Processing technology of double-cavity cassette bottle

Abstract

The invention relates to the technical field of medicinal packaging container manufacturing, and discloses a processing technology of a double-cavity cartridge bottle, which comprises the following steps: glass tube loading: selecting a glass tube as a raw material, loading the glass tube into a clamping mechanism of forming equipment, fixing the glass tube through a positioning assembly, enabling the axis of the glass tube to coincide with a processing datum line of the equipment, and forming the glass tube; according to the processing technology of the double-cavity cartridge bottle, double-cavity integrated forming is adopted, the strength and the sealing performance of a separation structure of the main body cavity and the bypass cavity are effectively improved, the sealing hidden danger of split splicing is avoided, the leakage and fracture risks are greatly reduced, the technology is matched with the two forming means that a guide pipe is inserted into blow molding and matched with a mold, and medicinal glass raw materials are compatible; the double-cavity cartridge bottle meets the requirements of medical storage for stability and adaptability, meets the storage requirements of various drugs, reduces drug adsorption and chemical reactions, broadens clinical application scenes, and remarkably improves the practical value of the double-cavity cartridge bottle.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of manufacturing of pharmaceutical packaging containers, in particular to a processing technology of a double-cavity carton bottle. BACKGROUND

[0002] In the clinical drug system, the double-cavity carton bottle has become an important packaging choice for biological preparations and other drugs because it can realize the isolated storage and on-site mixing of two drugs and does not need to be transferred by a syringe twice. However, the existing processing technology of the double-cavity carton bottle still has many core problems that do not match the actual production and use requirements, which need to be solved through targeted process optimization. The bypass structure area of the double-cavity carton bottle is a weak link of the overall structure, and the area is prone to strength defects after being processed by the existing process. The double-cavity carton bottle often needs to be used in combination with the freeze-drying process of biological preparations, and the overall strength of the glass material is prone to decrease after heat and cold alternation, which causes the bypass structure to crack and break. At the same time, the existing process has poor control of the forming precision of the bypass structure, which leads to poor size consistency of the bypass channel, affects the flow efficiency of the drug liquid between the two chambers, and further affects the mixing effect of the biological preparations. SUMMARY

[0003] The present application provides a processing technology of a double-cavity carton bottle, which effectively improves the strength and sealing performance of the separation structure of the main cavity and the bypass cavity by integrated forming of the double cavity, greatly reduces the risk of leakage and breakage, adapts to two forming methods of catheter insertion blow molding and mold cooperation, and is compatible with pharmaceutical-grade glass raw materials, which can meet the requirements of stability and adaptability for pharmaceutical storage and expand the clinical use scenarios.

[0004] In order to achieve the above purpose, the present application adopts the following technical scheme: A processing technology of a double-cavity carton bottle, comprising the following steps: S1. Glass tube loading: selecting a glass tube as a raw material, loading the glass tube into a clamping mechanism of a forming equipment, fixing the glass tube by a positioning assembly to make the axis of the glass tube coincide with the equipment processing reference line; S2. Mouth forming: locally heating a preset mouth area at one end of the glass tube to a plastic state of glass, sleeving a mouth forming mold matched with the preset mouth structure on the heated area, and making the softened glass fit the mold cavity by mold extrusion, and opening the mold after cooling and solidification to obtain a glass blank body with a mouth structure; S3. Bottom end forming: locally heating the end of the glass blank body away from the mouth to a plastic state of glass, and shaping by flame blowing to form the required bottom end structure, and obtaining a tubular initial blank after cooling and solidification; S4. By-pass forming: heating the pre-set by-pass cavity region of the tubular initial blank to a plastic state of the glass, forming the tubular initial blank into a double-cavity structure with the main cavity and the by-pass cavity isolated from each other by means of an adaptive forming method, and obtaining a double-cavity glass blank after cooling.

[0005] Preferably, the adaptive forming method in step S4 is a pipe insertion blow forming, which specifically comprises: inserting a hollow pipe into the pre-set by-pass cavity region heated to a plastic state, blowing clean compressed air through the pipe, and cooperating with an external forming mold with a by-pass cavity protruding contour to limit the position, so that the softened glass expands to adhere to the mold cavity to form the main cavity and the by-pass cavity, maintaining the air pressure until the glass is cooled and solidified, then extracting the pipe and opening the mold.

[0006] Preferably, the adaptive forming method in step S4 is a mold cooperating forming, which specifically comprises: fixing the tubular initial blank in an outer mold cavity with a main cavity outer wall and a by-pass cavity protruding structure, and inserting an inner mold core shaft into the tubular initial blank; after heating to maintain the plastic state of the glass, closing the outer mold cavity and applying pressure to make the glass adhere to the outer wall of the inner mold core shaft and the inner wall of the outer mold cavity to shape, forming the main cavity, the by-pass cavity and the isolation structure between the two cavities, and extracting the inner mold core shaft and opening the mold after cooling and solidification.

[0007] Preferably, the temperature of the local heating in steps S2 and S3 is controlled to be above the softening point of the glass and below the melting point.

[0008] Preferably, in the pipe insertion blow forming of step S4, the clean compressed air is subjected to drying and filtering treatment; and the transition between the by-pass cavity protruding contour and the main cavity contour of the external forming mold is a circular arc structure.

[0009] Preferably, in the mold cooperating forming of step S4, the inner mold core shaft is provided with an isolation rib corresponding to the double-cavity separation position during shaping, and the surface of the inner mold core shaft is coated with a release agent.

[0010] Preferably, the positioning assembly in step S1 is a mechanical positioning assembly, and the axis deviation of the glass tube after positioning is controlled within a preset precision range.

[0011] Preferably, the cavity of the bottle mouth forming mold in step S2 comprises a sealing adaptation surface and a filling interface contour, and the cavity of the bottom end forming mold in step S3 comprises a plug embedding groove and a sealing step.

[0012] Preferably, the glass tube in step S1 is a pharmaceutical grade borosilicate glass tube or a pharmaceutical grade neutral glass tube.

[0013] Preferably, in the double-cavity glass blank obtained in step S4, the transition between the by-pass cavity and the main cavity is smooth.

[0014] Compared with the prior art, the present application has the following beneficial effects: The double-cavity cassette bottle processing process of the present application adopts double-cavity integrated forming, effectively improves the separation structure strength and sealing performance of the main cavity and the bypass cavity, avoids the sealing hidden danger of split splicing, greatly reduces the leakage and rupture risk, the process adapts to the two forming means of catheter insertion blow molding and mold cooperation, and is compatible with pharmaceutical grade glass raw materials, meets the requirements of stability and adaptability for pharmaceutical storage, adapts to the storage requirements of various drugs, reduces drug adsorption and chemical reaction, widens the clinical use scene, and significantly improves the practical value of the double-cavity cassette bottle. BRIEF DESCRIPTION OF DRAWINGS

[0015] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiments will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0016] Figure 1 The mold forming process flowchart of the present application is shown in the figure. Figure 2 The blow molding process flowchart of the present application is shown in the figure. DETAILED DESCRIPTION

[0017] The present application will be described in further detail below with reference to the accompanying drawings.

[0018] The following description is used to disclose the present application so that those skilled in the art can implement the present application. The preferred embodiments in the following description are only used as examples, and other obvious modifications can be thought by those skilled in the art. The basic principles of the present application defined in the following description can be used in other embodiments, modifications, improvements, equivalents and other technical solutions without departing from the spirit and scope of the present application.

[0019] Those skilled in the art should understand that in the disclosure of the present application, the orientation or position indicated by the terms "longitudinal", "transverse", "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or position relationship shown in the drawings, which is only for the convenience of the simplified description of the present application, and does not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore the above terms cannot be understood as a limitation of the present application.

[0020] It can be understood that the term "one" should be understood as "at least one" or "one or more", that is, in one embodiment, the number of one element can be one, and in another embodiment, the number of the element can be multiple, and the term "one" cannot be understood as a limitation of the number.

[0021] Embodiment One: Please refer to Figure 1 A processing technology of a double-cavity cassette bottle, the specific process steps are as follows: 1. Glass tube loading Select glass tube as raw material, select pharmaceutical grade borosilicate glass tube as raw material, load glass tube into clamping mechanism of forming equipment, fix glass tube through mechanical positioning assembly, adjust to make glass tube axis coincide with equipment processing reference line, control axis deviation within preset precision range.

[0022] 2. Bottle mouth forming Local heating is performed on the preset bottle mouth area of one end of the glass tube to make the glass in the area reach a plastic state, i.e. a softened but not molten state; insert the internal shaping part matching the preset bottle mouth structure into the glass tube, and the external shaping part matches the corresponding area outside the glass tube, start the equipment to drive the glass tube to rotate; during the rotation of the glass tube, through the cooperative extrusion action of the internal shaping part and the external shaping part, the softened glass completely matches the profile of the shaping part, after the glass cools and solidifies, remove the internal and external shaping parts and open the mold, get a glass blank with complete bottle mouth structure, which needs to match the subsequent pharmaceutical piston and filling equipment, directly determines the subsequent sealing reliability and filling convenience, is the key basic step of the process.

[0023] 3. Bottom end forming Adjust the fixed position of the glass blank in the clamping mechanism, take the end away from the bottle mouth as the bottom end processing end matched with the plug block; local heating is performed on the bottom end processing end to make the glass reach a plastic state, the softened end is shaped by flame blowing, the heat and airflow of the flame make the softened glass form the required bottom end structure, after the flame blowing is shaped, the glass cools and solidifies to get a tubular initial blank with one end as a bottle mouth and the other end as a plug block bottom end.

[0024] 4. Bypass forming Local heating is performed on the preset bypass cavity area of the tubular initial blank to make the glass in the area maintain a plastic state; fix the tubular initial blank in the outer mold cavity containing the outer wall profile of the main body cavity and the protruding structure of the bypass cavity, ensure that the tubular initial blank is in contact with the inner wall of the outer mold cavity; insert the inner mold core shaft into the tubular initial blank, the profile of the inner mold core shaft needs to match the internal structure of the main body cavity and the bypass cavity; continue to heat the outer mold cavity to make the glass maintain a plastic state, then close the outer mold cavity and apply a preset pressure, so that the glass is shaped tightly to the outer wall of the inner mold core shaft and the inner wall of the outer mold cavity under the combined action of heat and pressure, forming the main body cavity, the bypass cavity and the isolation structure between the two cavities; maintain the pressure until the glass cools and solidifies, then pull out the inner mold core shaft and open the outer mold cavity to get a double-cavity glass body.

[0025] In steps 2 and 3, the local heating temperature must be controlled above the glass softening point and below the melting point. This temperature range ensures that the glass only softens to a malleable state, avoiding glass melting and deformation due to excessively high temperature or difficulty in shaping due to excessively low temperature, thus ensuring the strength and integrity of the glass structure after molding. The positioning component in step 1 is preferably a mechanical positioning component. After positioning, the axial deviation of the glass tube is controlled within a preset accuracy range to ensure the dimensional accuracy of subsequent forming. In step 2, the inner and outer plastic parts cavities used for bottle neck molding must include a sealing adaptation surface and a filling interface outline. In step 3, the cavity of the bottom molding mold must include a stopper insertion groove and a sealing step to ensure the fitting and sealing effect between the bottle neck and the pharmaceutical piston, and between the bottom and the stopper, respectively. In the double-cavity glass substrate obtained in step 4, the surface at the transition between the bypass cavity and the main cavity must be kept smooth. This design can ensure smooth movement of the subsequent pharmaceutical piston, avoid piston damage caused by friction between the piston and the transition, or biological agent residue due to surface roughness, and ensure medication safety.

[0026] Example 2: In step 4 of the above embodiment, bypass molding is performed using a conduit insertion blow molding method: the pre-set bypass cavity area of ​​the tubular preform is locally heated to maintain the plastic state of the glass in that area; a hollow conduit of suitable specifications is inserted from the bottle mouth end of the tubular preform, and the position of the conduit is adjusted so that the front end of the conduit is aligned with the heated pre-set bypass cavity area; clean compressed air is introduced into the tubular preform through the hollow conduit, and at the same time, an external molding mold containing the protruding outline of the bypass cavity is fitted onto the outside of the pre-set bypass cavity area of ​​the tubular preform to achieve positioning; the pressure of the clean compressed air needs to be controlled within a preset range so that the softened glass expands outward under the action of air pressure and fits tightly against the cavity outline of the external molding mold, thereby forming the main cavity and the bypass cavity; the current air pressure is maintained until the glass cools and solidifies, then the compressed air is stopped, the hollow conduit is pulled out from the bottle mouth end and the external molding mold is opened to obtain a double-cavity glass substrate; When the conduit is inserted into the blow molding process, the clean compressed air used must be dried and filtered. This process removes impurities, moisture, and microorganisms from the air, preventing contamination of the inner glass wall and ensuring the safety of the double-cavity glass substrate in contact with the biological agent. The transition between the protruding contour of the bypass cavity and the contour of the main cavity of the external molding mold must be designed as an arc structure. This design can prevent cracks caused by stress concentration during glass expansion and shaping, improve the strength of the bypass structure area, and reduce the risk of breakage during subsequent use. If a mold is used for molding (as in Example 1), a release agent must be applied to the surface of the inner mold core. This release agent must be of a type that meets pharmaceutical standards to prevent the glass substrate from sticking to the inner mold core after molding, ensuring a smooth demolding process, and preventing release agent residue from affecting the safety of the biological agent.

[0027] Those skilled in the art should understand that the embodiments of the present invention described above and shown in the accompanying drawings are merely examples and do not limit the present invention. The objectives of the present invention have been fully and effectively achieved. The functions and structural principles of the present invention have been shown and explained in the embodiments, and any modifications or variations of the embodiments of the present invention may be made without departing from the stated principles.

Claims

1. A process for the manufacture of a dual chamber carton bottle, characterized in that, The method comprises the following steps: S1. Glass tube loading: select a glass tube as a raw material, load the glass tube into a clamping mechanism of a forming device, fix the glass tube through a positioning assembly, and make the axis of the glass tube coincide with a processing reference line of the device; S2. Bottle mouth forming: locally heat a preset bottle mouth area at one end of the glass tube to a plastic state of glass, adopt a forming mode in which an internal shaping part cooperates with an external shaping part, cooperate the internal and external shaping parts during self-rotation of the glass tube, and obtain a glass blank with a bottle mouth structure after cooling and solidification; S3. Bottom end forming: locally heat one end of the glass blank away from the bottle mouth to a plastic state of glass, shape by flame blowing, form a required bottom end structure, and obtain a tubular initial blank after cooling and solidification; S4. Bypass forming: heat a preset bypass cavity area of the tubular initial blank to a plastic state of glass, make the tubular initial blank form a double-cavity structure of a main cavity and a bypass cavity through an adaptive forming means, and obtain a double-cavity glass blank after cooling.

2. The process for manufacturing a dual cavity clamshell bottle according to claim 1, wherein, The adaptive forming means in step S4 is a pipe insertion blow forming, specifically including: introducing an air flow into the preset bypass cavity area heated to a plastic state, cooperating with a special external forming die for limiting shaping, making the softened glass adhere to the die cavity to form the main cavity and the bypass cavity, maintaining the forming conditions until the glass cools and solidifies, and then completing the mold opening and the removal of the forming part.

3. The process for manufacturing a dual cavity clamshell bottle of claim 1, wherein, The adaptive forming means in step S4 is a mold cooperation forming, specifically including: placing the tubular initial blank in an external mold cavity with a double-cavity contour and loading an internal shaping part, closing the mold and pressing after heating and maintaining the plastic state of the glass, making the glass adhere to the internal and external mold cavity contours to form a double-cavity structure, removing the internal shaping part and opening the mold after cooling and solidification.

4. The process for manufacturing a dual cavity clamshell bottle of claim 1, wherein, The temperature of the local heating in steps S2 and S3 is controlled to be above the softening point of glass and below the melting point.

5. The process for manufacturing a dual cavity clamshell bottle of claim 2, wherein, In the pipe insertion blow forming of step S4, the clean compressed air is subjected to drying and filtering treatment; the transition between the bypass cavity convex contour and the main cavity contour of the external forming die is a circular arc structure.

6. The process for manufacturing a dual cavity clamshell bottle of claim 1, wherein, The positioning assembly in step S1 is a mechanical positioning assembly, and the axis deviation of the glass tube after positioning is controlled within a preset precision range.

7. The process for manufacturing a dual cavity clamshell bottle of claim 1, wherein, The glass tube in step S1 is a pharmaceutical grade borosilicate glass tube or a pharmaceutical grade neutral glass tube.

8. The process for manufacturing a dual cavity clamshell bottle of claim 1, wherein, In the double-cavity glass blank obtained in step S4, the connection transition surface between the bypass cavity and the main cavity is smooth.

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