Targeted polymeric nanoparticles loaded with dual therapeutic agents and methods thereof
WO2026006790A3PCT designated stage Publication Date: 2026-02-05MAYO FOUNDATION FOR MEDICAL EDUCATION & RESEARCH
Patent Information
- Application Number
- PCT/US2025/035776
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-06-27
- Filing Date
- 2025-06-27
- Publication Date
- 2026-02-05
AI Technical Summary
Technical Problem
Current chemotherapeutic agents for pancreatic ductal adenocarcinoma (PDAC) face challenges such as poor stability, bioavailability, systemic toxicity, severe side effects, and drug resistance, with combination therapies like Gem and nab-PTX increasing efficacy but also toxicity.
Method used
Development of polymeric nanoparticles loaded with dual therapeutic agents, conjugated with tumor-targeting ligands, to enhance selective delivery and reduce systemic interaction, improving bioavailability and reducing side effects.
Benefits of technology
The nanoparticles achieve targeted delivery, enhanced drug accumulation, increased cellular uptake, and reduced systemic toxicity, leading to improved therapeutic outcomes in PDAC models.
✦ Generated by Eureka AI based on patent content.
Abstract
Provided herein are nanoparticles comprising a triblock copolymer and a targeting moiety for targeted delivery of one or more therapeutic agents, and formulations thereof. Also provided herein are layered drug delivery vehicles. Further provided herein are methods, or uses thereof, for treating cancers, preferably pancreatic and brain cancers, by administration of the nanoparticles disclosed herein.
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Citation Information
Patent Citations
Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids
WO2019204799A1