Molecules having pesticidal utility and processes related thereto

Abstract

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides.

Description

[0001] 212203-WO-SEC-1 Page 1 of 152 MOLECULES HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO 5 BACKGROUND This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, 10 molluscicides, and nematicides. “Many of the most dangerous human diseases are transmitted by insect vectors” (Rivero et al., Insect Control of Vector–Borne Diseases: When is Insect Resistance a Problem? Public Library of Science Pathogens, Vol.6, No.8, p.1–9, 2010). “Historically, malaria, dengue, yellow fever, plague, filariasis, louse–borne typhus, trypanosomiasis, leishmaniasis, and other 15 vector borne diseases were responsible for more human disease and death in the 17ththrough the early 20thcenturies than all other causes combined” (Gubler, D., Resurgent Vector–Borne Diseases as a Global Health Problem, Emerging Infectious Diseases, Vol.4, No.3, p.442–450, 1998). Vector–borne diseases are responsible for about 17% of global parasitic and infectious diseases. Malaria alone causes over 800,000 deaths a year, 85% of which occur in children under 20 five years of age. Each year there are approximately 50 to 100 million cases of dengue fever. A further 250,000 to 500,000 cases of dengue hemorrhagic fever occur each year (Matthews., Integrated Vector Management: Controlling Vectors of Malaria and Other Insect Vector Borne Diseases, Ch.1, p.1, 2011). Vector control plays a critical role in the prevention and control of infectious diseases. However, insecticide resistance, including resistance to multiple insecticides, 25 has arisen in all insect species that are major vectors of human diseases (Rivero et al.). Recently, more than 550 arthropod species have developed resistance to at least one pesticide (Whalon et al. Analysis of Global Pesticide Resistance in Arthropods, Global Pesticide Resistance in Arthropods, Ch.1, p.5–33, 2008). Furthermore, the cases of insect resistance continue to exceed by far the number of cases of herbicide and fungicide resistance (Sparks et al., IRAC: Mode of 30 action classification and insecticide resistance management, Pesticide Biochemistry and Physiology (2014) available online 4 December 2014). 212203-WO-SEC-1 Page 2 of 152 Each year, insects, plant pathogens, and weeds destroy more than 40% of all food production. This loss occurs despite the application of pesticides and the use of a wide array of non–chemical controls, such as crop rotations and biological controls. If just some of this food could be saved, it could be used to feed the more than three billion people in the world who are 5 malnourished (Pimental, D., Pest Control in World Agriculture Agricultural Sciences – Vol. II, 2009). Plant parasitic nematodes are among the most widespread pests and are frequently one of the most insidious and costly. It has been estimated that losses attributable to nematodes range from approximately 9% in developed countries to 15% in underdeveloped countries. However, in 10 the United States of America a survey of 35 States on various crops indicated nematode–derived losses of up to 25% (Nicol et al., Current Nematode Threats to World Agriculture, Genomic and Molecular Genetics of Plant – Nematode Interactions, p.21–43, 2011). It is noted that gastropods (slugs and snails) are pests of less economic importance than other arthropods or nematodes, but in certain places, they may reduce yields substantially, 15 severely affecting the quality of harvested products, as well as, transmitting human, animal, and plant diseases. While only a few dozen species of gastropods are serious regional pests, a handful of species are important pests on a worldwide scale. In particular, gastropods affect a wide variety of agricultural and horticultural crops, such as arable, pastoral, and fiber crops; vegetables; bush and tree fruits; herbs; and ornamentals (Speiser, B., Molluscicides, 20 Encyclopedia of Pest Management, Ch.219, p.506–508, 2002). Termites cause damage to all types of private and public structures, as well as to agricultural and forestry resources. In 2005, it was estimated that termites cause over US$50 billion in damage worldwide each year (Korb, J., Termites, Current Biology, Vol.17, No.23, 2007). 25 Consequently, for many reasons, including those mentioned above, there is an on–going need for the costly (estimated to be about US$286 million per pesticide in 2014), time– consuming (on average about 11.3 years per pesticide), and difficult, development of new pesticides (Phillips McDougall, The Cost of New Agrochemical Product Discovery, Development and Registration in 1995, 2000, 2005-8 and 2010-2014. R&D expenditure in 2014 30 and expectations for 2019, 2016). 212203-WO-SEC-1 Page 3 of 152 SUMMARY Disclosed herein is a molecule of Formula I: 5 Formula I wherein; A) X is selected from the group consisting of -H and (C1-C6) alkyl; B) R1is -H or -CH3; C) R2is -H or -F; 10 D) R3is selected from the group consisting of -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2- CH3, -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O-CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, -CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3; E) R4is selected from the group consisting of -H, -CH3and when R4is -O, a fused ring comprising the following structure: 212203-WO-SEC-1 Page 4 of 152 F) R5is selected from the group consisting of -CH3, -OCH3, -N(CH3)2, and a fused ring comprising the following structure when R4is -O: 5 G wherein A) R6is -H or -F; B) R7is selected from the group consisting of -Cl, -CF3, -OCF3, CN, -SF5, and -SCF3; and10 C) R8is -H or -F; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula I. Disclosed herein is also a molecule having Formula II: 212203-WO-SEC-1 Page 5 of 152 Formula II wherein, A) R1is -H or -CH3; 5 B) R2is H or F; C) X is selected from the group consisting of -H, -CH3, and -CH2CH3; F) R3 is -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2-CH3, -CH2-O-CH3, - CH(CH3)2, -CH2-O-CH2-CF2Cl, -OCH2CH2CF3,-CH2-O-CH2-CF2-CH3, and -CH2-O-CH2-CHCl2; G) R4is selected from the group consisting of -H, -CH3or when R7is O, a fused ring having the following 10 structure: H) R5is selected from the group consisting of -CH3, -N(CH3)2, -OCH3, and a fused ring having the following structure when R7is O: 212203-WO-SEC-1 Page 6 of 152 I) R6 is -F or -H; J) R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula II. 5 Disclosed herein is also a molecule having Formula III: Formula III wherein, A) R1-H or -CH3; 10 B) R2is -H or -F; C) R3is selected from the group consisting of -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O-CH2-CF2- CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, -CH2-O-CH3, - CH(CH3)2, and -CH2-CH2-CH3; 212203-WO-SEC-1 Page 7 of 152 B) R4is selected from the group consisting of -H, -CH3and when R2is -O, a fused ring comprising the following structure: ; C) R5is selected from the group consisting of -CH3, -OCH3, -N(CH3)2, and a fused ring comprising the 5 following structure when R2is -O: , where, 10 R6is H or F; R7is selected from the group consisting of -Cl, -CF3, -OCF3, CN, -SF5, and -SCF3; and R8is H or F; E) X is selected from the group consisting of -H, -CH3, and -CH2CH3;and 212203-WO-SEC-1 Page 8 of 152 resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula III. DEFINITIONS Examples provided herein are not exhaustive and should not be construed as limiting. It is understood that a substituent should comply with chemical bonding rules and steric 5 compatibility constraints in relation to the particular molecule to which it is attached. These definitions are only to be used for the purposes of this disclosure. The term “AIGA” means the following group of pesticides, each of which is considered an “active ingredient” (sometimes also referred to as an “active” or an “active compound”) - (3- ethoxypropyl)mercury bromide, (S)-afoxolaner, 1,2-dibromoethane, 1,2-dichloroethane, 1,2-10 dichloropropane, 1,3-D, 1,3-dichloropropene, 1-methylcyclopropene, 1-naphthol, 2- (octylthio)ethanol, 2,2,3-TPA, 2,3,3-TPA, 2,3,5-triiodobenzoic acid, 2,3,6-TBA, 2,4,5-T, 2,4,5- TB, 2,4,5-TP, 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 2,4-DES, 2,4-DP, 2,4-MCPA, 2,4-MCPB, 2,5- dichlorobenzoic acid, 24-epibrassinolide, 2iP, 2M-4C, 2M-4CM, 2-methoxyethylmercury chloride, 2-phenylphenol, 3,4-DA, 3,4-DB, 3,4-DP, 3,6-dichloropicolinic acid, 4-aminopyridine,15 4-CPA, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol, 8-hydroxyquinoline sulfate, 8- phenylmercurioxyquinoline, abamectin, abamectin-aminomethyl, abscisic acid, ACC, acephate, acequinocyl, acetamiprid, acethion, acetochlor, acetofenate, acetophos, acetoprole, acibenzolar, acifluorfen, aclonifen, ACN, acrep, acrinathrin, acrolein, acrylonitrile, acynonapyr, acypetacs, afidopyropen, afoxolaner, AITC, alachlor, alanap, alanycarb, albendazole, aldicarb, aldicarb 20 sulfone, aldimorph, aldoxycarb, aldrin, allethrin, allicin, allidochlor, allosamidin, alloxydim, allyl alcohol, allyl isothiocyanate, allyxycarb, alorac, alpha-bromadiolone, alpha-cypermethrin, alpha- endosulfan, alphamethrin, altretamine, aluminium phosphide, aluminum phosphide, ametoctradin, ametridione, ametryn, ametryne, amibuzin, amicarbazone, amicarthiazol, amidithion, amidochlor, amidoflumet, amidosulfuron, aminocarb, aminocyclopyrachlor, 25 aminopyralid, aminopyrifen, aminotriazole, amiprofos-methyl, amiprophos, amiprophos-methyl, amisulbrom, amiton, amitraz, amitrole, ammonium sulfamate, amobam, amorphous silica gel, amorphous silicon dioxide, ampropylfos, AMS, anabasine, ancymidol, anilazine, anilofos, anisiflupurin, anisuron, anthraquinone, antimony potassium tartrate, antu, apholate, aramite, arprocarb, arsenous oxide, asomate, asulam, athidathion, atraton, atrazine, aureofungin, 30 avermectin B1, AVG, aviglycine, azaconazole, azadirachtin, azafenidin, azamethiphos, 212203-WO-SEC-1 Page 9 of 152 azidithion, azimsulfuron, azinphosethyl, azinphos-ethyl, azinphosmethyl, azinphos-methyl, aziprotryn, aziprotryne, azithiram, azobenzene, azocyclotin, azothoate, azoxystrobin, bachmedesh, barban, barbanate, barium hexafluorosilicate, barium polysulfide, barium silicofluoride, barthrin, basic copper carbonate, basic copper chloride, basic copper sulfate, 5 BCPC, beflubutamid, beflubutamid-M, benalaxyl, benalaxyl-M, benazolin, bencarbazone, benclothiaz, bendaqingbingzhi, bendiocarb, bendioxide, benefin, benfluralin, benfuracarb, benfuresate, benmihuangcaoan, benodanil, benomyl, benoxacor, benoxafos, benquinox, benquitrione, bensulfuron, bensulide, bensultap, bentaluron, bentazon, bentazone, benthiavalicarb, benthiazole, benthiocarb, bentranil, benzadox, benzalkonium chloride, 10 benzamacril, benzamizole, benzamorf, benzene hexachloride, benzfendizone, benzimine, benzipram, benzobicyclon, benzoepin, benzofenap, benzofluor, benzohydroxamic acid, benzomate, benzophosphate, benzothiadiazole, benzovindiflupyr, benzoximate, benzoylprop, benzpyrimoxan, benzthiazuron, benzuocaotong, benzyl benzoate, benzyladenine, berberine, beta- cyfluthrin, beta-cypermethrin, bethoxazin, BHC, bialaphos, bicyclopyrone, bifenazate, bifenox, 15 bifenthrin, bifujunzhi, bilanafos, binapacryl, bǐnghuánzuò, bingqingxiao, bioallethrin, bioethanomethrin, biopermethrin, bioresmethrin, biphenyl, bipyrazone, bisazir, bismerthiazol, bismerthiazol-copper, bisphenylmercury methylenedi(x-naphthalene-y-sulphonate), bispyribac, bistrifluron, bisultap, bitertanol, bithionol, bixafen, bixlozone, blasticidin-S, borax, Bordeaux mixture, boric acid, boscalid, BPCMS, BPMC, BPPS, brassinolide, brassinolide-ethyl, 20 brevicomin, brodifacoum, brofenprox, brofenvalerate, broflanilide, brofluthrinate, bromacil, bromadiolone, bromchlophos, bromethalin, bromethrin, bromfenvinfos, bromoacetamide, bromobonil, bromobutide, bromociclen, bromocyclen, bromo-DDT, bromofenoxim, bromofos, bromomethane, bromophos, bromophos-ethyl, bromopropylate, bromothalonil, bromoxynil, brompyrazon, brompyrazone, bromuconazole, bronopol, bropropdifacoum, BRP, BTH, 25 bucarpolate, bufencarb, buminafos, bupirimate, buprofezin, Burgundy mixture, busulfan, busulphan, butacarb, butachlor, butafenacil, butam, butamifos, butane-fipronil, butathiofos, butenachlor, butene-fipronil, butethrin, buthidazole, buthiobate, buthiuron, butifos, butocarboxim, butonate, butopyronoxyl, butoxycarboxim, butralin, butrizol, butroxydim, buturon, butylamine, butylate, butylchlorophos, butylene-fipronil, cacodylic acid, cadusafos, 30 cafenstrole, calciferol, calcium arsenate, calcium chlorate, calcium cyanamide, calcium cyanide, calcium polysulfide, calvinphos, cambendichlor, camphechlor, camphor, cantrodifene, captafol, 212203-WO-SEC-1 Page 10 of 152 captan, carbam, carbamorph, carbanolate, carbaril, carbaryl, carbasulam, carbathiin, carbathion, carbendazim, carbendazol, carbetamide, carbofenotion, carbofuran, carbon disulfide, carbon tetrachloride, carbonyl sulfide, carbophenothion, carbophos, carbosulfan, carboxazole, carboxide, carboxin, carfentrazone, carpropamid, cartap, carvacrol, carvone, CAVP, CDAA, 5 CDEA, CDEC, cellocidin, CEPC, ceralure, cerenox, cetoctaelat, cevadilla, Cheshunt mixture, chinalphos, chinalphos-méthyl, chinomethionat, chinomethionate, chiralaxyl, chitosan, chlobenthiazone, chlomethoxyfen, chloralose, chloramben, chloramine phosphorus, chloramizol, chloramphenicol, chloraniformethan, chloranil, chloranocryl, chlorantraniliprole, chlorazifop, chlorazine, chlorbenside, chlorbenzuron, chlorbicyclen, chlorbromuron, chlorbufam, chlordane, 10 chlordecone, chlordimeform, chlorempenthrin, chloretazate, chlorethephon, chlorethoxyfos, chloreturon, chlorfenac, chlorfenapyr, chlorfenazole, chlorfenethol, chlorfenidim, chlorfenprop, chlorfenson, chlorfensulphide, chlorfenvinphos, chlorfenvinphos-methyl, chlorfluazuron, chlorflurazole, chlorflurecol, chlorfluren, chlorflurenol, chloridazon, chlorimuron, chlorinate, chlor-IPC, chlormephos, chlormequat, chlormesulone, chlormethoxynil, chlornidine, 15 chlornitrofen, chloroacetic acid, chlorobenzilate, chlorodinitronaphthalenes, chlorofénizon, chloroform, chloroinconazide, chloromebuform, chloromethiuron, chloroneb, chlorophacinone, chlorophos, chlorophthalim, chloropicrin, chloropon, chloroprallethrin, chloropropylate, chlorothalonil, chlorotoluron, chloroxifenidim, chloroxuron, chloroxynil, chlorphonium, chlorphoxim, chlorphthalim, chlorprazophos, chlorprocarb, chlorpropham, chlorpyrifos, 20 chlorpyrifos-methyl, chlorquinox, chlorsulfuron, chlorthal, chlorthiamid, chlorthiophos, chlortoluron, chlozolinate, chltosan, cholecalciferol, choline chloride, chromafenozide, cicloheximide, cimectacarb, cimetacarb, cinerin I, cinerin II, cinerins, cinidon-ethyl, cinmethylin, cinosulfuron, cintofen, ciobutide, cisanilide, cismethrin, clacyfos, clefoxydim, clenpirin, clenpyrin, clethodim, climbazole, cliodinate, clodinafop, cloethocarb, clofencet, clofenotane, 25 clofentezine, clofenvinfos, clofibric acid, clofop, clomazone, clomeprop, clonitralid, clopindol, cloprop, cloproxydim, clopyralid, cloquintocet, cloransulam, closantel, clothianidin, clotrimazole, cloxyfonac, cloxylacon, clozylacon, CMA, CMMP, CMP, CMU, codlelure, colecalciferol, colophonate, copper 8-quinolinolate, copper acetate, copper acetoarsenite, copper arsenate, copper carbonate, basic copper hydroxide, copper naphthenate, copper oleate, copper 30 oxychloride, copper silicate, copper sulfate, copper sulfate, basic, copper zinc chromate, coumachlor, coumafène, coumafos, coumafuryl, coumaphos, coumatetralyl, coumethoxystrobin, 212203-WO-SEC-1 Page 11 of 152 coumithoate, coumoxystrobin, CPMC, CPMF, CPPC, credazine, cresol, cresylic acid, crimidine, croconazole, crotamiton, crotoxyfos, crotoxyphos, crufomate, cryolite, cue-lure, cufraneb, cumyleron, cumyluron, cuprobam, cuprous oxide, curcumenol, CVMP, cyanamide, cyanatryn, cyanazine, cyanofenphos, cyanogen, cyanophos, cyanthoate, cyantraniliprole, cyanuric acid, 5 cyazofamid, cybutryne, cyclafuramid, cyclanilide, cyclaniliprole, cyclethrin, cycloate, cyclobutrifluram, cycloheximide, cycloprate, cycloprothrin, cyclopyranil, cyclopyrimorate, cyclosulfamuron, cycloxaprid, cycloxydim, cycluron, cyenopyrafen, cyetpyrafen, cyflufenamid, cyflumetofen, cyfluthrin, cyhalodiamide, cyhalofop, cyhalothrin, cyhexatin, cymergan, cymiazole, cymoxanil, cyometrinil, cypendazole, cypermethrin, cyperquat, cyphenothrin, 10 cyprazine, cyprazole, cyproconazole, cyprodinil, cyproflanilide, cyprofuram, cypromid, cyprosulfamide, cypyrafluone, cyromazine, cythioate, cytrex, DA-6, daimuron, dalapon, daminozide, dayoutong, dazomet, DBCP, d-camphor, DCB, DCD, DCIP, DCPA (Japan), DCPA (USA), DCPTA, DCU, DDD, DDPP, DDT, DDVP, debacarb, decafentin, decamethrin, decarbofuran, deet, dehydroacetic acid, deiquat, delachlor, delnav, deltamethrin, demephion, 15 demephion-O, demephion-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S-methyl sulphone, demeton-S-methylsulphon, DEP, depalléthrine, derris, desmedipham, desmetryn, desmetryne, d-fanshiluquebingjuzhi, DFDT, diafenthiuron, dialifor, dialifos, diallate, di-allate, diamidafos, diamiphenethide, dianat, diatomaceous earth, diatomite, diazinon, dibrom, dibutyl phthalate, dibutyl succinate, dicamba, 20 dicapthon, dicarbasulf, dicarbosulf, dichlobenil, dichlobentiazox, dichlobenz-methyl, dichlofenthion, dichlofluanid, dichlone, dichloralurea, dichlorbenzuron, dichlorfenidim, dichlorflurecol, dichlorflurenol, dichlormate, dichlormid, dichloromethane, dichlorophen, dichlorprop, dichlorprop-P, dichlorvos, dichlozolin, dichlozoline, diclobutrazol, diclocymet, diclofop, diclomezine, dicloran, dicloromezotiaz, diclosulam, dicofol, dicophane, dicoumarol, 25 dicresyl, dicrotophos, dicryl, dicumarol, dicyclanil, dicyclonon, dieldrin, dienochlor, diethamquat, diethatyl, diethion, diéthion, diethofencarb, dietholate, diéthon, diethyl pyrocarbonate, diethyltoluamide, difenacoum, difenoconazole, difenopenten, difenoxuron, difenzoquat, difethialone, diflovidazin, diflubenzuron, diflufenican, diflufenicanil, diflufenzopyr, diflumetorim, dikegulac, dilor, dimatif, dimefluazole, dimefluthrin, dimefox, dimefuron, 30 dimehypo, dimenoxypyrin, dimepiperate, dimesulfazet, dimetachlone, dimetan, dimethacarb, dimethachlone, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, 212203-WO-SEC-1 Page 12 of 152 dimethirimol, dimethoate, dimethomorph, dimethrin, dimethyl carbate, dimethyl disulfide, dimethyl phthalate, dimethylvinphos, dimetilan, dimexano, dimidazon, dimoxystrobin, dimpropyridaz, dimpylate, dimuron, dinex, dingjunezuo, diniconazole, diniconazole-M, dinitramine, dinitrophenols, dinobuton, dinocap, dinocap-4, dinocap-6, dinocton, dinofenate, 5 dinopenton, dinoprop, dinosam, dinoseb, dinosulfon, dinotefuran, dinoterb, dinoterbon, diofenolan, dioxabenzofos, dioxacarb, dioxathion, dioxation, dioxopyritrione, diphacin, diphacinone, diphenadione, diphenamid, diphenamide, diphenyl sulfone, diphenyl sulphide, diphenylamine, diprogulic acid, dipropalin, dipropetryn, dipterex, dipymetitrone, dipyrithione, diquat, disodium tetraborate, disosultap, disparlure, disugran, disul, disulfiram, disulfoton, 10 ditalimfos, dithianon, dithicrofos, dithioether, dithiométon, dithiopyr, dithiuron, diuron, dixanthogen, d-limonene, DMDS, DMPA, DNOC, dodemorph, dodicin, dodine, dofenapyn, doguadine, dominicalure, doramectin, DPC, drazoxolon, DSMA, d-teflumethrin, d-trans- allethrin, d-trans-resmethrin, dufulin, dymron, EBEP, EBP, ebufos, ecdysterone, echlomezol, EDB, EDC, EDDP, edifenphos, eglinazine, emamectin, EMPC, empenthrin, enadenine, 15 endosulfan, endothal, endothall, endothion, endrin, enestroburin, enilconazole, enoxastrobin, ephirsulfonate, EPN, epocholeone, epofenonane, epoxiconazole, eprinomectin, epronaz, epsilon- metofluthrin, epsilon-momfluorothrin, EPTC, epyrifenacil, erbon, ergocalciferol, erlujixiancaoan, esafoxolaner, esdépalléthrine, esfenvalerate, ESP, esprocarb, etacelasil, etaconazole, etaphos, etem, ethaboxam, ethachlor, ethalfluralin, ethametsulfuron, ethaprochlor,20 ethephon, ethidimuron, ethiofencarb, ethiolate, ethion, ethiozin, ethiprole, ethirimol, ethoate- methyl, ethobenzanid, ethofumesate, ethohexadiol, ethoprop, ethoprophos, ethoxyfen, ethoxyquin, ethoxysulfuron, ethychlozate, ethyl formate, ethyl pyrophosphate, ethylan, ethyl- DDD, ethylene, ethylene dibromide, ethylene dichloride, ethylene oxide, ethylicin, ethylmercury 2,3-dihydroxypropyl mercaptide, ethylmercury acetate, ethylmercury bromide, ethylmercury 25 chloride, ethylmercury phosphate, ethylthiometon, ethyltrianol, etiltrianol, etinofen, ETM, etnipromid, etobenzanid, etofenprox, etoxazole, etridiazole, etrimfos, eugenol, EXD, famoxacarb, famoxadone, famphur, fenac, fenamidone, fenaminosulf, fenaminstrobin, fenamiphos, fenapanil, fenarimol, fenasulam, fenazaflor, fenazaquin, fenbuconazole, fenbutatin oxide, fenchlorazole, fenchlorphos, fenclofos, fenclorim, fenethacarb, fenetrazole, fenfluthrin, 30 fenfuram, fenhexamid, fenidim, fenitropan, fenitrothion, fénizon, fenjuntong, fenmezoditiaz, fenobucarb, fenolovo, fenoprop, fenothiocarb, fenoxacrim, fenoxanil, fenoxaprop, fenoxaprop-P, 212203-WO-SEC-1 Page 13 of 152 fenoxasulfone, fenoxycarb, fenpiclonil, fenpicoxamid, fenpirithrin, fenpropathrin, fenpropidin, fenpropimorph, fenpyrazamine, fenpyrazone, fenpyroximate, fenquinotrione, fenridazon, fenson, fensulfothion, fenteracol, fenthiaprop, fenthion, fenthion-ethyl, fentiaprop, fentin, fentrazamide, fentrifanil, fenuron, fenuron-TCA, fenvalerate, ferbam, ferimzone, ferric phosphate, ferrous 5 sulfate, fipronil, flamprop, flamprop-M, flazasulfuron, flocoumafen, flometoquin, flonicamid, florasulam, florpyrauxifen, florylpicoxamid, fluacrypyrim, fluazaindolizine, fluazifop, fluazifop- P, fluazinam, fluazolate, fluazuron, flubendiamide, flubeneteram, flubenzimine, flubrocythrinate, flucarbazone, flucetosulfuron, fluchloralin, fluchloraminopyr, fluchlordiniliprole, flucofuron, flucycloxuron, flucythrinate, fludioxonil, fluénéthyl, fluenetil, fluensulfone, flufenacet, 10 flufenerim, flufenican, flufenoxadiazam, flufenoximacil, flufenoxuron, flufenoxystrobin, flufenprox, flufenpyr, flufenzine, flufiprole, fluhexafon, fluindapyr, flumethrin, flumetover, flumetralin, flumetsulam, flumetylsulforim, flumezin, flumiclorac, flumioxazin, flumipropyn, flumorph, fluometuron, fluopicolide, fluopimomide, fluopyram, flupyroxystrobin fluorbenside, fluoridamid, fluoroacetamide, fluoroacetic acid, fluorochloridone, fluoro-DDT, fluorodifen, 15 fluorogesarol, fluoroglycofen, fluoroimide, fluoromide, fluoromidine, fluoronitrofen, fluoroxypyr, fluothiuron, fluotrimazole, fluoxapiprolin, fluoxastrobin, fluoxytioconazole, flupentiofenox, flupoxam, flupropacil, flupropadine, flupropanate, flupyradifurone, flupyrazofos, flupyrimin, flupyrsulfuron, fluquinconazole, fluralaner, flurazole, flurecol, flurenol, fluridone, flurochloridone, fluromidine, fluroxypyr, flurprimidol, flursulamid, flurtamone, flusilazole, 20 flusulfamide, flusulfinam flutenzine, fluthiacet, fluthiamide, flutianil, flutolanil, flutriafol, fluvalinate, fluxametamide, fluxapyroxad, fluxofenim, folpel, folpet, fomesafen, fonofos, foramsulfuron, forchlorfenuron, formaldehyde, formetanate, formothion, formparanate, fosamine, fosetyl, fosmethilan, fospirate, fosthiazate, fosthietan, frontalin, fthalide, fuberidazole, fucaojing, fucaomi, fufenozide, fujunmanzhi, fulumi, fumarin, funaihecaoling, fuphenthiourea, 25 furalane, furalaxyl, furamethrin, furametpyr, furan tebufenozide, furathiocarb, furcarbanil, furconazole, furconazole-cis, furethrin, furfural, furilazole, furmecyclox, furophanate, furyloxyfen, gamma-BHC, gamma-cyhalothrin, gamma-HCH, genit, gibberellic acid, gibberellin A3, gibberellins, gliftor, glitor, glucochloralose, glufosinate, glufosinate-P, glyodin, glyoxime, glyphosate, glyphosine, gossyplure, grandlure, griseofulvin, guanoctine, guazatine, halacrinate,30 halauxifen, halfenprox, halofenozide, halosafen, halosulfuron, haloxydine, haloxyfop, haloxyfop- P, haloxyfop-R, HCA, HCB, HCH, hemel, hempa, HEOD, heptachlor, heptafluthrin, 212203-WO-SEC-1 Page 14 of 152 heptamaloxyloglucan, heptenophos, heptopargil, herbimycin, herbimycin A, heterophos, hexachlor, hexachloran, hexachloroacetone, hexachlorobenzene, hexachlorobutadiene, hexachlorophene, hexaconazole, hexaflumuron, hexafluoramin, hexaflurate, hexalure, hexamide, hexazinone, hexylthiofos, hexythiazox, HHDN, holosulf, homobrassinolide, huanbifucaotong, 5 huancaiwo, huanchongjing, huangcaoling, huanjunzuo, hydramethylnon, hydrargaphen, hydrated lime, hydrogen cyanamide, hydrogen cyanide, hydroprene, hydroxyisoxazole, hymexazol, hyquincarb, IAA, IBA, IBP, icaridin, imazalil, imazamethabenz, imazamethapyr, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, imazosulfuron, imibenconazole, imicyafos, imidacloprid, imidaclothiz, iminoctadine, imiprothrin, inabenfide, indanofan, indazapyroxamet, 10 indaziflam, indoxacarb, inezin, infusorial earth, inpyrfluxam, iodobonil, iodocarb, iodofenphos, iodomethane, iodosulfuron, iofensulfuron, ioxynil, ipazine, IPBC, IPC, ipconazole, ipfencarbazone, ipfentrifluconazole, ipflufenoquin, iprobenfos, iprodione, iprovalicarb, iprymidam, ipsdienol, ipsenol, IPSP, iptriazopyrid , IPX, isamidofos, isazofos, isobenzan, isocarbamid, isocarbamide, isocarbophos, isocil, isocycloseram, isodrin, isofenphos, isofenphos- 15 methyl, isofetamid, isoflucypram, isolan, isomethiozin, isonoruron, isopamphos, isopolinate, isoprocarb, isoprocil, isopropalin, isopropazol, isoprothiolane, isoproturon, isopyrazam, isopyrimol, isothioate, isotianil, isouron, isovaledione, isoxaben, isoxacarbole, isoxachlortole, isoxadifen, isoxaflutole, isoxapyrifop, isoxathion, isuron, ivermectin, ixoxaben, izopamfos, izopamphos, japonilure, japothrins, jasmolin I, jasmolin II, jasmonic acid, jiahuangchongzong, 20 jiajizengxiaolin, jiaxiangjunzhi, jiecaowan, jiecaoxi, Jinganmycin A, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kadethrin, kappa-bifenthrin, kappa- tefluthrin, karbutilate, karetazan, kasugamycin, kejunlin, kelevan, ketospiradox, kieselguhr, kinetin, kinoprene, kiralaxyl, kresoxim-methyl, kuicaoxi, lactofen, lambda-cyhalothrin, lancotrione, latilure, lead arsenate, lenacil, lepimectin, leptophos, L-glufosinate, lianbenjingzhi, 25 lime sulfur, lindane, lineatin, linuron, lirimfos, litlure, looplure, lotilaner, lufenuron, lüfuqingchongxianan, lüxiancaolin, lvdingjunzhi, lvfumijvzhi, lvxiancaolin, lythidathion, M-74, M-81, MAA, magnesium phosphide, malathion, maldison, maleic hydrazide, malonoben, maltodextrin, MAMA, manam, mancopper, mancozeb, mandestrobin, mandipropamid, maneb, matrine, mazidox, MCA, MCC, MCP, MCPA, MCPA-thioethyl, MCPB, MCPP, mebenil, 30 mecarbam, mecarbinzid, mecarphon, mecoprop, mecoprop-P, medimeform, medinoterb, medlure, mefenacet, mefenoxam, mefenpyr, mefentrifluconazole, mefluidide, megatomoic acid, 212203-WO-SEC-1 Page 15 of 152 melissyl alcohol, melitoxin, MEMC, menazon, MEP, mepanipyrim, meperfluthrin, mephenate, mephosfolan, mepiquat, mepitriflufenpyr, mepronil, meptyldinocap, mercaptodimethur, mercaptophos, mercaptophos thiol, mercaptothion, mercuric chloride, mercuric oxide, mercurous chloride, merphos, merphos oxide, mesoprazine, mesosulfuron, mesotrione, mesulfen, 5 mesulfenfos, mesulphen, metacresol, metaflumizone, metalaxyl, metalaxyl-M, metaldehyde, metam, metamifop, metamitron, metaphos, metarylpicoxamid, metaxon, metazachlor, metazosulfuron, metazoxolon, metcamifen, metconazole, metepa, metflurazon, methabenzthiazuron, methacrifos, methalpropalin, metham, methamidophos, methasulfocarb, methazole, methfuroxam, methibenzuron, methidathion, methiobencarb, methiocarb, 10 methiopyrisulfuron, methiotepa, methiozolin, methiuron, methocrotophos, métholcarb, methometon, methomyl, methoprene, methoprotryn, methoprotryne, methoquin-butyl, methothrin, methoxychlor, methoxyfenozide, methoxyphenone, methyl apholate, methyl bromide, methyl eugenol, methyl iodide, methyl isothiocyanate, methyl parathion, methylacetophos, methylchloroform, methyldithiocarbamic acid, methyldymron, methylene 15 chloride, methyl-isofenphos, methylmercaptophos, methylmercaptophos oxide, methylmercaptophos thiol, methylmercury benzoate, methylmercury dicyandiamide, methylmercury pentachlorophenoxide, methylneodecanamide, methylnitrophos, methyltriazothion, metiozolin, metiram, metiram-zinc, metobenzuron, metobromuron, metofluthrin, metolachlor, metolcarb, metomeclan, metometuron, metominostrobin, metosulam, 20 metoxadiazone, metoxuron, metrafenone, metriam, metribuzin, metrifonate, metriphonate, metsulfovax, metsulfuron, metyltetraprole, mevinphos, mexacarbate, miechuwei, mieshuan, miewenjuzhi, milbemectin, milbemycin oxime, milneb, mimanan, mipafox, MIPC, mirex, MITC, mivorilaner, MNAF, modoflaner, moguchun, molinate, molosultap, momfluorothrin, monalide, monisouron, monisuron, monoamitraz, monochloroacetic acid, monocrotophos, 25 monolinuron, monomehypo, monosulfiram, monosulfuron, monosulfuron-ester, monosultap, monuron, monuron-TCA, morfamquat, moroxydine, morphothion, morzid, moxidectin, MPMC, MSMA, MTMC, muscalure, myclobutanil, myclozolin, myricyl alcohol, N-(ethylmercury)-p- toluenesulfonanilide, N-(ethylmercury)-p-toluenesulphonanilide, NAA, NAAm, nabam, naftalofos, naled, naphthalene, naphthaleneacetamide, naphthalic anhydride, naphthalophos, 30 naphthoxyacetic acids, naphthylacetic acids, naphthylindane-1,3-diones, naphthyloxyacetic acids, naproanilide, napropamide, napropamide-M, naptalam, natamycin, NBPOS, neburea, 212203-WO-SEC-1 Page 16 of 152 neburon, nendrin, neonicotine, nichlorfos, niclofen, niclosamide, nicobifen, nicofluprole, nicosulfuron, nicotine, nifluridide, nikkomycins, ningnamycin, ningnanmycin, NIP, nipyraclofen, nipyralofen, nitenpyram, nithiazine, nitralin, nitrapyrin, nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, NNM, nobormide, nonanol, norbormide, norea, 5 norflurazon, nornicotine, noruron, novaluron, noviflumuron, NPA, nuarimol, nuranone, OCH, octachlorodipropyl ether, octhilinone, o-dichlorobenzene, ofurace, omethoate, o-phenylphenol, orbencarb, orfralure, orthobencarb, ortho-dichlorobenzene, orthonil, orthosulfamuron, oryctalure, orysastrobin, oryzalin, osthol, osthole, ostramone, ovatron, ovex, oxabetrinil, oxadiargyl, oxadiazon, oxadixyl, oxamate, oxamyl, oxapyrazon, oxapyrazone, oxasulfuron, 10 oxathiapiprolin, oxaziclomefone, oxazosulfyl, oxine-copper, oxine-Cu, oxolinic acid, oxpoconazole, oxycarboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyenadenine, oxyfenthiin, oxyfenthin, oxyfluorfen, oxymatrine, oxytetracycline, oxythioquinox, PAC, paclobutrazol, paichongding, palléthrine, PAP, para-dichlorobenzene, parafluron, paraquat, parathion, parathion-methyl, parinol, Paris green, PCNB, PCP, PCP-Na, p-dichlorobenzene, PDJ, 15 pebulate, pédinex, pefurazoate, pelargonic acid, penconazole, pencycuron, pendimethalin, penfenate, penflufen, penfluron, penoxalin, penoxsulam, pentachlorophenol, pentachlorophenyl laurate, pentanochlor, penthiopyrad, pentmethrin, pentoxazone, perbutin, perchlordecone, perfluidone, permethrin, perthane, pethoxamid, PHC, phenamacril, phenamacril-ethyl, phénaminosulf, phenazine oxide, phénétacarbe, phenisopham, phenkapton, phenmedipham, 20 phenmedipham-ethyl, phenobenzuron, phenothiol, phenothrin, phenproxide, phenthoate, phenylmercuriurea, phenylmercury acetate, phenylmercury chloride, phenylmercury derivative of pyrocatechol, phenylmercury nitrate, phenylmercury salicylate, phorate, phosacetim, phosalone, phosametine, phosazetim, phosazetin, phoscyclotin, phosdiphen, phosethyl, phosfolan, phosfolan-methyl, phosglycin, phosmet, phosnichlor, phosphamide, phosphamidon, 25 phosphine, phosphinothricin, phosphocarb, phosphorus, phostebupirim, phostin, phoxim, phoxim-methyl, phthalide, phthalophos, phthalthrin, picarbutrazox, picaridin, picloram, picolinafen, picoxystrobin, pimaricin, pindone, pinoxaden, piperalin, piperazine, piperonyl butoxide, piperonyl cyclonene, piperophos, piproctanly, piproctanyl, piprotal, pirimetaphos, pirimicarb, piriminil, pirimioxyphos, pirimiphos-ethyl, pirimiphos-methyl, pival, pivaldione, 30 plifenate, PMA, PMP, polybutenes, polycarbamate, polychlorcamphene, polyethoxyquinoline, polyoxin D, polyoxins, polyoxorim, polyram, polythialan, potassium arsenite, potassium azide, 212203-WO-SEC-1 Page 17 of 152 potassium cyanate, potassium ethylxanthate, potassium naphthenate, potassium polysulfide, potassium thiocyanate, pp′-DDT, prallethrin, precocene I, precocene II, precocene III, pretilachlor, primidophos, primisulfuron, probenazole, prochloraz, proclonol, procyazine, procymidone, prodiamine, profenofos, profluazol, profluralin, profluthrin, profoxydim, profurite- 5 aminium, proglinazine, prohexadione, prohydrojasmon, promacyl, promecarb, prometon, prometryn, prometryne, promurit, pronamide, pronitridine, propachlor, propafos, propamidine, propamocarb, propanil, propaphos, propaquizafop, propargite, proparthrin, propazine, propetamphos, propham, propiconazole, propidine, propineb, propisochlor, propoxur, propoxycarbazone, propyl isome, propyrisulfuron, propyzamide, proquinazid, prosuler, 10 prosulfalin, prosulfocarb, prosulfuron, prothidathion, prothiocarb, prothioconazole, prothiofos, prothoate, protrifenbute, proxan, prymidophos, prynachlor, psoralen, psoralene, pydanon, pydiflumetofen, pyflubumide, pymetrozine, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen, pyrafluprole, pyramat, pyrametostrobin, pyraoxystrobin, pyrapropoyne, pyrasulfotole, pyraziflumid, pyrazolate, pyrazolynate, pyrazon, pyrazophos, pyrazosulfuron,15 pyrazothion, pyrazoxyfen, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyribambenz- isopropyl, pyribambenz-propyl, pyribencarb, pyribenzoxim, pyributicarb, pyriclor, pyridaben, pyridachlometyl, pyridafol, pyridalyl, pyridaphenthion, pyridaphenthione, pyridate, pyridinitril, pyrifenox, pyriflubenzoxim, pyrifluquinazon, pyriftalid, pyrimétaphos, pyrimethanil, pyrimicarbe, pyrimidifen, pyriminobac, pyriminostrobin, pyrimiphos-éthyl, pyrimiphos-méthyl, 20 pyrimisulfan, pyrimitate, pyrinuron, pyriofenone, pyriprole, pyripropanol, pyriproxyfen, pyrisoxazole, pyrithiobac, pyrolan, pyroquilon, pyroxasulfone, pyroxsulam, pyroxychlor, pyroxyfur, qincaosuan, qingkuling, quassia, quinacetol, quinalphos, quinalphos-methyl, quinazamid, quinclorac, quinconazole, quinmerac, quinoclamine, quinofumelin, quinomethionate, quinonamid, quinothion, quinotrione, quinoxyfen, quintiofos, quintozene,25 quintrione, quizalofop, quizalofop-P, quwenzhi, quyingding, rabenzazole, rafoxanide, R- diniconazole, rebemide, reglone, renofluthrin, renriduron, rescalure, resmethrin, rhodethanil, rhodojaponin-III, ribavirin, rimisoxafen, rimsulfuron, rizazole, R-metalaxyl, rodéthanil, ronnel, rotenone, ryania, sabadilla, saflufenacil, saijunmao, saisentong, salicylanilide, salifluofen, sanguinarine, santonin, sarolaner, S-bioallethrin, schradan, scilliroside, seboctylamine, 30 sebuthylazine, secbumeton, sedaxane, selamectin, semiamitraz, sesamex, sesamolin, sesone, sethoxydim, sevin, shuangjiaancaolin, shuangjianancaolin, S-hydroprene, siduron, sifumijvzhi, 212203-WO-SEC-1 Page 18 of 152 siglure, silafluofen, silatrane, silica aerogel, silica gel, silthiofam, silthiopham, silthiophan, silvex, simazine, simeconazole, simeton, simetryn, simetryne, sintofen, S-kinoprene, slaked lime, SMA, S-methoprene, S-metolachlor, sodium arsenite, sodium azide, sodium chlorate, sodium chloroacetate, sodium cyanide, sodium fluoride, sodium fluoroacetate, sodium 5 hexafluorosilicate, sodium naphthenate, sodium orthophenylphenoxide, sodium pentachlorophenate, sodium pentachlorophenoxide, sodium polysulfide, sodium silicofluoride, sodium tetrathiocarbonate, sodium thiocyanate, sodium o-phenylphenoxide, solan, sophamide, spidoxamat, spinetoram, spinosad, spirobudifen, spirodiclofen, spiromesifen, spiropidion, spirotetramat, spiroxamine, stirofos, streptomycin, strychnine, sulcatol, sulcofuron, sulcotrione, 10 sulfallate, sulfathiadiazuron, sulfathiazuron, sulfentrazone, sulfiram, sulfluramid, sulfodiazole, sulfometuron, sulfosate, sulfosulfuron, sulfotep, sulfotepp, sulfoxaflor, sulfoxide, sulfoxime, sulfur, sulfuric acid, sulfuryl fluoride, sulglycapin, sulphosate, sulprofos, sultropen, supermethrin, suthiazuron, swep, tartar emetic, tau-fluvalinate, tavron, tazimcarb, TBTO, TBZ, TCA, TCBA, TCMTB, TCNB, TDE, tebuconazole, tebufenozide, tebufenpyrad, tebufloquin, 15 tebupirimfos, tebupirimphos, tebutam, tebuthiuron, tecloftalam, tecnazene, tecoram, tedion, teflubenzuron, tefluthrin, tefuryltrione, tembotrione, temefos, temephos, tepa, TEPP, tepraloxydim, teproloxydim, terallethrin, terbacil, terbucarb, terbuchlor, terbuconazole, terbufos, terbumeton, terbuthylazine, terbutol, terbutrazole, terbutryn, terbutryne, terraclor, terramicin, terramycin, tetcyclacis, tetflupyrolimet, tetrachlorantraniliprole, tetrachloroethane, 20 tetrachlorvinphos, tetraconazole, tetradifon, tetradisul, tetrafluron, tetramethrin, tetramethylfluthrin, tetramine, tetranactin, tetraniliprole, tetrapion, tetrasul, thallium sulfate, thallous sulfate, thenylchlor, theta-cypermethrin, thiabendazole, thiacloprid, thiadiazine, thiadifluor, thiamethoxam, thiameturon, thiapronil, thiazafluron, thiazfluron, thiazone, thiazopyr, thicrofos, thicyofen, thidiazimin, thidiazuron, thiencarbazone, thifensulfuron, thifluzamide, 25 thimerosal, thimet, thiobencarb, thiocarboxime, thiochlorfenphim, thiocyanatodinitrobenzenes, thiocyclam, thiodan, thiodemeton, thiodiazole-copper, thiodicarb, thiofanocarb, thiofanox, thiofluoximate, thiohempa, thiomersal, thiometon, thionazin, thiophanate, thiophanate-ethyl, thiophanate-methyl, thiophos, thioquinox, thiosemicarbazide, thiosultap, thiotepa, thioxamyl, thiram, thiuram, thuringiensin, tiabendazole, tiadinil, tiafenacil, tiaojiean, TIBA, tifatol, 30 tigolaner, tiocarbazil, tioclorim, tiorantraniliprole, tioxazafen, tioxymid, tirpate, TMTD, tolclofos-methyl, tolfenpyrad, tolnifanide, tolprocarb, tolpyralate, tolyfluanid, tolylfluanid, tolylmercury acetate, tomarin, topramezone, toxaphene, TPN, tralkoxydim, tralocythrin, tralomethrin, tralopyril, transfluthrin, transpermethrin, tretamine, triacontanol, triadimefon, triadimenol, triafamone, triallate, tri-allate, triamiphos, triapenthenol, triarathene, triarimol, triasulfuron, triazamate, triazbutil, triaziflam, triazofenamide, triazophos, triazothion, triazoxide, tribasic copper chloride, tribasic copper sulfate, tribenuron, tribufos, tributyltin oxide, tricamba, trichlamide, trichlophenidine, trichlopyr, trichlorfon, trichlormetaphos-3, trichloronat, trichloronate, trichlorotrinitrobenzenes, trichlorphon, triclopyr, triclopyricarb, tricresol, tricyclazole, tricyclohexyltin hydroxide, tridemorph, tridiphane, trietazine, trifenmorph, trifenofos, trifloxystrobin, trifloxysulfuron, trifludimoxazin, trifluenfuronate, triflumezopyrim, triflumizole, triflumuron, trifluralin, triflusulfuron, trifop, trifopsime, triforine, trihydroxytriazine, trimedlure, trimefluor, trimethacarb, trimeturon, trimorfamid, trimorphamide, trinexapac, triphenyltin, triprene, tripropindan, triptolide, tripyrasulfone, tritac, trithialan, triticonazole, tritosulfuron, tropital, trunc-call, tuoyelin, tyclopyrazoflor, umifoxolaner, uniconazole, uniconazole-P, urbacide, uredepa, valerate, validamycin, validamycin A, valifenalate, valone, vamidothion, vangard, vaniliprole, verbutin, vernolate, vinclozolin, viniconazole, vitamin D3, warfarin, xiaochongliulin, xinjunan, xiwojunan, xiwojunzhi, XMC, xylachlor, xylenols, xyloxadine, xylylcarb, xymiazole, yishijing, zarilamid, zeatin, zengxiaoan, zengxiaolin, zeta-cypermethrin, zinc naphthenate, zinc phosphide, zinc thiazole, zinc thiozole, zinc trichlorophenate, zinc trichlorophenoxide, zineb, ziram, zolaprofos, zoocoumarin, zoxamide, zuoanjunzhi, zuocaoan, zuojunzhi, zuomihuanglong, α-chlorohydrin, α-ecdysone, α- multistriatin, α-naphthaleneacetic acids, and β-ecdysone. These common names may be found in several locations, such as, the British Crop Production Council’s “Compendium of Pesticide Common Names” located at https: / / pesticidecompendium.bcpc.org / . The term “AIGA-1” means the following preferred group of pesticides - Abamectin, Acephate, Acequinocyl, Acrinathrin, Acynonapyr, Afidopyropen, Alanycarb, Aldicarb, Allethrin, alpha-Cypermethrin, Amitraz, Azadirachtin, Azamethiphos, Azinphos-ethyl, Azinphos-methyl, Azocyclotin, Azoxystrobin, Bacillus amyloliquefaciens PTA4838, Bacillus amyloliquefaciens MBI 600, Bendiocarb, Benfuracarb, Bensultap, Benzoximate, Benzpyrimoxan, beta-Cyfluthrin, beta-Cypermethrin, Bifenazate, Bifenthrin, Bioallethrin, Bioresmethrin, Bistrifluron, Broflanilide, Bromopropylate, Buprofezin, Butocarboxim, Butoxycarboxim, Cadusafos, Carbaryl, Carbofuran, Carbosulfan, Cartap hydrochloride, 212203-WO-SEC-1 Page 20 of 152 Chinomethionat, Chlorantraniliprole, Chlordane, Chlorethoxyfos, Chlorfenapyr, Chlorfenvinphos, Chlorfluazuron, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Chromafenozide, Clofentezine, Clothianidin, Coumaphos, Cyanophos, Cyantraniliprole, Cyclaniliprole, Cycloprothrin, Cyenopyrafen, Cyflumetofen, Cyfluthrin, beta-Cyfluthrin, 5 Cyhalothrin, gamma-Cyhalothrin, lambda-Cyhalothrin, Cyhexatin, Cypermethrin, Cyphenothrin, Cyromazine, d-cis-trans Allethrin, DDVP, Deltamethrin, Demeton-S-methyl, Diafenthiuron, Diazinon, Dichlorvos, Dicofol, Dicrotophos, Diflovidazin, Diflubenzuron, Dimethoate, Dimethylvinphos, Disulfoton, DNOC, d-trans Allethrin, Emamectin benzoate, Empenthrin, Endosulfan, EPN, Esfenvalerate, Ethaboxam, Ethiofencarb, Ethion, Ethiprole, Ethoprophos, 10 Etofenprox, Famphur, Fenamiphos, Fenazaquin, Fenbutatin oxide, Fenitrothion, Fenobucarb, Fenoxycarb, Fenpropathrin, Fenpyroximate, Fenthion, Fenvalerate, Fipronil, Flonicamid, Fluacrypyrim, Flubendiamide, Flucycloxuron, Flucythrinate, Fludioxonil, Flufenoxuron, Flumethrin, Flupyradifurone, Fluopyram, Fluoxastrobin, Flupyradifurone, Fluxametamide, Formetanate, Fosthiazate, Furathiocarb, gamma-Cyhalothrin, Halfenprox, Halofenozide, 15 Heptenophos, Hexaflumuron, Hexythiazox, Hydramethylnon, Hydroprene, Imicyafos, Imidacloprid, Imiprothrin, Indiflin, Indoxacarb, Inpyrfluxam, Ipconazole, Isocycloseram, Isofenphos, Isoprocarb, Isoxathion, Kadethrin, Kinoprene, lambda-Cyhalothrin, Lepimectin, Lufenuron, Malathion, Mancozeb, Mecarbam, Metaflumizone, Metalaxyl, Metalaxyl-M, Methamidophos, Methidathion, Methiocarb, Methomyl, Methoprene, Methoxychlor, 20 Methoxyfenozide, Metolcarb, Mevinphos, Milbemectin, Monocrotophos, Naled, Novaluron, Noviflumuron, Omethoate, Oxamyl, Oxathiapiprolin, Oxydemeton-methyl, Parathion, Parathion- methyl, Penicillium bilaiae, Penflufen, Permethrin, Phenothrin, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Picoxystrobin, Pirimicarb, Pirimiphos-methyl, Prallethrin, Profenofos, Propargite, Propetamphos, Propoxur, Prothioconazole, Prothiofos, Pydiflumetofen, 25 Pyflubumide, Pymetrozine, Pyraclofos, Pyrethrum, Pyridaben, Pyridalyl, Pyridaphenthion, Pyrifluquinazon, Pyrimidifen, Pyriproxyfen, Quinalphos, Resmethrin, Rotenone, Sedaxane, Silafluofen, Spidoxamat, Spinetoram, Spinosad, Spirodiclofen, Spiromesifen, Spiropidion, Spirotetramat, Sulfluramid, Sulfotep, Sulfoxaflor, tau-Fluvalinate, Tebufenozide, Tebufenpyrad, Tebupirimfos, Teflubenzuron, Tefluthrin, Temephos, Terbufos, Tetrachlorvinphos, Tetradifon, 30 Tetramethrin, Tetraniliprole, theta-cypermethrin, Thiabendazole, Thiocyclam, Thiodicarb, Thiofanox, Thiomethoxam, Thiometon, Thiosultap-sodium, Tolfenpyrad, Tralomethrin, 212203-WO-SEC-1 Page 21 of 152 Transfluthrin, Triazamate, Triazophos, Trichlorfon, Triflumezopyrim, Triflumuron, Trimethacarb, Vamidothion, XMC, Xylylcarb, zeta-Cypermethrin, Bacillus thuringiensis delta endotoxins, entomopathogenic bacteria, entomopathogenic viruses and entomopathogenic fungi. For the avoidance of doubt each of these pesticides is an active ingredient. 5 The term “AIGA-2” means the following preferred group of mixing partners to form mixtures that expand the use of pesticidal compositions perform multiple agricultural functions Abamectin, Acephate, Acetamiprid, Afridopyropen, Benzpyrimoxan, Bifenthrin, Broflanilide, Buprofezin, Chlorantraniliprole, Chlorfenapyr, Chlorpyrifos, Clothianidin, Cyantraniliprole, Cyclaniliprole, Cyclooxapird, Cyproflanilide, Dimpropyridaz, Dinotefuran, Emamectin 10 benzoate, Ethiprole, Fipronil, Flonicamid, Flubendiamide, Flupyradifurone, Flupyrimin, Fluxametamide, Indazapyroxamet, Imidacloprid, Indoxacarb, Isocycloseram, Lambda- Cyhalothrin, Methoxyfenozide, Oxamyl, Oxazasulfyl, Pymetrozine, Pyrifluquinazon, Pyrimetrozine, Pyriproxyfen, Spidoxamat, Spinetoram, Spinosad, Spiromesifen, Spiropidion, spirotetramat, Sulfoxaflor, Tetraniliprole, Thiamethoxam, and Triflumezopyrim. 15 The molecule named N-(3-chloro--(pyridin-3-yl)-1H-pyrazol-4-yl)-2- (methylsulfonyl)propenamide is an active ingredient and for the purpose of this disclosure is defined as “AI-2.” 212203-WO-SEC-1 Page 22 of 152 The molecule named N-(4-chloro-2-(pyridin-3-yl)thiazol-5-yl)-N-ethyl-3- (methylsulfonyl)propenamide is an active ingredient and for the purpose of this disclosure is defined as “AI-1.” 5 The term “AIGA-3” means the following preferred group of mixing partners to form mixtures that expand the use of pesticidal compositions perform multiple agricultural functions; Azoxystrobin, Carboxin, Copper Hydroxide, Cyclobutrifluram, Difenoconazole, Dithiocarbamate, Ethaboxam, Fipronil, Fludioxonil, Fluopyram, Fluoxapiprolin, Fluoxastrobin, Fluxapyroxad, Inpyrfluxam, Ipconazole, Isoflucypram, Mefenoxam, Metalaxyl, Metconazole, 10 Myclobutanil, Oxathiapiprolin, Penflufen, Picarbutrazox, Picoxystrobin, Propiconazole, Prothioconazole, Pydiflumetofen, Pyraclostrobin, Sedaxane, Tebuconazole, Thiabendazole, Thiram, and Trifloxystrobin. The term “AIGA-4” means the following preferred group of mixing partners to form mixtures that expand the use of pesticidal compositions perform multiple agricultural functions; 15 Reklemel (fluazaindolizine), Oxamyl, Tioxazafen, Fluensulfone, Cyclobutrifluram, Burkholderia spp., Bacillus amyloliquefaciens Strain PTA-4838, Bacillus amyloliquefaciens, strain MBI 600, and Bacillus pumilus strain BU F-33. 212203-WO-SEC-1 Page 23 of 152 The term “locus” means a habitat, breeding ground, plant, seed, soil, material, or environment in which a pest is growing, may grow, or may traverse. For example, a locus may be: where crops, trees, fruits, cereals, fodder species, vines, turf, and / or ornamental plants are growing; where domesticated animals are residing; the interior or exterior surfaces of buildings 5 (such as places where grains are stored); the materials of construction used in buildings (such as impregnated wood); and the soil around buildings. In this disclosure the terms “molecule” and “compound” may be used interchangeably. The term “pest” means an organism that is detrimental to humans, or human concerns (such as, crops, food, livestock, etc.), where said organism is from Phyla Arthropoda, Mollusca, 10 or Nematoda. Particular examples are ants, aphids, bed bugs, beetles, bristletails, caterpillars, cockroaches, crickets, earwigs, fleas, flies, grasshoppers, grubs, hornets, jassids, leafhoppers, lice, locusts, maggots, mealybugs, mites, moths, nematodes, plantbugs, planthoppers, psyllids, sawflies, scales, silverfish, slugs, snails, spiders, springtails, stink bugs, symphylans, termites, thrips, ticks, wasps, whiteflies, and wireworms. 15 Additional examples are pests in (1) Subphyla Chelicerata, Myriapoda, and Hexapoda. (2) Classes of Arachnida, Symphyla, and Insecta. (3) Order Anoplura. A non–exhaustive list of particular genera includes, but is not limited to, Haematopinus spp., Hoplopleura spp., Linognathus spp., Pediculus spp., Polyplax spp., 20 Solenopotes spp., and Neohaematopinis spp. A non–exhaustive list of particular species includes, but is not limited to, Haematopinus asini, Haematopinus suis, Linognathus setosus, Linognathus ovillus, Pediculus humanus capitis, Pediculus humanus humanus, and Pthirus pubis. (4) Order Coleoptera. A non–exhaustive list of particular genera includes, but is not limited to, Acanthoscelides spp., Agriotes spp., Anthonomus spp., Apion spp., Apogonia spp., Araecerus 25 spp., Aulacophora spp., Bruchus spp., Cerosterna spp., Cerotoma spp., Ceutorhynchus spp., Chaetocnema spp., Colaspis spp., Ctenicera spp., Curculio spp., Cyclocephala spp., Diabrotica spp., Dinoderus spp., Gnathocerus spp., Hemicoelus spp., Heterobostruchus spp., Hypera spp., Ips spp., Lyctus spp., Megascelis spp., Meligethes spp., Mezium spp., Niptus spp., Otiorhynchus spp., Pantomorus spp., Phyllophaga spp., Phyllotreta spp., Ptinus spp., Rhizotrogus spp., 30 Rhynchites spp., Rhynchophorus spp., Scolytus spp., Sphenophorus spp., Sitophilus spp., Tenebrio spp., and Tribolium spp. A non–exhaustive list of particular species includes, but is not 212203-WO-SEC-1 Page 24 of 152 limited to, Acanthoscelides obtectus, Agrilus planipennis, Ahasverus advena, Alphitobius diaperinus, Anoplophora glabripennis, Anthonomus grandis, Anthrenus verbasci, Anthrenus falvipes, Ataenius spretulus, Atomaria linearis, Attagenus unicolor, Bothynoderes punctiventris, Bruchus pisorum, Callosobruchus maculatus, Carpophilus hemipterus, Cassida vittata, 5 Cathartus quadricollis, Cerotoma trifurcata, Ceutorhynchus assimilis, Ceutorhynchus napi, Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar, Cotinis nitida, Crioceris asparagi, Cryptolestes ferrugineus, Cryptolestes pusillus, Cryptolestes turcicus, Cylindrocopturus adspersus, Deporaus marginatus, Dermestes lardarius, Dermestes maculatus, Epilachna varivestis, Euvrilletta peltata, Faustinus cubae, Hylobius pales, Hylotrupes bajulus, 10 Hypera postica, Hypothenemus hampei, Lasioderma serricorne, Leptinotarsa decemlineata, Limonius canus, Liogenys fuscus, Liogenys suturalis, Lissorhoptrus oryzophilus, Lophocateres pusillus, Lyctus planicollis, Maecolaspis joliveti, Melanotus communis, Meligethes aeneus, Melolontha melolontha, Necrobia rufipes, Oberea brevis, Oberea linearis, Oryctes rhinoceros, Oryzaephilus mercator, Oryzaephilus surinamensis, Oulema melanopus, Oulema oryzae, 15 Phyllophaga cuyabana, Polycaon stoutti, Popillia japonica, Prostephanus truncatus, Rhyzopertha dominica, Sitona lineatus, Sitophilus granarius, Sitophilus oryzae, Sitophilus zeamais, Stegobium paniceum, Tenebroides mauritanicus, Tribolium castaneum, Tribolium confusum, Trogoderma granarium, Trogoderma variabile, Xestobium rufovillosum, and Zabrus tenebrioides. 20 (5) Order Dermaptera. A non–exhaustive list of particular species includes, but is not limited to, Forficula auricularia. (6) Order Blattaria. A non–exhaustive list of particular species includes, but is not limited to, Blattella germanica, Blattella asahinai, Blatta orientalis, Blatta lateralis, Parcoblatta pennsylvanica, Periplaneta americana, Periplaneta australasiae, Periplaneta brunnea, Periplaneta 25 fuliginosa, Pycnoscelus surinamensis, and Supella longipalpa. (7) Order Diptera. A non–exhaustive list of particular genera includes, but is not limited to, Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp., Bactrocera spp., Ceratitis spp., Chrysops spp., Cochliomyia spp., Contarinia spp., Culex spp., Culicoides spp., Dasineura spp., Delia spp., Drosophila spp., Fannia spp., Hylemya spp., Liriomyza spp., Musca spp., Phorbia30 spp., Pollenia spp., Psychoda spp., Simulium spp., Tabanus spp., and Tipula spp. A non– exhaustive list of particular species includes, but is not limited to, Agromyza frontella, 212203-WO-SEC-1 Page 25 of 152 Anastrepha suspensa, Anastrepha ludens, Anastrepha obliqua, Bactrocera cucurbitae, Bactrocera dorsalis, Bactrocera invadens, Bactrocera zonata, Ceratitis capitata, Dasineura brassicae, Delia platura, Fannia canicularis, Fannia scalaris, Gasterophilus intestinalis, Gracillia perseae, Haematobia irritans, Hypoderma lineatum, Liriomyza brassicae, Liriomyza 5 sativa, Melophagus ovinus, Musca autumnalis, Musca domestica, Oestrus ovis, Oscinella frit, Pegomya betae, Piophila casei, Psila rosae, Rhagoletis cerasi, Rhagoletis pomonella, Rhagoletis mendax, Sitodiplosis mosellana, and Stomoxys calcitrans. (8) Order Hemiptera. A non–exhaustive list of particular genera includes, but is not limited to, Adelges spp., Aulacaspis spp., Aphrophora spp., Aphis spp., Bemisia spp., 10 Ceroplastes spp., Chionaspis spp., Chrysomphalus spp., Coccus spp., Empoasca spp., Euschistus spp., Lepidosaphes spp., Lagynotomus spp., Lygus spp., Macrosiphum spp., Nephotettix spp., Nezara spp., Nilaparvata spp., Philaenus spp., Phytocoris spp., Piezodorus spp., Planococcus spp., Pseudococcus spp., Rhopalosiphum spp., Saissetia spp., Therioaphis spp., Toumeyella spp., Toxoptera spp., Trialeurodes spp., Triatoma spp., and Unaspis spp. A non–exhaustive list of 15 particular species includes, but is not limited to, Acrosternum hilare, Acyrthosiphon pisum, Aleyrodes proletella, Aleurodicus dispersus, Aleurothrixus floccosus, Amrasca biguttula biguttula, Aonidiella aurantii, Aphis fabae, Aphis gossypii, Aphis glycines, Aphis pomi, Aulacorthum solani, Bactericera cockerelli, Bagrada hilaris, Bemisia argentifolii, Bemisia tabaci, Blissus leucopterus, Boisea trivittata, Brachycorynella asparagi, Brevennia rehi, 20 Brevicoryne brassicae, Cacopsylla pyri, Cacopsylla pyricola, Calocoris norvegicus, Ceroplastes rubens, Cimex hemipterus, Cimex lectularius, Coccus pseudomagnoliarum, Dagbertus fasciatus, Dichelops furcatus, Diuraphis noxia, Diaphorina citri, Dysaphis plantaginea, Dysdercus suturellus, Edessa meditabunda, Empoasca vitis, Eriosoma lanigerum, Erythroneura elegantula, Eurygaster maura, Euschistus conspersus, Euschistus heros, Euschistus servus, Halyomorpha 25 halys, Helopeltis antonii, Hyalopterus pruni, Helopeltis antonii, Helopeltis theivora, Icerya purchasi, Idioscopus nitidulus, Jacobiasca formosana, Laodelphax striatellus, Lecanium corni, Leptocorisa oratorius, Leptocorisa varicornis, Lygus hesperus, Maconellicoccus hirsutus, Macrosiphum euphorbiae, Macrosiphum granarium, Macrosiphum rosae, Macrosteles quadrilineatus, Mahanarva frimbiolata, Megacopta cribraria, Metopolophium dirhodum, Mictis 30 longicornis, Myzus persicae, Nasonovia ribisnigri, Nephotettix cincticeps, Neurocolpus longirostris, Nezara viridula, Nilaparvata lugens, Paracoccus marginatus, Paratrioza cockerelli, 212203-WO-SEC-1 Page 26 of 152 Parlatoria pergandii, Parlatoria ziziphi, Peregrinus maidis, Phylloxera vitifoliae, Physokermes piceae, Phytocoris californicus, Phytocoris relativus, Piezodorus guildinii, Planococcus citri, Planococcus ficus, Poecilocapsus lineatus, Psallus vaccinicola, Pseudacysta perseae, Pseudococcus brevipes, Quadraspidiotus perniciosus, Rhopalosiphum maidis, Rhopalosiphum 5 padi, Saissetia oleae, Scaptocoris castanea, Schizaphis graminum, Sitobion avenae, Sogatella furcifera, Trialeurodes vaporariorum, Trialeurodes abutiloneus, Unaspis yanonensis, and Zulia entrerriana. (9) Order Hymenoptera. A non–exhaustive list of particular genera includes, but is not limited to, Acromyrmex spp., Atta spp., Camponotus spp., Diprion spp., Dolichovespula spp., 10 Formica spp., Monomorium spp., Neodiprion spp., Paratrechina spp., Pheidole spp., Pogonomyrmex spp., Polistes spp., Solenopsis spp., Technomyrmex, spp., Tetramorium spp., Vespula spp., Vespa spp., and Xylocopa spp. A non–exhaustive list of particular species includes, but is not limited to, Athalia rosae, Atta texana, Caliroa cerasi, Cimbex americana, Iridomyrmex humilis, Linepithema humile, Mellifera Scutellata, Monomorium minimum, Monomorium 15 pharaonis, Neodiprion sertifer, Solenopsis invicta, Solenopsis geminata, Solenopsis molesta, Solenopsis richtery, Solenopsis xyloni, Tapinoma sessile, and Wasmannia auropunctata. (10) Order Isoptera. A non–exhaustive list of particular genera includes, but is not limited to, Coptotermes spp., Cornitermes spp., Cryptotermes spp., Heterotermes spp., Kalotermes spp., Incisitermes spp., Macrotermes spp., Marginitermes spp., Microcerotermes spp., Procornitermes 20 spp., Reticulitermes spp., Schedorhinotermes spp., and Zootermopsis spp. A non–exhaustive list of particular species includes, but is not limited to, Coptotermes acinaciformis, Coptotermes curvignathus, Coptotermes frenchi, Coptotermes formosanus, Coptotermes gestroi, Cryptotermes brevis, Heterotermes aureus, Heterotermes tenuis, Incisitermes minor, Incisitermes snyderi, Microtermes obesi, Nasutitermes corniger, Odontotermes formosanus, 25 Odontotermes obesus, Reticulitermes banyulensis, Reticulitermes grassei, Reticulitermes flavipes, Reticulitermes hageni, Reticulitermes hesperus, Reticulitermes santonensis, Reticulitermes speratus, Reticulitermes tibialis, and Reticulitermes virginicus. (11) Order Lepidoptera. A non–exhaustive list of particular genera includes, but is not limited to, Adoxophyes spp., Agrotis spp., Argyrotaenia spp., Cacoecia spp., Caloptilia spp., Chilo spp., 30 Chrysodeixis spp., Colias spp., Crambus spp., Diaphania spp., Diatraea spp., Earias spp., Ephestia spp., Epimecis spp., Feltia spp., Gortyna spp., Helicoverpa spp., Heliothis spp., 212203-WO-SEC-1 Page 27 of 152 Indarbela spp., Lithocolletis spp., Loxagrotis spp., Malacosoma spp., Nemapogon spp., Peridroma spp., Phyllonorycter spp., Pseudaletia spp., Plutella spp., Sesamia spp., Spodoptera spp., Synanthedon spp., and Yponomeuta spp. A non–exhaustive list of particular species includes, but is not limited to, Achaea janata, Adoxophyes orana, Agrotis ipsilon, Alabama 5 argillacea, Amorbia cuneana, Amyelois transitella, Anacamptodes defectaria, Anarsia lineatella, Anomis sabulifera, Anticarsia gemmatalis, Archips argyrospila, Archips rosana, Argyrotaenia citrana, Autographa gamma, Bonagota cranaodes, Borbo cinnara, Bucculatrix thurberiella, Capua reticulana, Carposina niponensis, Chlumetia transversa, Choristoneura rosaceana, Cnaphalocrocis medinalis, Conopomorpha cramerella, Corcyra cephalonica, Cossus cossus, 10 Cydia caryana, Cydia funebrana, Cydia molesta, Cydia nigricana, Cydia pomonella, Darna diducta, Diaphania nitidalis, Diatraea saccharalis, Diatraea grandiosella, Earias insulana, Earias vittella, Ecdytolopha aurantianum, Elasmopalpus lignosellus, Ephestia cautella, Ephestia elutella, Ephestia kuehniella, Epinotia aporema, Epiphyas postvittana, Erionota thrax, Estigmene acrea, Eupoecilia ambiguella, Euxoa auxiliaris, Galleria mellonella, Grapholita 15 molesta, Hedylepta indicata, Helicoverpa armigera, Helicoverpa zea, Heliothis virescens, Hellula undalis, Keiferia lycopersicella, Leucinodes orbonalis, Leucoptera coffeella, Leucoptera malifoliella, Lobesia botrana, Loxagrotis albicosta, Lymantria dispar, Lyonetia clerkella, Mahasena corbetti, Mamestra brassicae, Manduca sexta, Maruca testulalis, Metisa plana, Mythimna unipuncta, Neoleucinodes elegantalis, Nymphula depunctalis, Operophtera brumata, 20 Ostrinia nubilalis, Oxydia vesulia, Pandemis cerasana, Pandemis heparana, Papilio demodocus, Pectinophora gossypiella, Peridroma saucia, Perileucoptera coffeella, Phthorimaea operculella, Phyllocnistis citrella, Phyllonorycter blancardella, Pieris rapae, Plathypena scabra, Platynota idaeusalis, Plodia interpunctella, Plutella xylostella, Polychrosis viteana, Prays endocarpa, Prays oleae, Pseudaletia unipuncta, Pseudoplusia includens, Rachiplusia nu, Scirpophaga 25 incertulas, Sesamia inferens, Sesamia nonagrioides, Setora nitens, Sitotroga cerealella, Sparganothis pilleriana, Spodoptera exigua, Spodoptera frugiperda, Spodoptera eridania, Thecla basilides, Tinea pellionella, Tineola bisselliella, Trichoplusia ni, Tuta absoluta, Zeuzera coffeae, and Zeuzea pyrina. (12) Order Mallophaga. A non–exhaustive list of particular genera includes, but is not 30 limited to, Anaticola spp., Bovicola spp., Chelopistes spp., Goniodes spp., Menacanthus spp., and Trichodectes spp. A non–exhaustive list of particular species includes, but is not limited to, 212203-WO-SEC-1 Page 28 of 152 Bovicola bovis, Bovicola caprae, Bovicola ovis, Chelopistes meleagridis, Goniodes dissimilis, Goniodes gigas, Menacanthus stramineus, Menopon gallinae, and Trichodectes canis. (13) Order Orthoptera. A non–exhaustive list of particular genera includes, but is not limited to, Melanoplus spp. and Pterophylla spp. A non–exhaustive list of particular species includes, but is 5 not limited to, Acheta domesticus, Anabrus simplex, Gryllotalpa africana, Gryllotalpa australis, Gryllotalpa brachyptera, Gryllotalpa hexadactyla, Locusta migratoria, Microcentrum retinerve, Schistocerca gregaria, and Scudderia furcata. (14) Order Psocoptera. A non–exhaustive list of particular species includes, but is not limited to, Liposcelis decolor, Liposcelis entomophila, Lachesilla quercus, and Trogium 10 pulsatorium. (15) Order Siphonaptera. A non–exhaustive list of particular species includes, but is not limited to, Ceratophyllus gallinae, Ceratophyllus niger, Ctenocephalides canis, Ctenocephalides felis, and Pulex irritans. (16) Order Thysanoptera. A non–exhaustive list of particular genera includes, but is not15 limited to, Caliothrips spp., Frankliniella spp., Scirtothrips spp., and Thrips spp. A non– exhaustive list of particular species includes, but is not limited to, Caliothrips phaseoli, Frankliniella bispinosa, Frankliniella fusca, Frankliniella occidentalis, Frankliniella schultzei, Frankliniella tritici, Frankliniella williamsi, Heliothrips haemorrhoidalis, Rhipiphorothrips cruentatus, Scirtothrips citri, Scirtothrips dorsalis, Taeniothrips rhopalantennalis, Thrips 20 hawaiiensis, Thrips nigropilosus, Thrips orientalis, Thrips palmi, and Thrips tabaci. (17) Order Thysanura. A non–exhaustive list of particular genera includes, but is not limited to, Lepisma spp. and Thermobia spp. (18) Order Acarina. A non–exhaustive list of particular genera includes, but is not limited to, Acarus spp., Aculops spp., Argus spp., Boophilus spp., Demodex spp., Dermacentor spp., 25 Epitrimerus spp., Eriophyes spp., Ixodes spp., Oligonychus spp., Panonychus spp., Rhizoglyphus spp., and Tetranychus spp. A non–exhaustive list of particular species includes, but is not limited to, Acarapis woodi, Acarus siro, Aceria mangiferae, Aculops lycopersici, Aculus pelekassi, Aculus schlechtendali, Amblyomma americanum, Brevipalpus obovatus, Brevipalpus phoenicis, Dermacentor variabilis, Dermatophagoides pteronyssinus, Eotetranychus carpini, Liponyssoides 30 sanguineus, Notoedres cati, Oligonychus coffeae, Oligonychus ilicis, Ornithonyssus bacoti, Panonychus citri, Panonychus ulmi, Phyllocoptruta oleivora, Polyphagotarsonemus latus, 212203-WO-SEC-1 Page 29 of 152 Rhipicephalus sanguineus, Sarcoptes scabiei, Tegolophus perseaflorae, Tetranychus urticae, Tyrophagus longior, and Varroa destructor. (19) Order Araneae. A non–exhaustive list of particular genera includes, but is not limited to, Loxosceles spp., Latrodectus spp., and Atrax spp. A non–exhaustive list of particular 5 species includes, but is not limited to, Loxosceles reclusa, Latrodectus mactans, and Atrax robustus. (20) Class Symphyla. A non–exhaustive list of particular species includes, but is not limited to, Scutigerella immaculata. (21) Subclass Collembola. A non–exhaustive list of particular species includes, but is not 10 limited to, Bourletiella hortensis, Onychiurus armatus, Onychiurus fimetarius, and Sminthurus viridis. (22) Phylum Nematoda. A non–exhaustive list of particular genera includes, but is not limited to, Aphelenchoides spp., Belonolaimus spp., Criconemella spp., Ditylenchus spp., Globodera spp., Heterodera spp., Hirschmanniella spp., Hoplolaimus spp., Meloidogyne spp., 15 Pratylenchus spp., and Radopholus spp. A non–exhaustive list of particular species includes, but is not limited to, Dirofilaria immitis, Globodera pallida, Heterodera glycines, Heterodera zeae, Meloidogyne incognita, Meloidogyne javanica, Onchocerca volvulus, Pratylenchus penetrans, Radopholus similis, and Rotylenchulus reniformis. (23) Phylum Mollusca. A non–exhaustive list of particular species includes, but is not 20 limited to, Arion vulgaris, Cornu aspersum, Deroceras reticulatum, Limax flavus, Milax gagates, and Pomacea canaliculata. A particularly preferred pest group to control is sap–feeding pests. Sap–feeding pests, in general, have piercing and / or sucking mouthparts and feed on the sap and inner plant tissues of plants. Examples of sap–feeding pests of particular concern to agriculture include, but are not 25 limited to, aphids, leafhoppers, moths, scales, thrips, psyllids, mealybugs, stinkbugs, and whiteflies. Specific examples of Orders that have sap–feeding pests of concern in agriculture include but are not limited to, Anoplura and Hemiptera. Specific examples of Hemiptera that are of concern in agriculture include, but are not limited to, Aulacaspis spp., Aphrophora spp., Aphis spp., Bemisia spp., Coccus spp., Euschistus spp., Lygus spp., Macrosiphum spp., Nezara spp., 30 and Rhopalosiphum spp. 212203-WO-SEC-1 Page 30 of 152 Another particularly preferred pest group to control is chewing pests. Chewing pests, in general, have mouthparts that allow them to chew on the plant tissue including roots, stems, leaves, buds, and reproductive tissues (including, but not limited to flowers, fruit, and seeds). Examples of chewing pests of particular concern to agriculture include, but are not limited to, 5 caterpillars, beetles, grasshoppers, and locusts. Specific examples of Orders that have chewing pests of concern in agriculture include but are not limited to, Coleoptera and Lepidoptera. Specific examples of Coleoptera that are of concern in agriculture include, but are not limited to, Anthonomus spp., Cerotoma spp., Chaetocnema spp., Colaspis spp., Cyclocephala spp., Diabrotica spp., Hypera spp., Phyllophaga spp., Phyllotreta spp., Sphenophorus spp., Sitophilus 10 spp. The phrase “pesticidally-effective amount” means the amount of a pesticide needed to achieve an observable effect on a pest, for example, the effects of necrosis, death, retardation, prevention, removal, destruction, or otherwise diminishing the occurrence and / or activity of a pest in a locus. This effect may come about when pest populations are repulsed from a locus, 15 pests are incapacitated in, or around, a locus, and / or pests are exterminated in, or around, a locus. Of course, a combination of these effects can occur. Generally, pest populations, activity, or both are desirably reduced more than fifty percent, preferably more than 90 percent, and most preferably more than 99 percent. In general, a pesticidally-effective amount, for agricultural purposes, is from about 0.0001 grams per hectare to about 5000 grams per hectare, preferably 20 from about 0.0001 grams per hectare to about 500 grams per hectare, and it is even more preferably from about 0.0001 grams per hectare to about 50 grams per hectare. The term “biologically-effective amount” refers to the amount of a biologically active compound (any of the compounds disclosed herein according to any aspect of the invention) sufficient to produce the desired biological effect when applied to (or contacted with) an 25 invertebrate pest to be controlled to its environment, or to a plant, the seed from which the plant is grown, or the locus of the plant (e.g., growth medium) to protect the plant from injury by the invertebrate pest or for producing another desired effect such as increasing plant vigor. All references, including publications, patent applications, and patents, referred to herein are incorporated by reference herein to the same extent as if each reference were individually and 30 specifically indicated to be incorporated by reference and were set forth in its entirety. 212203-WO-SEC-1 Page 31 of 152 The use of the terms “a” and “an” and “the” and “at least one” and similar referents in the context of this disclosure (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The use of the term “at least one” followed by a list of one or more 5 items (for example, “at least one of A and B”) is to be construed to mean one item selected from the listed items (A or B) or any combination of two or more of the listed items (A and B), unless otherwise indicated herein or clearly contradicted by context. The terms “comprising,” “having,” “including,” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely 10 intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples or exemplary language (e.g., “such as”) 15 provided herein is intended merely to better illuminate the disclosure and does not pose a limitation on the scope of the disclosure unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of any embodiment herein. DETAILED DESCRIPTION 20 This document discloses following pesticidal compositions: In an embodiment of each aspect of the invention, is a molecule of Formula (I) illustrated in Table one:

[0002] 212203-WO-SEC-1 Page 32 of 152 212203-WO-SEC-1 Page 33 of 152 212203-WO-SEC-1 Page 34 of 152 212203-WO-SEC-1 Page 35 of 152 212203-WO-SEC-1 Page 36 of 152 212203-WO-SEC-1 Page 37 of 152 212203-WO-SEC-1 Page 38 of 152 212203-WO-SEC-1 Page 39 of 152 212203-WO-SEC-1 Page 40 of 152 212203-WO-SEC-1 Page 41 of 152 212203-WO-SEC-1 Page 42 of 152 212203-WO-SEC-1 Page 43 of 152 212203-WO-SEC-1 Page 44 of 152 212203-WO-SEC-1 Page 45 of 152 212203-WO-SEC-1 Page 46 of 152 212203-WO-SEC-1 Page 47 of 152 212203-WO-SEC-1 Page 48 of 152 212203-WO-SEC-1 Page 49 of 152 212203-WO-SEC-1 Page 50 of 152 212203-WO-SEC-1 Page 51 of 152 212203-WO-SEC-1 Page 52 of 152

[0003] 212203-WO-SEC-1 Page 53 of 152 212203-WO-SEC-1 Page 54 of 152 212203-WO-SEC-1 Page 55 of 152 212203-WO-SEC-1 Page 56 of 152

[0004] 212203-WO-SEC-1 Page 57 of 152

[0005] 212203-WO-SEC-1 Page 58 of 152 212203-WO-SEC-1 Page 59 of 152 212203-WO-SEC-1 Page 60 of 152 In one embodiment, the pesticidal compositions disclosed herein comprise pesticidally- effective amounts of at least one of compounds. One embodiment of the presently-disclosed pesticidal compositions comprises pesticidally-effective amounts of a compounds selected from a group consisting of. 5 In an embodiment of the pesticidal compositions disclosed herein comprise compounds in an amount sufficient to protect an organism from a pest. “Organism” in this context can be a plant or an animal. The amount sufficient to protect an organism from a pest can be determined using any known methods in the skill of art related to agriculture or pesticides. For example, in certain instances, the amount sufficient to protect an organism from a pest can be an amount 10 sufficient to induce one or more of killing, paralysis or repelling of particular pest. It can also be an amount sufficient to get rid of pest, reduce the amount / number of pest or prevention of an infestation of a pest. In another embodiment, the pesticidal compositions disclosed herein comprise pesticidally-effective amounts of at least one of the compounds of Formula (I) in combination 15 with at least one of the active compounds selected from AIGA. In yet another embodiment, the pesticidal compositions disclosed herein comprise pesticidally-effective amounts of at least one of the compounds of Formula (I) in combination with at least one of the active compounds selected from AIGA-1. In yet another embodiment, the pesticidal compositions disclosed herein comprise 20 pesticidally-effective amounts of at least one of the compounds of Formula (I) in combination with at least one of the active compounds selected from AIGA-2. In yet another embodiment, the pesticidal compositions disclosed herein comprise pesticidally-effective amounts of at least one of the compounds of Formula (I) in combination with at least one of the active compounds selected from AIGA-3. 25 In yet another embodiment, the pesticidal compositions disclosed herein comprise pesticidally-effective amounts of at least one of the compounds of Formula (I) in combination with at least one of the active compounds selected from AIGA-4. 212203-WO-SEC-1 Page 61 of 152 In another embodiment, the pesticidal composition disclosed herein comprise pesticidally-effective amounts of at least one of compounds in combination with at least one of the active compounds selected from AIGA-1, AIGA-2, AIGA-3 and AIGA-4. Another embodiment of the presently-disclosed pesticidal compositions comprise 5 pesticidally-effective amounts of a compound selected from a group consisting of (A) and at least one of the compounds selected from AIGA, AIGA-1, AIGA-2, AIGA-3 or AIGA-4 (B). In some other embodiments, the pesticidal compositions disclosed herein comprise pesticidally-effective amounts of at least one of the compounds (A) and one of the active agents selected from AIGA, AIGA-1, AIGA-2, AIGA-3 or AIGA-4 (B) at a weight ratio of: 10 (1) 10000:1 to 1:10000; (2) 1000:1 to 1:1000; (3) 500:1 to 1:500; (4) 100:1 to 1:100; (5) 50:1 to 1:50; 15 (6) 20:1 to 1:20; (7) 10:1 to 1:10; (8) 5:1 to 1:5; (9) 3:1 to 1:3; (10) 2:1 to 1:2; or 20 (11) 1:1. In some other embodiments, the pesticidal composition disclosed herein comprise pesticidally-effective amounts of at least one of the compounds) (A) and one of the active agents selected from AIGA, AIGA-1, AIGA-2, AIGA-3 or AIGA-4 (B) at a weight ratio of: 25 (1) 10000:1 to 1:10000; (2) 1000:1 to 1:1000; (3) 500:1 to 1:500; (4) 100:1 to 1:100; (5) 50:1 to 1:50; 30 (6) 20:1 to 1:20; (7) 10:1 to 1:10; 212203-WO-SEC-1 Page 62 of 152 (8) 5:1 to 1:5; (9) 3:1 to 1:3; (10) 2:1 to 1:2; or (11) 1:1. 5 The following details are additionally provided: d1. A molecule of Formula I: Formula I wherein; 10 A) X is selected from the group consisting of -H and (C1-C6) alkyl; B) R1is -H or -CH3; C) R2is -H or -F; D) R3is selected from the group consisting of -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2- CH3, -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O-CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2- 15 CHCl2, -CH2-O-CHF2, -CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3; 212203-WO-SEC-1 Page 63 of 152 E) R4is selected from the group consisting of -H, -CH3and when R4is -O, a fused ring comprising the following structure: F) R5 is selected from the group consisting of -CH3, -OCH3, -N(CH3)2, and a fused ring comprising the 5 following structure when R4is -O: wherein 10 A) R6is -H or -F; B) R7 is selected from the group consisting of -Cl, -CF3, -OCF3, CN, -SF5, and -SCF3; and C) R8is -H or -F; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula I. 212203-WO-SEC-1 Page 64 of 152 d2. A molecule according to d1, having Formula II: Formula II 5 wherein, A) R1is -H or -CH3; B) R2 is H or F; C) X is selected from the group consisting of -H, -CH3, and -CH2CH3; F) R3is -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2-CH3, -CH2-O-CH3, - 10 CH(CH3)2, -CH2-O-CH2-CF2Cl, -OCH2CH2CF3,-CH2-O-CH2-CF2-CH3, and -CH2-O-CH2-CHCl2; G) R4is selected from the group consisting of -H, -CH3or when R7is O, a fused ring having the following structure: 212203-WO-SEC-1 Page 65 of 152 H) R5is selected from the group consisting of -CH3, -N(CH3)2, -OCH3, and a fused ring having the following structure when R7is O: I) R6 is -F or -H; 5 J) R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula II.

[0006] 212203-WO-SEC-1 Page 66 of 152 d3. A molecule according to according to d1, having Formula III: Formula III 5 wherein, D) R1-H or -CH3; E) R2is -H or -F; F) R3is selected from the group consisting of -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -O-CH2-CH2- CF3, -CH2-O-CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, - 10 CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3; B) R4is selected from the group consisting of -H, -CH3and when R2is -O, a fused ring comprising the following structure: C) R5is selected from the group consisting of -CH3, -OCH3, -N(CH3)2, and a fused ring comprising the 15 following structure when R2is -O: 212203-WO-SEC-1 Page 67 of 152 , where, 5 R6is H or F; R7is selected from the group consisting of -Cl, -CF3, -OCF3, CN, -SF5, and -SCF3; and R8is H or F; E) X is selected from the group consisting of -H, -CH3, and -CH2CH3;and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula III. 10 d4. A molecule of d1, having Formula IV:

[0007] 212203-WO-SEC-1 Page 68 of 152 Formula IV 5 wherein, A) R1is -H or -CH3; B) R2is H or F; C) X is selected from the group consisting of -H, -CH3, and -CH2CH3; 10 F) R3is -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2-CH3, -CH2-O-CH3, - CH(CH3)2, -CH2-O-CH2-CF2Cl, -OCH2CH2CF3,-CH2-O-CH2-CF2-CH3, and -CH2-O-CH2-CHCl2; G) R4is selected from the group consisting of -H, -CH3or when R7is O, a fused ring having the following structure: 212203-WO-SEC-1 Page 69 of 152 H) R5is selected from the group consisting of -CH3, -N(CH3)2, -OCH3, and a fused ring having the following structure when R7is O: I) R6 is -F or -H; 5 J) R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula II. d5. The molecule of d4, wherein R6is H. d6. The molecule according to d1-d5, wherein R2is F. d7. The molecule according to d1-d6, wherein R1is -H. 10 d8. The molecule according to d1-d6, wherein R1is -CH3. d9. The molecule according d1-d8, wherein X is -H. d10. The molecule according to d1-d8, wherein X is -CH3. d11. The molecule according to d1-d8, wherein X is -CH2CH3. d12. The molecule according to d2, wherein: 15 R2is F; 212203-WO-SEC-1 Page 70 of 152 and R3is selected from the group consisting of -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O- CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, - CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3.d13. The molecule according to d1, selected from the group consisting of formula V and formula VI: 5 Formula VI 10 wherein; R2is F; R3is selected from the group consisting of -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O-CH2- CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, -CH2-O- CH3, -CH(CH3)2, and -CH2-CH2-CH3; 212203-WO-SEC-1 Page 71 of 152 R6is -F or -H; and R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN. d14. The molecule according to d13, wherein in formula V and formula VI: R1is H, X is selected from the group consisting of H, -CH3, and -CH2CH3. 5 d15. The molecule according to d14, wherein in formula V and formula VI: R1is -CH3, X is selected from the group consisting of H, -CH3, and -CH2CH3. d16. A composition comprising a molecule of d1-d15, wherein the molecule is selected from the group consisting of F1, F2, F3, F4, F5, F6, F7, F8, F9, F10, F11, F12, F13, F14, F15, F16, F17, F18, F19, F20, F21, F22, F23, F24, F25, F26, F27, F28, F29, F30, F31, F32, 10 F33, F34, F35, F36, F37, F38, F39, F40, F41, F42, F43, F44, F45, F46, F47, F48, F49, F50, F51, F52, F53, F54, F55, F56, F57, F58, F59, F60, F61, F62, F63, F64, F65, F66, F67, F68, F69, F70, F71, F72, F73, F74, F75, F76, F77, F78, F79, F80, F81, F82, F83, F84, F85, and F86.. d17. A composition comprising a molecule according to d1-d16, comprising at least one 15 additional active compound selected from the group consisting of Abamectin, Acephate, Acequinocyl, Acrinathrin, Acynonapyr, Afidopyropen, Alanycarb, Aldicarb, Allethrin, alpha-Cypermethrin, Amitraz, Azadirachtin, Azamethiphos, Azinphos-ethyl, Azinphos- methyl, Azocyclotin, Azoxystrobin, Bacillus amyloliquefaciens PTA4838, Bacillus amyloliquefaciens MBI 600, Bendiocarb, Benfuracarb, Bensultap, Benzoximate, 20 Benzpyrimoxan, beta-Cyfluthrin, beta-Cypermethrin, Bifenazate, Bifenthrin, Bioallethrin, Bioresmethrin, Bistrifluron, Broflanilide, Bromopropylate, Buprofezin, Butocarboxim, Butoxycarboxim, Cadusafos, Carbaryl, Carbofuran, Carbosulfan, Cartap hydrochloride, Chinomethionat, Chlorantraniliprole, Chlordane, Chlorethoxyfos, Chlorfenapyr, Chlorfenvinphos, Chlorfluazuron, Chlormephos, Chlorpyrifos, 25 Chlorpyrifos-methyl, Chromafenozide, Clofentezine, Clothianidin, Coumaphos, 212203-WO-SEC-1 Page 72 of 152 Cyanophos, Cyantraniliprole, Cyclaniliprole, Cyclobutrifluram, Cycloprothrin, Cyenopyrafen, Cyflumetofen, Cyfluthrin, beta-Cyfluthrin, Cyhalothrin, gamma- Cyhalothrin, lambda-Cyhalothrin, Cyhexatin, Cypermethrin, Cyphenothrin, Cyromazine, d-cis-trans Allethrin, DDVP, Deltamethrin, Demeton-S-methyl, Diafenthiuron, Diazinon, 5 Dichlorvos, Dicofol, Dicrotophos, Diflovidazin, Diflubenzuron, Dimethoate, Dimethylvinphos, Disulfoton, DNOC, d-trans Allethrin, Emamectin benzoate, Empenthrin, Endosulfan, EPN, Esfenvalerate, Ethaboxam, Ethiofencarb, Ethion, Ethiprole, Ethoprophos, Etofenprox, Famphur, Fenamiphos, Fenazaquin, Fenbutatin oxide, Fenitrothion, Fenobucarb, Fenoxycarb, Fenpropathrin, Fenpyroximate, Fenthion, 10 Fenvalerate, Fipronil, Flonicamid, Fluacrypyrim, Flubendiamide, Flucycloxuron, Flucythrinate, Fludioxonil, Flufenoxuron, Flumethrin, Flupyradifurone, Fluopyram, Fluoxastrobin, Flupyradifurone, Fluxametamide, Formetanate, Fosthiazate, Furathiocarb, gamma-Cyhalothrin, Halfenprox, Halofenozide, Heptenophos, Hexaflumuron, Hexythiazox, Hydramethylnon, Hydroprene, Imicyafos, Imidacloprid, Imiprothrin, 15 Indiflin, Indoxacarb, Inpyrfluxam, Ipconazole, Isocycloseram, Isofenphos, Isoprocarb, Isoxathion, Kadethrin, Kinoprene, lambda-Cyhalothrin, Lepimectin, Lufenuron, Malathion, Mancozeb, Mecarbam, Metaflumizone, Metalaxyl, Metalaxyl-M, Methamidophos, Methidathion, Methiocarb, Methomyl, Methoprene, Methoxychlor, Methoxyfenozide, Metolcarb, Mevinphos, Milbemectin, Monocrotophos, Naled, 20 Novaluron, Noviflumuron, Omethoate, Oxamyl, Oxathiapiprolin, Oxydemeton-methyl, Parathion, Parathion-methyl, Penicillium bilaiae, Penflufen, Permethrin, Phenothrin, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Picoxystrobin, Pirimicarb, Pirimiphos-methyl, Prallethrin, Profenofos, Propargite, Propetamphos, Propoxur, Prothioconazole, Prothiofos, Pydiflumetofen, Pyflubumide, Pymetrozine, 25 Pyraclofos, Pyrethrum, Pyridaben, Pyridalyl, Pyridaphenthion, Pyrifluquinazon, Pyrimidifen, Pyriproxyfen, Quinalphos, Resmethrin, Rotenone, Sedaxane, Silafluofen, Spidoxamat, Spinetoram, Spinosad, Spirodiclofen, Spiromesifen, Spiropidion, Spirotetramat, Sulfluramid, Sulfotep, Sulfoxaflor, tau-Fluvalinate, Tebufenozide, Tebufenpyrad, Tebupirimfos, Teflubenzuron, Tefluthrin, Temephos, Terbufos, 30 Tetrachlorvinphos, Tetradifon, Tetramethrin, Tetraniliprole, theta-cypermethrin, Thiabendazole, Thiocyclam, Thiodicarb, Thiofanox, Thiomethoxam, Thiometon, 212203-WO-SEC-1 Page 73 of 152 Thiosultap-sodium, Tolfenpyrad, Tralomethrin, Transfluthrin, Triazamate, Triazophos, Trichlorfon, Triflumezopyrim, Triflumuron, Trimethacarb, Vamidothion, XMC, Xylylcarb, zeta-Cypermethrin, Bacillus thuringiensis delta endotoxins, entomopathogenic bacteria, entomopathogenic viruses and entomopathogenic fungi. 5 d18. The composition of d17 wherein the molecule according to d1-d16 is present in biologically-effective amount to protect an organism from an invertebrate parasitic pest. d19. The composition of d18 wherein the organism is a plant. d20. The composition of d18 wherein the organism is an animal. d21. The composition of d20 in a form of oral administration formulation. 10 d22. The composition of d16-d19 further comprising a liquid fertilizer. d23. A method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically-effective amount of a compound of any of claims d1-d17. d24. A treated seed comprising a molecule according to the d1-d17 in an amount from about 15 0.0001 to 2% by weight of the seed before treatment.

[0008] 212203-WO-SEC-1 Page 74 of 152 d25. A molecule selected from any one of F1, F2, F3, F4, F5, F6, F7, F8, F9, F10, F11, F12, F13, F14, F15, F16, F17, F18, F19, F20, F21, F22, F23, F24, F25, F26, F27, F28, F29, F30, F31, F32, F33, F34, F35, F36, F37, F38, F39, F40, F41, F42, F43, F44, F45, F46, F47, F48, F49, F50, F51, F52, F53, F54, F55, F56, F57, F58, F59, F60, F61, F62, F63, F64, F65, F66, F67, F68, F69, F70, F71, F72, F73, F74, 5 F75, F76, F77, F78, F79, F80, F81, F82, F83, F84, F85 and F86; and compound (B), wherein compound B is selected from Penflufen, Prothioconazole, Metalaxyl, Imidacloprid, Pydiflumetofen, Ethaboxam, Mefonoxam, Spinosad, Bacillus amyloliquefaciens MBI 600, Bacillus amyloliquefaciens PTA4838, Tefluthrin, Lamda or gamma cyhalothrin, Fluopyram;Bacillus strain MBI 600, Ipconazole, Clothianidin, Thiamethoxam, Picoxystrobin, 10 Flupyradifurone, Penicillium bilaiae; Cyclobutrifluram, Inpyrfluxam, Fludioxonil, Azoxystrobin;Oxathiapiprolin, Sedaxane, Difenoconazole, Thiabendazole, Tebuconazole, Pydiflumetofen, Fipronil, Fluoxastrobin, Sluxapyroxad, Trifloxystrobin, Thiram, Fluoxapiprolin, Isoflucypram, Metconazole, Picarbutrazox, Mefentriluconazole, Fluazaindolizine, Abamectin, Burkholderi spp., Brofanilide, Cyclaniliprole, Flupyrimin, Isocycloseram, Chlorantraniliprole, 15 Cyantraniliprole and Tetraniliprole. d25. The mixture according to d17 or d24, wherein the molecule and compound (B) present in a ratio selected from 1:10 to 10:1, 1:20 to 20:1; 1:30 to 30:1; 1:40 to 40:1; 1:50 to 50:1; 1:60 to 60:1; 1:70 to 70:1; 1:80 to 80:1; 1:90 to 90:1; 1:100 to 100:1 and 1:125 to 125:1. d26. A composition comprising a molecule selected from the group consisting of C1, C2, C3, 20 C4, C5, C6, C7, C8, C9, C10, C11, C12, C13, C14, C15, C16, C17, C18, C19, C20, and C21. d28. A process comprising the step of using a molecule selected from the group consisting of C1, C2, C3, C4, C5, C6, C7, C8, C9, C10, C11, C12, C13, C14, C15, C16, C17, C18, C19, C20, 212203-WO-SEC-1 Page 75 of 152 and C21, wherein the molecule is utilized in any step of the process..Agriculturally acceptable acid addition salts, salt derivatives, solvates, ester derivatives, polymorphs, isotopes, and radionuclides Any of the molecules disclosed herein, including the molecules of Formula (I), may be 5 formulated into agriculturally acceptable acid addition salts. By way of a non–limiting example, an amine function can form salts with hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, benzoic, citric, malonic, salicylic, malic, fumaric, oxalic, succinic, tartaric, lactic, gluconic, ascorbic, maleic, aspartic, benzenesulfonic, methanesulfonic, ethanesulfonic, hydroxymethanesulfonic, and hydroxyethanesulfonic acids. Additionally, by way of a non– 10 limiting example, an acid function can form salts including those derived from alkali or alkaline earth metals and those derived from ammonia and amines. Examples of preferred cations include sodium, potassium, and magnesium. Any of the molecules disclosed herein may be formulated into salt derivatives. By way of a non–limiting example, a salt derivative may be prepared by contacting a free base with a 15 sufficient amount of the desired acid to produce a salt. A free base may be regenerated by treating the salt with a suitable dilute aqueous base solution such as dilute aqueous sodium hydroxide, potassium carbonate, ammonia, and sodium bicarbonate. As an example, in many cases, a pesticide, such as 2,4–D, is made more water–soluble by converting it to its dimethylamine salt. 20 Any of the molecules disclosed herein may be formulated into stable complexes with a solvent, such that the complex remains intact after the non–complexed solvent is removed. These complexes are often referred to as "solvates.” However, it is particularly desirable to form stable hydrates with water as the solvent. Molecules disclosed herein containing an acid functionality may be made into ester 25 derivatives. These ester derivatives can then be applied in the same manner as the molecules disclosed in this document are applied. Any of the molecules disclosed herein may be made as various crystal polymorphs. Polymorphism is important in the development of agrochemicals since different crystal polymorphs or structures of the same molecule can have vastly different physical properties and 30 biological performances. 212203-WO-SEC-1 Page 76 of 152 Any of the molecules disclosed herein may be made with different isotopes. Of particular importance are molecules having2H (also known as deuterium) or in place of1H. Molecules of Formula (I) may be made with different radionuclides. Of particular importance are molecules having14C (also known as radiocarbon) or molecules having3H (also known as tritium). 5 Molecules of Formula (I) having deuterium, tritium, or14C may be used in biological studies allowing tracing in chemical and physiological processes and half–life studies, as well as mode of action studies. Formulations 10 A pesticide may not be suitable for application in its pure form. It is usually necessary to add other substances so that the pesticide may be used at the required concentration and in an appropriate form, permitting ease of application, handling, transportation, storage, and maximum pesticide activity. Thus, pesticides are formulated into, for example, baits, concentrated emulsions, dusts, emulsifiable concentrates, fumigants, gels, granules, microencapsulations, seed 15 treatments, suspension concentrates, suspoemulsions, tablets, water soluble liquids, water dispersible granules or dry flowables, wettable powders, and ultra–low volume solutions. Pesticides are applied most often as aqueous suspensions or emulsions prepared from concentrated formulations of such pesticides. Such water–soluble, water–suspendable, or emulsifiable formulations are either solids, usually known as wettable powders, water dispersible 20 granules, liquids usually known as emulsifiable concentrates, or aqueous suspensions. Wettable powders, which may be compacted to form water dispersible granules, comprise an intimate mixture of the pesticide, a carrier, and surfactants. The concentration of the pesticide is usually from about 10% to about 90% by weight. The carrier is usually selected from among the attapulgite clays, the montmorillonite clays, the diatomaceous earths, or the purified silicates. 25 Effective surfactants, comprising from about 0.5% to about 10% of the wettable powder, are found among sulfonated lignins, condensed naphthalenesulfonates, naphthalenesulfonates, alkylbenzenesulfonates, alkyl sulfates, and non–ionic surfactants such as ethylene oxide adducts of alkyl phenols. Emulsifiable concentrates of pesticides comprise a convenient concentration of a 30 pesticide, such as from about 50 to about 500 grams per liter of liquid dissolved in a carrier that is either a water miscible solvent or a mixture of water–immiscible organic solvent and 212203-WO-SEC-1 Page 77 of 152 emulsifiers. Useful organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high–boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such 5 as 2–ethoxyethanol. Suitable emulsifiers for emulsifiable concentrates are selected from conventional anionic and non–ionic surfactants. Aqueous suspensions comprise suspensions of water–insoluble pesticides dispersed in an aqueous carrier at a concentration in the range from about 5% to about 50% by weight. Suspensions are prepared by finely grinding the pesticide and vigorously mixing it into a carrier 10 comprised of water and surfactants. Ingredients, such as inorganic salts and synthetic or natural gums may, also be added to increase the density and viscosity of the aqueous carrier. It is often most effective to grind and mix the pesticide at the same time by preparing the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or piston–type homogenizer. The pesticide in suspension might be microencapsulated in plastic polymer. 15 Oil dispersions (OD) comprise suspensions of organic solvent–insoluble pesticides finely dispersed in a mixture of organic solvent and emulsifiers at a concentration in the range from about 2% to about 50% by weight. One or more pesticide might be dissolved in the organic solvent. Useful organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high–boiling naphthalenic and olefinic portions of petroleum such as heavy 20 aromatic naphtha. Other solvents may include vegetable oils, seed oils, and esters of vegetable and seed oils. Suitable emulsifiers for oil dispersions are selected from conventional anionic and non–ionic surfactants. Thickeners or gelling agents are added in the formulation of oil dispersions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. 25 Pesticides may also be applied as granular compositions that are particularly useful for applications to the soil. Granular compositions usually contain from about 0.5% to about 10% by weight of the pesticide, dispersed in a carrier that comprises clay or a similar substance. Such compositions are usually prepared by dissolving the pesticide in a suitable solvent and applying it to a granular carrier, which has been pre–formed to the appropriate particle size, in the range of 30 from about 0.5 mm to about 3 mm. Such compositions may also be formulated by making a dough or paste of the carrier and molecule, and then crushing and drying to obtain the desired 212203-WO-SEC-1 Page 78 of 152 granular particle size. Another form of granules is a water emulsifiable granule (EG). It is a formulation consisting of granules to be applied as a conventional oil–in–water emulsion of the active ingredient(s), either solubilized or diluted in an organic solvent, after disintegration and dissolution in water. Water emulsifiable granules comprise one or several active ingredient(s), 5 either solubilized or diluted in a suitable organic solvent that is (are) absorbed in a water-soluble polymeric shell or some other type of soluble or insoluble matrix. Dusts containing a pesticide are prepared by intimately mixing the pesticide in powdered form with a suitable dusty agricultural carrier, such as kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1% to about 10% of the pesticide. Dusts may be 10 applied as a seed dressing or as a foliage application with a dust blower machine. It is equally practical to apply a pesticide in the form of a solution in an appropriate organic solvent, usually petroleum oil, such as the spray oils, which are widely used in agricultural chemistry. Pesticides can also be applied in the form of an aerosol composition. In such 15 compositions, the pesticide is dissolved or dispersed in a carrier, which is a pressure–generating propellant mixture. The aerosol composition is packaged in a container from which the mixture is dispensed through an atomizing valve. Pesticide baits are formed when the pesticide is mixed with food or an attractant or both. When the pests eat the bait, they also consume the pesticide. Baits may take the form of granules, 20 gels, flowable powders, liquids, or solids. Baits may be used in pest harborages. Fumigants are pesticides that have a relatively high vapor pressure and hence can exist as a gas in sufficient concentrations to kill pests in soil or enclosed spaces. The toxicity of the fumigant is proportional to its concentration and the exposure time. They are characterized by a good capacity for diffusion and act by penetrating the pest’s respiratory system or being 25 absorbed through the pest’s cuticle. Fumigants are applied to control stored product pests under gas proof sheets, in gas sealed rooms or buildings, or in special chambers. Pesticides may be microencapsulated by suspending the pesticide particles or droplets in plastic polymers of various types. By altering the chemistry of the polymer or by changing factors in the processing, microcapsules may be formed of various sizes, solubility, wall 30 thicknesses, and degrees of penetrability. These factors govern the speed with which the active ingredient within is released, which in turn, affects the residual performance, speed of action, and 212203-WO-SEC-1 Page 79 of 152 odor of the product. The microcapsules might be formulated as suspension concentrates or water dispersible granules. Oil solution concentrates are made by dissolving pesticide in a solvent that will hold the pesticide in solution. Oil solutions of a pesticide usually provide faster knockdown and kill of 5 pests than other formulations due to the solvents themselves having pesticidal action and the dissolution of the waxy covering of the integument increasing the speed of uptake of the pesticide. Other advantages of oil solutions include better storage stability, better penetration of crevices, and better adhesion to greasy surfaces. Another embodiment is an oil–in–water emulsion, wherein the emulsion comprises oily 10 globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase, wherein each oily globule comprises at least one molecule which is agriculturally active, and is individually coated with a monolamellar or oligolamellar layer comprising: (1) at least one non–ionic lipophilic surface–active agent, (2) at least one non–ionic hydrophilic surface–active agent, and (3) at least one ionic surface–active agent, wherein the globules having 15 a mean particle diameter of less than 800 nanometers. Other Formulation Components Generally, when the molecules disclosed herein are used in a formulation, such formulation can also contain other components. These components include, but are not limited 20 to, (this is a non–exhaustive and non–mutually exclusive list) wetters, spreaders, stickers, penetrants, buffers, sequestering agents, drift reduction agents, compatibility agents, anti–foam agents, cleaning agents, and emulsifiers. A few components are described forthwith. A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on 25 which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank to reduce the wetting time of wettable powders and to improve the penetration of water into water–dispersible granules. Examples of wetting agents 30 used in wettable powder, suspension concentrate, and water–dispersible granule formulations 212203-WO-SEC-1 Page 80 of 152 are: sodium lauryl sulfate, sodium dioctyl sulfosuccinate, alkyl phenol ethoxylates, and aliphatic alcohol ethoxylates. A dispersing agent is a substance that adsorbs onto the surface of particles, helps to preserve the state of dispersion of the particles, and prevents them from reaggregating. 5 Dispersing agents are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles redisperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates, and water–dispersible granules. Surfactants that are used as dispersing agents have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to reaggregation of particles. The most commonly 10 used surfactants are anionic, non–ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersing agents are sodium lignosulfonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium–naphthalene–sulfonate–formaldehyde–condensates. Tristyrylphenol ethoxylate phosphate esters are also used. Non–ionics such as alkylarylethylene oxide condensates and EO– 15 PO block copolymers are sometimes combined with anionics as dispersing agents for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersing agents. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long–term stability to suspension concentrates 20 because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersing agents used in agrochemical formulations are: sodium lignosulfonates, sodium naphthalene sulfonate formaldehyde condensates, tristyrylphenol–ethoxylate–phosphate– esters, aliphatic alcohol ethoxylates, alkyl ethoxylates, EO–PO block copolymers, and graft copolymers. 25 An emulsifying agent is a substance that stabilizes a suspension of droplets of one liquid phase in another liquid phase. Without the emulsifying agent, the two liquids would separate into two immiscible liquid phases. The most commonly used emulsifier blends contain an alkylphenol or an aliphatic alcohol with twelve or more ethylene oxide units and the oil–soluble calcium salt of dodecylbenzenesulfonic acid. A range of hydrophile–lipophile balance (“HLB”) 30 values from about 8 to about 18 will normally provide good, stable emulsions. Emulsion stability 212203-WO-SEC-1 Page 81 of 152 can sometimes be improved by the addition of a small amount of an EO–PO block copolymer surfactant. A solubilizing agent is a surfactant that will form micelles in water at concentrations above the critical micelle concentration. The micelles are then able to dissolve or solubilize 5 water–insoluble materials inside the hydrophobic part of the micelle. The types of surfactants usually used for solubilization are non–ionics, sorbitan monooleates, sorbitan monooleate ethoxylates, and methyl oleate esters. Surfactants are sometimes used, either alone or with other additives such as mineral or vegetable oils as adjuvants to spray–tank mixes to improve the biological performance of the 10 pesticide on the target. The types of surfactants used for bioenhancement depend generally on the nature and mode of action of the pesticide. However, they are often non–ionics such as: alkyl ethoxylates, linear aliphatic alcohol ethoxylates, and aliphatic amine ethoxylates. A carrier or diluent in an agricultural formulation is a material added to the pesticide to give a product of the required strength. Carriers are usually materials with high absorptive 15 capacities, while diluents are usually materials with low absorptive capacities. Carriers and diluents are used in the formulation of dusts, wettable powders, granules, and water–dispersible granules. Organic solvents are used mainly in the formulation of emulsifiable concentrates, oil–in– water emulsions, suspoemulsions, oil dispersions, and ultra–low volume formulations, and to a 20 lesser extent, granular formulations. Sometimes mixtures of solvents are used. The first main groups of solvents are aliphatic paraffinic oils such as kerosene or refined paraffins. The second main group (and the most common) comprises the aromatic solvents such as xylene and higher molecular weight fractions of C9 and C10 aromatic solvents. Chlorinated hydrocarbons are useful as cosolvents to prevent crystallization of pesticides when the formulation is emulsified 25 into water. Alcohols are sometimes used as cosolvents to increase solvent power. Other solvents may include vegetable oils, seed oils, and esters of vegetable and seed oils. Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, oil dispersions, emulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or 30 droplets. Thickening, gelling, and anti–settling agents generally fall into two categories, namely water–insoluble particulates and water–soluble polymers. It is possible to produce suspension 212203-WO-SEC-1 Page 82 of 152 concentrate and oil dispersion formulations using clays and silicas. Examples of these types of materials, include, but are not limited to, montmorillonite, bentonite, magnesium aluminum silicate, and attapulgite. Water–soluble polysaccharides in water-based suspension concentrates have been used as thickening–gelling agents for many years. The types of polysaccharides most 5 commonly used are natural extracts of seeds and seaweeds or are synthetic derivatives of cellulose. Examples of these types of materials include, but are not limited to, guar gum, locust bean gum, carrageenam, alginates, methyl cellulose, sodium carboxymethyl cellulose (SCMC), and hydroxyethyl cellulose (HEC). Other types of anti–settling agents are based on modified starches, polyacrylates, polyvinyl alcohol, and polyethylene oxide. Another good anti–settling 10 agent is xanthan gum. Microorganisms can cause spoilage of formulated products. Therefore, preservation agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt, sorbic acid and its sodium or potassium salts, benzoic acid and its sodium salt, p–hydroxybenzoic acid sodium salt, methyl p– 15 hydroxybenzoate, and 1,2–benzisothiazolin–3–one (BIT). The presence of surfactants often causes water–based formulations to foam during mixing operations in production and in application through a spray tank. In order to reduce the tendency to foam, anti–foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti–foam agents, namely silicones and20 non–silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane, while the non– silicone anti–foam agents are water–insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti–foam agent is to displace the surfactant from the air–water interface. “Green” agents (e.g., adjuvants, surfactants, solvents) can reduce the overall 25 environmental footprint of crop protection formulations. Green agents are biodegradable and generally derived from natural and / or sustainable sources, e.g. plant and animal sources. Specific examples are: vegetable oils, seed oils, and esters thereof, also alkoxylated alkyl polyglucosides. Applications 30 Molecules disclosed herein may be applied to any locus. Particular loci to apply such molecules include loci where alfalfa, almonds, apples, barley, beans, canola, corn, cotton, 212203-WO-SEC-1 Page 83 of 152 crucifers, flowers, fodder species (Rye Grass, Sudan Grass, Tall Fescue, Kentucky Blue Grass, and Clover), fruits, lettuce, oats, oil seed crops, oranges, peanuts, pears, peppers, potatoes, rice, sorghum, soybeans, strawberries, sugarcane, sugarbeets, sunflowers, tobacco, tomatoes, wheat (for example, Hard Red Winter Wheat, Soft Red Winter Wheat, White Winter Wheat, Hard Red 5 Spring Wheat, and Durum Spring Wheat), and other valuable crops are growing or the seeds thereof are going to be planted. Molecules disclosed herein may also be applied where plants, such as crops, are growing and where there are low levels (even no actual presence) of pests that can commercially damage such plants. Applying such molecules in such locus is to benefit the plants being grown in such 10 locus. Such benefits, may include, but are not limited to: helping the plant grow a better root system; helping the plant better withstand stressful growing conditions; improving the health of a plant; improving the yield of a plant (e.g. increased biomass and / or increased content of valuable ingredients); improving the vigor of a plant (e.g. improved plant growth and / or greener leaves); improving the quality of a plant (e.g. improved content or composition of certain ingredients); 15 and improving the tolerance to abiotic and / or biotic stress of the plant. Molecules disclosed herein may be applied with ammonium sulfate when growing various plants as this may provide additional benefits. Molecules disclosed herein may be applied on, in, or around plants genetically modified to express specialized traits, such as Bacillus thuringiensis (for example, Cry1Ab, Cry1Ac, 20 Cry1Fa, Cry1A.105, Cry2Ab, Vip3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1 / Cry35Ab1), other insecticidal toxins, or those expressing herbicide tolerance, or those with “stacked” foreign genes expressing insecticidal toxins, herbicide tolerance, nutrition–enhancement, or any other beneficial traits. Molecules disclosed herein may be applied to the foliar and / or fruiting portions of plants 25 to control pests. Either such molecules will come in direct contact with the pest, or the pest will consume such molecules when eating the plant or while extracting sap or other nutrients from the plant. Molecules disclosed herein may also be applied to the soil, and when applied in this manner, root and stem feeding pests may be controlled. The roots may absorb such molecules 30 thereby taking it up into the foliar portions of the plant to control above ground chewing and sap feeding pests. 212203-WO-SEC-1 Page 84 of 152 Systemic movement of pesticides in plants may be utilized to control pests on one portion of the plant by applying (for example by spraying a locus) molecules disclosed herein to a different portion of the plant. For example, control of foliar–feeding insects may be achieved by drip irrigation or furrow application, by treating the soil with for example pre– or post–planting 5 soil drench, or by treating the seeds of a plant before planting. Molecules disclosed herein may be used with baits. Generally, with baits, the baits are placed in the ground where, for example, termites can come into contact with, and / or be attracted to, the bait. Baits can also be applied to a surface of a building, (horizontal, vertical, or slant surface) where, for example, ants, termites, cockroaches, and flies, can come into contact with, 10 and / or be attracted to, the bait. Molecules disclosed herein may be encapsulated inside or placed on the surface of a capsule. The size of the capsules can range from nanometer size (about 100–900 nanometers in diameter) to micrometer size (about 10–900 microns in diameter). Molecules disclosed herein may be applied to eggs of pests. Because of the unique ability 15 of the eggs of some pests to resist certain pesticides, repeated applications of such molecules may be desirable to control newly emerged larvae. Molecules disclosed herein may be applied as seed treatments. Seed treatments may be applied to all types of seeds, including those from which plants genetically modified to express specialized traits will germinate. Representative examples include those expressing proteins 20 toxic to invertebrate pests, such as Bacillus thuringiensis or other insecticidal toxins, those expressing herbicide tolerance, such as “Roundup Ready” seed, or those with “stacked” foreign genes expressing insecticidal toxins, herbicide tolerance, nutrition–enhancement, drought tolerance, or any other beneficial traits. Furthermore, such seed treatments with molecules of Formula (I) may further enhance the ability of a plant to withstand stressful growing conditions 25 better. This results in a healthier, more vigorous plant, which can lead to higher yields at harvest time. Generally, about 1 gram of such molecules to about 500 grams per 100,000 seeds is expected to provide good benefits, amounts from about 10 grams to about 100 grams per 100,000 seeds is expected to provide better benefits, and amounts from about 25 grams to about 75 grams per 100,000 seeds is expected to provide even better benefits. 30 Molecules disclosed herein may be applied with one or more active ingredients in a soil amendment. 212203-WO-SEC-1 Page 85 of 152 Molecules disclosed herein may be used for controlling endoparasites and ectoparasites in the veterinary medicine sector or in the field of non–human–animal keeping. Such molecules may be applied by oral administration in the form of, for example, tablets, capsules, drinks, granules, by dermal application in the form of, for example, dipping, spraying, pouring on, 5 spotting on, and dusting, and by parenteral administration in the form of, for example, an injection. Molecules disclosed herein may also be employed advantageously in livestock keeping, for example, cattle, chickens, geese, goats, pigs, sheep, and turkeys. They may also be employed advantageously in pets such as, horses, dogs, and cats. Particular pests to control would be flies, 10 fleas, and ticks that are bothersome to such animals. Suitable formulations are administered orally to the animals with the drinking water or feed. The dosages and formulations that are suitable depend on the species. Molecules disclosed herein may also be used for controlling parasitic worms, especially of the intestine, in the animals listed above. 15 Molecules disclosed herein may also be employed in therapeutic methods for human health care. Such methods include, but are limited to, oral administration in the form of, for example, tablets, capsules, drinks, granules, and by dermal application. Molecules disclosed herein may also be applied to invasive pests. Pests around the world have been migrating to new environments (for such pests) and thereafter becoming a new invasive species in 20 such new environment. Such molecules may also be used on such new invasive species to control them in such new environments.

[0009] 212203-WO-SEC-1 Page 86 of 152 EXPERIMENTAL SECTION General Synthetic Procedures: The compounds F1-F86 can be prepared via the following general procedures: 5 Scheme 1 The compounds of formula I can be prepared according to the following general procedures: 212203-WO-SEC-1 Page 87 of 152 Scheme 2 Substituted thiazolidines of formula A2 can be prepared by procedures disclosed in US94696171B2 and WO2021011722A1, which have been fully-incorporated by reference herein in their entirety. 212203-WO-SEC-1 Page 88 of 152 212203-WO-SEC-1 Page 89 of 152 212203-WO-SEC-1 Page 90 of 152 212203-WO-SEC-1 Page 91 of 152 212203-WO-SEC-1 Page 92 of 152 Representative procedure for the synthesis of pyrazole halides C1-C3: C1: To a solution of 3-(4-nitrophenyl)-3-oxopropanenitrile (1.00 g, 5.26 mmol) and hydrazine hydrate (0.465 ml, 5.26 mmol) in ethanol (22.32 ml) was added p-toluenesulfonic acid monohydrate (0.100 g, 0.526 mmol). The reaction was allowed to stir at 80°C for 3h, then allowed to stir at r.t. overnight. 5 After stirring overnight, LCMS indicated reaction completion. The reaction was diluted with water (20 mL) and transferred to a separatory funnel with the aid of EtOAc (20 mL). The layers were separated, and the aq. layer was extracted with EtOAc (20 mL). The combined organic layers were washed with sat. aq. sodium bicarbonate (30 mL) and brine (30 mL), dried with sodium / magnesium sulfate, and concentrated in vacuo. The residual solid was taken up in the minimal amount of hot EtOAc, and heptanes were added, 10 causing a solid to precipitate out. This solid was collected by vacuum filtration to afford the desired product as an off-white solid. C2: 5-(4-nitrophenyl)-1H-pyrazol-3-amine (810 mg, 3.97 mmol) and 3-fluoro-4- (trifluoromethoxy)benzoic acid (889 mg, 3.97 mmol) were taken up in ethyl acetate (19.8 mL), and to the resulting cloudy orange suspension were sequentially added pyridine (642 µl, 7.93 mmol) and 2,4,6- 15 tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (5195 µl, 8.73 mmol). The reaction slowly became orange and clear. The reaction was allowed to stir at room temperature for 1h, at which time LCMS indicated reaction completion. The EtOAc was removed in vacuo, and the residue was taken up in water (30 mL), causing an orange solid to precipitate out. This solid was collected by vacuum filtration, then was immediately re-suspended in water (30 mL) and stirred vigorously for 30 minutes, at which time 20 it was collected by vacuum filtration. The collected solid was further purified by normal phase flash chromatography (0-5% MeOH: DCM) to afford the desired product as a yellow solid. C3: 3-fluoro-N-(5-(4-nitrophenyl)-1H-pyrazol-3-yl)-4-(trifluoromethoxy)benzamide (777 mg, 1.894 mmol) was taken up in ethanol (15.2 mL) and Water (3.79 mL), and to the resulting suspension were added ammonium chloride (405 mg, 7.58 mmol) and iron (423 mg, 7.58 mmol). The reaction was 25 allowed to stir at 80°C for 2h, at which time the reaction was allowed to cool to r.t., was diluted with 212203-WO-SEC-1 Page 93 of 152 EtOAc (20 mL) and filtered over a pad of celite, washing with water (10 mL) and EtOAc (10 mL). The biphasic filtrate was transferred to a separatory funnel. The layers were separated, and the aq. layer was extracted with EtOAc (30 mL). The combined organic layers were washed with brine (50 mL), dried over sodium / magnesium sulfate, and concentrated in vacuo. The residue was recrystallized from heptanes to 5 afford the desired product, which required no further purification. Representative procedure for the synthesis of pyrazole halides C4-C9: Amide coupling of pyrazole amine and substituted benzoic acids: To a suspension of 3,5-difluoro-4-(trifluoromethyl)benzoic acid (1.00 g, 4.42 mmol) and 5-bromo-1H- pyrazol-3-amine (0.716 g, 4.42 mmol) in ethyl acetate (11.06 ml) were added pyridine (0.715 ml, 8.85 10 mmol) and 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (5.79 ml, 9.73 mmol). The reaction was allowed to stir at ambient temperature for 2h, at which time LCMS indicated reaction completion. The EtOAc was then removed in vacuo, and the residue was diluted with water (30 mL), causing a solid to precipitate out. This solid was collected by vacuum filtration, and was re-suspended in water (30 mL) and allowed to stir vigorously for 30 minutes. The solid was once again collected by 15 vacuum filtration, washed with water (10 mL) and heptanes (20 mL), then dried under high vacuum to afford the desired product (C5) as a light grey solid. Representative procedure of the synthesis of pyrazole halides C10-C15: N-Methylation of pyrazole halides Procedure 1: To a solution of N-(5-bromo-1H-pyrazol-3-yl)-3,5-difluoro-4-(trifluoromethyl)benzamide 20 (1.06 g, 2.86 mmol) (C5) in DMF (7.16 ml) were added potassium carbonate (1.188 g, 8.59 mmol) and methyl iodide (0.716 ml, 11.46 mmol) dropwise at ambient temperature. The reaction was allowed to stir at ambient temperature for 5h, at which time LCMS indicated complete conversion. The reaction was diluted with water (20 mL), but no solid readily precipitated out. The reaction mixture was diluted with EtOAc (50 mL) and was transferred to a separatory funnel. The layers were separated, and the aq. layer 25 was extracted with EtOAc (20 mL). The combined organic layers were washed with 1N HCl (30 mL) followed by brine (30 mL), dried over sodium / magnesium sulfate, and concentrated in vacuo. The residue was purified by normal phase flash chromatography (0-50% EtOAc : Hexanes) to afford the desired product (C10) as an off-white solid. Procedure 2: To a solution of N-(5-bromo-1H-pyrazol-3-yl)-5-(trifluoromethoxy)picolinamide (1.37 g, 30 3.90 mmol) (C6) in DMF (9.76 ml) were added potassium carbonate (1.618 g, 11.71 mmol) and methyl 212203-WO-SEC-1 Page 94 of 152 iodide (0.976 ml, 15.61 mmol) dropwise at ambient temperature. The reaction was allowed to stir at ambient temperature for 5h, at which time LCMS indicated full consumption of the starting material. The reaction was quenched by the addition of water (20 mL), causing a solid to precipitate out. This solid was collected by vacuum filtration and washed with water (10 mL) and hexanes (20 mL). It was then purified 5 by normal phase flash chromatography (0-50% EtOAc : Hexanes) to afford the desired product (C11) as a white solid. Representative procedure of the synthesis of pyrazole benzylamines C16-C21: Suzuki coupling Procedure 1: N-(3-bromo-1-methyl-1H-pyrazol-5-yl)-3,5-difluoro-N-methyl-4-10 (trifluoromethyl)benzamide (165 mg, 0.414 mmol) (C10), 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)aniline (108 mg, 0.456 mmol), Xphos Pd G3 (17.52 mg, 0.021 mmol) and tripotassium phosphate (264 mg, 1.243 mmol) were combined in a 40 mL vial and taken up in dioxane (1.87 mL) and water (0.207 mL). The reaction was allowed to stir at 90°C for 16h, at which time LCMS indicated full consumption of the starting material. After cooling to room temperature, the reaction was diluted with 15 EtOAc (20 mL) and water (20 mL) and the biphasic mixture was transferred to a separatory funnel. The layers were separated, and the aq. layer was extracted with EtOAc (2 x 20 mL). The combined organic layers were washed with sat. aq. sodium bicarbonate (50 mL), followed by brine (50 mL), dried over sodium / magnesium sulfate, and concentrated in vacuo. The residue was purified by normal phase flash chromatography (0-30% EtOAc : Hexanes) to afford the desired product (C16) as a green solid. 20 Procedure 2: Tetrakis(triphenylphosphine)palladium (0) (102 mg, 0.089 mmol), N-(3-bromo-1-methyl- 1H-pyrazol-5-yl)-5-(trifluoromethoxy)picolinamide (C11) (323.2 mg, 0.885 mmol), 2-fluoro-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (231 mg, 0.974 mmol) and sodium hydrogen carbonate (223 mg, 2.66 mmol) were combined in a microwave vial and suspended in dioxane (3187 µl) and water (354 µl). The reaction was allowed to proceed at 150°C for 30 minutes under microwave irradiation. LCMS 25 indicated product formation. The reaction mixture was diluted with EtOAc (10 mL) and water (5 mL), and transferred to a separatory funnel. The layers were separated, and the aq. layer was extracted with EtOAc (2 x 10 mL). The combined organic layers were washed with sat. aq. sodium bicarbonate (20 mL) and brine (20 mL), dried over sodium / magnesium sulfate, and concentrated in vacuo. The residue was purified by normal phase flash chromatography (0-50% EtOAc : Hexanes) to afford the desired product 30 as a pale yellow solid (C18). Procedure for the synthesis of C1: To a solution of 3-(4-nitrophenyl)-3-oxopropanenitrile (1.00 g, 5.26 mmol) and hydrazine hydrate (0.465 ml, 5.26 mmol) in ethanol (22.32 ml) was added p- 212203-WO-SEC-1 Page 95 of 152 toluenesulfonic acid monohydrate (0.100 g, 0.526 mmol). The reaction was allowed to stir at 80°C for 3h, then allowed to stir at r.t. overnight. After stirring overnight, LCMS indicated reaction completion. The reaction was diluted with water (20 mL) and transferred to a separatory funnel with the aid of EtOAc (20 mL). The layers were separated, and 5 the aq. layer was extracted with EtOAc (20 mL). The combined organic layers were washed with sat. aq. sodium bicarbonate (30 mL) and brine (30 mL), dried with sodium / magnesium sulfate, and concentrated in vacuo. The residual solid was taken up in the minimal amount of hot EtOAc, and heptanes were added, causing a solid to precipitate out. This solid was collected by vacuum filtration to afford the desired product as an off-white solid 10 Representative procedure for the synthesis of pyrazoles F1-F86: Procedure 1: N-(5-(4-aminophenyl)-1H-pyrazol-3-yl)-3-fluoro-4-(trifluoromethoxy)benzamide (50 mg, 0.131 mmol) (C3) was dissolved in THF (1 mL), and 4-nitrophenyl carbonochloridate (26.5 mg, 0.131 mmol) was added, causing the reaction to become cloudy. The reaction was allowed to stir at room temperature overnight. After 22h, 2-imino-3-(5-methyl-2-((2,2,2- 15 trifluoroethoxy)methyl)phenyl)thiazolidin-4-one (41.9 mg, 0.131 mmol) was added. followed by DIPEA (0.069 mL, 0.394 mmol), at which point the reaction became clear. After stirring for an additional 40 minutes, the THF was removed over a stream of nitrogen. The residue was taken up in DCM (5 mL) and transferred to a separatory funnel, where it was washed with 20% aq. potassium carbonate (2x5 mL). The organic layer was then passed through a phase separator and concentrated under a stream of nitrogen. The 20 residue was dissolved in the minimal amount of EtOAc, and heptanes were added, causing a solid to precipitate out. The solids were collected by vacuum filtration, washing with hexanes, and were dried over high vacuum. The residue was purified by normal phase flash chromatography (0-40% EtOAc : Hexanes) to afford the desired compound (F55) as a yellow foam. Procedure 2: N-(5-(4-aminophenyl)-1H-pyrazol-3-yl)-3-fluoro-4-(trifluoromethoxy)benzamide (50 mg, 25 0.131 mmol) (C3) was dissolved in THF (1 mL), and 4-nitrophenyl carbonochloridate (26.5 mg, 0.131 mmol) was added, causing the reaction to become cloudy. The reaction was allowed to stir at room temperature overnight. After 22h, 3-(2-((2,2-difluoroethoxy)methyl)-5-methylphenyl)-2-iminothiazolidin- 4-one (39.5 mg, 0.131 mmol) was added. followed by DIPEA (0.069 mL, 0.394 mmol), at which point the reaction became clear. After stirring for an additional 40 minutes, the THF was removed over a stream 30 of nitrogen. The residue was purified by normal phase flash chromatography (0-50% EtOAc : Hexanes) to afford the desired product (F56) an orange foam . 212203-WO-SEC-1 Page 96 of 152 Procedure 3: To a stirred solution of N-(3-(4-amino-3-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)-3,5- difluoro-N-methyl-4-(trifluoromethyl)benzamide (31.6 mg, 0.074 mmol) (C16) in THF (0.5 mL) in a 1 dram vial was added 4-nitrophenyl carbonochloridate (14.87 mg, 0.074 mmol). The reaction was allowed to stir overnight. After stirring overnight, 2-imino-3-(5-methyl-2-((2,2,2- 5 trifluoroethoxy)methyl)phenyl)thiazolidin-4-one (23.48 mg, 0.074 mmol) was added, followed by DIPEA (0.039 mL, 0.221 mmol). The reaction was allowed to proceed at r.t. for 1 h, at which time LCMS indicated product formation. The solvent was removed with a stream of N2, and the residue was taken up in DCM (5 mL) and transferred to a separatory funnel, where it was washed with 20% aq. potassium carbonate (2 x 5 mL). The organic layer was then passed through a phase separator, and evaporated under 10 a stream of N2. The residue was dissolved in the minimal amount of EtOAc, and heptanes was added, causing a solid to precipitate out. The solid was collected by vacuum filtration and washed with hexanes to afford the desired product (F20) pink solid.

[0010] 212203-WO-SEC-1 Page 97 of 152 Analytical Data – Compounds F1-F86: 212203-WO-SEC-1 Page 98 of 152 212203-WO-SEC-1 Page 99 of 152 212203-WO-SEC-1 Page 100 of 152 212203-WO-SEC-1 Page 101 of 152 212203-WO-SEC-1 Page 102 of 152

[0011] 212203-WO-SEC-1 Page 103 of 152 212203-WO-SEC-1 Page 104 of 152 212203-WO-SEC-1 Page 105 of 152 212203-WO-SEC-1 Page 106 of 152 212203-WO-SEC-1 Page 107 of 152 212203-WO-SEC-1 Page 108 of 152 212203-WO-SEC-1 Page 109 of 152 212203-WO-SEC-1 Page 110 of 152 212203-WO-SEC-1 Page 111 of 152 212203-WO-SEC-1 Page 112 of 152 212203-WO-SEC-1 Page 113 of 152 212203-WO-SEC-1 Page 114 of 152 212203-WO-SEC-1 Page 115 of 152 212203-WO-SEC-1 Page 116 of 152 212203-WO-SEC-1 Page 117 of 152 212203-WO-SEC-1 Page 118 of 152

[0012] 212203-WO-SEC-1 Page 119 of 152 212203-WO-SEC-1 Page 120 of 152 212203-WO-SEC-1 Page 121 of 152

[0013] 212203-WO-SEC-1 Page 122 of 152 212203-WO-SEC-1 Page 123 of 152 212203-WO-SEC-1 Page 124 of 152

[0014] 212203-WO-SEC-1 Page 125 of 152 212203-WO-SEC-1 Page 126 of 152 Analytical data – Compounds C1-C21: 212203-WO-SEC-1 Page 127 of 152 212203-WO-SEC-1 Page 128 of 152 212203-WO-SEC-1 Page 129 of 152 212203-WO-SEC-1 Page 130 of 152

[0015] 212203-WO-SEC-1 Page 131 of 152 Biological Assay Procedures Insecticidal test for beet armyworm (Spodoptera exigua, LAPHEG, “BAW”) Beet armyworm (BAW; Spodoptera exigua: Lepidoptera) is a serious pest of economic 5 concern for alfalfa, asparagus, beets, citrus, corn, cotton, onions, peas, peppers, potatoes, soybeans, sugar beets, sunflowers, tobacco, and tomatoes, among other crops. It is native to Southeast Asia but is now found in Africa, Australia, Japan, North America, and Southern Europe. The larvae may feed in large swarms, causing devastating crop losses. It is known to be resistant to several pesticides. 10 Bioassays on BAW were conducted using a 128-well diet tray assay. One to five second instar BAW larvae were placed in each well (3 milliliters (mL)) of the diet tray that had been previously filled with 1 mL of artificial diet to which 50 micrograms per square centimeter (µg / cm2) of the test compound (dissolved in 50 microliters (µL) of 90:10 acetone–water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a 15 clear self-adhesive cover, vented to allow gas exchange, and held at 25 °C, 14:10 light–dark for five to seven days. Percent mortality was recorded for the larvae in each well; activity in the eight wells was then averaged. Insecticidal test for cabbage looper (Trichloplusia ni, TRIPNI, “CL”) Cabbage looper (CL; Trichloplusia ni: Lepidoptera) is a serious pest found throughout 20 the world. It attacks alfalfa, beans, beets, broccoli, Brussel sprouts, cabbage, cantaloupe, cauliflower, celery, collards, cotton, cucumbers, eggplant, kale, lettuce, melons, mustard, parsley, peas, peppers, potatoes, soybeans, spinach, squash, tomatoes, turnips, and watermelons, among other crops. This species is very destructive to plants due to its voracious appetite. The larvae consume three times their weight in food daily. The feeding sites are marked by large 25 accumulations of sticky, wet, fecal material, which may contribute to higher disease pressure, thereby causing secondary problems on the plants in the site. It is known to be resistant to several pesticides. Bioassays on CL were conducted using a 128-well diet tray assay. One to five second instar CL larvae were placed in each well (3 mL) of the diet tray that had been previously filled 30 with 1 mL of artificial diet to which 50 µg / cm2of the test compound (dissolved in 50 µL of 212203-WO-SEC-1 Page 132 of 152 90:10 acetone–water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a clear self-adhesive cover, vented to allow gas exchange, and held at 25 °C, 14:10 light–dark for five to seven days. Percent mortality was recorded for the larvae in each well; activity in the eight wells is then averaged. 5 Consequently, because of the above factors, control of these pests is important. Furthermore, molecules that control these pests (BAW and CL), which are known as chewing pests, will be useful in controlling other pests that chew on plants. In the reporting of the results, the “BAW & CL Rating Table” was used (See Table Section). Insecticidal test for green peach aphid (Myzus persicae, MYZUPE) (“GPA”) 10 Green peach aphid (GPA; Myzus persicae: Hemiptera) is the most significant aphid pest of peach trees, causing decreased growth, shriveling of the leaves, and the death of various tissues. It is also hazardous because it acts as a vector for the transport of plant viruses, such as potato virus Y and potato leafroll virus, to members of the nightshade / potato family Solanaceae, and various mosaic viruses to many other food crops. GPA attacks such plants as broccoli, 15 burdock, cabbage, carrot, cauliflower, daikon, eggplant, green beans, lettuce, macadamia, papaya, peppers, sweet potatoes, tomatoes, watercress, and zucchini, among other crops. GPA also attacks many ornamental crops such as carnation, chrysanthemum, flowering white cabbage, poinsettia, and roses. GPA has developed resistance to many pesticides. Currently, this pest has the third largest number of reported cases of insect resistance (Sparks et al.). Consequently, 20 because of the above factors control of this pest is important. Furthermore, molecules that control this pest (GPA), which is known as a sap–feeding pest, are useful in controlling other pests that feed on the sap from plants. Certain molecules disclosed in this document were tested against GPA using procedures described in the following example. In the reporting of the results, the “GPA & YFM Rating 25 Table” was used (See Table Section). Cabbage seedlings grown in 3–inch pots, with 2–3 small (3–5 cm) true leaves, were used as test substrate. The seedlings were infested with 20–50 GPA (wingless adult and nymph stages) one day prior to chemical application. Four pots with individual seedlings were used for each treatment. Test molecules (2 milligrams (mg)) were dissolved in 2 mL of acetone / methanol 30 (1:1) solvent, forming stock solutions of 1000 parts per million (ppm) test molecule. The stock solutions were diluted 5X with 0.025% Tween 20 in water to obtain the solution at 200 ppm test 212203-WO-SEC-1 Page 133 of 152 molecule. A hand–held aspirator–type sprayer was used for spraying a solution to both sides of cabbage leaves until runoff. Reference plants (solvent check) were sprayed with the diluent only containing 20% by volume of acetone / methanol (1:1) solvent. Treated plants were held in a holding room for three days at approximately 25 °C and ambient relative humidity (RH) prior to 5 grading. Evaluation was conducted by counting the number of live aphids per plant under a microscope. Percent control was measured using Abbott’s correction formula (W. S. Abbott, “A Method of Computing the Effectiveness of an Insecticide” J. Econ. Entomol.18 (1925), pp.265– 267) as follows. Corrected % Control = 100 * (X – Y) / X where X = No. of live aphids on solvent check plants and Y = No. of live aphids on treated plants. The results are indicated in the 10 table entitled “Table ABC: Biological Results” (See Table Section). Insecticidal test for yellow fever mosquito (Aedes aegypti, AEDSAE) (“YFM”) The yellow fever mosquito (YFM; Aedes aegypti: Diptera) prefers to feed on humans during the daytime and is most frequently found in or near human habitations. YFM is a vector for transmitting several diseases. It is a mosquito that can spread the dengue fever and yellow 15 fever viruses. Yellow fever is the second most dangerous mosquito–borne disease after malaria. Yellow fever is an acute viral hemorrhagic disease and up to 50% of severely affected persons without treatment will die from yellow fever. There are an estimated 200,000 cases of yellow fever, causing 30,000 deaths worldwide each year. Dengue fever is a nasty, viral disease; it is sometimes called "breakbone fever" or "break–heart fever" because of the intense pain it can 20 produce. Dengue fever kills about 20,000 people annually. Master plates containing 400 µg of a compound dissolved in 100 µL of dimethyl sulfoxide (DMSO) (equivalent to a 4000 ppm solution) were used. A master plate of assembled compounds contained 15 µL per well. To this plate, 135 µL of a 90:10 water / acetone mixture was added to each well. A robot (Biomek® NXP Laboratory Automation Workstation) was 25 programmed to dispense 15 µL aspirations from the master plate into an empty 96–well shallow plate (“daughter” plate). There were 6 reps (“daughter” plates) created per master. The created “daughter” plates were then immediately infested with YFM larvae. The day before plates were to be treated, mosquito eggs were placed in Millipore water containing liver powder to begin hatching (4 grams (g). into 400 mL). After the “daughter” 30 plates were created using the robot, they were infested with 220 µL of the liver powder / larval mosquito mixture (about 1 day–old larvae). After plates were infested with mosquito larvae, a 212203-WO-SEC-1 Page 134 of 152 non–evaporative lid was used to cover the plate to reduce drying. Plates were held at room temperature for 3 days prior to grading. After 3 days, each well was observed and scored based on mortality. Consequently, because of the above factors, control of this pest is important. 5 Furthermore, molecules that control this pest (YFM), which is known as a sucking pest, are useful in controlling other pests that cause human and non-human animal suffering. In the reporting of the results, the “GPA & YFM Rating Table” was used (See Table Section). BAW & CL Rating Table 10 GPA & YFM Rating Table Biological data for compounds in Table one 212203-WO-SEC-1 Page 135 of 152 212203-WO-SEC-1 Page 136 of 152 212203-WO-SEC-1 Page 137 of 152 212203-WO-SEC-1 Page 138 of 152 212203-WO-SEC-1 Page 139 of 152

Claims

212203-WO-SEC-1 Page 140 of 152 CLAIMS:

1. A molecule of Formula I:5 Formula I wherein; A) X is selected from the group consisting of -H and (C1-C6) alkyl; B) R1is -H or -CH3; C) R2is -H or -F; 10 D) R3is selected from the group consisting of -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2- CH3, -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O-CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2- CHCl2, -CH2-O-CHF2, -CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3; E) R4is selected from the group consisting of -H, -CH3and when R4is -O, a fused ring comprising the following structure:212203-WO-SEC-1 Page 141 of 152F) R5is selected from the group consisting of -CH3, -OCH3, -N(CH3)2, and a fused ring comprising the following structure when R4is -O: 5 Gwherein A) R6is -H or -F; B) R7is selected from the group consisting of -Cl, -CF3, -OCF3, CN, -SF5, and -SCF3;and 10 C) R8is -H or -F; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula I.

2. A molecule according to claim 1, having Formula II:212203-WO-SEC-1 Page 142 of 152Formula II wherein, A) R1is -H or -CH3; 5 B) R2is H or F; C) X is selected from the group consisting of -H, -CH3, and -CH2CH3; F) R3 is -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2-CH3, -CH2-O-CH3, - CH(CH3)2, -CH2-O-CH2-CF2Cl, -OCH2CH2CF3,-CH2-O-CH2-CF2-CH3, and -CH2-O-CH2-CHCl2; G) R4is selected from the group consisting of -H, -CH3or when R7is O, a fused ring having the following 10 structure:H) R5is selected from the group consisting of -CH3, -N(CH3)2, -OCH3, and a fused ring having the following structure when R7is O:212203-WO-SEC-1 Page 143 of 152I) R6 is -F or -H; J) R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula II. 5212203-WO-SEC-1 Page 144 of 152 3. A molecule according to according to claim 1, having Formula III:Formula III 5 wherein, G) R1-H or -CH3; H) R2is -H or -F; I) R3is selected from the group consisting of -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -O-CH2-CH2- CF3, -CH2-O-CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, - 10 CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3; B) R4is selected from the group consisting of -H, -CH3and when R2is -O, a fused ring comprising the following structure:C) R5is selected from the group consisting of -CH3, -OCH3, -N(CH3)2, and a fused ring comprising the 15 following structure when R2is -O:212203-WO-SEC-1 Page 145 of 152, where, 5 R6is H or F; R7is selected from the group consisting of -Cl, -CF3, -OCF3, CN, -SF5, and -SCF3; and R8is H or F; E) X is selected from the group consisting of -H, -CH3, and -CH2CH3;and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula III. 10 4. A molecule of claim 1, having Formula IV:212203-WO-SEC-1 Page 146 of 152Formula IV 5 wherein, A) R1is -H or -CH3; B) R2is H or F; C) X is selected from the group consisting of -H, -CH3, and -CH2CH3; 10 F) R3is -CH2-O-CH2-CF3, -CH2-O-CH2-CHF2, -CH2-O-CH2-CH2F, -CH2-O-CH2-CH3, -CH2-O-CH3, - CH(CH3)2, -CH2-O-CH2-CF2Cl, -OCH2CH2CF3,-CH2-O-CH2-CF2-CH3, and -CH2-O-CH2-CHCl2; G) R4is selected from the group consisting of -H, -CH3or when R7is O, a fused ring having the following structure:212203-WO-SEC-1 Page 147 of 152 H) R5is selected from the group consisting of -CH3, -N(CH3)2, -OCH3, and a fused ring having the following structure when R7is O:I) R6 is -F or -H; 5 J) R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN; and resolved stereoisomers, salts, polymorphs and hydrates of the molecules of Formula II.

5. The molecule of claim 4, wherein R6is H.

6. The molecule according to claims 1-5, wherein R2is F.

7. The molecule according to claims 1-6, wherein R1is -H. 10 8. The molecule according to claims 1-6, wherein R1is -CH3.

9. The molecule according claims 1-8, wherein X is -H.

10. The molecule according to claims 1-8, wherein X is -CH3.

11. The molecule according to claims 1-8, wherein X is -CH2CH3.

12. The molecule according to claim 2, wherein: 15 R2is F;212203-WO-SEC-1 Page 148 of 152 and R3is selected from the group consisting of -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O- CH2-CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, - CH2-O-CH3, -CH(CH3)2, and -CH2-CH2-CH3.

13. The molecule according to claim 1, selected from the group consisting of formula V and formula 5 VI:Formula VI 10 wherein; R2is F;212203-WO-SEC-1 Page 149 of 152 R3is selected from the group consisting of -CH2-O-CH2-CF3, -O-CH2-CH2-CF3, -CH2-O-CH2- CF2-CH3, -CH2-O-CH2-CF2Cl, -CH2-O-CH2-CF3, -CH2-O-CH2-CHCl2, -CH2-O-CHF2, -CH2-O- CH3, -CH(CH3)2, and -CH2-CH2-CH3;R6is -F or -H; and 5 R7is selected from the group consisting of -OCF3, -CF3, -Cl, and -CN.

14. The molecule according to claim 13, wherein in formula V and formula VI: R1is H, X is selected from the group consisting of H, -CH3, and -CH2CH3.

15. The molecule according to claim 14, wherein in formula V and formula VI: R1is -CH3, X is selected from the group consisting of H, -CH3, and -CH2CH3. 10 16. A composition comprising a molecule of claims 1-15, wherein the molecule is selected from the group consisting of molecules F1-F86.

17. A composition comprising a molecule according to claims 1-15, comprising at least one additional active compound selected from the group consisting of Abamectin, Acephate, Acequinocyl, Acrinathrin, Acynonapyr, Afidopyropen, Alanycarb, Aldicarb, Allethrin,15 alpha-Cypermethrin, Amitraz, Azadirachtin, Azamethiphos, Azinphos-ethyl, Azinphos- methyl, Azocyclotin, Azoxystrobin, Bacillus amyloliquefaciens PTA4838, Bacillus amyloliquefaciens MBI 600, Bendiocarb, Benfuracarb, Bensultap, Benzoximate, Benzpyrimoxan, beta-Cyfluthrin, beta-Cypermethrin, Bifenazate, Bifenthrin, Bioallethrin, Bioresmethrin, Bistrifluron, Broflanilide, Bromopropylate, Buprofezin, 20 Butocarboxim, Butoxycarboxim, Cadusafos, Carbaryl, Carbofuran, Carbosulfan, Cartap hydrochloride, Chinomethionat, Chlorantraniliprole, Chlordane, Chlorethoxyfos, Chlorfenapyr, Chlorfenvinphos, Chlorfluazuron, Chlormephos, Chlorpyrifos, Chlorpyrifos-methyl, Chromafenozide, Clofentezine, Clothianidin, Coumaphos, Cyanophos, Cyantraniliprole, Cyclaniliprole, Cyclobutrifluram, Cycloprothrin,212203-WO-SEC-1 Page 150 of 152 Cyenopyrafen, Cyflumetofen, Cyfluthrin, beta-Cyfluthrin, Cyhalothrin, gamma- Cyhalothrin, lambda-Cyhalothrin, Cyhexatin, Cypermethrin, Cyphenothrin, Cyromazine, d-cis-trans Allethrin, DDVP, Deltamethrin, Demeton-S-methyl, Diafenthiuron, Diazinon, Dichlorvos, Dicofol, Dicrotophos, Diflovidazin, Diflubenzuron, Dimethoate, 5 Dimethylvinphos, Disulfoton, DNOC, d-trans Allethrin, Emamectin benzoate, Empenthrin, Endosulfan, EPN, Esfenvalerate, Ethaboxam, Ethiofencarb, Ethion, Ethiprole, Ethoprophos, Etofenprox, Famphur, Fenamiphos, Fenazaquin, Fenbutatin oxide, Fenitrothion, Fenobucarb, Fenoxycarb, Fenpropathrin, Fenpyroximate, Fenthion, Fenvalerate, Fipronil, Flonicamid, Fluacrypyrim, Flubendiamide, Flucycloxuron, 10 Flucythrinate, Fludioxonil, Flufenoxuron, Flumethrin, Flupyradifurone, Fluopyram, Fluoxastrobin, Flupyradifurone, Fluxametamide, Formetanate, Fosthiazate, Furathiocarb, gamma-Cyhalothrin, Halfenprox, Halofenozide, Heptenophos, Hexaflumuron, Hexythiazox, Hydramethylnon, Hydroprene, Imicyafos, Imidacloprid, Imiprothrin, Indiflin, Indoxacarb, Inpyrfluxam, Ipconazole, Isocycloseram, Isofenphos, Isoprocarb, 15 Isoxathion, Kadethrin, Kinoprene, lambda-Cyhalothrin, Lepimectin, Lufenuron, Malathion, Mancozeb, Mecarbam, Metaflumizone, Metalaxyl, Metalaxyl-M, Methamidophos, Methidathion, Methiocarb, Methomyl, Methoprene, Methoxychlor, Methoxyfenozide, Metolcarb, Mevinphos, Milbemectin, Monocrotophos, Naled, Novaluron, Noviflumuron, Omethoate, Oxamyl, Oxathiapiprolin, Oxydemeton-methyl, 20 Parathion, Parathion-methyl, Penicillium bilaiae, Penflufen, Permethrin, Phenothrin, Phenthoate, Phorate, Phosalone, Phosmet, Phosphamidon, Phoxim, Picoxystrobin, Pirimicarb, Pirimiphos-methyl, Prallethrin, Profenofos, Propargite, Propetamphos, Propoxur, Prothioconazole, Prothiofos, Pydiflumetofen, Pyflubumide, Pymetrozine, Pyraclofos, Pyrethrum, Pyridaben, Pyridalyl, Pyridaphenthion, Pyrifluquinazon, 25 Pyrimidifen, Pyriproxyfen, Quinalphos, Resmethrin, Rotenone, Sedaxane, Silafluofen, Spidoxamat, Spinetoram, Spinosad, Spirodiclofen, Spiromesifen, Spiropidion, Spirotetramat, Sulfluramid, Sulfotep, Sulfoxaflor, tau-Fluvalinate, Tebufenozide, Tebufenpyrad, Tebupirimfos, Teflubenzuron, Tefluthrin, Temephos, Terbufos, Tetrachlorvinphos, Tetradifon, Tetramethrin, Tetraniliprole, theta-cypermethrin, 30 Thiabendazole, Thiocyclam, Thiodicarb, Thiofanox, Thiomethoxam, Thiometon, Thiosultap-sodium, Tolfenpyrad, Tralomethrin, Transfluthrin, Triazamate, Triazophos,212203-WO-SEC-1 Page 151 of 152 Trichlorfon, Triflumezopyrim, Triflumuron, Trimethacarb, Vamidothion, XMC, Xylylcarb, zeta-Cypermethrin, Bacillus thuringiensis delta endotoxins, entomopathogenic bacteria, entomopathogenic viruses and entomopathogenic fungi.

18. The composition of claim 17 wherein the molecule according to claims 1-17 is present in 5 biologically-effective amount to protect an organism from an invertebrate parasitic pest.

19. The composition of claim 18 wherein the organism is a plant.

20. A method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically-effective amount of a compound of any of claims 1-17. 10 21. A treated seed comprising a molecule according to the claims 1-17 in an amount from about 0.0001 to 2% by weight of the seed before treatment.

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