Composition for strengthening skin barrier

Abstract

The present invention relates to a composition for strengthening the skin barrier comprising an avenanthramide. The present invention improves skin turnover, skin aging alleviation, and moisturizing effects by using an avenanthramide together with serine or betaine and thus can achieve synergistic effects in strengthening and improving the skin barrier.

Description

Composition for strengthening the skin barrier

[0001] The present invention relates to a composition for strengthening the skin barrier comprising avenanthramide.

[0002] The skin serves as the body's primary protective barrier, conserving moisture and protecting it from the external environment. It is largely composed of the epidermis, dermis, and subcutaneous fat. The epidermis, derived from the ectoderm, is divided into an inner layer, the malpighian layer, composed of living cells, and an outer layer, the stratum corneum, composed of dead, flat, and dry cells that are anucleate. The epidermis maintains homeostasis through the continuous process of epidermal cell formation, differentiation, and shedding, and plays a crucial role in maintaining moisture.

[0003] The main constituent cells of the epidermis are divided into four layers: the stratum corneum, the granular layer, the spinous layer, and the basal layer, depending on the degree of differentiation of the keratinocytes. Gene expression varies depending on each layer. The stratum corneum, which constitutes the epidermis and is located at the outermost layer, is composed of 50% keratin, 20% lipid, 23% aqueous solution, and 7% moisture, and its thickness varies depending on its moisture content. The stratum corneum has the ability to absorb and retain moisture, keeping the skin supple and smooth. It must contain about 30% moisture to maintain a healthy skin condition. If the moisture content of the stratum corneum falls below 10%, the skin barrier becomes abnormal, the moisturizing ability of the stratum corneum decreases, and the skin becomes dry. In addition, it is known that when the moisture content of the stratum corneum is below 10%, the skin becomes dry and becomes the cause of skin trouble. The moisture content within the stratum corneum, which is created through regular keratinization, always remains at 10 to 20%. This is due to the sebum film, which is a mixture of sweat and sebum, protecting the skin from the outside and preventing moisture from evaporating from the stratum corneum. Beneath the stratum corneum, there are two major barriers of the epidermis, called tight junctions. They function as a secondary barrier of the epidermis by strengthening the bonds between cells and playing a role in regulating the penetration of substances. The skin acts as a primary protective barrier to preserve moisture in the body and protect it from the external environment. However, its function can be impaired and it can become dry due to various physical and chemical stimuli, such as a dry external environment, excessive use of cleansers, a decrease in the secretion of various hormones that regulate metabolism, and exposure to ultraviolet rays.In addition, due to various reasons such as artificial temperature control of heating and cooling due to recent environmental changes or changes in lifestyle patterns, various stresses in social life and skin stress due to environmental pollution, frequent washing due to makeup habits, and natural skin aging due to aging, the moisture in the stratum corneum decreases, causing the skin to become dry, the surface to become rough, and the skin to look dull and lack moisture, so the need for compositions for strengthening the skin barrier or moisturizing the skin is increasing.

[0004] Meanwhile, oatmeal is a grain made by removing the husk from oats and processing them. It can be categorized into rolled oats, cut oats, and ground oats. Oatmeal contains avenanthramides, vitamins, and minerals, known to have astringent effects on the skin and increase elasticity. It is known to be used in products for moisturizing and treating atopic dermatitis. However, research on the fundamental skin barrier improvement effects of oatmeal-derived ingredients remains limited.

[0005] Under the above background, the inventors of the present invention have conducted extensive research efforts to improve the fundamental efficacy of the skin barrier, and have thus completed the present invention by confirming that the skin barrier is improved when avenanthramide, a key component of oatmeal, is used together with serine or betaine.

[0006] Accordingly, the object of the present invention is to provide avenanthramide; and

[0007] A composition for strengthening a skin barrier is provided, comprising at least one selected from the group consisting of serine and betaine.

[0008] Another object of the present invention is to provide a method for treating a patient comprising: providing a method ...

[0009] Provided is a skin barrier strengthening agent comprising at least one selected from the group consisting of serine and betaine.

[0010] Another object of the present invention is to provide a composition comprising: avenanthramide; and

[0011] A method for strengthening a skin barrier is provided, comprising a step of applying to the skin a composition for strengthening a skin barrier, the composition comprising at least one selected from the group consisting of serine and betaine.

[0012] One aspect of the present invention comprises: Avenanthramide; and

[0013] A composition for strengthening a skin barrier, comprising at least one selected from the group consisting of serine and betaine.

[0014] Hereinafter, the configuration of the present invention will be described in detail.

[0015] The term "avenanthramide" in the present invention refers to avenanthramide, which is well known as an active ingredient of the phenolic alkaloid group mainly contained in oats, and is also contained to some extent in cabbage, butterflies, and spore-infected carnations. Avenanthramide can exhibit anti-inflammatory, antioxidant, anti-itching, anti-skin irritation, and anti-arteriosclerotic effects.

[0016] The term "serine" in the present invention refers to a non-polar amino acid that plays an essential role in protein synthesis, regulation, and degradation in the human body. Serine forms part of the active site in enzymes and regulatory proteins, which are important components of proteins. Serine also plays a crucial role in the biosynthesis of the essential amino acid methionine and is used in the production of indomethane blue and other therapeutic agents within the body. Serine helps maintain skin moisture and regenerate skin. Furthermore, serine promotes skin cell growth and plays a crucial role in protein synthesis, which is necessary for repairing skin damage.

[0017] In the present invention, the term "betaine" refers to a compound having the chemical formula C5H 11 NO2 refers to trimethylglycine (TMG), which is synthesized through the irreversible oxidation of choline in the mitochondria of the body. It is essential for the synthesis of methionine by transferring a methyl group attached to the nitrogen atom of glycine, so it is widely used as a methionine supplement, which is insufficient in the general diet. Additionally, betaine has the effect of reducing eye and skin irritation and has unique zwitterionic electromagnetic properties.

[0018] In the present invention, the avenanthramide may be at least one selected from the group consisting of avenanthramide A, avenanthramide B, avenanthramide C, and avenanthramide D, but is not limited thereto.

[0019] In the present invention, the avenanthramide may be dihydroavenanthramide D (Dihydroavenanthramide D, Hydroxyphenyl propamidobenzoic acid), but is not limited thereto.

[0020] In the present invention, dehydroavenanthramide D may have a structure of the following [chemical formula 1]:

[0021] [Chemical Formula 1]

[0022]

[0023] The term "skin" in the present invention refers to the tissue covering the body surface of an animal, and is a broad concept that includes not only tissue covering the body surface such as the face or body, but also the scalp and hair. Meanwhile, in the present specification, "skin" may include not only biological skin, but also artificial skin or a skin mimic that embodies the state of biological skin.

[0024] In the present invention, the term "skin barrier strengthening use" means strengthening the function of the stratum corneum of the epidermis as a barrier layer against the outside, such as preventing moisture leakage to the outside and controlling the entry and exit of substances from the outside. Strengthening the skin barrier may mean preventing a state in which the skin barrier function is reduced or damaged, or a state in which the skin barrier function is likely to be reduced or damaged.

[0025] In the present invention, strengthening the skin barrier may encompass improving the skin barrier. Improving the skin barrier may refer to, but is not limited to, any action that removes the skin barrier from a state of reduced or damaged function, a state at risk of damage, or a state requiring prevention. More specifically, improving the skin barrier may refer to increasing the expression level of tight junction proteins present in the epidermis, thereby strengthening the bonds between keratinocytes present in the epidermis, thereby enhancing the function of the epidermis as a secondary barrier, controlling the penetration of substances.

[0026] In the present invention, avenanthramide and serine may be included in a weight ratio of 1:1 to 1:40, but is not limited thereto.

[0027] In the present invention, avenanthramide and betaine may be included in a weight ratio of 1:1 to 1:40, but is not limited thereto.

[0028] In the present invention, avenanthramide, serine and betaine may be included in a weight ratio of 1:1:1 to 1:40:40, a weight ratio of 1:1:1 to 1:30:30, for example, a weight ratio of 1:20:20, but is not limited thereto.

[0029] In the present invention, the composition for strengthening the skin barrier may be a cosmetic composition for strengthening the skin barrier.

[0030] In the present invention, the composition for strengthening the skin barrier may have a formulation selected from the group consisting of a solution, an external ointment, a cream, a foam, a nourishing toner, an emollient toner, a pack, an emollient, a makeup base, an essence, a liquid cleanser, a bath agent, a sunscreen cream, a sun oil, a suspension, an emulsion, a paste, a gel, a lotion, a powder, a soap, a surfactant-containing cleanser, an oil, a powder foundation, an emulsion foundation, a wax foundation, a patch, and a spray, but is not limited thereto.

[0031] In addition, the composition for strengthening the skin barrier of the present invention may additionally include one or more cosmetically acceptable carriers that are incorporated into general skin cosmetics, and may appropriately incorporate conventional ingredients such as oil, water, surfactants, moisturizers, lower alcohols, thickeners, chelating agents, pigments, preservatives, fragrances, etc., but is not limited thereto. The cosmetically acceptable carriers included in the composition of the present invention vary depending on the formulation.

[0032] When the formulation of the present invention is an ointment, paste, cream, or gel, animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, etc. may be used as carrier components, but are not limited thereto. These may be used alone or in combination of two or more.

[0033] When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, etc. can be used as carrier components, and especially in the case of a spray, a propellant such as chlorofluorohydrocarbon, propane / butane, or dimethyl ether can be additionally included, but is not limited thereto. These can be used alone or in combination of two or more.

[0034] When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizer or an emulsifier may be used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3-butyl glycol oil, etc. may be used, and in particular, cottonseed oil, peanut oil, corn germ oil, olive oil, castor oil and sesame oil, glycerol fatty acid ester, polyethylene glycol or fatty acid ester of sorbitan may be used, but is not limited thereto. These may be used alone or in a mixture of two or more.

[0035] When the formulation of the present invention is a suspension, liquid diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth may be used as carrier components, but are not limited thereto. These may be used alone or in combination of two or more.

[0036] When the formulation of the present invention is soap, alkali metal salts of fatty acids, fatty acid hemiester salts, fatty acid protein hydrolysates, isethionates, lanolin derivatives, fatty alcohols, vegetable oils, glycerol, sugars, etc. may be used as carrier components, but are not limited thereto. These may be used alone or in combination of two or more.

[0037] The composition of the present invention may include a cosmetically acceptable salt of an avenanthramide. As used herein, the term "cosmetically acceptable salt" includes a salt derived from a cosmetically acceptable inorganic acid, organic acid, or base. Furthermore, the term "pharmaceutically acceptable salt" includes a salt derived from a pharmaceutically acceptable inorganic acid, organic acid, or base, and the term "foodstuff-acceptable salt" includes a salt derived from a foodstuff-acceptable organic acid, inorganic acid, or base.

[0038] Another aspect of the present invention comprises: Avenanthramide; and

[0039] It relates to a use for strengthening the skin barrier, comprising at least one selected from the group consisting of serine and betaine.

[0040] Another aspect of the present invention comprises: Avenanthramide; and

[0041] A method for strengthening a skin barrier, comprising a step of applying to the skin a composition for strengthening a skin barrier, the composition comprising at least one selected from the group consisting of serine and betaine.

[0042] The present invention relates to a composition for strengthening the skin barrier, comprising avenanthramide. The present invention uses avenanthramide in combination with serine or betaine to enhance skin turnover, improve skin aging, and moisturize, thereby achieving a synergistic effect of strengthening and improving the skin barrier.

[0043] The advantages and features of the present invention, and the methods for achieving them, will become clearer with reference to the embodiments described in detail below. However, the present invention is not limited to the embodiments disclosed below, but may be implemented in various different forms. These embodiments are provided only to ensure that the disclosure of the present invention is complete and to fully inform those skilled in the art of the scope of the invention, and the present invention is defined only by the scope of the claims.

[0044]

[0045] Manufacturing Example 1. Manufacturing of a cosmetic composition according to a combination of oatmeal-containing ingredients.

[0046] Each cosmetic composition was prepared according to the combination of the active ingredients of oatmeal. Dihydroavenanthramide D (Hydroxyphenyl propamidobenzoic acid), one of the synthetic analogues of avenanthramide, was used. Dihydroavenanthramide D was used in a concentration of 5% in SymCalmin® (pentylene glycol, butylene glycol, hydroxyphenyl propamidobenzoic acid, Symrise, Germany). Serine (Serine, Activon) was used for serine, and AMINOCOAT (NATURAL EXTRACT BP20) (Betaine, ASAHI KASEI CHEMICALS CORPORATION) was used for betaine.

[0047] (Unit: ppm) Dehydroavenanthramide D-serine betaine ratio control group----single experimental group 150---experimental group 2-50--experimental group 3--50-2combined experimental group 45050--experimental group 5-5050-experimental group 650-50-3combined experimental group 75050501:1:1experimental group 810050502:1:1experimental group 950100501:2:1experimental group 10255005001:20:20

[0048]

[0049] Example 1. Evaluation of the expression level of tight junction-related proteins

[0050] Each cosmetic composition prepared in Example 1 was treated on HaCaT cells (keratinocytes) to evaluate the expression of tight junction component proteins.

[0051] Dehydroavenanthramide D-serine betaine ZO1 Control group---1.00 Experimental group 150 ppm--1.09 Experimental group 2-50 ppm-0.94 Experimental group 3--50 ppm 1.05 Experimental group 450 ppm 50 ppm-1.16 Experimental group 5-50 ppm 50 ppm 1.12 Experimental group 650 ppm-50 ppm 1.10 Experimental group 750 ppm 50 ppm 50 ppm 1.17 Experimental group 8100 ppm 50 ppm 50 ppm 1.20 Experimental group 950 ppm 100 ppm 50 ppm 1.23 Experimental group 1025 ppm 500 ppm 500 ppm 1.32

[0052]

[0053] The experimental results showed that when two components were combined, the expression of tight junction component proteins increased compared to when each component was treated alone. In addition, when all three components, dihydroavenanthramide D, serine, and betaine, were mixed and treated, the expression of tight junction component proteins increased compared to when each component was treated alone or in combination with only two components.

Claims

1. Avenanthramide; and A composition for strengthening the skin barrier, comprising at least one selected from the group consisting of serine and betaine.

2. In paragraph 1, A composition for strengthening the skin barrier, wherein the above avenanthramide is at least one selected from the group consisting of avenanthramide A, avenanthramide B, avenanthramide C, and avenanthramide D.

3. In paragraph 2, A composition for strengthening the skin barrier, wherein the above avenanthramide D is dihydroavenanthramide D (Dihydroavenanthramide D, Hydroxyphenyl propamidobenzoic acid).

4. In paragraph 1, A composition for strengthening the skin barrier, wherein the above avenanthramide and serine are included in a weight ratio of 1:1 to 1:

40.

5. In paragraph 1, A composition for strengthening the skin barrier, wherein the above avenanthramide and betaine are included in a weight ratio of 1:1 to 1:

40.

6. In paragraph 1, A composition for strengthening the skin barrier, wherein the above avenanthramide, serine and betaine are included in a weight ratio of 1:1:1 to 1:40:

40.

7. In paragraph 1, The composition for strengthening the skin barrier has a formulation selected from the group consisting of a solution, an external ointment, a cream, a foam, a nourishing toner, an emollient toner, a pack, an emollient, a makeup base, an essence, a liquid cleanser, a bath agent, a sunscreen cream, a sun oil, a suspension, an emulsion, a paste, a gel, a lotion, a powder, a soap, a surfactant-containing cleansing, an oil, a powder foundation, an emulsion foundation, a wax foundation, a patch, and a spray.

8. Avenanthramide; and A skin barrier strengthening agent comprising at least one selected from the group consisting of serine and betaine.

9. Avenanthramide; and A method for strengthening a skin barrier, comprising the step of applying to the skin a composition for strengthening a skin barrier, the composition comprising at least one selected from the group consisting of serine and betaine.

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