Human breast cancer MDA-mb-231 cell proliferation inhibitor

WO2025187114A8PCT designated stage Publication Date: 2025-10-02WATANABE OYSTER LAB
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Patent Information

Application Number
PCT/JP2024/037697
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-03-05
Filing Date
2024-10-23
Publication Date
2025-10-02

AI Technical Summary

Technical Problem

Current treatments for bone metastasis in breast cancer, such as bisphosphonates and chemotherapy, are associated with severe side effects, and there is a need for more effective compounds with fewer adverse effects on normal tissues.

Method used

The use of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), a phenolic antioxidant, to inhibit the proliferation and metastatic activity of human breast cancer MDA-MB-231 cells by blocking various signaling pathways and regulating protein levels, thereby reducing TNF-α production and promoting apoptotic cell death.

Benefits of technology

DHMBA effectively inhibits the growth and metastasis of breast cancer cells, reduces bone microenvironment impairment, and minimizes side effects, providing a promising therapeutic strategy for breast cancer treatment.

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Abstract

[Problem] The present invention provides an inhibitor such as an MDA-MB-231 cell proliferation inhibitor containing DHMBA as an active ingredient, the inhibitor affecting the proliferation, metastatic activity, and bone microenvironment of MDA-MB-231 cells in vitro, and making it possible to provide a useful therapeutic strategy for human breast cancer. [Solution] The present invention is characterized by having the effect of inhibiting the proliferation of human breast cancer MDA-MB-231 cells containing 3,5-dihydroxy-4-methoxybenzyl alcohol as an active ingredient.
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