Method for preparing herbal plants toothpaste

Abstract

In this invention, three herbal plants were used with an extensive range of benefits and features that make them unique: Clove, Frankincense, and Caper. Preparing a toothpaste that contains in it`s composition herbal plants with good medicinal value, such as Clove, Frankincense, and Caper. In general, these materials combination have a very significant impact on the safety of the teeth and gums in particular and the oral cavity in general. It is possible that this preparation can be produced industrially as a modular production to be accessible to the consumer at a time; the world is witnessing a great trend towards the use of medicinal plants.

Description

DescriptionTitle of Invention : Method for Preparing Herbal Plants ToothpasteTechnical Field

[0001] The technical field of this invention is related to the production of toothpaste by Herbal Plants.Background Art

[0002] Historically, Cloves had been used in traditional Chinese and Western Medicine as a pain reliever in dental emergencies, (Sachan, A. K., et al 2018). Cloves act as an Antimicrobial, Antioxidant, Antiviral, Antiparasitic, for igestive Disorders, and as an anesthetic, (Gloria, A. O. 2021 ), Figure 1 Tree Cloves, their leaves and flowers, (Flora Fauna, 2024).

[0003] The Scientific name of Frankincense is Boswellia, it is a small tree or large shrub up to 20 feet tall, it can be single or multi-stemmed and has branches characterized by peeling, (Hidayat Hussaina, 2022), it is essentially a resinous substance, and chemical examination of Frankincense Resin revealed that it contains more than 200 different natural products, including Tetra and Pentacyclic Triterpenoids, Diterpenoids, Polyphenols, essential oils, and Tannins, (Ahmed Al-Harrasi, et al, 2018).

[0004] Frankincense is well known for it's therapeutic effects against human diseases as an analgesic for dental infections, in treating Dysentery, Vomiting, and Fever, as a Liver Protectant, Antioxidant, Anti-Alzheimer’s Disease, Diuretic, Anti- Coagulant, Anti-Inflammatory, Heart - Protective, Anti-Stomach Disorder, and combats Cancerous Tumors (Carcinoma and Glioma), in addition to Bladder and Brain Tumors, (Shaden A.M. et al. al, 2023).

[0005] Capers, is one of the most widely used medicinal plants around the world and it's scientific name is Capparis spinosa, (Benzidane N, et al 2020), it is considered as one of the perennial shrubs that tolerate high summer temperatures in the areas where it is widespread. Figure 3 shows the Capers shrub, it's leaves and flowers, (Noel Mathews, 2024).

[0006] The plant is known to be rich in vitamins B1 , B3, B6 and B9 and moderate in vitamin E, the buds of the plant also contain a good amount of vitamins A, C and K. Minerals are abundant in the plant, the most important of which are Calcium, Ferrous , Potassium, Phosphorus, Magnesium, Zinc and Manganese, which play a very important role in maintaining proper metabolic activities in addition to fiber with a small amount of fat.

[0007] Capers produces various Secondary Metabolites, including Alkaloids and Phenolic Acids, in addition to rare Primary Metabolites such as Nucleosides and Nucleic Acids, (Annaz H, et al 2022).

[0008] A toothpaste was prepared by mixing the following materials: Virginia Creeper Allium Cepa, Neem Azadirachta Indica and Tamarind Tetrapleura Tetraptera. Assessment of the product showed that it has a suitable pH of “7.30-8.10” and strong Antibacterial and Antifungal ability with inhibition halos ranging from 4 to 18. These properties can be linked to different Phytochemicals such as "Phenols, Flavonoids, Saponin Alkaloids, Oxalates, and Tannins" that these plants contain, (Oluwasina, et al, 2023).

[0009] In a separate work, a group of authors prepared toothpaste by adding oil extracted from the plants "Wild Thyme Dubium Origanum and Cinnamomum Cassia" , they noted that adding the oils of these two plants increased the efficiency and effectiveness of the toothpaste against Streptococcus mutans bacteria compared to the paste that did not contain the oil extracted from them, (Karadaglioglu, et al, 2019).

[0010] In another research work, seven types of toothpastes were tested with a content of medicinal substances, namely Theobromine, Aloe Vera Gel, Miswak, Propolis, and Sugar obtained from the outer shell of Shellfish "Chitosan", Enzymes, and Probiotics. Probiotics are beneficial bacteria found in some natural foods and drinks similar to those beneficial bacteria found naturally in the human body, in addition to a toothpaste with a regular content, "traditional chemical component" were used to determine their effect on three types of highly virulent bacteria present in the oral cavity, which are: Streptococcus mutans, Streptococcus sanguinis, and Enterococcus faecalis.

[0011] Using Agar-well Diffusion Method to test the antimicrobial effect, the inhibition halos that formed around the toothpastes were measured after 24 hours of incubation, and the collected data was analyzed statistically.

[0012] Toothpastes containing Theobromine, Chitosan, and conventional toothpaste showed antimicrobial activity for all bacteria tested, while toothpastes containing aloe vera, miswak, and propolis were only effective on S. mutans, and toothpastes containing probiotics and enzymes showed no antibacterial effect Among toothpastes with natural ingredients, toothpastes containing theobromine showed the highest anti-S. mutans efficacy, while toothpastes containing aloe vera and propolis were less effective (P < 0.05), (Demir, S. et al, 2021 ).

[0013] It has become clear that many experiments preceded this work, in which natural materials with a broad spectrum efficacy on germs were used, regardless of their type. These experiments were mature and served their desired purpose. In the current work, three medicinal plants were used that have exceptional biological, nutritional and therapeutic qualities, they are known worldwide and no one disputes them.

[0014] Perhaps describing them collectively as providing complete protection for the mouth, teeth and gums would be unfair, as it is known that the mucous membrane lining the mouth absorbs it with great effectiveness all the substances that pass through it, due to the abundance of their blood supply, it becomes certain that all the therapeutic properties mentioned in the narrative of the three plants become part of the body’s system of absorbed substances and thus create a good immune and therapeutic base, especially if the method of brushing the teeth with toothpaste is adhered to at a rate of three times a day.

[0015] On the other hand, it can also be said that the selection of these medicinal plants combined into a unified mixture has never been seen in the industry before in any country in the world through our follow-ups, and therefore it is an unprecedented work.

[0016] Since there are no toothpastes containing the three medicinal plants mentioned above together, this work was prepared in the laboratory according to the international standard specifications approved for manufacturing toothpastes.

[0017] Fluoride toothpaste, lactate, and polyvinyl Methyle Thermaleic Anhydride are all additives to toothpaste to reduce cavities and improve enamel remineralization. Their danger lies in the fact that they are ultimately chemical substances, which may be the cause of the poisoning if there was an error in calculating their percentage, (Aldrin Joshua A, et al, 2020).

[0018] Perhaps it is important to note that chemicals, regardless of their concentration, accumulate in the human body and may therefore have negative repercussions over time. We can explain why our ancestors were healthier than our generations due to their total reliance on what nature produces.

[0019] The important substance found in the composition of Cloves is Eugenol, and this substance is used as a local anesthetic and also as a pain killer, especially in dentistry, therefore, Clove oil can be considered a very important substance in treating toothaches. It also works as an analgesic, antiseptic, and antibacterial, which makes it very important in the composition of pastes, mouth rinses, and local anesthetics used to treat oral ulcers and inflammations, (Dipesh Pramod Patil, et al, 2023).

[0020] We conclude from this study some important points:

[0021] Adding medicinal plants to toothpastes increases their effectiveness and quality.

[0022] Laboratory tests have shown the effectiveness of medicinal plants in inhibiting the growth of the most virulent types of bacteria found in the human mouth.

[0023] This experiment can be used to prepare mouthwash and shaving foam.Solution to Problem

[0024] In this work, three herbal plants were used with an extensive range of benefits and features that make them unique: Clove, Frankincense, and Caper.

[0025] Clove flowers were ground to obtain a very fine powder used for preparation an emulsion at a concentration of 20%, which left to cool and filtered, a sample sent to the laboratory, and the remaining was placed in a flask and sent to the factory to prepare toothpaste.

[0026] Frankincense is available in the form of hard granules that have been ground to turn into a very fine powder to prepare an emulsion at a concentration of 20% kept in a special flask and sent to the factory to be used in the preparation of toothpaste after taking a sample of it to be sent to the laboratory to conduct the sensitivity test.

[0027] Several stems were separated from the Caper shrub and the leaves were severed to be washed and cut to prepare an aqueous solution at a concentration of 10%, the solution is left to cool and then filtered and placed in a flask, it is transmitted to the factory to prepare the paste after a small sample of it was sent to the laboratory.

[0028] In the laboratory, Cloves, Frankincense emulsions, and Caper solution were collected with the "raw materials originally used in the preparation of toothpaste" to be deposited in the mixer and stirring under heat and pressure to produce toothpaste containing within it's composition herbal plants with benefits beyond the mouth to all parts of the human body.

[0029] Toothpastes can come in the form of gel, paste or powder, and although the ingredients vary slightly, all toothpastes contain the following ingredients in their composition:• Water by 20-40% .• Abrasive material at a rate of 50% and includes Aluminum hydroxide, Calcium Hydrogen Phosphates, Calcium Carbonate, Silica and Hydroxyapatite.Fluoride is usually 1450 ppm in the form of Sodium Fluoride, Stennis Fluoride .• Stannus Fluoride or Sodium Monofluorophosphate• Detergent usually used: sodium Lauryl Sulfate (SLS) at a concentration ranging between 0.5-2%• Antibacterial agents such as Triclosan or Zinc Chloride.• Flavors such as Spearmint• Remineralizers such as Hydroxyapatite Nanoparticles and Calcium Phosphate• Humectants such as Glycerol, Xylitol, Sorbitol, Polyethylene Glycol, and Propylene Glycol.• Antisensitivity agents such as Strontium Chloride, Potassium Nitrate, and Arginine• Anticalculus agents such as Sodium Polyphosphate and Zinc Citrate.

[0030] All pastes may share the same basic ingredients, but they are not all the same, as other ingredients may be added to obtain other benefits, (Perrotti, A. Piattelli, et al, 2017) and (American Dental Association, 2024).

[0031] Scientific name of Cloves, is S. aromaticum, it is rich with many phytochemicals such as Sesquiterpenes, Monoterpenes, Hydrocarbons, and Phenolic Compounds. Eugenyl Acetate, eugenol, and [3-caryophyllene are among the most important phytochemical compounds found in Clove oil, (El- Saber Batiha, et al 2020).

[0032] An infusion was prepared from the three plants: “Cloves, Frankincense, and Caper,” as follows:

[0033] In case of Cloves; their sticks were ground to turn into a very "fine powder", Figure No. 4a & b, used to prepare an infusion with a concentration of 20% (200 gm 1800 ml of water) by heating it to boiling point with water and leaving it to cool and filtered from the sediment, Figure No. 5a, a sample sent to the laboratory for the purpose of examination, Figure No. 6a.

[0034] The Frankincense granules, Figure No. 4c, were ground to become a very "fine powder", Figure No. 4d, and boiled water was added to it at a concentration of 20% (200 gm 1800 ml of water) and left for 10 hours, sufficient for their components to dissolve, producing a homogeneous emulsion, Figure No. 5b, with a sample sent to the laboratory for examination, Figure No. 6b.

[0035] In case of the Caper, it's leaves were extracted from the stems to be washed and cut, Figure No. 4e & f, then they were added to water at a concentration of 10% (100 gm 1900 ml of water) and boiled until the color of the water changed to become greenish, then it was filtered, producing a homogeneous solution No. 5c, with a sample sent to the laboratory for the purpose of examination, Figure No. 6c.

[0036] In the laboratory, Sensitivity Test disks were prepared by placing discs of paper in three colors: pink, which represents Cloves, white, which represents Frankincense, and light green, which represents Caper. These disks were placed in the infusions of Cloves, Frankincense, and the Caper solution for half an hour. They were then transferred to be distributed on dishes cultured with the most seven virulent and widespread germs present in the oral cavity; Streptococcus mutans, Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Klebsiella, spp Streptococcus pyogens, Pseudomonas aeruginosa.

[0037] Then the dishes were transferred to the incubator at a temperature of 37°C for 24 hours to determine the extent of the plant's ability to inhibit or stop their growth.

[0038] The flasks containing the Clove and Frankincense infusion and the Caper solution were sent to the factory to be mixed with the rest of the traditional ingredients used in preparing toothpaste, which are: a. Alpha aluminum hydroxide 57% is used as a mechanical cleaning agent "Friction Agent". b. Sorbitol 27% "Moisturizing and Emollient". c. Sodium Lauryl Sulfite 2.35% "detergent".d. Sodium Carboxymethyl Cellulose 0.65% "a binder for liquids and solids and also provides texture". e. Sodium Monofluorophosphate 0.85%" a caries-preventing agent". f. Sodium Monophosphate 0.3% "pH Stabilizer". g. Saccharin 0.2% "Sweetener". h. Titanium Dioxide 0.5% "Bleaching Agent". i. Irgasan 0.3% "Preservative". j. Cloves 20% 1% "Recognized before". k. Frankincense 20% 1% "Recognized before". l. Caper 10% 1 % "Recognized before". m. Flavoring Agents: Strawberry, Banana, Green Apple, Chocolate, and Cloves 0.5% "for adding the required flavor and taste". n. Food Coloring Agents 0.5%, then adding distilled water to the total weight of the mixture, i.e.100%.

[0039] The standard quantities of all the materials used in the mixture were weighed using a special scale for solids and a special scale for liquids, after weighing, the solids are gradually transferred to a special device followed by the liquids to mix them, the device moved slowly, then completely closed, and an attached device operated to evacuate it from the air.

[0040] The mixing process lasts for 45 minutes, the Flavorings, Medicinal Plants, and Colors added as a final stage, while mixing continues for another 20 minutes under heat and pressure. After the mixing is complete, the paste is examined for homogeneity, appearance, and air bubbles, if it matches the normative slandered , a sample is taken to assesses the Specific Weight and another for Bacteriological and Fungal Examination by culturing it in incubators designated for this purpose.

[0041] Bacterial and Fungi Incubators

[0042] In addition to checking the acidity of the compound using a pH Meter, these tests require at least 24 hours during which the paste is transferred to aspecial tank until the results matched. For further ensuring the safety and cleanliness of the product, all supplies are sterilized using an Ultraviolet Sterilization Hood.

[0043] The process completed by filling the prepared paste into tubes through a specialized system that contains sensors installed on them.

[0044] All equipment and product conveying lines are made of Nutritional Stainless Steel. Figure 7 shows the equipments used in preparing toothpaste.

[0045] Results

[0046] The results of the sensitivity test conducted on 7 types of bacteria considered the most virulent in the oral cavity, including the gums, lips, teeth, and tongue, showed that the three plants were excellent efficacy in inhibiting all bacterial types, which was clearly evident through the halos of inhibition surrounding the discs of each plant type, Figure 8.

[0047] After completing the preparation process, the product was filled into special bottles that hold 30 ml / 75 g each. The bottles are 10 cm long, 3 cm in diameter and 10 cm in circumference. Figure 9 shows the toothpaste with the flavors of “banana, strawberry, clove, chocolate / caramel and green apple.”

[0048] These bottles also undergo a very rigorous laboratory testing process to ensure they are free of any source of contamination and are suitable for this purpose.Brief Description of Drawings

[0049] Figure; 1 , shows the Clove tree, it's leaves, and flowers.

[0050] Figure; 2, shows the Frankincense tree, it's leaves and flowers.

[0051] Figure; 3, shows the Caper tree, it's leaves and flowers.

[0052] Figure 4, shows Cloves before (a) and after grinding (b), Frankincense before (c) and after grinding (d), and Caper before (e) and after removing the leaves from the stems and cutting them (f).

[0053] Figure; 5, shows the infusion of Clove a and Frankincense b at a concentration of 20%, and Caper c at a concentration of 10%.

[0054] Figure; 6, shows samples of Clove a , Frankincense b, and Caper c sent to the laboratory for sensitivity testing against harmful oral bacteria.

[0055] Figure; 7, shows the devices and equipment used in the study.

[0056] Figure; 8, shows the results of the sensitivity test for the most virulent oral bacteria. The inhibition halos surrounding the clove tablets (pink), gum (white), and saffron (green) are shown.

[0057] Figure; 9, shows the toothpaste prepared in different flavors (banana, strawberry, clove, chocolate / caramel, and green apple).Examples

[0058] In the production stage: two types of toothpaste were prepared "a type for children with banana and strawberry flavors" and a type for adults with flavors of " chocolate, clove and green apple" and in different colors, to suit the taste of the consumers.

[0059] As for the samples sent to the laboratory, sensitivity test disks have been prepared, including "pink for Cloves, white for Frankincense, while the green color represents Caper" by soaking the disks in the emulsions and solution "each separately" for half an hour and then transferring them to plates of sensitivity test.

[0060] Seven species of the most virulent bacteria commonly found in the oral cavity have been cultured to determine the ability of herbal plants to inhibit their growth: Streptococcus mutans, Staphylococcus aureus, Escherichia coli, Staphylococcus, Klebsiella, spp. epidermidis, Streptococcus pyogens, Pseudomonas aeruginosa.

[0061] The laboratory results indicated that the three plants have a unique ability to inhibit the growth of all types of microorganisms that were clearly shown through the inhibition zones that surrounded the disks for all types of bacteria.Industrial Applicability

[0062] Preparing a toothpaste that contains in it's composition herbal plants with good medicinal value, such as Clove, Frankincense, and Caper. In general, these materials combination have a very significant impact on thesafety of the teeth and gums in particular and the oral cavity in general. It is possible that this preparation can be produced industrially as a modular production to be accessible to the consumer at a time; the world is witnessing a great trend towards the use of medicinal plants.

[0063] There are a very large number of toothpastes that can be classified in different ways, they may be classified depending on the need for them into: a. Prevention of dental caries b. Anti - Plaques c. Anti-tartar d. Good breath e. Whitening the teeth f. Sensitive teeth and gingiva g. Antibacterial h. There are natural, non-chemical toothpastes (Helvident, Cliniques Dentaries, 2022).

[0064] In United States, toothpastes are classified differently: Fluoride Toothpastes, Whitening Toothpastes, Children's Toothpastes, Natural Toothpastes, and toothpastes for people with sensitive gums and teeth. Choosing the right toothpaste depends on several factors, most notably oral health needs, personal preferences, age, and budget.

[0065] Regarding oral health needs: Are there any specific dental concerns, such as cavities, tartar buildup, or sensitivity?

[0066] Regarding personal preferences: Someone may prefer a certain flavor or texture of toothpaste. Are there allergies to any of the toothpaste ingredients?

[0067] Age is also important, as children under six should use toothpaste containing a low concentration of fluoride, while adults and older children can use regular fluoride toothpaste, toothpaste prices vary depending on the brand and type. (Freytag, 2023).

[0068] Most toothpaste companies are keen to add fluoride to their formula, as it is considered the most effective way to prevent caries, fluoride reduces enamel demineralization and promotes remineralization, there are many preparations that use fluoride in their formula in addition to toothpastes, such as varnish, gel, and mouth rinse.

[0069] In some countries, health systems resort to add fluoride to drinking water, salt, or even milk, however, this remains a double - edged sword, as excessive fluoride intake may cause poisoning and have a negative impact on their growth, especially in children, (Haiyang Sun, et al, 2020).

[0070] In the same context, increasing the percentage of fluoride in toothpaste may reduce the risk of cavities, but in return it may lead to poisoning, also, decreasing the percentage of fluoride may lead to an increased chance of tooth decay.Invention Advantages a. The medicinal plants, laboratory equipment, materials, and equipment used in the study were all locally available and inexpensive. b. The method of preparing toothpaste, available in various colors and flavors, is very easy and can be performed by any laboratory technician. c. The need for specialized equipment, such as pressure, heat, and grinding, was met in a factory affiliated with a "Public Sector Company", with which the collaboration occur to prepare the toothpastes. d. Two types of toothpaste were prepared: one for adults and the other for children, with flavors they like, encouraging them to brush their teeth at the specified times after meals.Reference

[0001] Perrotti , A. Piattelli , A. Quaranta , G. Gomez-Moreno , G. lezzi, (2017); Biocompatibility of dental biomaterials, Woodhead Publishing Series in Biomaterials, Chapter 1 , Pp: 1 - 7.

[0002] American Dental Association, (2024); Toothpaste, https: / / www.mouthhealthy.org / en / all-topics-a-z / toothpaste.

[0003] El-Saber Batiha, G.; Alkazmi, L.M.; Wasef, L.G.; Beshbishy, A.M.; Nadwa, E.H.; Rashwan, E.K. Syzygium aromaticum L. (Myrtaceae),(2020); Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities. Biomolecules 2020, 10, 202. https: / / doi.Org / 10.3390 / biom10020202.

[0004] Sachan, A. K., Kumar, S., Kumari, K., and Singh, D., (2018). Medicinal Uses of Spices Used in Our Traditional Culture: Worldwide. J. Med. Plants Stud. 6 (3), 116-122.

[0005] Gloria Aderonke Otunola, (2021 ); Culinary Spices in Food and Medicine: An Overview of Syzygium aromaticum , Front. Pharmacol., 17 January 2022, Sec. Ethnopharmacology Volume 12 - 2021 | https: / / d0i.0rg / l 0.3389 / fphar.2021 .793200.

[0006] Flora Fauna Web. ,(2024); All Rights Reserved, Last updated on 16 July 2024, https: / / www.nparks.gov.sg / florafaunaweb / flora / 3 / 1 / 3154.

[0007] Hidayat Hussaina, Luay Rashanb, Uzma Hassanc, Muzaffar Abbasd, Faruck L. Hakkime and Ivan R. Green, (2022); Frankincense diterpenes as a bio-source for drug discovery. Expert Opinion on Drug Discovery 2022, Vol..17, NO. 5, 513-529https: / / doi.org / 10.1080 / 17460441 .2022.2044782

[0008] Ahmed Al-Harrasi , Najeeb Ur Rehman, Abdul Latif Khan, Muhammed Al-Broumi, Issa Al-Amri, Javid Hussain, Hidayat Hussain, Rene Csuk, (2018); Chemical, molecular and structural studies of Boswellia species: [3-Boswellic Aldehyde and 3-epi-11 |3-Dihydroxy BA as precursors in biosynthesis of boswellic acids, PLoS ONE 13(6): e0198666. https: / / d0i.0rg / l 0.1371 / journal.pone.0198666.

[0009] Shaden A.M. Khalifa , Safaa M. Kotb , Shaden H. El-Seedi , Lutfun Nahar , Satyajit D. Sarker , Zhiming Guo , Xiaobo Zou , Syed G. Musharraf , Amir Reza Jassbi , Ming Du , Hesham R. El-Seedi, (2023); Frankincense of Boswellia sacra: Traditional and modern applied uses, pharmacologicalactivities, and clinical trials, Volume 203, 1 November 2023, 1 17106, Industerial Crops and Products.

[0010] Benzidane N, Aichour R, Guettaf S, Laadel N, Khennouf S, Baghiani A, Arrar L,(2020); Chemical investigation, the antibacterial andantifungal activity of different parts of Capparis spinosa extracts, Journal of Drug Delivery and Therapeutics. 2020; 10(5) : 1 18-125 http: / / dx.doi.Org / 10.22270 / jddt.v10i5.4388.

[0011] Noel Matthews, (2024); What are Capers? and everything you need to know, https: / / kapnosdc.com / what-are-capers

[0012] Annaz H, Sane Y, Bitchagno GTM, Ben Bakrim W, Drissi B, Mahdi I, El Bouhssini M, Sobeh M., (2022); Caper (Capparis spinosa L.): An Updated Review on Its Phytochemistry, Nutritional Value, Traditional Uses, and Therapeutic Potential. Front Pharmacol. 2022 Jul 22;13:878749. doi: 10.3389 / fphar.2022.878749. PMID: 35935860.

[0013] Oluwasina GO, Idris SO, Ogidi CO, Igbe FO.,(2023); Production of herbal toothpaste: Physical, organoleptic, phyto-compound, and antimicrobial properties. Heliyon. 2023 Feb 28;9(3):e13892. doi:10.1016 / j.heliyon.2023.e13892. PMID: 36923892; PMCID: PMC10009007.

[0014] Karadaglioglu, O. I.; Ulusoy, N.; Ba§er, K.H.C.; Hanoglu, A.; §ik, I. ,(2019);Antibacterial Activities of Herbal Toothpastes Combined with Essential Oils against Streptococcus mutans. Pathogens 2019, 8, 2

[0015] Demir S, Keskin G, Akai N, Zer Y., (2021 ); Antimicrobial effect of natural kinds of toothpaste on oral pathogenic bacteria. J Infect Dev Ctries. 2021 Oct 31 ;15(10):1436-1442. doi: 10.3855 / jidc.14966. PMID: 3478036

[0016] Helvident, Cliniques Dentaries, (2022); The different types of toothpaste for adults, https: / / helvident.ch / en /

[0017] Freytag, (2023); Types of Toothpaste and How to Choose One. https: / / www.walbridgedental.com / blog / types-of-toothpaste / .

[0018] Haiyang Sun, Feng Luo, and Qianbing Wan, (2020); The Application of Fluoride in Dental Caries. Dental Caries, Chapter 2, Pp: 3- 14, DOI:10.5772 / intechopen.91810.

[0019] Aldrin Joshua A, Keerthi Sasanka L, Gifrina Jayaraj, Dhanraj Ganapathy, (2020); Review on Caries Preventive Effect of Fluoride Toothpastes, Indian Journal of Forensic Medicine & Toxicology, October- December 2020, Vol. 14, No. 4.

[0020] Dipesh Pramod PatiH , Bhavesh Patil, Momin Abrarul Haque, Riya Patil, (2023); Profile of clove in dental products; A review, International Journal of Creative Research Thoughts IJCRT | Volume 11 , Issue 11 November 2023

Claims

Claims

1. A herbal toothpaste method comprising: a. Alpha aluminum hydroxide 57%; b. Sorbitol 27%; c. Sodium Lauryl Sulfite 2.35%; d. Sodium Carboxymethyl Cellulose 0.65%; e. Sodium Monofluorophosphate 0.85%; f. Sodium Monophosphate 0.3%; g. Saccharin 0.2%; h. Titanium Dioxide 0.5%; i. Irgasan 0.3%; j. Cloves 20% to 1%; k. Frankincense 20% to 1%; l. Caper 10% to 1%; m. Strawberry, Banana, Green Apple, Chocolate, and Cloves 0.5%; n. Food Coloring Agents 0.5%; o. Distilled water.

2. The herbal toothpaste according to claim 1 , wherein the solids are gradually transferred to a special device followed by the liquids to mix them, the device moved slowly, then completely closed, and an attached device operated to evacuate it from the air.

3. The herbal toothpaste according to claim 1 and 2, wherein the mixing process lasts for 45 minutes, the Flavorings, Medicinal Plants, and Colors added as a final stage, while mixing continues for another 20 minutes under heat and pressure.

Images