGTATTG CCTTGGTTGGCTAACGATCAAGAGCTGTTGGACGTGTTCCGCCGCGGGGACGACGTCTACTGCTTTATGGCGGATGC CATCTATGGCTACAAAACACACAAGAGTACTCATCCTGACGAGCGCTTCGTTGGTAAACAAGCAATTCTTGGCTTGG GCTTTGGCATGGGAGCAAAACGATTCCTTGCTGACCTCGCCGAGAAGTTCGATGTACACCTGCCGAAGAAGTTTATC GCCAACGTGGTTAAGGTTTACCGGACCGAACGTAAGCCAATTGTCAAGTTCTGGCGCGACATCGAGGAATGCGCCAT CGCCGCAGTGCAAACAGGTAAGCCGGTGGAGATGCCGGAAGGCAAGCTGACCTGGTACACGAAGAAGTATGAAGGCG TCGGCATTTTCCTGCACTGCAAACTGCCGTCCGGCCGATCGTTGTCGTACCCTTTCCCCTTGCTGCGAAAGGACGCC ACTTACTTCTTCGACGTTAAGCGAACAGTACAGACGCCAGAAGGCGATACCGTCAGCGAAACGGATTCGATTCGCAT TTCGGTGCCTAACGGAAAGGACTTAGCTGTCCGAGCTTTCCGAGAAGCTAAACGCATTGCCCAGCTCGAGGATGTAG AGCTGCTGGTAACGCTGCAGGACGTGGTAAATAAGGAGCCTTCGCTCAAGCTTACCCTCACTTTTATGGTCATGAAT GCCACGACCAAGCAGTGGGAGCGTACGAGCACTTATGGCGGGATGCTGACTGAAAACGTCACTCAGGCCGTGGCTCG AGACTGCATGGCTTGGTCTATGCTTCGTTTGGAGGCTTTTCCGTTTTATGAGCTAGTATTGAGTGTGCACGATGAAG CAGTAGGTGAGGCACCCCTCGATGATCCACGCGCATCGTACAAGCACATGGAAGAGGAAATGGCCCGCGGGGAAGAC TGGAGTGAAGGTCTGCCTATCGCGGTTGAAGGTTGGGAAGGCCGCATGTACAGGAAATAACATGGACTACAAAATCT TGTTGGAGAAGTATGTAAGCCACGTGCTCCAAATGGAAGGTACTACTTTCATAGGATGGCTTAATTCTGGGCGCCTT AGCGAAGTTGAGTTCACAGCAGAAGAAGCTGAAGAGCTGAGAAGGATTGGCACCGAGGTTGGAGACGACGATGCCTA TTAGAACGCTAGTGTGCATCAAAGGCCGTCCGGAAGTAGTTACAGAAGAAGTGGAAGCTAGATGACTTCACTTCAAA GTATACTGTACTGATGGGCGGCACAACAATTTTGGACCACGTCCGAGGGCATTATTCAGTCAACGGCCGGTGCTTCG AGCAATGTGAAGCTATCCAAATTGAGACTGATGCCCTAGACTACGGTTCGATATTCAAGAAAGCAGACGAGGCAATT CGCAATGGGACCATACGAACCCGTTTTTGAGCACTACAAGCACCAAGCGCGCGAGTTTGAGTTCCGCAATGAACCAT CCCGTGCGCTTCTATGGCAAATGCGGACTGGTAAGACAAAGGCCATGATTGACATGGCTTTTGCCCTTTTCGTGGAC GACAAAATTGACCAGGTGCTCGTGCTGGCGCCTAACGGCGTGCATCTCAATTGGCAAATCAAGCAGCTGCCTATGCACGCTTGGAAGTCAATGCCCTTTGAGGTTTGCTCCTGGGTATCCTCTGAGTCTCGCAAACCTTTGTACCTGCGAAAGC TGAATGACTTGGTGCTGAACCCAAAAGGAACAGCTAGGAACAGTCTGCGCTGGTACTGCATGAACTCTGAGAGCTGC TGGCGAGATAGGCCCAAGAAGTCCATCTCGATGTTCCTCGGTCAAGCCAAGAAAGGTACGCTCTTGATTGTGGACGA GAGCGATGACTTCCGCAAGATCAGCTCCAAGCGTACCAAGCTAGCTGTTCAATTGCGGGATCATGTACAGTACCGCC GGATTCTCACGGGCTCCTTCACTGACAATGCTCCACTGGCTGCCTATTCACAGCTGGAGATTCTGAAGAAGCATGCC TTAGGGTTTACCAAGTATTCTGACTTCGAGGCGCACTTCGCGACCTACAAGAACGCAGCTGTCTACGACCGTCAAGG CAATGCTCGGCGGGTGCGAGTCATTGACGAGTACCGGAATCAAACCGAATTGAAGCAGCTGGTGGCTCAATATGCCT CAGTCGTGCTGCGCGAGGAATGTGATGACATGCCGACGTTGGTGCGGGCTGATGAGTTCTTCGAGCTTGAGCCGGAA CAACGCAAGCTCTATACCAGCATATGCGATAAGCTCCTGGAAGAAGAAGGGCTGTATGGGGATATCTTCCTGACAGA CGTCTTCTCTGGTGGGGTCAAATCCATCAAGCTGCAGCAAGTCTCCAACGGCTTCTTCGTTGACGCAGAAGGGGAAG TAACAGACCTCCCGAACCCGCGGGCAGAAGTCTACCGTCGAATTATCCAGGAGCAGTTGTTGGATGGTAGAAAGGTT ATTACCTGGTGCAGGTACCACGAAGATATCAAGCGCGTCAAGAAGGTACTCGATGAGCTTGGCATTAAGTACGTAGA GTTCCACGGCGGAATATCGACGCCTCAGCGCATGAAGAATATGCACCGCTTCATGACTGATGACGAGTACACTGTCT TCATTGGCCAACCTGCCGCAGGTGGACGAGGTCTTGACCTCTCAGTGGCCAAGACTGTTATATGGTATAGCCACACC TACGATCTGATCCACCGGCGTCAGGCGGACGAACGTGCAACCCATATCGGTGGGCATACAATCGACGTCATCGATTT GCAGGCTGTAGACACTGTGGACATGTCTATAATGAACTCACTGTCTGAGAAGACTTCCCTCTCAGACTATGTAAGCC GGCACGGACTGCAGGCGTTTCTCACAGGGAAAACGCTGGTTTAAGCGCCGAGCAGATGAAGTTAATATCTAGTTACA CCATCTTTGAATCACCACCCAGTCACTTTTCTAAGGACACGATCATGACCGAAGCCAGCAAGCCCGAAGACACCAAG ACCGAAAAAGCCCCGAAGGCTCCCGTCCACAACATCAGCACCGTCGCCCGTGAAGCCATCCGTGCCGGCCTGTCGAA CGCCGACGCCCTGGCCAAAGTGAAGGCCGAATTCCCCGACGCCAACACCACGGTCCAGTCGATCGCCTGGTACCGCA ACGACCTCCGCAAGAAGGGCGAAAACTACCCGTCGCCGGAACGCCCCAAGGTCGAAAAGGCGCCGAAGGAAAAGAAG GCCAAGGCCAAGAAGGACGACCCCAAGCAAGAACTGCAAGCGGCCGCCACCGGTGACAAGGCCGGCGCCGACGCGAA CGCCGAGTTCGAATAAGCCTTTACGTCAGCCTGCGTCAACGGCCAAAAAGCCCCGAGTTCTTCGGGGCTTTTTCTAT TCCTGTTCCTGTTACACAGCATTGGTTGTTATCTACCGAGAACTCGGCTATAATATCTTTAATGACTGAACAACTTG GAGCACTGAAATGACTGTCCCCTCGTACGAACTCATCAAGGATAACATCGGCTGGGCTCGCGTGTACTGGGCGCGTG GCGACCTGGAGTCGAAGTCGGCACGCATCAACGAGGTGCAGAATCCGCCCACGATTGGCTGGAGCCATGTTATCATC ATGGACAACCCCAAACAATGCACGATCTTCTGCCCGTTCACCTTTCAGACCTACCAGGTCTCGAAGCGCTCGGCCGA ATGGCCATGGAAGCGCTGAAGCGTCAAGAAGAGGCGCCGATGATCTACATGGAGAAGTTCCCGCTCGCAGCTATCGA AGCGGAACCGGACGACTTCGTGGCACATTATCAAGTCGCGGACAGTCGTGCTGTCCATCCATCTTACGTCTGCCGTC CGGAGGTGATAGCATGAGCCGTGTTATTGGTGCTCTTGACTGGGGCTCGATGAACATCAAGCCCGAACAAACGTCCC AGTACAAATGGGATAAGCGCTTCATCCAAATGGCTCACCTGGTGAAAGGCTGGTCCAAGGACGAGCGGAAGGTCGGT GCCGTGATCGTGCAAGACCGCAAAATCATCGGCATGGGCTACAACGGCTTTCCGTCCAAGGTGCTTGACCAGCCGGA TCGGTACGCGTCCAAAGACGTGAAGCGCGGGCTCATCATCCATGCTGAACTCAACGCCATCTTCGACGTCGAGACCA AGATGCTGCTGGAAGACGCCACGCTTTACGCCACGCGTTTTCCGTGCAACGAGTGCATGAAGGCCCTCAGCCAAGTG TGCATTGGCCGCATCGTCAGTCCGCCGCCGGAAGTAGATCATCCGGTCTGGGGCGAAAGCCATAAGTTCTCGCTGCT CATGATGCATGAGAGCGGCATCACGTTCACGGAGATGAGCTGATGGCAGCAAGCCCAAAGATTGCCGAAACGAACTT GTGGCGTTGGGTTCGTGAGGCTAAGGCACACTTTGGGCGCGAACTCCACATTCAGCGGATCGAGAGCTCTACGGGGC TCGGGATTCCTGATGTGGAGGCGTGCCTCAAAATTTGGCCTAGCAGTTTCTCATTCTGGATTGAGCTCAAAGCGGTG GCTCGACCAGCTCGTAGCTCCACGCCCATCAAGCACAATATCACCGCTGAACAAATAGCATGGCACAGGAACCGCTA TCATGCCGGCGGCACCTCGTACGTGCTACTGCAGATAGGCTCTGGCCGTGAAAGCAAAAAATACCTCATCCCTGGCA GCGAACTCCTGGCCTTTCAAAAACCCATCACTGAAGAAGAAATCCGATTCTGCTCGCGTGAAGCGACGGACTGGACG CCACAAAGATTGCTGGATGCGTGCGCGCGTCCTGAAACCTAAAAGGACCCTTGACATGAAATTCGTTACCCACAACT GGATCGGCAAACGTCGGGTCCTTTCGTTTGACACCCCTGCGACCCACCGGAAGTTCATGGAGCGCTATGGCTACTTG GGCGGGCTCCAGGAAATCACAAATGGTGAGGCCCTCAGCATCGTCATTGCTGAGGGCCAACCGGCAGACGCCCGTGC GGACTTCCGCTCCCACCTTCACATCACGGCTACAGCTTTTGAAGCCCTGCCCGGTAGCCAAGACCAGACTTCCACGT AAGAACTTCTTGACGTGGCAGACTGCCACCGGCCCGCAGCCCCAGGTGAACCCAGGGGTTTCGCGGGCCGATTTCGT ATATGAGCTGGTCGAACTTTATGCCCGACGCCTGGATAGCCTTACAAATTTCGTAAGGAGTTCCAAAGAGCGGGCAG ACGAAATCGGCGGCGAGGCCGAGACGATGGGCGGAGTCTGGTACACCGCCGACAGCTTTGTTGAGAGCTTCACCCCG GAAGCCTGACGAGATGATGACCGGTTTGCCGCCGAGGACATTACGGACCTCTTCCAGAGTCTGCGCCAGGCGCAAAA GGTTAGCCTTCTCAGCTTCGGTAGGAACGTTCTTGATTCCACGCGCGACTGCAGTGTCCGAGTGGATCAATTCCTCC AAAGTGAAGTGCGGGGTAAGGTTCATTTCGATTCCTCTACGATGTTGGCCCATCCTCTGGTTTCACGGATGGTGCTG GTGTATCGGTCAGCATCTCCTGCCACCTCTCGATATCGCTCGAGAACCTCTCGTAGTACCATCCAGACGGAGGAAGG TCCACGTACAGAGATGCCGGCGGACTTGGCGAGCGCGGCGGCGCCAGCGGCTTCGGTTGCGATGGACTCTTGCAGCC GGAAATACCGGCTATCAGCAGCAATACGAGCAAGGCGCGCATTTTCACGTTCCTGTGCGAGGGTCTTTTGGACCTCA TTCCATTTACGGTTCCAGTCTGCTTCTTTGACCCGATTGGCCTCAGACTGGTCTAGGGTGGCCTTAGTCTGCTCAGC TTGGGCTTTATCATAGCCTCTTTGCTCTGCGGCACTGATCCGCCACGTGTAGAGCCACGCGGCGAGACCAATAACAA CTAAGGTCACTAGGACGTAGACCTTAGGGCTTAATTTCAATCTTGGCTCCTCGCACCGCCGAGGTGACTACACTCGGTGGCAGACGGTCTATGATGGCCTTGAAAACTGGGTGAAGACTTCAACTACACCCTCAACGTGAACTTCTTCGACGCT CTGCCTCCTCTGGCGGCTGAGCTCTACGAAGGCGAATAACACCTTTCAACCCACCCAGCTGATTAGGAGCTTTACAT GAAAACCAACCCTTACGCCCAGTTTGCTTCCGACACCAACGCGGAGAAGGAAGGCATCTGGATCAACTATGACCTGT TCCGTGTGCTTCTGGCGCGCGCCGGTGGCTCGAACGCCGCGTACCTGAAGGCAGCAGACCGCAAGCACCGCGCCATG CGTCGTCAAGGTTCGCAGGGTGTCATCGCTCTGCAGCGTCTGGCCCGTGAGCTGCTGGTCGAAGCGTGCATTAAGGA CTGGCAAGTTCGCGCCGAAGACGGCACGTTCCTGCCGAACACGATCCAACTGCCTGACGGCTCCATCGTTCCCTTCA ACAAGGAAAACCTGGAAGCCGTCATTCACGCTATGCCGAACCTGGCAGACGCCCTGAACGCCGAGGCCAACAACGAA CAGTTGTACCTGGCCGAAGAACTGCAGGAAGAAGCGGGAAACTGATCGAAGTCCTGGTCTACGGCGTAGAACAGGAT GAAGAGCAGATTGAGTTCATACGGCAGCAGTGCCTGCAACAAGGGCGACCTCTTCCAGCCCGAATTGCAAACGCCCC TGAACTCAAACCCGGCCTAGAACTTTACTGGTACGCCTTTCAGCGTCTCAGCAGTGGTAGACCAGTTGGCTTAGGCC CTGGAGCAATCTCCTGGATTCAAATCGAGGAGTATTGCGACAGGGTCGGGTTGTACGGGGAAGAGCGGGATATCATG CACCACCATATCCAGAAAATGGATAAAGAATACTTGAAGGCCGTTAAAGCAAAGGCCGCCAAGAATCGAGGTAAAAG CAATGACCCGCCCGTCAACAAGCGTTAGCTTTACCAACTTCAGTAAACGGATGCGCTCGCTAGGGCAGTCTGTGGAA CACAACTCGCGAGAGGGTGTGAAGCGGATTGCCCGAGCCACCGTGATAGAACTCATCAATCGGACACCTGTTGATAC AGGACAGGCAGCGTCCAATTGGCAAGTGGGATTAGGATCCTTTCCAGCTGGTCCTAAGTTCGGGTTCACGGATATTC CCGCCGCTCGTGCACTCGCCCTGGCCATGATTGAACAAAGACAGGCAGGCCAAAATGTCTACATCTCCAACCTCCTC CCGTACATTGGCCGGCTGAACGCCGGATACTCTGCTCAGGCGCCGGTTGGATTTGTGGAGAACGCTCTTGTCCAAGC TAGGGCAATTGCGCGAAACATAAGGCTCCTTGAAGATGGCCGAAGAACTTCACGTTGAGGTTACCGAGCGCGGAGCG CGCGAGGTAAGCCGAAATATCTCTGATATCGGCGTTGCGGCGACCGGTGCTCTCAATCCTCTGCGAAACCTTGAGCG CTTGCTCGCAGGCTTCGTTTCGCTCCAAGCTCTGCAATCACTGAGCAAGACCCTCGACACTTACACCGAGATGCAAA ACCGTCTCAAGACCCTGGTAGGAGCCACCGGCGACTACAACGGGGCCTTGCAGCGCTTGGCAAACATCTCGGCAAAC ACCCGTTCCTCGTTGAAAGACAACGTGCTCCTGTTCCAACGAATGGGTTTGGCACAAAACGAGTTGAACGCGTCGAC TAATGAGCTGTACAAGGTGTCCGAAACTGTCGCACAAGCCATTGCCATTCAAGGCGGCTCGGCGGCTACGACGTCGG GCGCAGTTCTTCAATTGTCCCAGGCATTTGGCTCCGGACGCGTACAACTGGAAGAATTCAACTCGGTTATCACGGGT TTGTACCCAGTTGCCCAAGCGGCTGCCAAAGGTATTGATGCAGCGGGTGGTTCGATCGCCAAGCTGCGGCGCCTTAT TGCTGATGGCCAAATCAACTCGCGTGACCTCTTCCAGGGTATCCTGAAAGGCGGCCAAGACATTCAAAAGCAGTTTG AGCAAACTGTTCCTACTGTTTCTCAAGCTTTCCAAGTGTTGCGTGACCGTGTGCTGGTATACGTAGGCACTTTGAAT GATGCCATTGACGGGTCTGAGACCTTTGCTCGCTATGTGCTGGCCTTGTCCACCAATCTGGAAAGTCTCGCTAAGGG CGTGACTGTCTTGGCTGTTGCTTTGGGCCCTGCAGCTTTGGCAGGCTCCTTGGCTTTGGCCAACTCTCTGCTTGCGC GCATGAGCCTCATCATCATGGCGCACCCGCTTCTTGCTCTCGCTTCGTTGATCGCCGGCCTCTGGGCAAGCACTTGC TCGAGAAGTGGGCCACGTGGACTAAGCTCGGCATGCGTCGTGACTTCGGCATGGCTGCGATCGTACTGCGCGCTTTC GGCATCGAGGCGCCTGTCACGGAACTGTCGGCAGGCCTGGAATATGATGACTTCGGCGATCCTATCGAGCCGGCTAT TGAGAGCAACCGTAAGGGCAAACAGTCCGAAGAGGAGCTGAAGAAGCCGGTCAAAAGAACCTCGAAGCGCGGTGAAG TTCTCGCGTGGTTCTTGGAGGACGGAGGCGGGCCCAAGTCGGTGCACGCGGCTATGGCCGTGTTCAAGACCACTCGC TCCAACATTCTGAGCCACCTCTTTATTCTTCAAAAAGATCACGGTATTGGCTATTCCCTTGCCAGCAATACCGCTAC TGTCTTTGTCCCTGGCAAGGTCGATCCGTTCCTTAAGGAAGAAGCATGAAAATCCGCCGGCTTAAGAACCGAGTTAT TCCTTGGCATCTTCGTCGTAGTATGTATAAGGAACTGTCTTCGTACATCATCAAAATAAAGCGGCGTCAGCGCATCC AAAAAGTGAATAGCCGCTTTGAAAAATTTGCAACCAAGAAAGGAGCTTGAAAGTGAACCAAACCAAATACGCCGTTT TGCCGGAAGGCCCCACCAGCATCAGTCTCATGCTGGCACAAAGCATGACCAACCAATTCAACCTCAACATCTTGCAG GTTCCGTCCGGCACGCACGAGGTTTCGGTGATCGATGGCGAGGCGCAAGTCAAGATCATGACGCCGCGACTGCTCGG CGAATCCCGTATGGCGGCTCGTATCGAGCACCTTTCTGAAGAGCTGCTCGAGCTGAACGAAGCGTATGAAAAACGCG ACATGGGCGAAACGGTTGATGGGCTCATCGACCTCATCTATATCGCCATCAGTACCCTGTCCGAGATGCATGTAAAT GCTTCGCGGGTGTTTTCGGCCGTGCATGAGGCTAATATGCTGAAAGTGAACGGCACTGTCGCAAAGCGCCCGAACGC CGGCAATCACGATGCAGTCAAACCCGAGGGCTGGAAAGCTCCCGACATCAACAAAGCCATCTACGGAGAATGATACA TGGCCCGCCGATCCAATCTGCAAATCTACATCGACAACGTGGCAATAGCGGCCAAGCGCAAGCTGACTGCGGCTGAG AAAGCCAAGCTGGTCAAAGCCTACAACGCAGGAGACGGTCGAGTGTCGGCAGACACGGCCTCTGAAATCATCCACAA GGGCAAGCCGTCTGTCGGTCAGCGTGCGGCTTACGACGATCTGAACAAGCAAGCGCAGAAGCAGTCGTCCGAAGAGC TCGTGGACAGCCGATCGGCGCTGTACGGCACGTTCTGCGGTCGTGCTGACCTGACTGTCGACCTCATGGAGCGGTTG CAGAAGCACCCCAAGTGGCCGTCCATTCCGTCGTGGGGCAAATGGGCTCTCACCATGCTCGTCGAGAAGATCGGCCG CATCGTTGAGGGTGATCCGTCCTATGACGACAACTGGAAAGACATCGGCGGCTACGCCGAGCTGGCCCGTCGCAATT CCGTTGGGGAAAAGGCATGAGCAACTTCGCCAAGCAGTACCGCCACATCATCAAGGGCATGCTCGACGGTACCAATA TCGTCGAGCAGCATAACGAGCGCACGGGTGAAGTCGTGCGCACGATGCCTGGTGGCCTCTCTTGGGGCTTCTGGATC GCCAATCGTATGGCGCCGACCATAGACCTCCGCCGCACCTACATCAAGACGGCAGCGGCCGAGTGCGCGTGGTTCGC TCAAGGCACCCAAGACACCTCCTGGATCAAGAAGCATTGCTCTATCTGGGAGAAGTTCGAAGAGCCTGTGGCCTTTG ACTTCAATGGCAACAAGCTCATTGGCGTCAAGAACGCTTATGGCTACCGCTACCGCAACCACTTCGGCCGCGATCAG CTCCAGGATGCCATCAACGCTCTGCAAATGGACCCGAGCAGCCGCCAGATTTACATCTCGGCATGGGACCCGGCTCG CGATGGACTGTTGACGCGTGGCGAGAAGAATGTGCCTTGCCCGGCGGCCTTCACCCTCAACATCATCAACGGCCAGCTGCACTCGTCTTATTTCCTGCGTTCCTCGGACTTGTTCGTCGGCTTGCCCTACGACATGCTGACCCACGCGCTTCTG GTGACTGCCATGGCAGACTCCTTGGGCATTCAGCCGGGGTATATCTCTGTGCTGGTCGGCCATGCTCACATGTACAA GAAGCATCAAGAACAGTTGAATGAAGGCGTTGCAGTTGTCCATGACGTACATGCCGGGATTAGGCGACTGGTGCAGC GCATCAAACAGGAGTTGCCGCGCCAGTTCCAACCCGACTTTGCGGGAACCTGGAGATTTGTCCGACTCTTCCCACTT GACCTTCTCCTCCGCCATGATGTCCTCGGTAGAGGTCATGCCGGGTTCAACCGATCGGATGCTATTGTCAGCGGGAC CAGGACGGATGAAAGAGTGCCGGGGAACCCAGCCGACTATATGAAGCTCTTTCTCCCGCTTGATAATCCCCTTCGCA ACGTCTCGAGCGGGCATGAGGAGACCTTTATTGGTGCCAAGATCTTTCGTGCCATACCATTCGGCGATACGGATAAG GGACCCGCGTGGAGGGCACCACACTTCTCCGGTGGGTAGCTCCACGTTCTCGCCGTTTGCCACTGCCCACCAGCCGA CAGAGAACGGACGGCTAGTGCCCCAGTCAAAAGCGCGATATACAGGCCAAGTAGCAGGAATTTTAAAGCGCGGAATG ACATGCACTTTTGGATCCCATACATCATCAAATGCTCCACCAGAAACGATTTCCCAATCGCCATGCAGCCAAGCACG CAGTTCCTGCGGGTTTCGGGCTGCTGCGCGAAGGTTCGATATGTAGTCCGGGTCCGCAGCGAGCAGAATCTTGTTCT CCAAGATGGAACCGTGCAGAGCCACGCGCTCAGGCAACGGATTACCTTGTTCATCGGTTTCACGCACGATCTTGCCA AACATGTGCGGCAGATGCCAGCGCTTCTTAACCCAGTTGTGGCCCGGCCCGTAAGGGTTAGTGGTGGCTCGAATCTT CCGAGGGATATTGGGCTCGGTCGATCGGCAGCACGACATCATGCGGGTGTAGCAGTCGGAATTGATCCAGTTGCACA GTTCCTCCCAGCCAATCCATGGGTAGGCGTGGCCGTGGTAGTTCCAGTAATCCTCTGGGTCGTTCATGTACGAGAAC TTCAGGGTTTCCCCCGTCGGCCATGTCCACAGCTTCTCGACCTTGTTGTACACAGCCTTAGGCCAAATCAGCGGGAA CCATTTCCTCGACTTCTTGATGACGTCATCGAGCTGAGGCAGCGTTTGCCGGAAAAGGATGCCTCGCCACTCAGCTC CGAATCCCTGACCGACATGCTGGCCGAAGTCCATGAGAAGAGCGTCGGTCTTACCCGGACCGCGTGTACCCGCATAC AGCGTCTCACGCACGGGCGAGGACAGGAACAGTTCCTGGGAGCCCTCTTGGGCCCTCCAGACTTCCTTATACCGTCC GTTCGAGGAGGTGTTTTTGTTGCGGGGCAGCATGCTTTTCCCATTCAACTGCAGTTTGGCCTTGCGGCTGCGTAATC ACCAGCACGCCAGGAGTAGTGTTCTCGGCCTGCTGAACCTCGCGGAAGCGGCCCGGGCGATGAGCTTTCAACATCAT CTCAAGCAACCGATCCGAGTACTTCCGCACGGACCCTACTTGCTCGCCCATGTACCAGACTGGTTCATCCCAACCTT CCATGGCCCGGCGCCGAGCTTCATACTCCATCGCATCCGTCGCCTGGGTCAGCGCATCGAGCCACGCCTCAGCGAAA TGTTCGTCTTCGGCACGGTAGCGCTCAGCAACTGTCGGGTACTTCCATCCGGCAGCTCGTGCGGCGAGCGTGACGTT CCCATTTAGTGCGAGGTTATCGAGGAACAGTTCCTTCTGTTGGCGCAAGAGGAACGAGTCCTCAAAGGGCTGACTGG TTTGACTGGTTTGATTGGCTTGCTTGGGTGGCTCTCGCTGAGGCTGAGGGGTGTCCTCTTCCTCATCTTCGTACGTG TAGCTCATGGTCACCGCCTATGATTGTAGATTGGGCTGATTGTGACGCTAAACACAGGGATCGTAAGCCAGCGAAAG TGATAGAGTTCCTTAGCTTGGACCTTTGGCACTTTGGAACCTAGGAAAAAATTTTGTAAGGGCTCATAGGCATACCT CAACTGGGACCTCCAGGCCTTGAAGTAGCAAAAAATTTTCGCATGGAGGTGCCGCGGCGTGACCGATTGTAACAGGC CCCTAGGGGGCCGTTACAGGTCGATACGGGCCGTTACGCTTCGTTGAGTTCGTCCAGTTTCGCTATGCGGAGTTCAA AAAGGAAACGCCCGGACTAGCCGGGCGGGGTTGAAGCTTAGGCTTGACGCCCGTGGATCGGTTTGGTCTTGAAGGCC GGCGCATGGTTGAGGATGCTGACCACAGTGACCGGTGTCACGCCGTCAGCTGTCAGCACCGTGGCCTTGTCACCGAC CTTGAGAGGCTCGGTCGAGTGGTAGGTGTAGCGCTTCTTGCTGGAGGCGAAGACGACCTCGACAAAGTAGACGTGGC CCATGTCAGTTGCGCTCCTCAGCGTCCGGGAACAACGGCGGCATGCCCGGGATATGGCCGAAGGCGCCGGCGATCTT TTCCATGACTTCCTTCAGCTCCGGGTGCTCCTTGACCATCTTGGCCATGCGCTCACGGGACTTCTGGGCCAGTTCTT CGATGTGCTCGGCGATGACTTGCTCGTTGGACTTGCTGGACAGCATGTTGCGAGCCGTCTTGACCTCGTCCGATTCG CCCAGATCACCCAGCAGCGCGGCCAGTTGTTCCTGGCGCGACTTTTCGGTGATGGACTTGCGGAGGTTTTCACGCGC TTCGTCTTCGCGGGCGACCAGGGCGTCGTAGTTCGAGCGGTCGAACACCTGGGCCAGCCACTTGTACTTGATGCCCT TCTGCAGGTCGGTGACGTGGGCGAAGTCTTCGACCACGACCAGAGCCGGATGGCCCGCCGGGGTTATGACGACCGCG ACGTCATTGACTTCGAGGTCACCACGGTGCTTGTACGTGTACTGCTTGCCCGAGAGCACGCCGTCCGTCATGAAGCG GCAGACCGGGTAGACGACGCCTTCTTCCAGCAGGTTGATGGCGTTTTGGATTTTTTCTTGCATTTCTTGCTCCTGGT TGATTTGAGTGTCTGCGTGTTTGTCAACGCATTGAGAAGATTTTACTGCCTGGGCCTCGATATGAAACCCTGCGTTC TTTGCTGCTTTGAGGAAGGCTTCATCCTTCAGCATGGCCTGTGCGAAGCTGGCATCAAACGCATGATCCAGGTCACC CATGGCCACGCGCAGATTGCCTTCACGGTCATACTGGCGCACGTTGCTGCCTATGTAGACCATGACGTCCTTGGTCT TCTTGGACCGGTCAATGGGCTTGTCTACTTGCTCAGTGGTCGTGATATGGCCTTCAGCGTCGCGGTAGATGAGGGTC GGCCATTTCAATCCCTGCAAGCCTTCTACACGGGTCTTGATGGAATAGCACGCATCAAGCTGGCCAGCATCACCAGC GAGTTCCTTTGCCCGTTCCAGGTCACGGTTTTCAACCCACGTACGAGCAATGCGGACATCATAAGTTGGCATATTGC CATTATGCGTCATCTTGCCTTGGCGCATATAGGTCTGTTGAGCCGAGAGCGACAATGCCTGCGGGTAGTAGAACTCC AATGGAGTGTGGTCGCACTTCTCGTTGGAGATGGTGGAGTAGGGCTTATAGCCCATGTACGCACCAGCCTGCGGCCA CTTCATGGAATCAGACAGCATTATCCGCCGTTCATTGCCAGGGAAGAGTACAGTAACTTGGAGGCCAGGAAAGCGTT CCGTCATTTCACGGAGAAGGCCGAGGCTGCAGCAGACCTCGATCGTGAAGTCCGAGTAGATGATACGCTCATCATAC ATGGCCTTATCGACCGCGTTCAAGGCCTTCAAGCGCGAGAGAATGCCGCCCGTCGTACGCCCGTGGATCAGAGCGAG GGAGCCAATGCTCAGGCCGTGACGCCAGCCTCGCATCATATCATTCTCTTCGCACTTGGTCCAGAGTGCTCCCTTGC GGAAGTCATTCATGCTGGCCAGATTCGACAGTTCCTTGACAGTACGCGGGTCCTTCCCTACCTTGCTATGCTTATCC ATTTAAAGCTCCGGTTGTGTAAGTGAAAAAGCCAGATTAGATATTACTCTAATCTGGCTCTATGACACCCTGCGATT GTTAGATGAAGGGCGTGAGGTCTGCCTTGAAGTAGTGCGGGCCCTACAGTTCATGCTGCCGGCGCCTACGCGTCGGC CGTTGTCCTATTACCCAGCTTTTCCTGCTTCTCTGCCAGAACCTGAGAAGGACTCCTACGAATATGGGGCTCCTGACCGGATGCTTATTGACCGGGATGAGCTGGGTGGCGGCAAGCAAGATGGCCGCAAACGGTTCTCGAGTGTCCGCACCGA ATACCGCGTTAAGTGGCTGCTCGATAACGAGCAGAAGGCTACTTTTGACGCGTTCCTGAGCGCAGATATTGCAGACG GTCTTGCGTATTTCAAGGCGCCGTTTGCTAACGGCCTGGGCCCCACTCAATTGCGAGCACGCTTTACCAAGCCGCCG GTGGCTCAGCCTGAAGGAGCCCTTGCTTGGGTTATTACTGCCAGCTTAGAGACATCGGAAGCGCCAGTCATCTCCTC CTATGACTATATCTACCGCGATGGCCTCGTTGTTACTGAAGGTTTGACCTTCAGCGAACAGACGATTTTCAATGTCT TTTATGGTCAAGCTTTTGAAGAAGCTTTCCGGTATGCTGAGACGGTGTCTTTTAGCCTGACACAGCAGGTTCCGGAA ACCATTATTTTCTCTGAGGATGTTAGTTTAACGGCGACGTACGTTAAAATACTTGAAGAACAGCTGGTATTTGGTGA ATCCGGCTTCATCTCCACGGCTGACTACGTGGACGACACATACTTCGCAGAATCCTATGTCGGGTATTCTGTTTCCT TCTAAGGTACCATCATGTTGAAATCCGGCCTCATCTGGACTGGCGAAGTCTACTTCGAACTCAATGGCGAGCTGTTC TATAAACAGAACATGATCGTGGACGCGGGTTTGAGCTTTGCTTCAGACTCCATCTTCTTGCCTGCTACTACCGGCAA GCTGTCCTTTATTGGCCTCGGCTCTGGCACTACCAATCCAGCTGCCGGCCAAACGGCTCTTGTCACCCCGATTCCTC TTGCTTCGGGCGGTACGGTCTTCCGCAAGGCTTTCGATGCTGCTCCGACGCGTGCAGGAGCTGTCACGACTGTCAAC ACCACGTTTGCGCCTGGTGAAGCCACCGGCAACGTCAATGAGGCAGGCCTGTTCACGGCTGTATCGGGTGGCGTCAT GTTCTCCCGTGTGAAGACCACGGTCACGATCCCCAAAGACGAAAACGCCGAATTGCGCGTGCGGTGGGTCTTGACGG CCTCGCGTGCCGCCTAAGGAGTAGGATATGCCCGCAAAGACTATGGTATTGCGGGCTGCTAAAGGCAGCCCGCTCAC CAATCCCGAAATGGACGCGAACTTGCAGTCAGTTCTTGACTACATGAACGCCCAACTTTTGCCAACGACGGCTCACC ATCTCGATAACTATGATACGCCTGGAAACTGGTACCAGGGAACGGGGGGCTCTGCTACTGTAGAGCAAGGTTATCCG ATCGCTGGTGGCACTGGCTTTTTGCGTGTCAACACCTTTAACTCTGCTACGTGGCAAGAATACGCGGTCCGTACTTC CCCCTTCCGCTCGTATTATCGCATGAAGACGAGCAGCGGCTGGGGAGGTTGGCGGCAAAACATTCAGATTGGAGACG GTGAACAAATTCCGCAGCCGTATATCCCGCCGCTTTATACCAGTACGATTTTTGCCGGTACTAACGCCAATACGGTG ACCGCCCCGGGGAGCTACGCCATCCAGTCGGACGCGGATGCTACGGCCGCTAACAACTGGCCTACGCTCTGACCGCG GTTTTTCTCGAGCAGAAGCTTTAGCGGAGCAAGCGGTCAAGGTCTACGAGGGCAAGGCAGGAGCCGGTGGTATCTGG TTCCGCAATGTTCGATCTGTCGAGGTTGGTGCTGCAGACGGTTGGCACCAGTTCAACGCAATTGCGGAATTTGACTA CTCAATCAAGAGGTAACTCATGGCTACCTGCCAAGTACGAAAGATCGACTCCAACATTGTTGGCCTGCGCATCGCTC AAGAGGAGTGCTTGAAGCAACTCCCGCAAGCGGTGGGCGACATTGTGTGGAATCCCCTGGAACCGAACGGCTACCAG GACTTCGGTGTGCAGACCTCGATGGTCGCGCGCAATCCCATCAACCCGTCGCGTCAACGCCAAAAGGGCATCGTCAC CGACCTGGAAGCGTCCGTCGGCTTTGGCCTCGATTTTGTCTACGCTGAGCAGAAGCGCCTGTTGCCGGGCATGATGT TCGCTGAGATCCACCAGCCTGTCGCTGCGATGGTCGCAGTCACCGACGCTGAAGTCACGATCGTCGGCGGCATGATG CGCCTTGAAAGCGCAGACCTGGCGGCCATCGTCTCTGAAATCCGCACTGGTGACTGGCTGTTCATCGGCGACGCAAA TGGCCGCTTCGTGGCGGACGGCAACTGCGGCTTCAAGCGCGTGCGCTCGATCGAAGCCGGGGCCTTGGTGTTTGACA AGGGCATCGAAAACGCTGAAGCTGAAGACTTCACGGGCGAACTGTCCGTGTATCTGCCGGCAACGCTGCGTAACGAG TCGGGCGCCGACATCGTTCGCTCCTCGTACCAATTCGAACGCACGCTCGGCTCGCTGGACGGTCTCGATCCGCCTCA GGCGGAGTATGTCAAGGGCGCTGTGCCGAGCACGTACGCCCTGAATATGCCCACGGCGGACAAGATCACGACCGACT TCACGTACACGGCCTGCGACGGCGAACTGACCACGCAAGCTGATGGCCTGAAGCCGGGCACTCGTCCGACGCTTCCC GACGCCGATGCCTACAACACATCGACGGACCTGAAGCGGGTGGTTATGTCCCGCGTCCATACGGGTACGGTGGCTCC CGAGCCTCTGTTCGGTTTCCTGCTGGAATCCACGCTGAACATCAACAACAACCTGACTGGCAACAAGGCTCTCGGTG TCGTCGGCAACTTCGACATCACGGCCGGCACGTTCGAAGTGAGCATCTCTGCCACGGCGTACTTCTCCGATGTGACC GCGATCCGCGCGGTGCATGAGAACGCGGACGTTACGCTTGACTACCTTCTGATGAAGAACAATCAAGCTGTGCTGTT CGATCTGCCGATGTGGGCTCAAGAACCGCAATCGCCGCTTCCAAGTGCTTCGTGATTTCACGAGACACATTGGAAAT GGTAATCTGGATTTCAGGTATGGCATTTTCTTCCATACGCGGCAGCACCAGACTGAAGCGGCAGGCCATGAACTTGA CCATCTGTCCGCCATTGAGCGGCGCATCAGCTTCGAGTCCAAGAGTTTGGTCTTCGTAGCCTTGAACCACCCGGATC GCAGTCGGCTCCCCAAACTCGTCCACGAATTCAGAGTGGCGAAGCTCGAGGGTGTCAAGAGGCACCTCGTCCACAGG AGACGAGGCATATGCCTCTTTCATTGCTTGTTCCCAGCTCATGCGTTCCCCGCTTTCAGTGCCTGAATTTCTTGCTT GAGTTGCTCAATTTCTTCCTGCTGGGCTTGTACAGCGAGGATCAAGTCTGGTACCAGCTTGGAATAATCTACACCTT GAGGCAGAATTTGAGATTCGAAGCCCGGCATTTCCATCATGGCGTCTTTTTCGCCACTGACCGCGTTCGGGTGGGTC GTCGCCAGCTCATGCGCGAGAACACCACGATCTACCTTTCCATCTGCCTTCCAGGTGTAGTCGTGGATTACAACCTG CATAATCCGCTGCTGGCCGGCCTGTTTATCTGCGTAGCCAGTGAGGTTTTTCAAGCGGTAGTCGGATGACGTATTGT AAACAGTGGCGCCTGCTGAAGTTGTGATGCTCCCAACCAAACCGCCCGCAGAATTCTGAAAAGCCAAGGCCGCGCCG TCGTTAGCGCGCGGGCACATCAGCATGCCCCATTGTACCGCTCCACCTGCATAGGTAACGCGCACATTGGCATTGGC AGCAGCCGCTGTCGGAGGCTGGCCCAACTCCCAGTTACCGGTTCGACCAATCCAGCCGCAAAGTCCAGCATCACTTT GAATAACAATTTGAGCTGGGGCTGTTCCGGTTCCATGCTTACTGAACAAAAGTCGGGCGACACCATTGGCAGTATCG TTGCCAATCATGAAGAAGCTTTCGTTTCCAGATTCTCCACCTCGGCACAAAAAAGCAGAAGTACCACCAGCAGCAGA CGGCACTGCTTGCACGTACGTGTTGGGCGAACTCAAAGTCCCCTTGAAACGAACGGACGTAGCGCTGTAAATACCGT CCATATTGCCAGCAATGGTTGCCCCCGTGCCGGTGCCCGTCAAATTCAGCGTAACTCCGTTCCACAAGCCCAGCGCC ACTTCTTGCCATGTGCCCCAGGTGTTGGGTGCTGGTGAATCAAACCGCACCCGCACAAACTGGCGAACAAACCCGCC ACTACCTCGAGTCGTGTGGGGGAACATGTAACCAAATGTACATGTAACCAGATGCCACGTAACCAGATGTAACGGTT ACACCTGGTTACATGGCTCACAATTGGTTACAATTTGCTCGCAAAAAAGGGGCTCCCAAAGAGCCCCAGTTGTGTTAGGCCTTGCCCAGTTCCAGCGACGCCCTGTTGAAGTCAGGGGCTATGTACTTGAAGTCATAGAGATACTGGGCCAGTT CTGTGAGGCGGCGCGTCAGCCTCGTGTGCTTGGCCCGTGCCTCATCCTTCAGCGTGGGCAAGGGGGAGGGGCGATGC CTCTTCTCCTGCGCGTCCCAGACCATCTTGATCTTGTCCTCAGGCATGCGCTGGAGAACAGTCTTAGTGGTCATGAG CTGGGCTCGCACTTCCTGGTATTCGATCCAAACATCCTTGACCAGTCGCGGCATGTTGGAGTAGGCATTGCACAGGC GCATTTTCGTGTAGGTCGACATGATGTCCTCTCGTTGTGAGTTGGTATGTAAAGATTATAGCCTAGAACTTGAGCTC AAACGTAACTTCAAGCGTCACACGTGTAACGACACGTACGGGCCAAACTGCGTTATAATATTGGCCTTTCTCCAGTA GCATTCAGTTACATGTTCGGCGCTTACTTTCCAGAAAACCTGCGTTAAAATCGCGTGCCCGCATCGCGCGCTTTATA TAGGGCCCTTTCGTAGTACTCTTTTGCACTTTGGCCCGCTCCAGTCCTCAATTTCTCGTCCTATAATATCTTTACTG ACTAACCAACTGGAGCACAGTCATGAAGAGCGAGTATATCAAAAGGATTGAGCGCGCAGTGACAGTCGCTGTATACA AAGCGCTGGAAGCTGAAGTTACAAAGCTCGAGGCTGAAGACCCCAATCTCGATATGAGTGTTGATCTTGAAGACTTC GTGGTGTCGCATTTTGGCCCCGATGAAGTACTGAAAGTGATTATCACCCACGAAAGTATGTAGTACTCTTTTACACT TTAGGGGGCTCACAGCTCCCGCCCAATCCACTATAATATCTTTACTGCTTGAGAACAAGCAGACAACAACTGGAGAA TATCACATGTCGATCGAAACCCTCATCAATCAAGTTCAAGAAGCCCGCGACAACCTGGGCATGAAGCGACTGGCCAA CCCTAAGAAGGTCGGCTCTGGCACCTGGCGTATGCAGAAGGGATGGGGTTCGAAATCGCCACTCCAGCCGACGTGGT GCCTGCTCTGCTCAAAGGTTCTCAGTACCTGGACTTGGTTCCTCGTGCTGAGTACCAGGGCTCCAAGACTGTTGCGA CGCAGGCCATGCAATGGCCTCGTCGCGGCGTCACTATCGATTGCGTGGCATTCCTCGACAATGCTATTCCCAGGGAA TTGAAGGTAGCTCAAATGGAGCTTGCCCTTATCGCCCTGCAAGATGACTTTCTCGAGCTCTTCAAGAACTCGGATGG TTATCCGGTCTACCGAGTTAAGGTGGACGTGATCGAAGAGCAGTATATGACACCCCGTCAGCTGTCAACCCGGCCCG ACGGTTCCATACAACAGCCGCAGTACCCCAAAGTCGACGCGCTCCTGTTCCCACTTCTGAAGGGCAACGAATGCCCA GGAGGAGGAAGCTCGGGTTGGGCGCATCTGCGGGTTCTGAGGATGTGATATGGCCATCAGGCTCCACCGGCTCGCTT GGGCCGAACGCACGGCGCTCCGGCTCATCAAAGAGTACGGAGCGCCTTGTCGTATGACTATCGACTTTCCTGGGCAG CCTATTCCTGGCCAACCTGGACGCGTCGGCCCCAGTCTTCAAGAGACTGTCAATTTCAGCGGGGTGGTTCTCTCCAA CCTGACTGACATTCAAATCCCGTCAAATGTCGTCTTCTCTGACGTGCTTATGGCTGCTTCGAGTGAGTTTCGGCCGT CAGTAGCTATGCCTTCCCCTCCGACGGAGTATCTCCTTGGTGCTGCGACGTCCATTTTCAAAGAGGGGCAATGGAAA GAGCTGCGGGTGAAGCACGTTCAGCAAGTTGTCCCCAACGGGAACAGCATTATTTTCCGCTTTTTCCTGGGGGCATA AATGCCAATCACATCTACCGCTGAAGCCCGTGACATCATGAACAACATGGCGTACTCGGGCATTACGGCCGGACAAA TTCAGTTCGTTGGTGACGAGAAGCTGACGGCCCCTCAAGGCAATATTGACTGGTGCCGTGTGCAAATCACGCACGTG CTGGGCAATCAGGAAACACTGGCTAATTTCAATGGCGTTCGTCGATATAATCGTACGGGTACGATCATTGTACAATG CTGACATGTACATGCTACAAACGACGCACTTCGTGCGGCATGAACATGAACATGGAAATGCCCCAACTGGGACATTT TTTCGGGTTGAACTTCAATTTTTATTGACTATATTGACTATAGTAGTTAAAAGATAAGAAAAAAGCAATAAAATCAA TCACTTATCTCTAGTCAATAGGACTTAGCCGCTATATAGTCGCTATAAAAACCCGAGAGAGCGTGGATCATGAAGGC CCTCGCAGTACATACACCCAAGCCTCCGAGCCGAGCAGCACCGCTTCTCAGAGGCATGCTAACAGCAACCCAGTTCC ATATAGACGGACCATTCTATGTCACACGACCCAAGTACACCCCAAGGACCATGACGGACCTACGGCACCCTTCGGAG CTCGGTATGCGGCTACAGGCGCCAGAAGCTCTCGAGAAACTCCAGAGCCTTGTCTCAACGGCTGGAAGGCGAGAAGA TCGAGAGCAGCTATGGTTCAAGCTCAATATAGACCCAAAGATACCAGCTCAAATCAGGGATCATGAAACAAAGCTCA AACGGGGTATATACTCTCTGTTCTCGGACCACAGTTGGCCAGAATCATGTGCGGTCGTATTCCCAGATAGCTTATAC CTCATTCTGCCAGTCGTGAGCCGCATCTGGGTACCGAAAGGCGTGCCGGTGGATCTGCCTGGTTGGGGTGTCTGGAA GCGGTACGAGATGGTCGACTACGACGAACACTGTCGACTTCGTTAATCATCGTGTCTGTCGTCTCATTACGCTATCG TCTTCGAGCTTTCGAATCGTCGACGATAGCGTATCAGTAGTAAGCCGCCGATCGCGTCTGCGACCGCCGCCGCCGCC GCCGCCGCCGCCGCCGCCGCCTCTATAGTTTTGGTCCTGGTCCAGTCGGCCCGAAACTGGCCCGCTTTTCGGAGGTG GGTGGGGGAACATGTAACCAAATGTACATGTAACCAGATGCCACGTAACCAGATGTAACGGTTACACCTGGTTACAT GGC

[0096] SEQ ID NO: 18 (exemplary genomic sequence for phiACH05) GAGGATGCCATCGCGGCCAAGGACGCTGTGGACGCCACCGTCGATACGGTCAGCGGCTACGCGGCCGACGCGCTGGC CAGCAAGAACGCGGCAGCAGCCAGCGCGACCGCCGCAGCCACGAGCAAGGACGATGCTGCGGCCAGTGCGACCGCCG CAGCCGACAGCGCCACGGCATCCGCCACGAGTGCGACCAACGCCAGCACGAGTGCGACGGCGGCGGGCAACAGCGCC ACGGCGGCCAACACCAGCAAGAACGCGGCGGCCAGCAGCGCCACGGCTGCGGCGGGGAGCGCCACGGCGGCCAGCAC GAGTGCGGGTGACGCCGCGCAGAGCGCGACCGATGCCCTGAACTCGGCCACGGCCGCAGCGAACTCGCGCAACAACG CCCAATCGGCGGCGTTCACGGCTGGGGATGCCGCTTCCCAGGCCCAGCAGTTCCGCTCCGAGGCCCAGACCTTCGCC TCCCAGGCGCAGCAGTCCGACAGCAACGCGCTCAACAGCATGATCGCGGCATCGGGCTACGCCAACCAGGCCCAGAC CTCGGCCACCAATGCCGGCACGAACGCGACCAACGCAGCAGGCAGCGCCAGCGCAGCGGCCGACAGCGCGACGGCAG CGGCCAACAGCGCCACGGCTGCGGCGGGCAGCGCCAGCGCAGCGGCCGACAGCGCGACGGCAGCGGCCAACAGCGCC GCTGAAGCGGCCGACTCGGCTTCGGGCTGGGTGGCCGGGGTTGCCCAATACGGGTTCCCCCAGGCCAAGAACCTCAC GGGCACCGTGGACTGGCAGACGCTGGACACCTCGGGCATCTATCTGCTGCCCAGCCTGGGCACCAATGGCCCGCCGG TCTCCTATACGGGAACCGTGATCGCTCGGGTGGAAGCGGCCGACAACGGCGTGCGCACCGTGACGGCGTTCTTGAACGCCATCAACAGCACGCTGCCTGTGCAGACCTGGGTGGCCACGCGCACGGTTGACGGAACGTGGCGGCGCTGGGAAGC CACGAGTGGCTATGGCTACCGCAGCGTGACCACGGCCTCGGGCAACCGGACCGTCTCGGTCGATGAACGCGGCACGC TGATCTCGGTCACTCCCACGAACGCGCCGGTCTTGACGCTGCCGGCGCTCGCCGACACCCAGGTGTCCGACACCTTC TCGTTCTACAACAACTTCACCGGCAACGTGATCACCATACAGGCCAACGGAAGCGACATGATCGGCGTGATGCCTGA TGGTTCGTATCCGACCGTCGATGGGTGGTATCTGGTCAAGCTCTACCCGGGGGAGTCGATCTCGTTCACGGTGGCTC CGTCGCGCCTGCGCTGGATCCCGACGAACTACATGAAGGCCCCGCCGTTCTCGCGCCTGCCCAGCGGCGCGGTGAAC TTGAATACGCTGCTGACCCCTGGCACGTATGCCTTCACGTCGGCCGCGCCGAACAACGCCCGCAGCGTGGGTTGGCC TCCTGGCGTCTTTAGCCTCGCGGGGTACGTTGAAGTCATCTTGTCCTCTTCGGACGAGTTCGTTCAACGCATCGTTC AGCCCTACATGGCCAGTGGGTTTCATCCTCTGGTCTTCGAACGTCAAGGCACCAGCGGTGGCTCGCTCTTTAGCAAC TGGCTGTATGCCGGCCCGATCTCGCAGTACAGCCACGCAGCGACGGCTGACTGCGGCCCGGTCTGGTGCGACGAGGC CAACACGCTCCTCAAGTGGAATGCCAGCGACAGCAAGTATTACGGCGTGCCCACGTATGCCAACCGTGTGGTCATGA CCAGCTCGGGCAACTGGACGCCTCCCAAGTGGGCGAAGACGGGCCGCGCCACCATCGTCCCTGGTGGTGGTGCAGGT GGCTACACCACCGCGCCCCCTTCGGGCAACATGGGCGGCGGCGCGGGTGGCGGGGGTGCGGGTATTCCTCGCATCAA CCAAGCCATCACCTTCACGCCCAACGTGGCGATGGCCGTCACGGTAGGCGCGGGGGGCACGGGCACCTCCAGTTCGG CCGGTGATGGCGGTCAAAGCTCCTTTGGCGGCTTCACAGTCCTTGGGGGCTTTGCGGGTGCTCCGAACAACGGCTCC CAAGCCGGTCTTGGTGGGGCAGGCGCGGGCAGTGGCGGCACGGGTGGCCCGACCTCGGCCATTCCTGCCCCGGGCAT GGGCGGCGTCGGCGCTCCTAGCTTCTTCGGTCGCGGTGGCGCGGGTGGCGCTCCCTCTTCCTTCGGGGGCAATGCCA CCTCGCTTTCCTACGGCGCGGGCGGTGGTGGCGCGGGTGGCCTGCCGGTAGGCGGCACGGCCCAGCCCGGCGGCAAC GGTATCGGCGGCGTGGTTATCATTGAATATTGATGGAGAACGATATGGACGTTGAAGCGAAGCGCTGGCTGGTGGTG TCGGGCACCGACACCCCGCTGAACGGCGAAGTGGTGAACGCGGTGCTGGCTGGGCCGGGCTTTCGCCTGCCCGGCTA CACCTTGGTGGAGACCGATGAGGGCAACATCGGCTGGCGCTACGTGGATGGGGTCTTGACCCCGCCGCCGACGGCTC CTGGCCCGCAGTACACGCCGACCGAGCTGAAGCGCATGGCCACGGCGCGCATCAACGCGGCGAGCGAGCAGGGCCTG CGCCAGTACATGTCGATGTACCCGGACTACGAGATCCAGACCTGGGCCAAACAGGAAGCCGAGGCCCGCTCCTGGGC GCTGGACGCTAACACGCCCACGCCGACCTGCGACTTCATCATGGCCGAGCGCGGTCTGGACAAGGCCGACTTCATGC AGCGCGTGATCGCCAAGGCGGACTTGTTCACCGAGCTGTCCGGCCGGGCCGCGGGCAAGCGCCAACGCCTGGAAGAC GAGATCTCGGCGCTGGCCGATGATGACCCCGATCTGGCCAGCAAGCTCGACGCCATCGTCTGGTAAGCCGCGCCAAC GACAAAAAGCCCCGCACCTTTCGGTGCGGGGCTTTTTCATGACGGACGCCTGCTACAGCGCCAGGACTTCGGCGTAG ATTCGATTCATCGCCGCACGCAGGGCATCTTGCTCGCCCTTGTTGTTGATGATCACATGATCGAACAACCCATCGGC CAACGGGATTTCCGACTGATGCGTCACATCAGGCTGGGGTGCCCATGGTGCGAAGACCTTCACGAACGTCGTGTCGA AGTCTTGCTGAAGCATCTCGTACTCGGTGGTAAACCGCAAGTCGTCCACAAGGATGACATGCCCAGGGCTGATGCGA GCGTGTTGCTCGATCTTCATCTTGGCCAGACGAACCCACAGGTTCGGGTTGATGATGTTGCGGCCCCACTCGGTTCC CAGCGTTTGCTGGAGACGACGCGGCGTCACATCGAACAACTCCCGGATGGGCATCGACTTGAGCATCTGATCTTCCA TCGACTTGATGGCCATCTCGGGATGGTCGCCGGCATAGACCAGAAGCGTGACCAGCATGTTCTTGATCGGCGCGGCG AACTTCACCACGTCGAGACCATGCGCCGACACCAGATGCTGGGTTGAAGTGGTCTTGCCGTGGGCTGCTGCACCATG GACGGCGATGACTTTGATTTTTGAAGCTCGACTATTCATTTGAAGAACCTCCAGAATCGCCGCCAGCGTCCGAATAG GAGCTGGGTGAGGGGTCAGTATAGGTCGACCCAGAAAACGCGCTGTGGCCCTTCTCCTGGCCTGCCAGAGGGGCGTC GTGCGGATGGGGGTCGTGGAGGGGATACGGATAGCCGATCCGCGTAGGATTCAGGCTCAAAATCGGCGAGATTTCAT CCGAAGAAGTCAAGCCACCATGGTGGCTTGACTTTCTGTCCGTTTCTCCCACACGCGAGAACGAAGTCCGGGTCGGC AGCTCGGCGCTGCCGAGGTCGCGCAGGACGTGGCGCTGCATCTGCCGCGTGACCTGGGCCTTGCGGGTCTCGTGCTG CACGCGCTCGGCGTCCGTCCACGACCGGCTGAGGATCAACTTCTGTTTGCCGTCCTTCAAGTCTCGCTGATGTGCAT CAGCCTCGACTTGGTGGCGGTATTGACGCCAGCCTTTCAGGTTGCCGAACTGAACCTCGGTGCCACCCATCGGGCGG CACACATGCTCGGTGGGCGACGAATGAACCGGGCGGGAACCCACCAGCTTATCGTGGCGCTCGACTTCCTTCTCGAT CTGCGCATTGCCGTCGAACGGCGCATAGCTGACGCGGGCGCAGCGCGCCGTCGAAACCTTCAGCTGCGTCGACAGCG GCAACGATTGCTTCTCGTCCTCGGTGATGTAGGGCAAGTGCCACTGGTCAAAGCCAAGCGGCATCGGCGTCGACACA GCGATGGCCGTCATGATCTCGATGGCCAGATCTCGGATGGTCGGGTCGGCCTCGGGATGGCAACGCAGCTCTTCGAA GTTCTCCCACTCGGTGGAGGTCACCAGCGTGTTCATGTACTGGTAGGCCTCGGTGACGCGGTTGGCCACTTGCTTGT GCGCGCCCAGCTTCATCATGACCCAGGAGCCAAAGGCCGAGATCTTGGCCAGCGTGCTCCAGGTGGCCTTGACCCCC CACAGGCGCCAGCCCGTCAGCGGCGCGCCGGCCTGCATCCCAGGCTGGTTGCTGCCCCACTCGACCGGCGCGGCCGG CTCGCGGCGGATCTGGCGCAGCATCTTGGCCGTGGGGATCGCCCGCGAGGATCCTGCGTTGCGGCTGAAGACGCGGT GCGTCATGAATTCAGAATGCACGATGCGCGGATACCGCAGGGCCAGCGTGGTCACGCGCACGCCGGCCGGCGAGATC GAATCAGCGATCACGACCGCTGTGATGGTAGGTTTAAGGTTCATATGTCCTCTGTTATAAAAACCCGCCGCCGCCCC TGGCGGCGGGTGGCTTGCCGGGATTACGACGCGGTGTGAGCAGCACCATCCTTGTCGGCACGCGCTTCGGCCGCTTG ATCCGAGTAGCCGGCTGCGCCGTAACGCGCCTGCTGACCCGAGAGCAGCTTCTGGTTGTTGTCGATGAAGAGTTGTT CGAGGCTGTTGCCCAGCAGCTCGGCGGTCATCTTGACCAGATACAGCAGCTGGCCAAAGGCGATGTTCAGCTCGACC TTCTTCTGGACCAGGGTGTCGTCATCATCCATCGCCATCTCGGACAGGCCGCCCACGAGCTGCCCCATGGCGAAGGT CAGAAGTTGCAGACGGTCGAGGTCGTTCATGTCCTCGCTGAACTCGACCACGTACAGGATCGGGCGCATCTCGTAGT TCGTGGCGTCAAAGCCGATGGCCAAGTACCAGCAGGCATCAGCCAGCTCTTCGAACATGCCGACACGGGGCGTGGCTTCGCCTTCCTTGCGCGCCGTGTCGATGTCCTTGCCGTAGATGGCCACGCGCTTGACCTGACTGGCGAACTCACCGAT CTCGGTGAAGCAACCGATGATCGCATGGCGCAGGCGCTTGGGAAGCGGGAAGGGCTTCTCGGTTTGCAGAGCGCCTT GTTGGTAGGTGAGGATGTCCATTAGTAAAGTTCCTTCTGAGCGGTGAACCATGCGGTTCGGGGTTGAGAGATCGTTG GTATTGCGTATTGGATGATGTAGTCGCCCTCTCGGGCTTGCACCATCGAAAGCTTGCCTTGGTCATGCGCGAGGCGG ACTTCAGCCAGAACCAGCAAGTCTTGTTCCGGCCAAGCCCTTTCCCAGGCTCGTTTGCGCGAGACAACCAGATGGAG GTTGTGCGGGGCACCCCACCCCACCATCCGGCATTCCTTAATCACGGTGACAACATCGTCAACCGTGACCCCTAGTT GACGGGCGATGGTCATCGGCCCGTAGCCCTTTTCAAGTAATTGTTTTATGTTCATTGCTTCAATGGCAATTCGTAGA TTACGTCTGCGATGGGTCGCTTGTGCGTAACCAGGATGACTTGCCGGATTGCGGGAGACAGGCGGCGCAGACATTCC GCCGTGAAGGCAGCACGTTCATCATCCATCCCTTCGTCCACCTCATCAGCTTGGAAAGAAGAGAAGATCCGATTGGT CATGATCTGCCCAAGGCCGATGCGAATGGCAAGATTCGCAACTGCCTTGCCCGAACCAGACAAGGTAGCGATGTCTG ATCCGTCAACCTGGATGTCGAAGTCCTCCGAAATAGTGATGTTGTTCCGAACGCCACCCGTCATCTGCGACAACAAC AGGGACGCCACCTGATTCAAGGAAGGCACCAGGAACGACTTGATGACCACCTTGGCTTCCTGCACCGCGGCGCGGGC CTTGATGAGATCTTCGGCCTCGGCCATCAGGGCTTCCATGCCGGCGACCTTTTCCTCGTAGGCCGCCAGCGTGAGAA CGAAGTTCTCCGATTCGATCTCGTACTGCTTGGCCTGCGCCGCCATGGTGATGATGCTTTCCACCTTGGCTTCGACA TTCTCCAGCTCGATCATGCGATCACGCTTGCGCTGGTAGTCGGCCATGAAGGTGTCATAGACGCGCTTCTTCGCATT GAAGGTGTCCATGGCCAGATCGAACTCCTGGCGCTTCTTCAGGTCGTCACTGCGATCCGGCAGGCTTTCCAATCGCT TGGTCAGCTCGGTCATTTCGTCAGTCACCTTGGTCACGAAGTCCTCGGCGTCCTTGAGCGCCACGGTGTACTCGGCC ATCGCCTGTTCGAAGTCGGCGTCGGCCTTCTCCACGTCCTGCTGGTGCTGCGCCTTCATGCGCTCCCAACGCTGCGC ATGGTCCAGCTTCAGCTGTTCGATAGCGGCCTCGTTGGACACCACCTTGGCCTCGGCATTGATCTGCGCCAGCGTGA GTTCGGGGGCCGCGCATTCCGTGACGGCCTGCCAGTCAGGGTGATCCAACTCTTCGGCCACCGGCCAGTGGTGGTCG CAGGCCGGGCAAACGTGCTCGCCGCGCTCGATCAGGCGCTGTTTGGCCAACCACGCTTGATGGTCGTGGAACTGCTG GCGCATGGCATCCAGCTGCTCGGGCAAGTACCGGGGCACGATCAGCTCGGGCAGCTTGAGCGCAGGTTCAACGACCG GCGGCACGACACGCAGCTGGGGTGCCTTCAGCTCGTCGCGGGCCTTCCTGGCACGTTCTGCGCGGGCGATGGCGTCG GTGAGCGAGCTGCGCACCATCTGCCGGTCGTGCAGCAGCGTCTGGAGCGTGGCCACGGTCTCCTGCACCTCCGTGGT CGGCAGCACGGGTTCCTCGGGCACATTGGCCAGCTCGGCCTTGAGCGTGCGGAACTCGTCGACCAACGGGCGCGTGT TGGCCAGCTCGATGGCCAGGGCCTCGGACGAGGTGTAGCCGGCCGGCGGCTGGGGTTCCTGCGGGCGCACCAGCACT TCGGCCATGCCCTCGGCGCGGCGGCGCTTCTCCAGCGCCTCCTTGCCCAGGTCTTCGGCCATCCCGTCCAGAATGTG CAGGCCGATGGTCTGGTCCACGAGGCGCTTGCGCTCGGCCGGCAGCGCGTCCGACAAGGCTTCGATCTTGCCTTGCA GGCAGGCGTTGGCCATGGCGTAGACGGGGTAGCCGTAGCCGAACAGTTCGATGATGCGCAGGTTGACGGGCTTGGTG CCGGTCGCAATCGGATCCCCGCTATTGTCGTAGAGCGCGGCGTTCTTCAGTCCGCGTTCGACCATGTAGCGGTTGCC GCGCACGGTGAATTCCAGCTCGACCTTCAGATCTTTCTTGTAGCCTGTGGCCGACACGCGCAGCGCCTGCACGCCCC ACAAGGCGAAGGCAACCATCTCCAGGACCACGGACTTGCCGGATTCGTTGCGCCCTATGATCGCGGTCTGACCTTCA CCGAATTCGAGAGTAGTGTCGTCGTGACGGTAGCCGTTCTGAATGCGGATCTTATGCAGCATTTGTATTCTCCGTGT AGGGGGTGTACCCATACTGAGCCTGTTCAGCTTCCCGCCGACAAGCGATTGCTTGGTCTAGGTCTTTGAAGACCCCA AGATAGACGCTACCTAGGAGGGCTTCGTAGTAAACGTGTTTGCCTTCCTTCACCACTCGGCGCACTCCGGTAGCGTC CTTCTTCCTGTTGTTCTTGCTGTTGTAGCGATTCTCAGCGTAGGTCACGACCCGAAGGTTGGACGCACGACGGTTGT CTAGGGTGTCGCCATTACGATGGTCTACCACCATGCCTTCAGGAGAACCCATAAGCTCACGATGAACATAGTCAAAG AAAGATCGCCCATTGATCTTCCCTCGATACGTCTTCGCGTATTCATAGACCCCGTAGGGGGTCTTGATCGTGTCGCT CAGAATAGTCCTCCCTTCGAACAGGTGTAGATCCGCAGCATCCAGAAGCATGACGCTCCCCGTTCTTTCGATCTTCA CCTCCACGACGGCAGGCTCAAGCAGCATTGTGGCGCTCCTTGTACATGGCCAACACCTTCTCAGCGGTGGCCGGCGT GACTTCGTGCTTGGTCATGCAGCGCGAGATCACGTCAATGGTGTCGAAAGATTCAGCCTGGACGGAGATGTCCACGA AGTCTTCGCCGTTGTCCTGGATCAGCTTGGTGGTGATCGCCCAGGCGTCGATGGCGATGTCCACCTTCTCGCCGGGC TTCAACTGCACGCGCAGCGCCTTGTCATGGAAGAAGGTCGGATCTTCAGCCAGCTTGGCCTTGACCGCTTCCAGCGT CATGGTGACGTACTGCTCGCCGTCCGGGTCTTCAGCGTGCGAGTACGGCTGCATGGAGCCGGTGTACATGATCTTCA CGTCACCCAGCTCGTATTCGCAGGCGTTATGGTCGTGACCCGAGACCAGCAGCTTGCAGTAGGGGCGCAGCTCGTTC AACGGGATGCAGTTGTGCGGCTCATCATCGAACGTCACGCGGTCCCAGTGGCCAACCACCAGATCGAACTCATAGTC GTCGGCCGTCAGCTTCTTGGCCATGTCCCGCGAATTGATGAACGGATGCCACGGCAAGAGACCGATGCGCAGCACGG AATCGTGGAACTCCAGGATCTCAGGCATGTCTTCCGTGATGACCAGACGGTTGCCCGATTCGATCATGCGTGCCAGG ATGGCGTAAGACGAGACCTTCGACACGTCACGCGAGGCATCGTGGTTGCCACGGATCACGACGATGTGCAGGTCATC GTGGTTCATGTAGGCGTCTTGGATGAGCTGGAAGAAGCGCATCACGACGGCGTTGGGAACCGCGAACTGGTCGAACA CGTCGCCCACGATGATGACCACATCCAGTCCTTCGGTGTTCAGCTCGGCTTCCAGCTGTTCCCACTGGCTCTCTTCA CGTTCCCCACGGCGTTCCAAGGGAACGCCGGTCTCGAACTTGCGGCCCAGGTGGGGATCTCCGATCAACCCGATCTT CTTGCCGTGCAGTTCAATGATCTTCATGTTTACTCTCCGGTAAAAAGCCCTCGGGGTTTTACGCCGAGGGCTGTACT GCGTCGTTGTGGCCTAGAGCTGGAAGGCCGGGTGAGGTGTCGAGTGGGCCTTGGCCGTCAGCATCACCTTGATCTGA TGCAGCACGTCGTGGATGGCGTTGTGGGCGTCACCTTCGAACGGAATCACCGATTCCAGCGGCGGCGGATCCTGCGG GAAATAGCGACCGCGCAGGAACGAGTTCATGTCGTTGGTGTAGCGGTAGTGGAACGGGTTGCCCACGCCGAATTCCT TGAAATAGGATTCCAGGAACGGGTATTCGAAGTGCGACGGCTTGGCCCACAGGATCGGGTTGTCGTTGTAGGGGTCGAGATCGGCTTGCACCCAGGTCTTGAAGTCTTCCATGACCTTGCCCGGCTTCTCGCCGCGACCGAGGATGCTGCGCAG CAGATCGGCCTTGTCCTTCAACCACCACGTCCGGGTGTCTTCTTGCCAGAAGCGGGTGGGAGGCATCATCAGGCAGC GGTCGAAGATGTGCGGCGAGATCGTACCTTCCTTCAAGTTGAACTTGACGGCGGCGATCTGGATGATGGCGGTCGTT TCCGGCTGCGTGCCGGTCGTTTCCATGTCGACCATTACGTCCGGGAAGAGTTGAGTCATGATTGCAGTTCCAGAGTG AATTGTTCGAGAGAGACAGAGGGCATGTCGCTCCACTTGACCGACTTCGAATCATTGTCAATCAGATGGATAAACTC GTTGGCGTGAACCACATGCCATTGGCGGGTAACGATGTGGTTGATGAAGAAATAGTAGTCACCACCCGCCGCCACGG TCTGCCGAGCGCACGCCATTTGCTTGGGGGTGATATTGCCGAAGGAGAACGATGTGCCGTTCTCGGATTCCTTGACC TCGGCATAGAACATCCTGTTGTAAGCCGTGACAAGGTAGTCGGCCGGCTGTGCATCCTTGCGAGCCAGCCGGTCTTG CTGCTGGCCCATGACGAATAGGGTATCGGTGAAGCGTTGAACATGGACCCGCTTGCCGTGGGGCTTCCACCAGCTCT CGAAATAATCCTCGGAGATCTTGCCTTTGCTGCGGGCCATGGTGCTTCCTTCATGAATGAAGGTTGCATTATAGGCC GGAATACACCGAAGTGGTGTATTCCGACCAGACTTTTTAAAAGACCTCGCCCTTGTGAGGCACCAGGGCAAAGCGCG GCACCCCGGTGTGATGCAGGCCTTGGAAGTTGTCCACGGTGCGCGTCCACAGCCGGCCGTCATGCAGGCCTCGGAAA GTCACCGAAGGGAACTCGGACCCTTCCAGGGTGATGTGGCCCAGGCCGACGACGTGGTACTCGTGGCCATTGACATG CCGGTAGTTGCGCCCGGGGATGATGTCGGTGGTCATGGTCATGCTCCTTGATGCTCGTGAAGACGCACGTAAACAGG GTTCTTCAAAGAACCGTCCTTGGTGATCTCGATGGCTTCGAGCACCACGCGCTTGCCGATCACGGCATCCGGGGCGC TCCACCAGAGGCTGCGTGTGGCCAGATCGAAGCCCGAGCCGCACTTGCTCTTGAAAGCGGTGCCATGCTCGTCCACG CCTTCGACTTCGATGCCGCCCATGTTGCCTTCCAGCGCCGACTTCTTCTTGCCTTCGTACAGGCCGGTGATGCGACC GTCGAACGTCTGGAGCGGCTTGGCCTTGAGCCAGTTCTTGCTGCGCTTGTATTCGTAGAGGCCGCTGGGGTTCTTGA TCATCAGGCCTTCATAGCCCTCGGTCACTGCGCGTTTGAGCGCGGCCGACAACTCTTCCTGGCTGTGCGCCCACTTG ACAGGACTGGGACGCAGCAGCAGGTCGTCTCCATACATCCGGCGCATCTGTTCCATCGCGGTCAGCAGAAGATGGGA GCGCGATTCCTGGTTCAGGTGGCACTCGGCACTGTCCCACTGAACAATCGGGATCCAGTCGTAGATGAAGTAGCGCA GATTGGACCTGTCAGCGCCTTCCTTCTTCGACTCCATGGTGGCGTTCCAGGTGTTGGACTTGCCACCCGGGTTGAGC TGCTGGTCCATGACTTCGCCATCGAGCACGATGCCATAGTCGTTGTTGTTGGCCAGCAGGAACCGCAGTTCATCGAG CTGGGCATCGAAGCGGTCTTCCAACCACCCCTTGCGCTGGTCCAGGCCGTCGCGGGAGCGCATTTCGAAGTGCAGCA GCGGACCATCGCCCGGACGCGGCGTGGTGTTGATGAGCGTGGTCACACGCTGACCGTCGTACTTGGTTTCATACATG ACGGGGAACGTCACGTCGGTCTCGCCCGGCAACCACTTCTCGGCCAGCATGACGTTGAAGACGGGGATGAAGCCCGG CAGGATCTTGTTCATCTCCGTCGCACCCATGCCCACGCGCAGGTTCTTGCGCAGCACGCAGGCCAGGGCCTCGGCCG TCTCCTGGGGATACAGGCTGAGGACTTCGGTGATCTCCTTCTGCGCGGCCTTGCCGGTCAGCTCGCGGCTGGAAAGC TGTTCCAGCAACGAGAAGAAGGTGTCGATGGGCTGGCAGCTTTCGGTCGGGTAGGACGTGGGCATGTCGAAGTTCTT CACGCCGAACGTGGTGAACGGCGTCATGGCCTGGAAGATCAGGTCATGGCCGGTGCTGGGCGGGCTGCCCAGCTGGA TGAAGGCTTCGGCCTTCTCGATGCGGCTGCTGGTGGCCGCAGCTTCACGCATGAAGCGTACAAAGCGGGTAAGACTC ATGATTGGTCCTTGTCGGATTTGTTGTAGATCGCCTTGGCAAGTAGCCATGCTTCGTAGAAACGACGCCCCTTGGGC GTCATCTGATAAAGCCGAAGAAGGCGCTGCACATCAACTCGGGACTGTATGAGGCCTTTGTCGGTGAGGCGATCAAG CATCACATAGATTGAACCCATCTTGATCTTCGGACCTTCCTTGTGCAGTTGAGCACCGTAGATCTCCCCCTTTTGCT GGTGCAAAAAGAGCATGATCTCATCTTCGACTTTGGTGAGCATGTCAGTCCCTTAGCTGTTCTTGAATTCTTGCCAG TTGACGTTCGGGGCTTCTTCGCTCAAGCCATACAGCCAGTTCTCGGCTTCGACCACGGCGTCCAGCAGCTCCTGGTC GAAGTCTTCGCCCAGGGCTTCCTCGCCCCACTTGTCGAAGATCTCGTCATGAGTCATGGGGCCGGAAAGCACTTCGA CCTGGGCGTCCAGCGCCGGCTTGTGGAAGTTCGGAATGAACTTGCGGCACTCGGCCAGCTCGTTCAATTCCTTGGCG ATCTCGGTGTCAGTACGCATGGCCATGTCACTTCCCCTCGACCAGTCGGAGCAAGTCCTGCGCGAGCATCGGGTACT CGCGCTCGCAGTGGCGGGCGTAGGCGCGCAGCACGGGGCCGGCGAACTTGTCGTGGTCGATGTCGATCACGAAGTAG CGGGCACCCTCGCGGTCACCGCCCGGCTGGTCACGACCGTCATTGCGGGTCACGGTGAATTTTTCGTACAGCCCCTC GGGCTGTACCTCATTGGGGTTGAAGGGGTTCATATGGACTCCACAGAAAGAGCATCAGAGGGGATCTGGCAGGCCGA TGAGATCTGGCGATACCAGAGAAGGAACTGCCCGCAAGCCTCGTCATGCGACCAGACATTGGGCAGGTAGAAGGATG GGGGTTGCGACAGGCCGGCCAGCGTCTTGGCGTCGATGCCGGCCTTCTCCAGGCAATCCCAGCGGTCCTCGTTGCGC AGGATCAAGCGCTTTTCAAGCGCCAGCGCAACGAGATCCGCGTGACGAACCCGGGGATCATGCTCCGGGTCGAAGTT GAACCAGCGGGCCATGTGGCCGTGCAGCTCGTTCTCGATGCGCTGGTAGTCCGGCAGCAGGCGCTTGAGCGGCGAAA CGATGTCGCCCATCAGCGCCTCGGTGGCATCGTGAAAGAGACCCATCAACCACAGCTTGGGGCTTCGCGGGTAGGCC TGCACCAGCAGGTTGGTCACCAAGACGCTGTGCTGCGCGACGGTGTACGGCCGGCCAGGGGTCTGGCCAGCGTAGCG GGCCACGCAGGACAGCCCACGGGCAATGTCGGCCACCGTCAAGTGGCTGTTGGCCCCGATGTTGGCCCAGTCGAAGT ATTGGCCGGACAGCAGCGAGATATCGGTCTTATGCGGGTTCGTCATGTTCTGCCTCCTGGGCCTTCTTCAGGTTGTG CTGGGCGACCAGCAGCTCCCACTCTTCCTTCTTGATGCGCCGGCAACCTTCCAGGCCGTCCGGATCGTACACCGCGC ACGGCCCGGTGACCTTGTAGCCCTCGTCTTCCTTTTGCTTGACGTAGGCGCGGATGTCGGGCGTCCACATCGCATAA GGACCGTCCTTGCCCAGGTACAAGAAGCCCACCTCGTGCAACGGGGGCCACCCGATGTGACGAAAGCCCTCTTCGGA TTCCTTGCCGTCTTCGATCTTGACGAAGGAGAGCGTGAGCGGGATGTTGTAGGCGTCCACCAGATCTCTGGGCTGGA CTTCCACCGTCGGTTGCTTGTCGAAGCGGTCAGCCCAGTAGGTGCCTTTCTTCGGGTGGCAGGTTTTGTTTTTGCCG CTGGGCTTGGTGAAGTCCGGATGGTGTTGACCACGCTCGAACTGCACGCCGATCAAGGTGCCCTTGTCGATGTGACG GTACGCGCCGACCACCTTGGCCTCGTCGCTGATCTCCTTGATCAGCGCGGCGCGAGCGCCGTCAGTGGCGATGATGTCGCGGATGTGGGCCTTCACCAGTTCGAGCGCTTGGCCGCCTTCGATGAGGTAGTAGAGCGAGGGGATGTTGGGGTTC ATGCGACTTTCCTTTCTTCTTTAGGGCCGTCCAAGAGATAGTCGAGGATGGCTTGGCGTTCTTCATCGTTGGCCGCG TTGCCCCACGAGGTTTCAGGCACACACGGCACACCCTTTTGGATTTCCATCAGTTCGATCTGACCGTTGGGGGCCTT GTCCAGGCTCCACGGTTGCAGCGTCTTGCCGATGGCCAGAGACGAGTCCAGCTTCAGGTTGTTGATCAAGCCAGCGC CGTCGATCATGACCTCGTAGAGATCCTTCATGAAGGCGAGAGCTTGCGAGCGCGGCACCGAGTACACCAGCTCGTCG TGGATCAGCAGGAAGAAGCGGGCGCGGTAGCCTTTCTCCTTGATCACGGCGTCCATGTGCTTGATCTTGCGCTTGGC CAGCGCGGCGCACAAGCCTTGCACCATGGAGTTCACCGCTTGGTTGCCGGCACGGCGGTTGATCTTCTTGATGACCA GCTCGCCGAAGTTGGTGATGGCCTCGACACCGTAGTGCTGGAACTTCTGGCGCATATGCATCACCCACTCGTGGGTC GACTCATAGCGGTCGCGGCGGTGATGATCGGGCAGCTCGACATAGCCGTTGTCGCGGGCAAAGTCGATCACGCCCAG ACGCCAGCCTTCAGCCTGCGGGAACGTGTTGCGGTACTTGTCGGATTGCTCCCACATCTCTTCCGAGGACCAGCCCA TTTCCTTGGCCGTGGTGCCCAGCGCGCCGGAGTACCAGTAGCCGAAGTTGGACACCTTGCCGATCTTGGTCCGCATC TGTTTCTTGTCCGGGTGCTGGTCGTATTCCTCGGCGGTCATGCCAGTGATACCGAGCACGGCGAGCTTGTGCAGGTC ACGGTGCGGGCGCTGGCCATAGGCCTCGAAGAAGCCTGCATCGCCCGAGTATTCCCCGATGATGACCAGCTCAACGG CGGACCAGTCGGCCGAGATCAGGACATGCTCTTCGCCCTCGGCGTCGTCATCGTCCGCTTCGAAGAAGCCGCGCACG TACTGGGATTCACCGAACTTGGCCAGCTGCTGGCCATTGGGGGTCGAGCAGGCCGAGCGCCGGCTGGCCAGCAAGCT GGACAAGACCGGATAGACGCGGTTGGTGTCCGGGTCGATCAGGTTCAGGTACGGCGTGATGTACAGCTTCACGCGCT GCGAGATCCCGGCCATCTTGGCGTAGGCATCAAACACCCCCAGGCCGGCCTGGAAACGGTCGTAGGCGGGCTGCAAT TCCTCGGGTAGGGGTTCGGTGCCAGGATCCAGTCTATTGCCCTCAGCGTCGATTACAGCGAGCAGTTCGCCCTCGGC GTATCTTTTGATCCAGCGGCGGCGCAGCTCGGCGCGGCAGTCCCCATCCGATTGGGTCTTGCCGTTGACCAGCATGA AGCTGCCGCGCAGCAGGTCGTACAGGATGACGCGCATTGGCATGTAGTGGACCAGATTCAAGCCCTTCGATTCAGGC TTGCCCTGTTCCAGCGCCCACGCCGCGGAAACCGGCGAGCGTACCTGCATCACCTGGGTGAAGTCGTCGTCGCTGTC CGGGCTTTGCGCCCACGCTTCGATCTGACGGCGGTACTTTTCCCAGTTGCCGCTGCCCTTGGTCTCATCCCAGTACC ACTTGTCGTACTTGGCCAGCTTGTCGTGCATCGCGGGCGGGAACGGCAGCAGCCCACGAACCGCCGCCTTCAACTCG CGCAGCGACTGCGCTTCCAGCGAACGCTCGACCGAACGGCGGTCGTACACGGCCTTGGTGTTCATCTTGATGCCGTG TTGCCAGACCTCGGAGGCCTTGCGCACGAACGGCATTTCCTGTTCCAGGTAGGTCTGGAAAACAGGCGGGTTGGTCT GCATGATGTAGGCCAGCACGGCGTGGAACAGCTTGACGCACCAGTAGGCGTCGTCCACGCCGTAGTCAGCGACTTCC TGGCCAGTCAACTGGCCCATGTGGACCTTGCCGTCCAGGGTCTTTTCGAACGTGGCCATCTCGTAGCCGAACCACGA CTTGACGGCACGCTTCAAGTCGTAGCCAATGCGGATCGAGTCGACGTAGCCGTTCCACGAGTGTTCGGCGTCCGACT CCTTGGCGATGATCTTGTACAGCAGCTCTTCTTGCTCGTTGCTCAACTCCGCGCCCATCTGGTAGCCGGCGAACACA CGCTGCACGATGGGCAGCATCTTCTCGATGCCGCCCAGGCCTGGACCATAGAAGCGATCACGGAAGTACGTGTCGGG CGAGTACGCCGACACGCACAGCTGCATGGAGCACAGAACCTTGTCGCCCAGATCGAACCCGAGCGCCTTGGACATCA TCGTCCACTCGTAGTTGGCGTTGTGGATGACCCAGTAGGACTCGGGCTTCTTGGAAACCAGGATGGCCTTGGCCAGC GCCCACGGCACACGGTTCTCCACATCCGCGTGGGCGAGGTTGATGTAGTAGGCGCGTTCGCCCTTGTCCGGGTATAT CGAAAAGCCGGTCACGGTGGTGCGGTTGACATCGAAGACCAAGCGGGCGTTGGCGGACTTGCGCCCATCCTCGTCCG TCTTCATGAAGCGGTTCAGCCCTTCGTGACGGTCGGCATCGTGGGTCTCGATGTCAAAGCCGATCAGCCCGGCGTTG GCCACCTCGTCCATGATGATGGGAAGATACTGGTCGATGTTTCTGGCATCGACCAGTATCTTGTTCTGTTTCTCCAG CATGTTGGCTCCTTAGAACTCGCTCGTGCGCACGCAGTCGCCAGTGAAGTCGTGCTGCGTCATCTTCACCGGCATGT TGTGCTCGTCAACGTACAGCACCTTGGGTGCGACGAGATCGATGTTGTCGGTCTGTTCCCAGACGTTGATCACGATC TTGTCGCCCGGGTTGAAGAAGTGCGCGGGCGGGCCGTGCAGCGTGATCTCGCCCGGGACATCGGACTCGATGACGTA GGTTTCCCAGTGCTTGCCGTTGGTCACGCTGTTGACATCGACCTTCTCGAAAGGTCGGATGTTGGCCAAGGCCAGCA GGCGGCGGCACACGGCGATGCTGCCCGTGTATTCGAGGTTGGCCCCCGTGACCGTGGCACGGTGGATCTTGGCGCGC AGGAAGGTGCGTTGGGTGTGAGCCATCACGCACGCCCCTTGCGCACATCAGCCACCATCTCGTAGCGCCCCATGGCC AGCGGGTACATCGGGCGGTTCTCGATGGTCACGACCACGTTCAGCTCGCGGGCCTCGTCCAGCAGCAGCTCGACCTT GGCCTGGATGCGGCGCAGGGCTTCTTCATCGTTCACGGGCGGCGCGGTCTTCCTGGCGGTGTATTCCAGGACTTCGC GGCGCGTGATGACCACGGTGGCGCGGTTCTGGCCGGTCGGCTTCCAGCCCAGCTTGTTCTTGCTGGGCACGTAGGAG TCGCCTTGCAGCTGGATGGCGTCGGTGCCGATGCGCTCGAACAGGTAGAAGGAGAAGTTCTCCGGCACCACCATGGT GTGGTGCAGCTTTTCCCAGGCGGCCAGCACGTAGTCCGGGGCAGGAACGTGTACGCCCAGCACATCTTTGTATTCGG GGGTGGCCATGGTCAGACTCCTTGTTGCAGAATGGTCAGTTGGGCGGCGAGGCCGGCCGTCGTGAGCGCCAGCACGC CGATGGTGCCGTGCTCTTTCACGATGTCCAGGATCTCCTGGGTCAAGCGCTCACCCAGTACCCGTTCATGTTCAGGA AGACCTTCGATGATCTCCTTGGCTTCCATCAAGTCCAGCTTGGCTTGACGGATCTCTTCAGGGGGGACTTTCATAGC ATGTATCCTTTTAGAATGGATTCGATTTGCCCGATATTGGGAATGCCGACCTTCATGTACTTCTGGAGCGCCGCGTC GGGCACGTCGCGGAATCCGATGATGTCCCACATCTTTCGAAGCATCGGCTCGTTCCCCTTGATCCACTTCAGGGACG CTGGCTTCAAGGCCAAAGGCTCGGCAAATGCGTCCCAGTCTATGGGTATCGAATTTAGGAAGTAGTCGAGCCATATC TTTTTGTCCGTGTTGTTCCAGGCGACCTCTCCGAACTTGTAGACGCCACTGATGGAGTCCGAAGGGTCGCCGACCAG TGTCTTGCGCAGTCGCACCTCCATCCAATCGGTGTTGTTGTAGACCACGTTGTCTCGGCCATGGATGGTCACGTTCA CGCCATCGCACAGCGCCAGGAAGTCGCCGTCGTTCGAGTAGATCTTGAACCGCTGGTTGGTGTTGGCGCGGGAGCGC ACGAGTGCTGCGATCACGTCGTCCGCCTCGTAGTAGGGGACTTCGACTTGCACGCAGCGCGTATGCAGCAGCACTTGCTTGAACAAGTCCTGCGTCTTGTAGAACTCGTCGGTGGCGCGCACGCGGCGCACTTTGTAGTTGGGGTAGATGTCGC GGCGATATTGCTTGGAGTGATACCCATCCCACACGTAGATGACGAGATCGCCGGCCGGGTACTGCATCTGGATATCA GCGAGGACGCCACGGATCAACCCAGTGGCTTCAAAGACTCGACGGAAGGTGTTGTTGCCGTCAATCAGGTGAATCGT GGTCATACCTTGAACCTATTATGTTTGCTTCGATTAGCTTCCATGGTCTTGACTTCAAGATTCCACGGAACATGAAG TCCACACACTTGCGGATGCCTCAACGGCACAACATGATCAACCTCGTGAGGGATGCCGGTGGCTTCCGTGAGTCTGG AGGCTTCGTTGTAGAACTTCTGGATAGCGACCAGATCCACCCAAGGTGGGCAATTGTCCTTGTACTTGTAGCGACGG GAGGCCTCGGTGTTGTGGCCTGGGTTCTTCGCCTCGTACCTTGCCTTACGTCGTAAAGCTGCTTCCTTGAATGATGT TGTGCCACGCTTTGCAAAAAGCTTTTCCTCTTTGCACATGACACAGTGACCATCACAGACCCATCGTTGTGAGTCAT GGCCACGGATACACGGATTGCCCGTGTAGTAATAGGAAAGCCCTTGGGCTTTTGCATCGGACTTGGAAATCGTCAGC ATAGATACTCCAGAGAAAAGGCCACGCCTTTCGGCGTGGCCTTGATGACACGGACTTTGACTTACTCGTCGCCGCCT TCGTCCTGAACCATTTCACCCAGGAGTTTCCATGTCATGATCCCCCAGGTGTTGTTGTTCTTGTTGGAGCGGGCTTC GAAGCTGACTTCGACTTCCACGCACTTGCCCAGCAGTCCGGCCTGGGCCACGGCCTTGTAGAAGGACTCCCACGCGG CCCAGTTGGTGGTGGCCGTGGAATAGCCCAGCTTCTGGCCGGCCTTGGCCAGCTCGGTGCCCTTGGGCGACTTCACG TCTTCCAACAGCACCATCGGCACGTCGACCGAGCGGTACGGACGAGCCTTCGGATCCAACGCGACCGCCTTCTGGAT GGCCTCGTTCCAGGGGATGCCCTTGTCCGAGGTCACGCCGTCGTAGGTCGACCAGTATTGCGCGGGGTTGCCGGCCT TGATCGATTGCTTGGGCGAGAAGCCCACGCCGTCGGTCATGTCGATGTAGGCCTTGAACGACGGGACCAGATCGGTG GTCTGGCCAACCAGCAGGCCAAACTCCTTGACCTTGACCCAGACATCGACGGTCATGCCACCAGCCATCAGCTGTTC CATCGACATCTTGGGGCCGGGGGTCATGGCCACCGCGCCGCCTTGCTGGGCGGCGGGAACCACCGCGCCCGCTTGTT GGGCAGCTGCCGCAGCAGCAGAAGCTACCGAACCCGCGGCTTGTTGCGCTTGTTGAATCGCGTTGGTAATTGCGTCA CTCATGATAATGCTCCAGGGTATGTTTCAGTTCACGTATGTCTCACCAACTTGGTGAGATGGCAAGATCATACCATG GTTCTTCAAGGATAAAAGATCTATTTACCCGATAAATCCGGGTTATTGCTCTCCTTCAAATGTTCCGCGTTGATCGA GTCAACCAGCGCGTTGAATTGGTTAAGTGGGATGTCCCAGTGCAGATGGGATTCGATGTCGACTTGCATGTCGTACT CGGTCCCATCCTGGCTTTCATACTTGCTGAACACCAGATGGCCGAGAATCATGATGCCCTGCGGACCCACAGGTTGT TCATCAAGATTCACGATGTTCTTGGCCGCTTCGAAGACGGGGAAATGCTCCCCCAACATATCGTCAATGGCCAATAC GTTGTCGCACATCACCTCTTCTTCGATGATCTCCAGCTCGACTTTCTTGGCTTCAGGGTCATCTTTCCAGGTGTGCA GCTTGACCATGTAGGCGAAAGGCACTTTTCCAGTGATCATGGCTGCTCCTTGTTTTCATGGTTGACGCGGCGGTCAG TGACGAACGGCACGCCCTTCAGGTTGCGAACGTCACACAACATGCGGGCATTCAGATACCCGGCGCTGTCTCGCACG CGCACAAAAACGCGCTGGAGATGAGGATTGCCACCAAGGTCGCCCCACACGTAATAGCCGACGACTGTATGCCTCAG CCATCTATCCCGGCTGGCAAGGTGAATCAGCACTTCGCTGCCGATTGGAGGCAATCGGTCACCATCAACGGGTTCCA GGGCGCTGGCCGGGGGCGCGGCGTCAGTCTTGGTCGGCTCCAAGTAAACCGGGATATCCCCGTCCAGGGCGCTCGGG CCGAATTTGGCGCTGCGCAGGTTCGCATCGTGTCCCGAGTTCAACCGGGCCAGCTCATGGGCGGCCACGTAGCCGAT CGGCCGGTCGCTGTCGTCCTTGGGTGAAGCTGGATCGCCGCCCTTGTCCGCCTGGGGCGCGGCAAGATCATCACCAC GCTCAAAGCCGTGCCGGTGCTTGGCACAAAAGCCGCACGGGCATGTGGCGCGTGGCAATCCGCTCCCGATATGCACC CCATCACAGTATTGGCGTTCGACGGCTTCCGCAGTAAGCACCTCCCCAGCTACAGGGACGCTTGCCAAGGCGGCGCG CTGGCGATCAAGCCACCGAACCGCGGTCTTCTCGGCTTCCTGTTTGCTGGGCAACCCCGATGCGATTTGAAGGGACT TGCGGCCCTTACATCCGTAGCGGTTCACATCTTCGAAGATGTCGGTGCCGTCAATCCGCACACACCAGCCGCTGCCC ACCGTATCAGTGACTTTGATGTCTTCAATCCAGTTGAGGTCCGGTCGCTTGTCCTCCTTCGGGGCGCGCAGCTTGTC CAGTTGATCCGCAATCTCCACGACCGTTGCCGCGTCCAGCACGACTTGCCCTGTGGTAACTGCGAGCTTGGCGGCGG CTACCGCCGTATCCCAATCTTTCTGACTCATGACGCCTCCATGAATACGGCCATGCTGGCCTTGCGGTCAGCGATCT TGTTCACGTCGAAGATGCCGCCTTCAATGGCTTCTTCTTGCAGGTTCTGGGCCGACAGCTTGAACACTTCCTTGGTC GGATCCACCAGATGCGATTCACGAGACTTCATCTCGATGATCTTCATGATGCGCTGGTCGATGGAGTCTCGGTATTC CAGCACGTAGATGAGCAAGGGCGTCTCGCGCTTGCCCCGGATACCACGGCGATATGCCTGCATGAACGAGTCATCCT GGTAGTCCAGCGAAGCGAAGACCATCACACGCAGGTGGTTCCAGTTGAACCCGATACCAGCCGTGGCGGGCGAAGCC ACCACGCAGTCGAGCAACCCAGCCTGGAACTGGGCGTCGATCTCGGCGCGCTTGGCGGGCGACACCGTGCCGTTGAT GAGGCCAGTGCGCAAGCCCATGGACTTGGCCAGCTCCACAATGCGCTGCTGCTCGGGAATGAGCGAGGCGAACACCG CGATGGGTTCACCAGACTGCACAGCATCACCCAGGTGGATCTTCAGGCGCTCGTCTTTGCCGGTCAAGCCCACCTTC AGGCCGAACGACTCGGGATGAGCCATCAGCTGGCGGCAGCGAATGGCGGCAACTGCCGGCGAACCCGCCGCCAAGAA GGAGTCTTCCAGCTCGACCAGTGCGGATTCCTCCATCTTCTCGTACACCTTGCGGTGTGCCGCGCTCATGTCGCACA GTTCGGGGATGATCACCTTCGATTCCGGCCCGTGGACTTCTTCGAAGGTGTGGCGCACGGCCACGTTCATGAAGATC TGGCGCAGCTTCTCGTGATTGCGCCAGCCAGTGATCTTGCCGGTGGCGTCGTCGCGCACGCTGTGAAAGCCGAGAAA GCCGCCGTAGCTGCCATAGAAGCGCGGCTCGATGATCTGAAGCGCCGGATAGGCCGAGGACAGCCGGCCCTTGATGA TGGTCCCGGTCATGCCCAGGAACGTGTCTATCTCGCGCATCGAGTCGTACAGATGTTGGGTGCGCTTCGAGTCATGG CCAGCGAAGCCCAGGTGCATCTCATCGACCGTCAGGTGGCCCATCTGGGGATGGTGATGCAGGATCTCTTCCCAGTC ATCCGCCCAGCGGTCAAAGCCCATCAGCAAGACCTTGGCTTCCTTCTGCCGCAGGAGCTGTTCACGCTGCGCCGGAG TGCCGTCGAGGATGACCACTTCTTCTTCCCTGAAGTGGCTGAAGTCGAGGATGTCCTGGCGGTTCTTGCGCAAGAGC GACTTGGGCATGGCCCAGGTCGACTTGATGTTCTTCTCGCTGGCCAGATACCACGTATACATCGCCGCGCTGCCGGT CTTTTGCGCACCAGGGTCCGAGAGGTTCAGACAACGGCGCTGCGTCATGTAGAACGCCAGATCGGCAATCTGGTGAGGGCGGGGGGTCATGCGCATTGGATTACCTCTTGGGGGGAAGCGGGCCGAGCGGATCATCGTCTCGGCGCATGAAGCG TTTGAGTACCATCATGCCGAGGTTTTCCAGCGGCATTTGACTGAGCTTGTCGAAGTCTTCGATGGTCAAGCTCGTGC TGATCTTCTCGATGGGCTGCGTCACAATGATCTGCGACGAGCCGGTCATGATCAGCTTTCGACGGCTGGTGTAGCCG ATGTCCTTCAGGTCTTCCAGCAGGCCGTGGTGGCGAAAGCCCATCTGCGTGATGACCATGGGCTGGGCGTTGGTGCG GCCCAGCTCGGCCGGCAGGCGGTTGCTGGTGGCCACCATCCAGGCCGGGTGGACGATGGGTTCGATGGGGCTGGAGA GCCGCGACAGCGTGTACAGGGGCCGCAGCAGCTCGTTGCCGTTGTCTTCGATGAAGTACAGGCCTGGGGTGTACTGC TCCTTCGGCAGGGGCAGCATGGCCCGCACAAGGGGATCCTTGGCGTACTGGCGGAACAGCTCCCAGTGGCGCGGGTC GGGCACCGCCGCCGAGACCGGGAACATGTGATTGCAGGTCTTGAAACCCGTGGGGCGCACGCGGTAGGGCGACGGCG CACGCAGCGACAAGAAGTTCACCGCGCCGCGCCCCTGGTGAAGATACGCCACGCCAGTATCGGTCCAGTGGACGCCG TAGTAAGGGACTTCGATTTGGGTTTCCACGGTCATATTTGCACCAGTTCCGCGATTGATTTCTTCGTGTAGGTTGAG ATGTCCAGGAGATCTATCAAGGTGACATCGAAGACACCTTTCTCGATAGCAGCCAGCTTGTGTGTCGTCCAGCCGAT CTTGGCCGCCGCCTCTTGGCGGGTCTGGCGGATCTCCATGGAACGACTGAAGGCCAGTCGCTCACCCAGCTTCTCGT GGGTTCGGCTGATGGTGCTTTTCATCTTCCTTTCTTTCGGGCCGTTGGTCTTCTCCCGGTCGGAGGCTTTGATTCCA CGCGCAGCTAGGATCTTCCTGACCAATGGTTCGGAGATCTGGAACGACCTAGCGAGCGCGGGGGCCGACAATCCCGT CAGGTATCCGTCGGCCACCTGTTGGTCGCGCTCGTCCTTCGTCATACCGCTAACCAATCTTGGTGAACGGATACTTG GAAGGATTCTTCTTGATCGTTGCGGAGAAGGCGCTGCCCACCGAAGCGGAGGTGGAGAAGACGTGTTCGACGGTCGA GGGTTCGACGTTGTCGTATTCGTACACGCCACCACGGATGAACTTGATCCGCAGCTTGGACGACGAGGCGTCGTAGT GGTAGCCCGCGATTTGCGACGATTCAACGGGGGTGAAGGTGGTGGACATCTTTGATTCCTTACTGGAAATGGTGGTA GGGGTGGCGGGTATCGAACCAAATGCTCGTCAGCATCGCGCCTTCCGGTTAAGAACCGGGTGCTCTCCTTGAGCTAC ACCCCATTGAACGGTCAGCCGCGGCTGTAGAAGTTCTCGATGTCCTGGCGAGCCGGCGAGGGGCGCACGTCACGCAG AACAGCCGAGGGCTGGGTTCCTTGCGGCACGCCGTCGCTGCACAGGCCCTGGCCCTTCAGGGCGGCACGGGTCTTCT CGTCGGACTGGCACAGCACGTCGATGGCGGCGGTCTCCAGGCGCTGGGCGCGCACCGGATCTTTGGTCGTGGCGCTG GCTTGCATGATGCGCTCGAAGTTGCGGCGCAGGCTGCAATGCTCGTCCTCGACCGGCACAGCCACGTTGATGCCGAA CGCGATGGCCGAGCCGCCACCGCCGCTGGACACCATGCAGCTGTCGGGTGAGAACGAGCCGTAGAAGCCCTGGCCGG CCACGGGCGGCGCGAACTTCTGCGTGCTGGTGCCGTCGTTCTTGCTGTTGAAGTTGATGTTCTGGGCGTTGCCCGCG TTGGTCGCGCCGCTGGTGGACAGCGTGGTGGCGTTCGAGGCGGTGTTGACCGAAGTCTGGGCGGCGGCGTTGAGCGG GAACCCGGCGATCAGGGCGACGAGGGCCGCGATGCCGAAGGAGATCTTGAACATGGTGAGCACCTGTAACTAGGGGA GTTGAAAAAAGCGGGGCCATCGGCCCCGCTTGTGGTTGCAGCCGGGCGGTCAGTGGGAGCCGAAGCCGCCGATGCTG CCGGTCAGCTTGACCCCGCCGATGGCGCTGATGGCGGCGGTGCCCCAGTTGGCCGTGCCGCCCGCGTTCACCTTGGT CTGGCCGAAGGCCGCGTTGCCGTTGGCGATGCTGTCACCCACGTTGACCGGCGCGCTGCCGCTCACGGAACCGAAGC CGTAGGTGTTGGCGTACTGGCTGACGCTGGTCACGACCTGCGCGCCCTGGTGGTTCACCGTGCCGCCGATGCTGGCC GTGCCACCCGAGTTGCCACCGGCCATCTGGATCGAGCTGCCCGCGCCGTTGACCTGCGAAGCGGCCACCGCTTGGCC TTCGGAGAAGCTGCCGGCGCTGCCGGTGACGATGCCGGCCGTGATCTGGCCGCTGGCCGAGACACCGGCTTCCTTGC CGCCGTGGGCCATGGCCACCGACGAAACCACCAGACCGATGGCCAGAGCGAGCGAAGCAGAGAGGGAACGATAGGAT TTCATAATGGTAAGACTCCAGAGTTGGGAGGGTGCCAGTGGCCGACTGACGGCGGTATTACTTCAGGAACTAGATCT AGATGATCGTCCTGTTCATGACTGAAGGTTGAAGGTTACTTCTTCTTGATCGAAAGCACCAGCCCCCGCTTGAGGTC TTGAACGATTTTTCTCTGTTCCTTGGTCAAGAAGCCGCTGTCCAGCAGGTTGTTGGCCGCCGTCATCCAGGTCTTGC GGTCGACTTCCTTGGGCGGGCGCGGATCTTCGGGGTCATACGCCGCCTTGATCACGGGATGCTTGCGCAGTGCAGCA GCCGTCAACCGCAGAGTCTTGATCGCATCGTCGGCCGTCATCGGCTTGGCCGTGGTGGCTTCAGGCTGTTCTTGGAT GTCAGAGTTCACTGGGCTTCCTTTGCAAAATGGTGCGGGCCTCGCTGGGCATCGCGTGCTTGATGTTGTTCTCTTGC CCGTGCTTGAACAGCCCAACCAGCTCGGGGATGTCCGGGTGGGTGCCGAAGTACACGAACTCGGGAAGATGAGGACG GATGAGGTTGGAGATGTCCTCGAAAATCTCGCGCCCATGGGCGTTCCAGAACGGATGATCCTCACTGCGCAAGGCAG CACTCAAGCCAAAGCCGAGCCACTTGTCCTTGAGCCTGTTGATCGAGTCGATATGCACGCGAGCGAGCACGAGGATG GCGGCGTCCACCAGTTTGCAGATCGACTTGTTGTCGGCGATGAAGACCGGGCGCTCGTGGGGGAGTTCGTAAGCCAT GATCACCTCTTCTCGATCACCGCACCGGGCGGCAGCGCGTACAAGGGCGAGATCATGAAATCCTTGACCACGCCCAC CTGTTTGAAGACGGTCATGGTGGTCTTCCAACGGTCGAGCACCGTCTGCGAATCGAAGAATCGCTGACGCATACCGC CTTTGGGATAGGTGACCAGCATGACCGCCATGGTTTTGATATCAGTTGCCATTGACGATGTGTCCTTTCCCCATTTC ATGCAGGAGTTTGATGATCAATTCCCTGGGGAAGTCGATCATGTAAACATGCTCCAGAACCTCCTGAAGCGTGGCCG GCCCCCCGACTGAGAAGATCTGGTCCAGGAGATCTTGACAGTCACTTTTCAACGTGTCCTCGGGCGAGGGTGGTTGC TCATCGGAACCGGACTTCTTGTTTTCCTTGGGCAACCCCAGGACCACGAAGTCCCAATGCTCTGGGTTGCAGCACAA CGTGTTGCCGCAGCTGTTGATGACACGCCACGGCAACTCGACTTCAGAGACGCTAGGGTTCAAGTATTCATAGACCA CGCGGTTGATGATCAGATACTTGCCCTGGTACTTGATCGAACCATACGGCCTATCGATCTGCGTTCTCAAGTTGATC GGTTGCCCGAGCGAGAAGGTTCTTCGCACGCGAGTGCGCGGCTGGCTCTTCTTGCCGGTCCATGGCCAGCAGACTCC GGGGGTGCCGTAGTTCTCGATGCGCTTGATGGCTCGCTTGACCATCTTTTCGAGATCGTCTCTGTCCATGGTGGCTC CTTATTCGACGGGTTGGAAGTCGTCCAGCGGCACGAACGCATTGAGCTTCGGCGCTTCGCAGTTGTTGCACTCCAAC GTCAGGTCGAGACTGCCTTCCGGCGTGAAGTCCCCGCAATCGAGCGACAGCGGGGAGCCGCAGGCGCGGCAGCGAAT GCTGAGGGTCATGGCCATGATCGACTCCTGTCAAAAATGTGTCAGCAGGTTGTCGAAGAACTCCTGCGGGCGTTCTTCGCACTTGCCGCAGAAGGCGCGAATGTGGCGCGTGGTCGTGCTGGAGTGGCCAGTGCTGGTTCGCACATACCCGACG CCGGGCAGGAAGGCAGCGACCGGCGTCTCGTAAGAGAACAACACCTCGGTGCCATCCTTGAGGATCCGCGTGGTCGA ATTGGCCGAGTTGATCTTGATCTTCATGATCCGTTTCCTTTGTTGTCGTAGTAAGCCCTCAATGCAGCCCTGAGCAT TCGCTTGAGGACTTCGACGCTTGGGTGGTGAAAGTCTTCACTGAGCACGTCACGAGCAGCCTTCACCATTGCAGCCG TGACCGGGATTTCATCGACTCCTTCAGGCGGCGGGGGTTCGGTGTACCTGGGGGAGGGGAGGGTTTCGGTCAACTCC CCGTTTTTAAAGAAGTGAACTTCTCCCCAGCGATACGACCGCAACCAAGACATCATCTTACCGGCTCGAACTGGGTC CGAGCCGGCGTATTCCAGCTGACCTTCCTGCACGATGTGGTACTCGGATGGGCCGGTGGGGCGGCTCATCAAGTCCA TCATCGTGAGGTTCTTAGTCTTCTTCGAAGTCGTCATCATCGTCCCCTTCGAGCGCGTGGACCATGCTGGCCCGGGG AACATCACTCTGGCCTTCGTACTCGGGCGTGCCGTCTTGCACGTAGATGGCGGCGGCTTCCAGCTTCTGGCGGCCAT CCAGGATCTGCTGTTCGCGTTCCTCCCAGCGCTCCGGGTTGATCTCGTCCACGATGTGACGGCGCACCAGCGTGGAC AGGTAGCGCGGCTCCAGCGCGTCCAGCTCCCAGCTGGATTCGCCGAACTGCGAGGCGTAGGTCTCGAACCGGGCGTC GGTGGTCTTGGCCGGGTTCTCCGGCGGGTTCTGTTCCTCGACCTGTTCCATGTTCAGCGCGAGACGGCGCAGCTCGA AACGAAAGCCGGCGAACATCTCCAGGCGCTCGGTCAGGTCGCGGGTCATGTCGATGCCCGAGGGGTCATGGTCCCCC AGGTGCAGGATCAGCGAGCGTTGCCACTTCAGCGTGGTTTCAGCGAAGTCGCGCAGCACCGTGGAGGACGGGTAGCC ACGGGCAGCCAGGATCGGCACGCCGAAGCGATGGCACACGCCCTGCAAGACGCCGACGAGGGCTTCTTTCTCGATGA TGACGAACACGCGGCGTTCCTGGTTGCTCCACATGTCCATGTAGAACTGTTCGGCGCAGGCCCGGACCATGCTGGTG GGCTGTTTCCAGGTGCCGCGGCGCTGGAATTCCCGGGTCCGGTCTTCGAACCAGTCCCAGTCCAGCAGGCCGGCCAG CTTGGCCTCGTTGATCAAGTCGGCCACGCGCTTGTAGCTGCGCATGGTGTTCTCGACGTGGCCGCGAGCCACCAGCT GGTAGTAGGCCTGACGAGTCGTCAGGATCAGCCCCATGTTCGCGTATTCCTCGCCGATGTCGTGGATGATGGTGATC AGTGCCATCGATTCGGCGCGGAACTTCTTGTCTTTATAGGCTTGCTTCATTTGCAGCCGCTCCTTGCATGATTCCTT GGTCGGAAAAGAAGCCCCGGGGCTTTCACACCGGGGCTTCCTACACTGCACGGCCCGAAGGCCGAGGTCTTACTTGG CGCTGTCGCCGTCGATCTGTTTGGCCAGCACCGGGTCCAGCTTGAAGAAGGCCGACAGGTGGGTCAGCAGCGCGTTG CCGTTGGCTTCGATGTTGGCCAGCAGCTCTTCACGCGAGGCCAGCAGCTCGGTCACGGCTTCCTGGCCCGCCACGGC TTCGGTCACGATCACGCCGTTCTCTTCGACGGCGGCCGTGGCCGGCACGGCTTCCTTGAGCAGCGTGGGCTGGATGT TCGCCATCAGCAGGTCCAGGACGCGGCCCAGGCCTTGGGCGCGCAGTTGGCGGGCTTGTTCACGTTGCGCTTGCAGC TTGGCGAAGGCTTCTTCCTGGGCCGGCGACCATTCGGCCGTGGCGCGGGGAGCGCCGCGCAGGGCGCGGGGCGACTT GCCGTCGTTGCCGCCCTTGTTCTTGGGCGCGGCCGGCTGGGTGGTCGAGGCGTTGGTCTTGGCGTTGGTCTTCTTGG TCGAGTCGGTAGCAGGAGTCGTCATGATGCAAAGTTCCTCTAGAGGGAAGGTGGAGAAAGAAAATAGCCTTTCGGCT GGGGGAATTGCCTGCGCTTATTGGTTCTGAGCGCGGGCGTAGTTGGTAACCAGGCCGATGTCGATCATCGCGTCCAG GGCGCGGCCGGCGGCCGCGTGGCTGAAGGAGCCGGACGGGCTGTTCATGGCGCGATGGATGCGGGCGATGGCGCTGG CGCGGTTCACGGGGCCGCCATGACCCTTTTCCAGCAGCACCTGTTCGGAGCCGACCGATTGCAGCGCGGCCTGCGGG CCGAGCGCGGCGATGACGCTGTTGGCGTTGGACAGCAACAGGCTGATCACGGAGTCCACCGGCACGGGCTTGGAGAT CAAGTCCGGGCACAGGCCTTTGATCAGCAGCGACGACAGCGCGTTGTAGCGGCGCTCGCGCTCCAGGGCGGCTTGGG TTTCGGCGTATTGCTTGCGGGCCACCATGTTTTCCAGGTGGCGCTCGTCTTCAGCGGACCAGAGGGGGTTGTTCATG TTCTTCGGTTCCAGTTCCGCTGTTGTTGTAGTCGTAGACCCAATCAGGATCAAACTGAACGTTCTGAAGAAGACGAC GAAATTCAAGGAAGAAGGTTTGAAGATCCTTCTTGATCCTTTTCTTAATCTCCAAGGCCATGCGGTCGGCTGTCGTC GCCACGCGCAGGTTCACTTGATCCATCACACGGTTCTGGATCTGTACCTTGAGCGAGGCGATGGCTTCGGCGGGAGT CATTGAGTACCCGGCTTTGCTTGGCAGTAGAAGAGACCGTTATCTTCACGAACCTCCATGATCTGATGATCCCCGAG CACGTCGCCGACTTCCAACGGTGTGCTGGTGATGATGCGGTAGGCAGAAGAGTCAAACTTCAGCACGTCAGTGGTCG GGTTGCGACTCTCGACGTTGAAGTACACGGTCGGAACCACGACCACCAAGCCTCCACTGACTTTCAGCTTGGTGACC GGATGGATGGTCATTTCCTTGCGCTTCAGGCTGGCCTGAAACGGCGTGTGGAACATGCGGAACACGTTGTCGCGTTC CGTGATGTTGAAATAGGCCAGCGTGTAGTATTCGCCGCGATCCAGGATCACATCTCCGGCCTGGCATACCGATGACC TCGGAGTCCTCATCATCCTCATGACCGACTCAAACGCTTCGGTAGCGGAGCGGGCCTGGGGAGCCGAGGTGACGCAA GGAACCCTTGCGTTACCTCGACTCAGGTTGACGACGATGCGAGTCAGATTGGTGGGACGGCTCATTGGTTGGTCACC GGATCAGTGGGCGAAGAGACCAGGAACAACGTGGGGTACAGCTCGGTCACATCACCAACAACACCAATATCAACAAG AATTTCGCCCAGCCGAGTTTGGAGGTCGGCAATAAGGCGGTCCCAGTCGATTCCACGAAACCGAGTGAACATGGCGT TTTCATCTTGTCGGGTCTGGAAGGTTCGAAGTTGAAGAGAAGGGATAACCATCAAGGCCGCCGTTATGGCGACCGCT TGGTTGGCCCCGTTGCGAATACTGGTAGCCCCGCTCTTCATCGCATTTTCGAAAGGCGAGGCATAGCGCGACTTCAG GTCATAGTAGGCGCTCAACGTATCAACGTCAGCGTCCGGCAGTTCTTCGGCGCTGACGCCGAGCACGGCTCGAACCA TGCTCGGGTCAGCTTCAATGCCGATGAAGGGGGTGACGCCGATAGTGACTCGCTGTTGACGAATAGACCCATCCCAG TAAAACCGGATGATGATGTGGCGCGCTTCGGTCTCATTTCCCAGGTTGAGGGTCATGTCGGTGCCAGACAGCGCGAT AGGCACCGAGGTGCCCGTCATCGTCACCTCTCGGGCAGGACTTCCGATGATGTTACCGGCTTGATCCCGCACGTAGA GGGTTGCCTTTCCGTCGTCAGAAACAACGGGCACCTCGTCCACCGTGGCCTGCACGTTGAACGAGATGGCTTCGTCA GCGAATCCCCACAGCATCGTGGTCTCCCTTAAGCGCGACGGCGGGGCGTCGACTTGTCCGCCGCTTTATCGGCGGTG CCAGCCTTGTCGGCCTCTTCCTGCGCCTTAGCCGCAGCAGCAGCGGCCTCTTCCTCTTCAGCCTTGGCCTTGGCAGC GGCCTCTTCCTGCGCCTTGGCAGCGGCCTCTTCCTGCGCCTTGGCAGCGGCCTTGTCGGCCTCTTCCTGCGCCTTGG CATCGGCTTCTTCCTGGGCCTTGGCAGCGGCCTTGTCGGCCTCTTCCTGGGCCTGCGCGGCGGCCTTCTGGGCGTCCTCGGTGTTGTCCGGGGCACCTTCGCTCCACACGCTCAGGAACGAGTTCATGGCCAAGTCCTCGTTATTGCCCGAGTC CTTGAAAAACTTGGCCAGCTCGGCGTCCGTGGCGTCATCCTTCAGATCGATGGGGAAGACCTCGATCTGCGGCGCAA CGGGCGGCGTCGTCTGGCCGGCGCGGTGCCGGATGAAGTGGGTGTTGTGGACCACGTAGGGGCGCTTGTTGTCCACG TAGTCTCCGGTGGACGGGTCCACCAGCATGATCGAAGACAGGGCTTTGACGAGCAGTTTATGTTTCATGGCTTGAAG CTCCTATGGGTGAAGTAAAAAGGCCCGCCCGAACTCGGGCGGGCCTTTTCTGCCTATGGCGCGGATCGCTTAAGCGG TCGTGTCCAGGACCGAGCGCGTGTCGCCGAACACCAGACGGTAGCCGGTGTTTTCCGAGCGAACGTAGGTGATCGCT TGGTTGACGATGGAACGCTCGTTTTCCGAGATGTTCGAACCGGCTTCCAGCAGCTCTTCCAGCGTCTCGGCCTTGGT GTAGCCGACGAGCTTGCCTTCGGGCACCGTGGACGACAGGTGGAAGTTGACCGACTGGTTCAGCAGCGGCAGGTTGG TGTTGATCTTCGGCGTGCCCGCGGCAACCAGCTTTTCGATGTCGGTCGTGGTGCCGTACAGCGTGGGCTGGAACATG AACAGCAGGTCGATGAAGATGTCGTAGTTGCCGATGATCGTGTCGATCGGGCGACCGTTCTTGGCGGCGTCCATCAA CCACTTGGCCAGGGCCTTGTAGTTCTTGGACAGACCGTCAGCCGGCGTGCCGTCGAACGCCGAGATGCCCACCACGG GAGCCGCGCCGTTCACGCCGTCGCCGTTGATCAGGATCGAGGTCGCGGCGCGCACCTTGGAGATTTCCAGCTCGCGG GCCACACGGGCGGCGAACGGGGTCATGATGTCCAGGCTGGCGCGGCGGTTGAACTCGTAGCTGGTACGGTAGCCCGA GCCGTGCTTGAACATGCCGACGGCCTGTTGCGTGGTGCGCAGCGAGCGAACCGGGATGCGGCCCAGTTCCGACACGG TGTAGGTGCCGCGTTGGTCGGAGTCGTCTTCCACGAAGGTCGAGATCATCTCGGCACCGTTGATGGTGCGCGATTGG GCGATCAGCGGGCCGACGGTTTCCAGCTGGTCCTGGCGGTTCTTCCAGCGCAGCACGTCATCCATGACTTCCGGGAA CATGGCGCGGGTGCCCGGGTAGGTCTGGAAGGTTTCGCTGGCCGCTTGCAGGATGACGCCCTGTTCCAGGTCGTTCT TGACCGGCAGGTTCAGGCAGGCCAGGGAGGCCTCGTAGCCGTTCAGGCCTTCGTACTTGCGGGCGTCGTCGGCCTTG GACAGGCGCGGGTCGATGGCCAGGGTCAGGTAGTCGCGCAGGTTCAGACCCACGTCCTTGGCGCGAGCGACCAGTTT CTGGCCGGCGGCGATGGATTCGCTGGTGCTGTCGGCCTTCAGGCCAGCCAGGGCATCTTCCGGTGCCTGACGCTTGA TGTCGATGAGATCCATGTTATGTCCCTAGAGATCTGTGTGAGGTTGTGGGGTTTGGTTGGATCGCTGTGTTTACAGC TTCAGCAGCACCACTTGCGTGGGCGACAGCTTCTGGACGCACTTCCAGCGATGCACGCCAGCGTCACCCGCCAGGGC CTTGCGCACGGTGCCCGCGCCGCCGCCGCAGGCGCGGTCGCCAGGAGCCAGCGTATCGCCGCTCTTGAGCGGGAAGA TCACGCCGCCGTTGGAGTTGACGGTGCCGACCTTGATGCCTTCTTGCACGCGGTCTTCCACGACTTCCAGGCGACCA TCGATCTCGGCGCCGTCAGCGGACAGCGAGACGAGGTTTTCGGCCGTGACCGTCACCGCCTTGGCGATGTCGCTCTT GGTGATGGCCGAGTTCAGCAGGAACGTGTATTGCGAGTCTTCGTGGAAGTGACCGCTGAGGGTAACGCCTTGACCGA TCTGCATTGTGTTCTCCAGTAATCGGTGGGTTGATGATTAACGACGCGCCGACTTGAACGCGCTGTTGCCCGCCGAA GCGGAGAGGTCCGCCACGCCATCACGGCCCGGCTCGGAACGCGGTTTGCCCACCACGCCGGCCTTGAGCACTTCGAC CTGGGCGGTGGCGGCGGTCAGCTTGGTTTCCAGCTCGGCCTTGGCCGTGTTGGCGGTGGCCAGCTCGGCCTTGGTGG CTTCATGCGCGGTGTTGGCGGCAGTCAGCTCGGCCTTGGCGGCTTCCAGCTCGGTCTTGACGGCGGTGACGGCTTCG CCCGACTTCAGTTGATCGCGCTCGGCAGTCAGCGTGGCGACTTGCGCCTTCAGCGATTCGGTTTCAGCGGTCAAGGT GACCACGGAGGCCTTCAGCGTGGCTTCGCTCGCGCTCAAGGCCGAGAGTTTTTCGATCAGTTCTTTGTCCATGGTAT TGGAACTCCGGGGGTGGTCTTTGGTTGTGGCGAAAAGGAAGGTGGCTTCGGGAGTGATCCCGCTGGCGGCCAGTTTC TCGTAACGCTCGGAACCCAGGCGCTGTTTGGAGCGGCTGAGGATCTTGGCGTTGTTCGAGGCACCCTTGGACACGAG CGAGGTTTCGGTCCACGCCTCCATGCCGTTGAGGTTCAGGTGAACACCGTTCTGGCCCATGACGTGATCATTTCCAC ACGTCTGGTCGATCAGGTTCATGATCGTGGCGTCGTCGCCGAGGAAATCCCAGCCGCACTCCGAACACAGCATCATC TTCGAACGGAGTCCGATGGACACCTCGTCAATGATGCCGGTTTCCATCTTTTCGATCTTGTCCGTCTCGCTCGCCGA GATGTAGAACTGGGTCACCAGATCCATCGACCCGTCGTTGAGCGGGGAAGGCAGCACCTCCGCGTAGAAGAAGCGGC CCAGCGGCAACTCATCCCCTTCCGGGTGGAGGGTATGAAGAGGCACGAAGCCCTTCTGATCGTTCAGATAAGACGCC ATTTCCATCAGCGTCGAGACCGAGATCCGGCCTTTGTCGAAGATGGAACCACGCTTGTTGATCGGCCGGTTGGAAGC GGCCACGCACTCGAACGCCACGATCTTGCTCAGATCGAGGGCGTCACCTCCGTTGTTCGCCTTGATGCGCGCTTCAA CGGCGGGGGTGATTTCTATGCTCTTGGCCATACCAGTCTGGTGAGTAAATTGAGCTGCGGTGAAGTGCCGGTATTAT TTCGGCACCCCATGTTTAAGTCAAAGAGTTTTTACTTCTTGGTGCTTGATGGTTGCGTCTTGACCGTGTTGCTTCGC ACCGACTTGCCACCCGGCGGGGCCAACGACTTGCCCATCGGATCGGCGTTGGGGCTGACGTTCTCGACGTCGATGCC ACTGCCCACCGCGCCGCCGCCGGCCAGGAAGTTCGTGCCGGACAGCTCCGGCGCGGAGTCCGGCCGCAGCCGGCCGT ACATCTGAAGGTGATACTCGTCGTCGCTGATGATGCCCAGCGACAGATCTTCCTTGAGACGGGCGGCGCGCATGGTG TATTGCGGTTCCAGTTCGGTATCAGGACGCATCTCGGAGGGACGGAAAGTCACCTCAACCCGAGAGGCCGAACCTTG CAGGCGGATGGCCAGCGTGAGCGCGCTGGACATCAGATCAGCGATGGGTCGGTTCAGCTCTTCCGCGTTCATGGTGA ACAGGCGCGCTTCGACCGTCGCGGTGTTCACCCCGGAGTTGCCGCGGCCCAGGATGGTGGCCATCGTGCGCATACCA GCCTGGTTCTGCGCGTTCAGCGTCTCGATCACCTTGCTGATGTCGACGGCCATGCCAGGGGACTTCTCGTTCAGGAT GCCCACGTCGACCGAATCGGTATGCACGAAGGCTTGATCTACCCGGATGTTGGAGACCGCCGACGAGATGGTGCGCA TCTGGGCCTCGACGTAGGCCCGCAGCTTTTCCTGGTCCATCCGGATTTCAGTCGGCGCTTTCTTCTGGATGACCTCT TCCAGCACCGTGACTTCCATGCGCGGGTAGCCCGTGACCTGCATGATGCGGTACAGGTCGTTGATGACCTGCTGGCG CGCCGCGATGGTGTTGATGGACGACACGAAGGACGAGTAGGTGTACATCGTCGTCGGATCGCGGCGGTGGAACTTCA CGAAGAAGGTGGGAATGTCGAGCACGATGGTCTTGCCATCGCTCGTTTTCTGCTGGGGCTTGAAAACGCCGGGTTGA GGCTCGACCCACTCCAGCGTGTCCGGGTCGACCATGCGGAACTCGGTGATCGAGAAGTTCTCATCGAACACAGTCTC CACCGGCAGCGCGCCACAGCGCAGCAGCAGGTATCGGAAGTTCTCGCAGATCTCGTTGAGCGAGGGGCGCAGCTGGAACCCTTTCGAGTAGTCGCTGCGTTGCTCGAAGGCCTGCAAGATCGCGTTCAGGATCTTCTGACCTTCACGGTCGATG GCACCATCAACGTCCTTAACCAGGGGCAGCATCTCCGTGTTGGCCATGGTCAAGTAGGCGTTGACCGCCGCCGACAT GTCGGGGTCTTGGATGAACAGGGTCTTAATCAGTTCCCGCGAGTTCGACGCCGAACGACTGGTGAAGATGTCGCTCA GGTGATCTCGATACCCAGGGACCGTCAGCGTCTGACTGGGGTCGCTCGGGTTGTAGTGACCAGGGATGGCCGTGCCG GCCTTATTCGCACGCTTGGGCAGCACCAGCTGCTGAAGCTTGGAGATAAGGCCCCCGCCTTTAGACGAAGAGGATGT TTGCTTGGTTGCCATGGTTCACTTTCTTCGAAGCCTGCCCGAGCGGCAGGAAGATATTGGAATTGGGTGAAGACTGC GCGAAGGATACCCCAGCCACCGACACAGTGGAACGAGTCTCTGGCGCTTCCTTGGATCCGACGCCTTCCATCCTGAT CTTGACGGCGGTCACCATGAAGCCCAGGGCGTGGAAGTAGTGGTCGTTGTTGCTCAGTTTTCGCCACGTTGCTTCGG TCTCAGGAGTTTCCTCGCGCACCATGTCCCGGAAGTGCTCGGTAATGGTGTTTTTCTGGGTGCCGTAGCCTGAAAAG CGGATCTTTGCCTGCCTAACGAGACGTGCGACATCATCAAGGAGAATGGTCCGGTTGGCTTGCGCATACAGTTCATT GCCTCCAGCGTCCTTGACGATGTTGACTTCCTTCTGACCGCGGTACTCGATGGGCAAGATGAGACCATGGGTCTGGT CCCGGGCCGCGTCGGCCGTCGGCGTGTAGGGGTGGCGGTCGCAGCCCCCGCCAAACAGCCGGTAGGTGTTCTTGAGG CGTTCGAGCACCGAGGGCAGCTGGTCGACCGGGCAGGCGATGAACTCCCGGACCTCCAGGTCCATGAGACCGAAGCC CTGGGCCACCACGATGTGCGCCGTCTGGCCCATGTCGATGCCTATCCAGGCCGGCACGCCCAGCAGGGGCGGCTTGA CCAGCATCTCGTGGGTGAAGCAAGCATGGATGACGGGCACCGACAGGCGTTCGTTGCCGCCCTCGTTGGCCTGCCCG AGCACGGTGTTGTGCCAGCCGCGCAGGTTGTCGAACTGTTTGTACTTGAACAGCTGCTGCACCACGTACTGGGGCGT CAGGCGCTCGGTGGAGAAGGTGCGCACGCGGTAGCCACGCGAGTGCGTGCGGTTCGGGTACTTGGCCACCCACTGGC GGCGGGCGTGGTCGCCGACGTTGATCCTCTTGTGGCACTTCTCGCACATGATGTACATGCCGAGGAAGTCGATCTTG CCCTCATCGAGCATGTCAGGTTCCAGCTCTTCGAAGTCCATGCTGTCTGGCATACCATCCAGGCGCACGAAATTACG ACTGAAGAGCGGGACTTGTTGATGGTTGCAGTGCTCGCACTTGTAGAAATACTCGTGCTGATCGCTGTTGTTGTAGA GTTGATCTATGCCGTAGCCTTCGAAGGTCGGCGTGGAAAACTTGTGGTTCAGACCCCAGTCCGAACCTTGCAAACGC GAGTTGAACAAGCCCAGCATGGCCTGATCAGTCAAGTCCACTTCGTCATTGGCCACCATGTCGGCGGTCGTCGCGGT CGCATCGCTCTCACCCGCGCCGGTGATGTACATGAAGGAGCGACCTACCTGGATGATGCTCTTGGAGCGGGTCGGCT TACCCGAGTTGCCCACCTGTTCGAGGTTGAACACCTTGTCGTTGTCCACGATGGGCCGGATACGGCCCGTCGAGATC TTCTCGAACATCTTCTCGTTGGGCAACGTGTAGATGACGTTCACGCCCTTGTATCGAGCGATGAAAGCGAGCACCTT GCGGATCTGAATCTCGGTCAAGCCCACCTGCGACGGCTTGATGACGTTCAAATCCTTGCTCATGTCATCGGCGATTT GCTTCTGGAAAGGATAGCGATTGAAGTTGAAAGGCTGATCGTTCAACCTCGTGTTGGCCATCATCCAGTCGCCGGCC GTCATGCCTTCTCGATCCGTCGAATAACGGTTCGAGCAGCGGTCGAGGAACGATTCGATGTAGTGGTTGCTCATGAT GGGTCTGGTTATCTAGGACGCTATTCTCACCCAGGTCTGGGGTGTGGCACAAAGGAAACCTGAAGATCCATGCTTTA TCGTATAAAGACCACGTTGTATCCGATACCCGGGTGGGATTTATCGTATAAACGATAGATTTTCATTCATTGAATCT TGCCGGTGTGGGAAGATGCCGTCCTCCCCTTCCGAAGAGCAAGAAATGAGCTACCACTATCCTGACCTGGGCGAAAA GGCGGAATGGGCCTTGGGCATCATTGCCACCCTCGGCACCGAAAACGCGGACTACTTCACCTCGCCTGACTGCCCCT ATGAAGGCCAGACCAAGGTGCTGCTCCAGGCCATGTGCCGGGCCGCGGCAACCGAGCCGCCCAAGACCTCGGCTGCG CCTTCCAGCCCCATCACCGATGACGATCTGGCCAAGATCGACACCACGCTGGAGGCCGATCTGCTGCTCGTGCTGCG CGAGCTGAAGACCTACGGCAACACGCTGACCAACGCGGACCAGACCGAGAAGATGTCTTACTTTCGCACCATCACCA GCCTGCTCGAAAAGCTGGTCATGCTGCGCGAGCGCGCCGTCGGGGTCAAGCAAGTCAAGGAATTTGAAAACGCGGTG CTTGGCGTGATGGAAGAAACCCTCACGCCCGAGCAACGCACACAAGTAATGGATGGACTTCGATCCATCCTGTCCAA AGGGCGTCATGAACCCGTCGATCTCTCTACGGTGGATGAATAAAAATGTCAACTCAACACAATATCTTTGCTCAGAC AGCGCCGGCCTACTATGCGCGAAACCTCCCGGTCATCCCGCTCTATCCGCAAGAGAAGAAGCCGGTGCCGATGGATT GGTCGCGTTACCACGACAAGCCTGTTGAACCGGACTACCAACAGCAGTGGATCCACGGGAACCCCAACTCGAACATC GGTATCGTGCTCGGGGCTCAATCTGGCATTGTCGCGCTCGATATTGACGCCGTTGACGAGAAGTTGATCCGCATCAT CACCAGCATCTTGCCGCCTTCGCCGTGGGTTCGTATCGGTGCCAAGGGCATGGTGCTGGCCTATCGCTTCACGGGCA CGCCCACGTTCCGCATCAAGAACACGAGCGGCGACACGATCTGCGAACACCTGTCCAGTCGCACGCAGATCGTGCTG CCTCCGTCGATCCACCCGGATACCAAGCGTCCTTACACGGCCAACGTCGAGCTGCTGGACGTGATCGACAGCCTGCC GGCGCTGGACCCCAACATCGAAGCCATCCTGCGTTCGGCGCTGTCCGAGGCAGGGTGCGAATTGTCGCACACGGGTT GGACCAAGACGCTGGACTATGCGTCGGCCGGCTCGCGGGACACCACCTTGACCGAGCGCGCTGGCCTCTTTGCCTAC GCTGTGATGCGCGGTGATCGCACGCTCAAGGAAGCCATCGGTATGTTGCGGGCCTACGCCGTCGAGTTCGTGGAGAA CGTCGCTGGTGACCCCGTGGACGTGGAAAAGCACGTCTCCAACCTCATCAAGTTCCTTCACCGCGATGTGATCGACA AGCAAAAGCCGCTGCCTTCTGGTTGGGACGCCGATATGACGCCCGAAGAGAAGAAGGCGTATGGCGTCGAGTTCGAA AAGGACCATGAAGAGTGGTCCTACGACTACATTGTCGAGTTCCTGAAGGATGAATTCGAGCGGTTTCCGAAGGAAAG CCCGCAGCGTGTGCTCTCGATTGACAAGGCGCTGGCCAAGATCGCGGCTTCCAAGACGCTCAATCGCCTGGAAGAAG ACCGGCTCTTTGACTATATCGCCTCGGCCGGCCAGCTCGGCATGAAGGTTGCCTCTTTGAAGGCCCGCGTCAAGGAC TTGAGAAAGGGTGCGTTGAAGGGTGAGGACCAGTCGGAGCTGGCTCGTGCGCTCATCGCTGACCTGGAACTCATCCA TCCGGTGCGCCACCACAATGGCATGGTCTGGAAGTGGGCTGGATCGCACTGGGAAACGCTGGATGATCAAGCCATCA TGGCCAAGATCTCGACGGAATATGGCCATTTGCAGGCCTGCCGCAAGCACTCGGACATGAAAGGCATCTTGAACATC ATGAAGATGCTGCTGCCGCAGAACATCAAGTCGGTTGAGGTCAAAGGCGTGAACTTCGCCAACGGGTTCTTGACCGA AAACCTCGCGCTTTTGACGCATGATCCGCAGTTCGGCATGACTTACACGCTGCCGTTCCGCTATCTGCCGGAAAAGGCCACGGATGCGCCCATGTTCTTCGAATTCCTGGCGCGCAGCTGGGGAGAAGACGAGGACTACCAGGAAAAGGTCTTG GCGCTCCAGGAAGCCCTGTGCGTGACGCTTTTTGCTGTGGCTCCGCGTTACCAAAGGGCAATTCTGTTGCAAGGTGC GCCGAAATCGGGCAAATCCCAGATGCTCAAGATCGCATCTGCACTGGTTCCGGACTCGGCGCGCTGCGCCGCGCCGC CTGATATGTGGCATGACAAGTTCATTCGACGCTACAACAAGCTGGCGCTGGTCCATATCGTTGCGCTGGCCACGAGC CAGTTTGGCTCGATCCCGGACTTCTCCGGCGTCTATGATGGCCGGCTGGTCCAGATCCCGACCAACTACAACCCTGA TCTCCACATCTACGACGAGCTGGTTCCGTGGAACGGCACGTTCAAGACCGGCTGGACGAACAACCCGGCCTGGGTGC TGTGGGATCTGATCATGAACGTCGACTATGGTCTGCGGAAGTATTACCCGCACATCACGGCGAATCGTTATGACTTC TACGAGGCCGCCAAGTGGTGCGACGTGTCGGTCCCTGATGGCCGAGGTGGCTACCAGCCCCGCTACACCATGAACAT CGCGCTCACCGAGGCCAAGAATGGCCTGGAGATGCTGCAATACATCGCGGGCAGCTTCGGAGCTGTCATCTTCGATG ATGCGACTGGCCAGATCTACCTGCGTGTGGATAAGTGGGAAGAGCCGAAGATGCTCTTCACGCCGGAGAACGTCGAG AACGGAGAGTTCAACTACAGCTTCACGGACCTGACCACTCGCTACAACGACATCAAGGTTCAGTTCATCAACCCCGA GCTGGACTGGAACACCGACCAGCGGCGCGTGAAGTCCGATCAGCACATCGCGGCCTACGGCAACATCGACACCGAGA TGGTCATGGTCGGATGTACGAATGAGCACGAGGCCCTGCGGCGTGGCTACTACCGCTTGATCACGGCCACGACCGAG GTTGCGTCGGTGACGTTCACCACGGCCCGCCTGGGCAAGGTGGTGGATCCGTACACCATCGTGGCCATCGCGGACCC GACCCCTGGGTGGTCATTCCCTGGCCGCATCAAGCGCTACTACAACAGCTATATCGAGCTGCGAGATCCCATCTATT TCCTGGCTCGGCAGAACTACACGCTGTCGCTTCAGACTGTAGATGGAATCATCAAGGTAGTGATCGATCCCGAACAA GTCGGCGTCGTCTATCGCCTCAAAGTGGTCTCCGGCTACGTGCCTGATGGCCTGCCTGATCGCACCGTCTTCACCAT CGAGGACAACGGCAACTTCGGCGTGGCCAAGCCCTTTCGCATCGTGGACTGGGAAGCCGTTGACGGAAGCCCGGACA AGTACCGCTTCACGGCGGTCGAGGTCAACCGCAACAAGCAAAGCGGCGCGGACAACTGCACCCCGGTGGGCAGTGTG CAGTATTCGTTCAAGAACCCGCTGATCCCGCCGCCTCCGTTGAATCTGCGGGCCGAGTCTGGCACCGAGTACCTGAT GATCTCGCAAGATGGATCCTTGACGGCTCGCATCTTCGCCTATTGGGAGGCCCCGCCCAACGTGCTCATCGAGCGCT ACGAGATCAACTGGAAGGAGAGCCGGCAATCGGTCTGGAACTCGGCCAGCAGCCCGGCCGAGAGCGTGCTGCTGGGG CCTTGCAAGAGCGGCGTGGCCTACGACATCGTGGTGTGGGCCGTGAACTCGTTCGGCAACCGCTCGGCGGCGCTGAC GCTGTTCAACTACGTTTGCGTGGGCAAGAACGACCCGCCCTCGAACGTGAAGAACTTCACCATCCGTCGCCGCACCA ACGACATCTTGTTGCGCTGGGACGCGATCCCCGACCTTGACCGGCAGGGCTACGAGATCCGCCTGGGCACCACCTGG GAGACGGCGACCGTGCTGGTCACGGACTACGCGGCTACCCAGTTCGCCTGGACCACCACGGAAGGCGGCAGCTACAC CTTCCTGATCCGGGCCATCGACTCGTCTGGCAACTTCTCGCTGCTGCCCACGGCACAGTCGATCTACATCCAAGGCC CCAGCGCGGTCACAGGTGTCATTGCCATTCAGTCGAACAACCGCATCGAGCTGCGCTGGTCTCCGAACCCGGAAGAC AACATCCTGGAGTACGAGATCCGCGAGGGCTTCTCGTGGGGCACGGGCGTGTTCCTGGCCAAGGTGAAGTCCACCAG CTACAGCATGACGGCCGGCTCGTCTGGTACGCGGATGTTCTGGATCAAGGCCATCGCCTCGCCTGGGGTGTACTCGG AACGAGCGACGTTCGTCACCACGGATATTGCCCAGCTGGACAACACCAACTTGATCTACACCACCGACGAGGTGGCC AACGGCTTCCAGGGCACCCGGTACAACATGGTGGTCACTGGCGATACGCTGCGGATGGACGATGGGCGCTCCCACGC CGAGTACATCTTCCCCATCCTGCTGCCTACGGTCTTCCGCGCCCAGAACACGCTGTTCGTCGGCCTGGATGCCCTCG TGGACCAGAGCACCCGCTGGCAAGATGCGACCTACCCGTGGAACGACATCCGCGCCCAATCGCCGTGGACCATCCCT GGCGACATCTCGTCCATCGGCTACAAGGCCGAGATCGCGGTGCGCAAGGGCTTCCCGGACAATGTGCGGCACTCGAT CACCTTCAACGGCACGCTGGTCAGCGAAGGCCCGGTGGCCTACAACCCAGCGGCGATCTTGTCCCAGGTGAACGTGA CCTACGCCACTGGCAAGTTCGGCCGCGGGCTGTACGTGCGCGGCGGGGCCACCACGGCTCCCGAAGATCAAACCGAC GTGACGCTGGCCACCACGTTGCCGGCGGTCTTTACGGTCGGCGGCTGGTTCCGCATCCTGAGCGACGAGACGCAGAC CTTGACCTCGATCAACAGCGCGAGCGGCACCCATCAGTTGGTGTACTCGGTGGAGCGAGAAGCCATCGTCTGGATGG GAGCCGATGGGTTGAATGTCTCTGTCCCGTTCAAGGCAAACACCGGGGATCGATACTTCGTCACGGTGGTTCAAGAC ACTGCCAACCGGCGCTTGTACGTGGCCAGGGAAGATAAGACCTTTGTGCGAGCTGAGATATCCGCCGCTCCTTTCGA ATCCCCGACTCAACTGAGGTTCAAGGCATGAGTTTCACTGTCTCCGATGTCTTCACTAGCGCTCAAGCTTTGACCTT GTCGGACTATCTGAACATGGTGAATCATCAAGCGCCGGTCGGCTTCAGCCCCTTCCAGCAGTTTGTGGCGGGGGACT ATGAATACGACAAGGCGCTGTATCGAATCTCCATGCAGTCATCTTCGGGGGATCGAGGCATCATCACCAAGTTGCAA GTCGACGTGGACGTGCCAGACATGATGGACCGTGGTCGAGTGACGATCACGCCGGCTGAAGCTGCGGCGGGACTGAA GTATGTCGCCTTCACCCGTCCGTTCCACGTTCCTCCGATACCTGTTGCCACGCTCATGAGCGCTTCATACAACTGCG TGGTCACGATCCCCCAGGAATTCGTGACACGCACGGGCTTCATGGTCTCATTGGAACGCACCGATGGTGGTGGCCGT ACTGATGGGGTCTTCACCTGGGCGGCGCACTCGTATTAAACCTGGGCTTTGTCAAGGCTCCCGGATAAAATCGCATC ATTGATCGACGGAAGAATTCAACATGCAAAGCTATACCCAAATACCGGAGACCCAGCGGGTATCGGACTCGTTGCCG ATGCTGCTGAACAACGATCTGACGGCCATCTCGCGCAACAGCGGCACGGCCTTTCCGACCGTGGGTCTTCAGGTCGG TATGCCGTTCCTGCATCTGACGGAGCGCAAGCTGTATCGCCTGGATAGCCTGTCGCCGATCACCTGGACGCTGGAGA TCGACCTGACCCGCCAGCTCGTCTACAACGATACGGTGACCACGCTCCAGGCCGACATCAACACCAAGGTGCCGCTG TCCGGCGGGGTCATGACCGGGCTTCTCACCCTGTCTGGCAACCCCACCAACCTGATGCACGCCGCGCCTCGGGGCTA CGTCGACACCGCCATGGCCACCGCCTCGGCCTCGGCCAACACCCGGGTGCTGCGCACGGGCGACACCATGACTGGTC CTTTGACCTTGCCTGGAGATCCTACCTTGGATCTTCATGCTGCGACTAAGCGCTACGCGGACTATCTGTACAACTTG TCCAACCAGAACAAGGTGGGCAAGAGCGGCGACACCGTGGCCGAGATCTACAACACGGGCTGGTATCGCTCCGTCGG GGCCACTGGCTGGTACAACCAGACCTACGGCGGTGGCATCACGATGCAGGATGGTTCCTGGGTTCGAGTCTATGGGAGCAAGGGGTTCTTGACCGACTGGCATCAGCTGATCTCGGGCGGTCAGATCTGGACCTCGCGTTACGGCTATCTGGAA AACTACTTCGCACTCAAGGGCGCGGAAGATCGTGTCACCGCCGCTGGCACCACGGAGTCGGGCGCGGGCAACTTCTA CAGCCCCGGGGCCTACTATCTCACGCGCTCGGGCGCGACCATCTACCTCGTCAAGCCGCGGGTCAACTGCAACTGCG ATTGCAACTGCTCGTGCTTCCCGGCCGGCACCCTGGTGCTGATGGCCGACGGTACGCAAAAGCCCATCGAGACCGTG CAGGTTGGCGATCTCGTCATGGCCTGGGACGGCTCGGCCGATGAGGTCGTGGAGATGGAGACCCCCATCCTGGGGGA TCGCCGCCTGATGCGCCTGACCGATGGTTCGCTCTCGTGGTCTGAAGAACACCTGCTGTGGACGCGGCGCGACGGCA AACAGTGGTGGGGCTGCGCCAACCGCAACCAGTGGTATTCCGAGGTGCTGGTCGATCACATCAAGGGCTTGCCCGAC AACTACTCGCTGCGCGATATCGGCGACGAGGAAGAGCTGGCCCACATCTCAGGGTGGGTCAAACGCGGCGTGGTCGG CCAACAGGAAGACCCCAACACCCAGCTGTATCTGCCGCGCACCAAGCGCACCCACATGATCATCGTCAACGGCTATC TGGCCGGCGCGGGCGTTGACGGCTTCTCGATGGACTACAACCAAGTGAACTGGACGGGGATCTCCCATGTTGCTGCA TAAATCTTTCGTGGACCCCCAGCTGGCGCTCTCGCAAGATACGGAAGAGGCCAAGAAGTGGGCGTTGACCGTTCGTA TTCAGCCGACGCCCACTGGGTTCATCATGTCGTCCACTGAATACTCCCTCTACTGGCAGTTCGACTTTCGCAAGCTC CAGCATGGCAATGACATGATGTACGTCGTGCAGGATCGAGGCCGCGCCGTGAAGTTCATCTGGAAGTCCGAGTTCGC CAACTCGAAAGACGGGCTGGCCGCCGCGCTCCAGCGCAACAACGTCGATGCCTTCGCTCCGCTGGTCGTGATCGCGG TTGGCGAGTTGACTGGTCAGTGGGCGGCGCTCTTCATGACCAACACCACGCAGACGGCCGGCGAGTTCGTCAAGCTG GATGCCAAGTACGAGCGGATGCGCAGCGACCAGATCTTGTCCGAGATGGTCCCCAGCATGGCCCCCATGATCAAGGC CTATGACGACAAGCTGGTGCTGCTGCGGAACATCCGCACCAACGATTCCATCGCGGCGCTCGAAGCCCAGGTCGATC TGCTGACCACCTGGGTGGCCGCCTTGATCCCGGAGGAATACCGGGACCAGCTCCTGGAGGTCATAGCTTCAAGGAAT AAAGATACCAAAGTGGTTTTTGATGATATGCTTGCGTTCAAGAAGCGCCTGCGCGAACTGGTGGGCGCATACCAGAG CAAGAAGCCGTCATGACCACCTTCGTTCTCAAGACGGTCGACGCCAATGGTGTCGGCCGTGATTTTTTGTACAACAA CATGGCCAGTGTCCTGCGGGACTACGCCACGAGCAACAAGCTGCTGCCGGGCGTGACGCAGGAGTCGGTGCGCCCCA CCCGGCCGGCCACCCCGACCTGGACCAAGAGCCGCGAGGTGAGCGTGCTCAAGATCCAGCTGGGCCTGTCCTGCAAC TACTCCTGCGAATACTGCCTCCAGCGCTTTGTCCCGTTCACGCAGGACACCAGTGCGCGGGATGTGGAAGACTTCCT GGCCAGCCTGGAGCGCAACATCACGCTGGCCCCCAACGCCAGGATCCAGTTCTGGGGCGGCGAGCCGCTGGTCTACT GGAAGACTCTGTTCCCCCTGGCTCAGGCCTTGCGCGCTCGCTACCCGCAGGCCGAGTTCTCGATCATCACCAATGGC TCGCTGTTGGACGCGGAGAAGGCGCTGTTCCTGCTGGAGATGGGCTTTATCGTCGCCATCTCCCACGACGGCCCTGG TCAAGCCGTGCGCGGTGAAGACCCCTTCGATTCCCCGAAGGTGCGACAAGCCATCTTGATGCTGTACAACCGCCTGC GCCCGCTGGATCGCATTTCGTTCAATGCCATGATCCACAAGAACAACCAGAGCCGGGCCGCCGTGCAGAAGTTCTTC CAGGACTTGACGGGGGATCCTGATGTGCCGCTCGGTGAAGGAAGCTTCATTGATGCCTACGATGAAGGCGGCATGAT GCACACCGCCATGACCGACCAGGAGCATGTCGACTACCGCCGGCTGGCCTACGACGAGATCGTCAATGGCCGAGCAC TCAACTTCAGCACGATCACTTTCAAGATCCGGGACTTCTATGAAGGCCTGGACACGGGCCGCAGCGCCTACCACGTA TGGCAGAAGTGCGGGATGGACAAGTCAGACCGCATCACCGTCACGCTCAAGGGCGATGTGCTGACCTGCCAGAACGT ATCGACCACCTCGACGGCCCCCAATGGAGCCTCGCATCACGCCGGCAATATCGAGCGGATGGAAGAGGTGAAGATCG AAACCAGCACGCACTGGCTGGGCCGGCCGAACTGCCGCTCGTGCCCCGTGCTCCAGCTGTGCCGTGGCTCTTGTATG TACTTGCAAGGCCCGCTGTGGGAGGCGAGCTGCGCTGCCGCCTACAGCGACAACGTGGTGCTCCTGGCCGTGGCCAT CAAGGAGCTGACCGGCTGCGAGCTGGTTTCCATCAACCCCCTGGATGACACGTTGCCGGAAGTTCGCCGCAACGTAT TCACCGACCCCATCATCAACACCCCGGCTCGGAAGATCATTCCGATCAACCTGGAGAAGTAAAATGCAAAACCCTCA AGAAAATGCTCCCTCGGATGGCTTCCAGGACGACGCCACCAAGACCCTGATCTCGGTGCTACAGCGTCAAAGGGACA ACACCATGAACCAGCTGGCCTACGCGGAGGCGCAGTTGATCACCATGGAATCGCATCTGAAGCAGGTCTCTCGCCAA CAGACCCTTCTGAACGAGGCTTACGACGGCCTGATCAAGGCGCACGCAGCGATGGAAGAAGAGCTGACCACGCTGCG CAACACCAACGCCCAGTTGGTCGCGGCTATTGAGCGCACCAAGGCCCCGCAGCAAGACGGCGTAGTCGCCACGTTGA TGACGGCTGACAACCCGCTGGCTGTGGTCCCCAGTACCACCGATAAGTCGCCCAGTAGCGAGCCGGTGACGGCGAGG GGGTCGGAAAGTTGACGACCAACAGGCTGTCATCGTGCTGGAAGAGGCCGTGAGCGATTTTTTCCGCAAGGCCAAGG GCTGGATCCAGGATGCCTGGAATCAACGCCCCTGGGGCCGGAAATAAGGCCTCGCTCCATTGGTGAAAAAGCGCCCT TGACGGGCGCTTTTTTCATGCCAGAAAACCTTTGGGAAGGCTAGTCCTTCCCGGGTCTCGTTCCTTGCCTTCGGAGA AGAGGATCGGAATCTGATCGAAGCGCACGAATCCCGGCAGGCCCTTGCGCACACTCTTGACGTGCAGGTTGAGCGCT TCGACCCAGGCCTGCGCCGTGATGTGGTCAGGGAACGGCGCAAAGGTCCAGTCGTTCCCCTTTTCGTACCCGACGAG CGAGAACTGATCGCTGTACTGATGCACGCCGGGCTTGCCGTTGTCCCTGTGGGGAATGGCAATGGCCTCGAAGAAGC CAAAGGCCGGATTGGTCGTCAGTACGCCCGGGTCGGTCAAAAACTCCAGGCGCGCCTTGACCCACTTCAGGAAAGCC GAGCTTTTGACCGGAACGGGATACGGGCTGTTGCCGAAGTAGACGACATCATCCCAGGCATACGGCTCGCCCTTGCG CTTGCCGCGATAGTCGCAATCGCTGGCATGGTAGATCGTGTTGGCCACGTAGTGCATGGGGCTTTCGGTCGAGTGCA GGTGCCACTGGATCAGATGGGCCAGCTCGGGGAACACCTTGGCCACCGCGTCATGCAGACACCCGCACGACTCCACC CGGTCCCCGTAGATCTTGGGGTTTTGCTGGGGGTTGTAGAGGGTAGCCGTGATGGCGAAGTCGTTGTGGCCATTGCG GCAGTTGTCATCGAAGCGAACCTCGACGATCAGGGACTTGTTGATTCCATCATCCATGAATCGGCGCGAGGCCACGA ACTTCTGGTGCATGAAAGTCACCTTGCCATGCCGGCCGGGCTGGGGCCACTCGATGCGGGTCATGCGACCCTTGATG CCCAGCATTTCGTGGGGAAATTCGTTCATTTTGACAGCCATGATGATTCCTTGTTTGCGTGCTGAAGAAGGGTGGAT TTAAACCGCCACCTCGGTTTCCTTTTCCCCGGGTTCGAGGAACGCCGGAGCGTAGTTCAGGCCGATGCCCTGGGTCTTGGAGGCGCGCTGGCGGTCCTTGTTCATGGGCAGCAGTGCCAGGGCGCTTTCCTTGATCCATTCGATCCTCGGGTCG CCGTCGACCAAGAACGTGACGTAGTACGACACGTCCGTGATGCTGCGTCCTTGCTTGTCGTACTCGATGGTCGAGCG CGACTTGTGGATCAGGCAGATGGTGCTGCCCATGTAGACGATCTGGCCGACGCCGAATTTTCCGGGCGGCGCACTTT CCAGGTAGGTCTTGATGGAGTCGTCGTGCGTGACGCACTCCTTGACCAGGGCTTCGGGCAGGAGCAACAAGCCCTTG ATGTGGACGCGGCCGAACTCGTCGGCGATCAGCCGGCACAGGCCGAGGTTGTACAGGCTCGAAAAGCCGTAGTTCGA CGCATAGTGGCTGTCGCTGGCGCGAGCCTCGTTGATGTCCAGGGTGGATTCCGCGACGGTTCCCGTGACCCACTCGA TGAAACCTTCGGAGGTGATGGAGTTGGCGCGGATGATGGGAAGATGGTCAGCCATGGATTGCTTCCTCGAAAACGAG TTGAACGAGATCCGTGGTTTCGAGGCGTTCAAGTTCGTTACGAACCGCCTCAATCTCACTGAATCGAGTATCGATGG GGGATTGACGTTGAAGGGAGGCCAGCTTGGAAAGAAGCCCTGCGCGTCTGGCCAGCACAGGTTGGATATCCCGGAAC GTAATGATCACTTGGCCACCGGCATGTCGGGAACCGCGTTGTCGGTGAGACCGAACGCGACGACCGGATGATCCGTT CCCTGCACCCACAGGGCCAGCGCATGGCCGTCGAGAAGCTTGGCGATTTCTTCGTCGTTCAACCTCCAGATGGAAAC CATCCAGGGCTTGCCGCCGTGCTCGGTGTCGATGACCGGCAACGCCGTGCATTCGCCCTGGGTTTCCGGGTTCCAGT CGGCAGGTGCGCCAAGAACCCGGGTTGCGTTGTTCGGGTGCAGAATATCCATGTTTTATCCTTTATGGATGGGAGTG GGTCGGTACGACAGGAAGAGTTCCGGGAACGCATTCTCGAAACGTCTGCGGTTCAAGCTGTCGGCATGGAACCAGAT GGAGGCCAATCCCTTGGCATGGCTACCGCCCATTCCGAAGGCACGGACCATGGCTTGAACTTTCTCATCGCTGCTCA TCATGCGCACCACCAAGGCGGCGTTCTCGTCGTTCTCGATGTTGACGTGCGCCGCCGCCTGATGCAGCGCCTTGATG GCTCGCATGATCTTCTGGGTAAAGCCGATGATTCCGTGCCAGCACAGGTATTCATCGAGCAACGTTTCCGGGCTGGA GTGGGCGATGTCGAAATCGCTCAACCCGCGAGAACGCAGGTCGGCCAGAATGTCGGTCGGAATGGCCGAGATGTCGG TCAGTTTCATGGGGATCTCACTTGACGGGATACAGGGTGCGGCGCATCAGGTCGATGGCGCTGGGGAAATCGTGGCC GTTGTTCAACAGGCGCACGAGAAAGGGCGCACCTTTCTCCTTGATCTCTTCCTGAATTTCCCTGGTGACAGGCTGGC CCATGACGTGGCCGAGCGCCTGCTCAAGTTCCTTGAGGATCATTGCGTCTGTGTGCTGAATGGAATTCATGATCAAA CCTTGGGTTTTACGATCCTTCCCACAATCGGCAGGGCAAGGACGAATATGACGAGAAGAATGATGATGGCCCAGGCA AGCCCTCCTAGGTTGTAGGGGAGGCGAAAAGAGGTGATGTGGTCTGCAAGCCACCAACTAGCGTCCAGCAGCAACTG CATACCTACGACGTAGGCAAGCAGCGCTGCGATGAAAACGAAGGTGTACTTGAGCCAGAGCATGGGCCGTCCTTGAG GGAATGGCCCACATCATGCCATGAAGATTGGATCTTGGGAAGTTCGTTACGAACTCAGTAGTTGTAGGTGATGGCCA CATGCACGATGGCACGGCGGCGGCCGATGAAGCGCACATCGGCGTGATAGCTGGCGCAACCGCAGCAATCATGCTCG TGGTGGCAACCATGCCGGCTGAACTCATCCCTCAAGGCCTGTTTCCACAGATCCTGACTACCAGTCCTGGGGGTGAT GACGTGCATCAGGTACACGGGGCCATGCGACGGCTCGTCGTAATACGAGGCCGGTTGGTTGATCACGCGGCGGCTCA GCACCTTGACCTCGCCCAGGTAGGCGTAGTCATCGAGATCCTTGAACGTGCCGACGAACTTGTGCGTCAGGCGCAAG TACACCCCTTGACTGTGTGCCATGGTCACTTTTCCCTTTCGACGCAGACGAGATAGCGAATCTCGCCCACTTTGCTG TTGGAGACGGCGGTAAAAAGGTTCGTGACGAACTTTCTACCTTGCAATTCCTTGACGCGGCGGCTGGCTGGCGGGTT GAGCCTGTGCATGAGCCGGGCGTAGTCCAGCGGGCGAGTGTCGAAGTAGCGACGCTCGCCCACTTGGAGCGTGGCCA GCATTCCTTGCCAGCTGTCAGAGCGGGGTCCGGTCATCGTCTTGCACCTCTCTCACTTGGACGTACATGGGCCGGTT CAGCGAACCCAGCAGCAAGGCCATTCCCAGGCGCTCCAGGCCGTTGAGCGGGCCGCTCATGGGGTAGCTGGCCACAT GCCCCTCGAATTGCTTCACGGCCGCTTTGACGGCCTCGTATTCGATGAAGCCCGCGTTGCCCAGCTGGAGCCGCACC AGGGGCGCAATGCCCTTGGGCACCAGCTCGGTGTGCAGGCGCTCGATGAGCGCGCCCACGGTGTGCTCGGGGTAGAT CTTGTCTTCAGCCATGATGGACTCCTGCGGCCAGCGCCAGCTCCACGATGTGCTGCCAGCTCAGGTGAAAGACACGG CCGGTCTTCTCGCACTTGACGGCCGGCGACATGTCGACCATGGTCATCATCTCGAACTCGCCGACATCGGGCACCTG CGCTTCGCCCACACGCATGGTGATCATGAGCTTGTCTTTCTCGATGACCGTTCCCGCGCCGGCGTTGTAGCGCTCGA TGATCGTTTCGAGGATGTTGGCCATGGCTTCGGGCGTTCGAATCACCCCGTTGGGGTAGAGGGCGGTGCGCTTGGAG CCATCGATCAGACGGCCGGGCAAGCCGCCGATGGGCACGCCTTCTTCGTCCACGAGTTCGAGCTTGTCAGCGGGCAT GGTGGCGCGCTGGAGTTTCTTGGGGATGGAATCGGGGTTGTGGGCCATGTTGGCTCCTTATTTGGCCAGGGGAGGGA CCAGCGACTTGAGCGCGCTGTCGATGTGCGTGTCGTTCAGGTACGCATACATCTCATCGACCAGCTCGCGGCGCAGC TGCACGTAGATCGCCTTTTGCATCGTGGGGATCTCGATGGTGGGAACGTCGCCCCACATGCAGTCCCAGCGGTAGCG CATGTCGAGGTTGCGCACCATATCGAAGTTGACGATTTCGCCGCGCTTGTAGCGCTCGCGGTTCTGCGGCGTGTCGG AGTGCTTGATCAGTGCGGCCAGACGTTCGAGATGATCCTTGGTGATCTTCATGATTGATCCTTGCAGGATGGTTCGT TACGAACCAAGGTGAATCCAGGCCGCCTTGATGAGGGACCAGAGGATGGAATAGGGCAACGTCACGCCCAATTCAGC CCACAGGTCGTAGATGGCCAATGGAATGAAGCCCGTCAGCAGCAACAGGCAAAGCGAAGTCTCCACCTTGCGGCTCG TGGGAATGGCCGAGCCGTCGGCATACTCCTTTTCGCCCTTGTTCAGGATCACGAGATAGATGAAGCCCCAGAGGGAC CACGCCCAGATAATCGCCATCACGCCGACGAACAGAACGGGGTTGAGTATCAGCACCAACCCGATGACAGGGACGAT CATGACATGGCCCCATCGGCGATGTCCCAGCACGCGATCCAGACGAGGTACATGTGGACGGTTTGATCGTCCATGGC GTCCACGCCATCGATACCGACTTCGCGCAGGGCTTGACGCACCAAGGGCATGTCGAGCGCGGCCAACTGGATGGCCA GTTCGGGGACCATGATGGCTTCTCGCGCAGCCGGCGTGTTGTCGCCCGAAGTGGCCACCGAGTTGACCACGGTGTCG GGCAGGTTGAGTTCGAGACGACCGGAGCCATCGGTCCAGGTGTGGTCAGACATCGCGGATCTCCTGGTTGTTGCGCA CTTGCTTGCCGTCCTGGAACATCAGGACGGTCGCGCCGGTTTCACGGCGCGATTTCTTGTCGTGCTCGTTATAGACG GCCTTGGCTTGTTTGCCATTGTGGCTTTCATGGACCACTTGACCATTGACGGTGATGCGGAATTGCTGGCGCATGAT GTCCCCTTAGATGGAGCGGCGCAGTTGATCGGAAAGCAGCTTGAGCTGTTCAGCCGGGAAGTCCTGCGGCTTGCCGTCGAACCACTCGTGGATTTCGACATCATGCAGGAAGTTCGGACGGATGGAGACCGTCACGCGCTGGATGAAGCCGACC CGCGGTTCCCTCGTGTCGTGCAGCATGAAGACAATTCGGTTGGTGTCGCAGGAATCGATCTTGATGTCGACTGCCAG ATTGCCGACGGCGACTTGGCCGTTGAGATGGTCCATCAGCTCGGCCAGCGTCTTTTTGGCCTGGGAAAACTGGGCCG TGGCGTCGGTGAAATCGGAACCGACGGTGGCCAGCTCGGTGTCCACCATGATGGATCGGCTGGCCATCAGTTGCTTG GTGACGCGCATACACGTCTCGGCTTTCTCTTCGCTTTGTTTCATGAGCGCCAAAGCGCTGGCGATGTCTTTGATGAG CATTGGATTGTCCTAAAAGTTCGTTACGAACTACACAATTCAGAGGTTGAGTTTAGTAACGCTCCTTTCTGGTCAAG AAGGAGTCCATCAACTCGTGGATGAATGACTTGATGTCGTTTCGGTTCGGGCCTGATACCTTCATGTCGAAACCAAA GGCCAGGGACGGGGTGACCACGATGCGATGCTCGGTCCATCCGTCATAGGAGCCGTGTTGGCTCATGTGATGGAAGC TGGTTTGGAAGACGAGACGTTGAGGCGTCGATTCATCGAACAGGAATTGAGTCCCGGAGTCGAAACCGGAGCCATGG GGAGCGAAATCACGCACCAGCCAGTTGATGCGTTCCTCGTGCATGACTACCCACGAGTCGTTCGGGTCGATGGCCAT CCGGTTATTGCGAGCGATGAGACGCTGCGCAATGACTTTGTAGATGTCATTGGTAATCAACGCCGGATCAGGGTTGA CTTGGGAATTGGTAGCTTGAGTCATGGCGTATAGGGCTTGATCTTGGGGACGCCCACGGCCCGTTTGCGGGGTTTTG GCCGCTGCGTGGCTGGGGGCGAGGGTTGGGGAATGGGTGGTCATAACCCCTTCACAGCTCAAGCGCATCATGCCCAA CGCCGCGGTCTCCCGCACGGAGTTGTACGCGCCCCTGTTGAGTGACGCGATGGCCAAGTGGCACATCGACACGTTCG AACAGGTCACCGCGTTCATCGCCAACGTTGGCCACGAAAGCGGGGAGTTGAACTACACCGAAGAGATCGCCAGTGGT GCGGCTTACGAGGGTCGTCTTGATCTCGGCAACACCCAACCCGGCGATGGTAAGCGTTACAAAGGGCGAGGACTGAT TCAACTGACCGGACGCACGAACTACTTGCTGATGGGCATCCTTCTGGATCAGGACTTTATCAACAACCCCACCTTGC TCATGCAACCTCCGTTCGCGGCAGAGAGTGCGGCGGCCTTCTGGTGGAACAACTTCCTGGACAACGTTGCTACGTCC AGGGAGAAGTTCATCACCGTGGTCAAACGCATCAACGGGGGCACCAATGGTCTGCCCCACCGTGAACAGCTGTATGA GCGTGCTCGTAAGGTGCTTGCGGAGTAAGCGATGAACCACAATGACTTCATGGGCCGGCTGATGTTCACGGCTTGGA CTGTAATCGTAGTCATCCTGGCCGTCACTCCTTCTGGCTCGATCCCCGAACTCAGCACCATCTATGGAGGGAAGATA CTGACGCCGCTTCTGGCGATTGCGTGCCTGTTCTTGATCGTGGACTTGGTGATTAACGACTTCATGCCGCCGCGCTA TGTGTTCCGTAGCGCGATCAAGTGGCGTACTTGGGCCTACATCCTCTCGTCTTTCGTCTTCACCGCTCACCTGTTCG TGGTGGCTCGTGCCATGGGTTTCATTCAAGGCGGCGCAGTCATTCTTTACACGACCATGGTGCTCTTCGGATTGCTG CTCTCGTTTCGCAACATCTTCTGCCTTCGAGGGAAAAAGCGTGCAACCGTTCATTAAATATTTGGCCGCCATGACGG CCATGCTGTGGGGCGTGACCTTCACCGCTGCGGTACGCGCTGAAGGTATCGGGTATCGCATTGGCACTGACCTTGCG AGTATCCCGTTCTCGGCTTACGTGATCGTCACGTTGCTGAGTGGTATCGGTGGCTTTGTCTCGACCCTCATCCGGCT CTCGAACGAACCTGATGAGAAGCTTGTTCGCTGGAAATTGCTCGTTCTGCGCGATATGGCGGCGTCGTTGCTGGCCG GTGTTGTGGTGTTCTTCTGGAGCGAGGCTTCGCAGTGGTCGACCGCCAATGCGGCGATCATGATCACGCTGGCCGGC TTCGGGGGCACCAAGGTGCTCGACCTTCTGGTGGAGAAGTTCTTCGCCAAAAAGGAGCCGCAATGAAGATGATCTCG CTACAGACCACCCTCATTGCGGCCGCAATAGCGCTCGCTGTCGGGGGCGTTGGTGGTTCGCTGACGGCATGGAGTCT TACCAAGAACCATTATGTCGCCAAGATTGCGGAAGACCAACGTACAGCAAGCGAGCAAGCTCGCATCGCTGAACAAA AGCTCAACACTACGATTGCCAACCTCAATTCTGATAGCGCAAAGGTGCTGGATCAAGTTTCAACAGCTTTTCAGGAG AAACTGAATGCTGCCGAGAAGAAGTATTCGAATGTTGCTGCTCTCATCGCTGATGGGACTTACATCTTGCGCGACCC ATACGCCAGTGGCTCCGGTCAAGTATCCAAGGATCGAGGTAGCGCCGCCGCCAGCCCCAATCCTGGTCAAGCGGGAG GCCAACTTTCGGCAAAGGCTACTCGATTTCTTTGGGGAGAAGCTGAACGAGCCGACGCCATCACCGAAGAACTGACG GCTTGCCAGGAGGTCGCTGTGGCCTACTGGTCGATCATCAACAAGTATGGTCTGGAGATCGAAGCCCTGACCAAGAC CATGGAAAGGTAGTCCCATGACTCAACAACTTCTGCCCACCAACGTGGATGGCCAACAAGTCATCTTGGTGGTCTCT CCTGTGGTGTCTACCGGAGACAACATCGTGCCCCTCAGTCTGCTCTACGGGAGCGGCGCTCCCGCCAACAACGTCGG CAACGACAAAGAGTTCTACCTGAACATCGACAACTACCGCCTGTACGGCCCGAAGATCAACGGGCTGTGGGGCGATG GTTATCTGCTCAAGGGGGACAAGGGCGATAACGGAAAGAACGGTGACATCAACAAGGAGACCTTGACCACCCTGATT GGCAACATCGGTGCCACCGACACGTTCAACGTCGACCTGTCCACCTCGGCCTCGGTGTTCAATCTGAAATTGAACGC GGGCAGCAACACCATCATGTTGCAGAACTCGAACGTGGACGAAGGCATCGCGCCCAGCTTCACGCTCGCGTTGGAGC AAGGCACCGGCAGCAATCGCGTCGACGCCTGGGATCCGAAGATCCGCTGGCCCAACAACATCAAACCCGAGCTGTCG TACCAGCTCGGCGTGCGGGACATCTTCCACTTTGTCTCGTTGGACCGCGGTGACTCGTTCATCCCGTTCTACATCGG CGGCAACTTCCCGGTATAAGCCATGCGCATCCTGTACGCTTCATCTTTCTCGCGCAACACCCCCTACGCCCAGAACG CGAGGGTGATGGCCTCGGGCTTTCTGGATTTCCTCGCACGCCACACGGGACGCACCGAGTCGAGCACGCCGGCCGGA ACCTACGTGATGAACGACGAGGGCATCCTGGCCGTCACGCTGCATGACGCAACCTTGGATTATGGCTGGGACTACCA GACCTCGCTGTCGACCTATCACGTCGAGATGATCCAGGGGGCCTTTGCCATGTGGAAGGCCACGGGTGAGCGGCGCT ACTACGACCTCTTCATGCAGGTCTTGACCGCTTATCGCACCCACTTCTACGGCGGCGTGGAAATTCCGCCGTTCGCC TCGATCTGGCGCGCCAACTACATCATCAACGCCCGAGCGCCTTTCACGCTGGGCGCGGCCACGGTGGGCAGGAACCA GCCTTACGATCCGTGGCCGGCTGGCCAGGAGACGGCCATCACCGATCCTTCGGTGATGGGCAACTACCCGATGGTGG ACCTGGAGCTTGCCGAGGTGTTGATCAACGCCTTCCAGTACACGGCCGAGCGTGACTTCCAGGTCATGATCAACTCC ATCCTGTACACGGTCTTTGACTTCATCTCGAACATGGCCGAAGGCAACCCCGGCGCGGGGCTGCCCTACGTTCCTGG CGCGGTGCCGGGGGAGCCGGGCGACAGCCCGCGCCTGATGCGCCGCGCCTCCTGGTCTGGCATGTGCTACACCGCCT ACCAGTATCCGTCGGGCCTTGCCGTGGCTGGCCATGGTGACGAGATGATGAACGTGCTGGCGCTCTACGAGGACTCC CAGAACGCCTACCTGCAACAGAAGAACATTGATGGACCGTTCTTCACCATGTACGCCTGGGACCGGCCGGACAATCCGCTGCCGGCTGGCCAAGTGTGGGGCGCAAGCCGCGTTGTCTCGGACAACGCTCGCACCTTCATGAACGCAGCGCGCC TTCTGGCCGTGCTCACCGAGCGCAACACCACCATCCCCACCTCGCTGGTGGACATCTGCACGCGGCACGCCAACTGG GTCGCTCAGTTCGTGGTCGACAATGGCGCGCTGCCCGTGTTCGACGCCAACATGCTGCCGGTGGTCGAGCCTGTTGG CTCATACGATTCGACGCTCGTAGCCACGCTCTATCTGACGGGCTTGATCTACATGGCCAGAAGTGATCAGATGACGC CCGCGCTGGAGACCTTGCGCCAGTTTTGCTTTACCGAGATGTCCAAGCTCTACAGCATCGAACCGACCAACCCGAGC ATGTCCGGCGCGTTCTCGCCGAGCGCGGCAACTGGCCAGTATTTCTCGGAGCATGGTGGTCTGATGCTCCGCGCCCT GGGGGAGTTGATCTCCTGGGAGACCCGCTTCGATCCTGCCGTGGTTCGACCTGTCGGTGTGGCCAAGGTCTTGCTGG AAAACGAAACCGGCTTCGTGCAAGTGGAGACGGGTGATGGCGTTGTGTTGAAAGAAGAATCTCAGCCCGAGGAATAG GAAATGCCTGATCTCAAGATTAGCGAGTTCGAAGAACGGACTGCGCCCCAAGGAAGTGAAGACCTGGGAGCTGCTGA AGGCGGATTGAACATCCGCATCAAGCTCTCGACCCTGCGTGTGTTCTTGAACGCGGCCTGGGGGGACTACGCGGGCT TCATCAAAGCCTCCGAGCGCTCCAAGCTGGCGGGCATCGCGGCCAATGCGACGGCCAACTCGTCCGATGCCTTCCTG CTCAACCGCGCCAACCACACCGGCTCGCAGTCCGTGGCCACGATCACGGGCCTGGGCAAGGTGGCCACGACCAACCT GTACAGCGATCTCGACGGCCGGCCCACGCTTCCTGGTCTGGCCACCAGCAGCACGCCCGGCTTGATTGCGCTGTCTC CTGGCATGACGCTGGATCCGCTGACCAACCAGCTGTACGTGACGCGCTACACCGAACAGCCCGCGCTGGACGCGGTG ATGAAGTCGCCCGAGATCACGCTTTCGAATTTCAACTACACCGCCACTGGCAGTGGTAACGCTCAAGCGGCAGTGAT CGGCACCACGGGCAACTTCGCCGGCAAGTGGTACTTCGAAGTGGTGTTCGCCTCGGGCACGCCCAGCCCGGACAATG CGGTCGGCGTCGCGCCGATCAATACCGACCTTGATGGCATTGCCGGCGTGGTCGGCGCGGGCGCGGTGATCCGTCAA TCCACGGGAGCCATCGCGGTCGACAACAGCACGACCACCGCTCAGGGCGCAAGCTACGGCACGGTGAACAATGTCGT GCGCGTGGCCATCGATGCGACGGCTGGCCGCGTCTGGTTTGCGGTGGGCAGCTCGCCCTGGAACGCGAACTCCAGCG CCAACCCGGCCACGGGTGTTGGTGGTCTGGCCATTGCGCGGCGCAAGCTGTATCCGTTCATCTCGCTGGCCACGGGT GCGAGCTTCACCGTGCGCTTCGGGGGCACGATGTCCTTCACCGCGCCGGCCGGCTTCGCTCCCTGGTCGGTGTCCTC GCAAGGGATGCGACTGGCGGACATGGCCGATGTCGACTCGTCGGGCTGGTCGGCCGACCTCGTGCTCAAGTACGACA CGGCCAGCGGCAAGTGGAAAGCGTTGCCGGAAGCCGACTACGTGACCGAGGCCCACAACCTCGTGAATCAAGCCACC CAGGCCGCCGAGGATGCCATCGCGGCCAAGGACGCTGTGGACGCCACCGTCGATACGGTCAGCGGCTACGCGGCCGA CGCGCTGGCTGTGGTGGCGCAGTTCGATGCCGTCCCAGTCTTCGGGCATGTGCTCGACAGCGGCGAGCATTTTCTTT TTCACCGAATCCATCAGGTCGGTGATGAACTTCTTCTTTTGGGCCTTGTTCAGTGCCATGGTTGATCCTTGGAAATT GGAAGATGAAGTGGAATGAATGATACACCAGTTTGGTTAGGAAGAATGGATCTTCAATAAAATATTTATCCTCCATG CTTGGAACATGAAGACGAGGATAGCCCCTTGACAAACGGAGAACTATCCCCCCAAAGGATGAACCATCAGCCGTAGA TGACGGCCCCGAAGTAGGCAGCTTGCAGGATCATGTCGGCCCGCCATGCGTCGATCTCGCCGGCATCGTCGGCGATG ACCGCCGACAGGATCTCATGACGGTAGGTCTCATGGACGTTCGGGTCGCCGTCATCTTCGGAGGTCAACGTGCCGGC CACCAGCTTGGCCAGCCCCTCGCGCATCATGGGCAGCGTGATGACCTTGGAGGATTGGGCTTCCTCTTCGTCACCCA TGTCTTCCACCGTGACCTCGATGTAGTTGGACACGATGTCCTTGGGGTCTTCCTGTTTGACCTTGGAAAAGGCCGCC CAGCTGGTGCTGTACCCGCTTTCGACCGCCGTGCAAAGCACGTCGGCCAGGAACTGGTCACTGACCGGAACCACCAT GACCATCTCGTTGTTTTCGTTCAGGCTGACTTGCATGACTTGATCTCCTTTTCCATCTTTTCAATGGAATTGAACGC CTTGTGGGCGTCGTTCTTGAGGCTGGTGATCACTTCCTTGAGGGTCGTGATCGCGGCGGACTGCGGGTGAAAGCTGC GCAGCATACGCATGGCAGCGTAGAGGGAGCGGCGCTTCATCCTGAAATCCTGGATGTTTTTTCGCTCGTCGGCGATC AGGCCCTCCAGGTCTTCGATGCGCTGCGCGGCTTGGTCTTTCTGATACCAGTCTCGGCCGTCTTCCGCGAAGCGTTC GGCATATCGATCAGCCGAACGCGCCGCTTCCTTGGGGTCATCGTCGCACTCCAAGGGCCACGCCATGACTTCGCAGT TTTCGCTCTGGTACACGGCAGGGAAATAGCGCGGCTTGCCATCGCGGGCCGGCATCTGGAGAACGAATCCACGGACA GTGCCGTAGACCGAACCTTGTTCATCATCCATGTACCAGCCTTGATGGTCGAGTCTGACCAGATCTTCAGACCATCC CGCGAAGCGGAACCCGGTGTCACGGATTTGATCGTTGACACGACGGGTGCTCATGTAGATGTACCGGGTGGCGCCGA ACGGTTTGGGATTCTCGGCGTCGAGCGTTTCCCAGTAGATGCGGTCGGCGTGGATCCACGGATTGACGTAGAACTGC TGCCATCTGGCAGGTTGAACCCTGGATTCAGCAGCGCTCTTGCGCGCCTTGGCCAGTCGGAGATGCGCGGCTTGGAT ACGGGTATTGTCGATGTAGCTGTAGCTTTCGGTGCCCATGATGGCTCCTTGTTTGTGTGCTGAAGGGAGGGTTAGAG GTTGTCGAACCCTTGGAAGATCTTGTCGATGTCGAACGAGCCAGCCGGAAAGGCATCGTCGTCTTGCAGCCCGTCTT GCGAGATGCGGATGAAGCCTACTTCGTGGCCGGCCAGACCGCCGATCTCGGCCATGACGTTCATGTGGGTGTCGGCC GTGTCGATGGCAAGGCTGACCGAGTTGTGGGGCAACTCGATGTCAATGGCGACGGCAAAGATGATGCGATGTTTCAT CAGAAGTACCCCTTATGGGAATCCCAGCCGCCGCCTTCGCAATCGACTTCATCGTCGTGACGGCCTCGGATGTCGTT GTTGGTATCGAACGCGAGCTGGGCTTCGGCCACCGTCAGAACACGCGGGTTCTGGTACTTCAGCTTGCTCACGATAC CGTCGGCGATGTGGCGAACGTGAACGCGCAGCACGTTCTCATCCAGCACTTCGGTCCAGTAGTTCTGGCCGTGGCGC ACCTTGTTGCGATCCAGCATGAACAAGGTGACGCGGGGATCATCTCGCTTGTTGCAAGCGATGATGTATTGGCCGGC CGGGCGGGGTTTGTTGGGGTTGTCAGTTTTCATACGATTTTTCTGGGTTGGGTTCGTAACGAACTACAGGGCCGTGA GCATCATGAACTTCCAATCTTGCTCCGGGTTATGGGCGCACGGCACCACTTGAGACTGGCCGTTGTAGACCACACCG TCGGCGTAGTTGGCCACGATGACCCAATGCTTCTTGTGGGTGTTCAACATCCAGATGTAGCCGCGCCCCGATTGGCC ACGAGCGAATTCTCGGGCTTGTTCAGCCGTCATCCTCACCGGGTCGTTGTCCGCCCATCCTTGGCCGAACTTGAATT GATACTTGGACATGATTGATCCTTCAATGAAACGAGTGCGCCAGAATGAAGAACAGCGCCCACCATCGGGCGTTGAA CAACAGGCACACAATCGCCATGATTAGGGTGAAGTCGAAGGTCATCATGCCGGCGGGGGACTGGCATTGAAGCTTTCGTGTTGAACCAGGGCCTTGACCAGTTCTTCGGCCTTGTCGGCATGGCCGCGCTCGATGAGCGCGCCGACGACGCAGC CGGCCAGCGCGGCCGAGCGAGCGCCGTTGCGCAGCCGGCCGGAGACGATCATGGAGCTGGCCCAGCCAACCGGCAGG CGCTGCTCGGGCGGCAGGCCGACGAGGTTGTGGACGATGCGCGAGGTGAGCGCCTTGTAGGAGTTCAGGCTGTGCGT GTTCATACACGCCTCCAGAATGAGTAAGGGGTTAGGCCGAGGCCTGGGCCACGATGTGGTCGGAGAACACGACCGGA TCGACCAGGCCTCGCTTCTGGGCCTGTTCGAGCGCTTGATCCGCGCTGTTGGCTTGTACGTGGTCAACGACGATGGA TCCATGATCGACGTGGGCGACGGTGAAGGCCCTGCCACTCGCCAGACCGTAGGCGACAGCGAAGGACGACAGACCGG GGTAGTTCTCTTCGCCGCCATCAGCGCGGTCTTCGATGCGGACAGCGCCGTCCAGGTGGACGCGCCGCACATACACC CAGTCACCCAAATGGAATTCAGCCCCGTGGTCGGGGCCGACGGCGTTGAGCACACACATGGCGCTGTACACGGTTTG GGCCTGAATGGCCGTGAGGATCTTCATGCGGCCTCCGTCAAGCCCATGGAGGGGTTGTGCGTGAAGCTCACGCGGCG ACCACTGCCGGCCTTGATCGAGTGGACCTCGTTGAACGCCGTGCAGGCGTTGTCCCAATTCGTCTTGGCTTTGGCCA GCGCCTCGGTGGCGTGACGCAAGGCTTCCTCGGCCTCGTTGTGCGCGATGATCGCTTGCTGGTAGGCCGACAGCGCC TGGACGTGGTTGGCCAGGATTTGTTCTTTGTTGGTCATGTCATGACTCCGTTTGAGTGCTGCACGTTGAGGAAGGGT CAGCCGATGAAGATGAGAACTTCGAGGTCGGCGTCGAACTCACGAGCCGAGCCGCCGAGTGGGGCGGCTTCGGTCTC CGTGAGTTTTTCGAAGATGACATCATCATCCACGAATTGGAAGAATGCCCCGAGGGGCAGTTGGTTGAAGGTCACGT CGGCTCCAGTTGTTCGCGGTGCTCGGTGAACGTCGCCGACCAGCGCATATCCTGGTCGACACGCACGCCCAGGATCA CGCAGCCGGTCTCGGCCGCGATGTGATCGAGCACCCCTTGGGAAAGGGGCCAGCACGGCGTGAACCGGGTGTCGACG TTTTGGATGGTGTGGTCGGCGATGATCTCGTTGATGCGATTGATCAAGGTCGGCGCACGCAGGGCGATGCGTTCCTT CAGCGCGGCGAGCGTGAAGAACGGCCCGCAGTCCGGGATGAAGTTGTGCATGTCAGATGTCCGCCAGTTTGTTGACG GCCACGCAGTCCGCCCAGGCCTGGGAGGCCGAGGTGAACATGCTGCCGCGTTCTTCGGGAAACAGCACCTTGAACCA GAAGAAACCGCGGCTCGAATCGGCGACGGCATAACCGGCCGCTTTGGCCAAGGATTCGTTGTTGTATTTTCCACCCA TGTTGGGCTCCTATTGGTTGTTGACGACGAGCTTGAGGTACTTGACCGTGGCTTGCGTCACGGACAAGCGGGGTTGA CTGGGACGGGAACAGTTCCACCCCAGACGATAGGCTTCATCCAATGCGGGGCAGATGCCCGCGCCGTTGTGGTTCTG GCCATAGACCACGCCGCGCAGCTGTGCATCGTTCCAACCCCGTTGGAACGCGAGACAGCGGTTGGCTTCGGTGTTGG CCGGGTGGTCGTTGCGGTCGATGGTCTCTTCCATGATCAGTGGATGGTCTTGTTGCCCGGCACGCGGTTGGGTTCGA CCTGGGCGCGGATCGTCTCGTAGGCTTCGGTGCCGGGAGCGTAGTTGAGAAGATCCTGCATGTTGGGGTTGCCGTCC GCGTCCAGCGGAATGACCAGCATGGGCGCGTTGCCCTCGGCTATGACCTCGGACAGGCTTTCACCCATCTGGGCCTG CACGGCCTGTTCCATGGCCCTGGCGAAGGCTTGGCGGCCGGCCTGCTGGTGCAGGTTGTTGATCTGCGATAGCAGGC TGTGCAGGAAATCGAATTCCATCTCGTGGCTGGTCAGCTTGACCGGCAGATCTTCCAGACGGATGGTGGGCAAGCCC AGCTCGGTGAGCAGCTGGTTGCACACCACCTGGGGCGTGCTGGGGGCGTTGGCCAGCAGCGCCTCCATGTAGGTGGC CACCACCTCGCGGTGCTCGGGCAGCGTCTCGCCTTCGGGCAAGCCGGCCTGCCGCGCCTTGGCACGCAGCATGTTGC CGATCTCGCGCTTGAGGGCCTTGAATTCGGAGCCGGCGTAGTAGCGGACATGGCCGGTTTCGAGGTTGAAGAAGATG GCTGCGCAGCAGCTCAGGGCGATTTGAACGCGGTCTTGGTTTTCCATGATCTCTTTGGTTCGTTACGAACTATTTAC GAGGGCCGAAACGATAGCCCCTTGATATGGCCCAGCGGCGGTTGAATGATGCCGAGATCGACTCTGGTCTGCGCGGC TACCAGCGTGATCAAAAGCTCATGAGCGATCCTCGTTACGCGGCGCGCTACAGCGGCGTGCAGCGTGACTACATGAA CAACCGCATGGCCGAAGCTCAGGACGTGACGGATCGTGCTCAGTACGCCATCGTCACCAACAAGCTGCGCGAGATGG ACACGAACATGCAGACGCTGCGCAATCTGCTGGACACGTTCACTCCGCAGCTGGGAGAACTCGGTCAGGAAAACGGC TCGCTGTATCAGCAACGCTCCGGGGTGTTGGAGAACTCGGAGGAGTATCAACGCCTGACCAAGGAAATCGACGCGGC CAACGCCCGCCGTCGACAGGTGACCGAGGAAATCAACAAGCTGGAAGCCGACCGTCTGCCGGTGCTCGAACAGCAGA AGAACCTGTACGAGAACATCAGCCGCAAGCAACCCGAGTCCATCAACTTCATGGATGGGATGAAACAGGCCAACGAG AACTTCTTGCGCACGAACGATGAGACGGCCACCGCCATCGATGGCTATGGCCAGATGCTGAACACGTCGAAGAACTC CCTGGCCACCTTCCTCTCCGATGTGGCTTCACGCTCCAAGACGGCCAGTCAGGCGTTCAAGGACTTCGGCATCAGCG TGGTCAAGTCATTGATGGATATCGCCACCCAGTACGTGGCCATGGCTGCGATTAAAGGCCTGATCGGCCTCGTGGCG GGTATCGCTGGTGGCGCTGCTGGATCTTCCGGTGGATCTGCTGGCGCGGGCGATGTGATGACGACCACCACGACCGG GTTTGCGAACCAAGGCGGCACGGCCCGCAACGGCTCCATCTTCCGCTTCGCAGGCGGCGGCCGGGTTCCCGATGGCG TGCCGCGGGATTCGGTGAATGCGCTGCTGCGCCCTGGTGAGATGGTCATGAACACGTCGGCGGTCTCGGCGGTCGGG GAAGACTTCCTGGCGAGCCTGAACACCTACGGGAACCGGGAGGTCCAGCAGAGCAGCCCGCCGCGCCTGCCGGCCCA GAAGCGAGACCCCGACATGACCAACGTCTACATCGTCGCTCCTGGTCAACAACCCACCATGGGGCCGAAGGACGTTC TGGTCACCTTGCAAGATGATGTCTTGCGCGGCGGCCAGACCAAGAAGCTGATCAAGCAAGTTGCAATGGGAGAAATC TGATGGCCATCGTTGAAGACACCTTCAACTTCCCGGCACACACCGTTTCCGAGAAGTACCCGCAAAGCGGCACTCGG GTGCAGCTCGGAAACTCGTACCAGTTTGATTCGCCACCGAGTGGTCCTGATCAACGGATCTTCACGCTCAATTTCAA GTCCATGATCCGCTTGCTCGGTGATGACGGCTTGATCGACGTGGAGACTCGCAGCGATGTGAATGCTGGGGCGCTGC TGCGCTTCTATGAATCCCATCGTTTGTACAAGCCGTTCTACTACCCCCACCCGTGGCTCGGCAACATCATCGTCAAG TTCAACACGCCTCTTGAACTTCCCAAGGGCATCGAGAACGGCGGCGGATGGACTGAAGCCTTCACTGTCGAGCTGAT TGAACAACCATGAGATCCAATCTACCCGCCGATCACGTTGTAGATGCCTTCGAGCTGATAGGTCAGGCACAGGTTGA TCTTTTCAAGATCGAACTGAACCAGAACGGAGGCGGCACGGTCATCTGCATCAACTCCACTGTGGACCGGGTGTGGC AAGGCCGTACCTGGGAGTTCATTCCTTGCACCTTGCAAGGTGAAGGCGTGAGCACTCAGGGCGAAGCCAAACGCCCG AAGTTCACCGTGGCCAACCCGGAAGGAGCGTTCTCGGCCTTCGTGGCTCAAGGCAAGATGGACAACGCGACCATCACCCGCTACAGGGTCAACGTTCAAGACGTGATCAACAATGTCAACAAGTTCCAGATCAACATCTGGCGCGTGTCGAAGG TCTTGTCGATGAACAAAACCACCGTGACGTTCGAGCTTCGCTCGCCTCTCGATGGTCAGTTCTTCTTGATCCCCGCT GATGCCTTCTATCCTCCGGAGTACCCGCATGTCTCTCTACAGTAAGTACATCGTCGGATTTGAAGGCATCGACTACC TGGAAGGTAGGAACGACTGCTATGAACTCGTGCGCCGCTGGTTCAAGAAGCACTATGACCTGCCCATGGTCAACTAC GCTCGCCCGAGCGGCTTGGTGGTGCAGGGCGAGACGGTGATCTACAAGAACATGGCGGCCCTGGGCTTTCACATCGA CCAGAGCGCGCAGCTCAATCGGTTGCAGCTTGGTGACGTGCTGCTGATGCAGGTCAATACGCGAGCGCCGGAACCCA ACCATGTGGGCGTTTACGTGGGCAACGGCTATTTCCTGCACCACCTGTACAACCGCAAGTCCGTGGCTGACGCGCTA GATGCGCGGTGGCGCGCCCGGGTCATGGACGTGGCCCGGCACGCCGACGTGGTGGAACAGAACCGGGACGCTCCGGT CGAGACCACCAGCATTCTTGAACTGATGACCCCTCAAATTCGAGCACGCTATGAAAGACAATCTCCAACTTCTATGG GTATCGACGGTGGAGCGCTGCGGCCTAATACTCCGTGACGGAACCATCATTGAATGTCAAAATATTCATGAAGATCC GCATATCGGGGTGGAGATCTCGCCAGAAGATCTTGTGAAGTACAAGGACGAAGCAATCGCCACATGGCACACCCACC CCGACTCCAGTTCGAACCTGTCCGCTGAAGACTACGTGGCGTTCCTGAACTGGCCGGAATGGCGGCACTACATCATC TCCGAGAAGGACGTGTGGTGCTTTTATGTAAGAAACAACCTTGTGGTGTTGTTCGATGAAGAAGATCCATCTCCTTG GCTACTTGAACCAGTTTCATCCTCGACCCATTGAGGTTGAGGCCGAGACTGTGGCCGAAGCCCTGTCGGTGCTCAAG CACATTAAAGGGATCGACACCGGGACCATGCAGAAGCGAGTTGTGAGGATCCTGGGATTCGAGTCCCAGGATTCCTT GAACACGCCCACCGATGTGGTCGACATCTACGTGGTGCCCACGCTGCGCGGGGCTGGTGGCAACGGGGGCTTCTTCC AGATCCTCGTCGGCGTCGTGCTGATCGTGGTCGGCGCGCTGACCTCCTGGTCCGGCGGTGCTTCGTTGATCGCCGCC GGTATCGCCATGATTGCGGGCGGGATCTTGGCTATGTTGGCCCCGACCCCGAAGATATCAAGTTCTGACTCTGATGG TCGATCTTCGTTGTTCATCCCGGCCAGTCAGAACACGGTCAAGATCGGAACTCGCAAGCCCATTCTCTATGGTCGTA TCAAGCACTACGGCCATTACCTGTCGTTCAACGTGGACGCCAAGCGCTACGACGAGACGCCCCTGAACATTGCTGGT TACTGCAACAGCACCGGGTCGGGCCAAGATAACTATTGCGTGATCTATTAAATGCAAATCGCACCTTTCCGTGGAGC CGGTGGCGGCGGTGGAGGCGGTGGGTCGTATGATCGCACCAACGACAACCTCTTCTCGCGTGACACCGTAGAACTGG TCTTGGGCCTGAGCATGGGTCCGATCCGTGGTCTGACCAACGGCATGAAGAGCTTTTACATCGGCGGCACTCCGCTG ATGTCGGAAGCCGGCAACATCAACTTTGAATCTTTCAACCTCGGCGTCAAGCTGGGTTATGAGTCCGACACGCCTGT CAGCTACAAGCTCGGCGGCGAGTCCTCGAACAAGCAAGTCGGCACGAAGATGGCGTCCAACTCCTGGATCACGCGCC AGACTGATGCCCCTTTGCGCGGTGTGATTGATCAGCTGCAAGTTCGCCTCACGGTGCAGCAGCTGTACTCCCAAGAT GATGATGGGATCTACAACAACACCGCTCGCTTCTACATTCAGTACAAGCCCGCCTCGTCGGGCTGGTGGCAGAACTA CGGCGGCGGGCTGGTGCAGCTTGAGGGCAAGACCCAGACTGGGTATTACGTCGACTACGTGTTCGATGTGCCGCGCA TCAACGATGACTGGCTCATCCGCGTGATGAAGGTCAACCCGGACAGCGACAACGACAATGTGGCCGAGATCGCCTGG GAGAGCTTCCAGTGCATCATCATTGATAGCGCTTTAAACGGAAGAAAAACATGAGTGATCCTATCAGCTTGAACCCT TATGCTGACCACATGGCCAGCTTGTTCAAGTTTTGCAATGATGTGCTGCCGAACCTCGGGTTGAACGCTGCCTCTGG GTCAGGAGCCGCTGCCGGCCCTGTGATCAATCTCGATGCCTACGGGGATAGCGACGAGCTGCCGGCGGGGAACTTGC TGGGGATCTCGAACTATGCCATGGATGTCGATGAGCATCTGGTCACGATCACTGTGATGTTTGTGGTGATCACCCAG AATGACCCGAACAACAGCATTCTCGACAAGTCCACTGGTCTTCTCACTTCCTACCTTCTCCCGACGAAAAAAATCCC CGTCGTGCGCGAGACTGACGGGGATGACGAGATCGGGGTCATGACGGTAGGAAACGGAGTGCGGGTATTTCCAATGT CAGGGGATCAAAATCGAAACTTCAAGATGATCGCGGTCGAGCTTAACTCAACCGTAACCCTCAACCTTTAGTCTTGT GATGGGCCTGTTTCAACTCGATGTCGCGGGCAACCGCGTTGTCGATGGCATGAGTGAGCATATGAACAATTTCGGCG TTGCGCGTGCGGTGTTGGAGCTTGGCCCGCTGCTCGATCTGTTCCTTGATGCTTACGGGAAGACGCAACGTGAAGGC CGCGTAATCCTCTTCCTTGGCAGTGGTGGTCATGGTTAGTTCCTATACCTAATAAAACCTTTGCTTGTTGAAGGTAT CACGATTACGATTCCGCAACCAGATTTTTAACGGAGAGCGACATGGCTGGTGAAGCTAAAACTGAACAATTCATGCT GGGCACGGCCACCGTCATGGTGGGTCCGATGGCCGATCTTTTCAGCTTGAACCCGGAAGAACATTCCATCGGTCTGG TGAAGAACTTCACCATGACCTCGGAACCGGGTTACACCGAGCTGACCCAAGGTGTGAAGAACACCACGGTCTACTCG GTGATGACGAGCAACCCCGTGCGCGCCACGATGGAAGTCTACGAGCACACGTCTCGCAACCTCGCCTATGCCCTGGG CCTGAACGGCGGCGAATACACCCCGGCTCCCAGCAACGTCTCCAGCCTGACCAACGCGGACATCGCGGGGGATCCGG CCGGCGTCTCGGTGATCCCCGTGGCCGACACCGCGTCCTTCCAGCCCAACATGTGGATCATGTTGCAGAACAAGGAC ACGGCCGACAACGTGTTCATCGGCAAGATCCTGTCCATCGACTCGACGGCCAAGACCCTGACGGTCGAACAGAAGAT CACCAACGATGTGCCGAGCGGTTCGCTGGTGCGCCCCTTCCAGCCCGTCGGCGTCGGCTCCAAGGAAGAACAGCCCT ACCTGTCGGCCAAGGTCGTGGGCAAGCTGGCCAACGGCAGCACCGTGGCGCTGCTGATCCCCAAGATGCGCATCACG GCCGGCTTCACCCTGGCTTTCCGCACCGACAACTTCGGCAACCTGCCGTTCACCATGACGCTGTACGATCTGGTGAG CACGGACGCCTACTTCGAGATGTTCAAGCCCTACGGGCAGGCGATGCTGTCGGCCCAGCGCTAAGGTTAATCTGGGT ATAAAAAATACCCTTGATGAACCAAGCCCCACGAGGCATACTCGTGGGGCTTTTTCATTGAGGATTCCTTATATGTC GAACCATCAATCTTCCACTTCGAAGCGCCCCGCGGATCGCCTGCGGATCACTGTGAATGGGGAGGCCAGGGAACTGT TCATGTCCTTCGGGCTGCTCAATGAGCTGTGCGCGCTGATTCCCGACGCCCACGCCGCCACCCAGGTGGCGCTCAAC GCCGACATGCGCGACGTGGCCCTGATCACGGTCTTGTCCCCCCGCGACGAGAACGGCCTGATCCCTGACCATCAAGT CTTCAACGTCAAGAAAATGGACATCCCCCTGGACGAGGCCGACCGGCTGCTCGACTGGGTGTCGGAGCACGTCCTGT ATTTTTTCTTGAACGCGCTTCGGAGGGCCGTGGCGGCGCAGGAGGGGAACACGGCCCTGAAGGAGCTGGTCGAGACG GCGAGGGCGGCCAATCTTCTGGGCGCAAACTCGACCACTTCACAAAGTGGTACGGGGGGCTGACGTTCCTGGAGGCCATCTGCTGGGCTTTTGATGCCGTGCCTTCGGAGATCCCCAGACTTTCCTGGCGGTACACCAAGCACGACATTAAAAT ACGCACCAGACTGAAGCTTGGCGAATGTCAAGCAAATCATGTGCAGCAGTACCAGACGCTGGCCTTGCTTCTTTCCC AAACCCTCAGCCGTGGTGAGACTGAGGATAAGAGACCGAAGGACATGGCAGACGCTCAGATGCAGCTGCACCGACTC TTCGGGAAAAGCAGATAATGGCCACCAAAAACCAAGTTGATAAAGGGCAAGTTGATATCACCCTGAATCAACAGGTC TTCGAAGACGTAAGGAAGCTTGAATCCTCGCTTCAAGGCGTCTTGAAGGTCTTGAACTCGGTAAGCTCCGCGTTCAA AGGAATGTCGATCCCGGGGGTGTCTTCGACGGATACTCGAAACGCCAACCTGGGATCTCAAATAGCCATCTTGACCC GTGAGGCCAGTCGACGCCGCGCCGTGAACAGCATCGGGCTGCAAACGCAGGCTCGCCGCGAGTTGGCCAGCCTGGAG AAGTCCCAGGTCGAGTATTCCAAGGCCTTGGTGGCCAATGATGAGCAAGCCGCCCGGCTGGCCAAGCAAGAGATCCT GAATGGCCGACAACGCCTGGATCAGCTGGAAACCGAGCTGAAGCTGCGGCAAGCCGGCGCTCGCGTGCGCATGGCCA ACGCCATGGACGCGGGCAACACCCGTGGCCAGGACACCGCTGCGGCCCAGCTGCGGGCCGTGCAAGAATCGATGGCC CAGGTGCGGGATGCCTCGCGCCAGAGCGAAAAGTCCATGCGGGATGCCGAGCGCGCTGCTGAAGCCGCCCGCCGGCA GCGCCGCTTGACCCAGGAACGCGAGGATAGGGCTGCGGAGCGCGTAGCGGCCTCGTATGGGCCGAACGCCCAGACCC GACTCCAGGCCCGGGACCGCTCCGATAACGCGGCTATGCAGGCCGCCTACCGCCCCACGCGCATGGCGGTGATGCAG ACCCAGCTGCTGGCCAACTATACGGCCACGCGCACGCTGATGGACTCCATGCGCGCCGGCATTCAGTTCACGCTTCA GTACGAAGAAGAGCTGATGCACTTGCGCACGATCACGAAGGCCACTGATGACCAGATGAAGGGTCTTCAGACCACGA TTGAAGCGGTGTCCAACACCACTCGATACAGCGCTGACGACCTGACCAACGCTGCCGCCGCGCTGTCCGAGACCGGG GTGACCATCAACCAGATGGCCGGCAGCTTGAAGGCTGTGTCCGATCTGGCCACGGCGACCGGCGCGAACTTCACGAT GGCGGTCAACACCGTCACTGGCGCACTGGGTGCGTTCAAGTTGTCGGCGAACGACACCGAAGACGTGGCCAACATGA TCGCGCAAGCGGTCAACTCGTCACGCCTGACGATGGACAAGTTGAAGACCTCCATCGAAACGGCTGGCGAGACGGCA AGTCAAGCTGGTGTGTCGTTCAAGGAATTCCTGGCCGCTGCGGCCACCATCTCCGACAGCGGTACTGGCACCGGCCA GACGCTGGGCAACGGTATGCGTCAGCTGCTGTTGGATCTGGAGAACCCGAGCAAGGGTCTGAAGGATGCTCTTTCGC GCCTGGGTCTCGTTGAAGAAGACATCAACGTCAAGACTCAAGGTCTGTACGGCGCTTTGATGAACCTGAAGACCGCG GGCTTCACGGCCAGCGATGCGATGAACGTGTTTGAAGCGCGTTCGTCGTCGGCCTTCAACGCCTTGAGTTCGAATCT TCAGAAGATGGAGCTGTTCCAAGAATCGCTCCTGAACACCGACGCGGCCACTCGCGCCAACGCGGACCAGATGGAAA CGCTGGGCGCGCAGTTCGACCGCGTGAAGAACCAGACCAACCTGCTGGTCAGCGAAGCCCTCAAGCCCATGGCTGTG GTGCTCACCAACGTGTTCGAGGTCATCGCTGATGGTGAGGGCAAGCTGAAGGAACTCGGCGCTGTCGTTCAGACGGT GGGCGCGCTGCTGGCCGGCGGTGCCTTCGCTGTGGGCCTGCGCTACGCGGCCTCTCTGCTGGGCGGCATCGCGGGTC TGGTTGTGCCTGGAGGAAGCATCCTTCAAGCTACGACCTGGGCTGCCGCCCTCGGTCCCATCGGCCTGTGGACTGGA GCCATCGCTGCTGCCGCTGCGGGCGTGGCCTATCTCGTCATGCAGTTGACCAAGACAGAAGATGCTTTCGAGCGTCA GCGCACGAAGGTCAACGAGTCCAAGGCCTCGTTGCAGGAAACGACCCAGGCCTATGACACCATCGGTCGTCGCATCA GCAACGTGCAAGACAAGATGATCGCCATGAATCGAGACACTTCCGGCGCGATGCTGCGTCGTGAAGTGAACGACGTG GCCAAACAGTTCGAAGAATACGGCGTGACGCTGGATCGCAGCGCGATCAAGAAGACCGAAGACATCGACGCTCTCCA ACGTCTGCGTTCCGAGTTGGGCAAGCGCTACGCTATTGATGCGTCCATCCTGGCCAATGACCTGGAAACGCTGGCGA TCCGCGCTCAGGAAAAGTCCGGCAAGCTGTCGACCGATCTGCGCGCCAAGCCCTTCGCCAATGGTCCCTTGGACAAG ACCCTGGCGCTGCCTCAACTGTATTCGAACTACTCGACGCTGGAATTCCTGATGGGTACGGCGGCTCGCACCGGCAA GCGTCTGGGCACGACGCTATCTGGCGGTAGCTCGGTGGGGTATATCCCGCTGCAAGAGAGCTTGACCACGGGCAACG TCCAATCCATCGTGCAGTACCTGAAGGATTCGGGCGTGAGCAACGCCGCGTCGGCCGGCCCCGGCCTGCTGGAAGCC TTCGGCTTGAACGGCAAGTCCAGCCCCAACGATGTGAACTCCATCGGGCAGGCGATCTCGGCCTTCAGCGAGCTGCG CCGCATGGCCACGCTGCAACGCTCCACCTCGGAACCCGACAGCATGGCTTTCCGCCGCGCCGAAGGTATCGCCCAGG TGGCCGAGAACATCATGGGCACGCTCAAGCTGGTGCAGCAATCCGTGCAGGAGCAGGAGAAGGCCACCCGCGAGGCC GATCAGGCGCGCAAGACCGAGGCCTCGGCGGTGTTCCGCCAATCCCCGCAGGCCCAGGCCCTGGGCAACGATGTGCA GGCCGTGATCCAAGGCGTGAACCGCGCCATGGCCAGCCGGGCTACGGGGGCCTCGCAGCCTTTCGACGTGCTGTGGG AAGCGGTCAAGATGGCCGAGAGCGGAGGCCGGCAGTTCGGCTCCGACGGCAAGCCGCTCACCAGCCCCAAGGGCGCT GTCGGCGTGTCCCAGCTGATGCCGGACACGGCGGTGGATGCTGCCCGCATGGCGGGTGTGGCCTGGGATGAAAACGC CTTCAAGACCGACGCGGCTTACAACGAGAAGCTGGGCCGCGCCTACCTGCAATCGCTGCTGACGCGCTACGGCGGCA ACCAGATGCTGGCCACCTCGGCCTACAACTGGGGCCTTGGCAACGTGGACAAGCTGCTGGCCAAGGGTGACCCCCGC GTGCCCGGCTCGGGCACCACCTCGACCGACTTCATGATGTCGCTGCCGGCTGAGACCCGCAACTACAACCAGCGCAC TGGCACCGCGGACTATGCGACCGGCCTGGGCGTGTTCGGAGCCTACAACCAGCTGATGGCCAACAAGGAAATGGCGG CAGCGCGCACCGCCGCTGGCAACAAGCTGCGTGAGCTGACCGCCATGTTGGAGCAGGCCACCAAGGACGGCAACGAA CAGATGGTCGACACCATCAACGAGCAGATCAAGATGCTCAATGAGGCCAAGACCGGCATCGACAAGGTGTATGCGGG TTCTCGCGCCGCAGCTGAACAGGCTATCAACCGCACGTCGACGGCGCAGCAGCGCAGCTACGCCGAGCAGATCGAGC AAGCGCGCCGTGAAGCCGCCAACGAGAAGGATCCTGAAGTGGTTCGTGCTGTGTTCGAGCGCATCAAGGCGCTGACG AACATGAGCTATGAGTCGCGCATCAAGGCGCTGAAGGACACCAACGAAGCGAAGTTCAACCAGGCTACCGGCACCTC CGAGTACACCGAAGACGTGAACGACCAGTTGCTCTCTCTGCAATCGCAGTTGGAAGCCGATCTGGCCAAGGAGACCG AGAACCAGAAGAACGAAATGGAGAAGCGATACAACATCATCGCTGGTCGTCGCACGACGGCTTCCATCCGTTCCGAG AACCTGGAATTCCAACGCGGCGCGCGATGTCTACTTCGCCCGCTTCAAGAAGTACAGTGAAAAGGGGGTGGCGATTG CGGCTGTCGCGGCCGAGCGCGGCCTGAACGTGCTGGCCCTGCACGAGATGGGCCAGACCGAGGCCATCAAGGCGGTTGTCTCGTGGATGGTGACCGATTGCGGCGTGTCCGACATCGAATCGCTTTGGATGACCTTCGGTTTCGCTGGTGGCAA CGCCAAGCGCGGGGCCAAGCCGCAAGCCCCTGCCGCTGACGTGCCCAAGGCCACGGTCAAGCCCGAGACCGAGCAAG AACCCCCCGCGCCCCTGGCCATCGCTACCGGGCCGGAAGCCTACGCCGCCACCATCGCCGCTCAAATGCAGGCGATG AGCGAAGAGGACCGCGCCATCTTCATCAAATCCCTCATGGCCCACATCGTGGATATGGGCTACGAAGTCCACGCCGC AGATACTGCGGTCACTGCCTAACGCCCCGGCGGGGCGGCGTCCCTGGTCGCCCCGCCTTTCCCCTACCCTCGCGGTA GGGGCTTTTTTGGACTTCTCTATAGGCGCGCCGCCCTGCCGTTGGCGGGGTAGCGCGCCTCACTATACCCGTTTGCG ATCAAGTTGGAATTGAGCGTTTCTAATTCCGATTTCTGATCCTCAAGTTCGTAACGAACTTTTCAAGTCTGGGAATT CGAAATCATGAGTTGCGATCCGACAATTGGAGACTACTCCAAGGTCATTAGCAGCGGCGTGTCCGCTCAACTGGCCT GGAAACGTGGTCTGGTAGTGCGTGCCCGCACCGAGCACCGTCAAGCGATTCTGAACCGGCAATTGATGCGGGAAGAG ATCCACCTGCTGGAGCAGAGTGGGGAGTTCGACTGGCTGGACGAGACCAAAGCGGTTGATAAGGTGCGCCAGCGCAA GAAAACGACACGCAAGCGCCTTGAAGTGGCCGAATCGGCGGTTATGCAGGAGTACGCGGCCCGTTTGCGCGCTGCGT GGCAAGGGTAAAAGTCTCGTTGTTACCGAATATTTCAACTTGACTTTTTAGGCGAAATGGTGTAGGCGTTGGCGGGG TAGCGAGTGTTGTTTTTCCGCCACAAAATGAGGCAGTCA

[0097] SEQ ID NO: 19 (exemplary genomic sequence for phiACH06) ACACCAAATGAAAACTCTGCTCGACCTTGCTAAAGCGATGGAAAAGCTACAGAAAGAAGTTTCGACGGCCGCTAATG ATGCGGCCGTTTTTGTAGCTGAAACCGTCGTCGAAAATCTCGCCCGCGTGACTCCCGTCGATACGTCTACGGCCATT TCTGGATGGGTCGTGTCACTCGTACATCAGACCGCATACAAGCCCGGAGCGCACTTCTACGGTAGTCAAGGTTCTAC CTATACGGCGTCTGTGCGTGAGACAATCAACAACGCGAAGCTTGTACTTCGCAATAAGCACCCCGGACAGAAAATAT TCATCGTTAACAACGAAGATTACATTAACGATTTGAATAACGGTTCGTCTAAACAAGCGCCTGCCGGTTTCGTTGAA CGGGCCGAAGCATTGGGACGAATTGCGATGCGGGATTATAAATTGAAACTCGACCTAAAGGTATAGCAATGTCCATT GCGATTGAAATTACCGATAAGGTTTCGGGCAATATCGAAAAGAAGATCGACGGAATTGCGCGTTCATCGCGTGAAGC CCACGGGGCCGTAAAGTTGCTTCGCGAAGCGCTTACGACGATCAACGATTCGGCATTGCGGCGCATGCTCGACACGG CCACCAGCAATACGGCCCGGTTGAACGCCGAAGCAAACAAGGCGGCATTGAGTGCTGCCAAGCTCGCGACGGAGCAA CAGAAGGCCGCTACGGCGGCGCAGCGCCTACAGACCGAAACCCAGCGCACCGCGAAGGCAGCAGCCGATGCAGCGGC GGCACAGACACGCGCCCAGGCAGCGGCCGACAAGCTCGCCCAAAGCCAGCAGCGGGCCGCACAGGCGGCTGACCGAC ACAGCCAAGGGTTACAGACCCTGAAAGGCTTGCTCGCGTCCCTGGGGCTTGCTGTGGCGTCCCGCGAGCTATTGAAA ATGGCCGACGCCTATACGAACCTGCAAAACAAGCTGCAAAACGTAGCAACGTCGCAAGCCCAGGTCAACGAAATCAC GAACCGAACGTTCGAACTCGCCAATCGCACGCGTACCGATGTGGACGCAACCGCGACGGCGTTCACGCGCTTCGACC GTGCGCTCAAGATCATGGGTCGGTCGCAAGAAGACACGTTCCGCATGACCGAAACGGTCAACAAGGGTCTCATCGTT TCCGGCGCAACTGCACAGGAAGCCGCACGTACCCTGTTGCAGCTTTCGCAAGCGTTCAACGCAGGCAAGCTGCAAGG CGATGAATTCCGATCCCTGGCCGAAAACTTCCCTATGATCATGGACGCCACCGCTAAAGCGATGGGCGTAACCGTCG ATCAGGTGAAGAAAATGTCCACCGAAGGGAAGATCACGTCGAAGGTGCTGTTCGACGCCTTGAAGCTGCTCGAATCG CAAGTCGATGCAACGTTCGCGAAAACGACCCCTACCATTTCGCAAGCCGGTGTCGTGCTGAAAAACAGCCTGACGCA ATCTGTCGGCGAAATGAACAAGGCGCTTGGCGTCACGAACTTGCTCGCACAGGGAATGCTGATTCTCGCGAACAACA TGAATCTCGTCATCCCGGCCGCTGTGGGCGTCGGAACGGCCCTTGTCATTGCCTTCGGTCCCGCATTGCTTCGCGTG CTGGGGCTGGCTACGAACGCGGTTCGCGTATTCACCGGAGCGCTTGCCGCTAACCCCATCGGACTTGTCGCCGTTGC CCTGACCACGCTGGTTACGGCGCTGGGAATGTACATCGAGCGCACCAAGGCCGCGACCACTGAAACCACGATCATGC GCGACTACATGGTTGCCGCATTCTCGTACGTGGCCGATGCCTGGAATGCCGTCACGAAGTTTTTCGGCGATGCCTGG GATACCGCAGTCAAATACGTCACGGATGTTTTGGCCGGATGGGGAACCACGTTCGACGAAGTGTTTTCCGCCGTAAC TACCGGCGTGAAACAGTACGCGAACCTGCTCGTCCAAATCTGGCAAGCGGCGTTCGAAACGATTTCGTTCGTGTGGT CGAACTTCCCGGCGCTGATGAAGAACTTCTTTGTCGCCGTCTACAATTTCAGCGCTGGCGTTGTCGAAAGCGTCGTC AATAGCTGGCAATCGGGAATGAAGCTGATCGCCGACAGCATCGAATCGTTTGCGCCTTCGGCTGCTGCGGGGATTCG CGAAGTTCTCGAATCTACGCGCCTCGAACTGACCCGGCTGGAATACGACACGGGCGGCTTGCAAGCTACGCAAAACT ACCTCGACAAGATGAAGGATATCTTCGCGGGCGACCCCATCGGTCAGTTTGCCGATGATTGGGCGAAACGCGCATCC GAAGCTACGTCGAATCGTTTGAAGCTGGCTCGCGAACAGGCCGATTCGTTGCGTGGCGCTGGCCCTGCTGCGCCCAC AACGCCCGATGCAGGCAAGGCGAGCAAGGACGCCAAGCGCTACAAGTACGCCGATGCGCTTCGCGAAATGGAACGCG AAATCGAACTGTTGAAGATGACGCGAACCGAACGCGAAAAGCTCGCACAGTTGAACCAGCTTGAAGACAAGCTTGGC AAGGACAAGCTCGGCAACGTGATTACGTTCAACGCCGAACAGAAGAAAACGTTGCTCGGAATGATCGAGGAACAGAA TCTGCTGCGCAACCGTGCCGCAATGCTCGACGAACTGCGCGGTCCTGAAACGGCCATGCTCGAAGGCCAACAGGCGC TGAATTCGTTGCTGTCCGACGGCGCTATCACCGCCGAAGAGTACACGAACAAGATGCGCGATTTGAATCTCGCATTC CTCGAAACTCAAACGACGATGGAAGGCGGATTCCAGCGCGGAATCCTGAAAGCGCAAAAGGACATGGGCGACCTGTC GAAGCTTACCGAAAACTTCGTCACGAACGGGGTTCAAGGGATGGAAGACGCATTCGTCGAACTGGCTACGACCGGCA AGATGAACTTCGCGAAGTTCGCCCAATCGATCATCAGCGACCTTGCCCGCATGGCTGTTCGTGCGTTGATTACGCGA GCTATCCTCATGGCTATCGGCGCGATTTCAGGTTCGATTGGCTATCAGGGTCAAGGTATGTCGGCGATGGGTTCGGC GTCAGGTATGGGCGGTTCGCTCGAAAGCTTCATGTCAACCGGCGGCGGTTTCTCCAAAGGCGGTTGGACTGGCAATTCGGCACGCGATCAAATCGCAGGCGTGGTTCACGGTCAAGAATTCGTCGTCAAGGCGGGTCCGGCTTCGGCCAATCGT GAATTGCTCGAAGCGATGAATCGCGGTCAAACCATGACCCCGCTTTCGTCTACCGATGCGACCGCCGCTTCGTCTGC GCCTACGTCGTCCTTTGCTTCGTCGGGCTACCCGTCGTCGCCTGTGGGCGGTCAGCGTCAGCCCGGTTCGGTGGTGA TTAACAATTACCAATCGGATAAAATCAAGGTCGAAGCGCAGCAGACCGAAAACGACGACGGTTCCATGAACGTCGAT GTTATGGTCGATCTTATCGAGGGTCGCATCGCCGATAAAATGTCGGCGGGTATGGGGCCGATGTTCAACGCAACGCG CGACCAATTCGGATTGCGCGCCGCACCTAAAGGGGGCTAACTAAATGGCGGCAAAATTCCCGCATGACATTCTACCG TACCCAATACGGGATGGATACGCACGCGATGCCGCCAATCAACACCAAATCACGAAGATGGACGACGGCCATAATTT GGTCCGTCGTACATCCAAGGGCTTGCGACTGAAAGACGCGTTCACATGGGTCTTGAACGATGATCAGTTTGCGAAGT TCAAAGCGTGGCTTGCATACTCAATGCATGGCGGTATTGATTGGTTCGACATGAAGGCGGGCCCGAACGAAGAGGAA CAGACATACAAGCTCATGTCTGAACCGAAGTTCGCCTACGACAAGTCGCGCAATAAGTGGCGAGTCAACGCCGAAGT CGTGTTTCTTTCGAAGGCTGCACAGCAAAAGCCAAGCGTGTTTCTTGCACGATGGCCCGATGCCCTACCCTGGCCCG AAAAGGACGAACACAACGTCACCGCAGAAGACTACATTACGGTGGACGAAAACAGCGACAACGGCTTACCCGAATCG CGAGTCCGATTCAGTGAAAAGTGGACGACGTTCACTAACAAATGGATCATGGATGGCGAGCAAAAACTCGCATTCGA ACGATTCCTGTCGGACGATATCGCATTGGGGGTCGCATTCTTTCTCACGCCGTACTACGACGACCAGGGCGAAAGAC GAGTAAAAGCTCGTTTTCTCGAATACCCCCGATTCCAACCTATCGGGGCGCTATGGGGCGTTACCGCGAAACTCGAA ACGCGTGAAGCGGGTTTGATGGACCTGGGCGACTGGAACAAGGAAGTCTTCGCGCCCACGTCGAACTACGCCATGGG CGTTGAAATGCATACCGAGAAAACTATCGGACTCATACTCGAAAGCGGGTATCAGGTCGGATCGGTGATTACCGGGG TAGACAACGAAATACCGGCCGCATCTGAATTCCTGGCTGACGTGTCGTTGTATTGGGAAATTGGTAGCAGGCTCGCA ACGTCTTACGCGATGGCTATCGATGTAACCGTCGAAGCTACGGTCGCCGACCTTCGAACGGGTTACGCTACGGGGGT TGACATTGGCTTGGATTATGGCGTAAGCCTGCCTGACGTGTCATACTCCCAGGGGGTCGCGATCAGTGACATTTCGA TTACGTACGAAATCAATCTTGAAACTTCGTACGCAATGGCTGACACCGATTACGGCATTGTTGAAAACGACGGTCCC ATACTTCGCGATGCATATCGAATCGAAGACACCGGGAACGCTTACGCATCGACCTATGTTGTCGGCGGCTACTGGCC GGACGATTACGCAGGCGAAATCATCCAAATGAGGAACTAAACACATGAAAAACGGCTACGATCTTTACGGACACGTC ACCATCGAAAAGAACGGTGTTGTCGTTCTCGAACAAAAGAATATGGTCGTCGATAACGGCTTGAAAGCGGTTCAAGC ACGACTGTTCGGCGATACCGTTCCGGCCGTGCGCTACATGGGCGTCGGCTCCGGCACTGCGCCCACAACGGCAGGTA TGACCGAATTGGGCGCACCGCTCGCGCTGGCCGGTGGCGGATTCCGCAAGCAATTCGACAGCACGCCGACGCAAGCC AACAACGTCACGACCGCAGTGACGACCCTGGGGCCGGGCGATGCGACCGGCAACATCAACGAAGCGGGGTTGTTCTA CAACACGACGGGCGTAGCACTGTACGCCCGTCTGTTGCTCGCGACCCAAATCATCAAGGGTCCGAACGACACCATCA AAATCACCTGGGTCATTACCGCAACGCGAGCGTAAGCCATGGCGACTACTCCGTACCTTCCTAACGGTATGGTGATT CGCGGGGATCAAACATCCCCGCTTACCCAAACCGAAGTAGATTTGAACTGGCTGTCGTTGCGCGGTGGCGGGATGAT CTACGTTCCCCGCGATATCGACCTGAACTTGCTGACGACTCCGGGACGCTATTATTGGGTCAATGGCGTCCCGAACG GAAACGGCTTCCCGCCCGGCCTAGCGACGTTCGGAATCATTACCGTGGATACGACGCCCAGCGACCCGAACCAAGGT CCGGTAACGACGTATCAGCGCATCGAATCCTACGCGCTGCGTGCCGGTGCGCCTACCGTCGTATACGCTCGTCGCAT CGTTTCCGGGACTCCGACCGGATGGCAAGCTAAGATCGTCGTTGAAGCTTTCAACGCGGCCCCTACGGCCAACATGG GTCCGGTGACGGTCATCAATGCCGACGGTGAATTCTCGATGATATGGGAATCGTCGCTAGGCCGATACGTCAAGGTC TACGACGGTCAATACACCAAGGAATTCACAGCGAACAGCAGCGAACAAGGTTCGTGGACAACCTCGACGTACTTCTA CTACTTCTACCTCGAAGTCATGATCGGCGGCGGTGGTGGCGGTGGTGCAGGATACAGTACCGCAACGGGCCAAACGG GTTGCGGCGGCGGTGGTGGCGGATCGGGGAACTTATTCGTACCCCGACGCTTCACGCACGATTTCGCGCAAGGGCCG CTACTGTACACCATCGGGGCAGGTGGACTCGGGGCGAAATCTGACGGTAGCGCGGCCGCAACCGCAGGCGGAAACAC TACCCTATTGGGGACCATGACCGCCACGGGCGGCCCTGTGGGTACAAGCGGGTCATCGGCCTTCGAATACGGCGGTC AGGGTGGCGGCAACGGCTCCGGCCCGGGGTCGCTGCACCACGGCGGCTTTGGTGGTCCTGGCCTACAAGGCTACGTC ACTAAGGGCGGCGTGCTTCGCGGAAACAGCCCGCAAACCGGCGACAACGGTTCGCTGCTAAACTATGGCGCTGGCGG CGGTGGCGGTTCCGGTAAAACGGTCAATACCTCATTCGCAGGCGGCGGCGGAAACGGCTCGCCGGGATACATCCGCC TTCGTTATTAACCTTCAACAGACGGGGCTTCGGCCCCGCATTCATTATGGCAAATAACGCATACAGTGAAGCAATCA AAGAAGCGTATGTCATGGCTCCGGCCGACGAACTCGTCTACCACACGCTTGAAATCCGACACCCTACGTTTCGCGAC GGGAACAATCGACAGACCGCAATTCGCGTCGTTCAAGGTAACGATGACGTAATGCTGCGCGTCGAAGCTGGAAGTAC TGGACCGAACCCCGGTGAGGTCGTTCAATGGCTGGCGTGTAATTTCTCGATCACACTGCCCAAATCCAGCCGCGACG ACGCGCCCGAACTCAACATCAGACTTCCGAACGTTGACCGCGAAATGGTCGGCTACATCGAACGGGCTAACGCAACG CTCGATCCGATTATCGTCGTGTACCGACCCTATCTGGAGTCGAACCCCGACGAACCGCAGATGAACCCGCCCATCGA AATGAAGCTTGCGAAAGTCAAAGCTGACGTGTTCAGCGTGACCGGCCGCGCAACGTTCGATGATTTTCGCAATCGCC CGTTCCCATTCAACAAGTACACGCGCGACGTGTTTCAACGCCTATGACCCCCGAACAAGCTATCCCATATCTCGGCC TACCATGGAAGATCGACGGCAAAGGGCCGGATTCGTTCAACTGCTGGTATCTGCTATGCCATATCCAACGAACCTAC TTCGGAAAGGAATTCCCGCAAGTGGACGTAAGCGATGGCGAAGAATGTGTTCGCGTACACGCCGAATGCCTCAAATC CGGCGCATGGGAAGTCGTTGACGTTCCGATGCACGGCGACGGTGTTGTCTTGAAAGGTGGACGTGACCCGCACGTCG GGGTATACCTGGACTTCGACGGCGGCGGCGTCCTGCATTGCCAGGAAAACGACGGCGTAATCTTCACACCGCGACCG GCCCTAATCAGCATGGGATACGGCCGCGCAACCTACTACCGAATCCATAAATGAAAAAGATTCCTAGCGTTAACCTA TCCGATAACGCGTTGAATCCGTATGCGAAGCAAAAGTTCGTGCAAGTAAAAGCCGGACAGCGCATCAGCACGGTACTTCGCGAAATGGGCTATCTGACCGGACGCGGTGCGTCCGCAAAGCGCTCGCATCCGTTCTACATCGAAGTGAACGGGA AACCCGTGCTGTACGAAGGCTGGGGTTATCGAATCCGCGCATCGGATACCGTGAACATCGTCAACTTGCCGAAAGGC GGTGGCGGCGGATCGAACCCGCTGCAAATCGTCATGATGATCGCCGTCGTAGTGGCCGCAATCTACACTGGCGGCGC TGTGGGCGCTGCGTATGGTGCTGGCTACGGCGCTGCCGCCCAGGCGGGTGTTATGGTCGCCGGTATGGCGCTGATTT CGCTGGTGACGCCTACGCCGTCGCTCGGTACGAACATGGGCAAGCAAGAAACGTCCCCGACGTACAGCATCAGCGCA CAAGGGAATACCGCACGACTCGGGCAAGCGATCCCCGTATCGTACGGCGAAGTGAACCAATTCGCCGATTACGCGGC CGCGCCCTATACGGAAATCAACGGCTCCGAACAATATCTGTACCAACTGTTCCTGTTGACGCAGGGGCATACGCAGA TTAACCAAATCTTCATCGAAAACACCCCCGTGGAGCAATTCACGGGCGTTCAGATGCAAGTGGTTCAACCGGGCGAA GCTGTCACCCTGTTCCCCTCGAACGTCTATACGGCCCCCGAAGTGAACAACAACGAACTCGTCGCCCCAAATCTTGG CGGAACGATGGTCGGCCCGTTCGTCGTGGTCCCCATCGGAGAAAAGGCGAACGCGCTAGGCTTCGACATTTCGTTCC CGCGTGGCGCTTTCCGAATGGACAACAAAGGGAAGCAAAAGTCGCACAATCTTTCCTACATGATCGAATACCAACGG CTTGACGACACTACCGGAAACCCTGTCGGTAGCTGGATGCTGGTTGCGAACGAAACCGTGACTTTCAACACGGAACA GCCGCAGTTTCGATCCTATCGTATCGACGTAGAACCGGGCCGCTATCAAGTTCGTGCAATCCGCCTTTCGTCCAACG AATCGAACAAAGAAATCGGTGAAATCCGCTGGACTAACGCCCGTTCGTACATGCCCGGATCGCAGCGCTACGGCGAC TGCACGTTGCTTGCGATGATCATCAAGGCAACGAACCAAATCAACCAAAATATCCAACGTCGGGTTCGCGTGAAGCA TACTCGCCGCTTGCGTACGTGGAACCCTGTCGATGGGTGGTCGGCAGCTTTGACGCCCACACGCAACCCGGCCTGGG CGCTGGCCGATATGGCGTCGAATCCGATCTATGGTCCTGGCTATGGCGCGTCGAAGATCGACATGTTCGAACTGTAT CGCCTGTCGCAAGTATGGGCGCAACGCGGTGACAACTTCGACTTCGTGTTCGACGGTCAAATTCAGTTTTGGGAAGC CCTTAGCGTAGCTGCCCGCGTCGGTCGTGCGTACCCGCTGATGAGCGCGGGCATGTTGTCGTTCGTGCGCACCGAAG CCAAGACGATGCCTTCGTTCATGTTCTCGCCGAACAACATCGTGAAGGACAGCTTCGACGTTGAATACTCGTTCAGC GATGGCGTTTCTACCCCCGACTATGTTGTCGTGGAGTACACGAACCCCGAAACGAACCAACCTGAAACCGTCAATTG CATCTTGCCCGGGATGAAGGGCGAACGTCCCGGTACGCTCAAGCTGCTGGGATGTACGAGTCGCGATCAGGCATGGC GCGAAGGCATTTCGCTTGCGGCCGCGAACCGTGACCAGCGCAAGATCATCAACTTCACCACTGAACGTGCAGGGTCG ATTCCCCGCGTCGGCGATCTTGTGCGCGTGTCGCACGACATGCCCGCATGGGGCTACAGCGGTAAGGTGCTGGGCTT CAACCCGACTTCGGACACCATCGAAATTCATGATGATCAAGGCAAGGTCATCGATACCATGCTGCCGTTCGAACTTC GCACGACCGAAGATATGCCTTTCCTTCCCGGCATTCAACACAGCATCGCTTTTCAGAAGCGAAATGGCGCGCCGGAT GGCCCGCATCGTGCGTTGATTCATCCCAGCGGCGACCGCAAAAAGTGCATCATTTCTACCGCAAATCCGCGCTCGAT TTACATCAGCGATGGCGTCCGCCAGGAAATGACCGGCTATCAATTCGGACCCGACGAACGTCGCGGTTTGGCCGCAA TCGTCATCAGCGCCGCGCCCGATGAAAAAGGTCGCGTGCGTCTCGCGCTGACGAACTACGCGTCTTCGGTACACACT GCTGAAACGGGTAGCGCGCCTTCGCCCGGTCCCGATTCGAACTTGCCCGAAGCTAACGCCGCGCCGATCATCGATTC GGTTCGCTTCGAGCCGTCCGCGTACAGCGGTGAATATTTCCTGCGCGCAACTCCGGCGAACGGCGCGTCGTATTACG AGTTTCAAACGTCGGTCAACGGTACGCAATGGCAATCGGCGGGAGTGTCGCCCGATCCCTACATGAAATTGTACCTG TCGCCCGGTACGTATTGGGGTCGTGTGCGTGCATTCGGTCGTGCTATGGGTCCGTGGGCCACGACGCAACAGACGCT GGACGGAACGGTACTCCCCATTCCCGAAATCATCGCCGCAAGTGCAACGCAAAACAACTTCGATACCATCGTGTTTT CCTGGGTCGTTGATCCCGACATGGAACACGCAGTTTCGAAATTCCACGTCTACTACAGCACGAACGACACCGAACGC GAGTCTTCCGTTTCCGTCGGTTCGAGCGGCCGAAGCTTCACGTATCACACCGAGAAATTCGCGTCTGAACGATGGTT TTGGATTCAGGTCGAAGACACCGACGGTCGGCTCGGCCCGATCAAAGGTCCGTACTACGGCAAATCGACTTCGGACG CCAATTACGCACTCGACATGCTCGAAGGCGAAATCGGTCAGAATCAATTCGTTCAAGCGCTGAACGAAAAGATCGAC CGTATTGATACGCTGACGGGCGACGTTGCCGGACTATGGGCCGGCATCGAACACGAACGCGATGCACGCGTGAACGC AGACAACGCGCTCGCCAAAGACATTCTCGATGTGCAGGCCGGTGTGGGCGAATCCATGGCGGCGGTTCAAGTCGTTG CGCAAGCTCAAGCGAATTTCCAGGGCAAGTTGGCATCGAACTACGCCATCAAGGTTCAGGTGGACGCTAACGGCAAC AAGTACGCGGCTGGCATGTCGCTAGACGTGTCGGAAAGTGTTGGCGGCGACTACCAATCGACCGTCGCATTCGTGGC CGACCGATTCGTTATCATGAACCAAATCGGCGGAACGCTGCAATCTCCGTTCATGGTCGTGAACGGTCAAGTTCTGA TCCGTCAAGCGCTGATCGGTGACGCGTGGATTACGAACGCGCACATCCAAAACGCAGCGATCACGAACGCCAAGATC ATGGATGGCCAAATCACCGCCGCGAAGATTGGCTATGCGCAAATCAACAACACGCACATCGCCGACGCGCAAATCAC GATGGCGAAGATCGGTGTTGCGCAAATCGATACGCTACGCCTAACGTCAGGTGCAGTGACGACCGGACAATCGTTCG GATTCTCGATTCAAGTCGGCCGTAGTAGCGGCACCGATGCCTACGCGTACGCCGTGTACATGCCGTACGGCGGAACC GGGATGATCTTCATGAACTATTCGTTCGTGGCCGATTGGCAAAACTCGCGGTGCTATGCACGATGCGATACCGACGG CTATGTTTTCCTGGATAGTCAAATGATATTGACTTCCGAAGGTAAACCCGAATGGCAGCCCAATCATCGAGCTAGTT ATATCACCGCTACTTACGGATGGGCATTCAACTTTCAAGTTACGGTATGGTGCCAACGTCCGGTCAACGGCTATAAT TACTACTCCGGCCGAATCGCCATGCTAGGACTACAACGATGAACATGAACATGATGATCCCCGGCCCCGCCGGGGCC ACCGAATACGCCTTTGCACGGGTTCACGAAGGCTTTATCGTAGGCGTTGCCAACGTCTACGGCGAAGCGGCGGCAGA AGCCCACAGGGCGCGATTCCCCCAGGATATTGAATGCCCTACCACGGTCACGCCGACGGGCTGGCACTACAAGTACG GACGTTTCGAACAGAAGCGCGTACTCGGTGCGATGCTGCGCGGTAACACCCTGGTAGGCATCGCATCCCCGTGCTAC ATCGTGGTGAACGGCATCGAATACGAAGTCGAAGCTGGCGTAACCGAACTCGAACTGAACTTCGATGCGCCCGGCAA GTACGAAGTCCGAATCACCATGAACCCTGAATTCTTCGATGAGGTACACACAATTGAAAAAGTCGATTAACGTAGAT TGCGGCTGCTACACGAAGCGCCGTCGCAATGAGTATCCGCCCATCGCCGAACAACTCGACGCACTCTATTGGGCCATCAAGGACGACGCGGAACTGTCGGAGCGATTTCAGGCGTTTCTGGCGCCTATCGACAAGGTGAAGGCCCGACACCCCA AGCCCGCCAAATAAAACGCGCCAGCGAGCAAACAGCCCCGTTCCCGGGGCTGTTCTTTTACCAACTTTCTTCTTTCT CGTCCTGTACCGCGTCGAACAGGTCTTGACGCTTGCCTGACCGCTTGCGACCGTAGTAACCCATGGATGCAAGCATG TCTTCGGTCATGTTGATGTAGTCGTCGTACGATACATCATTCGGGAAGCTATCGGGCCAGTCCATGCAAGGCGTGGC CCCTTCCGAACCGCTTACCCGGTTGCCGTTGCTGATGTATTGGATCGGTCCAGGCGAGTTCGTACCGTAGTAGTAAC GGATAGCCTTACCGAGAAACACCCCGTCCTTTTCGGCCCCGCCTGCGACGTTCTTAACGGTAATGAAGTCGGCCAGA TTCTTGTTGTTTCGGATGAACGATTGTATATCGGTGTCGTTGATGAGCATTTCGGCGATGGCCTTAGCGCAAACGTC CGCTGTGGGCTGTTTCTTGATCGACGATTCACCGAACACGCCCTTACCCTTGTACATGTCGTCAACCTTAGTTCCTT CGGGGAACGTATCGACCCATGATTTCGAACCTTTGTCGAAGTGCTTTTTCAACGCGATGTAGTTGTTAACGTCACGC GACAGCACGGCCTTGTATTGGGTTTCTTCGGTTTCGAACTTCGTCAACTGTTCCCAGCCGGCCACGATGGAATTGAC CATGTTGTATTGCATTACGTGCGGCATGATGACGATGCCGTCCGTATTGGCGGAAACGACCTTGACCCCGTTGAGTT CGAGCATTTCGATCAGCATCAACAACGACAGTTGGCCGGTTAGCGTGACTTGTACCAGCAGGTTAGGCGAATAGAGA TTCGAATACTTCGAACCCAGCTTACCGAACGATCCGTTAATCGTAATCTTCAAGCTATCGGCAATGATGCCGTAAAG CTCGCGCTGATCGAGTTCGCCGACCTTCGACAACCCCTTCGCTTCGAGTCGCTTATCGACCAGCTTCTTATAGACGG TGATAAACGTAGCCTTCAAATGCTCCGGGAAGAATCCGTTGTTGATGATAATGTTCGGATAGTAGCTCGCAACGTCG CGGTCGATCAGTAGGTAGCCATCTTTGGCCCATCGCGCAACGCATGATTCGGTGGAGTGCAAGCCGCCGACGCCCAT CTTATAGACGGACTCGTTGATCGTGATTAGCAGCCCTTTAAGGAACTCGCATTTCGGTTGGCCCTTGTCGCTGATAA CGAACGGGGCGCGCTTGATCCCTTCGAAGACGCGTTGCATCATCGGGGTTTGGAAATGGATAAACGCCGGGGGTTGA TAATAGAACGTCGTACCCGGCGCGATGATCGGCTTCTTTGCGAAGTATCCGTTAATCTTTGCGCATTCCGCCGTCAG GACGTGTTCGGCAATCTGTGCGTCCGAACGACTACGCAAGTCCTGATCGTATTCTTCGGACAACTGTTCGCGCAATC GAATTTCCTTCGACAGCTTATTGAACAGAAGTTGAGTGTTCGTAAGGTCGTTGACGCAATAGTACAGGACGTGCTTT TGCTGTTCGAGCGTCAGCACTTCGGCCGGATCGTACGGCAAGTCCTGCATACGCTTTGCGTGCAGCCGCCCCGCCAG AATCTTCAAAGACGGTTTCAGCGGAACAAGCTCGATGAGGTCGATCATGTTGTACGACGGGAAACGCAGGTTGAATT CTTCCTGAATTTCGCGCACGCCGTAGCGGTCCTGCGACTTGTTCTTTTTGTTCTCGCGGGAAGTGTTGATCATTCGA TCCGCGACGTACTTGATGGTCTTATAGTCGAAACCGTACACCATCAGCCACATGAGCGGCGTATCGAAGAACTTACC GTTGAACGTTACGTGACGGAACGACCCAATGATCCAATTGAGCTTTGAACGCTCAACGTCGGTCAGTACGGGCTTTT GTTCGTTCTGTTCGAAGTAGACGACCTTATCGCTTGCCACGTCGCGAAAGCCGATGCAGCAATAGTTCGGATACGTT TCAATGTCGTACACGAAGGTCGCGCCCGTGTAGTGGCGCAACTCGTCGTCCGTCATCAATTCGAACGGAACCAATTC GGGGATGGGATAGGTTAGCGTCTTGCGGACGAAAGGGGCTTTCGCCCCCTTCACCTTGCTACGCGGATTCGACGCCA GATTCGAATCATCGAAAAACATTACGTGTCCTTGATGCCTACGATTGCCCCGCGAACATTCGAACCGTTCGCGAAGT ACATTACGCCAGAATTCGAAGTCGTGATATCCCAGCGTTTCAGGAATGGTGCGCAATCAGCGATTGACTTCGCACTA TAGCCTATCCGCGTGCCTGTGGGCAAGCCGTCGAATTCTTCCTGCCCCTGGCCCGAGCCACGCGGCCCGGAACTGAT GGCCTTGTCGGGTTCGGACAAGTATACGTCGCCGTTTTCGCTGAACGGTGCGATGCGTGCGACACACTCTACGAACC CTTCGGGTAGATCGGTGTACGTCAGCTTTTCGAACTTGTCTAGGACGATGCTAGGTTCGGGCCAACCTTCGACGAAA CGTTGACATTTCAGGAACGCTCCGTTCGAATAGTGCAAGGTGAACGTGCCGACACTGAACCCAAATCCGACCACGGT TCCGGGCATCTTCGCGGCCACCACTGCAAACGACTTCGGCAAAATAAGGCTTCGCGGCAAATGCGTACCGTGGTACG CCTGCAACATAGCGTTGCCGTTATATGCCGTTACGGTCCCTTCGTCGATGTACAGCGATGCCATCAGGACGCGGGCG GCACCTTCGGTTGCCAGGACGCCTACGGCAACCATCGTATCAATCAGGGCTTGCCCACACGGGCCGACGTTTGCGTC AGGTAGCGGGCTTGCCATGTCACGCGGTAGCAAGCACGGAACCTTTGCGCGGAACTTGCCGGACTTGACCGTAAGGG TTGTCGGGTCGGTTAGCGTAAGCGTGAAGTTATCCCCGCACGCCTGCATCGCTTTCAAGAACAGTTTCGTATTCGGG CAAGCGATGAAATCCTCTTCGATGGGCATTCCGACAGTCAAGACGCCATCGTATGCGATCATCATTCGGTTATTGAT GACGCAATGCGTTTGCGAAGGCTGATCGCCACCGCCGCGCTGGGCAAGCGCGACGATCTTAGCGGCTTCAACCAGGG CAGCTACGCGATTGTTTTCGGCCGCTTTAGCTGCGCGTTTGCGTGCGGTTGACATTATCGATTTCCTGAATTGCGCG TTGCAGATAGTTCACTTGATCGAGGGATTCTTCCAGCGCGTGTTGCAGCCATTCGCGCAGGGTAAGGGGGTTGTCCG CCAGGGTCGTACCGTACTTGTTGATGCCGACGCGGGAACGGTTGCGCAGCATGGCGACGTTTGCTTCGACCACCGGA TCGGCGCACGCTTCGTTGCGGGCCGTCACGTCGTCAGCCGGTACGTGCGGCGACGGTGGCGTCACTTTCGGAACGCA TTCCAGGCAGTAGTACGACTTGATTTCGGGATTGCATTTGCACATGATTTCACCTTAGAACGGAATGTCGAATTCGT GTTGCTCGCAACCATGCACGATAACACGCGACGGGGGCATCTGTCGATACAGCTTGCATCCTTCGGGGGCCGTGGAC GTACCAGCTTGCCAGTTGGCGCAGTTGAGGCAGTTTTGCAGGTACTGCGCGGCGTCAGCTTTACGCTGGTAGTGAAG GCGGATTTGCTGATCGGTCAACGCTACGGGCATTTCTCCGACCGGCGTTTTCAATACCTTATTGGTGGAACTCATGT CTTACAATCTCCGGGTAGGGCCGCTTGTTCGTGTGAACGTGAATAACGGCGGGGGTTTTGAAAAGGGTAGTCATGCT CAATACGTCGGCGGTCGTAGCGGGTACGATGTGCTTCCCGGTACGTTCACGATACCACCATTCAGCTCGCTTGCGTG CGAAACCTTGCCCTTCGAACGCGATGAATTCGTTGTAGGACTTGCCGCGACAGTAGTACGTAGCCTTCAACGTCGTC GGTCGTCCTTCCTTCTGATGCGGCGAGTATAGCACGCGAGACACGGGCAATTCTTCGATGATCTTTTCTTCCATGAC CGACATGAGCGCGTGACCCGTGTTGCTAAGGTCGATACGCAACTCGTTATGGAATTCTTCGCCGCATCCTACGACAC GCGTTTCGATAGGTCCACCGCAAAAGCGAGCCGATGCATGGTTGTACATTTGACACTTCGGACAGATGCGGACGGGG GCATCGCCGCCGCCTTTACCTTTCTTGTTCGGGATTCGCGGATTGTCAATCGGTCCCAATTCGAGGATGTTACCGGCGAAGTCGAACACGAAGCAATTCGTTTTCAGATACTGGAAGTAACGCGCAAGTTCTGCGGGGGCTGTTGCGGGATCAT ACGGACGAGTGCCGCGACCCAGGATTTGAACCCATAGGCCAGCGGACATGGTAGGGCGGAATATGCCGAGACTATCG ACCGGCCGATGGTCGAAGCCTACGGTGTACTTGTCTTTGTTGATTAGATAGCGATGTTCGCCGCGCTTGAATTCGGC CATGCGGGCGTCAATTTGGCTTTTCTTCAACTTCGAATGGATGACCGTAGCTGACGCGCCTGCGGCTTCCATCATGT CGCAAATCATTTCGGCATGTTTGATCGACGTTGCGAACGCCAATCCGCTGACACGGTTCGCCGTCCCTGCGAGATAT TCATCGACGCAGGCTTGCGTTACCGCTTCGTTCAGCGCCACGGTATCCATTGATGCCTCGGTGAAGTCGCCACCGCG AACCTTAAGATTCGAACGGTCGTAGCTCGAACGAGTAGGGCCAGATACGAGCGGCGCAAGCCAGCCGTTCTTGAGGA ACATTTCGAAGTGCGCGGGCGTCGTGCAATCGTAAATGATCGTCTTGAACACGCCGCCGCTAGTAAGCATGCCCATG CCCATGCGGTACGCGGTTGCGGTGAAGCCACACAGGTTCACATTCGGATTGATTGCGGTAAGCCCGCGAATGATTTT CAGGTAGTCGCTATCAACCTTATCGGAAACGTCCTGCGCTTCGTCAACGAGAATAACGTCAATATGCCCGATAGCTT CGATTCGGCTAACCACAGTACCCGGAGAACCGACGATAACCGGATGGGCCACGTCAGTACGATTCAGCCCGGAACAG CAAATCCCCACGGGGATGTTCGGGTTCATTCCGGTGATAGCTTTAGCGTCCTGTTCAACAAGATCGCGAGTCCCGGT CAGGACGAGAAAACGCATGGTCGGATAGAGTCGCATCGCGGTTTGGATGATGGACGCAATGACCGGACTTTTCCCCG TCCCTGTGGGCATCAGGATAAGCGAATGATCTTTCAATGCGCGTTCGATGTAATGAACGAAGAAAGCGTTATGCGCT TCGACTTGATACGGACGTAGTTGCATTTTCGGATACTGTGGTTAAACGAAACGGGGGTCTTTCGACCCCCGGATACT ACTTCACTTCGGCGGGGTTATTGGCCCCAGGACGGCTGGCCTTGCGGCTGACCCTGCGGCGCGCCCCATTGCACCGG CTGCTGTGCCTGGGGTTGCGGCTGGGCCTGGACCGGGGCTTGCTGCTGGACCGGCTGTTGCGGCGCGGCTTGCTGCT GTTGCTGCTGTTGCTGCTGCACGGGCTGGGCCTGGGGCTGCTGTTGTTGCGGGGCAGGCGAACCCCAGCCACTCGCG GCAGCAGCCGACGGGGACGGCGTGACGGGCTTGGCGGGCTGGCCGGGATTGGCCGCGCCGTCGGCGCCGTTCAGCAG CACGCGGGTAATGGCCGTGTAGCCCTTCGCGGCCTTTTCGGCGTCCTTTTCGAGTTCGGCGAGAACCCAAAAGCGGT GGCCGTGCAGTTGCGTGGTGGATTGGAGAATTCCAGTCAAGCCGATGGCCGCGCAGATGGTGGACAGTTGTTTCTTG CCGCGTGCGGCGGTTTCGGGATCGGTATGGTAGACGGGGATGTTCCACCACGTTTCGCGGCCCATGTTTTCACCGCT GACGGCCTTGACGACGAGTTCGAGCTTGCCACCGTTGCCGTTGTTCATGTTCTTCAACATGGATTCGGTGATTTCGA TTTCGACCGGACCCGCGATGAACGAACCGCGACCGCCGAAGACGCCGTAAGCTTGCGTGTCGAATCCACCGGGGAAT TGTTGAGTTTCCATGCTCATGATGTATTTCCTTGAAAGATTGAATGGTACTGCGGGAAGAAGTTTAGCCAGTTGTTT GGCCGTTGTCAAGCCATCGATTTGGCGAAAATTTGAGCCAGATTCGGCGGTTCGAGTTCGGCCAGCTTGCCAAAGCG ATCACGGGCGCGAATGCCGATGGTCGCTTTGTTCCGCAATGCGACTTGTTCGCCATGCTTCGGGATGAGAACGCGAT CCAGATAGGCGATGTTGTCGAACAGATGCGGAACCTTGACGTTCAAGTCCTTGCCCGGAAAATGCGGGGTCTTGGTT TGAACGCCCGCGTCGTCTTGCCAACCCATCTTGGCAATGAGACACAGATGTTTGTATTGCTGGTCGTTCAGCAGGTC AAGTTGCTTCATGGTGCGAACGGACATTTCGCCGTACGCTTGCATGCCGTGCTTGTGCTTCGGCAACTCGTCCTTCA AGTAAAGTTCGGCTAGATGCGTGACCGAATCCATGCAAAGCGTGTCGAACTGCGATGCTTCGGACGAATTGAACCAC CACAGGAAGAATTCGTCGGCTTGCGATGCGTTGTCGATCTTGTAGCCAGGGATGTTCGACGGGATGTTGCGAAGGGA ACCCGCGCCAGCTTCGATGAGCAGAAGCAACGGATTAGGGGCGGTCGCCATGAGCGGCGTTTTGCCCGATCCGGGCG GACCGTATACGACCATCTTCACGCCGAAGCGTTGCGCGAACTGGTTCGCCGGTCGTAGGTCGTTGATGTTCATGGGG CAATCTCCAATAACAGGCCCGTGTGGGCAAATACCGACACGGGCCAGCCAGTTTAACCCTTGGCGGGAACGAACTCA AGCGACGGCTTGCCGTCCGTGTACGACAGGACGCCATCGACCTTGGCTGCGAGCGGGGCGGGCAGCATCTTGTAGCC CGTCATGCTGAATTCGGGCTTGTACTTGATGGTCTGTTCGACCATGGCGAGCAGCGGTTCGCCCTTTTCTTCCAGCG CCTTGAACAGCGCTTCAGCCTTGATAGGATCGACCTTGTAGGAACGTTTGAAAACGGCTTTCAGCTTGCCATTGCTG AACTGATGGTTGACCGTGCCAGCGCCGGTTTCGGGGACGCGACCGGCGAAGAAGCGAGCGACGATTTCGTCGCGCAA TTCGCTTTCGGCCTTCTTGTAGTGCGCGAGTTCTTCGACGCTGTTCGTCCAGGCCGTAGCCAACGTGTCGTCGGACA TTTGCGAGAATTTCGGGTTACGTGCGAGTTCCATCTAAAACCTATTTGGGTTGTACTACGTTGAAAGAAACGACAGT TTAACGGGAAATCTTCACTTTGCCAAGCACAGCGTCTTCGGCATCGAGATTGCGGAACGCTGCGTCGTCGGCGTCGA ACTTGTTCGGGAAACGAACGCGCAGCTTTTCGATGTTCTTGCGCATCATTTCGGACATGGCCGTACCGTGTGCAGCG GATTCGGCGACGTACCACAGCACATCGCCCATTTCTTCGCCGACGTGTGCGCCGTCGATTTCGTCGGACAGGACCAG GGCATTCAGCAGGATTTCGGCGAGTTCACCGGCTTCGGTAATGACGCCGATGATGGCGTGGATTTGGCGCTTTTCGG CTTCGGTGAAGCCAAGGTCGCGGCCGTAGACCGAGTTTTCATGGGACAGGTCTTGCGCGTCGGTCTTCTGCGGCGTC TTGCCGTAGAACATGGCCTTCTTGATGGTATCGAGCTTGGCGGCGTACTTCGACACGCCTTCGAGGATTTCCACCAG ATTGCTGTAGGAAACCTTGCGGTCGAAGAAGTTCGGGGCGCTGGTACGCTGGGCGAGTTCGGTGTACTTATCAGCTT GCATCTGGACTACTCCAAAGGATGGTTGATCAGCCTTTCGGCCTAAGTCAAAAGTTGACAGGGATGATAATACAGGG CACAATCGGCCCCTGTCAAGTTGATATGCCCACAGGCGAAGGACGATATGCAATGTATACCGAAGACTATGTAAGCC CCATGATGCAAGACACGCGCAACATGATTCGCAACAGGCCGCCCGAGTGGACCTACGAGCGGATCGCCATAGAAACC GGCCTGTCCATCCATTGGATTCAATCGTTCATGGTCAGGATGCCGAACCCGAGCATCAACCGAGTTGAATACCTGTA TCACTTCATGCGCAAAGTCCATGGCTATAACAACTGAACAACTCAACTTCATCAACGCCGGTATCCCGGTCGAACTG AAAGGCTACCAACAATGGGTTGTATGGCGCTATGTGCAGCGTAACGGCGAATGGACTAAGGTTCCGTACCAGCCGAA CACGATGAACGCAGCTAAGGCGAACGACCCTTCTACCTGGGGCCTGTACGTCGATGCGATGAACACCGCGAACAATC CCGCAACCGATTGCGACGGCGTAGGCTTCATGCTTTCGCCCGATGATCCGTTCGTATTCATCGACCTGGACGACGTT AACAAGCGCGATAGCGACGGCGCACTCGTCTACGCCGAAGAGAACCGCGACGAAATGTTCGCAGTGCAGCGAAAGATCGTCGATGAGTTCGACAGCTATACCGAACTGTCGCCGTCAGGACGTGGCGTTCACGTCATCGTCAAGTGTGAAGACA AGAACGAAGTGTTCAAGCATGGCGGCGGGCGTCGTTTGGCCGTCGAAATGTACGCGTCGGCTCGCTTCATGACCATG ACCGGGAATGTCATCGAAGGGCGCAGCAACATTTGGGGCCGAAAGGAACTCGTATCCATTCTGTACCGTCAGGTGAA GATTCGCACAAATGGGTTTGAACCTTGCTTCACTCCGGGAAACGTGCAGTTTGTGGATGACGACGAAATCATTCGCC GTGGCTGCAACGCTAAGAACGGCGATAAGTTCGCAGCGCTCATTCGCGGTGACTGGCAATCACTGAACATTGGCGAC GGGTCGCAATCGGTGGCCGATCAGGCCCTGCTGAACATGCTGACGTTCTACAGCGGCAACCGCGAACAGATTAAGCG AATCTTCATGAATTCGCCGATGTACCGCCCGGGGAAAACCTCGACGAAAAACGGTCGAAGCTATATCGATTTCAGTA TCGACAAGGCGTTCGACATGACGCCGCCCGAAATCGATATCACCGCGCTAACCGAGCAATGGGACGCCTTGCGCCTG AACCAAGACGCCCCGCAACAATTGGAGCAAACAACCGAAATGACTCTGCAACCCGACAATAGCTTGATCGGCGCAAG CGTAGACGAAATGCCCGAAATGGCCGGGATCACAAAGCCCGCTGGCCTGATCGGCGAAATCGCCGACTATATCTACG CCAGCGCACCTCGCCCTGTGCCTGAAATCGCCCTGGCTGGCGCTATCGCCCTGGTCGCGGGGATTGCAGGCCGTGCC TACAACATCAGCGGCGCTGGGCTGAACCAGTACGTCGTGCTGCTGTCCGGCACAGGCACAGGCAAGGAAGCGGCCAA CAGCGGCATATCGCGCCTGATCAACGCCCTATCGGGCCGCGTAGAGGACGCAACGAAGTACCTCGGCCCCTCGAAGT TCAGCAGCGCCCCGGCCCTGTTGAAGCACCTGTCCGATCAATCGAACAGCTTCGTCAGCGTGTTCGGCGAGTTCGGT ATGTACCTGTCGCAAATGAGCGGCGATAAAGCGGCCGGATACATGGTCGAACTGCGCCGCGCATTCCTCGACCTGTT CACGAAGTCGGGACGCGGACAGACGATGCAATCGAGCGTCTACAGCGATTCGCAAAAGAACAGCAAAGCGATTATCT CGCCTGCGTTCTCGTTCCTGGGCGAAACGACGCCGGATCACTTCTACAACAGTCTGTCCGAAGAACTGATCAGCGAA GGCTTTCTACCGCGCCTGTGCATCATCCAGTACGACGGCATTCGCGTACCGATGAACTACGAACATGCGAGCGTAAA GATTCCGCAAGACCTGATTCAGCGGTTGGCCGCGCTGACGTTGCAGGCCCAAATGCTCAACGCCAAGCATACGCCAC ACGACGTACTCGAACACCCCGAAGCGAAGGTACTCGCGATGCGATTCGGCGAATACTGCGACGATCAAATCAACGGT GAGAACGCCGACGAAGTGACCAAACAGCTTTGGAACCGGGCGCACCTGAAAGCACTCAAGATGGCGGGCCTTGTCGC TGTGGGCATCAATCAGTACAACCCCGAAGTCACGCCCGAAATCATGCAATGGGGCATCGACATGGCTATGCGTGACT GCAACACGATCATTACGCGATTCAAGGAAGGGAACGTTGGCAACGGCGTTAGCGAATCGATTCAAGAACGGCGGATG ATCGAGACTTTCCGCTGGTGGCTCGAAACCCCAATCGAAGGATTGAGGAAACAAGGGGAAACGTACCGCAAGGCCCG CGAAGCCTACATCGTTCCGTACCGCGTGATTCAACAGCGATTGGCTTCGAAGGCCGCATACAAGAACGATAGACGCG GATCGGCAGCAGCGATCAGGGCAACACTGGAAAGCATGAAGAAATCCGGGATCATTCAACAAGTGAGTCCGAAACAA GCCGAAGAGGTAGGCGTATTGGGCGATGCATATATCGCACCAAGCCGAGAAAGATTGCTCGCATAAGGTTTCGCAGC GTTTACGGTGTTTACGGGGGCTGTTTACGGGCTAAGTGCTTGATTTATAAGGAAAAAGCGAGGTGTTTTCGGTGTTT ACTGTTTACGGGGTGGGGGTGGGGGTACTGACACCTGTCCCCTATTTAGATTTTCGATTTCGGTGTACCCCCGTAAA CACCGTAAACACCGTAAACGCTCTATGAGACAGACCGTAAACAGCACCGTAAACAGCCATAAACAGTAGATATATTT ATAGATAGATTTATAGATAGTTCTTTATATAGTTATATTTTTCTTTTTCGTATATGTAAAGGTTACAGAATGTATAT TTATTCGAAGCTGGTTCGAGAACTTTTAGATTTGAAGCATTTATACGATCATACGGTTAAGAATTCGCGCCTGTGGT GCATTCGCTCGCCTGTGGGCATCCTGCGACTGACCATCGAGAACGGCACGATCACCGATGCCAAGCCTGCCGTGGTG TCGGCGTGTACCCTGATGACCCAGGAACAGGCCAAATCGGCCGCACAGGCGCTTAACGATGCCGGGGCAGGGGGTTG CATAGCCCTACCCTGGGAAAAGGCCGTAGAGGACCATTACGCCGCCGTGCAAGAACGCCTAAAGGCCATCGAACATG AAGTGCGGTTCGGTGACGAGCGTTATTCGAGCGCTGTGCGGTACTATTGGGACTTGACACGCGAATTTCGTTCGGGA TATGATTGCTACAAGCATCCGGGAATGGCTCGGGTGCGTTACGTGAAGGGGCGTTCGAAATGAAACACACTCAATTT GGTGCTTTGCATGTTGGCGACGAGTTCATGATGGTCAACCCGGCCGCGTACCCGAATGCGGTCAGGTATCGCAAGTG CAGTTCGACCGAAGCGCAGCACGACGCAATGCGGCCCGAACATGTCGGGGCCTACGTGGTGGTGTGGCCGGTGAAGG TTGCGGACTCGCGTTTGGTCCAGTTCAGCGCGCTGGCTATCGGTGAGGAATTCTTTCGTGAAGTCGGCGGGGAACGT TACCAGAAGACCGATACCTATGCGGCGATGATCGTGAAGACGAAAGAGACAATCCAGTTCGGCGGTCGCATCAAGGT GATTCCGCTGATCGGTGGAATCGGGCGTGTGGACGACGATTCGGAGTGTGAAGCGCCCGCCGCTGTGGGCAACTCGA CCGAATACACGATCAACCTGTCCGAAAAGGGCTATCTCCGGTTGACCGAAACCGGGTCGTTGCCGGTGACGTACCTG GGCAAGACCATCGAAATCGGCCCGCTCGGGCGCGCCGAACTCACGGTCGGACTGATCGTCGATGCATGGCTCGAATG GGAGCAGCGCGAGATTTCCACCATCGAGGACAACGCCGCGAAGGAAGCCGAATCCATGGTGTTCAAATCGTTCGGCG AGCGCTACCTGTGGACGCAATCGCGCTACGACAAGATCGAAATGGAACGCCGAAACATTCGTCAAACGACGCGTGAA TCCATCTGGCAACTGCTGGGCAAATAGTGCTTGCACTCCGGTTCGGATCGTGTTGTAATACGTACATCGCAACACAA AACGAACCGGAGTAAAAGACATGTCCAAAGACGAAAAATTCTATCGCGAACGTAGTCGCTTGGGCTTCGCGGCCCTG GAACAACTCGAAGCTGCGGCCACGTTTACCGGCCTAACTGCGGATGAACTTCGCGACGAAATCAATCAGGTGGTGAA GAAGTACCGCGAAGATTTGATCGAACTGCGTCGCAAGATGCAGTCCGAAACCGATAACGCGGGTTTGCCGACCTATA GCGAAATCCTGGGCATGCTCAAGGAAGCACAGCGCCTGGGGCTGACTTTCGATATTGGCACCGCATACATCAGTCGC GCCTACATCGACAAACAGACCGAACTGAATGCCCGTATTAAGGCGGCAATACCCGACTGACAACCCTGCCCCGGTTC GCCGGGGGTCTTTCTAAAGAGGATGCATATGCAGCCCTATATCTGCGTGAACCAGTACGACGCGGGGTCTACGAATC TCGTCGTCATCAATGCCCGCTACATTCGGTCGATCCATCAGACGAACGTCAAGACGATGGACGAAGGAAAGAAGCTC GCGGGCGTCCAATCGTGCCTGCTGATGCAGTACGGCGACCTCGATATCAGCATCGTGTACGTGATCGAGCATATCTC GGTGCTGGCGAACATGCTCGACGCCGTAGGACGGCCGCAATGAAGCTGCTCAAGCTGATAGGAGTATCGAAGACCGG GGAGAAATGGCGATACGTCACGCTTCCCGTGTCAGAGTTCGTCGAAGCGGTCCAATGCATGGCGGGCGACTACAACGACACGCCGCCGAACGCCAACACGATGATTTGGCGCAGGGAATTCGACGATCCGATCTACGTAGTTGAAACCATCGGC GATATCGCCAAACAACTGGAAGGGATGCCCGAACTATGAACCGCTATAAGCAACTCGAACAGGCTACGCAACATCGC GAATCGGCCGAACGTGTCCGCGAAAAGTTGCGCGAGCATTACGGTAGCTCCGGCTATCCCGTCGAATGGGCGCGGCG AAAGATCAGCAAGGCTCGCCGCTTCGAGCGCAACATCGCGAAGTTGCAGGAAGGCAAGCCCTTGGGATACGTTGGCG CGTACGGTGCCGCTTTCAACCGCACGTTCAACCGGCGCGCTATGCCCGACCGCGTGAAGGCGAATTCGTCGGAACTG ACGGCCCGCCGTGTGCTGCGTGACCGCCGAATGCGCAACCGCGTACGCCAATCGTTCAGGGGCGACAAGTACGGCCT GTTCTACTCGCTGCACCGGCTGCTACGATTCGTCTAACACTCCGTTACACAAAAGCCCCGAAAGGGGCTTGTTTGTT TGGTCGAATAGAACTATGATTACTACATCGAATAAACAACCGAACGGAGCAACGAACATGAACATCATCAAAGACCT GCAAGCCCGCATCGCTGAACGCCTGACGGAAACGAAGAATCCCTGCAAGACGTACAAGACCGAAGAAGCCGCCGAAA AGGCCGCTGAACGTATGTCCGTCGATGTTGCGATGTACTTTCGCAAAGAACAATGGAAGACCGAAAAGGACATTCGT CCCGCACGCTACGTCGTGATCCACATCGCGGAAATGGACCGCTGGACCTATTGCATCGACCTGACAGAACTGATCAA CCGCGAATCGTCTACCGGCGGCTATCTCGGTTACTGCAAGGATATCTATACCTTCTGACATAAACCGCTTGACTGGT CGCACGGAGAACCCTATAATCTCCGTACATACTCTAGTTCATACAAGGAACTGTAATCATGATCGATTTCGAAGCCT ACAAGACCAAACACCCCGAATTCGTGTTCGAAGGCATATCGTACTGGTTCGGTACGCACGGCCGCTGGATGTTCAAG GTTGTCGATAACGACCTCAAGGAAAGCTGGCGCAACGTGCCGTCGAACTGGACTCGCATTCTGCGGGAATTGCCGAC GATGGAAGGCTTCGAGCGCGAACGCCTGCTGAACGAAGCCTCCGCGAAGGCGTTCGATGTGGTCGAACAAGTGACCG CGAAGAAGTCGAAGATCGAACAGCGCTTCATTCGTAACACGACGAAGGGTAGCGGTCGAATGGGTGGGACGCCTGAC GTTCGCCGGAATCGCCGCAAGTCCATTCGCATTGTGTATCGCGTCATGACCGACGCTCGCAAGCGGCATACGAAGCT GGGTGCGATGGCGAAGTGCTGGCCGTCGCACTGGCGCGAAGCCATCCGCGTCATCGAGCGCGCCATCAAGGGCGACC GCTTCGGCGACTGGCCGGATCGGAAATACGAGTTCTGACATGGAAAGCCACAACCAAACCGAACTGACCCTGCCGTG CGGTTCGGTTGTCACCCTGACCCTGCTGAACCAGCCGTTCAAAGGGTTCTCGTATCGTTGCGACGGCACAACGAAAG ACGGCATCCGAGTTGTCAAGCTCGGCGTTTCGCAAATCAACGCTATCGCCCGATGGAAAGAGGCCGTAAAATGGGAA CGCGTGAAGACGAAACGCTATCTGGAATCGTCTTCGCAAGCCCGCCGTGAACGCGGCAGACCTCAATACTTCAACGG TGAGAAAGTGCAATGAAGAACTACCCGAAGGTGACGATTCTGGTCACGGACACGAACGAACTCGAATGGCTGCAATC GGTGTTCATCGAAGCGGCACATCTGATCGAAAACCGCACGCAGGATTACATCTGCTACGCGATCAACATGTTCCAGC CGCGCATCCTGCATACGAAGGTTAAACGCATGACCGACAGCGAGCGCGAAGAGTACCGCACGCGCCGCAAGGCCGTA CTCCAAGCCCTGTGGATCGTCCGCGATGCCCTGTCGCCGAACATGTCCTTCATCGAATGGATGCGCAAAAACAACAC TGACGCGCCCGATGTGAAGGTTAACAGCCTGGGCATGACCACGATTACGTACGAAGGTGCGTTGCGTGCTAAACTGG AACTGTACCGGCCGCATCGTCTCGAATGGCTGGATCAAATCTTGTCCATCATCAACATGAAACTGTGAGAACGAAGC AATGCGACTCGACGCAAACGAAATGGTGAACTACGGTCGATTCAAGCAAGAATTGGCCCTGAACGCCGACATATATC TCGACGGCCAGCCTATCGTTGACGTGATTACCGCCGACACGAAGAAAGGCTACGTCATCCGTTACAACGGCCAGAAG TCGGACGACGAATTCGAGATCGAAACCATTCACGGCAACGTCATCATCGTTGACCGCAGGACCGGCCGTAGCTGGGG CAAATACTGGGGGACGAAGATTGACTAACATCAGCGCATACATCGGCCTGATCAGCATCGGACTGTTCATCGTATGG TTCGGCCTGGGCGTGTTCGCGGTCTTCTACGAAGATTGCGTCACACATGGCCCCGGCAAGTGGCATAGCTACATTCT CGCGCCTGTGGGCGTATTCGCTATGCTGCTGGGCTTCCTCATCATCTATCACGCGACAAGGGTGTTCATCCTATGAA AATGGACTTCGAAAACGTCTGGAAAAACACGCTCATTAAGTGCGTGAACGAGTACGAAGCGCTGCGCGAAACGCACA GGCAAATGTCCTTCTGCGGCCTGATCAACGGCTTCGTCATCCTGAACTCGCACAAGGCTGACTTCGACCGCTACGTC GAAATCGTCGGCATGTACGAAGAGACGAACAAGGTCGAATTCCGCGCATGGCCGTTCGAAAAGATCGGAAAGGCGCT GATCTTCGGGACGCGGGCAGGTGCTGACGCAATGCGCGCCGTGCTGACGCTCCAATACCCCGGGCGCGAGTTCGTCG TGTTCACGTATCGGAGCGTTCTTGAAAGCCGCATGAAAGGACTCGCGGATATCGTCGAACGCATGGCGAAAAGTGAC GCCGAATAGTGCTTGACAAGCTCAAAACGAAGCCCCTATAATGGGGCTTCTTTCATTGGAGAACGTCAAATGAAATA CGTTAAGAACATCGCATCGTACGCCGCATGGATCGCTGGCGGACTGATCGTAGGCGCTGTCATGGCGTCGGTCGTTT ACTTCTTCCTGGGGCAATCATGAAAATCCTGACGAACCGCGAATACCGCAAGGTCGTAGACTGCCGCATGAACGGCG ATATCGGTTGCCGCTTGCAACGTTTCGACGGCAAGGCCGTATGGGTCACGTTCAACGGCGGAATCCATGCCGTAGTC GTCATGCATAACGGCGACCGCGAGAACTACCACACCTGGGCCGATTTCCTGGACGCATACACTTTCCTCGACAACTG ACATGAACCCGTTCGAATTGATGTTCAAACCCGTGACCGCGATGAAAGATCGCGTTCCGGCCGAAGGTAAGCGCCCA CGGGCGAGCAACCATTACCCGTCCGGCAGGTCTGCGGGTCGCCCGTACGAATATCCCCGCGAAACGTATGTGAAGAT GGAAGCCATGCTTGCTACCGGACTTAGCGGCCGAAAGGTTGCAACGGCGCTGAATGTCAAGTACGATTCCGTCCGCA ATATGCAGCGTCGAATCTTTCGGGGCGATCCTGCATTTGATCCGAAAGGTAAATTCCCCGAACAACTCAACGAAGGA AACCGAGAAAATGGCTGACGTAACCGACATGGCTACGGATCACATCGAAATCGAAGACGAAAAGCGCATCGCGCACG TCCGCGAGCAACTGGCCCGCCAGCAGCGCGAATCCGCCATCGAAGGCGAGTGCGAAATGTGCGGTGAAGAACGTCCG CGTCTGGTCGAACGCCAAGGCCAATGGGCTTGCACGTTCTGCCGCGACCGCTTCAAGCTGGGGTAAACCGTGAAACG TACGCATCTGTGGTTCAACGAACGCGACAACGAATACCACGCAGCGCATAGCGGTTTCGCCCGCGACCAGGGCTTCG ACTGGAAGGACGTGACCAGGGACGGATACCATCAGCGCCGTGCGGTGTTTTTCGGCCAATGGGTAGGGTCAGCCCCT ACCCCGGACGAACTGCGCGCCAAAGGCACGGAACACGGCGAGCAAGCGGCCCTGTTCTGCTGGGCTGCTGCGTGCGC CAACGTGTACGAGTCCATGGCCTGCCTGAAATGGATGTTCGCAGTCCCAAATGGTGGCGCACGCGACCGCGTGACCG CATCCATGATGAAGGGCGAAGGCGTGAAGTCCGGTGTACCCGATATCATGCTGCCCGTGACGTGTCCCGAATACGCCGGTCTGTGGATCGAAATGAAGCGGGTCAAGAATGGTGTACTGTCTCCCGAACAGAAAGCGTACGCCGAATGGCTGAT CGGACAGCGCTATCAATGGGTCCGTGCAAACGGTTACATTGAAGCTCGTCAATCGGTGCTTGACTATCTTCGAATTA CGCTTTAATATTTGTTCAACGCTAACCAAACGGGGTAAACGAAATGAAGAAGCTCGTAATCGCTGCATCGCTTGCCT TGTTGGCTGGCGTTGCTCAAGCCGAAGTCATCGCCGAAGTGTCCGACGATTCCCGCAAGGTTCTTTTCTTCGAGGAT CGCATCGGATGTTCTGCTGGTCTGAAAACCGTCGGCGTGTGGAACTACGCACAAAAGCGCGTCACCATGACGGGCTG CTGGTACTACGAACCGATGAACAAGGGAACCGAAATCACGCTGCAATTCCATGGCGTTGACAAGGTTCAATATCTGC CCGTGTCGGTCTTGAAGATCGCCCCGGACTTTCACCATCGCGCACTCGCGCCGCAATAAGGAAAACACATGCTGGGA ACTTTCAAACGCTGGGCTAACGGTTTGGCCGCGATGCTCATCGAAATGGCGCATCGCGGCGAACTGCTCGACGCCAG CCAAGCTATGAGCAACTATCGCCCGCCGAAGGGCAAGGGCAAAGGCAAGGGCGCGACCGGCTTGCATATGGCCCGTG CGCGGGGTTACATCCGATGATCACATGCCCGACCTGCATAGCGGTTCGGGCGCGAATTCGAGCGGTCGCAATGTCTG CGGCCGGGCGATCACCTGAAAAGATCGCCGAAGCCCTGAACGCAATCTATCGTCAGGGCTTTTTCTTTGTTCGCTCG AATGTGCTAGTCTATCGCTCCAACATTAACGTCGAACATGTCATCAAGGAATTCAAGCCATGTGGAAATGGTTAATC GACAAACTGGTCCGTCTCGAAGCTCGTCTTGCCCGGTCCATCATCCATCGCGAATTGAAGCAAGCCGACACCGAAAC GGCCCTGCAATTCGCATATCGAGCGAAACGCTACCTGAACGATGAAATCCTCATCAACATGAAATGTCCGATGGTGG CGGTCGTGTACGTTCGCACAGGCATTCCGTGCCTGTGCCTGCACGACAAGACCTTCAACCGCGTGTACTTCGTAGAG GCATTCGTATGAACCGCTGGGATGAATTCGGACTACGACAAGCGAAGCTATGGGCCAGCATGTCGAAAGACCCGTCA ACCAAAGTCGGCGCGTACATCGCAGACGCGCTCAATCGCCCTGTGTCGGGCGGCTTCAATGGCTTTCCGCGTGGCGT AATGGACCTCGACAGCCGGTTGCAAGACCGCGCCGAAAAGTACCCCCGAACCGTTCACGCGGAACTGAACGCGCTGC TGAACGCGCCTGTGGGCGTACCCCCTGGCTCGACCATGTACGTCTACGGCCTGCCCTGCTGCGCGAACTGCGTAGCG GCCACTATCCAGCGGGGCGGGGTCACTCGCATCTTGCAAGCGTTCCCGAAGGATGACCCGCGAGCGCTCGAATGGGA CTTGCAACATGGACGAATTGCTCGGTCCATGGCGCAAGAAGCTGGAATCGAACTTATCAACCTGGGGTTCTAATGTC TACGCACGCCTTTAACGTACATCGCTCTACGGGTAGCGCGTCGGATCGTCCTGGCGTAGTTATAGCGACCGACGAAC ATGGCCGCAACGTCGGGGTCGTTGACCTGATCATGGTTCATCCCGACTATCGCAACGTTGTGACCGCATCCACGGTC ATGCGTGAAGCCATCCAATCGGCGATAAGCGATCTACTCGACGCCGAAATGATCCTCGACAGCATCAAGCCCAATCT GAAAGAACCGTCCGACCATCAATTGGTCGGCGGGATGATGTTCCGTATCGCCCACATCGCCCGAGTGTTGGAAAATG CCAACCTTGCCGCCGAACTGGGTATCGAAGAGTTACACATTCAGTTGCGTAAGGGCTTGCATAAAGGTTCGAACTAG CGCACAATAGACCCCGTTCACTTCTGAACACAACCTTTTCGGAGATACCTCATGTCCAAGCCCATTTCCAAGACGCT GCAATCCCTGATCGACACCATCGAAACGCAGGGTTTCGTTTACATGTCGGCCGGCGACCGTGCCAAGCTCGAAGCCC ACGGCTACGAGTTCGAAGTCAACCAAGCGATGGTCGATCCCGAAGACCCGGACTTCGTGGCGACCCGTTTCAAGACG TACGCCGAAGACGGCCAAACGGGCACTAATTCGGGTTCGGTTGACAAGCCGAACGAACAAGCGCAGAATTCGGTCAT CGCTTCCAACAACACCGAAGCGCAGCAGCAACCCCAAACCGCCACTCCGACCAAACCCAAGCAAGAAGGAAAGAAGC AAATGTTCAAGATCGCAACCGTCGCCATCGAAACCGTCGCCCCCGCCGCTCGCGCCAGCGCGAAGTACCCGTTCGAA CAACTCGAAGTCGGTCAATCGTTCTTCGTGCCGAACAGCGCCAGCGAAAAGAACGACGCCGCCAAGACCCTGGCTTC GACCATCAGCGGCGCCAACAAAAAGTTCTCGACCCCCGTCGAAGGCCAGACCAAAGTCATGCGCGGCAAGACCGTGC AGGTCCGTGAACCGCAACGCCTGTTCGAAGGTCGCCGTGTCGCCGACGGCGCGGCCTGGGGCGAAGAGTTCGCCGGT CAGGCTGGCGTGGCGGTCATCCGCACGCTGTAAGCAAAAGGCGCGACGGGCGCTTAATGGGGCGATCTACTCCAATC GCCGACCGCAAAGCCGCTCGTAACGCAGACCTTTTCACCCCCGCATGTTTTATTGCGGGGGTTTTTCTTTGTCCGGC GTTCCTGTAGACTCGGGCGAAATCAATCAACCGGCCAAACCTCATGTCAACACCGCCCGAAATTGCGATACTATCCG AACGCGTTTCGACCATGCAATCGACCGTCAACGACTTACGCGATACGGTCAATCGTATGGTAGAATCGCAAGCATCG ATGCAAGTTCTTTCGAATGACCTTTCGCATGTGTGGTCGGCGATTGATCGAGCCTTCATTGCAATCGAAAAACTGGC GAACGTTACGAACAGTAACGCCCGTGTCATTACGCAACATTCGACCAAATTGCGCATCGCTACGCTTATCATTGCGG GTAGCGCTGGTCTTGTCGGATGGGGCTGGAATACGATCGATGCTTTGCATCGCAATACGACCTCTTTAGACACCCGT GTCGCCTTTGTGGAGCGTGCGCAGCATGTCCAATCAGCACAGAAGTAAACTACGACGGTGTTTGACCGTCAAACGCG TTTTGATCGCGCTAGGTGGTGCAATTGCTATTGCGCTAGAAGCTGCGCCCGACGTTGCGTTGCATGTTTGGACGTGG CTTCCTGCGGATATCAAGGCAGAATTGCCCCCGCGATTTACGCCAGCCTTCGGGGTCTTGCTCGTCGTGCTGGCTAA CATCCGGGGAATTCTTGGCGCTTTTAAACGAAAAGGGAATCGAAATGTCAAGCAAATGGAAAAGTAAGATCGACGCC GTAATCGACCGCGAAGGCGGTTTCGTCGATCATCCCGCAGACAAGGGCGGGCCGACGAAATACGGTATCACGCAAAA GACCGCACGCGCCAATGGCTACCATGGCGAAATGCGCGAAATGCCGCGTGACGTGGCTTTCACCATATACGAACGCG AATACCTGACGCAACCGAAGATCGATCAAATCGCCGAACGCCTGCCCCTGGTCGGCGAAGCTGTGTTCGACTGGGGT GTCAATTCCTGGCACGCTACCCCGATCAAAGCGTTGCAACGCGCCCTGAACGTTCTCGTCCCGAACAACCCGGCAGG CAAGCCCGATGGCATCGTCGGCCCGGCCACCCTGCGCGCCTTGGACGCCTACAAGACCGCACGCGGGGCCGCTGGTG ACGCCGTACTCGCCGACATGATCAACGGACAGCGCCACGTATTCCTGATGGAAATCGCCGAACGCAACCCGTCGCAG CGGGCTTTCTCGTACGGCTGGGCGCGTCGTGTGACGGAGTTGCGCTAATGGACTACCTACAGCTTCTGAACGGCCCT GTGGGCATCCTGGGGGCTTTGCTGGCCGTCGTCATGTTCTACCTGACCGGGCGCAGGTCCGGCAAGGCCGACGCCGA ACGGGAACACCAGCGCCAGAAAGCCGAAGAGGCAACCGAAGAGGTTCGCAACATCAACCGCACAGTAGGGGAAAGCA ATGCACGCATTGAAGCTAATCGCCGCCTTGACGGTGTTGGCATTCGTGACCGCATGCGGAACGACTACCGTCGTTAA GCCGGTCGAATCCGTGTGCATTTGGGGTAAGGTCGTCACCCTGACCGACGACGAAATCGATGCACTGTCGATTGAATCACTCCGAACCATCCTTGATAACAACGATGGTTACATGGCGACATGCCTTAAGCGGTGATATACTGGGGCGTAATGA ACACGCCCCAGTAACCCAAATGTCCATCAAACAACTAGACCAATCGTTACGGGCCGCTTTCGCGGCCCATTTTGTAC GTACCGGCGACTATATGGAAGCCGGGGCCTTCACGTACCCGGACGACGGCGAATTAGCCATGATGGCCGCTGTCCAA TGGCAAATGGACGATTGGGTTAAAGCCGAGGTTGAACGCCTGAAAGCCGAAGGGCGCGACCTTCCGACGAAGGTCGA TCTACAGCGCAAGCTATGGACCCGAATGGATGCGTTGGCCGGTGACGATTTTCTAAAGGCCGCGAAGCTGTTCGCAG AAATAGCCGGATTCATCGAGAAACCCGCCGCCGTACAAGTCAATAACCAAACTAAAATCGTAGCGCCCCGAATGATC CATGCACCGAATTTCAGCATGGACGAATGGCAAGCTCAAGCCGCAAAGCAACAGAAGGATTCATTGGAACATGCTGA TTCCGTCAAAAAGTGAACAAGACGCGATTGAATCGGTACTTCAAAAGGCGCTGCGCTCGATGCCAGCGCCTGAAATC GTTTGGAAGCCCCTACCCGGTTCGCAGACCTTCGCGTTTACTTCGCCCGCTGCCCACACGCTGTACGAAGGCGCACG CGGCCCCGGAAAGACCGTCACGCAGCTTATGCGATTCCTTCGCCATGTCGGCAAAGGGTACGGCCAATTCTGGCGCG GCGTCATCTTCGATTTGGAGCATGACAACCTTTCCGGTATCGTCGCCGAATCTAAGAAGTGGTTCAATCTGTTCAAC GACGGCGCAAAGTTCCAAGAATCGACAGGCCTATACAAATGGGTATGGCCGACCGGCGAAGAATTGCTATTCCGCCA CGTAAAGAAAATCGAAGACTACGAAGGTTTCCACGGCCACGAATACCCGTTTATTGGATGGAACGAACTGACGAAAC ACCCGACTGGAGACTTGTACGAAAAGTTCATGTCGGTCAATCGATCTTCGTTCGATCCGATCACGCACACGCCCCGC GATGAAGACGGGAACTATCTGACATGGGACGGTAAACCGCTGCCCCCGATTCCGCTCGAAGTGTTCAGCACGACGAA CCCGAGCGGTCCCGGCCACAATTGGGTCAAAGACAAGTTCATCGATCCCGCACCGCGTGGAACGATTGTCCGCAATG TGGTTCGAATCTTCAACCCGCAGACCAAACAGGAAGAGGATTTCGAAACGACGCAGGTTGCTATCTTCGGATCGTAC AAGGAAAACCCGTTCCTGCCGCCCGACTATATCGCGCAACTATCCAAGATCACCGATGAAAACCTTCGTCGTGCTTG GCTGTACGGCGATTGGGAAGTGACCGCAGGCGGTGCGCTCGATGATCTATGGAAGGCTCGAATTCACGTCGTGGAGC GCTTCGTTGTACCTGAAAGCTGGTACATTGATCGCTCGTATGACGACGGTCGTTCGCATCCGTTCTCCGTCGGCTGG TGGGCCGAATCGGACGGAACCGAAGCCGTATTGCCTGACGGTACGCGCTTCTGTCCCCCGGCCGGATCGCTGATCCA AATCGCCGAATGGTACGGAACCGAAAAGATCGGCACGAACAAGGGTATTCAAATCGGCTCGAAGGCTATCGCACGCG GCATTAACGACCGCGAAATGGCGATGTACGTGAACGGTTGGATCAAGAAACAACCGCGCCGTGGCCCTGCCGATAAC CGCATCCGAAACGTGATTGACGATGACACCGAAACCCCCGCCAAGATCATGGAAAAAGAGGGTATCTACTGGAACCC TTCGGATAAGTCGGCAGGTTCGCGCACGGTCGGCCTTGAACTGATCCGCGAACGCCTATTGAACGCTATCAACAACG AAGGACCGGCGATATACTTCATGCGCAATTGCGTTGCGTCGATCAAGCTTTTGCCCGGCTTGCAACGCGATGCGAAA AACCCCGACGACGTTGACACGAAACAAGAAGATCACCCCTACGACATGGTTCGCTATCGCTGCCTTGTGGGCGCAGA TAAGGCCGTTTCGTCAATCAAAGTTCGACTTCCAACCTAAATAAAGGGCCGTTTATGCCTACGAAATCCCCGACGTT GACACCGCAACCGAACGCGCAATACATTCGCGAAGAATTGGTAGCGGTTCTCCCGACGTACCGAAAGATCGCCGATT GCCTGGGCGGATCGAAGGCCATCAAGGATAAGGGTACGCTGTACCTGCCGATGCCGAACCCGACCGACCACAGTCAC GAAAACAAGGCGCGCTATGAAGCGTATTTGCAGCGTGCCGTTTTCTATAACGTGGTGAAACGGACCATCCAAGGACT GACCGGGCAAGTCACATCGCGCCCGCCTGTCATCGAAGTCCCCGACGCGCTCGACCCCGTTGTCAAGGACGCCACGG GAACCGGACTCACGCTCGAACAGACAGCGAAACGCGCCCTGAACTACGGGCTTGCGTACGCTCGCGGCGGCATTGCC GTAGACTACCCGGACACTGGCGGAAATGTGTCCCAAGCTGAAATCGACAACGGCATCGCTCGCCCGGTTATCCAACT GTACGCACCGCAATTCGTCATCAACTGGCGTACCATGCCGCGTGGTGTCGAACAGGTCTTGTCCCTGGTCGTGATTG CCGAACCGTACCCGCTGGCCGACGACGGCTTCGAACTGACTTACGGTTGTCAGTTGCGAGTAATGCGACTCGTACCC GCAGGTCGTGACGCACGCACCGAAGGTAAAGCCGTACGTAACGGCGCAGCGTACCATTACGCGGTCGAAGTGTGGCG CGAACCGGCAGGCGCAGCGAAAGCATGGGACGGCGTGACCATCCCCGACAAGAAAGTCAAGTTCGAAATGTCCGAAA CGTACTACCCGACGTTGCCGAACGGTGAACTGTTCGACGAAATCCCGTTCCTGTTCTTCGGCGCAGAGAACAACGAC GTGAACGTTGACGTTCCCGCAATGGCCGACCTTGCCGAACTGAACATCGCGCACTATCGCAACAGCGCTGACTACGA AGAGTCGTCCTATGTCATGGGTCAACCGACTTGCGTAGTTACCGGGCTGACGGAAGCGTGGTACAAGAACGTCCTGA AAGAAACGATCCCGCTCGGTTCGTATGGCGGCGTACCGCTGGGCGAACATATGGACCTAAAGTTCGTCGCAGCAGAA CCAAACACGTTGCCCGCCGAAGCCATGAAGCACAAAGAGGCGCAAATGGTCGCACTCGGCGCGCGACTCGTCGAACA ACGTACCGTGCAACGTACCGCCGCCGAAGCCAACAGCGAAACGGCCCGCGACTCGTCGATTCTCGCATCGACTGCGA ACAACGTTTCGGACGCCATCGAATGGGCTTTGCGCTGGTGCGCTCGCTTCCAAAACGTAGAGGTTCCCGAAAGCGGC GACGGTTCCATCAAGTTCCGTCTGAACAACGACTTCCAGATGATGACGTTGACGGCCGAAGAACGGAAGATGCTCAT CGCCGAATATCAAGCCGGTGGCCTGTCCTGGGGCGAATGGCGTGGTATCCTGCGTCAAGGTGGCATCGCGAAGGACG ACGACAAGGACGCCGAAGCCGCCATCAAGGAAGCGCAAGACGACGAACTCGACCGCGCTGTCAAGACGGCAGAAGCC ATGGCCAAAACCAGCGGCGAACCCAAGGACAACAACCAATGAAAAACGTAGGCAATCGTTTATTCGATGCCTTGACC CGGCAACAAATCTATGTTGCCGGTGTCGCCCTGCAATTCGCATCGGAAAGCATCGCAACCGTAGACGAAGTAATCTA CGAAGCCGAGCGAATCGTCGGGCGCTTCGAATCGGACACGCTGAACGAAAGTTCGCAAAAAGCCTTTCTCGTTTTGC TGGGGTCGATCATCAAGTTTTTGCGGACTCGCTTTGACGCCCACACGGCGAAGCGCATGAAGCAACTCGAAGAATTG ACCGCCATCGAAAGGCGAATGAATGCTCGCATTATGGTTACGGTCGAAACCGAAAGCGAGACTCCCGTAAGCGAAGC GAAGGCCGACGCCTGGATCAAGGACAAGGGCCGCGCTCCGTCGGGCGGTATTCTGCTGGCCCTGTCGGCTTCGCGCC TGTGGGCGTCCATGTCGAACGAACCGATGGGTCCGGGCCTGCTGCTGTCCGGCATGGTATCGAGCCTCGGGGATCGT GCCGAAAAGCGCGCCGCAGAAATTATCCGTCAAGCTCGCGCAAACGGATGGACTCGCGAAGAAACCATCGCCGAACT GGAACGCCTGCGCGGTCAACTGCGCGTCGAAGCCATGAGCGCAGCAATGACGCAAGCGAGCGCAGTGTCGCAACGCGTGCAGGGAGTGTTGCAGGCCACGGGCGGAACGGATCGCTATATGTGGATTTCCGTACTGGACTCGCGAACAACGGAT ATCTGCCGTTCGCGAAGCCGTCGCATCTACGTGTACGGTCGTGGACCTGTGCCGCCAGCGCACTACCGTTGTCGTTC CCATATCGTGCCGTACTACGATGGCATGACGCCGCCCGAAACGTTCGCTGAATGGGTTAATCAGCAATCGCCGGAGT TCATCAATTCGGTGTATACTCCCGCCACCGCTAAGGCAATCTTGAACGGAACCGTCGAACGTTCAACGATTGAGCGC TTCCAGGTGGAGAAACCTCTAAGCCTGGATCGCTACGCAAAACTGATCGACGACATTATGGGCGTTCGCTGAACGCT TCTTTAAAGGTGATACCGATTATGGCCCTGAAACTGAAACTCACGAAAGACGAATTCGGCAAGCTGCCGAAGGAAAT TCAAGACGAATACATCGCCGACGGCGACGGCTACAAGCTCGACGTGTCCGACCTCGAAGACACCGGTCCGTTGCGCC GCGCCCTGGATCGCGCCAAGGCCGACAAGTCGGAAATGCAAGCCCTGATCGATGAGCTTCGCGAAAAGCAAGACAAC ATCGACCGGGACGCCGCCCGCAAGAACAAGGATATCGACGCGCTCGAAAAGCAATGGAAGCGCGATCAAGAAGCCGC CGTCGGCGCGGTCAGCGAAAAGCTGTCGAAAGCGCACGAATTCATCGAGCGTCAATTGGGCCATTCGGTCGCCGAGT CGCTGGCGAAGGAACTCACCGATGCGCACGCCCTGATGCTGCCGCATATCAAGTCCCGCATCAAGGTGAACACCGAG AACGGCGACTTCCGTACCGTGGTGCTGGACGCCGAAGGAAAAGAAACCGCGCTGACGGTCGCCGACCTTGCCAAAGA ATTCCGCGCAGACAAGAATTTTTCTGCTATCATGCGGGCATCGAAGGCAACCGGCGCTGCCGCACCTTCGAAGCCCA GCACCAGCAGCGCCGATGGCGGGAACGGTGGCCCCGAGCGTCAACCGCAAACCCCTTCCGGTAGCCTTTCCATGGAC TACCGCGCTTTGGCCCAAAACATGGCGGCTAAGATGAAGGAAGAAGGCGGGGACGAGTAACCGCAAGGGGGTCGAAA GACCCCCGAATCATTTCAACAACCACAGAGGAACAACATATGTCCTTGAATACCTTGAAAGTCTACAGCCGGTCGCT GTATACGGCGTTCGTCGAACGTCAAGACCAATTCTTGAACGTCTTCAACGGCGCATCGCAAGGCGCTATCGAGCTGA CAGCCGCCGCCGTGCAGGGCGATTTCGAATCGTACGCGCACTATGGCGTCATCAACGACATGGTTCGCCGCCGCAAC CCGTACGGCGATGGCGCGATTCCGCAAAAAGAAATCTCGATGAAGGAAGATACCATCGTCAAGGTCGCCGCAGGCAC GCCCGAAATGCGCATCGACCCGGGCCAGTGGCGCTGGATTCAACGCTCGCCCGAAGAAGCCGGCGCGTTCATCGGTA TTCAACTGGCCGACCAGTCCATCAAGGACATGCTGAACACGTCGCTGGGCTGCTACGTCGCCGCCACCGCCGCGCAA ACCGAAGTGCATCGCGACGTGTCTGGCGCGACCGACCCGAAGGAAGCGCAATGTTCGTTCGTCAATCTCGCCAAGAC GGCGGGCATGTTCGGCGACCGTTCCAACGCCATCCGCGTTTGGGTCATGCACTCGACGCCGCGCACGAACATGTTGG TGAACAACCTGAACAACGCCGAACAACTGTTCGTGTTCGACACGGTGAACGTGTACCGTGACGCCGAAGGCCGCACC TTCATCATTACCGATTCGCCGTCGCTGATGGGCGCCGACAACAAGTTCTTCATCGCGGGCCTTCGCCCCGGTGCGAT CCACGTCAGCCGCAACAACGACTGGGACAGCACCGAAGTGGACGCCACCGGCAGCGAGAACATCAAACGCACGTTCC AGGCCGAATGGTCCTACAATATCGGGCTGAACGGCTACGCCTGGGACAAGGCCACGGGCGGCAAGGCTCCGACCGAC GCCGCGCTGTTCAGCGCCGCCAACTGGGACCGCTACACCGAGTCGCACAAAGACCTGGGCGGCGTCCTGCTGACGAC CAAAGAACCCGCGTAATCATCGAACCCGGCCAGGGGTAAGGCTTCGGCCTTACCCCGCAAGGAACCCGCATGAAACA TCCGAAAATCATCTTCTTCACGCGTGACGCCGTGCCGAACAAGAAGGAAACCGCCGCGATCAAGGCTATCCCCTTCC CGGTGTCCGTCCGCAATGCCCGACACATCGGCCCGAAAGATGCCTGCGAACCGTGCGCGGGCGTCCTGGGTCACATC CCGGACCAGTACGACGACTTTCCCGACGGTGCGGCCGTAGTCGCGGCGTACGTCGAAAAGGCCGCGCAGCGCGAAGC CGCGTTGCAATCCCTGGACGTTCCGGCGCAACAGCCACCGGCCAACACCGAAAAGCCGCCCGCGAACGGGACCGACA AACCGCCGCTGGAACCCGGCGCGAAACCGGCCGGATGGGTCAGCGGAAACTAAGGCTCAACACGCCAAACCAAAATG CCCCGCTGTGGGCATTTTTCATATCGAGGGACACTGTATGCACGTATACGACAACGCATTGAAGATCATGTACTTCA CCAAAGGCCCGACGCCGACCGCCGCTGAAACTGGAGACTAAACCATGGCTACTATCATTGTCGAAAATGGTAGCGGC GTCCCGAATGCGAATAGCTACGTGGACGCCGCCGAAATAACCGCGTTCCTCGAACTGATGGGGGTTGATGCGGGCGA AATGACGCCCGAACAACTCGCGATCACGTCCGCCATGTTCATTGCGGTGTCGGTCAAATGCTGGCCTGGTTGCCGCA CCACTGACGTTCAAGGTATGGACTGGCCGCGCAAAGGGGTATGGCTTTCGTGCAGCGACCGCCCCTACCCGTCCAAC AAGATACCGGATCAGTTGAAGCGGGCGCAATTGTTCGCCGCGCTCGCTGCTGCGCAAGGTATCGCGTTGTTCCCCGC GTACGATCCGACCGCAGGCAACATCAAGCGCGAAGAACTCGGGCCGCTGAAAACCGAATTCTTCGGTCAAAACATGG ACGTGTACGGCATGTTGCCCACACTTCCGGCCGTGCAAGGCTTGCTTGACGAACTTACGTCCCGTGGTTGCGGTGGC GGTCATTTCCGCGTGGTGCGTGTATGAGGAATCCTACCTTTACCCGCTTGCACGCAACGGCGCAACGACTCATCGCG AAGAATGGCGCAATTGGCCAAATTCTGCGTGAAGAGGTTCCGCCGCATAAGCCCGGCGAAATGCCGCCAGATCCGGT CGAACGTGTCGTTCACGACGGGCCGATTTGCGTTCTACCGAACAACAGCGAATTGCGAAAAGCTTTCGACGCACTCG CCGGGAATCCGACCGTTCAAATCGGTGAACTCGTCGGGTACGTTTCGCCGAAGGACGGTTCGATTGAATTCACCATT ACTGACGTAATGGTATTCGCCGGACACCGCTATTCCGTCAAAAACGGGATCAACTACAACCCCGACGGACAAGGGAA TATCCTGCATATTCTCGAACTCCAAAAGCTGAACTAGGTTCGATATGCTGACCACACGCAAAGAAAATTGGGTCGAA ATGTTCGACCTGATCAACCGAACGAACGACGGTCTGAACGCACAAGACCGCATACCCCGCATCTACTTTCCCGGAAC GGTCGCGAACAACCAAGATAGTTCTACGGGGGCCTGGGCGCGTGTTAGTATCGACACGCTCGACGACCGCCAGGATA CGTTAAGCGTCCCGGACGGCCCAGGCGGAACGAAGCGCTATCGTACGGTTGGACTGCTGTTCATACAGCTTTTCATC CCCGCCAGCGATTCGCGCCGTGTGGGCATGTTGCCGTTCGTCGCTGACGCGTTCAAAACCGCGTTTCGAAAGTACCC GCATCGGAACGGGCTTGTTTTCCGCAATGCTCGCTATGATGCTTCCATCCCCGCCGAAAAATCATTCGAAAGGGCCA ACGTCGTTGTCGAATTCGAATACAACGAAATTCAATAAAGGACCGATATATGGCTTACAACTGCCCCGTATCTAAGC AAAACTCGAACGATTCGAGCTTGCACGTTGCCGAAGAGGATTGCCTGAAACAACTCCCCGGCGATCCCAATGGGCCG AACCCTGGCGGTACGCCGGTCTGGTACGAAATGGAACCGAACGAGTATTCGGATTTCGGCCAGGAAGTGACGACCGC CGCCCGCGCACCGCTGAAAGCGAACCGCTCGAACCTCAAGGGTTCGCCGACCGATATCGACGCGTCGGGCGGCTGGAACATGGACGTGACGAAGACGAACATGTCGCGCCTGATGCAAGGCTTCATGTTCGCGAACATGCGCGAACTGCCGAAC AATACGCCGATGAACGAATCGTTCCGCGCCAACTTCGCCGTCGGCCTGAACAAAGTCACCTATGACGCTTTCCCGGC CGGTTCCGATCCTTCCAAGATCATGCAACAGCCCGGCTCGATCTTCGTCATGTCCGGCAACAGCAACCCCATCAACA ACGGCGTATTCATCGTCGAAAGCGCCGACATGGCGACCCGTACGATGAATCTCGCGGCCAGTACGCCGACCGTGGCC GAACCGCCCAATACTATCGCGACCATTCGCACGGTCGGCCTGTCGAACGTCGGCTTCGACAAGTCGTTCGAACTGAC GGTCGTCGGTGGTCAACTGCACATGGACGCATCCAACCAAGAATCGCTGCCCGGTTCGCTGTGGTGGCTCGGTGTGC GCGCCGGAACCTGGGTCTACCTGGGCGGCGATCAAGCCGTTCATCGCATGGGCGGTAACGTCGGCTATGCCCGCGTT GCGCTCGACTGGAACCCGAACGAGAACCCCGACGACCTCGAACGCGTACGCTTCGACCTGACGACGTTCACGCCCGA AAACCATACGGTCGCTGAAACCGATCCGGTGCAAATCTATCTGGCATCGTCCATCGCCAACGGTCGCACCGCCGATG AAATCCGTCGTCGTTCCTACACGATCCGGCGCGGCCTGGGCTACGACGCCGACGGCGAACAGGCCGAATACCTGATC GGTGCCGTACCGAACGAGTTCACGCTGAACGTGAGTGGTCAATCGCTGCTGAACGCCGACCTGACGTTCGTCGCGGT CGAATACGACACCAAGGACGGCGCGAACTCCGAAATGCCCGGTATCATCATCCCGGCGCGTTCCGAAGCGGCCTACA ACACGTCGTCGAACGTCTTCGCCGTCAAGCTGTACGTGTACGACAAAACGACCTCGAAGCCGTCGGCCCTGTTCGGC TACCTCGAAGAAGGGACGATCACCATCAACAACGGCGTCACTCCCGACAAGGCCGTCGGCGTCATGGGCGCGTTCGA TACGTCGCAGGGCAACTTCACTGTCGGCGGCGAACTGACCGCGTACTTCACGACGGTTGCCGCCGCTGCGGCCATCC GCAACAACGCCGATGTTGGCCTGTACAACATCTTCGCAGCGGACAACGCGGGCTTCGTCGCAGATATCCCGCTGCTG ACGCTGGGCGGTGGCCGAATCAACGTCGTGAAGGACGAAGCGATCAAGATTCCGCTGACCATCAACGGCGCGCAAGC GGCGTCCCTCGAAACGCTGTCGTTCAGCTACTTCGCATACCTGCCCGATAGCGCCATGCCGAAGTAAACGAAGCATT GCCCCGCCTGTGGGCATGCCGTAGTATCCGGGGTGTTCAATTCGAACACCCCTTTCTTTTGGAGCAATACATGTCCC TGACTTCGCATTTCAAGATGAACGAAACCGCCATTACCAAGGGTGTCCCCGTTCAACTGCCCGCCAACTCCGACGGC TCGATCCCGACCATCTACGTCGCCCGCATGCACGGATCGAACACGCGCTACCAGAAGGCCGTGACCGCCGCCATGAA GCCCTACACGTTCGAAATCCAGCACGACAAGCTTTCGAACGAAGTCGCCGAAAAGCTCATGCGTGACGTGTTCTCGC GTACGGTCGTCACCGGCTGGGCGAATATCCTCAAGTCGGACGTGTCCGGCGATCCGAAGGCCGAAGGGTTCGAGCCG TTCAGCCCCGCCGCCGCCGTGAAGCTGTTCGAAGCGCTGCCCGAACTGTACGAACTGCTGGTCAAGAAGGCGCAAGA CGCATCGGCGTTCCTGGCCGCTGCCGACGAAGCGCTCGCGGGAAACTAATCGAGGTTGTCGAATGGTCGGTTAAGAA TGGCGGCAAGCTCGACCTTCTTATAGCGACCGTTCGCAACACTAACGATCCGATCCCCGACGTACTCAAGAATCAAC CCAAGCTTAAACCCGGCGCGCAATTTTATTTGAACGCCTTTCACGATTTAGACCGTGAACGACCTGTCGGGTTTTCG CTAGGCCCCATCGGTTACTTCGCCCTTCGCAGCTATGCGGCGTTGTTCGAACTAGACGAAGATGAAACGCAAACCTT CATCTATGTTCTATGCAAAATGGATGATGCATATTTGAAACTCAAACGGGCCAACACCAAATGAAAACTCTGCTCGA CCTTGCTAAAGCGATGGAAAAGCTACAGAAAGAAGTTTCGACGGCCGCTAATG

[0098] SEQ ID NO: 20 (exemplary genomic sequence for phiACH07) TGCGGGCGCACGCCGCGGCCTTCGGCAAGGACAGCGCCATCGCCATCCTCAAAGCCGGCGGCTCGCCGACCGGCGCC GCCAAAGACCTGCCGGAACTGCGCCGCAAGTCCGTCATCGACAAACTGATGCAGGGCGCGTAAGCACTCTCCACCCA ACCTGAGGGCTTCGGCCCTCTTTTTGTTAAGACAAATCATGGAAAAGACGATCGCCAACTGGTTCCGCGCCTCCACG CCGCAACCGCAGCCCCAAAACCTGTCGACCCAGCTCGGTTGTCACTTCGAGGAAGTGGCAGAGATGCTGGATACTTT GAACGGGCATTCCGAGTACGCGCAGTACGTTTTGAGCAATGCTCTCAACGCGCTGGAAGTGCTCAGCAACTACTGCA AGGAAAACGCGGGCATGATTACGCTGGAAGAAGGCATGCGTGCGGAATTCCTCGACGCCATCTGCGACCAAGTCGTC ACCGGCATGGGCTGCGCAGTACTGCACAACATGGACCCGCACTTCGCGCTGATCGAGGTCAACCGCTCGAACTGGTC GAAGTTCGTCAACGGCCAGCCTGTGCGTGACCCCAACACCCAGAAAATCATGAAGGGCCCCGACTACTTCAAGCCGG ATTTGTCCAAGTTCGTCTAACGAACGCAGGTTTTCCTAGAGCCAGATTAGAGTAATATCTAATCTGGCTTTTTCAAT TTACCTAGGAGCAAGAGATGCATAAAAATAGCAAGGAAGGCAAGGACATTCGTACAGTGCGGGTCTTGGAACACTTG TGCACCACCAACGCTGTGCGTAGGGGTGCTGTATGGACTGACTGCGAAGAGCAGGACATGAAGCGAGCCTGGATGCA CGGGCTGAGCATCGGCTCCATCGGGCTGATCCACGGGCGAACTGTCGGTGCCATCCTGTCGCGACTGCGTCAGTGCA AGTTCGTGGACGAGGACATTTACATGGCTTTTGGCATCTTCGCAGACTTCACAGTGCTGAATTGCGGGTCGGAATCT ATCATCACTGAAGGCATGAAGAGCGGTATACTCTGCCGCTCGAACCGCAGCCAAGCGCTGGTCAAAGTGGAAGACAA GCACCGTTGGCCTCAAGCCGAATGCTACATGAACTATGTGCCGGCAACCACCGTCATCATGGGCACCACTCTGAAAC GCACGCCTCTGGTGTTCTACTACCCGCAAGCTCTGGCGAAGTCGGCCTTGCAGACGTACATGCGCCTCAACACGGTG GCCACGCACAACCGCATGCCTACGTGGGACCTGAAGGACATGTGCCGCAACCACTTCCACAAACCTGACGAAGCCCT CCATCATGCGATGGGCGTTGCAGACCGTCTTGACGAGCGCTCGCATAACCTGCCGAATGCCACTCATGCTGGGCGTG GAGGTGGAAAGAGCGTGCTGATGGTACCTGGTGTTGGTGTGCGCATTCGCGACGAAGAAGGCACCGTGGTACAAATC GGCAGTCTTGCCGATTGGCACGAGCTGACACCCGAAGTCATCGCGAGCCCCGCCTTCAAGCAAGCTCTGCAAAACGC AGGTTTTCAGCTTCAAGCCCTCGATGTAAAATCTTCTCAATGCGTGAATGAACACGCAGCCAACCAGGAGCAAGAAA TGAAAGAAAAGATCCAATCCGCCATCAACCTGCTGGAAACCGGCGTCAAGTACCCGAAGGTCCGGTTCATCGGCACG GAAGACAGCGGTCGTGAGTACACGTACAAGCACCGCGGTGACGTCAAGGTCGGCGACTTCGCGGTCGTGGTCGTGCC GAGCGGCCAAGTCAAGCTGGTCCAGGTCGTTGACTTCGACGACGCGGCCAACCTGCAGCCGAACGTCCGTTACAAGTGGCTGGTCCAGGTCATCAACATGGACAACTACGAAGAGCTGGTGGCGCGTGAAGACGCGGCCCGCGAGAACCTGCGC ATGACCATCGCCGATCGTACCCGCAAGGAACAGCTGAACAACTTGCTGGGCGAGCTGGGTGAATCGCCGCGCGTCAA CGCGGCCATGGAACTGCTGTCGCCGACGTCGATCGACAAGGCCCTGGACAACTCGCTGGACTACGCGTTCAAAACGG CCGAAGCGCGCCTGAAGGCCGTGGCCGAAGCGGACCCGTCGAAGGCCGAGCAAATCGGCAAGGTCCTGGACATGGCC AAGACCCTGCGTGAACTCACGAAGCCGGCTGGTGGTGTCGCCGGCGTTCCGGGCATGGTGAACTGACATGGCGACCA AGTACGTTGAAGTCGTCTTCGCGTCCAGCTCCAAGCGGTACACGTACCACACCGAGCTCGATCTGCAGGTCAACGAC CATGCCACGGTGCTGACGGCCGACGGGGTTACTCCTGTCACGGTGGTTGCCATCCTGAAGCAGGCGCCGGCCTTCAA GACCAAACCGATCCACGCGCTCCGGGGCCGCCCGGGCAGCATCTAAGCAAGTGCCCGGCTCCGGCCGGGCGCAATAC TTTGGAGCCTTCATGGCACACGCCAAATTCTCCGCTTCCGGTAGCAGCCGGTGGCTCAACTGTCCGGGCTCGATCCG CATGGCCGAGATGAGCCCAAAACAACAATCCTCGGTATTCGCGATGCAGGGTACTGCAGCCCACGACCTCGCCGAGA AGTGTTTGATGGGCAATCTGCGCACGGCTGCGTCCTACAAGGGCGCGTATGCCATGGTGCAAGCCAATGGTGCGGTC TCCCACTTCCGGCCCAACGCCGATGTGAAGCCCGATGCCCCCAACGTGTTCCTGATCGATGATGATATGATCGAGGC GGTAGACGTCTATCTGGAACTGATCCACGAACTGCGCACGGAGCATCCTGATGCGGAAGAGTTTATCGAAGCCCGCC TGGACCTTTCCTTCATACGCCCGAACATGTTCGGCACCGGCGATTATCTCCTCGCTGACTGGACCGAACGGGTCCTC TACATCGTTGACTACAAGCACGGCCAAGGCGTACCTGTCGAGGTGGAAAACAACTCACAGCTCAAATACTACGGAGT TGGCGGAGCTCACCGGGTGGGCGGGTATGACGGGTATGATAGGATTGTCCTCATTGTCGTACAACCACGATGCCCAC ACGAAGACGGTCCTGTTCGCCGATGGGAAACCACGCCTGCTGCTCTGCGAATGTTTGAGCAGGAATTGGCACAGGGC GTTGACCGAGCTAGTGAAGACGACGCCATGCTATCAGCTGGCAAGCATTGCAAGTTCTGCCCTGGAGCAGGTACTAC CTGCCCCGAGTTTGATCGCGCCGTGCAACGCGAGGCAGGTGCTGATTTCGCATTGGCACCAATTGATTTCGTCGCTG ATCCTTCGGGAGACGGCCAAGTGGAGGTCCAGAAGGAGCTTCCCATGCCGCTCACGCCCAAGCAATTCTCCCGCGCG CTAGAATGGGTCCCGATTATCGACACTTGGGTCAAGCGCGTCAAGGCCCATGCTGAACATCTGATGCTCACTGGCGA GATGCAGATTCCTGGTCAGAAGATCGTGGCCAAGAAGACGAACCGCAAGTGGTCGGACTTCATGACGGAAGAAGAGC TGATCGAAGAAATCCTCAAGGGCGACCCGGAAGTCAAGCGCGAGGACTTGTTCGAACCACCTAAAATGAAGGGCCCG GCTAAGGTCGAGAAGCTTTCGAAAGCGATGAAGGCGCATATCAACCGCGTTCCGACTGTCGAAGAGCTGCAAGACCC GGATACGGCCCCGAAGCAGCTGGTTTATAAGCCGGAAGGTGCGCCGACGATCGCCGCTTCTTCCGACCCTCGCGCTG AGCTTACGCTCTCGCTGGACAAAGGTGCCTCGGACTTTGCCGAGATTGAAGTGGACTTTGACAAGGAATAGCCATGT TCTACTGGATTCGTACCAAGCTGGCCCTGGGCCTCATGCACTTCATCAAGATCGCAGTCGACTTGACGTGCGTCGTG GGATTCTTCTGCGAGGCCGTGCTGGCCTACAAGGTTCTGGAGTTCATCTATGGTACGGCTCCAGAGTACATGCGATA CATTCAGCTCTTTGCCCTTGCTTGGTTTGTCTACCGCGTTATTTACTGGTGGATCATCTCGCAGGGGCAAGGAATCA GACCGGCACTCTTGGCTGCGATACGGGGCCATGTGTTCAAGCTGTTCCGCCTCATCTAACCACCCGCCCGGCTTAAA GCTGGGCGTTTTTATGCCCGGTTGAGTATAATTAAATCTGGACAACCAACTCGGAGCAGAGTTATGAAAGCATACAT CCCCGTAGTATACATTCGTCGCGACAAGCCCGTAAAGTTCCCCGTCATCCTGGCGCACAACATCAAGGGCGCAGTCG ACGAGTTCTTGCGCCAACAACAGCGCTACAGCCTCGCGATTCCGCTGAAAGGTCGTGAATTCTATGCCACGGTTACC GGCGAAGATTCGCGTGTATGGACCCGCCGTATCGTCATCATGGATGTCGGGCTGGAAAGGAAATGAACACGCGCTGG CGCAGTGAAAAGTTTTCTCACAGCTGGACTGACGAGCAACGGCAGCTCCAGCAGTGGGAAGACCAAGCCACAGCGAA CGAAGTCGCGTGGTATCGCCAAAAGGCCTTTGAGGCCTTTTTCCCCACTCAACAGCTTTCCCTCAACCTGGAGTTCA ACAATGACCCTGTCCCGCAACGACGAGCGCCGTGTACGGAATCTGAAGCAAGCCCTGCGCTACGCGCAGGCGGAACT TCCGAACCGCCGCGAGTCGGCATACCACTTTACCATCCGCCAAGCAGTCCGCGAGATGATTCATCAGCGCTTGGTTG CGCAATCGGCGGCCCTGTTGGCTGCTTCTGCCACGTCTGCATGAAGTGGTAAACTGTAGGCGTACAGCCTGAAAACT GTACGTCTATAATCTCTTCACTGCATCACATTTTGTGCTGCAGCAATCAGTATGAAATTTATGAGGATTACTTATTA TGGCAATGGTCAAGTGCGTTACCCCGGTTGGTCGCGTATCGTTCCCCTCGGTCTTCGCCGCTTCGTCGTATGAAGGT TCCGCCCCGAAGTACAGCTTGATGCTGGTCTTCGAGCCGGAGAAGTTCACGCCGGGCCAGCAAAAGCTGTGGGATCA GATGGTCAAGCTGGGCGACGACGTCTCGCTGGCGAAATTCAAGAAGAAGCTGGACGCTCTGCCCGGCAACTTCAAGA AGCCGATCCGCGATGGCGCCGAGAAGGAAAACCTGGCCGGTTTCGGCGAGGGCAAGAAGTTCATCACCTTCTCGTCG AAGCACCGACCGGGCATCGTCGATGCCAATGGCAACCCGATCGAACCGATCATCGACCAGGAAACCGGTCGTATCGA TCTGCAGGCGTGCAATGAAGAGCTCTTCTACGCCGGCTGCTACGCTCGTGTGACCATGACCGCCTACGCCTACGACA ACGTCGGCAAGGGTGTGGCCTTCGGTCTGCAGAACATCCAGTTGATCGCCAAGGGCGAACGCCTGGACAACAAGGTC GATGCGGCCAGCGACTTCGCCGGTGTGGGCGAAGCCGAATTCGACGGTCCTGCCGAACCCGGCGGCGACTTCGAGTA AGGCCAAGCCAGAACTATCCCGCCCCCACCAGCGAAGTAGCTGCAAGGCGGGATAAAGCATGGCTGAAAGATGTTTT GTGGTGTGCATCCAGGGGAAACCTTGGACTAGACTTGATAGCCAAGTGACTAGCCGGTTGCGACCCGGCCCACCATA ACGATGTTAACCTCTACATGAAAAGGAGGCGGGTTCAAGGCAAGGGCTCTCAGTAATAAAGTCCTTCCAACACAGGT CGCAATGGCGATGTGTCGATAGATTCTCGTAGGAGGTCTGTCGATAGCCAAGGTTCGAATCCTTGGGCGGCCGCCAA CTTAGGACGCCTTCATTTTAGCCTGGGCCGGGCTGGTGCGTGCGGGAAACTCTCACCGAGGGCGTCTTAAGTTGGCG TGAGTGAAATAGGCGCTAGGTTCCCGGAAATTTCCTAGCGTCGGGGTTATGAGCGTCAACAGGTCGAAGCTTCAGCG GGCTTAGACCATGCCGGGTGTTATGAGCGCCCGGCACCTTCGGAGTGTAGCGCAGTCAGGTAGCGCATCTGCTTTGG GAGCAGAGGGTCCTAGGTTCGAATCCTAGTACTCCGACCAGAATACAGGTTTCAAACCGAAACGTTTGGAGCTAAAA TGTTTTAACACCTGGCGGTGTTCGAGAGGTTGGCCATGCCTCTCCCGCAGCTGATGGCTGCGGGCTGCGCGTTGGGTTTCATGGGTCCCGCCTCATGTCTCCTGCTCCGGTTGTTCGCCCAACGCGCAGCCCACAGCCATCGACGTGACTGTAC CTCCTCCCAAGTTCGTGTAACAACGGACTTTTTAGGTCTGCATAGAGTAAAATCTATGCAGACCTTTTTCTTTTACG GAGCTGGAATTGAAGACTCACACTGATCGAGCCACCTGCGACTTTGAAACGCGGTCTCGGGCTGACCTCCTTGTAGT AGGAGCTGACAAGTACGCTCGAGACGAGAGCACGGAAGTCATATGCCTTTCGTTTGTGCTGCCCGGAGAGGACCCGG ACAGAGATGGCGTTCATGAGTGGTGGAACCCGTACGTTACTGGCTTTGACCTGCCCAAGGACAATGCCTATTACATG AAGCAGTTTCTCGCATGGGTCAGAAAGGGCGGAAAGGTAGAAGCTCATAATTGGGGCTTCGAGTATGCCATCTGGAA CAACGTGTGCGTGCCTGCATTCGGTTGGGACCCTCTGGCTATCAAGCAAGGTGTCTGCTCGGCCGCTAAGGGCTCGT ATTATGCTCTGCCCAGGTCTCTTGACGCAGTGGCCAAAGCCCTTCAGATTCGCGATCGCAATGGCGAGCTGGTCGAG AAGGACAACGAGGGCTACAAGCTCATGATGTATCTGTCGAAACCCCAAGGTGGCCGCTTCGTCGGCACTGAAGGTGA GTTTCGGCGCCTTATCTCCTACTGCTCAACTGACGTGCGTACCGAGCACTACGTGTCCTGCGCACTTCCTGATATTC CTGCAAAGGAACAGGAAATCTGGGAATTGGACCAGGTCATCAACACACGTGGGCTCTTCATTGACACGGACATGGCC CAGGCAGCATACGATGCAGACCAGGAATTCTCGCAGAACCTGCGTGATAAGCTGCCAGAGCTTACCGGTGGCATGGC CGATAAGCCAACGCAACGTGCCCGTATCAAAGCATGGTGCGAATCTATGTCGGTCCAACTCAAGGACACGAAGGGGA CAACTGTTGACCGCATGTTGAAGGACGAGAATGTTCCGGCCGTGGTAAAGCAAGTTCTCACCATTCTCCGCATGGGT AACCGTACGTCCACAGCCAAGTACCGCGCCATGCTTGACATGGTGTGTGCAGACGGCCGAGCACGTGGCTCGATGAT GTATTATGGAGCCACCACGGGTCGCTGGTCGGGCAAAGGCCTTCAACCTCACAACTTCCCGCGCGGTGATATCAAGG CCACCACGGGGATCAAGGATATCGAAGAAGCCATGGAAGCGGCTCGCCTCGATATCCTCTACGGCCTGGAATGGCTG TCGATGGTATACGACGACGTGGGCAAGCTCCTGTCTGACGCCTTGCGTGGTGCCATATGCGCGCCTCCGGGCAAGAA GCTGGTGGTCTGCGACTTCGCGGCTATCGAAGGCCGTGTACTGCCTTGGCTGGCCAATGACCAAGAGCTATTGGAGG TGTTCCGGAATAACCAAGACGTGTACTGCTTTATGGCAGACGACATTTATGGGTACAAAACTCATAAGAGTACTCAC CCTGACGAACGCTTCGTGGGCAAGCAAGCTATTCTCGGCCTCGGCTTTGGAATGGGCGTCAAACGATTCCTCGCTGA TTTGGCCGAGAAGTTCGATGTGCACCTTCCCAAGAAGTTCATCTCGAACGTGGTCAAGGTTTACCGGACGAAGCGCC ATAAGATAGTCAAGTTCTGGCGTGACATTGAAGAATGTGCCATCACCGCAGTGCAGACGGGTCAGCAGGTGTCGATG CCAGAAGGCAAGCTTACGTGGTACACGAAGAAGTACGAGGGTGTAGGCATTTTCCTGCACTGCCTCCTGCCTTCTGG ACGGTCGCTGTCGTATCCGTTCCCTATGCTGCGGAAGGACGCCACGTATTTCTTCGACGCTAAACGTACGTCGGTCG ATTCAGAAGGCCGATCGGTCAGCGAAAGCGAGTCGATTCGCGTTTCGGTGCCTAACGGTAAGGACTTAGCTATACGA GCTTTCCGAGAGGCTAAACGCATCGCCCAGCTCGAAGACGTAGAGCTACTGGTGTCGCTGCAGGACGTGGTAAACAA AGAACCGTCGTTGAAGTACACTCTCACCTTCATGGCAATGAATGCGACCACGAAGCAATGGGAGCGTACGAGTACTT ATGGCGGAATGCTCACCGAGAACGTCACGCAAGCCGTGGCTCGAGACTGCATGGCATGGTCAATGCTTCGCTTGGAA TCGTTCCCGTTCTATGAGCTAGTATTGAGTGTGCACGATGAAGCGGTTGGTGAGGCCCCGATAGATGATCCACGCGC ATCGTACAAGCACATGGAAGAGCAAATGGCCCTCGGCGAGGAATGGAGTGAAGGACTGCCCATTGCAGTTGAAGGAT GGGAAGGCCGCATGTACAGGAAATAGCATGGACTACAAAATCTTGTTGGAGAAGTATGTAAGCCACGTGCTCCAAAT GGAAGGTACTACTTTCATAGGATGGCTTAATTCTGGGCGTCTTAGCGAAGTTGAGTTCACAGCAGAAGAAGCTGAAG AGCTGAGAAGGATTGGTACCGAACTTGGTGACGATGATGCCTATTAGAACCCTGGTGTGCATCAAAGGCCGTCCGGA AGTAGTTACAGAAGAAGTAGAGGAACTGGATGACTTCACTTCAAAGTATACTGTACTGATGGGTGGCACAACAATTT TGGACCACGTCCGAGGGCATTATTCAGTCAACGGCCGGTGCTTCGAGCAATGTGAAGCTATCCAAATTGAGACTGAC GCCCTAGACTACGGCTCGATATTTAAGAAAGCAGACGAGGCAATTCGCAATGGGACCATACGAACCCGTTTTTGAGC ACTACAAGCACCAAGCGCGTGAGTTCGAGTTCCGCAATGAACCATCCCGCGCGCTTCTGTGGCAGATGCGGACTGGA AAGACAAAGGCCATGATCGATATGGCCTTTGCCCTATTCATGGACGACAAGATCGACCAGGTACTGGTGCTAGCTCC GAACGGTGTACATCTCAACTGGGAAATCAAGCAACTTCCGGTCCATGCCTGGAAGTCGTTACCCTATACGGTTTCCT CCTGGGTGTCCTCGATGTCCAAGAAGCCAGAGTACTTGCGTCGGCTCAACATGAACACCCTCAATCCCGTTGGTGCT GCGAAGAACAGTCTGCGCTGGTATTGCATGAACTCCGAGAGTTGCTGGCGTGATCGACCCAAGAAGACCTTGTCGAT GTTCCTCGGCCAAGCTAAAAAGGGCACGCTGTTGATCGCGGACGAGAGCGATGACTTCCGTAAGATAAGCTCCAAAC GGACGGCCTTGGCTATTAGCCTGCGAGACCATGTACAGTACCGCAGGATTCTAACGGGCTCCTTCGCCGACAACTCA CCTCTGGCAGTCTACTCGCAGCTTGAGATTCTCAAGAAGCACGCTCTCGGGTACAAGACGTATGCAGAATTCGAGGC GCACTATGCCGTGTACAGTAAAGCAGCCATCCATGACCGCCAGGGCCGAGCTCGTCACGTCAAAGTCATTGAATCCT ACAAGAACCAAACCGAGCTGAAGGAGCTGGTGGCTCAGTACGCCTCAGTGGTGCTTCGAGAGGAATGCGATGACATG CCAGCTCTTGTGCATGCTGATGAGTACTTTGAGATTAGCCCAGAGCAGCGGAAGCTATACGAGCACATATCAGACAA GATTCTGGAGGAGGAAGGCCTGCATGGTGGAATCATCCTCACTGACGTATTCTCTGGTGGCGTCAAGGGGATCAAGC TGCAGCAAGTCACCAACGGATTCTTTGTGGACAGCGAGGGCGAGGTCACCGATTTGCCAAATCCCCGTGGCGAAGTC TATGCCCGTGTCATACAGGAGCAAATGCTGGACAACCGTCAGGTTATCACGTGGTGCCGCTACCATGAAGATATCAA ACGGGTAAAAGCCATCCTAGTTGACTTGGGCATCAAGTTCGTGGAATTCCATGGAGGCATATCCACGCCGCAACGCA TGAAGAACATGCATACGTTCATGACTGACCCTAGCTATAAGGTGTTCATCGGACAGCCGGCAGCTGGTGGGCGTGGT CTTGATCTATCCGTGGCTAAGACAGTTATATGGTATAGCCATACCTATGACTTGATCCACCGGCGTCAGGCGGATGA ACGAGCCACGCACGTGGGTGGGCATGCGATCGACGTAATTGATTTGCAGGCACTCGATACCGTAGACCTCTCTATAA TAGCTTCACTGTCTGAGAAGACAACAGTATCCGACTACTTGAGCCGACACGGATTGCAGGCCTTTCTAGCAGGCAAA ACGCAGGTTTAACGGATCGGAACATAGAGCTAATATCTAGTTACACCATCTCTGATTCACCACCCAGTCTCTTTTTAAAGGACCGCATCATGACCGACACGACCCAGACCGAAACCCCCGAAACCAAGGCCCCCAAGGCCCCCGTCCGCAACAT CAGCGCCGTCGCCCGTGAAGCCATCCGCGCCGGCCTGTCGAACGCCGACGCCCTGGCCTCTGTTTCACTTGTTGCTC TCCGCTGGTTGTCCACATTCGAGGATTCGGCTATAATATCCTTAATGACTGAACAACAAGGAGCTCGAAATGTCTGT GGTTGGAGAAGTAAGGATAGAGGAAGACTATTGGAGTCGAGGGCACTTTTATGAAGGTAAAAGAAAAGAACCTAGGC TCTTTAAAGAGTTTCAAGACTTGGCAAAAGGAACCAAGTTGCTTGCTGGAGCAGAAGAATGTGAAGACTGCGGCAAT GGCACCGCTGGTTCTGAAGGAAGCCCCAAATGGTGCTGCTATTGCGGCGCGCGTCTTCTCTCTGGTAAGGAATTCAA ATGACTGCACCCTCTTACGAAATGATTAAGGACAACTTCGGTTGGGCCCGTGTGTACTGGGCTCGTGGTGACTTGGA ATCGAAGTCAGCACGTGTGAACGAGGTGCAGAATCCCCTGGTTATCGGCTGGAGCCACGCAATCATCATCGACGGCG CCAAGCAGTGCACGATCTTTTGCCCGTTCACCTTTCAGTCCTACCAGGTCTCGAAGCGGTCGGCCGAATATGCCTCT CTGCGGACGCCCGAACAGCGCCTGAACCTCGTCACGCTGACCACGCACCTGCTCAAGAAGTGGGCCATTTGGGTCCA CCTGGGCATGCGCCGTGACTTCGGCATGGCCGCAATCATTCTCAAGGCCTTCGGCGTTGAGCCGCCAGTTACAGAAC TGTCTGCTGGCCTCGAATACGACGACTTTGGCGATCCCATCGAGCCGAAGACGGAAGGAAGTCGCAAGGGCAAGCAG TCAGAAGAAGAGCTGAAGAAGCTGGTAAAAAGGACCTCGAAGCGCGGTGAAGTACTCGCGTGGTTCTTGGAGGACGG AGGTGGGCCCAAATCGGTGCACGCGGCTATGGCCGTGTTCAAGACCACGCGCTCGAACATACTGAGCCACCTCTTCA TTCTTCAGAAAGATCACGGTATTGGTTATTCCCTTGCCAACAATACTGCGACCGTCTTTGTACCCGGCAAGGTTGAC CCGTTCCTCAAGGAAGAAGCATGACCTCCCATATTTACCCCGACAGCGAAGCCCAAGAACTCTTTGATGCCCAAAGG GCCGTCAACCTGTTCAATGAGCGAATCCTCCAAGTGCCCACCGGCACGTACGAAGAGGCCAGCTGGATCGAAGATCG CCGGCTGCAGCCGCGGCTGTTGGACGGAGTGCGCATGCACGCCCGCATCTCCCATTTGCAGGAAGAGCAGCTCGAGC TGGCGCAAGCGTACATCGCCGGCGACATCTGCGAGGTGGCGGATGGGCTGATGGACCTGATCTATATTGCACTCGGC ACCCTGTCCGAGATGCATATAGACGCTTCGCGGGTATTCCATGCCGTACACCAGGCTAATATGGCTAAGGTCAACGG CACGGTCGCGAAGCGGCCTAACGCCGGCAACCATGACGCAGTTAAGCCAGAGGGCTGGAAAGCCCCGGACATTCACA AAGCTATCTATGGAGAAAGCTAAAATGATCGAGAGCTTCCGCACCCTTGATAACTATATCAAGCACGTGCAGTCCCA AGCTGGGTACACTCTTGTCGAGTCTCAAAAGACGCGCCTGGAAGTGGTGTACCGGCAAGGTGACACCGAGGACATGA TTCGGGTCGCCAATGAAATCATAAACGCGGGCTTGCCGGCAAAGGAGTCCATCGGTCAACGTGGCGCTTTCGACGAC CTGAACAAGCAAGCGCAGAAGCAGACGTCCGAAGAGCTTGTCGATAGCCGCAAAGCGCTCTACGGCACCTTCTGCGG CCGTGCAGAGCTGACGGCTGACCTCATGGAACGGCTGCAGCAGCATCCCAAATGGCCGAGCATTCCGGCCTGGGGCA AGTGGGCTCTCATCATGTTGGTCGAGAAGATCGGCCGCATCATCGAGGGGGATCCGAAGTATGACGACAACTGGAAG GACATCGGCGGCTACGCCGAACTTGCCCGCCGCAACGCCATCGGAGAGAAGGCATGAGCTTCGCTAAACAGTACCGC AGCATCATCACTGGCATGTTGGCAGGCTCCAACATCGTCGAACAGCACAACGAGCGCACTGGTGAAGTGATTCGCAC CATGCCAGGTGGTCTGTCGTGGGGTTTCTGGATAGCCAACCGTATGGCGCCCATGATCGACTTGCGTCGCACGTACA TCAAGACGGCGGCAGCCGAAGCCGCCTGGTTCCTCCAGGGCACCCAAGATACGAGCTGGATCAAGAAGCACTGCCGT ATCTGGGAAAAGTTCGAAGAGCCCGTGGGCTTCGAGCTGGATGGGCAGACGCAGATGATGGGCGTGAAGAACGCGTA CGGCTACCGCTACCGCAACCACTTCGGGCGTGATCAGCTGCTGGACGCCGTGAACGCTTTGCACATGGACCCGACCA ACCGTCAAATCTATATCTCGGCATGGGACCCGAGCCGCGACGGTCTACTGAACAAGGGCGAGAAGAACGTGCCGTGC CCGGCGTCGTTCACCCTCAACATCATCAACGGCCAGCTGCACTCGTCCTACTTCCTGCGGTCGTCCGACTTGTTCGT GGGCTTGCCCTACGACATGCTGACCCACTCGCTTCTGGTGACGGCAATGGCCGATACTCTGGGCATTCAGCCGGGGT TCATCTCCGTGCTGGTTGGCCATGCTCATCTGTACAAGAAGCACCAGGAAATGGCGGCGGAGGCCCTGAAGCGGACC GATGAAGCCCCTATGATCTACATGGAACGCTTCTCCATGTCCGATATCGAGCGCGAACCGGACGACTACGTGGCCCA CTACAACGTCGCGGACAGCCGTGCCGTGCATCCGCTCTTCAACTGCCGTCCGGAGGTGGTGGCATGAGTAAAATCGA CTGGGGCACCGTGGCTGTCAAGCCGGAGCAGACGTCTCAATTCAAGTGGGACAAGCGCTTCATCCAGATGGCCCATT TGGTCAAGGGCTGGTCGAAAGATGATCGTCCAGTCGGGGCCGTCATCGTGCAAGACCGCCGTATCATCGGCATGGGC TACAACGGCTTCCCGGAGAAGGTAATTGACCTGCCGGAGCGCTATGCCTCGAAAGAACTTAAGCGTGGGCTGATCGT GCATGCCGAGCTCAATGCAATCCTGCACGTGGACTCCAAGTTCCTGCTGGAAGACGCGACGCTCTATGCCACGCGCT TTCCTTGCAACGAGTGCATGAAGACCATCAGTCAGGTCGGCATCGCTCGTGTGGTAAGCCCCGGCCCTGAAGTAGAT CATCCGGTGTGGGGCGAGAGCCACCGCTTTTCGATGCTTCTGGCACATGAGAGCGGCATCGAGCTGGTGGAAATGAG CTGATGGCAGCCAGCCCGAAGATCGCCGAGACGGCCCTATGGAAATGGGTCCGTGAAGGTAAGGCACACTTTGGGCG TGACCTCCACATCCAACGGATCGAGAGCACTACGGGGCTCGGAATCCCGGATGTGGAGGCATGCCTAAAAATGTGGC CTAGCAGCATATCCTTCTGGCTTGAGCTCAAGGCGGTGGCTCGGCCAGCTCGGGAATCAACTCCCATACGCCATAAC ATCACCGCCGAACAAATAGCATGGCACAGGAACCGCTACCACGCTGGCGGACACTCGTACGTGCTACTGCAGATAGG TTCCGGTCATGAAAGCAAAAAGTACCTCATCCAAGGTTCAGAACTCCTGGCCTTTCAAAAACCCATCACGGAAGAAG AAATCCGGGCCTGCGCACGCGAAGCAACGGACTGGACGCCACAAAGACTGCTGGATGCGTGCGCGCGTCCTAAAACC TAAAAGGACCCTACACATGAAATTCATTACCCACAGCTGGATCGGCAAGGCCCGTGTGCTCTCGTTCGACAGCGAAG AGACCTACTCGCGTTTCATGGAACGCTTCGGCTATCTCGGCGGCATGCGCGAAATCTCCAATGAAGAGGCCCTCGCT ATTGTCATCAACGAGGGCCAGCCGGCGGATGTCAAGTCTGACTTCCGCTCCCATCTTCACGTCACGCCTACAGCTTT TGAAGCCCTTGGCGATAGCCAAGTCCCGTCTTCCACGTAAGCACCTCGCGACGAGGATTGCCGGCCCGCAGCCCAAA GTGCACCCACGGGCTTTGCGGGCCGATTTCGTAGATGAGTTGGTCGAACATGATGTTCGAAGACGAGATGGCCTTGC AGATTTCATACGGGGAGCCGTACGCCGGACACACCAGGTCGGCTGCGAGGCCATAGCGGTGGGCCGAATCGGCGACGCCGCCGACAGCCTTGTTCAGGGCGTCACCACGGTAGCCCGAGGAAATGATGATGGCCTTGCCACCCAAGAGGTTACG CACCTCTTCCAGGGACTGTGCCAGGCGCAGCAGGTTGGCCTTCTCGGTCTCGTTCGGAACGTTCTTGATGCCACGCG CGATCGCCGTGTCCGAGTGGATCAGCTCTTCCAACGTGAAGTGTGGGGTAAGGTTCATTTCTTGCTTTCCTTGGTTA CAGAGGCCCATCCTTGGACTTCTCGGATGGTTTGGGTGTACCGGTCAGCATCTGCTGCCACTTCTCGGTATCGGTCG AGAACCTCTCCAAGTACCACCCAGGCGGAGGCACCGGCACTGACACTGATGCCGGCAGACTTGGCGAGCGCGGTGGC GTTAGCGGCCTCGGTGGCAATGGACTCCCGCAGCCGGAAATAATTGCGGTTAGCAGTAACACCAATATGGCGCGCAT GTTCAAGCTCCTGGGCATGCTTCTGTTGTTCTTTGGCCCAAGCGTCCTGCCACTCCATCTCCTTGAGACGGTTGGTT TCGGACTGGGCTAGGGTGGCTTCAGTCTGTTCTGCCACTGCTTTGGCGTACCCGCGGGCTTCTGCGGCCCGTATGTT GGACGAGTAGAACCACCAGGTTACGGCAACAGCCGCAAGCGTGGACAGGATATAGACCTTAGGGCTTACTGCCAAGG CCTGCTCCTTTCACCGCCGAGTTGACGACGTTAGGCGGTATACGGTTGAGAATGGCATCCAGCTTTGCATTCGCGTC TTTGACGCGGGCGTCAGCTTCAGCGCGGATGGCCGTGATACTGTCATCATAGACCTGTTGCATGCGCTCTTGGTCAA CAATGGACTTACCACCCAGCATTGCCAGAGTGAAGCCCACACCAGCCAGCACGGATATGGACATCATCAACCAGAAG TAGGTGCGTTCAAGAATAGCGGGGTGCTTTACCCCAAATCGGCACAAGGCCCTATTGATCTTGTTCGACATGGTTTT TCTCCACTAGTAGGAGGTAGTATTTACTCCGCCACCTCTCGGTTTCCTCTTGCTGCTCTTTGAGCTGGGCTATCAGG GCTTCATTGGCCGTAGTAAGGCGCTCAACGAACGAGCCATAGTTACCAATAACCGATAGGTTTCCAGACAGGTCCGC TCTTTGAGCTTGGTCCTTAAGGGCTAGGCTCTGAATCAACCTGATTCCAGCCGCTGCCAATCCGGCCGCGATTCCAC CACCGAAGACCCATTGGAGTATTGTGATTTCTCCCACAGGTACCTCTTTTCAGGTTGAATGTAGGCAACTTTCGCTG CATTTAGTGCTTAATTATACGCGTGGGCGATTATCGATCAGCCAGCGGTTACAAAGCGCTGGTATCTAGGATTGAGG CCTAGCTCTATAATGAATCATGCTTTGAACGGAACAACAGTATGAACAGACGACCGAGAATTCTGGACTCAGTTCGC TGGAGACCAGGATTGCTCATAGAGGATACACGGCCTAATGGCGAAACTCATGGTGTGCCTCTTTCGAGCTGCTCAAA CCAAGTAATCAGCTGTGTAGTTCTAACCGAGATAACATTACGGGCTATGTGCAAGCCCAAGGAGAGTAAGAAATGAA AAACCTCAGCCACCCGAACTGGTCCGGCCGCTCGTACCGTTCCTCGGATGAAGCCTTTGGTACGAGCAGCCTCTACC TGACACCGAAACAAGTCCGACAGTACAGCAAGGAAAATCCGCTGCACTGGTTCCTCGGCGTCATCCTGCTTATCCTG CTGGTGGTGCTGTGCTTTTTGCCCTTCAACGCGAAGGCCACTGAAATTGAAGAACTGGGAGGTATCGATTATGTCCA ACGTTCACTCGATCGAGTCATCGTTGTCTCGCCCCGCGCGACCTTTTCTCTCCCCGCTCCACGCGGCTCTGGTCAAA CCTACGTCCACGTCTCCGTTGAGCGGGTCAAAGATCGAAAACTGGATTATGGGCCTGGGTATCGCAACGATGCTTGC GCTCAATCTGGCCATTATTGCGGAAATCTGCGGCCTATTGAGCCGGATCCATATGAAGTGAAATGACAAAAGGGGCC TCGGCCCCTTGTCTTATATGTCAGTCACATCAATAACTAGAAAGCTGATATGCGGGCTTTGACCCACGGTACCGGCC ATTCCACCAGGACCGTCCCACAAGATAGGATCATAGTCATCGCGCTGCTCCACGCTTACGGTAGTGCCGTTAATGTT CCAGTAGCAGGATCGCCACCGCGATTCATATAGCCGTGATCCATCGCCCATGCCGGCGTCACCTCTATCAATAATAA TCGACAGTCCGCCCCAAGATATAGGGGCAATACGGTAGATACGGCCGGCTGGGTACGTACGTGCCCAACCATTGGTG GCTCCATATACTGCATCAGTGACTTTGAGAATACGAAGGTTATGCTGCCATACTATGGCCCCTGTATTCTCATTCCG CACACGAAGGCCGGGTACGCCACTGATAGCCTGATGCCCAGCTTCCGTCGGAGACTGAAAGAGGTAGCAGTAGCCCC AATTCCATCCGAAATATGGACTGTCAAACAAGTTGTCTGACACGATCAAGCTTCGGGCTGTGGTTCCTGCTGGTGGA GGACTGTTCTGGGTAAAAGGGTTACCAGGAGACATTTTCCCCCAGTTAGTACGAGGGCCGCGAGCCACGAGGTTTGA GTAGCTCGGATCAACCTGGAAGGTTCCGGCGTCATTCTTGGACCTAAGGCCAATCATCAGTAGACTCCAAACATGAG AGCCCAGACGTAGCCGGGCGGCAGAGCCTGGTTGGGCCCCCAACCAATGCTCCAATAGATATATTGCCCTGACTTGT ACACTGACAGCGAGTTAAGCTGTGCCAGGATGTTTGTGTCAGGATATACAGCCGTATTGTTGGTAACCCCAATGCGA TAGAATAACTCGCCTTGGGACAAACCGGCATTGAAACTGTTACCAGAGTTGGCAGTGAAGAATATGGTGTCAAGGAC ACGTCCTGCCCGGTAGGACGTGTCCATAACAATTCTGCCGCTATTAGGGTCACGGACCCGAAGACCAGTAGCCATTT AAGTCAAAAGCCCCACTTCTACGCAAAGCACACCGGTATTGGTGTTCCACACATACAAGCCAGTGTTGGTTAGTCGT ACGCGATACCCATTGCCAGTGCCGTTCATCTCGAGGCCCTGAGCCCCCTTGTGGAGACGCCATCCAGACACGCCCGA CACAAAGTCGTTGGACTGAATGATATCACCAATCATCAAGTTGGTAATGGTACCATTCTTAATGAAGGCCGTGTCCA TGTACACATTGCCATTATCAATTATAAACATGGATTTGAAGGTGCCAGTCTCATCGTCAGAGCGACCCACCGCAAAA CGGTCAGCCAATACAAGGACTTGAGACTCGAGGACGCCTTCATTGTTTTCCACCCCGACACCGATACCCGCGAGGGC CGTACGGCCACCCGCAGTCAGCTGGGTCTTGATGGTGTACATGGCAGCCAAGGCATTCTGTATTGCCTCGACCTCGA CGGCGGCACCACCCCCGGATTCGATCTTGGTAATGAGGGCTTGCGCGAGCTGCGTTTCCGTTATTTTACCATCAAGG TACTCCATGATGATATCGGCCTGATCGCTTGAAGAGCCCAGCAAACCTACACCAGCATTGTACCAAGGGCCAACGCG GCCTGCTTCGTCAATAACCCGGAACCAGAAATACCGCTTCTGACCCGGTCCGAGGTCCGTGACAGCAAACTTGTTGG CGGGCAGCGGCAGCTGGATCAGCTTGGAAGCATCGCCCAGGATGTTCGTCGTGCCCCAGTAGATTTCCAGGGGAAAC CCCTCCCCTTTCTTTTGCCTCATCACACCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGCCGTCGTGGCAGCCACG ACAACTGGCCGAGTATGGTAGACCCATCTCGGCTTTCCGCGGTGTGAGAGACCAACATGTAACCAAATGTGACGGTT ACAAGTAGTTACAATTACATCTAGTTACAAGTTACACCCAGTTGCATCTTTGCAACTGGGTGTAAGGAGATGTTACA GACCGCACATGCTACGGATTTCTTCGAGAGTGTAATTTGGGTTACTTTCAAACACGTTCAGTTGCGAGTTGTGCTCC ACAATACGGAGTACCTCTTCACGTGTCAGATTGTAACAACCCATTGCTTCTTGCAAATCGTAACCAAACCTTCCACA ATCTGAAGTGAAAGGATCAATGATGAAGATGCCACTATCTTCATCCATGAAGCCCAGTGCTTCAGTCTCGAGCATGT TACCATCCTCATCGAAGGTAGTGCCAAAGCCAATACGCAGTTCCATGTCTTGCTCCAGTTGTTTAAGTCAGTATAGATATTGTACCTCAGTATTGGAGTTCAAACGCAACATAAGGGCAAAAGAGTGTAACAAGGTGCAAGTGGCACACAGTCA CATCTCCTTGCAGACTGTTACACTTTTCCCATGTACTTTCTCATAGGTCTCAAGTATAATATCTATATTGGTTAACA CACTGGGAGCAAGACATGTCTGTAGTCTCTGATATCTGCAGCCTCACTGAAGTGCGTGATTACATTTGCAACAACAT GGAATGCAGTGACGAGATGCAACGCCTTGTATCTCAGATCGAACTTCGCATTGCGGAACTGGAGGAGAGCAACGACT TGTAACGGGGTCTACACGGCGTAACGGGCCCCTAGGGGTCTGTAACATGGCGTTACGCCCACCGACCTCCTCGATCA AAATTTTTGTAAGATTTTGGGCTGGAGGTCCCAGTTGGAGCTTTTTTGTAAGATTTTGGGCTAGAGGTCCAAGCTTG GTATAAGTCTTCAAGCCCTTAAAAAATTTTTTCAACAATTTTCGCTGGCTTACAGTCCCATTGTTTAGCGTCACAAT CAGCCCAATCTACAATCATAGGCGGTGACCATGAGCTACACGTATGAGGACGAGGAAGATACTCGTCCACCTGACCA AAGCAGCCACCAAAACAGTCAAACGGCTGAGCCACCCAATCCGCACGGATTTGAATCCCGCTTGCTACGCCAACAGA AGGAGATCTTCCTCGATAACCTGTCGATGAATGGCAATATCACGTTGGCCGCACGAGCTGCCGGATGGAAATACCCC ACCGTTGCTGAACGCTACCGTGCCGAAGATGAACAGTTCGCTGAGGCGTGGGTCGATGCGTTGACCCAGGCTACTGA TGCGATGGAGTACGAGGCACGACGCCGCGCGATGGAAGGGTGGGATGAGCCCGTTTGGTACATGGGCGAGCAAGTCG GGACTGTCCGGAAGTACTCCGACCGGCTGCTTGAGATGATGTTGAAGGCCCATCGCCCCGGACGATTCCGCGAGGTG GCTCAGGCCGACAATACCACGCCTGGCGTGCTCGTGATTACTCAACCTCAAGGCCAATCGGCCGTTGAATGGGAAAA GAATGCTACCCCGCAGCAGCAGCACCTCCTCCAGCGCACGGTATAAGGAAGTCTGGCGCGCCCAAGAGGGTAGCCAG GAGCTCTTCCTATCGTCCCCGGTGCGCGAGACGCTGTACGCCGGCACCCGCGGCCCTGGTAAGACTGATGCCCTATT GATGGACTTTGGGCAGCACGTCGGCCAGGGCTTCGGCGCTGAGTGGCGGGGCATCCTTTTTCGCCAAACACTGCCAC AGCTGGACGACGTCATCAAGAAGTCGCG...

Claims

WHAT IS CLAIMED IS:

1. A pharmaceutical composition comprising one or more strains of Achromobacter phage and a pharmaceutically acceptable carrier, wherein the strains of Achromobacter phage are each selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07.

2. The pharmaceutical composition of claim 1, wherein the composition comprises two or more genetically distinct strains of Achromobacter phage, each strain selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07.

3. The pharmaceutical composition of claim 1, wherein the composition comprises three or more genetically distinct strains of Achromobacter phage, each strain selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07.

4. The pharmaceutical composition of claim 1, wherein the composition comprises four or more genetically distinct strains of Achromobacter phage, each strain selected from the group consisting of phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07.

5. The pharmaceutical composition of claim 1, wherein the composition comprises the phiACH01, phiACH04, phiACH05, phiACH06, and phiACH07 strains of Achromobacter phage.

6. The pharmaceutical composition of any one of claims 1-5, comprising about 5×105pfu / mL to about 5×1012pfu / mL of Achromobacter phage.

7. The pharmaceutical composition of claim 6, wherein the composition comprises about 5×107pfu / mL to about 5×109pfu / mL of Achromobacter phage.

8. The pharmaceutical composition of claim 7, wherein the composition comprises about 5×107pfu / mL, about 5×108pfu / mL, or about 5×109pfu / mL of Achromobacter phage.

9. The pharmaceutical composition of claim 8, wherein the composition comprises about 5×108pfu / mL of Achromobacter phage.

10. The pharmaceutical composition of any one of claims 1-9, further comprising a pharmaceutically acceptable excipient.

11. The pharmaceutical composition of any one of claims 1-10, wherein the composition is a liquid composition.

12. The pharmaceutical composition of claim 11, wherein the composition comprises a saline solution.

13. The pharmaceutical composition of claim 11, wherein the composition comprises a phosphate-buffered saline (PBS) solution.

14. The pharmaceutical composition of any one of claims 10-13, wherein the excipient comprises a preservative.

15. The pharmaceutical composition of claim 14, wherein the preservative comprises magnesium or sulfate.

16. The pharmaceutical composition of claim 14 or 15, wherein the preservative comprises magnesium sulfate.

17. The pharmaceutical composition of claim 16, wherein the magnesium sulfate is present in the pharmaceutical composition at a concentration of 10 mM.

18. The pharmaceutical composition of any one of claims 1-17, wherein less than 5.0 endotoxin units (EU) / kilogram / hour are present in the composition.

19. The pharmaceutical composition of claim 18, wherein the pharmaceutical composition is substantially free of endotoxin.

20. The pharmaceutical composition of claim 19, wherein the pharmaceutical composition lacks detectable amounts of endotoxin.

21. The pharmaceutical composition of any one of claims 18-20, wherein the pharmaceutical composition is sterile.

22. The pharmaceutical composition of any one of claims 18-21, wherein the pharmaceutical composition is substantially free of exotoxins.

23. The pharmaceutical composition of any one of claims 18-28, wherein the pharmaceutical composition is substantially free of virulence factors.

24. The pharmaceutical composition of any one of claims 18-23, wherein the pharmaceutical composition is substantially free of antibiotic resistance gene products.

25. A method of treating an Achromobacter infection in a subject in need thereof, the method comprising a step of administering the pharmaceutical composition of any one of claims 1-24 to the subject.

26. The method of claim 25, wherein the step of administering comprises systemic administration.

27. The method of claim 25, wherein the step of administering comprises parenteral administration.

28. The method of claim 25, wherein the step of administering comprises intravenous administration.

29. The method of claim 25, wherein the step of administering comprises enteral administration.

30. The method of claim 25, wherein the step of administering comprises oral administration.

31. The method of claim 25, wherein the step of administering comprises respiratory administration.

32. The method of claim 31, wherein the respiratory administration comprises administration by inhalation of an aerosolized form of the pharmaceutical composition.

33. The method of claim 25, wherein the step of administering comprises local administration.

34. The method of claim 33, wherein the step of administering comprises topical administration.

35. The method of claim 33 or 334, wherein the step of administering comprises administration to one or more infected sites within the subject.

36. The method of any one of claims 25-35, wherein the administration comprises administering more than one dose.

37. The method of claim 36, wherein the administration comprises thrice daily, twice daily, daily, twice weekly, weekly, or biweekly dosing.

38. The method of claim 36 or 36, wherein administration comprises administering multiple doses over a period of at least 7 days.

39. The method of any one of claims 25-38, wherein the Achromobacter infection is a chronic Achromobacter infection.

40. The method of any one of claims 25-39, wherein the Achromobacter infection is present in the subject’s lungs.

41. The method of any one of claims 25-40, wherein the subject is afflicted with or at risk of developing a chronic lung disease.

42. The method of claim 41, wherein the chronic lung disease is selected from the group consisting of bronchiectasis, cystic fibrosis, emphysema, interstitial lung disease, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and pulmonary hypertension.

43. The method of claim 42, wherein the chronic lung disease is cystic fibrosis.

44. The method of claim 42, wherein the chronic lung disease is bronchiectasis.

45. The method of any one of claims 25-44, wherein the subject has received a lung transplant.

46. The method of any one of claims 25-45, wherein the subject is immunosuppressed.

47. The method of any one of claims 25-46, wherein, prior to administering the composition, the Achromobacter infection is confirmed to be susceptible to at least one of the one or more strains of Achromobacter phage in the composition.

48. The method of any one of claims 25-47, wherein the Achromobacter infection comprises one or more species selected from the group consisting of Achromobacter xylosoxidans, Achromobacter denitrificans, Achromobacter ruhlandii, Achromobacter piechaudii, Achromobacter animicus, Achromobacter mucicolens, Achromobacter pulmonis, Achromobacter insolitus, Achromobacter spanius, Achromobacter deleyi, Achromobacter aegreficans, Achromobacter insuavis, Achromobacter anxifer, Achromobacter dolens, and Achromobacter marplatensis.

49. The method of any one of claims 25-48, wherein the Achromobacter infection comprises Achromobacter xylosoxidans.

50. The method of any one of claims 25-48, wherein the Achromobacter infection is resistant to at least one antibiotic class.

51. The method of claim 50, wherein the Achromobacter infection is resistant to at least two antibiotic classes.

52. The method of claim 50 or 51, wherein the Achromobacter infection is resistant to one or more antibiotic classes selected from the group consisting of β-lactams, β-lactamase inhibitors, aminoglycosides, diaminopyrimidine antimicrobials, fluoroquinolones, polymyxins, sulfonamides, tetracyclines, and combinations thereof.

53. The method of any one of claims 25-52, wherein the subject is receiving another therapy.

54. The method of claim 53, wherein the other therapy comprises antibiotic treatment.

55. The method of any one of claims 25-54, wherein the administration results in improvement in the force expiratory volume in one second (FEV1) relative to a baseline level in the subject.

56. The method of any one of claims 24-54, wherein the administration results in reduced levels of Achromobacter in the subject.

57. The method of claim 56, wherein the administration results in non-detectable levels of Achromobacter in the subject.

58. The method of claim 56 or 57, wherein the levels of Achromobacter are detected from sputum or nasal swab samples from the subject.

59. The method of any one of claims 25-58, wherein the administration results in reduced susceptibility of the Achromobacter in the subject to one or more classes of antibiotics.

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