Compounds useful for the treatment of disorders and methods related thereto

Abstract

The present disclosure relates to naphthylethylamine, quinolylethylamine, isoquinolynethylamine, and cinnolynethylamine derivative compounds of general Formula (I), to processes for their preparation, to compositions including naphthylethylamine, quinolylethylamine, isoquinolynethylamine, and cinnolynethylamine derivative compounds of general Formula (I), and to their use for treating diseases, disorders, or conditions. The diseases, disorders, or conditions include, for example, mental illnesses and neurological disorders.

Description

COMPOUNDS USEFUL FOR THE TREATMENT OF DISORDERS AND METHODS RELATED THERETOCROSS-REFERENCE TO RELATED APPLICATION(S) AND CLAIM OF PRIORITY

[0001] This application claims the benefit of priority of U.S. Provisional Application No. 63 / 666,425 filed in the U.S. Patent & Trademark Office on July 1 , 2024, the complete disclosure of which is incorporated herein by reference.FIELD

[0002] The application relates to naphthylethylamine, quinolylethylamine, isoquinolynethylamine, and cinnolynethylamine derivative compounds of general Formula (I), and methods of using such compounds, including methods for the treatment of different diseases, disorders, and conditions, including, for example, mental illnesses and neurological diseases, disorders, and conditions in the fields of psychiatry, neurobiology, and pharmacotherapy, among others.BACKGROUND

[0003] Mental health disorders, or mental illnesses, refer to a wide range of disorders that include, but are not limited to, depressive disorders, anxiety and panic disorders, schizophrenia, eating disorders, substance misuse disorders, post-traumatic stress disorder, attention deficit / hyperactivity disorder, and obsessive-compulsive disorder. Many mental health disorders, as well as neurological disorders, are impacted by alterations, dysfunction, degeneration, and / or damage to the brain.

[0004] There is a need in the art for development of compounds for additional effective treatments for the above and other diseases, disorders, and conditions discussed herein.SUMMARY

[0005] This Summary is provided to introduce a selection of representative concepts in a simplified form, which representative concepts are further described below in the Detailed Description. This Summary is not necessarily intended to identify key features or essential features of the claimed subject matter, nor is it or the objects and benefits described herein intended to be used to limit the scope of the claimed subject matter.

[0006] The present application includes one or more compounds of Formula (I) or a stereoisomer thereof:or a pharmaceutically acceptable salt, solvate, and / or prodrug thereof, wherein:Xais selected from CR5and N;Xbis selected from CR6and N;R1is selected from halogen, OH, optionally substituted OCi-C6alkyl, optionally substituted OC(O)Ci-C6alkyl, optionally substituted OC(O)Ci-C6alkyleneC(O)OR33, optionally substituted OC(O)Ci-C24alkenyl, SH, optionally substituted SCi-C6alkyl, optionally substituted S(O)(Ci- Cealkyl), optionally substituted S(O)2(Ci-Cealkyl), optionally substituted SC(O)Ci- C6alkyleneC(O)OR33, OP(O)(OH)2, optionally substituted Ca-Ciocycloalkyl, optionally substituted 3- to 10-membered heterocycloalkyl, optionally substituted 5- to 10-membered heteroaryl, optionally substituted 0-(C3-Ciocycloalkyl), optionally substituted 0(3- to 10- membered)heterocycloalkyl, andor a stereoisomer thereof;R2is selected from H, D, halogen, and optionally substituted Ci-C6alkyl;R3is selected from H, D, halogen, and optionally substituted Ci-C6alkyl;R4is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;R5is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;R6is selected from H, D, halogen, and optionally substituted Ci -Cealkyl ;R7is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;Q is selected from:over a bond means that the bond is attached to a remaining portion of the compound;R8is selected from optionally substituted Ci-Cealkyl and optionally substituted C3-C5cycloalkyl;R9is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted C3- Cscycloalkyl;R10is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, and R11is selected from H, D, halogen, and optionally substituted Ci-Cealkyl; ortogether form a carbonyl group having a structureR12is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, and R13is selected from H, D, halogen, and optionally substituted Ci-Cealkyl; ortogether form a carbonyl group having a structureR14is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, and R15is selected from H, D, halogen, and optionally substituted Ci-Cealkyl; ortogether form a carbonyl group having a structureR16is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted C1- CealkyleneOCi-Cealkyl;R17is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC1- C6alkyl, SH, and optionally substituted SCi-Cealkyl;R18is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, and R19is selected from H, D, halogen, and optionally substituted Ci-Cealkyl; ortogether form a carbonyl group having a structureR20is selected from H, D, halogen, and optionally substituted Ci-CBalkyl, and R21is selected from H, D, halogen, and optionally substituted Ci-CBalkyl; ortogether form a carbonyl group having a structureR22is selected from halogen, optionally substituted Ci-CBalkyl, OH, optionally substituted OCi- CBalkyl, SH, and optionally substituted SCi-CBalkyl;R23is selected from H, D, halogen, and optionally substituted Ci-CBalkyl, and R24is selected from H, D, halogen, and optionally substituted Ci-CBalkyl;.23R24together form a carbonyl group having a structureR25is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted Ci- CealkyleneOCi-Cealkyl;R26is selected from halogen, optionally substituted Ci-CBalkyl, OH, optionally substituted OCi- Cealkyl, SH, and optionally substituted SCi-CBalkyl;R27is selected from halogen, optionally substituted Ci-CBalkyl, OH, optionally substituted OC1- CBalkyl, SH, and optionally substituted SCi-CBalkyl;R28is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted Ci- CealkyleneOCi-Cealkyl;R29is selected from halogen, optionally substituted Ci-CBalkyl, OH, optionally substituted OCr CBalkyl, SH, and optionally substituted SCi-CBalkyl;R30is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted Cr CealkyleneOCi-Cealkyl;R31is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OCi- Cealkyl, SH, and optionally substituted SCi-Cealkyl;R32is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted Ci- CealkyleneOCi-Cealkyl;R33is selected from H, D, and optionally substituted C-i-Cealkyl; k is selected from 0 and 1 ; m is selected from 0 and 1 ; n is selected from 0 and 1 ; p is selected from 0 and 1 ; q is selected from 0 and 1 ; r is selected from 0 and 1 ; one or more available hydrogen atoms are optionally and independently replaced with one or more respective halogen atoms and / or one or more available atoms are optionally and independently replaced with one or more respective alternative isotopes thereof, none of R8, R9, R16, R25, R28, R30, R32, and R33consist of only a halogen atom; and the compound of Formula (I) is not selected from the following:

[0007] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, and R2to R7and R1° to R13are each H, then R8and / or R9are independently selected from Cs-Cealkyl, Cs-Cehaloalkyl, and Cs-Cedeuterohaloalkyl. In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , and R1is OH or optionally substituted OCi-C6alkyl, then R8and / or R9are independently selected from C5-C6haloalkyl and C5-C6deuterohaloalkyl.

[0008] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, and R2to R7and R10to R13are each H, then R8and / or R9are independently selected from Cs-Cghaloalkyl and Cs-Cgdeuterohaloalkyl. In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , and R1is OH or optionally substituted OCi-Cealkyl, then R8and / or R9are independently selected from Cs-Cehaloalkyl and Cs-Csdeuterohaloalkyl.

[0009] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, and R2to R7and R10to R13are each H, then R8and / or R9are independently selected from Cs-Csdeuteroalkyl and Cs-Csdeuterohaloalkyl. In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , and R1is OH or optionally substituted OCi-Cgalkyl, then R8and / or R9are independently selected from Cs-Cedeuteroalkyl and Cs-Csdeuterohaloalkyl.

[0010] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, and R2to R7and R10to R13are each H, then R8and / or R9are independently selected from Ci-Csdeuteroalkyl, Ci-Cgdeuterohaloalkyl, and Ci- Csdeuterohaloalkyl. In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , and R1is OH or optionally substituted OCi-Cealkyl, thenR8and / or R9are independently selected from Ci-Csdeuteroalkyl, Ci-Cedeuterohaloalkyl, and Ci- Csdeuterohaloalkyl.

[0011] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, and R2to R7and R10to R13are each H, then R8and / or R9are independently selected from Ci-Cehaloalkyl and C-rCedeuterohaloalkyl. In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , and R1is OH or optionally substituted OCi-Cealkyl, then R8and / or R9are independently selected from CrCehaloalkyl and Ci-Cgdeuterohaloalkyl.

[0012] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, R2to R7and R10to R13are each H, then R8and / or R9are independently selected from Ci-Cedeuteroalkyl and Ci-Cedeuterohaloalkyl. In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, Q is Q1 , and R1is OH or optionally substituted OCi-C6alkyl, then R8and / or R9are independently selected from C-i-Cedeuteroalkyl and Ci-Csdeuterohaloalkyl.

[0013] In some embodiments, the compound includes one or more of the following attributes:(a) when Xaand Xbare CR5and CR6, respectively, then R5and R6are not both H; or(b) Xais N; or(c) Xbis N; or(d) R3is not H; or(e) R7is not H; or(f) R1is neither OH nor optionally substituted OCi-Cealkyl; or(g) R1is OC(O)Ci-C6alkyleneC(O)OR33; or(h) Q is not Q1 ; or(i) any combination of two or more of (a), (b), (c), (d), (e), (f), (g), and (h).

[0014] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, then none of R2, R3, R5, R6, and R7is a halogen.

[0015] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, then at least two of R2, R3, R5, R6, and R7are independently halogens.

[0016] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, and Q is Q1 having a structure selected from:then none of R2, R3, R5, R6, and R7is a halogen, or at least two of R2, R3, R5, RB, and R7are independently halogen.

[0017] In some embodiments, the compound has a structure of Formula (I), provided that when Xais CR5, Xbis CR6, and Q is Q3 having a structure:then none of R2, R3, R5, R6, and R7is a halogen, or at least two of R2, R3, R5, R6, and R7are independently halogen.

[0018] In some embodiments, the compound is not selected from a deuterated analog of any of the following and stereoisomers thereof:2-(8-methoxynaphthalen-1 -yl)-N,N-dimethylethan-1 -amine;8-(2-(dimethylamino)ethyl)naphthalen-1-ol;N,N-diethyl-2-(8-methoxynaphthalen-1 -yl)ethan-1 -amine;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-propylpropan-1 -amine;N-isopropyl-N-(2-(8-methoxynaphthalen-1-yl)ethyl)propan-2-amine;N-ethyl-2-(8-methoxynaphthalen-1 -yl)-N-methylethan-1 -amine;8-(2-(ethyl(methyl)amino)ethyl)naphthalen-1-ol;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-methylpropan-1 -amine;N-(2-(8-methoxynaphthalen-1-yl)ethyl)-N-methylpropan-2 -amine;8-(2-(isopropyl(methyl)amino)ethyl)naphthalen-1-ol;2-(8-methoxynaphthalen-1-yl)-N-methylethan-1 -amine;2-(8-fluoronaphthalen-1 -yl)-N-methylethan-1 -amine;2-(8-chloronaphthalen-1 -yl)-N-methylethan-1 -amine; and2-(8-bromonaphthalen-1 -yl)-N-methylethan-1 -amine.

[0019] In some embodiments, the compound is not selected from a deuterated or halogenated analog of any of the following and stereoisomers thereof:2-(8-methoxynaphthalen-1 -yl)-N,N-dimethylethan-1 -amine;8-(2-(dimethylamino)ethyl)naphthalen-1-ol;N,N-diethyl-2-(8-methoxynaphthalen-1 -yl)ethan-1 -amine;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-propylpropan-1 -amine;N-isopropyl-N-(2-(8-methoxynaphthalen-1-yl)ethyl)propan-2-amine;N-ethyl-2-(8-methoxynaphthalen-1 -yl)-N-methylethan-1 -amine;8-(2-(ethyl(methyl)amino)ethyl)naphthalen-1-ol;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-methylpropan-1 -amine;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-methylpropan-2 -amine;8-(2-(isopropyl(methyl)amino)ethyl)naphthalen-1-ol;2-(8-methoxynaphthalen-1 -yl)-N-methylethan-1 -amine;2-(8-fluoronaphthalen-1 -yl)-N-methylethan-1 -amine;2-(8-chloronaphthalen-1 -yl)-N-methylethan-1 -amine; and2-(8-bromonaphthalen-1 -yl)-N-methylethan-1 -amine.

[0020] In a further embodiment, the compounds of the disclosure are used as medicaments. Accordingly, the disclosure also includes a compound of the disclosure for use in the making or manufacture of a medicament.

[0021] In other embodiments, the compounds of the disclosure are used as ingredients in compositions and pharmaceutical compositions, including medicaments.

[0022] The present disclosure also includes a method of treating a disease, disorder, and / or condition comprising administering a therapeutically effective amount of one or more compounds of the disclosure to a subject in need thereof. In some embodiments, the compounds of the disclosure are used to make medicaments for treatment of a disease, disorder, and / or condition. In some embodiments, the present disclosure relates to use of one or more compounds of this disclosure in the making or manufacture of a medicament for treating a disease, disorder, and / or condition.

[0023] The present disclosure also includes a method of treating depressive disorder, bipolar disorder, eating disorder, impulse control disorder, personality disorder, substance abuse disorder, behavioral addiction disorder, alcohol use disorder, post-traumatic stress disorder, anxiety disorder, stress disorder, neurodevelopmental disorder, pain disorder, headache disorder, inflammatory disorder, injury-related disorder, neurodegenerative disorder, functional disorder, psychotic disorder, hyperkinetic movement disorder, age-related macular degeneration, atherosclerosis, dissociative disorders, genetic brain disorders, hyperprolactinemia, hypersomnia, obesity, phobias, apathy disorders, and / or burnout. In some embodiments, the compounds of the disclosure are used to make medicaments for treatment of a depressive disorder, bipolar disorder, eating disorder, impulse control disorder, personality disorder, substance abuse disorder, alcohol use disorder, behavioral addiction disorder, post-traumatic stress disorder, anxiety disorder, stress disorder, neurodevelopmental disorder, pain disorder, headache disorder, inflammatory disorder, injury-related disorder, neurodegenerative disorder, functional disorder, psychotic disorder, hyperkinetic movement disorder, age-related macular degeneration, atherosclerosis, dissociative disorders, genetic brain disorders, hyperprolactinemia, hypersomnia, obesity, phobias, apathy disorders, and / or burnout. In some embodiments, the present disclosure relates to use of one or more compounds of this disclosure in the making or manufacture of a medicament for treating depressive disorder, bipolar disorder, eating disorder, impulse control disorder, personality disorder, substance abuse disorder, behavioral addiction disorder, alcohol use disorder, post-traumatic stress disorder, anxiety disorder, stress disorder, neurodevelopmental disorder, pain disorder, headache disorder, inflammatory disorder, injury-related disorder, neurodegenerative disorder, functional disorder, psychotic disorder, hyperkinetic movement disorder, age-related macular degeneration,atherosclerosis, dissociative disorders, genetic brain disorders, hyperprolactinemia, hypersomnia, obesity, phobias, apathy disorders, and / or burnout.

[0024] The disclosure additionally provides a process for the preparation of compounds of the disclosure. The disclosure further provides use of compounds of the disclosure in the making or manufacture of medicines. General and specific processes are discussed in more detail below and set forth in the examples below.

[0025] This disclosure further provides intermediates for the compounds disclosed herein, methods of making the intermediates, and methods for making the compounds from the intermediates.

[0026] Other features of the present disclosure will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating embodiments of the disclosure, are given by way of illustration only and the scope of the claims should not be limited by these embodiments but should be given the broadest interpretation consistent with the description as a whole.DETAILED DESCRIPTIONI. Definitions

[0027] Unless otherwise indicated, the definitions and embodiments described in this section and other sections are intended to be applicable to all embodiments and aspects of the present disclosure herein described for which they are suitable as would be understood by a person skilled in the art.

[0028] The present description refers to a number of chemical terms and abbreviations used by those skilled in the art. Nevertheless, definitions of selected terms are provided for clarity and consistency.

[0029] As used in the present disclosure, the singular forms “a,” “an,” and “the" include plural references unless the content clearly dictates otherwise. For example, an embodiment including “a compound” should be understood to present certain aspects with one compound, or two or more additional compounds. It will be understood by those with skill in the art that if a specific number of an introduced claim element is intended, such intent will be explicitly recited in the claim, and in the absence of such recitation no such limitation is present. For a non-limiting example, as an aid to understanding, the appended claims contain usage of the introductory phrases “at least one” and “one or more” to introduce claim elements. However, the use of suchphrases should not be construed to imply that the introduction of a claim element by the indefinite articles “a” or “an” limits any particular claim containing such introduced claim element to embodiments containing only one such element, even when the same claim includes the introductory phrase “one or more” or “at least one” and indefinite articles, such as “a” or “an”; the same holds true for the use in the claims of definite articles.

[0030] The terms “about,” “substantially,” and “approximately,” as used herein, mean a reasonable amount of deviation of the modified term such that the end result is not significantly changed. These terms of degree should be construed as including a deviation of at least ±5% of the modified term if this deviation would not negate the meaning of the word it modifies or unless the context suggests otherwise to a person skilled in the art.

[0031] In embodiments comprising an “additional” or “second” component, such as an additional or second compound, the second component, as used herein, is not the same component as the other components or first component. A “third” component is not the same component as the other, first and second components and further enumerated or “additional” components are similarly different components. It should be understood, for example, that although a first group and a second group refer to two groups, the first and second groups may be the same species, for example, both Ci-C6alkyl, or methyl. “First,” “second,” “third,” etc. in this context is not meant to imply an order or sequence, other than the order in which the terms appear in the claims, unless the claims clearly indicate otherwise.

[0032] The term “administered,” as used herein, means administration of a therapeutically effective amount of one or more compounds or compositions of the disclosure to a cell, tissue, organ, or subject.

[0033] The term “alkenyl,” as used herein, whether it is used alone or as part of another group, means substituted or unsubstituted, straight or branched chain, unsaturated hydrocarbon groups containing at least one double bond. The term C2-Cealkenyl (or C2-salkenyl) means an alkenyl group having 2, 3, 4, 5, or 6 carbon atoms. An alkenyl may contain other unsaturated alkyl groups, such as at least one triple bond. Alkenyl groups may be substituted by alkyl or alkynyl groups.

[0034] The term “alkyl,” as used herein, whether it is used alone or as part of another group, means substituted or unsubstituted, straight or branched chain, saturated hydrocarbon groups, unless the context clearly indicates otherwise, e.g., an “unsubstituted alkyl” is not substituted . The term “Ci-Cealkyl” (or “C-i-ealkyl”) means an alkyl group having 1 , 2, 3, 4, 5, or 6 carbon atoms and includes, for example, any of the hexyl alkyl and pentyl alkyl isomers as well as n-, iso-, sec- andtert-butyl, n- and iso-propyl, ethyl, and methyl. As another example, “Ci-C4alkyl” refers to n-, iso- , sec- and tert-butyl, n- and isopropyl, ethyl, and methyl. Unless otherwise stated, an “alkyl” group includes all isomers. As another example, “C 1 alkyl” refers to a methyl group; “C2alkyl” refers to an ethyl group; “C3alkyl” refers to a propyl group (e.g., n-propyl or iso-propyl)); “C4alkyl” refers to a butyl group (e.g., n-butyl, sec-butyl, isobutyl, or tert-butyl); “Csalkyl” refers to a pentyl group and any of its isomers; and “Cealkyl” refers to a hexyl group and any of its isomers.

[0035] The term “alkynyl,” as used herein, whether it is used alone or as part of another group, means substituted or unsubstituted, straight or branched chain, unsaturated hydrocarbon groups containing at least one triple bond. The term C^Cealkynyl (or C2-6alkynyl) means an alkynyl group having 2, 3, 4, 5, or 6 carbon atoms. Alkynyl groups may be substituted by alkyl or alkenyl groups.

[0036] The term “alternate isotope thereof’ or “alternative isotope thereof,” as used herein, refers to an isotope of an element that is other than the isotope that is most abundant in nature.

[0037] The term “and / or,” as used herein, means that one or more of the listed items are present, or used, individually or in combination. In effect, this term means that “at least one of” or “one or more” of the listed items is used or present. The term “and / or” with respect to pharmaceutically acceptable salts and / or solvates thereof means that the compounds of the disclosure exist as individual salts or solvates, as well as a combination of, for example, a salt of a solvate of a compound of the disclosure. As used herein, the term “and / or” means either or both (or any combination or all of the terms or expressions referred to), e.g., “A, B, and / or C” encompasses A alone; B alone; C alone; A and B; A and C; B and C; and A, B, and C.

[0038] The term “any member, combination, or subset thereof,” as used herein, when used to refer to a preceding list of possible members, means that any individual listed member, possible combination of listed members, or subset of listed members may be included. For example, if Z is selected from A, B, C, and D, including any member, combination, or subset thereof, then Z may be A, B, C, and D; A, B, and C; A, B, and D; A, C, and D; B, C, and D; A and B; A and C; A and D; B and C; B and D; C and D; A alone; B alone; C alone; or D alone. As another example, if A is Ci-C4alkyl, then subsets of A (in the context of a subset of A, B, C, and D) includes Cialkyl alone, C2alkyl alone, C3alkyl alone, C4alkyl alone, Ci-C2alkyl, Ci-C3alkyl, Ci-C4alkyl, C2-C3alkyl, C2-C4alkyl, and C3-C4alkyl.

[0039] The term “aryl,” as used herein, whether it is used alone or as part of another group, refers to a substituted or unsubstituted aromatic carbocyclic ring or multi-ring structures (e.g., bi-cyclic). For example, for an aryl group that contains the prefix Ce-Cio, the corresponding carbocyclic group(s) contains 6, 7, 8, 9, or 10 carbon ring atoms.

[0040] The term “available,” as in “available hydrogen atoms” or “available atoms” refers to atoms that would be known to a person skilled in the art to be capable of replacement by a substituent.

[0041] The term “benzofused,” as used herein, refers to a polycyclic group in which a benzene ring is fused with another ring.

[0042] A first ring being “bridged” with a second ring means the first ring and the second ring share two non-adjacent atoms there between.

[0043] The term “composition(s) of the disclosure” or “composition(s) of the present disclosure” and the like, as used herein, refers to a composition, such a pharmaceutical composition, comprising one or more compounds of the disclosure.

[0044] The term “compound(s) of the disclosure” or “compound(s) of the present disclosure” and the like, as used herein, refers to a compound Formula (I) and includes, in some embodiments, pharmaceutically acceptable salts, solvates, and / or prodrugs thereof, unless the context clearly dictates otherwise.

[0045] As used in this disclosure and claim(s), the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “include” and “includes”) or “containing” (and any form of containing, such as “contain” and “contains”), are inclusive or open- ended and do not exclude additional, unrecited elements or process steps.

[0046] The term “consisting” and its derivatives, as used herein, are intended to be closed terms that specify the presence of the stated features, elements, components, groups, integers and / or steps and also exclude the presence of other unstated features, elements, components, groups, integers, and / or steps.

[0047] The term “consisting essentially of,” as used herein, is intended to specify the presence of the stated features, elements, components, groups, integers, and / or steps as well as those that do not materially affect the basic and novel characteristic(s) of those features, elements, components, groups, integers, and / or steps.

[0048] All “cyclic” groups, including aryl, heteroaryl, heterocycloalkyl, and cycloalkyl groups, contain one ring or more than one ring (i.e. , are optionally polycyclic), unless otherwise indicated.When a cyclic group contains more than one ring, the rings may be fused, bridged, spirofused, or linked by a bond.

[0049] The term “cycloalkyl,” as used herein, whether it is used alone or as part of another group, means a substituted or unsubstituted, saturated or unsaturated, non-aromatic, carbocyclic ring or multi-ring structures (e.g., bi-cyclic), unless otherwise specified. For example, the term C3- Czcycloalkyl (or C -zcycloalkyl) means a cycloalkyl group having 3, 4, 5, 6, or 7 ring carbon atoms. A cycloalkyl is optionally fused to another ring, including fused to an aryl ring (e.g., benzofused) or heteroaryl ring.

[0050] The term “deuteroalkenyl,” as used herein, refers to an alkenyl group as defined above in which one or more of the available hydrogen atoms have been independently replaced with one or more respective deuterium atoms. Thus, for example, “Cz-Cedeuteroalkenyl” (or “C2- edeuteroalkenyl”) refers to a two-carbon to six-carbon linear or branched alkenyl group as defined above with one or more deuterium substituents, and optionally one or more non-deuterium substitutes.

[0051] The term “deuteroalkyl,” as used herein, refers to an alkyl group as defined above in which one or more of the available hydrogen atoms have been independently replaced with one or more respective deuterium atoms. Thus, for example, “Ci-Cgdeuteroalkyl” (or "Ci- sdeuteroalkyl”) refers to a one-carbon to six-carbon linear or branched alkyl group as defined above with one or more deuterium substituents, and optionally one or more non-deuterium substitutes.

[0052] The term “deuterohaloalkenyl,” as used herein, refers to an alkenyl group as defined above in which one or more of the available hydrogen atoms have been independently replaced with one or more respective deuterium atoms and one or more of the available hydrogen atoms have been independently replaced with one or more respective halogen atoms. Thus, for example, “C2-C6deuterohaloalkenyl” (or “C2-6deuterohaloalkenyl”) refers to a two-carbon to six- carbon linear or branched alkenyl group as defined above with one or more deuterium substituents and one or more halogen substituents, and optionally one or more non-deuterohalo substitutes.

[0053] The term “deuterohaloalkyl,” as used herein, refers to an alkyl group as defined above in which one or more of the available hydrogen atoms have been independently replaced with one or more respective deuterium atoms and one or more of the available hydrogen atoms have been independently replaced with one or more respective halogen atoms. Thus, for example, “Ci.Csdeuterohaloalkyl” (or “Ci-edeuterohaloalkyl”) refers to a one-carbon to six-carbon linear or branched alkyl group as defined above with one or more deuterium substituents and one or more halogen substituents, and optionally one or more non-deuterohalo substitutes.

[0054] The term “disease, disorder, or condition,” as used herein, refers to a disease, disorder, or condition treated or treatable using one or more compounds of the disclosure herein described.

[0055] The term “effective amount” or “therapeutically effective amount” as used herein means an amount of one or more compounds of the disclosure that is effective, at dosages and for periods of time necessary to achieve the desired result. For example, in the context of treating a disease, disorder, or condition, an effective amount is an amount that, for example, treats, palliates, and / or prevents said disease, disorder, or condition compared to the non-treatment, non-palliation, or non-prevention without administration of the one or more compounds.

[0056] The suffix “ene” at the end of a group (for example "alkylene”) means that the group is bivalent, that is that it is bonded to two variables each on a different end of or location on the group. An alkylene may be substituted or unsubstituted, straight or branched chain. The number of carbon atoms that are possible in the referenced alkylene group are indicated by the prefix “Cn- Cm” and “Co” where n, m, and o are integers. Thus, for example, the term “Ci-Cealkylene” (or “Ci- ealkylene”) means an alkylene group having 1 , 2, 3, 4, 5, or 6 carbon atoms and includes, for example, any of the hexylene and pentylene isomers as well as n-, iso-, sec- and tert-butylene, n- and iso-propylene, ethylene, and methylene. Unless otherwise stated, an “alkylene” group includes all isomers. As another example, “Cialkylene” refers to a methylene group; “C2alkylene” refers to an ethylene group; “C3alkylene” refers to a propylene group (e.g., n-propylene or isopropylene)); “C4alkylene” refers to a butylene group (e.g., n-butylene, sec-butylene, isobutylene, or tert-butylene)); “Csalkylene" refers to a pentylene group and any of its isomers; and “Cealkylene” refers to a hexylene group and any of its isomers. As another example, “propylene” includes n- propylene and iso-propylene; “butylene” includes n-butylene, sec-butylene, isobutylene, and tertbutylene)); etc.

[0057] The word “exemplary” is used herein to mean “serving as an example, instance, or illustration.” Any implementation described herein as “exemplary” is not necessarily to be construed as preferred or advantageous over other implementations. Reference throughout this specification to “a select embodiment,” “one embodiment,” “an exemplary embodiment,” “exemplary embodiments,” “an embodiment,” “some embodiments,” or “embodiments” means that a particular feature, structure, or characteristic described in connection with the embodiment(s) is included in at least one embodiment. Thus, appearances of the phrases "in aselect embodiment,” “in one embodiment,” “in an exemplary embodiment,” “in exemplary embodiments,” “in some embodiments,” “in an embodiment,” “some embodiments,” or “in embodiments” in various places throughout this specification are not necessarily referring to the same embodiment(s) or only a single embodiment. The embodiments may be, for example, combined with one another in various combinations and modified to include features of one another.

[0058] A first ring being “fused” with a second ring means the first ring and the second ring share two adjacent atoms there between.

[0059] The term “halo” (or “halogen”) whether it is used alone or as part of another group, refers to a halogen atom and includes fluoro, chloro, bromo, and iodo.

[0060] As used herein, the term “haloalkenyl” refers to an alkenyl group as defined above in which one or more of the available hydrogen atoms have been independently replaced with one or more respective halogen atoms. Thus, for example, “C2-C6haloalkenyl” (or “C2-6haloalkenyl”) refers to a two-carbon to six-carbon linear or branched alkenyl group as defined above with one or more halogen substituents, and optionally one or more non-halogen substitutes.

[0061] The term “haloalkyl,” as used herein, refers to an alkyl group as defined above in which one or more of the available hydrogen atoms have been independently replaced with one or more respective halogen atoms. Thus, for example, “Ci-Cehaloalkyl” (or“Ci-6haloalkyl”) refers to a one- carbon to six-carbon linear or branched alkyl group as defined above with one or more halogen substituents, and optionally one or more non-halogen substitutes.

[0062] The term “heteroaryl,” as used herein, whether it is used alone or as part of another group, refers to substituted or unsubstituted aromatic ring or multi-ring structures (e.g., bi-cyclic), in which one or more of the atoms of the aromatic ring are a heteromoiety independently selected from O, S, and N, including oxidized or substituted versions thereof (e.g., S(O) and S(O)2), and the remaining atoms are C, unless otherwise specified. When a heteroaryl group contains the prefix of, for example, C5-C10, this prefix indicates that the corresponding carbocyclic group(s) contains 5, 6, 7, 8, 9, or 10 carbon atoms in the ring, in which one or more, suitably 1 to 5, of the ring atoms is replaced with a heteroatom as defined above. Heteroaryl groups may also be preceded by, for example, “5- to 10-membered” which refers to the total number of ring atoms (in this example, 5, 6, 7, 8, 9, or 10 atoms) in the aromatic ring or multi-ring structures, including the heteroatom(s). Heteroaryl groups may be benzofused.

[0063] The term “heterocycloalkyl,” as used herein, whether it is used alone or as part of another group, refers to substituted or unsubstituted, saturated or non -saturated, non-aromatic ring or non-aromatic multi-ring structures (e.g., bi-cyclic), in which one or more of the ring atoms of the non-aromatic ring or non-aromatic multi-ring structure are independently selected from O, S, and N, including oxidized or substituted versions thereof (e.g., S(O) and S(O)2), and the remaining atoms are C, unless otherwise specified. Heterocycloalkyl groups are either saturated or unsaturated (i.e., contain one or more double bonds) and / or optionally comprise one or more C=O groups (i.e., one or more carbon atoms in the ring is oxidized to C=O). When a heterocycloalkyl group contains a prefix, such as C3-C10, this prefix indicates that the corresponding carbocyclic group contains 3, 4, 5, 6, 7, 8, 9, or 10 carbon atoms in the ring, in which one or more, suitably 1 to 5, of the ring atoms are replaced with a heteromoiety independently selected from O, S, and N including oxidized or substituted versions thereof, and the remaining atoms are C. Similarly, heterocycloalkyl groups may also be preceded by a prefix, such as “3- to 10-membered,” which refers to the total number of atoms in the ring(s) (in this example, 3, 4, 5, 6, 7, 8, 9, or 10 atoms). Heterocycloalkyl groups are optionally fused to another ring, including fused to an aryl ring (e.g., benzofused) or heteroaryl ring.

[0064] As used herein, the term “one or more” items includes a single item selected from the list as well as two or more items (e.g., combinations and mixtures) selected from the list.

[0065] The term “one or more available atoms are optionally and independently replaced with one or more respective alternative isotopes thereof,” and the like, as used herein, means that at least one available atom, optionally a plurality, and optionally each and every available atom, is optionally and independently replaced with an isotope of that atom having the same atomic number, but an atomic mass or mass number different from the atomic mass or mass number predominantly found in nature. When a compound comprises an atom that has been replaced with an alternative isotope thereof, the compound comprises that alternative isotope in greater amounts than would otherwise be present in the compound if said replacement had not taken place. In some embodiments, the alternative isotope is deuterium.

[0066] The term “one or more available hydrogen atoms are optionally and independently replaced with one or more respective halogen atoms,” and the like as used herein, means that at least one available hydrogen atom, optionally a plurality, and optionally each and every available hydrogen atom, is optionally and independently replaced with a halogen atom, and that the replacements are independent of one another.

[0067] The term “one or more available hydrogen atoms are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms,” and the like, as used herein, means that at least one available hydrogen atom, optionally a plurality, and optionally each and every available hydrogen atom, is optionally and independently replaced with a specified halogen atom (e.g., a fluorine atom, a chlorine atom, and / or a bromine atom), and the replacements are independent of one another, e.g., the compound may include only F; only Cl; only Br; both F and Cl; both F and Br; both Cl and Br; or a combination of F, Cl, and Br replacements.

[0068] The term “optionally substituted,” as used herein, means that the subject group is unsubstituted or substituted and the terms “optionally substituted” and “unsubstituted or substituted” are used interchangeably herein. As used herein, when referring to more than one item or “each” item, “optionally substituted” and “unsubstituted or substituted” means that the items are independently unsubstituted or substituted with respect to one another, e.g., for item A and item B that are optionally substituted, both may be substituted, both may be unsubstituted, or one may be substituted and the other unsubstituted. Additionally, as used herein, the term “optionally substituted” when referring to more than one item means that if more than one of the items is substituted, the substitutions may be independent from one another, e.g., for item A and item B that are both substituted, item A may have a first substitution and item B may have a second substitution that is the same or different from the first substitution of item A.

[0069] “Palliating” a disease, disorder, or condition means that the extent and / or undesirable clinical manifestations of a disease, disorder, or condition are lessened and / or time course of the progression is slowed or lengthened, as compared to not treating the disorder.

[0070] The term “pharmaceutically acceptable” means compatible with the treatment of subjects.

[0071] The term “pharmaceutically acceptable carrier” means a non-toxic solvent, dispersant, excipient, adjuvant, or other material which is mixed or otherwise combined with the active ingredient in order to permit the formation of a pharmaceutical composition, i.e., a dosage form capable of administration to a subject.

[0072] The term “pharmaceutically acceptable salt” means either an acid addition salt or a base addition salt which is suitable for, or compatible with, the treatment of subjects. An acid addition salt suitable for, or compatible with, the treatment of subjects is any non-toxic organic or inorganic acid addition salt of any basic compound. A base addition salt suitable for, or compatible with, thetreatment of subjects is any non-toxic organic or inorganic base addition salt of any acidic compound.

[0073] The term “prevention” or “prophylaxis,” or synonym thereto, as used herein, refers to a reduction in the risk or probability of a patient becoming afflicted with a disease, disorder, or condition or manifesting a symptom associated with a disease, disorder, or condition.

[0074] The term “prodrug,” as used herein, means a compound, or salt of a compound, that, after administration, is converted into an active drug.

[0075] The term “protecting group” or “PG” and the like, as used herein, refers to a chemical moiety which protects or masks a reactive portion of a molecule to prevent side reactions in those reactive portions of the molecule, while manipulating or reacting a different portion of the molecule. After the manipulation or reaction is complete, the protecting group is removed under conditions that do not degrade or decompose the remaining portions of the molecule. The selection of a suitable protecting group can be made by a person skilled in the art. Many conventional protecting groups are known in the art, for example as described in “Protective Groups in Organic Chemistry,” McOmie, J.F.W. Ed., Plenum Press, 1973, in Greene, T.W. and Wuts, P.G.M., “Protective Groups in Organic Synthesis,” John Wiley & Sons, 3rdEdition, 1999 and in Kocienski, P. Protecting Groups, 3rd Edition, 2003, Georg Thieme Verlag (The Americas).

[0076] The term “solvate,” as used herein, means a compound, or a salt or prodrug of a compound, wherein molecules of a suitable solvent are incorporated in the crystal lattice. A suitable solvent is physiologically tolerable at the dosage administered.

[0077] A first ring being “spirofused” with a second ring means the first ring and the second ring share one atom there between.

[0078] The term “subject,” as used herein, includes all members of the animal kingdom including mammals, and suitably refers to humans. Thus, the methods of the present disclosure are applicable to both human therapy and veterinary applications.

[0079] The term “substituted,” as used herein, means, unless otherwise indicated, that the referenced group is substituted with one or more independently selected substituents. When a group is substituted with more than one substituent selected from a list of substituents, each of the substituents is independently selected from the listed group of substituents unless otherwise indicated.

[0080] The term “suitable,” as used herein, means that the selection of the particular compound or conditions would depend on the specific synthetic manipulation to be performed, the identity of the molecule(s) to be transformed and / or the specific use for the compound, but the selection would be well within the skill of a person trained in the art. All process / method steps described herein are to be conducted under conditions sufficient to provide the product shown. A person skilled in the art would understand that all reaction conditions, including, for example, reaction solvent, reaction time, reaction temperature, reaction pressure, reactant ratio, and whether or not the reaction should be performed under an anhydrous or inert atmosphere, can be varied to control the yield of the desired product and it is within their skill to do so.

[0081] The term “therapeutic agent,” as used herein, refers to any drug or active agent that has a pharmacological effect when administered to a subject.

[0082] The term “treating” or “treatment,” as used herein, and as is well understood in the art, means an approach for obtaining beneficial or desired results, including clinical results. Beneficial or desired clinical results include, but are not limited to, alleviation or amelioration of one or more symptoms or conditions, diminishment of extent of disease, stabilized (i.e. , not worsening) state of disease, preventing spread of disease, delay, or slowing of disease progression, amelioration or palliation of the disease state, diminishment of the reoccurrence of disease and remission (whether partial or total), whether detectable or undetectable. “Treating” and “treatment” can also mean prolonging survival as compared to expected survival if not receiving treatment. “Treating” and “treatment,” as used herein, also include prophylactic treatment. Treatment methods comprise administering to a subject a therapeutically effective amount of one or more of the compounds of the disclosure and optionally consist of a single administration, or alternatively comprise a series of administrations.

[0083] The term “treating a disease, disorder, or condition,” as used herein, means that the disease, disorder, or condition to be treated is affected by, modulated by, and / or has some biological basis.II. Compounds

[0084] The present disclosure includes a compound of Formula (I) or a stereoisomer thereof:or a pharmaceutically acceptable salt, solvate, and / or prodrug thereof, wherein Q, Xa, Xb, R1, R2,R3R4R5R® R7R8R9R10R11R12R13R14R15R16R17R18R19R20R21R22R23R24R25R26, R27, R28, R29, R30, R31, R32, R33, k, m, n, p, q, and rare as defined (and provisos and exclusions provided for) in the Summary above and exemplified below.

[0085] In some embodiments, one or more available hydrogen atoms are optionally and independently replaced with one or more respective halogen atoms independently selected from fluorine, chlorine, and bromine and / or one or more available atoms are optionally and independently replaced with one or more respective isotope atoms.

[0086] In some embodiments, one or more available hydrogen atoms are optionally and independently replaced with one or more respective halogen atoms independently selected from fluorine and chlorine and / or one or more available atoms are optionally and independently replaced with one or more respective isotope atoms.

[0087] In some embodiments, one or more available hydrogen atoms are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms are optionally and independently replaced with one or more respective isotope atoms.

[0088] In some embodiments, one or more available hydrogen atoms are optionally and independently replaced with one or more respective deuterium atoms.

[0089] In some embodiments, Xais selected from CR5and N. In some embodiments, Xais CR5. In some embodiments, Xais N.

[0090] In some embodiments, Xbis selected from CR6and N. In some embodiments, Xbis CR6. In some embodiments, Xbis N.

[0091] In some embodiments, R1is selected from halogen, OH, optionally substituted OCi- C6alkyl, optionally substituted OC(O)Ci-C6alkyl, optionally substituted OC(O)Ci-C6alkyleneC(O)OR33, optionally substituted OC(O)Ci-C24alkenyl, SH, optionally substituted SCi- Cealkyl, optionally substituted S(O)(Ci-C6alkyl), optionally substituted S(O)2(Ci-Csalkyl), optionally substituted SC(O)Ci-C6alkyleneC(O)OR33, OP(O)(OH)2, optionally substituted C3- Ciocycloalkyl, optionally substituted 3- to 10-membered heterocycloalkyl, optionally substituted 5- to 10-membered heteroaryl, optionally substituted 0-(C3-Ciocycloalkyl), optionally substituted O- (3- to 10-membered)heterocycloalkyl, andor a stereoisomer thereof, including any member, combination, or subset thereof.

[0092] In some embodiments, R1is unsubstituted. In some embodiments, R1is substituted. In some embodiments, R1is substituted with one or more substituents independently selected from OH and Ci-C6alkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof. In some embodiments, the OCi-Cealkyl, OC(O)Ci-C6alkyl, OC(O)Ci-C6alkyleneC(O)OR33, OC(O)Ci-C24alkenyl, SCi-C6alkyl, S(O)(Ci-C6alkyl), S(O)2(Ci-C6alkyl), SC(O)Ci- C6alkyleneC(O)OR33, Cs-Ciocycloalkyl, 3- to 10-membered heterocycloalkyl, 5- to 10-membered heteroaryl, 0-(C3-Ciocycloalkyl), and / or 0(3- to 10-membered)heterocycloalkyl of R1is optionally substituted with at least one substituent independently selected from halo, Ci-C4alkyl, O(Ci- C4alkyl), Ci-C4haloalkyl, O(Ci-C4haloalkyl), CN, OH, NH2, NH(Ci-C4alkyl), N(Ci-C4alkyl)(Ci- C4alkyl), S(Ci-C4alkyl), S(O)Ci-C4alkyl, S(O)2(Ci-C4alkyl), CO2H, CO2(Ci-C4alkyl), C(O)NH2|C(O)NH(Ci-C4alkyl), C(O)N(Ci-C4alkyl)(Ci-C4alkyl), Cs-C / cycloalkyl, and a 3- to 6-membered heterocyclic ring including 1 to 3 ring heteromoieties independently selected from O, S, S(O), S(O)2, N, NH, and N(Ci-C4alkyl).

[0093] In some embodiments, R1is halogen, i.e., is selected from F, Cl, Br, and I, including any member, combination, or subset thereof. In some embodiments, R1is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R1is a halogen selected from fluorine and bromine. In some embodiments, R1is a halogen selected from fluorine and chlorine. In some embodiments, R1is a halogen selected from chlorine and bromine. In some embodiments, R1isfluorine. In some embodiments, R1is chlorine. In some embodiments, R1is bromine. In some embodiments, R1is iodine. In some embodiments, R1is not halogen.

[0094] In some embodiments, R1includes an alkyl moiety (e.g., of optionally substituted OCi- Cealkyl, optionally substituted OC(O)Ci-Cealkyl, optionally substituted SCi-Cealkyl, optionally substituted S(O)(Ci-Cealkyl), and optionally substituted S(O)2(Ci-C6alkyl)). In some embodiments, each alkyl moiety of R1is independently Ci-Cealkyl. In some embodiments, each alkyl moiety of R1is independently Ci-Csalkyl. In some embodiments, each alkyl moiety of R1is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R1is independently Ci- Caalkyl. In some embodiments, each alkyl moiety of R1is independently Ci-Czalkyl. In some embodiments, each alkyl moiety of R1is independently C2-Cealkyl. In some embodiments, each alkyl moiety of R1is independently C2-Csalkyl. In some embodiments, each alkyl moiety of R1is independently C2-C4alkyl. In some embodiments, each alkyl moiety of R1is independently C2- CsalkyL In some embodiments, each alkyl moiety of R1is independently Ca-Cealkyl. In some embodiments, each alkyl moiety of R1is independently Ca-Csalkyl. In some embodiments, each alkyl moiety of R1is independently C3-C4alkyl. In some embodiments, each alkyl moiety of R1is independently C4-Cealkyl. In some embodiments, each alkyl moiety of R1is independently C4- C5alkyl. In some embodiments, each alkyl moiety of R1is independently C5-C6alkyl.

[0095] In some embodiments, each alkyl moiety of R1is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R1are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, each alkyl moiety of R1is independently unsubstituted Ci-C6alkyl. In some embodiments, each alkyl moiety of R1is independently substituted Ci-C6alkyl.

[0096] In some embodiments, each alkylene moiety of R1(e.g., of optionally substituted OC(O)Ci-C6alkyleneC(O)OR33, optionally substituted SC(O)Ci-C6alkyleneC(O)OR33) is independently Ci-C6alkylene. In some embodiments, each alkylene moiety of R1is independently C-i-Csalkylene. In some embodiments, each alkylene moiety of R1is independently Ci-C4alkylene. In some embodiments, each alkylene moiety of R1is independently Ci-Caalkylene. In some embodiments, each alkylene moiety of R1is independently Ci-C2alkylene. In some embodiments, each alkylene moiety of R1is independently C2-CBalkylene. In some embodiments, each alkylene moiety of R1is independently C2-C5alkylene. In some embodiments, each alkylene moiety of R1is independently C2-C4alkylene. In some embodiments, each alkylene moiety of R1isindependently C2-C3alkylene. In some embodiments, each alkylene moiety of R1is independently Ca-Csalkylene. In some embodiments, each alkylene moiety of R1is independently Cs-Csalkylene. In some embodiments, each alkylene moiety of R1is independently C3-C4alkylene. In some embodiments, each alkylene moiety of R1is independently C^-Cgalkylene. In some embodiments, each alkylene moiety of R1is independently C4-C5alkylene. In some embodiments, each alkylene moiety of R1is independently Cs-Cealkylene.

[0097] In some embodiments, each alkylene moiety of R1is independently selected from alkylene, deuteroalkylene, haloalkylene, and deuterohaloalkylene, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkylene moiety of R1are replaced by a halogen atom and none of the available atoms of the alkylene moiety of R1are replaced by an alternative isotope thereof. In some embodiments, each alkylene moiety of R1is independently unsubstituted Ci-C8alkylene. In some embodiments, each alkylene moiety of R1is independently substituted Ci-C8alkylene.

[0098] In some embodiments, the alkenyl moiety of R1(e.g., optionally substituted OC(O)C2- C24alkenyl) is C2-C24alkenyl. In some embodiments, the alkenyl moiety of R1is C3-C24alkenyl. In some embodiments, the alkenyl moiety of R1is C4-C24alkenyl. In some embodiments, the alkenyl moiety of R1is C8-C24alkenyl. In some embodiments, the alkenyl moiety of R1is Ci2-C24alkenyl. In some embodiments, the alkenyl moiety of R1is Ci6-C24alkenyl. In some embodiments, the alkenyl moiety of R1is C20-C24alkenyl. In some embodiments, the alkenyl moiety of R1is C2- C2oalkenyl. In some embodiments, the alkenyl moiety of R1is C4-C2oalkenyl. In some embodiments, the alkenyl moiety of R1is CB-C2oalkenyl. In some embodiments, the alkenyl moiety of R1is Ci2-C2oalkenyl. In some embodiments, the alkenyl moiety of R1is Ci6-C2oalkenyl. In some embodiments, the alkenyl moiety of R1is C2-Ci6alkenyl. In some embodiments, the alkenyl moiety of R1is C4-Ci6alkenyl. In some embodiments, the alkenyl moiety of R1is C8-Ci6alkenyl. In some embodiments, the alkenyl moiety of R1is Ci2-CiBalkenyl. In some embodiments, the alkenyl moiety of R1is C2-Ci2alkenyl. In some embodiments, the alkenyl moiety of R1is C4-Ci2alkenyl. In some embodiments, the alkenyl moiety of R1is C8-Ci2alkenyl. In some embodiments, the alkenyl moiety of R1is C2-C8alkenyl. In some embodiments, the alkenyl moiety of R1is C4-C8alkenyl. In some embodiments, the alkenyl moiety of R1is C2-C4alkenyl.

[0099] In some embodiments, the alkenyl moiety of R1is selected from optionally substituted alkenyl, optionally substituted deuteroalkenyl, optionally substituted haloalkenyl, and optionally substituted deuterohaloalkenyl, including any member, combination, or subset thereof. In some embodiments, none of the available atoms of the alkenyl moiety of R1are replaced by analternative isotope thereof. In some embodiments, none of the available hydrogen atoms of the alkenyl moiety of R1are replaced by a halogen atom. In some embodiments, none of the available hydrogen atoms of the alkenyl moiety of R1are replaced by a halogen atom and none of the available atoms of the alkenyl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, the alkenyl moiety of R1is unsubstituted alkenyl. In some embodiments, the alkenyl moiety of R1is substituted alkenyl.

[0100] In some embodiments, R1includes a cycloalkyl moiety (e.g., of optionally substituted C3- Ciocycloalkyl and optionally substituted O-(C3-C cycloalkyl)). In some embodiments, each cycloalkyl moiety of R1is independently Cs-C cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently Cs-Cscycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently Cs-C / cycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently Cs-CecycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently Cs-CscycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently C3-C4cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently C4-Ci0cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently C4-Cacycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently C4-C7cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently C4-C6cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently C4-C5cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently Cs-C-iocycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently Cs-CscycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently Cs-C cycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently C5-C6cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently Ce-C-iocycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently Ce-CscycloalkyL In some embodiments, each cycloalkyl moiety of R1is independently Ce-C cycloalkyL In some embodiments, each cycloalkyl moiety of R1is

[0101] In some embodiments, each cycloalkyl moiety of R1is independently selected from optionally substituted cycloalkyl, optionally substituted deuterocycloalkyl, optionally substituted halocycloalkyl, and optionally substituted deuterohalocycloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available atoms of the cycloalkyl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of the cycloalkyl moiety of R1are replaced by a halogenatom. In some embodiments, none of the available hydrogen atoms of the cycloalkyl moiety of R1are replaced by a halogen atom and none of the available atoms of the cycloalkyl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, each cycloalkyl moiety of R1is independently unsubstituted cycloalkyl. In some embodiments, each cycloalkyl moiety of R1is independently substituted cycloalkyl.

[0102] In some embodiments, R1includes a heterocycloalkyl moiety (e.g., of 3- to 10- membered heterocycloalkyl and optionally substituted O-(3- to 10-membered)heterocycloalkyl). In some embodiments, each heterocycloalkyl moiety of R1is independently 3- to 10-membered heterocycloalkyl. In some embodiments, each heterocycloalkyl moiety of R1is independently 3- to 8-membered heterocycloalkyl. In some embodiments, each heterocycloalkyl moiety of R1is independently independently 3- to 6-membered heterocycloalkyl. In some embodiments, each heterocycloalkyl moiety of R1is independently 5- to 10-membered heterocycloalkyl. In some embodiments, each heterocycloalkyl moiety of R1is independently 5- to 8-membered heterocycloalkyl. In some embodiments, each heterocycloalkyl moiety of R1is independently 5- to 6-membered heterocycloalkyl.

[0103] In some embodiments, each heterocycloalkyl moiety of R1is independently selected from optionally substituted heterocycloalkyl, optionally substituted deuteroheterocycloalkyl, optionally substituted haloheterocycloalkyl, and optionally substituted deuterohaloheterocycloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available atoms of the heterocycloalkyl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of the heterocycloalkyl moiety of R1are replaced by a halogen atom. In some embodiments, none of the available hydrogen atoms of the heterocycloalkyl moiety of R1are replaced by a halogen atom and none of the available atoms of the heterocycloalkyl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, each heterocycloalkyl moiety of R1is independently unsubstituted heterocycloalkyl. In some embodiments, each heterocycloalkyl moiety of R1is independently substituted heterocycloalkyl.

[0104] In some embodiments, R1includes a heteroaryl moiety (e.g., of optionally substituted 5- to 10-membered heteroaryl). In some embodiments, the heteroaryl moiety of R1is selected from 5- to 10-membered heteroaryl. In some embodiments, the heteroaryl moiety of R1is selected from 5- to 8-membered heteroaryl. In some embodiments, the heteroaryl moiety of R1is selected from 5- to 6-membered heteroaryl.

[0105] In some embodiments, the heteroaryl moiety of R1is selected from optionally substituted heteroaryl, optionally substituted deuteroheteroaryl, optionally substituted haloheteroaryl, and optionally substituted deuterohaloheteroaryl, including any member, combination, or subset thereof. In some embodiments, none of the available atoms of the heteroaryl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of the heteroaryl moiety of R1are replaced by a halogen atom. In some embodiments, none of the available hydrogen atoms of the heteroaryl moiety of R1are replaced by a halogen atom and none of the available atoms of the heteroaryl moiety of R1are replaced by an alternative isotope thereof. In some embodiments, the heteroaryl moiety of R1is unsubstituted heteroaryl. In some embodiments, the heteroaryl moiety of R1is substituted heteroaryl.

[0106] In some embodiments, R1is selected from OH and optionally substituted OCi-CealkyL In some embodiments, OCi-Cealkyl is unsubstituted. In some embodiments, OC-i-Cealkyl is substituted. In some embodiments, R1is selected from OH, OD, and optionally substituted OCi- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R1is selected from OH, OD, OCH3, OCH2D, OCHD2, OCD3, OCH2F, OCHF2, OCF3, OCH2CH3, OCD2CD3, OCF2CF3, OCH(CH3)2, OCH(CD3)2, OCH(CF3)2, OCD(CD3)2, OCF(CF3)2, OC(CH3)3lOC(CD3)3, and OC(CF3)3, including any member, combination, or subset thereof. In some embodiments, R1is selected from OH, OCH3, OCHF2, OCF3, OCD3, OCHZCH3, OCH(CH3)2, OCH(CD3)2, and OC(CH3)3, including any member, combination, or subset thereof. In some embodiments, R1is selected from OCH3and OCHF2. In some embodiments, R1is OCH3. In some embodiments, R1is OCHF2.

[0107] In some embodiments, R1is selected from optionally substituted OC(O)Ci-C6alkyl, optionally substituted OC(O)Ci-C6alkyleneC(O)OR33, and optionally substituted OC(O)Ci- C24alkenyl, including any member, combination, or subset thereof. In some embodiments, OC(O)Ci-C6alkyl, OC(O)Ci-CealkyleneC(O)OR33, and OC(O)Ci-C24alkenyl are independently unsubstituted. In some embodiments, OC(O)Ci-C6alkyl, OC(O)Ci-C6alkyleneC(O)OR33, and OC(O)Ci-C24alkenyl are independently substituted. In some embodiments, R1is OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH3.

[0108] In some embodiments, R1is selected from SH, optionally substituted SCi-Cealkyl, optionally substituted S(O)(Ci-Cealkyl), optionally substituted S(O)2(Ci-C6alkyl), and optionally substituted S(O)Ci-C6alkyleneC(O)OR33, including any member, combination, or subset thereof. In some embodiments, SCi-Cealkyl, S(O)(Ci-C6alkyl), S(O)2(Ci-Cealkyl), and S(O)Ci- CealkyleneC(O)OR33are independently unsubstituted. In some embodiments, SCi-Cealkyl,S(0)(Ci-C6alkyl), S(O)2(Ci-C6alkyl), and S(O)Ci-C6alkyleneC(O)OR33are independently substituted. In some embodiments, R1is selected from SH, SD, and optionally substituted SCi- Cealkyl, including any member, combination, or subset thereof .

[0109] In some embodiments, R33is selected from H, D, and optionally substituted Ci-Cealkyl, and does not consist of solely a halogen atom, i.e., R33is not F, Cl, Br, or I. In some embodiments, R33includes an alkyl moiety (e.g., optionally substituted Ci-Cealkyl). In some embodiments, R33is independently C-i-Cealkyl. In some embodiments, each alkyl moiety of R33is independently C-i- Csalkyl. In some embodiments, each alkyl moiety of R33is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R33is independently Ci-Caalkyl. In some embodiments, each alkyl moiety of R33is independently Ci-C2alkyl. In some embodiments, each alkyl moiety of R33is independently C2-Cealkyl. In some embodiments, each alkyl moiety of R33is independently C2- CsalkyL In some embodiments, each alkyl moiety of R33is independently C2-C4alkyl. In some embodiments, each alkyl moiety of R33is independently C2-C3alkyl. In some embodiments, each alkyl moiety of R33is independently Cs-Cgalkyl. In some embodiments, each alkyl moiety of R33is independently C3-C5alkyl. In some embodiments, each alkyl moiety of R33is independently selected from C3-C4alkyl. In some embodiments, each alkyl moiety of R33is independently C4- C6alkyl. In some embodiments, each alkyl moiety of R33is independently C4-C5alkyl. In some embodiments, each alkyl moiety of R33is independently Cs-Cgalkyl.

[0110] In some embodiments, each alkyl moiety of R33is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R33are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R33are replaced by an alternative isotope thereof. In some embodiments, each alkyl moiety of R33has one or more hydrogen atoms independently replaced by one or more respective halogen atoms and / or one or more atoms independently replaced by one or more respective alternative isotopes thereof. In some embodiments, each R33is independently selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0111] In some embodiments, each alkyl moiety of R33is independently unsubstituted. In some embodiments, the alkyl moiety of R33is independently substituted. In some embodiments, each alkyl moiety of R33is independently substituted with one or more substituents independently selected from OH and Ci-C6alkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0112] In some embodiments, each R33independently includes at least one deuterium atom. In some embodiments, each R33independently includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective halogen atoms (i.e. , F, Cl, Br, and / or I) and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R33are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R33are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R33are replaced with a halogen atom. In some embodiments, none of the available atoms of R33are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R33are replaced with a halogen atom and none of the available atoms of R33are replaced with an alternative isotope thereof.

[0113] In some embodiments,

[0114] In some embodiments, R1is selected from optionally substituted Cs-Ciocycloalkyl, optionally substituted 3- to 10-membered heterocycloalkyl, optionally substituted 5- to 10- membered heteroaryl, optionally substituted 0-(C3-Ciocycloalkyl), and optionally substituted O- (3- to 10-membered)heterocycloalkyl, including any member, combination, or subset thereof.

[0116] In some embodiments, R1is selected from tetrahydrofuranyl (e.g.,

[0117] In some embodiments, R1is selected from OH, optionally substituted OCi-C3alkyl, OC(O)CH3, optionally substituted OC(O)Ci-C3alkyleneC(O)OH, SH, SCH3, OP(O)(OH)2, optionally substituted OC(O)Ci-Ci8alkenyl, optionally substituted C3-C6cycloalkyl, optionally substituted 3- to 6-membered heterocycloalkyl, optionally substituted 5- to 6-membered heteroaryl, optionally substituted O(C3-C6Cycloalkyl), and optionally substituted O-(3- to 6- membered) heterocycloalkyl, including any member, combination, or subset thereof. In some embodiments, the aforementioned members are independently unsubstituted. In some embodiments, the aforementioned members are independently substituted.

[0118] In some embodiments, R1is selected from cyclopropyl (e.g.,tetra hyd rofu ranylOC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, SCH3, SCF3,SC(O)(CH2)3C(O)OH, S(O)CH3, S(O)2CH3, and

[0119] In some embodiments, R1is selected from OH, OCH3, OCHF2, OC(O)CH3, OC(O)(CH2)2C(O)OH, OC(O)(CH2)3C(O)OH, OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH31OP(O)(OH)2, SCH3Jand

[0120] In some embodiments, R1is selected from OH, OCH3, OC(O)(CH2)7CHCH=CH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, and SCH3.

[0121] In some embodiments, R1is selected from OH, OCH3, OCHF2, OP(O)(OH)2|and

[0122] In some embodiments, R1is selected from OCH3and OCHF2.

[0123] In some embodiments, R1includes at least one deuterium atom. In some embodiments, R1includes at least one halogen atom. In some embodiments, one or more available hydrogenatoms of R1are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R1are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R1are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R1are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R1are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R1are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R1are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R1are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R1are replaced with a halogen atom. In some embodiments, none of the available atoms of R1are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R1are replaced with a halogen atom and none of the available atoms of R1are replaced with an alternative isotope thereof.

[0124] In some embodiments, R2is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R2is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R2is halo. In some embodiments, R2is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R2is a halogen selected from fluorine and bromine. In some embodiments,R2is a halogen selected from fluorine and chlorine. In some embodiments, R2is a halogen selected from chlorine and bromine. In some embodiments, R2is fluorine. In some embodiments, R2is chlorine. In some embodiments, R2is bromine. In some embodiments, R2is iodine. In some embodiments, R2is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R2is D.

[0125] In some embodiments, R2includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R2is Ci-Cealkyl. In some embodiments, the alkyl moiety of R2is C-i-Csalkyl. In some embodiments, the alkyl moiety of R2is Ci-C4alkyl. In some embodiments, the alkyl moiety of R2is Ci-Csalkyl. In some embodiments, the alkyl moiety of R2is C-i-Czalkyl. In some embodiments, the alkyl moiety of R2is Cj-Cealkyl. In some embodiments, the alkyl moiety of R2is Cz-Csalkyl. In some embodiments, the alkyl moiety of R2is C2-C4alkyl. In some embodiments, the alkyl moiety of R2is C2-C3alkyl. In some embodiments, the alkyl moiety of R2is Ca-Cealkyl. In some embodiments, the alkyl moiety of R2is Ca-Csalkyl. In some embodiments, the alkyl moiety of R2is C3-C4alkyl. In some embodiments, the alkyl moiety of R2is C4-C6alkyl. In some embodiments, the alkyl moiety of R2is C4-C5alkyl. In some embodiments, the alkyl moiety of R2is Cs-Cgalkyl.

[0126] In some embodiments, the alkyl moiety of R2is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R2are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R2are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R2is unsubstituted Ci- Cealkyl. In some embodiments, the alkyl moiety of R2is substituted Ci-CealkyL In some embodiments, the alkyl moiety of R2is substituted with one or more substituents independently selected from OH and Ci-C6alkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0127] In some embodiments, R2is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R2is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3ICH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3,CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R2is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2ICH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R2is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3|including any member, combination, or subset thereof. In some embodiments, R2is selected from H, F, CH3, CHD2, CD3ICH2F, CHF2Jand CF3, including any member, combination, or subset thereof . In some embodiments, R2is selected from CH3, CH2F, CHF2, CF3, and CD3, including any member, combination, or subset thereof.

[0128] In some embodiments, R2includes at least one deuterium atom. In some embodiments, R2includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R2are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R2are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R2are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R2are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R2are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R2are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R2are optionally andindependently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R2are replaced with a halogen atom. In some embodiments, none of the available atoms of R2are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R2are replaced with a halogen atom and none of the available atoms of R2are replaced with an alternative isotope thereof.

[0129] In some embodiments, R3is selected from H, D, halogen, and optionally substituted C-i- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R3is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R3is halo. In some embodiments, R3is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R3is a halogen selected from fluorine and bromine. In some embodiments, R3is a halogen selected from fluorine and chlorine. In some embodiments, R3is a halogen selected from chlorine and bromine. In some embodiments, R3is fluorine. In some embodiments, R3is chlorine. In some embodiments, R3is bromine. In some embodiments, R3is iodine. In some embodiments, R3is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R3is D.

[0130] In some embodiments, R3includes an alkyl moiety (e.g., optionally substituted C-i- Cgalkyl). In some embodiments, the alkyl moiety of R3is Ci-Cealkyl. In some embodiments, the alkyl moiety of R3is C Csalkyl. In some embodiments, the alkyl moiety of R3is Ci-C4alkyl. In some embodiments, the alkyl moiety of R3is Ci-Csalkyl. In some embodiments, the alkyl moiety of R3is Ci-CaalkyL In some embodiments, the alkyl moiety of R3is Cz-CealkyL In some embodiments, the alkyl moiety of R3is C2-Csalkyl. In some embodiments, the alkyl moiety of R3is C2-C4alkyl. In some embodiments, the alkyl moiety of R3is C2-C3alkyl. In some embodiments, the alkyl moiety of R3is Cs-Cealkyl. In some embodiments, the alkyl moiety of R3is Cs-Csalkyl. In some embodiments, the alkyl moiety of R3is C3-C4alkyl. In some embodiments, the alkyl moiety of R3is C4-C6alkyl. In some embodiments, the alkyl moiety of R3is C4-Csalkyl. In some embodiments, the alkyl moiety of R3is Cs-Cealkyl.

[0131] In some embodiments, the alkyl moiety of R3is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R3are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R3are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R3is unsubstituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R3is substituted Ci-CealkyL In some embodiments, the alkyl moiety of R3is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0132] In some embodiments, R3is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R3is selected from CH3, CD2H, CDH2ICD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2ICH2CH2CD3, CH(CH3)2JCH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2ICH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3JC(CFH2)3, C(CD3)3IC(CHD2)3, C(CDH2)3JCH2CH2CH2CH3JCH2CH2CH2CF3ICH2CH2CH2CD3ICH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2ICH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3JCH2CH(CH3)CD3ICH2C(CH3)3ICH2C(CF3)3ICH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R3is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2JCH(CD3)2ICH(CF3)2ICD(CD3)21CF(CF3)2, C(CH3)31C(CD3)31and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R3is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R3is selected from H, F, CH3, CHD2, CD3, CH2F, CHF2Iand CF3, including any member, combination, or subset thereof. In some embodiments, R3is selected from CH3, CH2F, CHF2, CF3, and CD3, including any member, combination, or subset thereof.

[0133] In some embodiments, R3includes at least one deuterium atom. In some embodiments, R3includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or moreavailable atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R3are replaced with a halogen atom. In some embodiments, none of the available atoms of R3are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R3are replaced with a halogen atom and none of the available atoms of R3are replaced with an alternative isotope thereof.

[0134] In some embodiments, R4is selected from H, D, halogen, and optionally substituted Ci- C6alkyl, including any member, combination, or subset thereof. In some embodiments, R4is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R4is halo. In some embodiments, R4is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R4is a halogen selected from fluorine and bromine. In some embodiments, R4is a halogen selected from fluorine and chlorine. In some embodiments, R4is a halogen selected from chlorine and bromine. In some embodiments, R4is fluorine. In some embodiments, R4is chlorine. In some embodiments, R4is bromine. In some embodiments, R4is iodine. In some embodiments, R4is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R4is D.

[0135] In some embodiments, R4includes an alkyl moiety (e.g., optionally substituted Cr Cealkyl). In some embodiments, the alkyl moiety of R4is Ci-Cealkyl. In some embodiments, the alkyl moiety of R4is C-i-CsalkyL In some embodiments, the alkyl moiety of R4is Ci-C4alkyl. Insome embodiments, the alkyl moiety of R4is Ci-C3alkyl. In some embodiments, the alkyl moiety of R4is C-i-Czalkyl. In some embodiments, the alkyl moiety of R4is C2-C6alkyl. In some embodiments, the alkyl moiety of R4is C2-Csalkyl. In some embodiments, the alkyl moiety of R4is C2-C4alkyl. In some embodiments, the alkyl moiety of R4is C2-C3alkyl. In some embodiments, the alkyl moiety of R4is Ca-Cealkyl. In some embodiments, the alkyl moiety of R4is Cs-Csalkyl. In some embodiments, the alkyl moiety of R4is C3-C4alkyl. In some embodiments, the alkyl moiety of R4is C4-Cealkyl. In some embodiments, the alkyl moiety of R4is C4-C5alkyl. In some embodiments, the alkyl moiety of R4is Cs-Cealkyl.

[0136] In some embodiments, the alkyl moiety of R4is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R4are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R4are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R4is unsubstituted Ci- Cealkyl. In some embodiments, the alkyl moiety of R4is substituted C-i-Cealkyl. In some embodiments, the alkyl moiety of R4is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e g., CH2OH), including any member, combination, or subset thereof.

[0137] In some embodiments, R4is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R4is selected from CH3, CD2H, CDH2ICD3ICF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2ICH2CH2CD3, CH(CH3)2ICH(CF3)2ICH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3IC(CFH2)3IC(CD3)3, C(CHD2)31C(CDH2)3ICH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2ICH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3JCH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3Jand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R4is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2ICH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3IC(CD3)3Iand C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R4is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R4is selected from H, F, CH3, CHD2, CD3ICH2F, CHF2, and CF3, including any member, combination, or subset thereof . In someembodiments, R4is selected from CH3, CH2F, CHF2, CF3, and CD3, including any member, combination, or subset thereof.

[0138] In some embodiments, R4includes at least one deuterium atom. In some embodiments, R4includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R4are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R4are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R4are replaced with a halogen atom. In some embodiments, none of the available atoms of R4are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R4are replaced with a halogen atom and none of the available atoms of R4are replaced with an alternative isotope thereof.

[0139] In some embodiments, R5is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R5is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R5is halo. In some embodiments, R5is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R5is a halogen selected from fluorine and bromine. In some embodiments, R5is a halogen selected from fluorine and chlorine. In some embodiments, R5is a halogen selected from chlorine and bromine. In some embodiments, R5is fluorine. In some embodiments, R5is chlorine. In some embodiments, R5is bromine. In some embodiments, R5is iodine. In some embodiments, R5is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R5is D.

[0140] In some embodiments, R5includes an alkyl moiety (e.g., optionally substituted C Cealkyl). In some embodiments, the alkyl moiety of R5is Ci-Cealkyl. In some embodiments, the alkyl moiety of R5is CrCsalkyL In some embodiments, the alkyl moiety of R5is Ci-C4alkyl. In some embodiments, the alkyl moiety of R5is Ci-C3alkyl. In some embodiments, the alkyl moiety of R5is Ci-C2alkyl. In some embodiments, the alkyl moiety of R5is Cz-Cealkyl. In some embodiments, the alkyl moiety of R5is C2-C5alkyl. In some embodiments, the alkyl moiety of R5is C2-C4alkyl. In some embodiments, the alkyl moiety of R5is C2-C3alkyl. In some embodiments, the alkyl moiety of R5is Cs-Cealkyl. In some embodiments, the alkyl moiety of R5is Cs-CsalkyL In some embodiments, the alkyl moiety of R5is C3-C alkyl. In some embodiments, the alkyl moiety of R5is C4-C6alkyl. In some embodiments, the alkyl moiety of R5is C4-C5alkyl. In some embodiments, the alkyl moiety of R5is Cs-Cealkyl.

[0141] In some embodiments, the alkyl moiety of R5is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R5are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R5are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R5is unsubstituted Cr Cealkyl. In some embodiments, the alkyl moiety of R5is substituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R5is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0142] In some embodiments, R5is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R5is selected fromCH3, CD2H, CDH2, CD3, CF2H, CFH21CF31CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3ICH2CH2D, CH2CD2H, CH2CD3, CD2CD31CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3ICH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R5is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3JCH(CH3)2JCH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R5is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)31including any member, combination, or subset thereof. In some embodiments, R5is selected from H, F, CH3, CHD2, CD3, CH2F, CHF2Jand CF3, including any member, combination, or subset thereof . In some embodiments, R5is selected from CH3, CH2F, CHF2, CF3, and CD3, including any member, combination, or subset thereof.

[0143] In some embodiments, R5includes at least one deuterium atom. In some embodiments, R5includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R5are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R5are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R5are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R5are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R5are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R5are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R5are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R5are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R5are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R5are optionally and independently replaced with one ormore respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R3are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R3are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R3are replaced with a halogen atom. In some embodiments, none of the available atoms of R3are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R3are replaced with a halogen atom and none of the available atoms of R3are replaced with an alternative isotope thereof.

[0144] In some embodiments, R6is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R6is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R6is halo. In some embodiments, R6is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R6is a halogen selected from fluorine and bromine. In some embodiments, R6is a halogen selected from fluorine and chlorine. In some embodiments, R6is a halogen selected from chlorine and bromine. In some embodiments, RBis fluorine. In some embodiments, R6is chlorine. In some embodiments, R6is bromine. In some embodiments, R6is iodine. In some embodiments, R6is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R6is D.

[0145] In some embodiments, R6includes an alkyl moiety (e.g., optionally substituted Ci- C6alkyl). In some embodiments, the alkyl moiety of R6is C C6alkyl. In some embodiments, the alkyl moiety of R6is Ci-CsalkyL In some embodiments, the alkyl moiety of R6is Ci-C4alkyl. In some embodiments, the alkyl moiety of RBis Ci-CsalkyL In some embodiments, the alkyl moiety of R6is Ci-CsalkyL In some embodiments, the alkyl moiety of RBis C2-Cealkyl. In some embodiments, the alkyl moiety of R6is C2-C5alkyl. In some embodiments, the alkyl moiety of R6is C2-C4alkyl. In some embodiments, the alkyl moiety of R6is C2-C3alkyl. In some embodiments, the alkyl moiety of R6is C3-C6alkyl. In some embodiments, the alkyl moiety of RBis C3-C5alkyl. In some embodiments, the alkyl moiety of RBis C3-C4alkyl. In some embodiments, the alkyl moietyof R6is Czi-Cealkyl. In some embodiments, the alkyl moiety of RBis C^CsalkyL In some embodiments, the alkyl moiety of R6is Cs-Cealkyl.

[0146] In some embodiments, the alkyl moiety of R6is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R6are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R6are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R6is unsubstituted C-i- Cealkyl. In some embodiments, the alkyl moiety of R6is substituted C-i-Cealkyl. In some embodiments, the alkyl moiety of R6is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0147] In some embodiments, R6is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R6is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3ICH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3ICH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)21CH(CD3)2ICH(CHD2)2ICH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3IC(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3JCH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)21CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3JCH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3Jand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R6is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2ICF3ICH2CH3, CD2CD3, CF2CF3, CH(CH3)2ICH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3IC(CD3)3Iand C(CF3)3Jincluding any member, combination, or subset thereof. In some embodiments, R6is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R6is selected from H, F, CH31CHD2, CD3ICH2F, CHF2, and CF3, including any member, combination, or subset thereof . In some embodiments, R6is selected from CH3, CH2F, CHF2, CF3, and CD3, including any member, combination, or subset thereof.

[0148] In some embodiments, R5includes at least one deuterium atom. In some embodiments, R6includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R6are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R6are optionally and independentlyreplaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R6are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R6are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R6are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R6are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R6are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R6are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R6are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R6are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R6are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R6are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of RBare optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R6are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of RBare replaced with a halogen atom. In some embodiments, none of the available atoms of RBare replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of RBare replaced with a halogen atom and none of the available atoms of R6are replaced with an alternative isotope thereof.

[0149] In some embodiments, R7is selected from H, D, halogen, and optionally substituted C-i- C6alkyl, including any member, combination, or subset thereof. In some embodiments, R7is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R7is halo. In some embodiments, R7is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R7is a halogen selected from fluorine and bromine. In some embodiments, R7is a halogen selected from fluorine and chlorine. In some embodiments, R7is a halogen selected from chlorine and bromine. In some embodiments, R7is fluorine. In some embodiments,R7is chlorine. In some embodiments, R7is bromine. In some embodiments, R7is iodine. In some embodiments, R7is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R7is D.

[0150] In some embodiments, R7includes an alkyl moiety (e.g., optionally substituted Ci- Csalkyl). In some embodiments, the alkyl moiety of R7is Ci-Cealkyl. In some embodiments, the alkyl moiety of R7is C-i-Csalkyl. In some embodiments, the alkyl moiety of R7is C C4alkyl. In some embodiments, the alkyl moiety of R7is independently selected from C-i-Caalkyl. In some embodiments, the alkyl moiety of R7is Ci-Cjalkyl. In some embodiments, the alkyl moiety of R7is C2-Cealkyl. In some embodiments, the alkyl moiety of R7is C2-C5alkyl. In some embodiments, the alkyl moiety of R7is C2-C4alkyl. In some embodiments, the alkyl moiety of R7is C2-C3alkyl. In some embodiments, the alkyl moiety of R7is Cs-Cgalkyl. In some embodiments, the alkyl moiety of R7is Ca-Csalkyl. In some embodiments, the alkyl moiety of R7is C3-C4alkyl. In some embodiments, the alkyl moiety of R7is C4-Cgalkyl. In some embodiments, the alkyl moiety of R7is C4-C5alkyl. In some embodiments, the alkyl moiety of R7is Cs-Cealkyl.

[0151] In some embodiments, the alkyl moiety of R7is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R7are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R7are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R7is unsubstituted C-i- CealkyL In some embodiments, the alkyl moiety of R7is substituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R7is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0152] In some embodiments, R7is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R7is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF31CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)21CH(CHF2)2, CH(CFH2)21CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3IC(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH31CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. Insome embodiments, R7is selected from CH3, CH2D, CHD2, CDs, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)21CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R7is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R7is selected from H, F, CH3, CHD2, CD3, CH2F, CHF2, and CF3, including any member, combination, or subset thereof. In some embodiments, R7is selected from CH3, CH2F, CHF2, CF3, and CD3, including any member, combination, or subset thereof.

[0153] In some embodiments, R7includes at least one deuterium atom. In some embodiments, R7includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R7are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R7are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R7are replaced with a halogen atom. Insome embodiments, none of the available atoms of R7are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R7are replaced with a halogen atom and none of the available atoms of R7are replaced with an alternative isotope thereof.

[0154] In some embodiments, Q is selected from:Q7, including any member, combination, or subset thereof.

[0155] In some embodiments Q is selected as Q1 to provide a compound having the structure of Formula (I -A-i):wherein Xa, Xb, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R1Z, and R13are as defined (and provisos and exclusions provided for) herein.

[0156] In some embodiments, when Q is selected as Q1 , a compound is provided having the structure of Formula (I) or Formula (l-A-i), wherein none of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, R10, R11, R12, and R13are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, and R7are replaced with respective alternative isotopes thereof.

[0157] In some embodiments, the compound has the structure of Formula (I), Formula (l-A-i), or Formula (l-A-ii), and R8and R9are not selected from F, Cl, Br, and I, that is, neither R8nor R9solely consists of halo.

[0158] In some embodiments, R8includes an alkyl moiety (e.g., optionally substituted Ci- C6alkyl). In some embodiments, the alkyl moiety of R8is Ci-C6alkyl. In some embodiments, the alkyl moiety of R8is Ci-C5alkyl. In some embodiments, the alkyl moiety of R8is Ci-C4alkyl. In some embodiments, the alkyl moiety of R8is Ci-C3alkyl. In some embodiments, the alkyl moiety of R8is Ci-C2alkyl. In some embodiments, the alkyl moiety of RBis Cz-CealkyL In some embodiments, the alkyl moiety of R8is C2-Csalkyl. In some embodiments, the alkyl moiety of R8is C2-C4alkyl. In some embodiments, the alkyl moiety of R8is C2-C3alkyl. In some embodiments, the alkyl moiety of R8is C3-C6alkyl. In some embodiments, the alkyl moiety of R8is C3-C5alkyl. In some embodiments, the alkyl moiety of R8is C3-C4alkyl. In some embodiments, the alkyl moietyof R8is Czi-Cealkyl. In some embodiments, the alkyl moiety of Rais C^CsalkyL In some embodiments, the alkyl moiety of R8is Cs-Cealkyl.

[0159] In some embodiments, the alkyl moiety of R8is selected from Ci-Cealkyl, Ci- Cedeuteroalkyl, C-i-Cehaloalkyl, and Ci-Cedeuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R8are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R8are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R8is unsubstituted Ci-CealkyL In some embodiments, the alkyl moiety of R8is substituted Ci-Csalkyl. In some embodiments, the alkyl moiety of R8is substituted with one or more substituents independently selected from OH and Ci-CsalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0160] In some embodiments, R8is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R8is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3ICH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3ICH2CH2CHD2ICH2CH2CDH2ICH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)21CH(CD3)2ICH(CHD2)2ICH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)31C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)21CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3ICH2CH(CH3)CH3ICH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3Jand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R8is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2ICF3ICH2CH3, CD2CD3, CF2CF3, CH(CH3)2ICH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3IC(CD3)3Iand C(CF3)3Jincluding any member, combination, or subset thereof. In some embodiments, R8is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R8is selected from CH3, CD31CH2CH3, and CH(CH3)2, including any member, combination, or subset thereof.

[0161] In some embodiments, R8is Cs-CscycloalkyL In some embodiments, R8is cyclopropyl. In some embodiments, R8is cyclobutyl. In some embodiments, R8is cyclopentyl. In some embodiments, R8is selected from cyclopropyl, cyclobutyl, and cyclopentyl, including any member, combination, or subset thereof.

[0162] In some embodiments, the cycloalkyl moiety of R8is selected from C3-Cscycloalkyl, C1- Cs-Csdeuterocycloalkyl, Cs-Cshalocycloalkyl, and Cs-Csdeuterohalocycloalkyl, including anymember, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the cycloalkyl moiety of R8are replaced by a halogen atom and none of the available atoms of the cycloalkyl moiety of R8are replaced by an alternative isotope thereof. In some embodiments, the cycloalkyl moiety of R8is unsubstituted C Cscycloalkyl. In some embodiments, the cycloalkyl moiety of R8is substituted Ca-Cscycloalkyl. In some embodiments, the cycloalkyl moiety of R8is substituted with one or more substituents independently selected from OH and Ci- CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0163] In some embodiments, R8includes at least one deuterium atom. In some embodiments, R8includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of Ci-Cealkyl and / or Ca-Cscycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-Cealkyl and / or C3-C5cycloalkyl of Raare optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of C-i-Cealkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-Cealkyl and / or C3-Cscycloalkyl of R8are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of Ci-Cealkyl and / or C3-Cscycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of C C6alkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-Cealkyl and / or C3-C5cycloalkyl of RBare optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In someembodiments, one or more available hydrogen atoms of Ci-Cealkyl and / or Cs-Cscycloalkyl of R8are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of Ci-Csalkyl and / or C3-C5cycloalkyl of R8are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of Ci-Cealkyl and / or Ca-Cscycloalkyl of R8are replaced with a halogen atom. In some embodiments, none of the available atoms of Ci- Cealkyl and / or Ca-Cscycloalkyl of R8are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of Ci-Cealkyl and / or C3-C5cycloalkyl of R8are replaced with a halogen atom and none of the available atoms of Ci-Cealkyl and / or C3- Cscycloalkyl of R8are replaced with an alternative isotope thereof.

[0164] In some embodiments, R8and R9are the same. In some embodiments, R8and R9are different.

[0165] In some embodiments, R9is selected from H, D, and optionally substituted Ci-C6alkyl, including any member, combination, or subset thereof, wherein R9is not selected from F, Cl, Br, and I, that is, R9does not solely consist of halo. In some embodiments, R9is selected from H not replaced with a halogen atom or D, including any member, combination, or subset thereof. In some embodiments, R9is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R9is D.

[0166] In some embodiments, R9includes an alkyl moiety (e.g., optionally substituted C1- C6alkyl). In some embodiments, the alkyl moiety of R9is Ci-C6alkyl. In some embodiments, the alkyl moiety of R9is Ci-C5alkyl. In some embodiments, the alkyl moiety of R9is Ci-C4alkyl. In some embodiments, the alkyl moiety of R9is Ci-Csalkyl. In some embodiments, the alkyl moiety of R9is Ci-CzalkyL In some embodiments, the alkyl moiety of R9is Cz-CealkyL In some embodiments, the alkyl moiety of R9is Cj-Csalkyl. In some embodiments, the alkyl moiety of R9is C2-C4alkyl. In some embodiments, the alkyl moiety of R9is C2-C3alkyl. In some embodiments, the alkyl moiety of R9is C3-C6alkyl. In some embodiments, the alkyl moiety of R9is C3-C5alkyl. In some embodiments, the alkyl moiety of R9is C3-C4alkyl. In some embodiments, the alkyl moiety of R9is C4-C6alkyl. In some embodiments, the alkyl moiety of R9is C4-Csalkyl. In some embodiments, the alkyl moiety of R9is Cs-CgalkyL

[0167] In some embodiments, the alkyl moiety of R9is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R9are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R9are replaced by analternative isotope thereof. In some embodiments, the alkyl moiety of R9is unsubstituted Ci- Cealkyl. In some embodiments, the alkyl moiety of R9is substituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R9is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e g., CH2OH), including any member, combination, or subset thereof.

[0168] In some embodiments, R9is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R9is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF31CH2CH2CHD2, CH2CH2CDH2ICH2CH2CD3ICH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2|CH(CD3)2ICH(CHD2)2ICH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2ICH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3ICH2C(CH3)3, CH2C(CF3)3ICH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R9is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF21CF31CH2CH3, CD2CD3, CF2CF3ICH(CH3)2ICH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R9is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)31including any member, combination, or subset thereof. In some embodiments, R9is selected from H, D, CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R9is selected from H, D, CH3, CD31CH2CH3, and CH(CH3)2, including any member, combination, or subset thereof.

[0169] In some embodiments, R9is C3-C5cycloalkyl. In some embodiments, R9is cyclopropyl. In some embodiments, R9is cyclobutyl. In some embodiments, R9is cyclopentyl. In some embodiments, R9is selected from cyclopropyl, cyclobutyl, and cyclopentyl, including any member, combination, or subset thereof.

[0170] In some embodiments, the cycloalkyl moiety of R9is selected from Cs-Cscycloalkyl, C1- Cs-Csdeuterocycloalkyl, Cs-Cshalocycloalkyl, and C3-C5deuterohalocycloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the cycloalkyl moiety of R9are replaced by a halogen atom and none of the available atoms of the cycloalkyl moiety of R9are replaced by an alternative isotope thereof. In some embodiments, the cycloalkyl moiety of R9is unsubstituted C3-C5cycloalkyl. In some embodiments,the cycloalkyl moiety of R9is substituted Ca-Cscycloalkyl. In some embodiments, the cycloalkyl moiety of R9is substituted with one or more substituents independently selected from OH and Ci- CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0171] In some embodiments, R9includes at least one deuterium atom. In some embodiments, C Cealkyl and / or Ca-Cscycloalkyl of R9includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of CrCealkyl and / or Ce-Cecycloalkyl of R9are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of CrCealkyl and / or Ce-Cscycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of CrCealkyl and / or C3- Cscycloalkyl of R9are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of CrCealkyl and / or Ca-Cscycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of CrC6alkyl and / or C3-C5cycloalkyl of R9are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of CrCealkyl and / or C3- Cscycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Cr Cealkyl and / or Cs-Cscycloalkyl of R9are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and / or C3- Cscycloalkyl of R9are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of CrCealkyl and / or C3-Cscycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and / or C3-C5cycloalkyl of R9are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of C C6alkyl and / or C3-C5cycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of CrCealkyl and / or Cs-Cscycloalkyl of R9are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of C C6alkyl and / or C3-C5cycloalkyl of R9are optionally and independently replaced with one or more respective alternative isotopes thereof. In someembodiments, none of the available hydrogen atoms of Ci-Cealkyl and / or Cs-Cscycloalkyl of R9are replaced with a halogen atom. In some embodiments, none of the available atoms of Ci- Cealkyl and / or Ca-Cscycloalkyl of R9are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of Ci-Cealkyl and / or C3-C5cycloalkyl of R9are replaced with a halogen atom and none of the available atoms of C-i-Cealkyl and / or C3- Cscycloalkyl of R9are replaced with an alternative isotope thereof.

[0172] In some embodiments, R10is selected from H, D, halogen, and optionally substituted C1- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R10is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R10is halo. In some embodiments, R10is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R10is a halogen selected from fluorine and bromine. In some embodiments, R10is a halogen selected from fluorine and chlorine. In some embodiments, R10is a halogen selected from chlorine and bromine. In some embodiments, R10is fluorine. In some embodiments, R10is chlorine. In some embodiments, R10is bromine. In some embodiments, R10is iodine. In some embodiments, R10is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R10is D.

[0173] In some embodiments, R10includes an alkyl moiety (e.g., optionally substituted C1- Cealkyl). In some embodiments, the alkyl moiety of R10is Ci-Cgalkyl. In some embodiments, the alkyl moiety of R10is Ci-Csalkyl. In some embodiments, the alkyl moiety of R10is Ci-C4alkyl. In some embodiments, the alkyl moiety of R10is Ci-Caalkyl . In some embodiments, the alkyl moiety of R10is Ci-C2alkyl. In some embodiments, the alkyl moiety of R10is Cz-Cealkyl. In some embodiments, the alkyl moiety of R10is Cz-Csalkyl. In some embodiments, the alkyl moiety of R10is C2-C4alkyl. In some embodiments, the alkyl moiety of R10is C2-C3alkyl. In some embodiments, the alkyl moiety of R10is Ca-Cealkyl. In some embodiments, the alkyl moiety of R10is Cs-Csalkyl. In some embodiments, the alkyl moiety of R10is C3-C4alkyl. In some embodiments, the alkyl moiety of R10is C4-Cealkyl. In some embodiments, the alkyl moiety of R10is C4-Csalkyl. In some embodiments, the alkyl moiety of R10is Cs-Csalkyl.

[0174] In some embodiments, the alkyl moiety of R1° is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R10are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R10are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R10is unsubstituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R10is substituted Ci-CealkyL In some embodiments, the alkyl moiety of R10is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0175] In some embodiments, R10is optionally substituted Ci-Cealkyl. In some embodiments, R10is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof

[0176] In some embodiments, R10is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF31CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)31CH2CH2C(CF3)31and CHzCH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R10is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R10is selected from CH3, CHF2, CF3JCD3ICH2CH3JCH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R10is selected from H, D, F, CH3, CH2D, CHD2, CD3ICH2F, CHF2ICF3ICHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0177] In some embodiments, R10includes at least one deuterium atom. In some embodiments, R10includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R10are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R10are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R10are optionally andindependently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R10are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R10are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R10are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R10are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R10are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R10are replaced with a halogen atom. In some embodiments, none of the available atoms of R10are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R10are replaced with a halogen atom and none of the available atoms of R10are replaced with an alternative isotope thereof.

[0178] In some embodiments, R11is selected from H, D, halogen, and optionally substituted Ci- C6alkyl, including any member, combination, or subset thereof. In some embodiments, R11is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R11is halo. In some embodiments, R11is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R11is a halogen selected from fluorine and bromine. In some embodiments, R11is a halogen selected from fluorine and chlorine. In some embodiments, R11is a halogen selected from chlorine and bromine. In some embodiments, R11is fluorine. In some embodiments, R11is chlorine. In some embodiments, R11is bromine. In some embodiments, R11is iodine. In some embodiments, R11is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R11is D. In some embodiments R10and R11are the same as one another. In some embodiments, R10and R11are different from one another.

[0179] In some embodiments, R11includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R11is Ci-Cealkyl. In some embodiments, the alkyl moiety of R11is Ci-Csalkyl. In some embodiments, the alkyl moiety of R11is Ci-C4alkyl. In some embodiments, the alkyl moiety of R11is Ci-C3alkyl. In some embodiments, the alkyl moiety of R11is Ci-C2alkyl. In some embodiments, the alkyl moiety of R11is C2-Cealkyl. In some embodiments, the alkyl moiety of R11is C2-C5alkyl. In some embodiments, the alkyl moiety of R11is C2-C4alkyl. In some embodiments, the alkyl moiety of R11is C2-C3alkyl. In some embodiments, the alkyl moiety of R11is Cs-Cealkyl. In some embodiments, the alkyl moiety of R11is C3-Csalkyl. In some embodiments, the alkyl moiety of R11is C3-C4alkyl. In some embodiments, the alkyl moiety of R11is C4-Cealkyl. In some embodiments, the alkyl moiety of R11is C4-C5alkyl. In some embodiments, the alkyl moiety of R11is Cs-Cealkyl.

[0180] In some embodiments, the alkyl moiety of R11is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R11are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R11are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R11is unsubstituted C-i- C6alkyl. In some embodiments, the alkyl moiety of R11is substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R11is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0181] In some embodiments, R11is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R11is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF31CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3ICH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3IC(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)31CH2CH2C(CF3)3Iand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R11is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R11isselected from CH3, CHF2, CF3, CD3]CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R11is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2JCF3JCHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0182] In some embodiments, R11includes at least one deuterium atom. In some embodiments, R11includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R11are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R11are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R11are replaced with a halogen atom. In some embodiments, none of the available atoms of R11are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R11are replaced with a halogen atom and none of the available atoms of R11are replaced with an alternative isotope thereof.

[0183] In some embodiments,togetherform a carbonyl group having a structureover a bond means that the bond is attached to a remaining portion of the compound.

[0184] In some embodiments, R12is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R12is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R12is halo. In some embodiments, R1Zis a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R12is a halogen selected from fluorine and bromine. In some embodiments, R12is a halogen selected from fluorine and chlorine. In some embodiments, R12is a halogen selected from chlorine and bromine. In some embodiments, R12is fluorine. In some embodiments, R12is chlorine. In some embodiments, R12is bromine. In some embodiments, R12is iodine. In some embodiments, R12is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R12is D.

[0185] In some embodiments, R12includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R12is Ci-Cealkyl. In some embodiments, the alkyl moiety of R12is Ci-CsalkyL In some embodiments, the alkyl moiety of R12is Ci-C4alkyl. In some embodiments, the alkyl moiety of R12is Ci-Csalkyl. In some embodiments, the alkyl moiety of R12is Ci-C2alkyl. In some embodiments, the alkyl moiety of R12is Cz-CealkyL In some embodiments, the alkyl moiety of R12is Cz-Csalkyl. In some embodiments, the alkyl moiety of R12is C2-C4alkyl. In some embodiments, the alkyl moiety of R12is C2-C3alkyl. In some embodiments, the alkyl moiety of R12is Cs-Cealkyl. In some embodiments, the alkyl moiety of R12is Cs-Csalkyl. In some embodiments, the alkyl moiety of R12is C3-C4alkyl. In some embodiments, the alkyl moiety of R12is C4-Cealkyl. In some embodiments, the alkyl moiety of R12is C4-Csalkyl. In some embodiments, the alkyl moiety of R12is Cs-Cgalkyl.

[0186] In some embodiments, the alkyl moiety of R12is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In someembodiments, none of the available hydrogen atoms of the alkyl moiety of R12are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R12are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R12is unsubstituted Ci- CealkyL In some embodiments, the alkyl moiety of R12is substituted CrCealkyl. In some embodiments, the alkyl moiety of R12is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0187] In some embodiments, R12is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R12is selected from CH3, CD2H, CDH2ICD3ICF2H, CFH2, CF3ICH2CH3, CH2CH2F, CH2CF2H, CH2CF3ICF2CF3ICH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2JCH(CDH2)2IC(CH3)3IC(CF3)3IC(CHF2)3IC(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)21CH2CH(CD3)2, CH2CH(CF3)2>CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3ICH2CH(CH3)CD3, CH2C(CH3)3ICH2C(CF3)3ICH2C(CD3)3ICH2CH2C(CH3)3, CH2CH2C(CF3)3Jand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R12is selected from CH3, CH2D, CHD2, CD31CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3JCH(CH3)2JCH(CD3)2JCH(CF3)2ICD(CD3)21CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R12is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R12is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0188] In some embodiments, R12includes at least one deuterium atom. In some embodiments, R12includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof.In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R12are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R12are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R12are replaced with a halogen atom. In some embodiments, none of the available atoms of R12are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R12are replaced with a halogen atom and none of the available atoms of R12are replaced with an alternative isotope thereof.

[0189] In some embodiments, R13is selected from H, D, halogen, and optionally substituted Ci-C6alkyl, including any member, combination, or subset thereof. In some embodiments, R13is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R13is halo. In some embodiments, R13is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R13is a halogen selected from fluorine and bromine. In some embodiments, R13is a halogen selected from fluorine and chlorine. In some embodiments, R13is a halogen selected from chlorine and bromine. In some embodiments, R13is fluorine. In some embodiments, R13is chlorine. In some embodiments, R13is bromine. In some embodiments, R13is iodine. In some embodiments, R13is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R13is D. In some embodiments R12and R13are the same as one another. In some embodiments, R12and R13are different from one another.

[0190] In some embodiments, R13includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R13is Ci-Cealkyl. In some embodiments, the alkyl moiety of R13is Ci-Csalkyl. In some embodiments, the alkyl moiety of R13is Ci-C4alkyl. In some embodiments, the alkyl moiety of R13is Ci-C3alkyl. In some embodiments, the alkyl moiety of R13is Ci-C2alkyl. In some embodiments, the alkyl moiety of R13is C2-Cealkyl. In some embodiments, the alkyl moiety of R13is C2-C5alkyl. In some embodiments, the alkyl moiety of R13is C2-C4alkyl. In some embodiments, the alkyl moiety of R13is C2-C3alkyl. In some embodiments, the alkyl moiety of R13is Cs-Cealkyl. In some embodiments, the alkyl moiety of R13is C3-Csalkyl. In some embodiments, the alkyl moiety of R13is C3-C4alkyl. In some embodiments, the alkyl moiety of R13is C4-Cealkyl. In some embodiments, the alkyl moiety of R13is C4-C5alkyl. In some embodiments, the alkyl moiety of R13is Cs-Cealkyl.

[0191] In some embodiments, the alkyl moiety of R13is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R13are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R13are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R13is unsubstituted C-i- C6alkyl. In some embodiments, the alkyl moiety of R13is substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R13is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0192] In some embodiments, R13is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R13is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3]CH2CH2F, CH2CF2H, CH2CF3, CF2CF31CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3ICH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3JCH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)31CH2CH2C(CF3)3Iand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R13is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R13isselected from CH3, CHF2, CF3, CD3]CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R13is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2JCF3JCHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0193] In some embodiments, R13includes at least one deuterium atom. In some embodiments, R13includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R13are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R13are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R13are replaced with a halogen atom. In some embodiments, none of the available atoms of R13are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R13are replaced with a halogen atom and none of the available atoms of R13are replaced with an alternative isotope thereof.

[0194] In some embodiments, R10and R11are H, and R12and R13are D. In some embodiments, R10and R11are D, and R12and R13are H. In some embodiments, R10, R11, R12, and R13are each H. In some embodiments, R10, R11, R12, and R13are each D.

[0195] In some embodiments,together form a carbonyl group having a structureover a bond means that the bond is attached to a remaining portion of the compound. In some embodiments, R10and R11together form a first carbonyl group and R12and R13together form a second carbonyl group in the same compound.

[0196] In some embodiments Q is selected as Q1 , wherein R2-R4and R7are H, to provide a compound having a structure of Formula (l-A-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from cyclopropyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, OH, OCH3, OCHF2, O-cyclopentyl, OC(O)(CH2)2C(O)OH, OC(O)(CH2)3C(O)OH, O-tetrahydrofuranyl, OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, SCH3, SCF3, SC(O)(CH2)3C(O)OH, S(O)CH3, S(O)2CH3, andR8is selected from CH3, CD3, CH2CH3, and CH(CH3)2;R9is selected from H, CH3, CD3, CH2CH3)and CH(CH3)2;R10is selected from H and D;R11is selected from H and D;R1Zis selected from H, D, and CH3;R13is selected from H and D; and none of the available hydrogen atoms of R1, Rz, R3, R4, R5, R6, R7, R8, R9, R10, R11, R1Z, and R13are replaced with respective halogen atoms and none of the available atoms of R1, Rz, R3, R4, R5, R6, R7, R8, R9, R10, R11, R1Z, and R13are replaced with respective alternative isotopes thereof.

[0197] In some embodiments Q is selected as Q2 to provide a compound having the structure of Formula (l-B-i):wherein Xa, Xb, R1, Rz, R3, R4, R5, R6, R7, R14, R15, R16, R17, and k are as defined (and provisos and exclusions provided for) herein.

[0198] In some embodiments, when Q is selected as Q2, a compound is provided having the structure of Formula (I), Formula (l-B-i), or Formula (l-B-ii), wherein none of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, R16, and R17are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, R7, R16, and R17are replaced with respective alternative isotopes thereof.

[0199] In some embodiments, the compound has the structure of Formula (I) or Formula (l-B- i), and R14is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, and R15is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, including any member, combination, or subset thereof.

[0200] In some embodiments, R14is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R14is halo. In some embodiments, R14is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R14is a halogen selected from fluorine and bromine. In some embodiments, R14is a halogen selected from fluorine and chlorine. In some embodiments, R14is a halogen selected from chlorine and bromine. In some embodiments, R14is fluorine. In some embodiments, R14is chlorine. In some embodiments, R14is bromine. In some embodiments, R14is iodine. In some embodiments, R14is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R14is D.

[0201] In some embodiments, R14includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R14is Ci-Cealkyl. In some embodiments, the alkyl moiety of R14is Ci-Csalkyl. In some embodiments, the alkyl moiety of R14is Ci-C4alkyl. In some embodiments, the alkyl moiety of R14is Ci-Csalkyl. In some embodiments, the alkyl moiety of R14is Ci-Czalkyl. In some embodiments, the alkyl moiety of R14is Cz-Cealkyl. In some embodiments, the alkyl moiety of R14is C2-C5alkyl. In some embodiments, the alkyl moiety of R14is C2-C4alkyl. In some embodiments, the alkyl moiety of R14is C2-C3alkyl. In some embodiments, the alkyl moiety of R14is Cs-Cealkyl. In some embodiments, the alkyl moiety of R14is Cs-Csalkyl. In some embodiments, the alkyl moiety of R14is C3-C4alkyl. In some embodiments, the alkyl moiety of R14is C4-C6alkyl. In some embodiments, the alkyl moiety of R14is C4-Csalkyl. In some embodiments, the alkyl moiety of R14is Cs-Cealkyl.

[0202] In some embodiments, the alkyl moiety of R14is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R14are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R14are replaced by analternative isotope thereof. In some embodiments, the alkyl moiety of R14is unsubstituted Ci- Cealkyl. In some embodiments, the alkyl moiety of R14is substituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R14is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0203] In some embodiments, R14is optionally substituted Ci-Cealkyl. In some embodiments, R14is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0204] In some embodiments, R14is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD31CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3ICH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3ICH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R14is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH31CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R14is selected from CH31CHF2, CF3JCD3ICH2CH3ICH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R14is selected from H, D, F, CH3, CH2D, CHD2, CD3ICH2F, CHF2ICF3ICHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0205] In some embodiments, R14includes at least one deuterium atom. In some embodiments, R14includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof.In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R14are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R14are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R14are replaced with a halogen atom. In some embodiments, none of the available atoms of R14are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R14are replaced with a halogen atom and none of the available atoms of R14are replaced with an alternative isotope thereof.

[0206] In some embodiments, R15is selected from H, D, halogen, and optionally substituted Ci- C6alkyl, including any member, combination, or subset thereof. In some embodiments, R15is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R15is halo. In some embodiments, R15is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R15is a halogen selected from fluorine and bromine. In some embodiments, R15is a halogen selected from fluorine and chlorine. In some embodiments, R15is a halogen selected from chlorine and bromine. In some embodiments, R15is fluorine. In some embodiments, R15is chlorine. In some embodiments, R15is bromine. In some embodiments, R15is iodine. In some embodiments, R15is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R15is D. In some embodiments R14and R15are the same as one another. In some embodiments, R14and R15are different from one another.

[0207] In some embodiments, R15includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R15is Ci-Cealkyl. In some embodiments, the alkyl moiety of R15is Ci-Csalkyl. In some embodiments, the alkyl moiety of R15is Ci-C4alkyl. In some embodiments, the alkyl moiety of R15is C-i-Caalkyl. In some embodiments, the alkyl moiety of R15is Ci-C2alkyl. In some embodiments, the alkyl moiety of R15is C2-Cealkyl. In some embodiments, the alkyl moiety of R15is C2-C5alkyl. In some embodiments, the alkyl moiety of R15is C2-C4alkyl. In some embodiments, the alkyl moiety of R15is C2-C3alkyl. In some embodiments, the alkyl moiety of R15is Cs-Cealkyl. In some embodiments, the alkyl moiety of R15is Cs-Csalkyl. In some embodiments, the alkyl moiety of R15is C3-C4alkyl. In some embodiments, the alkyl moiety of R15is C4-Cealkyl. In some embodiments, the alkyl moiety of R15is C4-C5alkyl. In some embodiments, the alkyl moiety of R15is Cs-Cealkyl.

[0208] In some embodiments, the alkyl moiety of R15is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R15are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R15are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R15is unsubstituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R15is substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R15is substituted with one or more substituents independently selected from OH and Ci-CgalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0209] In some embodiments, R15is optionally substituted Ci-Cgalkyl. In some embodiments, R15is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0210] In some embodiments, R15is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD31CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3IC(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R15is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3,CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)21CF(CF3)2, C(CH3)31C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R15is selected from CH3, CHF2, CF3JCD3, CH2CH3, CH(CH3)2JCH(CD3)2Jand C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R15is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2ICF3ICHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0211] In some embodiments, R15includes at least one deuterium atom. In some embodiments, R15includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R15are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R15are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R15are replaced with a halogen atom. In some embodiments, none of the available atoms of R15are replaced with an alternative isotope thereof. In some embodiments, none of theavailable hydrogen atoms of R15are replaced with a halogen atom and none of the available atoms of R15are replaced with an alternative isotope thereof.

[0212] In some embodiments, R14and R15are H. In some embodiments, R14and R15are D. In some embodiments, R14is H and R15is D.

[0213] In some embodiments, R14and R15(i.e.,J togetherform a carbonyl group having a structure** over a bond means that the bond is attached to a remaining portion of the compound.

[0214] In some embodiments, R16is selected from H, D, optionally substituted Ci-Csalkyl, and optionally substituted Ci-C6alkyleneOCi-C6alkyl, including any member, combination, or subset thereof, wherein R16is not selected from F, Cl, Br, and I, that is, R16does not solely consist of halo. In some embodiments, R16is selected from H not replaced with a halogen atom, Ci-Csalkyl, and CH2CH2OCH3, including any member, combination, or subset thereof. In some embodiments, R16is selected from H not replaced with a halogen atom and D, including any member, combination, or subset thereof. In some embodiments, R16is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R16is D.

[0215] In some embodiments, R16includes an alkyl moiety (e.g., optionally substituted Ci- C6alkyl and optionally substituted Ci-C6alkyleneOCi-CBalkyl). In some embodiments, the alkyl moiety of R16is independently Ci-Cealkyl. In some embodiments, the alkyl moiety of R16is independently Ci-Csalkyl. In some embodiments, the alkyl moiety of R1Bis independently Cr C4alkyl. In some embodiments, the alkyl moiety of R16is independently Ci-Caalkyl. In some embodiments, the alkyl moiety of R16is independently Ci-C2alkyl. In some embodiments, the alkyl moiety of R16is independently C2-CEalkyl. In some embodiments, the alkyl moiety of R16is independently C2-Csalkyl. In some embodiments, the alkyl moiety of R16is independently C2- C4alkyl. In some embodiments, the alkyl moiety of R16is independently C2-C3alkyl. In some embodiments, the alkyl moiety of R16is independently Cs-Cealkyl. In some embodiments, the alkyl moiety of R16is independently Cs-Csalkyl. In some embodiments, the alkyl moiety of R16is independently C3-C4alkyl. In some embodiments, the alkyl moiety of R16is independently C4-Cealkyl. In some embodiments, the alkyl moiety of R16is independently C -CsalkyL In some embodiments, the alkyl moiety of R16is independently Cs-Cgalkyl.

[0216] In some embodiments, the alkyl moiety of R16is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R16are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R16are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R16is independently unsubstituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R16is independently substituted C-i-Cealkyl. In some embodiments, the alkyl moiety of R16is substituted with one or more substituents independently selected from OH and Ci-CsalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0217] In some embodiments, the alkylene moiety of R16(e.g., optionally substituted C1- CgalkyleneOCi-Csalkyl) is C-i-Cgalkylene. In some embodiments, the alkylene moiety of R16is C1- Csalkylene. In some embodiments, the alkylene moiety of R16is Ci-C4alkylene. In some embodiments, the alkylene moiety of R16is Ci-C3alkylene. In some embodiments, the alkylene moiety of R16is Ci-C2alkylene. In some embodiments, the alkylene moiety of R16is C2-Cealkylene. In some embodiments, the alkylene moiety of R16is C2-C5alkylene. In some embodiments, the alkylene moiety of R16is C2-C4alkylene. In some embodiments, the alkylene moiety of R16is C2- C3alkylene. In some embodiments, the alkylene moiety of R16is C3-C6alkylene. In some embodiments, the alkylene moiety of R16is Cs-Csalkylene. In some embodiments, the alkylene moiety of R16is C3-C4alkylene. In some embodiments, the alkylene moiety of R16is C4-C6alkylene. In some embodiments, the alkylene moiety of R16is C4-Csalkylene. In some embodiments, the alkylene moiety of R16is Cs-Cealkylene.

[0218] In some embodiments, the alkylene moiety of R16is selected from alkylene, deuteroalkylene, haloalkylene, and deuterohaloalkylene, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkylene moiety of R16are replaced by a halogen atom and none of the available atoms of the alkylene moiety of R16are replaced by an alternative isotope thereof. In some embodiments, the alkylene moiety of R16is unsubstituted Ci-Csalkylene. In some embodiments, the alkylene moiety of R16is substituted Ci-Csalkylene.

[0219] In some embodiments, R16is optionally substituted Ci-Cgalkyl. In some embodiments, R16is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0220] In some embodiments, R1Bis selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF31CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3|CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2,CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R1Bis selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2ICF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R16is selected from CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R16is selected from H, D, CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R16is selected from H, D, CH3, CD3, CH2CH3, and CH(CH3)2, including any member, combination, or subset thereof. In some embodiments, R1Bis CH2CH2OCH. In some embodiments, R16is selected from H, CH3, and CH2CH2OCH3.

[0221] In some embodiments, R16includes at least one deuterium atom. In some embodiments, optionally substituted C-i-Cealkyl and optionally substituted Ci-CgalkyleneOCi-Csalkyl of R1Bincludes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and Ci-C6alkyleneOCi-CBalkyl of R1Bare optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R1Bare optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R1Bare optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R16are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R1Bare optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R16are optionally and independently replaced with one or more respective alternative isotopes thereof. In someembodiments, one or more available hydrogen atoms of optionally substituted Ci-Cealkyl and optionally substituted Ci-CsalkyleneOCi-Csalkyl of R16are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R16are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted C-i-CsalkyleneOCi-Cgalkyl of R16are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R16are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted CrCgalkyleneOCi-Cealkyl of R1Bare optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R16are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted Ci-C6alkyleneOCi-C6alkyl of R16are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R16are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted Ci-CgalkyleneOCi-Cgalkyl of R16are replaced with a halogen atom. In some embodiments, none of the available atoms of R16are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted Ci-C6alkyleneOCi- Cealkyl of R16are replaced with a halogen atom and none of the available atoms of R16are replaced with an alternative isotope thereof.

[0222] In some embodiments, R17is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC-i-Cgalkyl, SH, and optionally substituted SCi-Cgalkyl, including any member, combination, or subset thereof.

[0223] In some embodiments, R17is halogen, i.e., selected from F, Cl, Br, and I, including any member, combination, or subset thereof). In some embodiments, R17is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R17is a halogen selected from fluorine and bromine. In some embodiments, R17is a halogen selected from fluorine and chlorine. In some embodiments, R17is a halogen selected from chlorine and bromine. In some embodiments, R17is fluorine. In some embodiments, R17is chlorine. In some embodiments, R17is bromine. In some embodiments, R17is iodine. In some embodiments, R17is not halogen.

[0224] In some embodiments, R17includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl, optionally substituted OCi-Cealkyl, and optionally substituted SCi-Cealkyl). In some embodiments, each alkyl moiety of R17is independently Ci-Cealkyl. In some embodiments, each alkyl moiety of R17is independently Ci-C$alkyl. In some embodiments, each alkyl moiety of R17is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R17is independently C-i- C3alkyl. In some embodiments, each alkyl moiety of R17is independently Ci-C2alkyl. In some embodiments, each alkyl moiety of R17is independently Cz-Cealkyl. In some embodiments, each alkyl moiety of R17is independently C2-C5alkyl. In some embodiments, each alkyl moiety of R17is independently Cj-C^alkyl. In some embodiments, each alkyl moiety of R17is independently C2- C3alkyl. In some embodiments, each alkyl moiety of R17is independently Ca-Cealkyl. In some embodiments, each alkyl moiety of R17is independently Ca-Csalkyl. In some embodiments, each alkyl moiety of R17is independently C3-C4alkyl. In some embodiments, each alkyl moiety of R17is independently C -Cealkyl. In some embodiments, each alkyl moiety of R17is independently C4- Csalkyl. In some embodiments, each alkyl moiety of R17is independently Cs-Cealkyl.

[0225] In some embodiments, the alkyl moiety of R17(e.g., optionally substituted Ci-C6alkyl, optionally substituted OCi-C6alkyl, and optionally substituted SCi-C6alkyl) is independently selected from Ci-C6alkyl, CrC6deuteroalkyl, Ci-C6haloalkyl, and Ci-C6deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R17are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R17are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R17is independently unsubstituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R17is independently substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R17is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof. In some embodiments, the alkyl moiety of R17has one or more hydrogen atoms independently replaced by one or more respective halogen atoms and / or one or more atoms replaced by one or more respective alternative isotopes thereof.

[0226] In some embodiments, R17is optionally substituted Ci-Cealkyl. In some embodiments, R17is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0227] In some embodiments, R17is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2,CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R17is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0228] In some embodiments, R17is selected from OH and optionally substituted OCi-Cealkyl. In some embodiments, R17is selected from OH, OD, optionally substituted OCi-Cealkyl., including any member, combination, or subset thereof. In some embodiments, R17is selected from OH, OD, OCH3, OCH2D, OCHD2, OCD3, OCH2F, OCHF2, OCF3, OCH2CH3, OCD2CD3, OCF2CF3IOCH(CH3)2, OCH(CD3)2, OCH(CF3)2, OCD(CD3)2, OCF(CF3)2, OC(CH3)3, OC(CD3)3, and OC(CF3)3, including any member, combination, or subset thereof. In some embodiments, R17is selected from OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, and OCD3, including any member, combination, or subset thereof. In some embodiments, R17is selected from OH, OCH3, OCHF2, and OCF3.

[0229] In some embodiments, R17is selected from SH and optionally substituted SCi-Cealkyl. In some embodiments, R17is selected from SH, SD, optionally substituted SCi-Cealkyl, including any member, combination, or subset thereof. In some embodiments, R17is selected from SH, SD, SCH2F, SCHF2, SCF3, SCH2D, SCHD2, and SCD3, including any member, combination, or subset thereof.

[0230] In some embodiments, R17is selected from F, optionally substituted Ci-C3alkyl, OH, optionally substituted OCi-C3alkyl, SH, and optionally substituted SCi-C3alkyl, including any member, combination, or subset thereof. In some embodiments, R17is selected from CH3, CH2D, CHD2, CD3JCH2F, CHF2, CF3, CHDF, CD2F, CDF2, OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, OCD3ISH, SCH2F, SCHF2, SCF3, SD, SCH2D, SCHD2, and SCD3, wherein none of the available hydrogen atoms of R17are replaced with respective halogen atoms and none of the available atoms of R17are replaced with respective alternative isotopes thereof.

[0231] In some embodiments, R17includes at least one deuterium atom. In some embodiments, R17includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R17are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R17are optionally andindependently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R17are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R17are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R17are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R17are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R17are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R17are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R17are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R17are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R17are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R17are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R17are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R17are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R17are replaced with a halogen atom. In some embodiments, none of the available atoms of R17are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R17are replaced with a halogen atom and none of the available atoms of R17are replaced with an alternative isotope thereof.

[0232] In some embodiments, k is selected from 0 and 1 . In some embodiments, k is 0. In some embodiments, k is 1.

[0233] In some embodiments Q is selected as Q2, wherein R2, R3, R4, R7, R14, and R15are H, and k is 0, to provide a compound having the structure of Formula (l-B-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from OH, OCH3, OCHF2, OC(O)CH31OC(O)(CH2)2C(O)OH, OC(O)(CH2)3C(O)OH,OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH3, OP(O)(OH)2, SCH3, andR16is selected from H, CH3, and CH2CH2OCH3; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

[0234] In some embodiments Q is selected as Q3 to provide a compound having the structure of Formula (l-C-i):(l-C-i), wherein Xa, Xb, R1, R2, R3, R4, R5, RB, R7, R1B, R19, R20, R21, R22, and m are as defined (and provisos and exclusions provided for) herein.

[0235] In some embodiments, when Q is selected as Q3, a compound is provided having the structure of Formula (I), Formula (l-C-i), or Formula (l-C-ii), wherein none of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, and R22are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, R7, and R22are replaced with respective alternative isotopes thereof.

[0236] In some embodiments, the compound has the structure of Formula (I) or Formula (l-C- i), and R18is selected from H, D, halogen, and optionally substituted Ci-C6alkyl, including any member, combination, or subset thereof. In some embodiments, R1Bis selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R18is halo. In some embodiments, R1Bis a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R18is a halogen selected from fluorine and bromine. In some embodiments, R18is a halogen selected from fluorine and chlorine. In some embodiments, R18is a halogen selected from chlorine and bromine. In some embodiments, R18is fluorine. In some embodiments, R18is chlorine. In some embodiments, R1Bis bromine. In some embodiments, R18is iodine. In some embodiments, R18is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R18is D.

[0237] In some embodiments, R18includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R18is Ci-Cealkyl. In some embodiments, the alkyl moiety of R18is Ci-Csalkyl. In some embodiments, the alkyl moiety of R18is Ci-C4alkyl. In some embodiments, the alkyl moiety of R18is Ci-C3alkyl. In some embodiments, the alkyl moiety of R18is Ci-C2alkyl. In some embodiments, the alkyl moiety of R18is C2-Cealkyl. In some embodiments, the alkyl moiety of R18is C2-C5alkyl. In some embodiments, the alkyl moiety of R18is C2-C4alkyl. In some embodiments, the alkyl moiety of R18is C2-C3alkyl. In some embodiments, the alkyl moiety of R18is Cs-Cealkyl. In some embodiments, the alkyl moiety of R18is C3-Csalkyl. In some embodiments, the alkyl moiety of R18is C3-C4alkyl. In some embodiments, the alkyl moiety of R18is C4-Cealkyl. In some embodiments, the alkyl moiety of R18is C4-C5alkyl. In some embodiments, the alkyl moiety of R18is Cs-Cealkyl.

[0238] In some embodiments, the alkyl moiety of R18is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R18are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R18are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R18is unsubstituted C-i- C6alkyl. In some embodiments, the alkyl moiety of R18is substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R18is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0239] In some embodiments, R18is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R18is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF31CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3ICH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3JCH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)31CH2CH2C(CF3)3Iand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R18is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R18isselected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, CDF2, CD3CHF2, CF3|CH2CH3, CH(CH3)2ICH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R18is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0240] In some embodiments, R18includes at least one deuterium atom. In some embodiments, R18includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R18are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R18are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R18are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R18are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R18are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R18are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R18are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R18are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R1Bare replaced with a halogen atom. In some embodiments, none of the available atoms of R18are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R18are replaced with a halogen atom and none of the available atoms of R18are replaced with an alternative isotope thereof.

[0241] In some embodiments, R19is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R19is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R19is halo. In some embodiments, R19is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R19is a halogen selected from fluorine and bromine. In some embodiments, R19is a halogen selected from fluorine and chlorine. In some embodiments, R19is a halogen selected from chlorine and bromine. In some embodiments, R19is fluorine. In some embodiments, R19is chlorine. In some embodiments, R19is bromine. In some embodiments, R19is iodine. In some embodiments, R19is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R19is D. In some embodiments R18and R19are the same as one another. In some embodiments, R18and R19are different from one another.

[0242] In some embodiments, R19includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R19is Ci-Cealkyl. In some embodiments, the alkyl moiety of R19is Ci-C5alkyl. In some embodiments, the alkyl moiety of R19is Ci-C4alkyl. In some embodiments, the alkyl moiety of R19is Ci-Caalkyl. In some embodiments, the alkyl moiety of R19is Ci-C2alkyl. In some embodiments, the alkyl moiety of R19is C2-C6alkyl. In some embodiments, the alkyl moiety of R19is C2-Csalkyl. In some embodiments, the alkyl moiety of R19is C2-C4alkyl. In some embodiments, the alkyl moiety of R19is C2-C3alkyl. In some embodiments, the alkyl moiety of R19is Cs-CealkyL In some embodiments, the alkyl moiety of R19is Cs-Csalkyl. In some embodiments, the alkyl moiety of R19is C3-C4alkyl. In some embodiments, the alkyl moiety of R19is C4-C6alkyl. In some embodiments, the alkyl moiety of R19is C4-Csalkyl. In some embodiments, the alkyl moiety of R19is Cs-Cgalkyl.

[0243] In some embodiments, the alkyl moiety of R19is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R19are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R19are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R19is unsubstituted Ci- CealkyL In some embodiments, the alkyl moiety of R19is substituted Ci-Csalkyl. In some embodiments, the alkyl moiety of R19is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0244] In some embodiments, R19is optionally substituted Ci-Cealkyl. In some embodiments, R19is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0245] In some embodiments, R19is selected from CH3]CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3IC(CFH2)3, C(CD3)3IC(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3]CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3ICH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R19is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R19is selected from CH3, CH2D, CHD2ICD3ICH2F, CHF2, CF3, CHDF, CD2F, CDF2ICD3CHF2, CF3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R19is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0246] In some embodiments, R19includes at least one deuterium atom. In some embodiments, R19includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R19are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R19are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R19are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R19are optionally and independently replaced with one or morerespective fluorine atoms and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R19are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R19are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R19are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R19are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R19are replaced with a halogen atom. In some embodiments, none of the available atoms of R19are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R19are replaced with a halogen atom and none of the available atoms of R19are replaced with an alternative isotope thereof.

[0247] In some embodiments,together form a carbonyl group having a structureover a bond means that the bond is attached to a remaining portion of the compound.

[0248] In some embodiments, R20is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R20is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R20is halo. In some embodiments, R20is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R20is a halogen selected from fluorine and bromine. In some embodiments, R20is a halogen selected from fluorine and chlorine. In some embodiments, R20is a halogen selected from chlorine and bromine. In some embodiments, R20is fluorine. In some embodiments, R20is chlorine. In some embodiments, R20is bromine. In some embodiments, R20is iodine. In some embodiments, R20is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R20is D.

[0249] In some embodiments, R20includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R20is Ci-Cealkyl. In some embodiments, the alkyl moiety of R20is CrCsalkyl. In some embodiments, the alkyl moiety of R20is CrC4alkyl. In some embodiments, the alkyl moiety of R20is C-i-Caalkyl. In some embodiments, the alkyl moiety of R20is Ci-C2alkyl. In some embodiments, the alkyl moiety of R20is C2-Cealkyl. In some embodiments, the alkyl moiety of R20is C2-C5alkyl. In some embodiments, the alkyl moiety of R20is C2-C4alkyl. In some embodiments, the alkyl moiety of R20is C2-C3alkyl. In some embodiments, the alkyl moiety of R20is Cs-Cealkyl. In some embodiments, the alkyl moiety of R20is Cs-Csalkyl. In some embodiments, the alkyl moiety of R20is C3-C4alkyl. In some embodiments, the alkyl moiety of R20is C4-Cealkyl. In some embodiments, the alkyl moiety of R20is C4-C5alkyl. In some embodiments, the alkyl moiety of R20is Cs-Cealkyl.

[0250] In some embodiments, the alkyl moiety of R20is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R20are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R20are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R20is unsubstituted Ci- C6alkyl. In some embodiments, the alkyl moiety of R20is substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R20is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0251] In some embodiments, R20is optionally substituted Ci-Cgalkyl. In some embodiments, R20is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0252] In some embodiments, R20is selected from CHs, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD31CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CHzCHzCDHz, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH31CH2CH2CH2CF3, CH2CH2CH2CD31CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, andCH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R20is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2, CH(CF3)2JCD(CD3)2JCF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R20is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, CDF2, CD3CHF2, CF3, CH2CH3, CH(CH3)2, CH(CD3)2Iand C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R20is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0253] In some embodiments, R20includes at least one deuterium atom. In some embodiments, R20includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R20are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of Rzoare optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Rzoare optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R20are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R20are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R20are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R20are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R20are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R20are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R20are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydragen atoms of R20are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R20are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R20are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R20are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R20are replacedwith a halogen atom. In some embodiments, none of the available atoms of R20are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R20are replaced with a halogen atom and none of the available atoms of R20are replaced with an alternative isotope thereof.

[0254] In some embodiments, R21is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R21is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R21is halo. In some embodiments, R21is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R21is a halogen selected from fluorine and bromine. In some embodiments, R21is a halogen selected from fluorine and chlorine. In some embodiments, R21is a halogen selected from chlorine and bromine. In some embodiments, R21is fluorine. In some embodiments, R21is chlorine. In some embodiments, RZ1is bromine. In some embodiments, R21is iodine. In some embodiments, RZ1is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, RZ1is D. In some embodiments RZDand RZ1are the same as one another. In some embodiments, R20and R21are different from one another.

[0255] In some embodiments, R21includes an alkyl moiety (e.g., optionally substituted Ci- C6alkyl). In some embodiments, the alkyl moiety of R21is Ci-C6alkyl. In some embodiments, the alkyl moiety of R21is Ci-C5alkyl. In some embodiments, the alkyl moiety of R21is Ci-C4alkyl. In some embodiments, the alkyl moiety of R21is Ci-Csalkyl. In some embodiments, the alkyl moiety of R21is Ci-Caalkyl. In some embodiments, the alkyl moiety of R21is C2-Cealkyl. In some embodiments, the alkyl moiety of R21is Ca-Csalkyl. In some embodiments, the alkyl moiety of R21is C2-C4alkyl. In some embodiments, the alkyl moiety of R21is C2-C3alkyl. In some embodiments, the alkyl moiety of R21is Cs-Csalkyl. In some embodiments, the alkyl moiety of R21is Cs-Csalkyl. In some embodiments, the alkyl moiety of R21is C3-C4alkyl. In some embodiments, the alkyl moiety of R21is C4-C6alkyl. In some embodiments, the alkyl moiety of R21is C4-Csalkyl. In some embodiments, the alkyl moiety of R21is Cs-Cealkyl.

[0256] In some embodiments, the alkyl moiety of R21is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R21are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R21are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R21is unsubstituted Ci- Cealkyl. In some embodiments, the alkyl moiety of R21is substituted C Cealkyl. In someembodiments, the alkyl moiety of R21is substituted with one or more substituents independently selected from OH and Ci-CsalkyleneOH (e g., CH2OH), including any member, combination, or subset thereof.

[0257] In some embodiments, R21is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof. In some embodiments, R21is selected from CH3, CD2H, CDH2ICD3ICF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3ICH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2ICH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3JC(CFH2)3, C(CD3)3, C(CHD2)31C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3JCH2CH(CH3)2, CH2CH(CD3)21CH2CH(CF3)2JCH(CH3)CH2CH3ICH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3ICH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3ICH2CH2C(CH3)31CH2CH2C(CF3)3Jand CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R21is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF21CF31CH2CH31CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)21CF(CF3)2, C(CH3)31C(CD3)3Iand C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R21is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, CDFZ, CD3CHF2, CF31CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R21is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0258] In some embodiments, R21includes at least one deuterium atom. In some embodiments, R21includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R21are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R21are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R21are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one ormore available hydrogen atoms of R21are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R21are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R21are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R21are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R21are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of RZ1are replaced with a halogen atom. In some embodiments, none of the available atoms of R21are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R21are replaced with a halogen atom and none of the available atoms of RZ1are replaced with an alternative isotope thereof.

[0259] In some embodiments, R18and R19are H, and R20and R21are D. In some embodiments, R18and R19are D, and R20and R21are H. In some embodiments, R18, R19, R20, and R21are each H. In some embodiments, R18, R19, R20, and R21are each D.

[0260] In some embodiments,together form a carbonyl group having a structurebond means that the bond is attached to a remaining portion of the compound. In some embodiments, R1Band R19together form a first carbonyl group and R20and R21together form a second carbonyl group in the same compound.

[0261] In some embodiments, R22is selected from halogen, optionally substituted Ci-Csalkyl, OH, optionally substituted OCi-Cealkyl, SH, and optionally substituted SCi-Cealkyl, including any member, combination, or subset thereof.

[0262] In some embodiments, R22includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl, optionally substituted OCi-Cealkyl, and optionally substituted SCi-Cealkyl). In some embodiments, each alkyl moiety of R22is independently Ci-Cealkyl. In some embodiments, each alkyl moiety of R22is independently Ci-C$alkyl. In some embodiments, each alkyl moiety of R22is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R22is independently C-i- Caalkyl. In some embodiments, each alkyl moiety of R22is independently C-i-Czalkyl. In some embodiments, each alkyl moiety of R22is independently Cz-Cealkyl. In some embodiments, each alkyl moiety of R22is independently Cz-Csalkyl. In some embodiments, each alkyl moiety of R22is independently Cj-C^alkyl. In some embodiments, each alkyl moiety of R22is independently C2- CaalkyL In some embodiments, each alkyl moiety of R22is independently Ca-Cealkyl. In some embodiments, each alkyl moiety of R22is independently Ca-Csalkyl. In some embodiments, each alkyl moiety of R22is independently C3-C4alkyl. In some embodiments, each alkyl moiety of R22is independently C -Cealkyl. In some embodiments, each alkyl moiety of R22is independently C4- Csalkyl. In some embodiments, each alkyl moiety of R22is independently Cs-Cealkyl.

[0263] In some embodiments, the alkyl moiety of R22(e.g., optionally substituted Ci-C6alkyl, optionally substituted OCi-C6alkyl, and optionally substituted SCi-C6alkyl) is independently selected from Ci-C6alkyl, CrC6deuteroalkyl, Ci-C6haloalkyl, and Ci-C6deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R22are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R22are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R22is independently unsubstituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R22is independently substituted Ci-Cealkyl. In some embodiments, the alkyl moiety of R22is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof. In some embodiments, the alkyl moiety of R22has one or more hydrogen atoms independently replaced by one or more respective halogen atoms and / or one or more atoms replaced by one or more respective alternative isotopes thereof.

[0264] In some embodiments, R22is halogen, i.e., is selected from F, Cl, Br, and I, including any member, combination, or subset thereof). In some embodiments, R22is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R22is a halogen selected from fluorine and bromine. In some embodiments, R22is a halogen selected from fluorine and chlorine. In some embodiments, R22is a halogen selected from chlorine and bromine. In someembodiments, R22is fluorine. In some embodiments, R22is chlorine. In some embodiments, R22is bromine. In some embodiments, R22is iodine. In some embodiments, R22is not halogen.

[0265] In some embodiments, R22is optionally substituted Ci-Cealkyl. In some embodiments, R22is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0266] In some embodiments, R22is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3IC(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH31CH2CH2CH2CF3, CH2CH2CH2CD3]CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CHZCH(CH3)CF31CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3ICH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R22is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0267] In some embodiments, R2Zis selected from OH and optionally substituted OCi-Cealkyl. In some embodiments, R22is selected from OH, OD, optionally substituted OCi-Cealkyl., including any member, combination, or subset thereof. In some embodiments, R22is selected from OH, OD, OCH3, OCH2D, OCHD2, OCD3, OCH2F, OCHF2, OCF3, OCH2CH3, OCD2CD3, OCF2CF3, OCH(CH3)2, OCH(CD3)2, OCH(CF3)2, OCD(CD3)2, OCF(CF3)2, OC(CH3)3, OC(CD3)3, and OC(CF3)3, including any member, combination, or subset thereof. In some embodiments, R22is selected from OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, and OCD3, including any member, combination, or subset thereof. In some embodiments, R22is selected from OH, OCH31OCHF2, and OCF3.

[0268] In some embodiments, R17is selected from SH and optionally substituted SCi-CealkyL In some embodiments, R17is selected from SH, SD, optionally substituted SCi-C6alkyl, including any member, combination, or subset thereof. In some embodiments, R22is selected from SH, SCH2F, SCHF2, SCF3, SD, SCH2D, SCHD2, and SCD3, including any member, combination, or subset thereof.

[0269] In some embodiments, R22is selected from F, optionally substituted Ci-C3alkyl, OH, optionally substituted OCi-C3alkyl, SH, and optionally substituted SCi-C3alkyl, including anymember, combination, or subset thereof. In some embodiments, R22is selected from OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, OCD3, SH, SCH2F, SCHF2, SCF3, SD, SCH2D, SCHD2, and SCD3, wherein none of the available hydrogen atoms of R22are replaced with respective halogen atoms and none of the available atoms of R22are replaced with respective alternative isotopes thereof.

[0270] In some embodiments, R22includes at least one deuterium atom. In some embodiments, R22includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R22are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and I) and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R22are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of Rzzare optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R22are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R22are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R22are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R22are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R22are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R22are replaced with a halogen atom. In some embodiments, none of the available atoms of R22are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms ofR22are replaced with a halogen atom and none of the available atoms of R22are replaced with an alternative isotope thereof.

[0271] In some embodiments, m is selected from 0 and 1. In some embodiments, m is 0. In some embodiments, m is 1.

[0272] In some embodiments Q is selected as Q3, wherein R2, R3, R4, R7, R18, R19, R20, and R21are H, to provide a compound having the structure of Formula (l-C-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from OH, OCH3, OC(O)(CH2)7CHCH=CH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, and SCH3;R22is selected from OH, OCH3, OCHF2, and OCF3; m is 0 or 1 ; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

[0273] In some embodiments Q is selected as Q4 to provide a compound having the structure of Formula (l-D-i):(l-D-i), wherein Xa, Xb, R1, R2, R3, R4, R5, R6, R7, R23, R24, R25, R26, and n are as defined (and provisos and exclusions provided for) herein.

[0274] In some embodiments, when Q is selected as Q4, a compound is provided having the structure of Formula (I), Formula (l-D-i), or Formula (l-D-ii), wherein none of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, R25, and R26are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, R7, R25, and R26are replaced with respective alternative isotopes thereof.

[0275] In some embodiments, the compound has the structure of Formula (I) or Formula (l-D- i), and R23is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, including any member, combination, or subset thereof. In some embodiments, R23is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R23is halo. In some embodiments, R23is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R23is a halogen selected from fluorine and bromine. In some embodiments, R23is a halogen selected from fluorine and chlorine. In some embodiments, R23is a halogen selected from chlorine and bromine. In some embodiments, R23is fluorine. In some embodiments, R23is chlorine. In some embodiments, R23is bromine. In some embodiments, R23is iodine. In some embodiments, R23is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R23is D.

[0276] In some embodiments, R23includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R23is Ci-Cgalkyl. In some embodiments, thealkyl moiety of R23is Ci-CsalkyL In some embodiments, the alkyl moiety of R23is Ci-C4alkyl. In some embodiments, the alkyl moiety of R23is Ci-Caalkyl. In some embodiments, the alkyl moiety of R23is Ci-C2alkyl. In some embodiments, the alkyl moiety of R23is C2-Cealkyl. In some embodiments, the alkyl moiety of R23is C2-C5alkyl. In some embodiments, the alkyl moiety of R23is C2-C4alkyl. In some embodiments, the alkyl moiety of R23is C2-C3alkyl. In some embodiments, the alkyl moiety of R23is Ca-CealkyL In some embodiments, the alkyl moiety of R23is Cs-Csalkyl. In some embodiments, the alkyl moiety of R23is C3-C alkyl. In some embodiments, the alkyl moiety of R23is C4-C6alkyl. In some embodiments, the alkyl moiety of R23is C4-Csalkyl. In some embodiments, the alkyl moiety of R23is Cs-Cealkyl.

[0277] In some embodiments, the alkyl moiety of R23is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R23are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R23are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R23is unsubstituted Ci- C6alkyl. In some embodiments, the alkyl moiety of R23is substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R23is substituted with one or more substituents independently selected from OH and Ci-C6alkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0278] In some embodiments, R23is optionally substituted Ci-C6alkyl. In some embodiments, R23is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0279] In some embodiments, R23is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3ICH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH31CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R23is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF31CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R23is selected from CH3,CHF2, CF3ICD3, CH2CH3ICH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R23is selected from H, D, F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0280] In some embodiments, R23includes at least one deuterium atom. In some embodiments, R23includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R23are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R23are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R23are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R23are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R23are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R23are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R23are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R23are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R23are replaced with a halogen atom. In some embodiments, none of the available atoms of R23are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R23are replaced with a halogen atom and none of the available atoms of R23are replaced with an alternative isotope thereof.

[0281] In some embodiments, R24is selected from H, D, halogen, and optionally substituted Ci- Cealkyl, including any member, combination, or subset thereof. In some embodiments, R24is selected from H, D, and halo, including any member, combination, or subset thereof (e.g., H, D, and halo; H and D; H and halo; D and halo; H alone; D alone; halo alone). In some embodiments, R24is halo. In some embodiments, R24is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R24is a halogen selected from fluorine and bromine. In some embodiments, R24is a halogen selected from fluorine and chlorine. In some embodiments, R24is a halogen selected from chlorine and bromine. In some embodiments, R24is fluorine. In some embodiments, R24is chlorine. In some embodiments, R24is bromine. In some embodiments, R24is iodine. In some embodiments, R24is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R24is D. In some embodiments R23and R24are the same as one another. In some embodiments, R23and R24are different from one another.

[0282] In some embodiments, R24includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl). In some embodiments, the alkyl moiety of R24is Ci-Cealkyl. In some embodiments, the alkyl moiety of R24is Ci-C5alkyl. In some embodiments, the alkyl moiety of R24is Ci-C4alkyl. In some embodiments, the alkyl moiety of R24is Ci-Caalkyl. In some embodiments, the alkyl moiety of R24is Ci-C2alkyl. In some embodiments, the alkyl moiety of R24is C2-C6alkyl. In some embodiments, the alkyl moiety of R24is C2-Csalkyl. In some embodiments, the alkyl moiety of R24is C2-C4alkyl. In some embodiments, the alkyl moiety of R24is C2-C3alkyl. In some embodiments, the alkyl moiety of R24is Cs-Cealkyl. In some embodiments, the alkyl moiety of R24is Ca-Csalkyl. In some embodiments, the alkyl moiety of R24is C3-C4alkyl. In some embodiments, the alkyl moiety of R24is C4-Cealkyl. In some embodiments, the alkyl moiety of R24is C4-C5alkyl. In some embodiments, the alkyl moiety of R24is Cs-Cgalkyl.

[0283] In some embodiments, the alkyl moiety of R24is selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R24are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R24are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R24is unsubstituted Ci- CealkyL In some embodiments, the alkyl moiety of R24is substituted Ci-Csalkyl. In some embodiments, the alkyl moiety of R24is substituted with one or more substituents independently selected from OH and Ci-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0284] In some embodiments, R24is optionally substituted Ci-Cealkyl. In some embodiments, R24is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0285] In some embodiments, R24is selected from CH3]CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3, C(CF3)3, C(CHF2)3IC(CFH2)3, C(CD3)3IC(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3]CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3ICH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R24is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R24is selected from CH3, CHF2, CF3JCD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R24is selected from H, D, F, CH3, CH2D, CHD2, CD3JCH2F, CHF2JCF3ICHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0286] In some embodiments, R24includes at least one deuterium atom. In some embodiments, R24includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R24are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R24are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R24are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R24are optionally and independently replaced with one or morerespective fluorine atoms and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R24are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R24are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen of R24are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R24are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R24are replaced with a halogen atom. In some embodiments, none of the available atoms of R24are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R24are replaced with a halogen atom and none of the available atoms of R24are replaced with an alternative isotope thereof.

[0287] In some embodiments, R23and R24are H. In some embodiments, R23and R24are D. In some embodiments, R23is H and R24is D.

[0288] In some embodiments, R23and R24(i.e. ,) together form a carbonyl group having a structureover a bond means that the bond is attached to a remaining portion of the compound.

[0289] In some embodiments, R25is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted Ci-CealkyleneOCi-Cgalkyl, including any member, combination, or subset thereof, wherein R25is not selected from F, Cl, Br, and I, that is, R25does not solely consist of halo. In some embodiments, R25is selected from H not replaced with a halogen atom, Ci-C3alkyl, and CH2CH2OCH3, including any member, combination, or subset thereof. In some embodiments, R25is selected from H not replaced with a halogen atom and D, including any member,combination, or subset thereof. In some embodiments, R25is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R25is D.

[0290] In some embodiments, R25includes an alkyl moiety (e.g., optionally substituted Ci- Cealkyl and optionally substituted Ci-CsalkyleneOCi-Cealkyl). In some embodiments, the alkyl moiety of R25is independently Ci-Cealkyl. In some embodiments, the alkyl moiety of R25is independently Ci-Csalkyl. In some embodiments, the alkyl moiety of R25is independently C-i- C4alkyl. In some embodiments, the alkyl moiety of R25is independently C-i-Csalkyl. In some embodiments, the alkyl moiety of R25is independently Ci-C?alkyl. In some embodiments, the alkyl moiety of R25is independently Cz-Cealkyl. In some embodiments, the alkyl moiety of R25is independently C2-C5alkyl. In some embodiments, the alkyl moiety of R25is independently C2- C4alkyl. In some embodiments, the alkyl moiety of R25is independently C2-C3alkyl. In some embodiments, the alkyl moiety of R25is independently Cs-Cealkyl. In some embodiments, the alkyl moiety of R25is independently Cs-Csalkyl. In some embodiments, the alkyl moiety of R25is independently C3-C4alkyl. In some embodiments, the alkyl moiety of R25is independently C4- C6alkyl. In some embodiments, the alkyl moiety of R25is independently C4-C5alkyl. In some embodiments, the alkyl moiety of R25is independently Cs-Cgalkyl.

[0291] In some embodiments, the alkyl moiety of R25is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R25are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R25are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R25is independently unsubstituted Ci-CBalkyl. In some embodiments, the alkyl moiety of R25is independently substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R25is substituted with one or more substituents independently selected from OH and Ci-CBalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0292] In some embodiments, the alkylene moiety of R25(e.g., optionally substituted C1- C6alkyleneOCi-C6alkyl) is Ci-C6alkylene. In some embodiments, the alkylene moiety of R25is C1- Csalkylene. In some embodiments, the alkylene moiety of R25is Ci-C4alkylene. In some embodiments, the alkylene moiety of R25is Ci-Csalkylene. In some embodiments, the alkylene moiety of R25is Ci-C2alkylene. In some embodiments, the alkylene moiety of R25is C2-C6alkylene. In some embodiments, the alkylene moiety of R25is C2-C5alkylene. In some embodiments, the alkylene moiety of R25is C2-C4alkylene. In some embodiments, the alkylene moiety of R25is C2- C3alkylene. In some embodiments, the alkylene moiety of R25is C3-C6alkylene. In someembodiments, the alkylene moiety of R25is C3-Csalkylene. In some embodiments, the alkylene moiety of R25is C3-C4alkylene. In some embodiments, the alkylene moiety of R25is C^Cgalkylene. In some embodiments, the alkylene moiety of R25is C4-C5alkylene. In some embodiments, the alkylene moiety of R25is Cs-Cealkylene.

[0293] In some embodiments, the alkylene moiety of R25is selected from alkylene, deuteroalkylene, haloalkylene, and deuterohaloalkylene, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkylene moiety of R25are replaced by a halogen atom and none of the available atoms of the alkylene moiety of R25are replaced by an alternative isotope thereof. In some embodiments, the alkylene moiety of R25is unsubstituted Ci-Cealkylene. In some embodiments, the alkylene moiety of R25is substituted C-i-Cgalkylene. In some embodiments, the alkylene moiety of R25is substituted with one or more substituents independently selected from OH and C-i-CgalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0294] In some embodiments, R25is optionally substituted C-i-Cealkyl. In some embodiments, R25is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0295] In some embodiments, R25is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2IC(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF3ICH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R25is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2, CH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R25is selected from CH3, CHF2, CF3, CD3ICH2CH3ICH(CH3)2, CH(CD3)2Iand C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R25is selected from H, D, CH3, CHF2, CF3, CD3, CH2CH3, CH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R25is selected from H, D, CH3, CD3, CH2CH3, and CH(CH3)2,including any member, combination, or subset thereof. In some embodiments, R25is CH2CH2OCH. In some embodiments, R25is selected from H, CH3, and CH2CH2OCH3.

[0296] In some embodiments, R25includes at least one deuterium atom. In some embodiments, optionally substituted C-i-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R25includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of C-i-Cealkyl and C-i-CealkyleneOC-i-Csalkyl of R25are optionally and independently replaced with one or more respective halogen atoms (i e. , F, Cl, Br, and / or I) and / or one or more available atoms of R25are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R25are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R25are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted Ci-C6alkyleneOCi-C6alkyl of R25are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R25are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-CBalkyl and optionally substituted CrCealkyleneOCi-Cgalkyl of R25are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R25are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted C-i-CgalkyleneOCi-Cealkyl of R25are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R25are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted Ci-C6alkyleneOCi-CBalkyl of R25are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R25are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Csalkyl and optionally substituted Ci-CsalkyleneOCi-Cgalkyl of R25are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R25are optionally and independently replaced with one or more respectivealternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted Ci-CealkyleneOCi-Csalkyl of R25are replaced with a halogen atom. In some embodiments, none of the available atoms of R25are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of optionally substituted Ci-Cealkyl and optionally substituted Ci-CealkyleneOCi- Cealkyl of R25are replaced with a halogen atom and none of the available atoms of R25are replaced with an alternative isotope thereof.

[0297] In some embodiments, R26is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OCi-Cealkyl, SH, and optionally substituted SCi-Cealkyl, including any member, combination, or subset thereof.

[0298] In some embodiments, R26includes an alkyl moiety (e.g., optionally substituted Ci- C6alkyl, optionally substituted OCi-C6alkyl, and optionally substituted SCi-C6alkyl). In some embodiments, each alkyl moiety of R26is independently Ci-CBalkyl. In some embodiments, each alkyl moiety of R26is independently Ci-Csalkyl. In some embodiments, each alkyl moiety of R26is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R26is independently Ci- Caalkyl. In some embodiments, each alkyl moiety of R26is independently Ci-C2alkyl. In some embodiments, each alkyl moiety of R26is independently C2-C6alkyl. In some embodiments, each alkyl moiety of R26is independently C2-C5alkyl. In some embodiments, each alkyl moiety of R26is independently C2-C4alkyl. In some embodiments, each alkyl moiety of R26is independently C2- Caalkyl. In some embodiments, each alkyl moiety of R26is independently Ca-Csalkyl. In some embodiments, each alkyl moiety of R2Bis independently Ca-Csalkyl. In some embodiments, each alkyl moiety of R26is independently C3-C4alkyl. In some embodiments, each alkyl moiety of R26is independently C4-C6alkyl. In some embodiments, each alkyl moiety of R26is independently C4- C5alkyl. In some embodiments, each alkyl moiety of R26is independently C5-C6alkyl.

[0299] In some embodiments, the alkyl moiety of R26(e.g., optionally substituted Ci-C6alkyl, optionally substituted OCi-C6alkyl, and optionally substituted SCi-C6alkyl) is independently selected from Ci-C6alkyl, CrC6deuteroalkyl, Ci-C6haloalkyl, and Ci-C6deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R26are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R26are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R26is independently unsubstituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R26is independently substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R2Sis substituted with one or more substituents independentlyselected from OH and C-i-CsalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0300] In some embodiments, R26is halogen, i.e., is selected from F, Cl, Br, and I, including any member, combination, or subset thereof). In some embodiments, R26is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R26is a halogen selected from fluorine and bromine. In some embodiments, R26is a halogen selected from fluorine and chlorine. In some embodiments, R26is a halogen selected from chlorine and bromine. In some embodiments, R26is fluorine. In some embodiments, R26is chlorine. In some embodiments, R26is bromine. In some embodiments, R26is iodine. In some embodiments, R26is not halogen.

[0301] In some embodiments, R26is optionally substituted Ci-Cealkyl. In some embodiments, R26is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0302] In some embodiments, R26is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3JC(CF3)3IC(CHF2)3IC(CFH2)3, C(CD3)3, C(CHD2)3IC(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3ICH2CH(CH3)CF3, CH2CH(CH3)CD3ICH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)31CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R26is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0303] In some embodiments, R26is selected from OH and optionally substituted OCi-Cealkyl. In some embodiments, R26is selected from OH, OD, optionally substituted OCi-Cealkyl, including any member, combination, or subset thereof. . In some embodiments, R2Bis selected from OH, OD, OCH3, OCH2D, OCHD2IOCD3, OCH2F, OCHF2, OCF3, OCH2CH3IOCD2CD3, OCF2CF3, OCH(CH3)2, OCH(CD3)2, OCH(CF3)2, OCD(CD3)2, OCF(CF3)2, OC(CH3)3, OC(CD3)3, and OC(CF3)3, including any member, combination, or subset thereof. In some embodiments, R26is selected from OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, and OCD3, including any member, combination, or subset thereof. In some embodiments, R26is selected from OH, OCH3, OCHF2, and OCF3.

[0304] In some embodiments, R2Bis selected from SH and optionally substituted SCi-CealkyL In some embodiments, R26is selected from SH, SD, optionally substituted SCi-Cealkyl, or subset thereof.. In some embodiments, R26is selected from SH, SD, SCH2F, SCHF2, SCF3, SCH2D, SCHD2, and SCD3, including any member, combination, or subset thereof.

[0305] In some embodiments, R26is selected from F, optionally substituted Ci-Csalkyl, OH, optionally substituted OC-i-Csalkyl, SH, and optionally substituted SCi-Csalkyl, including any member, combination, or subset thereof. In some embodiments, R26is selected from F, CH3, CH2D, CHD2ICD3ICH2F, CHF2, CF3, CHDF, CD2F, CDF2, OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, OCD3, SH, SCH2F, SCHF2, SCF3, SD, SCH2D, SCHD2, and SCD3, wherein none of the available hydrogen atoms of R26are replaced with respective halogen atoms and none of the available atoms of R26are replaced with respective alternative isotopes thereof.

[0306] In some embodiments, R26includes at least one deuterium atom. In some embodiments, R26includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R26are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2Bare optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R26are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R26are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R2Bare optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R26are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternativeisotopes thereof. In some embodiments, one or more available hydrogen of R26are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R26are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R26are replaced with a halogen atom. In some embodiments, none of the available atoms of R26are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of R26are replaced with a halogen atom and none of the available atoms of R26are replaced with an alternative isotope thereof.

[0307] In some embodiments, n is selected from 0 and 1 . In some embodiments, n is 0. In some embodiments, n is 1 .

[0308] In some embodiments Q is selected as Q4, wherein R2, R3, R4, R7, R23, and R24are H, and n is 0, to provide a compound having the structure of Formula (l-D-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from OH, OCH3, OCHF2, OP(O)(OH)2, andR25is selected from H and CH3; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

[0309] In some embodiments Q is selected as Q5 to provide a compound having the structure of Formula (l-E-i):wherein Xa, Xb, R1, R2, R3, R4, R5, R6, R7, R27, R28, and p are as defined (and provisos and exclusions provided for) herein.

[0310] In some embodiments, when Q is selected as Q5, a compound is provided having the structure of Formula (l-E-i), wherein none of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, R27, and R28are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, R7, R27, and R28are replaced with respective alternative isotopes thereof.

[0311] In some embodiments, R27is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC-i-Cealkyl, SH, and optionally substituted SCi-Cealkyl, including any member, combination, or subset thereof.

[0312] In some embodiments, R27includes an alkyl moiety (e.g., optionally substituted Ci- Csalkyl, optionally substituted OCi-Cealkyl, and optionally substituted SC-i-Cealkyl). In some embodiments, each alkyl moiety of R27is independently Ci-Cealkyl. In some embodiments, each alkyl moiety of R27is independently Ci-Csalkyl. In some embodiments, each alkyl moiety of R27is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R27is independently Ci- Caalkyl. In some embodiments, each alkyl moiety of R27is independently Ci-Czalkyl. In some embodiments, each alkyl moiety of R27is independently Cz-Cealkyl. In some embodiments, each alkyl moiety of R27is independently C2-Csalkyl. In some embodiments, each alkyl moiety of R27is independently C2-C4alkyl. In some embodiments, each alkyl moiety of R27is independently C2- CsalkyL In some embodiments, each alkyl moiety of R27is independently Ca-Cealkyl. In some embodiments, each alkyl moiety of R27is independently Cs-Csalkyl. In some embodiments, each alkyl moiety of R27is independently C3-C4alkyl. In some embodiments, each alkyl moiety of R27is independently C4-C6alkyl. In some embodiments, each alkyl moiety of R27is independently C4- C5alkyl. In some embodiments, each alkyl moiety of R27is independently C5-C6alkyl.

[0313] In some embodiments, the alkyl moiety of R27(e.g., optionally substituted Ci-C6alkyl, optionally substituted OCi-C6alkyl, and optionally substituted SCi-C6alkyl) is independently selected from Ci-Cealkyl, C-i-Cedeuteroalkyl, Ci-Cehaloalkyl, and Ci-Cedeuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R27are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R27are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R27is independently unsubstituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R27is independently substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R27is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0314] In some embodiments, R27is halogen, i.e., selected from F, Cl, Br, and I, including any member, combination, or subset thereof). In some embodiments, R27is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R27is a halogen selected from fluorine and bromine. In some embodiments, R27is a halogen selected from fluorine and chlorine. In some embodiments, R27is a halogen selected from chlorine and bromine. In some embodiments, R27is fluorine. In some embodiments, R27is chlorine. In some embodiments, R27is bromine. In some embodiments, R27is iodine. In some embodiments, R27is not halogen.

[0315] In some embodiments, R27is optionally substituted Ci-Cealkyl. In some embodiments, R27is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0316] In some embodiments, R27is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF31CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3IC(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3, CH2CH2CH2CH31CH2CH2CH2CF3, CH2CH2CH2CD3]CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CHZCH(CH3)CF31CH2CH(CH3)CD3, CH2C(CH3)3, CH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3, CHZCH2C(CF3)3, and CHZCHZC(CD3)3, including any member, combination, or subset thereof. In some embodiments, R27is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0317] In some embodiments, R27is selected from OH and optionally substituted OCi-CealkyL In some embodiments, R27is selected from OH, OD, optionally substituted OCi-Cealkyl, including any member, combination, or subset thereof. In some embodiments, R27is selected from OH, OD, OCH3, OCH2D, OCHD2, OCD3, OCH2F, OCHF2, OCF3, OCH2CH3, OCD2CD3, OCF2CF3, OCH(CH3)2, OCH(CD3)2, OCH(CF3)2, OCD(CD3)2, OCF(CF3)2, OC(CH3)3, OC(CD3)3, and OC(CF3)3, including any member, combination, or subset thereof. In some embodiments, R27is selected from OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, and OCD3, including any member, combination, or subset thereof. In some embodiments, R27is selected from OH, OCH3, OCHF2, and OCF3.

[0318] In some embodiments, R27is selected from SH and optionally substituted SCi-CealkyL In some embodiments, R27is selected from SH, SD, optionally substituted SCi-C6alkyl, including any member, combination, or subset thereof. In some embodiments, R27is selected from SH, SD, SCH2F, SCHF2, SCF3, SCH2D, SCHD2, and SCD3, including any member, combination, or subset thereof.

[0319] In some embodiments, R27is selected from F, optionally substituted Ci-Csalkyl, OH, optionally substituted OCi-C3alkyl, SH, and optionally substituted SCi-C3alkyl, including anymember, combination, or subset thereof. In some embodiments, R27is selected from F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, CDF2, OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2JOCD3, SH, SCH2F, SCHF2, SCF3JSD, SCH2D, SCHD2Jand SCD3, wherein none of the available hydrogen atoms of R27are replaced with respective halogen atoms and none of the available atoms of R27are replaced with respective alternative isotopes thereof.

[0320] In some embodiments, R27includes at least one deuterium atom. In some embodiments, R27includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R27are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R27are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R27are replaced with a halogen atom. In some embodiments, none of the available atoms of R27are replaced with an alternative isotope thereof. In some embodiments, none of theavailable hydrogen atoms of R27are replaced with a halogen atom and none of the available atoms of R27are replaced with an alternative isotope thereof.

[0321] In some embodiments, p is selected from 0 and 1 . In some embodiments, p is 0. In some embodiments, p is 1 .

[0322] In some embodiments, R28is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted Ci-CealkyleneOCi-CBalkyl, including any member, combination, or subset thereof, wherein R28is not selected from F, Cl, Br, and I, that is, R28does not solely consist of halo. In some embodiments, R28is selected from H not replaced with a halogen atom, C-i-Caalkyl, and CH2CH2OCH3, including any member, combination, or subset thereof. In some embodiments, R28is selected from H not replaced with a halogen atom and D, including any member, combination, or subset thereof. In some embodiments, R28is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R28is D.

[0323] In some embodiments, R28includes an alkyl moiety (e.g., optionally substituted C1- CBalkyl and optionally substituted Ci-CBalkyleneOCi-CBalkyl). In some embodiments, the alkyl moiety of R28is independently Ci-CBalkyl. In some embodiments, the alkyl moiety of R28is independently Ci-CBalkyl. In some embodiments, the alkyl moiety of R28is independently C1- C4alkyl. In some embodiments, the alkyl moiety of R28is independently Ci-C3alkyl. In some embodiments, the alkyl moiety of R28is independently Ci-C2alkyl. In some embodiments, the alkyl moiety of R28is independently C2-CBalkyl. In some embodiments, the alkyl moiety of R28is independently C2-C5alkyl. In some embodiments, the alkyl moiety of R28is independently C2- C4alkyl. In some embodiments, the alkyl moiety of R28is independently C2-C3alkyl. In some embodiments, the alkyl moiety of R28is independently C3-CBalkyl. In some embodiments, the alkyl moiety of R28is independently C3-CBalkyl. In some embodiments, the alkyl moiety of R28is independently C3-C4alkyl. In some embodiments, the alkyl moiety of R28is independently C4- CBalkyl. In some embodiments, the alkyl moiety of R28is independently C4-C5alkyl. In some embodiments, the alkyl moiety of R28is independently CB-CBalkyl.

[0324] In some embodiments, the alkyl moiety of R28is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R28are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R28are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R28is independently unsubstituted Ci-CBalkyl. In some embodiments, the alkyl moiety of R28is independently substituted Ci-CBalkyl. In some embodiments, the alkyl moiety of R28is substitutedwith one or more substituents independently selected from OH and Ci-CsalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0325] In some embodiments, the alkylene moiety of R28(e.g., optionally substituted C1- CealkyleneOCi-Cealkyl) is C-i-Cealkylene. In some embodiments, the alkylene moiety of R28is C1- Csalkylene. In some embodiments, the alkylene moiety of R28is Ci-C4alkylene. In some embodiments, the alkylene moiety of R28is Ci-C3alkylene. In some embodiments, the alkylene moiety of R28is Ci-C2alkylene. In some embodiments, the alkylene moiety of R28is C2-C6alkylene. In some embodiments, the alkylene moiety of R28is C2-C5alkylene. In some embodiments, the alkylene moiety of R28is C2-C4alkylene. In some embodiments, the alkylene moiety of R28is C2- C3alkylene. In some embodiments, the alkylene moiety of R28is C3-Cealkylene. In some embodiments, the alkylene moiety of R28is Cs-Csalkylene. In some embodiments, the alkylene moiety of R28is C3-C4alkylene. In some embodiments, the alkylene moiety of R28is C4-Cealkylene. In some embodiments, the alkylene moiety of R28is C4-Csalkylene. In some embodiments, the alkylene moiety of R28is Cs-Cealkylene.

[0326] In some embodiments, the alkylene moiety of R28is selected from alkylene, deuteroalkylene, haloalkylene, and deuterohaloalkylene, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkylene moiety of R28are replaced by a halogen atom and none of the available atoms of the alkylene moiety of R28are replaced by an alternative isotope thereof. In some embodiments, the alkylene moiety of R28is unsubstituted Ci-Cgalkylene. In some embodiments, the alkylene moiety of R28is substituted Ci-Csalkylene. In some embodiments, the alkylene moiety of R28is substituted with one or more substituents independently selected from OH and Ci-CgalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0327] In some embodiments, R28is optionally substituted Ci-Cealkyl. In some embodiments, R28is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0328] In some embodiments, R28is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3]CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3ICH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2ICH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2IC(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3ICH2CH2CH2CH3ICH2CH2CH2CF3ICH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)21CH(CH3)CH2CH3ICH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF31CH2CH(CH3)CD3, CH2C(CH3)3ICH2C(CF3)3JCH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R28is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(CH3)3, C(CD3)3, and C(CF3)3, including any member, combination, or subset thereof. In some embodiments, R28is selected from CH3, CHF2, CF3ICD3, CH2CH3ICH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R28is selected from H, D, CH3, CHF2, CF3, CD3, CH2CH3JCH(CH3)2, CH(CD3)2, and C(CH3)3, including any member, combination, or subset thereof. In some embodiments, R28is selected from H, D, CH3, CD3, CH2CH3, and CH(CH3)2, including any member, combination, or subset thereof. In some embodiments, R28is CH2CH2OCH. In some embodiments, R28is selected from H, CH3, and CH2CH2OCH3.

[0329] In some embodiments, R28includes at least one deuterium atom. In some embodiments, optionally substituted C-i-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R28includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of Ci-C6alkyl and Ci-C6alkyleneOCi-C6alkyl of R28are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Cgalkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R28are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of RZBare optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted C-i-C6alkyleneOCi-C6alkyl of R28are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Cealkyl and optionally substituted Ci-CBalkyleneOCi-C6alkyl of R28are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R28are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of optionally substituted Ci-Csalkyl and optionally substituted Ci-CsalkyleneOCi-Csalkyl of R28are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R28are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of optionally substituted C-i-Cealkyl and optionally substituted Ci-CealkyleneOCi-Cealkyl of R28are replaced with a halogen atom. In some embodiments, none of the available atoms of R28are replaced with an alternative isotope thereof. In some embodiments, none of the available hydrogen atoms of optionally substituted Ci-C6alkyl and optionally substituted Ci-C6alkyleneOCi- Cgalkyl of R28are replaced with a halogen atom and none of the available atoms of R28are replaced with an alternative isotope thereof.

[0330] In some embodiments Q is selected as Q5, wherein R2, R3, R4, R5, R6, and R7are H, and p is 0, to provide a compound having the structure of Formula (l-E-ii):(l-E-ii), wherein:R1is selected from OCH3, OCHF2, andR28is selected from H, CH3, and CH2CH3; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

[0331] In some embodiments Q is selected as Q6 to provide a compound having the structure of Formula (l-F-i):wherein Xa, Xb, R1, R2, R3, R4, R5, R6, R7, R29, R30, and q are as defined (and provisos and exclusions provided for) herein.

[0332] In some embodiments, when Q is selected as Q6, a compound is provided having the structure of Formula (l-F-i), wherein none of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, R29, and R30are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, R7, R29, and R30are replaced with respective alternative isotopes thereof.

[0333] In some embodiments, R29is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC-i-Cealkyl, SH, and optionally substituted SCi-Cealkyl, including any member, combination, or subset thereof.

[0334] In some embodiments, R29includes an alkyl moiety (e.g., optionally substituted Ci- Csalkyl, optionally substituted OCi-Cealkyl, and optionally substituted SC-i-Cealkyl). In some embodiments, each alkyl moiety of R29is independently Ci-Cealkyl. In some embodiments, each alkyl moiety of R29is independently Ci-Csalkyl. In some embodiments, each alkyl moiety of R29is independently Ci-C4alkyl. In some embodiments, each alkyl moiety of R29is independently Ci- Caalkyl. In some embodiments, each alkyl moiety of R29is independently Ci-Czalkyl. In some embodiments, each alkyl moiety of R29is independently Cz-Cealkyl. In some embodiments, each alkyl moiety of R29is independently C2-Csalkyl. In some embodiments, each alkyl moiety of R29is independently C2-C4alkyl. In some embodiments, each alkyl moiety of R29is independently C2- CsalkyL In some embodiments, each alkyl moiety of R29is independently Ca-Cealkyl. In some embodiments, each alkyl moiety of R29is independently Cs-Csalkyl. In some embodiments, each alkyl moiety of R29is independently C3-C4alkyl. In some embodiments, each alkyl moiety of R29is independently C4-C6alkyl. In some embodiments, each alkyl moiety of R29is independently C4- C5alkyl. In some embodiments, each alkyl moiety of R29is independently C5-C6alkyl.

[0335] In some embodiments, the alkyl moiety of R29(e.g., optionally substituted Ci-C6alkyl, optionally substituted OCi-C6alkyl, and optionally substituted SCi-C6alkyl) is independently selected from Ci-Cealkyl, C-i-Cedeuteroalkyl, Ci-Cehaloalkyl, and Ci-Cedeuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R29are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R29are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R29is independently unsubstituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R29is independently substituted Ci-C6alkyl. In some embodiments, the alkyl moiety of R29is substituted with one or more substituents independently selected from OH and C-i-CealkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0336] In some embodiments, R29is halogen, i.e., is selected from F, Cl, Br, and I, including any member, combination, or subset thereof). In some embodiments, R29is a halogen selected from fluorine, chlorine, and bromine. In some embodiments, R29is a halogen selected from fluorine and bromine. In some embodiments, R29is a halogen selected from fluorine and chlorine. In some embodiments, R29is a halogen selected from chlorine and bromine. In someembodiments, R29is fluorine. In some embodiments, R29is chlorine. In some embodiments, R29is bromine. In some embodiments, R29is iodine. In some embodiments, R29is not halogen.

[0337] In some embodiments, R29is optionally substituted Ci-Cealkyl. In some embodiments, R29is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0338] In some embodiments, R29is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3, CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3, CH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2, CH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2, C(CH3)3IC(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3IC(CHD2)3, C(CDH2)3, CH2CH2CH2CH3, CH2CH2CH2CF3, CH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)2, CH(CH3)CH2CH3, CH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CHZCH(CH3)CF3, CH2CH(CH3)CD3, CH2C(CH3)3ICH2C(CF3)3, CH2C(CD3)3, CH2CH2C(CH3)3ICH2CH2C(CF3)31and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R29is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, and CDF2, including any member, combination, or subset thereof.

[0339] In some embodiments, R29is selected from OH and optionally substituted OCi-Cealkyl. In some embodiments, R29is selected from OH, OD, optionally substituted OCi-Cealkyl, including any member, combination, or subset thereof.. In some embodiments, R29is selected from OH, OD, OCH3, OCH2D, OCHD2, OCD3, OCH2F, OCHF2, OCF3, OCH2CH3, OCD2CD3, OCF2CF3, OCH(CH3)2JOCH(CD3)2, OCH(CF3)2, OCD(CD3)2, OCF(CF3)2, OC(CH3)3, OC(CD3)3, and OC(CF3)3, including any member, combination, or subset thereof. In some embodiments, R29is selected from OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2, and OCD3, including any member, combination, or subset thereof. In some embodiments, R29is selected from OH, OCH3, OCHF2, and OCF3.

[0340] In some embodiments, R29is selected from SH and optionally substituted SCi-CealkyL In some embodiments, R29is selected from SH, SD, optionally substituted SCi-C6alkyl, including any member, combination, or subset thereof.. In some embodiments, R29is selected from SH, SD, SCH2F, SCHF2ISCF3, SCH2D, SCHD2, and SCD3, including any member, combination, or subset thereof.

[0341] In some embodiments, R29is selected from F, optionally substituted Ci-C3alkyl, OH, optionally substituted OCi-C3alkyl, SH, and optionally substituted SCi-C3alkyl, including anymember, combination, or subset thereof. In some embodiments, R29is selected from F, CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CHDF, CD2F, CDF2, OH, OCH2F, OCHF2, OCF3, OD, OCH2D, OCHD2JOCD3, SH, SCH2F, SCHF2, SCF3JSD, SCH2D, SCHD2Jand SCD3, wherein none of the available hydrogen atoms of R29are replaced with respective halogen atoms and none of the available atoms of R29are replaced with respective alternative isotopes thereof.

[0342] In some embodiments, R29includes at least one deuterium atom. In some embodiments, R29includes at least one halogen atom. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective halogen atoms (i.e., F, Cl, Br, and / or I) and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective fluorine atoms, one or more respective chlorine atoms, and / or one or more respective bromine atoms, and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective fluorine atoms and / or one or more respective chlorine atoms, and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective chlorine atoms and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective bromine atoms and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, one or more available hydrogen atoms of R29are optionally and independently replaced with one or more respective iodine atoms and / or one or more available atoms of R29are optionally and independently replaced with one or more respective alternative isotopes thereof. In some embodiments, none of the available hydrogen atoms of R29are replaced with a halogen atom. In some embodiments, none of the available atoms of R29are replaced with an alternative isotope thereof. In some embodiments, none of theavailable hydrogen atoms of R29are replaced with a halogen atom and none of the available atoms of R29are replaced with an alternative isotope thereof.

[0343] In some embodiments, q is selected from 0 and 1 . In some embodiments, q is 0. In some embodiments, q is 1 .

[0344] In some embodiments, R30is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted Ci-CealkyleneOCi-CBalkyl, including any member, combination, or subset thereof, wherein R30is not selected from F, Cl, Br, and I, that is, R30does not solely consist of halo. In some embodiments, R30is selected from H not replaced with a halogen atom, C-i-Caalkyl, and CH2CH2OCH3, including any member, combination, or subset thereof. In some embodiments, R30is selected from H not replaced with a halogen atom and D, including any member, combination, or subset thereof. In some embodiments, R30is H not replaced with a halogen atom or an alternative isotope thereof. In some embodiments, R30is D.

[0345] In some embodiments, R30includes an alkyl moiety (e.g., optionally substituted C1- CBalkyl and optionally substituted Ci-CBalkyleneOCi-CBalkyl). In some embodiments, the alkyl moiety of R30is independently Ci-CBalkyl. In some embodiments, the alkyl moiety of R30is independently Ci-CBalkyl. In some embodiments, the alkyl moiety of R30is independently C1- C4alkyl. In some embodiments, the alkyl moiety of R30is independently Ci-C3alkyl. In some embodiments, the alkyl moiety of R30is independently Ci-C2alkyl. In some embodiments, the alkyl moiety of R30is independently C2-C6alkyl. In some embodiments, the alkyl moiety of R30is independently C2-C5alkyl. In some embodiments, the alkyl moiety of R30is independently C2- C4alkyl. In some embodiments, the alkyl moiety of R30is independently C2-C3alkyl. In some embodiments, the alkyl moiety of R30is independently C3-CBalkyl. In some embodiments, the alkyl moiety of R30is independently C3-CBalkyl. In some embodiments, the alkyl moiety of R30is independently C3-C4alkyl. In some embodiments, the alkyl moiety of R30is independently C4- CBalkyl. In some embodiments, the alkyl moiety of R30is independently C4-C5alkyl. In some embodiments, the alkyl moiety of R30is independently CB-CBalkyl.

[0346] In some embodiments, the alkyl moiety of R30is independently selected from alkyl, deuteroalkyl, haloalkyl, and deuterohaloalkyl, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkyl moiety of R30are replaced by a halogen atom and none of the available atoms of the alkyl moiety of R30are replaced by an alternative isotope thereof. In some embodiments, the alkyl moiety of R30is independently unsubstituted Ci-CBalkyl. In some embodiments, the alkyl moiety of R30is independently substituted Ci-CBalkyl. In some embodiments, the alkyl moiety of R30is substitutedwith one or more substituents independently selected from OH and Ci-CsalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0347] In some embodiments, the alkylene moiety of R30(e.g., optionally substituted C1- CealkyleneOCi-Cealkyl) is C-i-Cealkylene. In some embodiments, the alkylene moiety of R30is C1- Csalkylene. In some embodiments, the alkylene moiety of R30is Ci-C4alkylene. In some embodiments, the alkylene moiety of R30is Ci-C3alkylene. In some embodiments, the alkylene moiety of R30is Ci-C2alkylene. In some embodiments, the alkylene moiety of R30is C2-C6alkylene. In some embodiments, the alkylene moiety of R30is C2-C5alkylene. In some embodiments, the alkylene moiety of R30is C2-C4alkylene. In some embodiments, the alkylene moiety of R30is C2- C3alkylene. In some embodiments, the alkylene moiety of R30is C3-Cealkylene. In some embodiments, the alkylene moiety of R30is Cs-Csalkylene. In some embodiments, the alkylene moiety of R30is C3-C4alkylene. In some embodiments, the alkylene moiety of R30is C4-Cealkylene. In some embodiments, the alkylene moiety of R30is C4-Csalkylene. In some embodiments, the alkylene moiety of R30is Cs-Cealkylene.

[0348] In some embodiments, the alkylene moiety of R30is selected from alkylene, deuteroalkylene, haloalkylene, and deuterohaloalkylene, including any member, combination, or subset thereof. In some embodiments, none of the available hydrogen atoms of the alkylene moiety of R30are replaced by a halogen atom and none of the available atoms of the alkylene moiety of R30are replaced by an alternative isotope thereof. In some embodiments, the alkylene moiety of R30is unsubstituted Ci-Cgalkylene. In some embodiments, the alkylene moiety of R30is substituted Ci-Csalkylene. In some embodiments, the alkylene moiety of R30is substituted with one or more substituents independently selected from OH and Ci-CgalkyleneOH (e.g., CH2OH), including any member, combination, or subset thereof.

[0349] In some embodiments, R30is optionally substituted Ci-Cealkyl. In some embodiments, R30is selected from methyl, ethyl, isopropyl, and tert-butyl, including any member, combination, or subset thereof.

[0350] In some embodiments, R30is selected from CH3, CD2H, CDH2, CD3, CF2H, CFH2, CF3, CH2CH3, CH2CH2F, CH2CF2H, CH2CF3]CF2CF3, CH2CH2D, CH2CD2H, CH2CD3, CD2CD3ICH2CH2CH3, CH2CH2CHF2, CH2CH2CFH2, CH2CH2CF3, CH2CH2CHD2, CH2CH2CDH2ICH2CH2CD3, CH(CH3)2, CH(CF3)2, CH(CHF2)2, CH(CFH2)2, CH(CD3)2, CH(CHD2)2, CH(CDH2)2IC(CH3)3, C(CF3)3, C(CHF2)3, C(CFH2)3, C(CD3)3, C(CHD2)3, C(CDH2)3ICH2CH2CH2CH3ICH2CH2CH2CF3ICH2CH2CH2CD3, CH2CH(CH3)2, CH2CH(CD3)2, CH2CH(CF3)21CH(CH3)CH2CH3ICH(CH3)CH2CF3, CH(CH3)CH2CD3, CH2CH(CH3)CH3, CH2CH(CH3)CF31CH2CH(CH3)CD3, CH2C(CH3)3ICH2C(CF3)3JCH2C(CD3)3, CH2CH2C(CH3)3, CH2CH2C(CF3)3, and CH2CH2C(CD3)3, including any member, combination, or subset thereof. In some embodiments, R30is selected from CH3, CH2D, CHD2, CD3, CH2F, CHF2, CF3, CH2CH3, CD2CD3, CF2CF3, CH(CH3)2, CH(CD3)2ICH(CF3)2, CD(CD3)2, CF(CF3)2, C(...

Claims

1. WHAT IS CLAIMED IS:1 . A compound of Formula (I) or a stereoisomer thereof:or a pharmaceutically acceptable salt, solvate, and / or prodrug thereof, wherein:Xais selected from CR5and N;Xbis selected from CR6and N;R1is selected from halogen, OH, optionally substituted OCi-Cealkyl, optionally substituted OC(O)Ci-Cealkyl, optionally substituted OC(O)Ci-C6alkyleneC(O)OR33, optionally substituted OC(O)Ci-C24alkenyl, SH, optionally substituted SCi-C6alkyl, optionally substituted S(O)(Ci- C6alkyl), optionally substituted S(O)2(Ci-C6alkyl), optionally substituted SC(O)Ci- C6alkyleneC(O)OR33, OP(O)(OH)2]optionally substituted C3-Ci0cycloalkyl, optionally substituted 3- to 10-membered heterocycloalkyl, optionally substituted 5- to 10-membered heteroaryl, optionally substituted 0-(C3-Ciocycloalkyl), optionally substituted O-(3- to 10- membered)heterocycloalkyl, andor a stereoisomer thereof;R2is selected from H, D, halogen, and optionally substituted Ci-C6alkyl;R3is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;R4is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;Rsis selected from H, D, halogen, and optionally substituted Ci -Cealkyl ;R6is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;R7is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;Q is selected from:over a bond means that the bond is attached to a remaining portion of the compound;R8is selected from optionally substituted Ci-CBalkyl and optionally substituted Cs-Cscycloalkyl;R9is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted C3- Cscycloalkyl;R10is selected from H, D, halogen, and optionally substituted Ci-CBalkyl, and R11is selected from H, D, halogen, and optionally substituted Ci-CBalkyl; ortogether form a carbonyl group having a structureR12is selected from H, D, halogen, and optionally substituted Ci-CBalkyl, and R13is selected from H, D, halogen, and optionally substituted Ci-CBalkyl; ortogether form a carbonyl group having a structureR14is selected from H, D, halogen, and optionally substituted Ci-CBalkyl, and R15is selected from H, D, halogen, and optionally substituted Ci-CBalkyl; ortogether form a carbonyl group having a structureR16is selected from H, D, optionally substituted Ci-CBalkyl, and optionally substituted C-i- C6alkyleneOCi-C6alkyl;R17is selected from halogen, optionally substituted Ci-C6alkyl, OH, optionally substituted OCi- C6alkyl, SH, and optionally substituted SCi-CBalkyl;R18is selected from H, D, halogen, and optionally substituted Ci-CBalkyl, and R19is selected from H, D, halogen, and optionally substituted Ci-CBalkyl; ortogether form a carbonyl group having a structureR20is selected from H, D, halogen, and optionally substituted Ci-Cealkyl, and R21is selected from H, D, halogen, and optionally substituted Ci-Cealkyl; ortogether form a carbonyl group having a structureR22is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OCi- Cealkyl, SH, and optionally substituted SCi-Cgalkyl;R23is selected from H, D, halogen, and optionally substituted Ci-C6alkyl, and R24is selected from H, D, halogen, and optionally substituted Ci-Cealkyl;together form a carbonyl group having a structureR25is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted Ci- CealkyleneOCi-Cealkyl;R26is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC1- Cealkyl, SH, and optionally substituted SCi-Cealkyl;R27is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC1- Cealkyl, SH, and optionally substituted SCi-Cealkyl;R28is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted Cr CealkyleneOCi-Csalkyl;R29is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OC1- Cealkyl, SH, and optionally substituted SCi-Cealkyl;R30is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted Ci- CealkyleneOCi-Csalkyl;R31is selected from halogen, optionally substituted Ci-Cealkyl, OH, optionally substituted OCi- Cealkyl, SH, and optionally substituted SCi-Cealkyl;R32is selected from H, D, optionally substituted Ci-Cealkyl, and optionally substituted Ci- CealkyleneOCi-Cealkyl;R33is selected from H, D, and optionally substituted C-i-Cealkyl; k is selected from 0 and 1 ; m is selected from 0 and 1 ; n is selected from 0 and 1 ; p is selected from 0 and 1 ; q is selected from 0 and 1 ; r is selected from 0 and 1 ; one or more available hydrogen atoms are optionally and independently replaced with one or more respective halogen atoms and / or one or more available atoms are optionally and independently replaced with one or more respective alternative isotopes thereof, none of R8, R9, R16, R25, R28, R30, R32, and R33consist of only a halogen atom; and the compound of Formula (I) is not selected from:2-(8-methoxynaphthalen-1 -yl)-N,N-dimethylethan-1 -amine;8-(2-(dimethylamino)ethyl)naphthalen-1-ol;N,N-diethyl-2-(8-methoxynaphthalen-1-yl)ethan-1 -amine;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-propylpropan-1 -amine;N-isopropyl-N-(2-(8-methoxynaphthalen-1-yl)ethyl)propan-2-amine;N-ethyl-2-(8-methoxynaphthalen-1 -yl)-N-methylethan-1 -amine;8-(2-(ethyl(methyl)amino)ethyl)naphthalen-1-ol;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-methylpropan-1 -amine;N-(2-(8-methoxynaphthalen-1 -yl)ethyl)-N-methylpropan-2 -amine;8-(2-(isopropyl(methyl)amino)ethyl)naphthalen-1-ol;2-(8-methoxynaphthalen-1 -yl)-N-methylethan-1 -amine;2-(8-fl u oronaphtha len - 1 -yl)-N-methylethan-1 -amine;2-(8-chloronaphthalen-1 -yl)-N-methylethan-1 -amine; and2-(8-bromonaphthalen-1 -yl)-N-methylethan-1 -amine.

2. The compound of claim 1, wherein:(a) when Xaand Xbare CR5and CR6, respectively, then R5and R6are not both H; or(b) Xais N; or(c) Xbis N; or(d) R3is not H; or(e) R7is not H; or(f) R1is neither OH nor optionally substituted OCi-Cealkyl; or(g) R1is OC(O)Ci-C6alkyleneC(O)OR33; or(h) Q is not Q1 ; or(i) any combination of two or more of (a), (b), (c), (d), (e), (f), (g), and (h).

3. The compound of claim 1 or claim 2, provided that when Xais CR5, Xbis CR6, and Q is selected from Q5, Q6, and Q7, then:R2-R7are all H not replaced with a halogen atom; and / or none of the substituents selected from R2-R7are selected from F, OH, and OCH3; and / or at least two of the substituents selected from R2-R7are selected from F, OH, and OCH3.

4. The compound of claim 1 or claim 2, provided that when Xais CR5, Xbis CR6, Q is Q1 , R1is OH or OCH3, R2to R7and R10to R13are each H, then R8and / or R9are independently selected from non-deuterated non-halogenated Cs-Cealkyl, deuterated Cs-Cealkyl, halogenated Cs-Cealkyl, and deuterated halogenated Cs-Cealkyl.

5. The compound of any one of claims 1 to 3, wherein one or more available hydrogen atoms are optionally and independently replaced with one or more respective fluorine atoms and / or one or more available atoms are optionally and independently replaced with one or more respective isotope atoms.

6. The compound of any one of claims 1 to 4, wherein one or more available hydrogen atoms are optionally and independently replaced with one or more respective deuterium atoms.

7. The compound of any one of claims 1 to 4, wherein the compound is non-deuterated.

8. The compound of any one of claims 1 to 6, wherein Xais CR5.

9. The compound of any one of claims 1 to 6, wherein Xais N.

10. The compound of any one of claims 1 to 8, wherein Xbis CR6.11 . The compound of any one of claims 1 to 8, wherein Xbis N.

12. The compound of any one of claims 1 to 10, wherein R1is selected from cyclopropyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, OH, OCH3, OCHF2, O-cyclopentyl, OC(O)CH3, OC(O)(CH2)2C(O)OH, OC(O)(CH2)3C(O)OH, O-tetrahydrofuranyl,OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, SCH3, SCF3, SC(O)(CH2)3C(O)OH, S(O)CH3, S(O)2CH3, and13. The compound of any one of claims 1 to 11 , wherein R2is hydrogen not replaced with a halogen atom or an alternative isotope thereof.

14. The compound of any one of claims 1 to 12, wherein R3is hydrogen not replaced with a halogen atom or an alternative isotope thereof.

15. The compound of any one of claims 1 to 13, wherein R4is hydrogen not replaced with a halogen atom or an alternative isotope thereof.

16. The compound of any one of claims 1 to 14, wherein R5is hydrogen not replaced with a halogen atom or an alternative isotope thereof.

17. The compound of any one of claims 1 to 15, wherein R6is hydrogen not replaced with a halogen atom or an alternative isotope thereof.

18. The compound of any one of claims 1 to 16, wherein R7is hydrogen not replaced with a halogen atom or an alternative isotope thereof.

19. The compound of claim 1, having a structure of Formula (l-A-ii):(l-A-ii), wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from cyclopropyl, tetrahydrofuranyl, oxazolyl, thiazolyl, pyridinyl, OH, OCH3, OCHF2, O-cyclopentyl, OC(O)(CH2)2C(O)OH, OC(O)(CH2)3C(O)OH, O-tetrahydrofuranyl, OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, SCH3, SCF3, SC(O)(CH2)3C(O)OH, S(O)CH3, S(O)2CH3IandR8is selected from CH3, CD3, CH2CH3, and CH(CH3)2;R9is selected from H, CH3, CD3, CH2CH3, and CH(CH3)2;R10is selected from H and D;R11is selected from H and D;R12is selected from H, D, and CH3;R13is selected from H and D; andnone of the available hydrogen atoms of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13are replaced with respective halogen atoms and none of the available atoms of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13are replaced with respective alternative isotopes thereof.

20. The compound of claim 1, having a structure of Formula (l-B-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from OH, OCH3, OCHF2, OC(O)CH3, OC(O)(CH2)2C(O)OH, OC(O)(CH2)3C(O)OH,OC(O)(CH2)7CH=CHCH2CH=CH(CH2)4CH31OP(O)(OH)2, SCH3IandR16is selected from H, CH3, and CH2CH2OCH3; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

21. The compound of claim 1, having a structure of Formula (l-C-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from OH, OCH3, OC(O)(CH2)7CHCH=CH2CH=CH(CH2)4CH3, OP(O)(OH)2, SH, and SCH3;R22is selected from OH, OCH3, OCHF2, and OCF3; m is 0 or 1 ; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

22. The compound of claim 1, having a structure of Formula (l-D-ii):(l-D-ii), wherein:Xais selected from CH and N;Xbis selected from CH and N;R1is selected from OH, OCH3, OCHF2, OP(O)(OH)2, andR25is selected from H and CH3; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

23. The compound of claim 1, having a structure of Formula (l-E-ii):R28is selected from H, CH3, and CH2CH3; and none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

24. The compound of claim 1, having a structure of Formula (l-F-ii):wherein:Xais selected from CH and N;Xbis selected from CH and N;none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

25. The compound of claim 1, having a structure of Formula (l-G-ii):none of the available hydrogen atoms are replaced with respective halogen atoms and none of the available atoms are replaced with respective alternative isotopes thereof.

26. The compound of claim 1, wherein the compound is selected from the following:2-((8-methoxynaphthalen-1 -yl)methyl)pyrrolidine;(R)-2-(2,5-dimethoxy-4(R)-2-((8-methoxynaphthalen-1-yl)methyl)pyrrolidine;(S)-2-(2,5-dimethoxy-4(R)-2-((8-methoxynaphthalen-1-yl)methyl)pyrrolidine;(R)-2-((8-(difluoromethoxy)naphthalen-1-yl)methyl)pyrrolidine;(S)-2-((8-(difluoromethoxy)naphthalen-1-yl)methyl)pyrrolidine;8-(2-(diisopropylamino)ethyl)naphthalene-1 -thiol;N-isopropyl-N-(2-(8-(methylthio)naphthalen-1-yl)ethyl)propan-2-amine;N,N-dimethyl-2-(8-(methylthio)naphthalen-1-yl)ethan-1 -amine;(S)-1 -methyl-2-((8-(methylthio)naphthalen-1-yl)methyl)pyrrolidine;(R)-1 -methyl-2-((8-(methylthio)naphthalen-1-yl)methyl)pyrrolidine;8-(pyrrolidin-2-ylmethyl)naphthalen-1-ol;(R)-8-(pyrrolidin-2-ylmethyl)naphthalen-1-ol;(S)-8-(pyrrolidin-2-ylmethyl)naphthalen-1-ol;(R)-8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl dihydrogen phosphate;(S)-8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl dihydrogen phosphate;2-((8-methoxynaphthalen-1 -yl)methyl)azetidine;(R)-8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl acetate;(S)-8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl acetate;(R)-4-((8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl)oxy)-4-oxobutanoic acid;(S)-4-((8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl)oxy)-4-oxobutanoic acid;4-((8-(2-(dimethylamino)ethyl)naphthalen-1 -yl)oxy)-4-oxobutanoic acid;5-((8-(2-(dimethylamino)ethyl)naphthalen-1 -yl)oxy)-5-oxopentanoic acid;(S)-2-((8-methoxynaphthalen-1-yl)methyl)azetidine;(R)-2-((8-methoxynaphthalen-1-yl)methyl)azetidine;(S)-2-((8-(difluoromethoxy)naphthalen-1-yl)methyl)azetidine;(R)-2-((8-(difluoromethoxy)naphthalen-1-yl)methyl)azetidine;8-(azetidin-2-ylmethyl)naphthalen-1 -ol;(S)-5-((8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(R)-5-((8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;5-((8-(2-(bis(methyl-d3)amino)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;8-(2-(dimethylamino)ethyl)naphthalen-1 -yl (9Z,12Z)-octadeca-9,12-dienoate;8-(((S)-1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;(S)-8-(azetidin-2-ylmethyl)naphthalen-1 -ol;(R)-8-(azetidin-2-ylmethyl)naphthalen-1 -ol;(S)-8-((1 -methylazetidin-2-yl)methyl)naphthalen-1 -yl dihydrogen phosphate;(R)-8-((1 -methylazetidin-2-yl)methyl)naphthalen-1-yl dihydrogen phosphate;8-(((R)-1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;8-((R)-2-(dimethylamino)propyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;8-((S)-2-(dimethylamino)propyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;8-(2-(diisopropylamino)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;3-(8-methoxynaphthalen-1 -yl)azetidine;3-(8-methoxynaphthalen-1 -yl)-1 -methylazetidine;(1 -ethyl-3-(8-methoxynaphthalen-1 -yl)azetidine;8-(2-(isopropyl(methyl)amino)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;8-(2-(diethylamino)ethyl)naphthalen-1 -yl (9Z,12Z)-octadeca-9,12-dienoate;8-(2-(py rrol id i n - 1 -yl)ethyl)naphthalen-1 -yl (9Z, 12Z)-octadeca-9, 12-dienoate;3-(8-(difluoromethoxy)naphthalen-1-yl)azetidine;2-(8-(difluoromethoxy)naphthalen-1 -yl)-N,N-bis(methyl-d3)ethan-1 -amine;2-(8-(difluoromethoxy)naphthalen-1 -yl)-N-(methyl-d3)ethan-1 -amine;8-(2-((R)-3-methoxypyrrolidin-1 -yl)ethyl)naphthalen-1 -yl (9Z,12Z)-octadeca-9, 12-dienoate;8-(2-((S)-3-methoxypyrrolidin-1-yl)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;8-(2-((R)-3-(trifluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12- dienoate;8-(2-(dimethylamino)ethyl)naphthalen-1-yl dihydrogen phosphate;8-(2-(dimethylamino)ethyl-2,2-d2)naphthalen-1-ol;8-(2-(methylamino)ethyl-2,2-d2)naphthalen-1-ol;8-(2-((R)-3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12- dienoate;8-(2-((S)-3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12- dienoate;8-(2-((S)-3-(trifluoromethoxy)pyrrolidin-1 -yl)ethyl)naphthalen-1 -yl (9Z, 12Z)-octadeca-9, 12- dienoate;8-(2-(dimethylamino)ethyl-1 ,1 ,2,2-d4)naphthalen-1 -ol;8-(2-(bis(methyl-d3)amino)ethyl-1 ,1 ,2,2-d4)naphthalen-1-ol;8-(2-(bis(methyl-d3)amino)ethyl-1 ,1 ,2,2-d4)naphthalen-1-yl dihydrogen phosphate;8-(2-((R)-3-hydroxypyrrolidin-1 -yl)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;8-(2-((S)-3-hydroxypyrrolidin-1 -yl)ethyl)naphthalen-1-yl (9Z,12Z)-octadeca-9,12-dienoate;(2S,3R,4R,5S,6R)-2-((8-(2-(dimethylamino)ethyl)naphthalen-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;8-(2-(bis(methyl-d3)amino)ethyl-2,2-d2)naphthalen-1 -yl dihydrogen phosphate;8-(2-(bis(methyl-d3)amino)ethyl)naphthalen-1 -yl dihydrogen phosphate;8-(2-(bis(methyl-d3)amino)ethyl)naphthalen-1 -yl dihydrogen phosphate;8-(2-(methylamino)ethyl)naphthalen-1 -yl dihydrogen phosphate;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-(((S)-1-methylpyrrolidin-2-yl)methyl)naphthalen-1- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-(((R)-1-methylpyrrolidin-2-yl)methyl)naphthalen-1- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-(((R)-pyrrolidin-2-yl)methyl)naphthalen-1- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-(((S)-pyrrolidin-2-yl)methyl)naphthalen-1- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;8-(2-(pyrrolid i n - 1 -yl)ethyl)naphthalen-1 -yl dihydrogen phosphate;(R)-8-(2-(3-methoxypyrrolidin-1 -yl)ethyl)naphthalen-1 -yl dihydrogen phosphate;(S)-8-(2-(3-methoxypyrrolidin-1-yl)ethyl)naphthalen-1-yl dihydrogen phosphate;(R)-8-(2-(3-(difluoromethoxy)pyrrolidin-1 -yl)ethyl)naphthalen-1 -yl dihydrogen phosphate;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-((R)-pyrrolidin-3-yl)naphthalen-1-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-((S)-pyrrolidin-3-yl)naphthalen-1-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-((S)-piperidin-3-yl)naphthalen-1-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((8-((R)-piperidin-3-yl)naphthalen-1-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(S)-8-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-yl dihydrogen phosphate;(R)-8-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-ol;;(S)-8-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-ol(S)-8-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalene-1 -thiol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((S)-piperidin-3-yl)isoquinolin-4-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-((8-(((S)-azetidin-2-yl)methyl)naphthalen-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-((8-(((R)-azetidin-2-yl)methyl)naphthalen-1-yl)oxy)-6- (hydraxymethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-((8-(azetidin-3-yl)naphthalen-1-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H- pyran-3,4,5-triol;(R)-8-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalene-1 -thiol;(R)-3-(difluoromethoxy)-1 -(2-(8-(methylthio)naphthalen-1-yl)ethyl)pyrrolidine;(S)-3-(difluoromethoxy)-1 -(2-(8-(methylthio)naphthalen-1-yl)ethyl)pyrrolidine;2-(8-(cyclopentyloxy)naphthalen-1 -yl)-N,N-dimethylethan-1 -amine;2-(8-(cyclopentyloxy)naphthalen-1 -yl)-N,N-bis(methyl-d3)ethan-1 -amine;(S)-N,N-bis(methyl-d3)-2-(8-((tetrahydrofuran-3-yl)oxy)naphthalen-1-yl)ethan-1 -amine;1 -(2-(8-(methylthio)naphthalen-1 -yl )ethyl )pyrrol id ine ;N,N-diethyl-2-(8-(methylthio)naphthalen-1-yl)ethan-1 -amine;8-(2-(diethylamino)ethyl)naphthalene-1 -thiol;(R)-N,N-dimethyl-2-(8-(tetrahydrofuran-3-yl)naphthalen-1-yl)ethan-1 -amine;(R)-N,N-bis(methyl-d3)-2-(8-((tetrahydrofuran-3-yl)oxy)naphthalen-1-yl)ethan-1 -amine;N,N-dimethyl-2-(8-((trifluoromethyl)thio)naphthalen-1-yl)ethan-1 -amine;2-(8-cyclopropylnaphthalen-1-yl)-N,N-dimethylethan-1 -amine;(S)-N,N-dimethyl-2-(8-(tetrahydrofuran-3-yl)naphthalen-1-yl)ethan-1 -amine;N,N-dimethyl-2-(8-(oxazol-4-yl)naphthalen-1-yl)ethan-1 -amine;N,N-dimethyl-2-(8-(pyridin-2-yl)naphthalen-1-yl)ethan-1 -amine;N,N-dimethyl-2-(8-(thiazol-4-yl)naphthalen-1-yl)ethan-1 -amine;N,N-dimethyl-2-(8-(pyridin-3-yl)naphthalen-1-yl)ethan-1 -amine;(S)-3-(difluoromethoxy)-1 -(2-(8-methoxynaphthalen-1-yl)ethyl)pyrrolidine;(R)-1 -(2-methoxyethyl)-2-((8-methoxynaphthalen-1-yl)methyl)pyrrolidine;N-ethyl-N-methyl-2-(8-(methylthio)naphthalen-1-yl)ethan-1 -amine;(R)-5-(difluoromethoxy)-4-(pyrrolidin-2-ylmethyl)quinoline;(R)-5-methoxy-4-(pyrrolidin-2-ylmethyl)quinoline;(R)-5-methoxy-4-(pyrrolidin-2-ylmethyl)cinnoline;(R)-5-methoxy-4-(pyrrolidin-2-ylmethyl)isoquinoline;(R)-5-(difluoromethoxy)-4-(pyrrolidin-2-ylmethyl)cinnoline;(R)-5-(difluoromethoxy)-4-(pyrrolidin-2-ylmethyl)isoquinoline;N-isopropyl-N-(2-(5-(methylthio)quinolin-4-yl)ethyl)propan-2-amine;N-isopropyl-N-(2-(5-(methylthio)cinnolin-4-yl)ethyl)propan-2-amine;N-isopropyl-N-(2-(5-(methylthio)isoquinolin-4-yl)ethyl)propan-2-amine;N-ethyl-N-methyl-2-(5-(methylthio)isoquinolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylthio)quinolin-4-yl)ethan-1 -amine;(S)-4-(azetidin-2-ylmethyl)-5-methoxyquinoline;(S)-4-(azetidin-2-ylmethyl)-5-methoxycinnoline;(S)-4-(azetidin-2-ylmethyl)-5-methoxyisoquinoline;4-(2-(dimethylamino)ethyl)quinolin-5-yl (9Z,12Z)-octadeca-9,12-dienoate;4-(2-(dimethylamino)ethyl)cinnolin-5-yl (9Z,12Z)-octadeca-9,12-dienoate;4-(2-(dimethylamino)ethyl)isoquinolin-5-yl (9Z,12Z)-octadeca-9,12-dienoate;(S)-4-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)-5-methoxyquinoline;(S)-4-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)-5-methoxycinnoline;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-(((R)-1-methylpyrrolidin-2-yl)methyl)quinolin-4- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-(((R)-1-methylpyrrolidin-2-yl)methyl)cinnolin-4- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-(((R)-1-methylpyrrolidin-2-yl)methyl)isoquinolin-4- yl)oxy)tetrahydro-2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((S)-piperidin-3-yl)isoquinolin-4-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((S)-piperidin-3-yl)cinnolin-4-yl)oxy)tetrahydro-2H- pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((S)-piperidin-3-yl)quinolin-4-yl)oxy)tetrahydro-2H- pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((R)-piperidin-3-yl)quinolin-4-yl)oxy)tetrahydro-2H- pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((R)-piperidin-3-yl)cinnolin-4-yl)oxy)tetrahydro-2H- pyran-3,4,5-triol;(2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-((5-((R)-piperidin-3-yl)isoquinolin-4-yl)oxy)tetrahydro- 2H-pyran-3,4,5-triol;(R)-N,N-bis(methyl-d3)-2-(5-((tetrahydrofuran-3-yl)oxy)quinolin-4-yl)ethan-1 -amine;(R)-N,N-bis(methyl-d3)-2-(5-((tetrahydrofuran-3-yl)oxy)cinnolin-4-yl)ethan-1 -amine;(R)-N,N-bis(methyl-d3)-2-(5-((tetrahydrofuran-3-yl)oxy)isoquinolin-4-yl)ethan-1 -amine;(S)-5-((1 -methylazetidin-2-yl)methyl)quinolin-4-yl dihydrogen phosphate;(S)-5-((1 -methylazetidin-2-yl)methyl)cinnolin-4-yl dihydrogen phosphate;(S)-5-((1 -methylazetidin-2-yl)methyl)isoquinolin-4-yl dihydrogen phosphate;N-isopropyl-N-(2-(8-(methylsulfinyl)naphthalen-1-yl)ethyl)propan-2-amine;N-isopropyl-N-(2-(8-(methylsulfonyl)naphthalen-1-yl)ethyl)propan-2-amine;N-ethyl-N-methyl-2-(8-(methylsulfonyl)naphthalen-1-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylsulfonyl)cinnolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylsulfonyl)quinolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylsulfonyl)isoquinolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylsulfinyl)isoquinolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylsulfinyl)cinnolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylthio)cinnolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylthio)isoquinolin-4-yl)ethan-1 -amine;N-ethyl-N-methyl-2-(5-(methylthio)quinolin-4-yl)ethan-1 -amine;5-((8-(2-(ethyl(methyl)amino)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;5-((8-(2-(dimethylamino)ethyl)naphthalen-1-yl)thio)-5-oxopentanoic acid;(R)-4-((1 -methylpyrrolidin-2-yl)methyl)quinolin-5-yl dihydrogen phosphate;(R)-4-((1 -methylpyrrolidin-2-yl)methyl)cinnolin-5-yl dihydrogen phosphate;(R)-4-((1 -methylpyrrolidin-2-yl)methyl)isoquinolin-5-yl dihydrogen phosphate;5-((4-(2-(dimethylamino)ethyl)cinnolin-5-yl)oxy)-5-oxopentanoic acid;5-((4-(2-(dimethylamino)ethyl)quinolin-5-yl)oxy)-5-oxopentanoic acid;5-((4-(2-(dimethylamino)ethyl)isoquinolin-5-yl)oxy)-5-oxopentanoic acid;(R)-N,N-dimethyl-2-(8-((tetrahydrofuran-3-yl)oxy)naphthalen-1-yl)ethan-1 -amine;(R)-N,N-dimethyl-2-(5-((tetrahydrofuran-3-yl)oxy)quinolin-4-yl)ethan-1 -amine;(R)-N,N-dimethyl-2-(5-((tetrahydrofuran-3-yl)oxy)cinnolin-4-yl)ethan-1 -amine;(R)-N,N-dimethyl-2-(5-((tetrahydrofuran-3-yl)oxy)isoquinolin-4-yl)ethan-1 -amine;(R)-5-oxo-5-((8-(pyrrolidin-2-ylmethyl)naphthalen-1-yl)oxy)pentanoic acid;(R)-5-oxo-5-((4-(pyrrolidin-2-ylmethyl)quinolin-5-yl)oxy)pentanoic acid;(R)-5-oxo-5-((4-(pyrrolidin-2-ylmethyl)cinnolin-5-yl)oxy)pentanoic acid;(R)-5-oxo-5-((4-(pyrrolidin-2-ylmethyl)isoquinolin-5-yl)oxy)pentanoic acid;2-(8-(difluoromethoxy)naphthalen-1-yl)-N,N-dimethylethan-1 -amine;2-(8-(difluoromethoxy)naphthalen-1 -yl)-N-methylethan-1 -amine;8-(2-(ethyl(methyl)amino)ethyl)naphthalen-1 -yl dihydrogen phosphate;2-(8-(cyclopentyloxy)naphthalen-1-yl)-N,N-dimethylethan-1 -amine;(S)-N,N-dimethyl-2-(8-((tetrahydrofuran-3-yl)oxy)naphthalen-1-yl)ethan-1 -amine;(S)-N,N-dimethyl-2-(5-((tetrahydrofuran-3-yl)oxy)quinolin-4-yl)ethan-1 -amine;(R)-8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-ol;(R)-8-(pyrrolidin-2-ylmethyl)naphthalen-1-ol;(S)-8-((1 -methylpyrrolidin-2-yl)methyl)naphthalen-1-ol;(S)-8-(pyrrolidin-2-ylmethyl)naphthalen-1-ol;(R)-2-((8-methoxynaphthalen-1-yl)methyl)-1-methylpyrrolidine;(S)-2-((8-methoxynaphthalen-1 -yl)methyl)-1 -methylpyrrolidine;(R)-5-((8-(2-(3-(difluoromethoxy)pyrrolidin-1-yl)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(S)-5-((8-(2-(3-(difluoromethoxy)pyrrolidin-1 -yl)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(R)-5-((8-(2-(3-methoxypyrrolidin-1-yl)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(S)-5-((8-(2-(3-methoxypyrrolidin-1-yl)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;5-((8-(1 -methylpyrrolidin-3-yl)naphthalen-1 -yl)oxy)-5-oxopentanoic acid;8-(1-methylpyrrolidin-3-yl)naphthalen-1 -yl dihydrogen phosphate;5-((8-(1 -methylpiperidin-3-yl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;8-(1-methylpiperidin-3-yl)naphthalen-1-yl dihydrogen phosphate;(R)-8-((1 -(2-methoxyethyl)pyrrolidin-2-yl)methyl)naphthalen-1-ol;(S)-8-((1 -(2-methoxyethyl)pyrrolidin-2-yl)methyl)naphthalen-1-ol;(R)-1 -(2-methoxyethyl)-2-((8-methoxynaphthalen-1-yl)methyl)pyrrolidine;(S)-1 -(2-methoxyethyl)-2-((8-methoxynaphthalen-1-yl)methyl)pyrrolidine;(R)-8-((1 -(2-methoxyethyl)pyrrolidin-2-yl)methyl)naphthalen-1 -yl dihydrogen phosphate;(S)-8-((1 -(2-methoxyethyl)pyrrolidin-2-yl)methyl)naphthalen-1 -yl dihydrogen phosphate;(R)-5-((8-((1 -(2-methoxyethyl)pyrrolidin-2-yl)methyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(S)-5-((8-((1 -(2-methoxyethyl)pyrrolidin-2-yl)methyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;5-oxo-5-((8-(2-(pyrrolidin-1 -yl)ethyl)naphthalen-1 -yl)oxy)pentanoic acid;8-(2-(pyrrolidin-1-yl)ethyl)naphthalen-1-ol;(R)-8-(2-(3-methoxypyrrolidin-1 -yl)ethyl)naphthalen-1 -ol;(S)-8-(2-(3-methoxypyrrolidin-1-yl)ethyl)naphthalen-1-ol;(R)-8-(2-(3-fluoropyrrolidin-1 -yl)ethyl)naphthalen-1-ol;(S)-8-(2-(3-fluoropyrrolidin-1 -yl)ethyl)naphthalen-1-ol;(R)-5-((8-(2-(3-fluoropyrrolidin-1 -yl)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(S)-5-((8-(2-(3-fluoropyrrolidin-1 -yl)ethyl)naphthalen-1-yl)oxy)-5-oxopentanoic acid;(R)-8-(2-(3-fluoropyrrolidin-1 -yl)ethyl)naphthalen-1-yl dihydrogen phosphate; and(S)-8-(2-(3-fluoropyrrolidin-1 -yl)ethyl)naphthalen-1-yl dihydrogen phosphate, or a pharmaceutically acceptable salt, solvate, and / or prodrug thereof.

27. A composition comprising one or more compounds of any one of claims 1 to 26 and a carrier.

28. A method of treating a depressive disorder, bipolar disorder, eating disorder, impulse control disorder, personality disorder, substance abuse disorder, behavioral addiction disorder, alcohol use disorder, post-traumatic stress disorder, anxiety disorder, stress disorder, neurodevelopmental disorder, pain disorder, headache disorder, inflammatory disorder, injury- related disorder, neurodegenerative disorder, functional disorder, psychotic disorder, hyperkinetic movement disorder, age-related macular degeneration, atherosclerosis, dissociative disorders, genetic brain disorders, hyperprolactinemia, hypersomnia, obesity, phobias, apathy disorders, and / or burnout comprising administering a therapeutically effective amount of one or more compounds of any one of claims 1 to 26 and / or a composition of claim 27 to a subject in need thereof.

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