Dry-powder inhaler

Abstract

The invention relates to a dry-powder inhaler comprising: a body (110); a mouthpiece (120); a chamber (111); and a reservoir (10) containing a dose of dry powder and having at least one lateral outlet orifice (11), the reservoir being arranged in the chamber, the diameter of the reservoir being less than the diameter of the chamber, such that the reservoir can move in the chamber; the body having tangential channels (115a-115c) suitable for bringing a flow of inhalation air tangentially into the chamber, thereby causing the reservoir to move orbitally in the chamber during inhalation, the reservoir having at least one internal profile (17a, 17b) for guiding and / or dispersing the powder on expulsion by the flow of inhalation air.

Description

Dry powder inhaler

[0001] The present invention relates to a dry powder inhaler.

[0002] Powder inhalers are well known in the state of the art. There are different types.

[0003] A first type of multi-dose inhaler contains a reservoir receiving a multitude of doses of powder, the inhaler being provided with dosing means allowing each actuation to separate a dose of this powder from the reservoir to bring it into an expulsion duct in order to be distributed to the user. These devices require complex and therefore expensive dosing means, and the accuracy and reproducibility of the dosage are not guaranteed. In addition, there are risks of contamination of the powder placed in the reservoir as the inhaler is used.

[0004] Another type of multi-dose inhaler consists of providing several individual reservoirs, each containing a dose of powder, and then opening one of these reservoirs each time the inhaler is actuation. This implementation ensures a better seal for the powder, since each dose of powder is only exposed to the atmosphere when it is expelled. To produce these sets of individual reservoirs, various variants have already been proposed, such as strips or discs of blisters. Regarding the opening of the individual reservoirs, it has been proposed to peel or unstick the closing layer of the blisters. This has the disadvantage of difficult control of the forces to be applied to ensure complete opening without risking opening the next reservoir, particularly if the opening means must be activated by inhalation.Another solution is to pierce the closing membrane of a blister pack each time it is actuation, which requires complex and therefore expensive drilling methods.

[0005] The multi-dose inhalers described above also have the problem of not ensuring optimal delivery efficiency, with a significant portion of the dose actually entering the user's lungs to have a beneficial therapeutic effect.

[0006] To create less complex and therefore less expensive devices, single-dose inhalers have been proposed, comprising a single individual reservoir, such as a blister or capsule, which is loaded into the inhaler just before use. The advantage of these single-dose devices is that it is not necessary to store all the doses inside the device, so that it can be smaller. On the other hand, use is more complicated for the user, since they are required to load a blister or capsule into the inhaler before each use. In addition, other disadvantages specific to these single-dose inhalers exist. Thus, a blister or capsule does not allow the distribution of large doses, typically greater than 100 mg.In addition, opening, particularly of capsules or blisters that need to be pierced, requires the use of complex piercing methods, as well as a risk of residue from the pierced membrane in the dispensed powder. Furthermore, the emptying performance of the reservoir is not always optimal, as some of the powder may remain inside the reservoir during inhalation.

[0007] In an attempt to overcome these drawbacks, document WO9826828 proposed a single-dose inhaler comprising a cylindrical reservoir with a lateral opening, arranged in a cylindrical chamber of larger diameter, so that during inhalation, the reservoir moves in the chamber in an orbital movement, which causes the expulsion of the powder. This implementation effectively improves the efficiency of distribution, with substantially complete emptying of the reservoir and a larger portion of the dose actually entering the lungs. However, a drawback of this device is that the size of the reservoir must be well adapted to that of the chamber to ensure good orbital movement.However, unless the inhaler is modified, which would be very expensive, this does not allow the powder dose to be easily varied, although it may be desirable to be able to use the same inhaler with reservoirs containing different dosages. Another disadvantage of this type of device, particularly when the single-dose reservoir contains a large quantity of powder, concerns the risk of powder agglomerates forming in the reservoir, which can negatively impact the distribution of the powder during inhalation.

[0008] Documents WO02085281A1, WO03075988A1, WO2009121020A1, WO2013008037A1, WO2008001132A1, WO03051439, WO2024038237 and WO2024038234 describe other devices of the state of the art.

[0009] The present invention aims to provide a powder inhaler which does not reproduce the aforementioned drawbacks.

[0010] In particular, the present invention aims to provide such an inhaler which improves the delivery efficiency, by allowing the delivery of almost all of the powder contained in the reservoir and by increasing the portion of the dose which will reach the user's lungs.

[0011] The present invention also aims to provide such an inhaler which improves the deagglomeration and / or expulsion of the powder at the time of its distribution.

[0012] The present invention also aims to provide such an inhaler which improves the movement of the reservoir in the chamber upon actuation.

[0013] The present invention also aims to provide such an inhaler which reduces the complexity of use for the user and which guarantees better safety of use.

[0014] The present invention also aims to provide such an inhaler which is simple and inexpensive to manufacture and assemble.

[0015] The present invention therefore relates to a dry powder inhaler comprising:- a body and a mouthpiece provided with a dispensing orifice through which the user inhales,- a chamber,- a reservoir containing a dose of dry powder to be inhaled and comprising at least one lateral outlet orifice, said reservoir comprising an upper wall, a lower wall and an approximately cylindrical lateral wall connecting said lower and upper walls, said lateral outlet orifice being made in said lateral wall, said reservoir being, during inhalation, arranged in said chamber, the diameter of said reservoir being less than the diameter of said chamber, so that, during inhalation, said reservoir moves in said chamber, said body comprising tangential channels adapted to bring a flow of inhalation air tangentially into said chamber,which during inhalation generates an orbital movement of said reservoir in said chamber during inhalation, said reservoir comprising at least one internal profile for guiding and / or deagglomerating the powder at the time of its expulsion by said inhalation air flow, each internal profile comprising a plurality of ribs extending over at least one internal wall of said reservoir, being axially projecting, said ribs being arranged at a distance from said side wall, leaving a space between said side wall and said ribs.,

[0016] Advantageously, said reservoir is formed of an upper reservoir part and a lower reservoir part, which are assembled after filling with the dose of powder.

[0017] Advantageously, each part of the tank has its respective internal profile.

[0018] Advantageously, said lower part of the tank comprises said at least one lateral outlet orifice.

[0019] Advantageously, each internal profile comprises a plurality of radially extending ribs.

[0020] According to another advantageous variant, each internal profile comprises a plurality of ribs arranged around an axial center of said tank, in particular four ribs arranged in a diamond shape.

[0021] Advantageously, said reservoir comprises at least one external profile defining an inscribed volume forming an external volume of the reservoir greater than the internal volume of the reservoir which contains the powder.

[0022] Advantageously, each external profile comprises a plurality of ribs extending concentrically on an external wall of said tank.

[0023] Advantageously, said mouthpiece comprises a grid upstream of said dispensing orifice.

[0024] Advantageously, said chamber is arranged between an inhalation air inlet and said mouthpiece.

[0025] Advantageously, said reservoir contains a dose of powder greater than 50 mg, in particular greater than 100 mg.

[0026] Advantageously, the volume occupied by said reservoir in said chamber during inhalation is greater than 50% of the volume of said chamber.

[0027] Advantageously, the radial diameter of said reservoir is greater than its axial height.

[0028] Advantageously, said chamber is arranged in a loading member mounted to move, in particular pivot, on said body between an unloaded position, in which a reservoir can be arranged in said chamber, and a loaded position, in which said chamber and said reservoir are arranged inside said body of the inhaler.

[0029] Advantageously, said chamber is arranged in said body, said inhaler comprising an actuating member axially movable relative to said body to move said reservoir from an unloaded position to a loaded position.

[0030] Advantageously, said actuating member comprises at least one oblique groove receiving at least one respective lug formed on said body or on an element integral with said body, so that during its axial displacement, said actuating member rotates in said body.

[0031] These and other features and advantages of the present invention will become more apparent from the following detailed description, made with reference to the accompanying drawings, given by way of non-limiting examples, in which

[0032] is a schematic perspective view of an inhaler according to a first advantageous embodiment, before insertion of the reservoir into the inhaler,

[0033] is a view similar to that of the, after assembly of the tank but in the unloaded position,

[0034] is a view similar to that of the, in loaded position,

[0035] is a schematic cross-sectional view of an inhaler according to a second advantageous embodiment, in the loaded position,

[0036] is a schematic view from below of the tank in the chamber, in the loaded position,

[0037] is a schematic top view of the mouthpiece,

[0038] is a schematic perspective view of a tank according to a first advantageous embodiment variant, before closing the tank,

[0039] is a schematic cross-sectional view of the reservoir, after closing the reservoir,

[0040] is a schematic view similar to that of the, showing in perspective a tank according to a second advantageous embodiment variant, before closing the tank,

[0041] is a schematic cross-sectional view of the reservoir, after closing the reservoir, and

[0042] is a schematic view similar to that of the, showing in perspective a reservoir according to a third advantageous embodiment variant.

[0043] In the following description, the terms "upper", "lower" and "lateral" refer to the upright position of the device shown in the. The terms "axial" and "radial" refer to the longitudinal central axis A of the device.

[0044] Figures 1 to 3 describe a first advantageous embodiment.

[0045] In this first embodiment, the inhaler comprises a body 110 and a mouthpiece 120 provided with a dispensing orifice 121 through which the user inhales. A loading member 130 containing a chamber 111 is movably mounted, advantageously pivotally, on the body 110, between an unloaded position and a loaded position. In the unloaded position, a reservoir 10 can be disposed in the chamber 111, and in the loaded position, shown in the, the chamber 111 and the reservoir 10 are inside the body 110 of the inhaler.

[0046] Advantageously, as visible in the, the mouthpiece 120 comprises a grid 125 upstream of the dispensing orifice 121.

[0047] Preferably, the chamber 111 is disposed between an inhalation air inlet and said mouthpiece 120, such that when the user inhales through the mouthpiece 120, the airflow will pass through said chamber 111.

[0048] The inhaler comprises a reservoir 10 containing a dose of dry powder to be inhaled and comprising at least one lateral outlet orifice 11. The reservoir 10 comprises an upper wall 12a, a lower wall 12b and an approximately cylindrical lateral wall 13 connecting said lower and upper walls, the lateral outlet orifice 11 being made in this lateral wall 13.

[0049] The diameter of the reservoir 10 is smaller than the diameter of said chamber 111, so that during inhalation, the reservoir 10 can move in the chamber 111. Tangential channels 115a, 115b, 115c bring said inhalation air flow tangentially into the chamber 111, which will cause an orbital movement of the reservoir 10 in the chamber 111, the reservoir 10 rotating on itself while rotating around the periphery of the chamber 111 along the side wall thereof. This movement will allow the expulsion of the powder contained in the reservoir 10, which is carried by the inhalation air flow towards the mouthpiece and the dispensing orifice.

[0050] Advantageously, the reservoir 10 can contain a dose of powder greater than 50 mg, in particular greater than 100 mg. Optionally, very large doses can be envisaged, in particular greater than 500 mg.

[0051] Advantageously, the volume occupied by the reservoir 10 in the chamber 111 during inhalation is greater than 50% of the volume of the chamber 111.

[0052] Advantageously, the radial diameter of the reservoir 10 is greater than its axial height.

[0053] Advantageously, the reservoir 10 is formed of an upper reservoir part 10a, comprising the upper wall 12a, and a lower reservoir part 10b, comprising the lower wall 12b, which are assembled after filling with the dose of powder. Advantageously, it is the lower reservoir part 10b which comprises the at least one lateral outlet orifice 11. Advantageously, each lateral outlet orifice 11 is arranged axially centered in the lateral wall 13.

[0054] Advantageously, the reservoir 10 is symmetrical, so that it can be inserted into the chamber 111 indifferently in both directions.

[0055] Describes a second advantageous embodiment.

[0056] In this second embodiment, the inhaler comprises a body 110 containing a chamber 111 and a mouthpiece 120 provided with a dispensing orifice 121 through which the user inhales.

[0057] Advantageously, the body 110 is formed of two body parts, an upper body part comprising the mouthpiece 120 and a lower body part comprising a cylindrical sleeve 112, the chamber 111 being defined by these two body parts fixed to each other.

[0058] The inhaler also comprises an actuating member 130 for moving said reservoir 10 from its unloaded position to its loaded position. This actuating member 130 is axially movable relative to the body 110 to push the reservoir 10 from its unloaded position to its loaded position.

[0059] Advantageously, the axial displacement of the actuating member 130 is carried out by a rotation of the actuating member 130 in the body 110, for example by means of lug(s) of the body 110 arranged in one or more oblique groove(s) 150 of the actuating member 130.

[0060] Advantageously, the reservoir 10 may comprise at least one external profile 15 defining an external volume of the reservoir greater than the internal volume of the reservoir which contains the powder. This implementation makes it possible to optimize the external dimension of the reservoir 10 with respect to the dimension of the chamber 111, in order to guarantee good orbital movement of the reservoir 10 during inhalation. At the same time, the internal volume of the reservoir can be modified, while always keeping the same external volume, which makes it possible to use reservoirs with different dosages of powder in the same inhaler.

[0061] Advantageously, each tank part 10a, 10b has its respective external profile 15a, 15b.

[0062] Advantageously, each external profile 15 comprises a plurality of ribs 16 extending concentrically on the external wall of the reservoir 10, as visible in the. An advantage of such an external profile is that concentric ribs do not disturb the orbital rotational movement of the reservoir in the chamber at the time of inhalation.

[0063] Alternatively, the ribs may be radial, as shown in Figures 1 and 2.

[0064] The number of ribs can be any, as long as they define an inscribed volume forming the external volume of the tank.

[0065] According to the invention, the reservoir 10 comprises at least one internal profile 17a, 17b for guiding and / or deagglomerating the powder at the time of its expulsion by said inhalation air flow.

[0066] Advantageously, each tank part 10a, 10b has its respective internal profile 17a, 17b.

[0067] Each internal profile 17a, 17b comprises a plurality of ribs 18a, 18b which extend on an internal wall of the tank 10 while being axially projecting, as visible in FIGS. 7 to 11. Thus, if the upper tank part 10a comprises an internal profile 17a, then the ribs 18a extend on the upper wall 12a, and if the lower tank part 10b comprises an internal profile 17b, then the ribs 18b extend on the lower wall 12b. Preferably, there are ribs 18a, 18b on both tank parts 10a, 10b.

[0068] According to the invention, said ribs 18a, 18b are arranged at a distance from the approximately cylindrical side wall 13 of the reservoir 10, leaving a space between said side wall 13 and said ribs 18a, 18b. This implementation ensures perfect circulation of the powder at the level of this side wall 13, thus optimizing its expulsion through the lateral outlet orifice 11.

[0069] In the embodiments of Figures 7 to 10, the ribs 18a, 18b are arranged radially.

[0070] In the embodiment of the, the ribs 18a, 18b are arranged around the axial center of the reservoir. Advantageously, there is a plurality of ribs separated from each other by spaces, for example four ribs 18b arranged in a diamond shape in the example of the. Alternatively, any number of ribs could be around the axial center of the reservoir, for example three ribs arranged in a triangle, or five ribs arranged in a pentagon. This implementation proves to be particularly advantageous in the context of an orbital movement.Indeed, with such an orbital movement, that is to say that the reservoir rotates both around its own central axis but also around the central axis of the chamber, there is no risk of powder stagnating in the center of the reservoir, and the presence of the transverse ribs between the center and the radially external edge makes it possible to achieve effective deagglomeration of the powder before its expulsion through the lateral outlet orifice 11.

[0071] Of course, the embodiment of the applies with or without external profiles, in particular as described with reference to figures 9 and 10.

[0072] The device of the invention is simple and effective. It consists of a small number of parts, it is therefore inexpensive to manufacture and assemble, and reliable to use. It allows optimal distribution of the powder through the orbital movement of the reservoir during actuation and thanks to the internal profiles 17a, 17b, while guaranteeing the integrity of the powder until its use.

[0073] It should be noted that the inhaler is refillable, by removing the empty tank and replacing it with a full tank.

[0074] Various modifications are also possible for a person skilled in the art without departing from the scope of the present invention as defined by the appended claims.

Claims

Dry powder inhaler comprising:- a body (110) and a mouthpiece (120) provided with a dispensing orifice (121) through which the user inhales,- a chamber (111),- a reservoir (10) containing a dose of dry powder to be inhaled and comprising at least one lateral outlet orifice (11), said reservoir (10) comprising an upper wall (12a), a lower wall (12b) and an approximately cylindrical lateral wall (13) connecting said lower and upper walls, said lateral outlet orifice (11) being made in said lateral wall (13), said reservoir (10) being, during inhalation, arranged in said chamber (111), the diameter of said reservoir (10) being less than the diameter of said chamber (111), so that, during inhalation, said reservoir (10) moves in said chamber (111), said body (110) comprising tangential channels (115a, 115b, 115c) adapted to bring a flow of inhalation air tangentially into said chamber (111),which during inhalation generates an orbital movement of said reservoir (10) in said chamber (111) during inhalation, characterized in that said reservoir (10) comprises at least one internal profile (17a, 17b) for guiding and / or deagglomerating the powder at the time of its expulsion by said inhalation air flow, each internal profile (17a, 17b) comprising a plurality of ribs (18a, 18b) extending over at least one internal wall of said reservoir (10), being axially projecting, said ribs (18a, 18b) being arranged at a distance from said side wall (13), leaving a space between said side wall (13) and said ribs (18a, 18b)., An inhaler according to claim 1, wherein said reservoir (10) is formed of an upper reservoir portion (10a) and a lower reservoir portion (10b), which are assembled after filling with the dose of powder. An inhaler according to claim 2, wherein each reservoir portion (10a, 10b) has its respective internal profile (17a, 17b). An inhaler according to claim 2 or 3, wherein said lower reservoir portion (10b) comprises said at least one lateral outlet orifice (11). An inhaler according to any preceding claim, wherein each internal profile (17a, 17b) comprises a plurality of radially extending ribs (18a, 18b). Inhaler according to any one of claims 1 to 4, in which each internal profile (17a, 17b) comprises a plurality of ribs (18a, 18b) arranged around an axial center of said reservoir (10), in particular four ribs arranged in a diamond shape. Inhaler according to any one of the preceding claims, wherein said reservoir (10) comprises at least one external profile (15) defining an inscribed volume forming an external volume of the reservoir greater than the internal volume of the reservoir which contains the powder. An inhaler according to claim 7, wherein each outer profile (15) comprises a plurality of ribs (16) extending concentrically on an outer wall of said reservoir (10). An inhaler according to any preceding claim, wherein said mouthpiece (120) comprises a grid (125) upstream of said dispensing orifice (121). An inhaler according to any preceding claim, wherein said chamber (111) is disposed between an inhalation air inlet and said mouthpiece (120). Inhaler according to any one of the preceding claims, wherein said reservoir (10) contains a dose of powder greater than 50 mg, in particular greater than 100 mg. An inhaler according to any preceding claim, wherein the volume occupied by said reservoir (10) in said chamber (111) during inhalation is greater than 50% of the volume of said chamber (111). Inhaler according to any one of the preceding claims, wherein the radial diameter of said reservoir (10) is greater than its axial height. Inhaler according to any one of the preceding claims, wherein said chamber (111) is arranged in a loading member (130) mounted movable, in particular pivotable, on said body (110) between an unloaded position, in which a reservoir (10) can be arranged in said chamber (111), and a loaded position, in which said chamber (111) and said reservoir (10) are arranged inside said body (110) of the inhaler. An inhaler according to any one of claims 1 to 13, wherein said chamber (111) is disposed in said body (110), said inhaler comprising an actuating member (130) axially movable relative to said body (110) for moving said reservoir (10) from an unloaded position to a loaded position. Inhaler according to claim 15, wherein said actuating member (130) comprises at least one oblique groove (150) receiving at least one respective lug formed on said body (110) or on an element integral with said body (110), so that during its axial displacement, said actuating member (130) performs a rotation in said body (110).* * *

Images