Method for screening therapeutic agent for demyelination-related diseases

WO2025244441A1PCT designated stage Publication Date: 2025-11-27ENCELL CO LTD +1
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Patent Information

Application Number
PCT/KR2025/006978
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-05-23
Filing Date
2025-05-22
Publication Date
2025-11-27

AI Technical Summary

Technical Problem

Current treatments for demyelinating diseases, such as Charcot-Marie-Tooth disease, primarily focus on symptom alleviation and lack effective therapeutic options due to the rare nature of the disease and limited research, with no established treatments for genetic abnormalities causing progressive symptoms.

Method used

A novel screening system involving a first screening to measure Schwann cell proliferation and a second screening to assess differentiation and remyelination potential of candidate substances, using Schwann cell models to identify therapeutic agents promoting Schwann cell proliferation and differentiation.

Benefits of technology

The method enables the identification of therapeutic agents that effectively promote Schwann cell proliferation and remyelination, providing a mechanism for treating demyelinating diseases by enhancing Schwann cell function and myelination.

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Abstract

The present invention relates to a method for screening a therapeutic agent for demyelination-related diseases by performing a first screening and a second screening, wherein the first screening comprises the steps of: (1-1) treating Schwann cells with a candidate material; and (1-2) measuring a proliferation index level of Schwann cells in cells treated with the candidate material, and the second screening comprises the steps of: (2-1) inducing demyelination in Schwann cells; (2-2) treating the demyelinated Schwann cells with a candidate material; and (2-3) measuring the level of a Schwann cell proliferation index, a myelination index, or both in the cells treated with the candidate material.
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Citation Information

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