Composition for oral cavity

Abstract

Provided is composition for the oral cavity containing a polishing agent and a binder, wherein when PF3 is the maximum pressing stress in a 3 mm indentation test, and TF5 and TF10 are the pulling stress in a 5mm tension test and a 10 mm tension test respectively, (PF3) * (TF5) is 50 (gf) ^ 2 or more and less than 5000 (gf) ^ 2, and TF10 is 4.0 gf or more and 50 gf or less.

Description

Oral composition

[0001] The present invention relates to an oral composition.

[0002] Patent Document 1 (JP 2021-91654 A) describes a technology for improving the releasability of oral compositions from their containers. This document describes a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound (Claim 1). According to this document, a dentifrice composition can be provided that exhibits the effects of the water-soluble polyvalent metal salt, such as suppressing hypersensitivity, suppressing bad breath, and tightening the gums, while also having excellent moldability, making it easy to apply to a toothbrush, and inhibiting hardening over time, resulting in excellent releasability from the container even after storage. This dentifrice composition maintains its physical properties satisfactorily, and can also be formulated into a dentifrice composition with a relatively low or no abrasive content, ensuring a gentle, low-irritation brushing experience. It is particularly useful for suppressing hypersensitivity or bad breath and tightening the gums (paragraph 0011).

[0003] Japanese Patent Application Laid-Open No. 2021-91654

[0004] Through the investigations of the present inventors, it became clear that there is room for improvement in the product described in Patent Document 1 above in terms of improving the ease of squeezing it out of the tube container while also improving the cushioning effect when brushing teeth.

[0005] The present invention provides an oral composition that has an excellent balance between squeezability when squeezed out of a tube container and cushioning properties when brushing teeth.

[0006] According to the present invention, the following oral composition is provided: [1] An oral composition comprising an abrasive and a binder, wherein, when PF3 is the maximum pushing stress in a 3 mm indentation test measured by Method 1 below, and TF5 and TF10 are the tensile stresses in a 5 mm tensile test and a 10 mm tensile test measured by Method 2 below, respectively, (PF3) * (TF5) is 50 (gf)^2 or more and less than 5000 (gf)^2, and TF10 is 4.0 gf or more and 50 gf or less. (Method 1) Name of device: Rheometer Jig used: Pressure-sensitive shaft for measuring pressure / elasticity (Φ20 mm) Measurement speed: 60 mm / min Push-in distance: 3 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to capacity with the oral composition, and after setting it in the device, it is pushed to the pushing distance at the measurement speed, and the maximum stress during pushing is measured. The average value of three measurements is the PF3. (Method 2) Name of device: Rheometer Jig used: Pressure-sensitive shaft for measuring pressure / elasticity (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm or 10 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to capacity with the oral composition, and after setting it in the device, it is pulled up at the measurement speed, and the absolute value of the stress at each pulling distance is measured. The TF5 or TF10 is the average value of three measurements taken at each pull-up distance. [2] The oral composition according to [1], wherein the binder comprises thickening silica. [3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder. [4] The oral composition according to [3], wherein the organic binder is one or more selected from the group consisting of carboxymethylcellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan). [5] The oral composition according to any one of [1] to [4], wherein the abrasive comprises abrasive silica.[6] The oral composition according to any one of [1] to [5], further comprising a humectant. [7] The oral composition according to any one of [1] to [6], which is a dentifrice composition. [8] The oral composition according to any one of [1] to [7], which is a toothpaste composition. [9] A dentifrice, in which the oral composition according to any one of [1] to [8] is filled in a tube container.

[0007] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention.

[0008] According to the present invention, an oral composition can be obtained that has an excellent balance between ease of squeezing from a tube container and cushioning properties during tooth brushing.

[0009] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component alone or in combination of two or more. In this specification, the term "to" indicating a numerical range means "at least" or "at most," and both end values ​​are included.

[0010] (Oral Composition) In the present embodiment, the oral composition contains an abrasive and a binder. When the maximum pushing stress in a 3 mm indentation test measured by the following method 1 is defined as PF3, and the tensile stresses in a 5 mm tensile test and a 10 mm tensile test measured by the following method 2 are defined as TF5 and TF10, respectively, (PF3) * (TF5) is 50 (gf)^2 or more and less than 5000 (gf)^2, and TF10 is 4.0 gf or more and 50 gf or less.

[0011] (Method 1) Name of device: Rheometer (for example, CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure-sensitive shaft for pressure / elasticity measurement (Φ20 mm) Measurement speed: 60 mm / min Push-in distance: 3 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pushed to the push-in distance at the measurement speed, and the maximum stress during pushing is measured. The average value of three measurements is taken as PF3.

[0012] (Method 2) Name of device: Rheometer (for example, CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure-sensitive shaft for pressure / elasticity measurement (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm or 10 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: Fill the filling container to the top with the oral composition, set it in the device, and then pull it up at the measurement speed, measuring the absolute value of the stress at each pull-up distance. The average value of three measurements taken at each pull-up distance is designated as TF5 or TF10. In the procedure of Method 2, the numerical value of the stress during pull-up is a negative value, so the recorded value is a negative value and the absolute value is a positive value.

[0013] Here, the measurement temperature in Measurement 1 and Measurement 2 is specifically room temperature (25° C.).

[0014] The present inventors conducted research focusing on the ingredients and physical properties of oral compositions as design guidelines for improving the balance between the squeezability of the oral composition when squeezed from a tube container and the cushioning effect during toothbrushing. As a result, they discovered that by controlling the ingredients of the oral composition and using (PF3)*(TF5) and TF10 as indicators, it is possible to make the oral composition easier to squeeze from a tube container while providing suitable cushioning effect on the surfaces of teeth and gums during toothbrushing, thereby achieving a favorable balance of these effects. In other words, in this embodiment, the oral composition contains a combination of an abrasive and a binder, and (PF3)*(TF5) and TF10 are each within a specific range, resulting in an excellent balance of squeezability when squeezed from a tube container and cushioning effect during toothbrushing. This also makes it possible to obtain oral compositions that are easy to handle and have a good feel when used in the oral cavity. For example, it is possible to reduce the feeling of excessive hardness when squeezing the oral composition from a tube container and to suitably reduce dripping from the discharge port. It is also possible to improve the controllability of the amount of oral composition discharged from the tube container. Furthermore, when using the oral composition with a toothbrush, it is possible to reduce the feeling of irritation while providing a moderate massaging sensation with the toothbrush.

[0015] The product of the maximum pushing stress PF3 in a 3 mm indentation test and the pulling stress TF5 in a 5 mm tensile test, i.e., (PF3) * (TF5), is 50 (gf)^2 or more, preferably 80 (gf)^2 or more, more preferably 100 (gf)^2 or more, even more preferably 150 (gf)^2 or more, and even more preferably 200 (gf)^2 or more. This can reduce dripping of the oral composition filled in the tube container from the discharge outlet. It can also provide more preferable cushioning properties during tooth brushing. It can also provide a more preferable massage feeling when using a toothbrush. Furthermore, the product of the stresses (PF3) * (TF5) is less than 5000 (gf)^2, preferably 4000 (gf)^2 or less, more preferably 3000 (gf)^2 or less, even more preferably 2500 (gf)^2 or less, still more preferably 2000 (gf)^2 or less, and may be 1000 (gf)^2 or less. This reduces the feeling of excessive hardness when squeezing the oral composition filled in the tube container. Furthermore, the oral composition can be easily spread in the oral cavity.

[0016] PF3 is preferably 10 gf or more, more preferably 20 gf or more, even more preferably 30 gf or more, and even more preferably 40 gf or more. This allows for more preferable sharpness when discharging the oral composition filled in the tube container. Furthermore, PF3 is preferably 130 gf or less, more preferably 100 gf or less, even more preferably 80 gf or less, and even more preferably 60 gf or less. This allows for more improved dischargeability when squeezing out the oral composition filled in the tube container. Furthermore, the usability of the oral composition can be improved.

[0017] TF5 can be set to a value such that (PF3)*(TF5) falls within the above-mentioned range. TF5 may be, for example, 7 g or more, or may be, for example, 40 g or less.

[0018] The tensile stress TF10 in a 10 mm tensile test is 4.0 gf or more, preferably 5.0 gf or more, and more preferably 6.0 gf or more. This can improve the cushioning properties when brushing teeth. Also, the massaging feeling when brushing teeth can be made more preferable. Furthermore, TF10 is 50 gf or less, preferably 40 gf or less, more preferably 35 gf or less, even more preferably 30 gf or less, still more preferably 25 gf or less, and even more preferably 20 gf or less. This can improve the cushioning properties when brushing teeth. Also, the irritation caused by the toothbrush when using the oral composition together with the toothbrush can be reduced.

[0019] Next, the components of the oral composition will be described. As described above, the oral composition contains an abrasive and a binder.

[0020] (Abrasive) Examples of the abrasive include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolite; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, and quaternary calcium phosphate; and organic abrasives such as synthetic resin-based abrasives.

[0021] The abrasive preferably contains abrasive silica, more preferably hydrated silicic acid. It is also preferable to contain anhydrous silicic acid. This can more stably improve the balance between the ease of squeezing out of the tube container and the cushioning effect when brushing teeth. The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

[0022] The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, even more preferably 5 μm or more, and even more preferably 8 μm or more. This allows for efficient removal of stains from the tooth surface. The average particle size of the abrasive silica is also preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less. This allows for the production of an oral composition that is smooth to the touch.

[0023] Here, the average particle size of the abrasive silica and the thickening silica described below is determined by measuring the particle size distribution of the particles on a volume basis using a commercially available laser diffraction / scattering particle size distribution measuring device. 50 It can be said that:

[0024] It is also preferable that the abrasive is substantially free of calcium carbonate. This allows for a more stable improvement in the balance between the ease of squeezing the composition from the tube container and the cushioning effect during toothbrushing. Here, "the oral composition is free of calcium carbonate" specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001% by mass or less of the oral composition as a whole.

[0025] The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably 10% by mass or more, even more preferably more than 10% by mass, even more preferably 11% by mass or more, and even more preferably 13% by mass or more, based on the total oral composition. This allows for efficient removal of stains from the tooth surface. Furthermore, the content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total oral composition. This allows for an oral composition with excellent smoothness in use.

[0026] (Binder) Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrous silicic acid (e.g., gel silica, precipitated silica) and anhydrous silicic acid (e.g., gel silica, precipitated silica, and dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0027] The binder preferably contains an inorganic binder, more preferably contains thickening silica, which can more stably improve the balance between the squeezability when squeezed out of the tube container and the cushioning effect when brushing teeth.

[0028] The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica.The average particle size of the thickening silica is, for example, preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more.This allows the viscosity of the oral composition to be more efficiently maintained.In addition, the average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and even more preferably 40 μm or less.This allows the oral composition to have excellent smoothness when used.

[0029] The oil absorption of the thickening silica, as determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL / g or more, preferably 0.2 mL / g or more, and, for example, 5 mL / g or less, preferably 4 mL / g or less.

[0030] The content of the inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This makes it possible to obtain an oral composition with excellent cushioning properties during toothbrushing. This also reduces irritation caused by contact of the toothbrush with the teeth, gums, etc. Furthermore, the content of the inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total oral composition. This makes it possible to obtain an oral composition with excellent surface smoothness.

[0031] The binder preferably contains an organic binder. When the binder contains thickening silica, it is preferable that the binder further contains an organic binder. This makes it possible to more stably improve the balance between the ease of squeezing the powder from the tube container and the cushioning effect when brushing teeth.

[0032] In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan); more preferably, it comprises one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; even more preferably, it comprises two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; still more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum; and even more preferably, it comprises sodium alginate and xanthan gum. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0033] On the other hand, in terms of facilitating rinsing the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition not containing xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less of the entire oral composition.

[0034] The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total oral composition. This allows the oral composition to have an appropriate viscosity. Furthermore, the content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows the oral composition to be squeezed cleanly from a tube container.

[0035] The mass ratio of the organic binder content to the inorganic binder content in the oral composition (organic binder / inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more. This allows for an oral composition with a smooth texture and excellent usability. Furthermore, the mass ratio (organic binder / inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less. This allows for an oral composition with excellent cleanliness when dispensed from a tube container onto a toothbrush or the like. The total content of binders in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total oral composition. This allows for an appropriate viscosity to be imparted to the oral composition. The total content of the binder in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows for an oral composition that is more easily absorbed by saliva during tooth brushing. Furthermore, excessive thickening of the oral composition can be suppressed.

[0036] The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition. This allows the fluidity of the oral composition to be moderately suppressed. The total content of silica in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition. This allows the oral composition to be more easily mixed with saliva in the oral cavity, for example, when brushing teeth.

[0037] (Other Components) The oral composition may further contain components other than those described above. Such components include medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., and may be selected appropriately depending on the dosage form.

[0038] Examples of medicinal ingredients include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar inhibitors, stain removers, anti-hypersensitivity agents, vitamins, and plaque-decomposing enzymes. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals, etc.

[0039] Among the medicinal ingredients, examples of disinfectants include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0040] Examples of anti-inflammatory agents include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0041] Examples of the blood circulation promoter include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

[0042] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0043] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0044] The dentin hypersensitivity reducing agent may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0045] Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and derivatives thereof, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra-2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and derivatives thereof, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0046] An example of a plaque decomposing enzyme is dextranase.

[0047] The thickening agent may be, for example, a commercially available thickening agent used as a raw material for pharmaceuticals, foods, or cosmetics. The thickening agent may include, for example, one or more selected from the group consisting of polyhydric alcohols, more specifically, sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltite, lactite, trehalose, sodium hyaluronate, and hydrolyzed collagen.

[0048] Examples of surfactants include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters; nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amido alkyl betaine), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine). The surfactant may also be a foaming agent.

[0049] The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total oral composition. This allows for an oral composition that foams appropriately when brushing teeth. Furthermore, the content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total oral composition. This allows for an oral composition with cleansing power that does not excessively remove oil from the oral cavity.

[0050] The oral composition preferably further contains a humectant, which can improve the production stability of the oral composition. The humectant may be any humectant that is commercially available as a pharmaceutical, food, or cosmetic ingredient, such as a polyhydric alcohol, and more specifically, one or more selected from the group consisting of sorbitol (sorbitol), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0051] In terms of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, more preferably sorbitol or concentrated glycerin.

[0052] The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition. This allows for an oral composition with excellent moisturizing ability in the oral cavity. Furthermore, the content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total oral composition. This allows for an oral composition that is easy to rinse off with gargle.

[0053] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyltrehalose, or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0054] The flavoring agent is preferably at least one selected from the group consisting of xylitol, saccharin sodium, and saccharin, and more preferably at least one selected from the group consisting of xylitol and saccharin sodium, since it has a strong sweetness and can adjust the taste even with a small amount.

[0055] Examples of preservatives include one or more selected from the group consisting of parahydroxybenzoates such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

[0056] The flavoring agent may be, for example, one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

[0057] Examples of coloring agents include one or more selected from the group consisting of natural dyes such as safflower red dye, gardenia yellow dye, gardenia blue dye, perilla dye, red koji dye, red cabbage dye, carrot dye, hibiscus dye, cacao dye, spirulina blue dye, and coumarind dye; legally mandated dyes such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; riboflavin, and titanium dioxide.

[0058] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and buffering agents.

[0059] The solvent may be water, or a lower alcohol such as ethanol, propanol, etc. The solvent may be a liquid base.

[0060] The content of water in the oral composition can be, for example, the remainder after excluding components other than water from the oral composition. The content of water in the oral composition can be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, based on the total oral composition. It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or that the oral composition contains ethanol but the ethanol content is 5% by mass or less. This can suppress strong irritation to the oral cavity.

[0061] A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0062] Other bases include, for example, sodium bicarbonate.

[0063] Detergents include, for example, sodium polyphosphate.

[0064] The adsorbent may be, for example, β-cyclodextrin.

[0065] Furthermore, in addition to the above components, components generally suitable for use in oral compositions can also be appropriately blended within the scope of the present invention.

[0066] (Dosage form, etc.) Specific examples of oral compositions include dentifrices such as toothpaste. The oral composition is preferably a dentifrice composition, more preferably a toothpaste composition. This can further improve the ease of handling of the oral composition. From the same point of view, the oral composition is preferably in the form of a paste or gel.

[0067] The oral composition is preferably applied to the oral cavity by being placed on a toothbrush. Examples of toothbrushes that can be used with the oral composition include known toothbrushes. A typical commercially available toothbrush can be used with the oral composition.

[0068] (Manufacturing Method) In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other appropriate ingredients. To obtain an oral composition having (PF3)*(TF5) and TF10 within specific ranges, it is important to appropriately select the ingredients and blending ratios contained in the oral composition and to appropriately select the manufacturing process for the oral composition. For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the blend. A combination of abrasive silica and an inorganic binder is preferred, and a combination of abrasive silica and a thickening silica is even more preferred. It is also preferable to further blend an organic binder into the oral composition. It is also preferable to further blend a humectant into the oral composition. It is also preferable to perform the manufacturing process for the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add the thickening silica, abrasives, and other appropriate ingredients during or after mixing the humectant, organic binder, and water, and then stir and mix until uniform. It is also preferable to prepare a mixture of a part of the wetting agent and the organic binder in advance, add the mixture at the stage where the mixture has become homogeneous, and stir until the mixture is homogeneous. Furthermore, it is more preferable to carry out these steps under vacuum.

[0069] (Dentifrice) In this embodiment, the dentifrice is the oral composition filled in a tube container, preferably a toothpaste composition filled in a tube container. In this embodiment, the oral composition has an excellent balance between the ease of squeezing it out of the tube container and the cushioning effect during tooth brushing, so by filling this into a tube container to make a dentifrice, it is possible to improve the ease of squeezing it out of the tube container. Furthermore, the squeezed dentifrice can provide a desirable cushioning effect in the oral cavity.

[0070] Furthermore, oral compositions such as toothpaste compositions are preferably used by squeezing them out of a tube container. Known containers can be used as the tube container. The material of the tube container can be, for example, one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, and nylon; and metal materials such as aluminum. For example, the tube container may be a single-layer or multi-layer container made of these materials. The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum-laminated tube container may be used in which the innermost layer of the container is made of polyethylene and further comprises an aluminum layer.

[0071] The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and even more preferably 3 mm or more. This allows for more stable reduction of the excessive force required to discharge the oral composition. The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and even more preferably 9 mm or less. This allows for efficient suppression of dripping. The length of the tube container excluding the discharge port may be approximately 50 to 160 mm, and the outer circumferential length of the tube container in the width direction may be approximately 20 to 120 mm.

[0072] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various other configurations can also be adopted.

[0073] The present embodiment will be specifically described below with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0074] (Examples 1 to 15, Comparative Examples 1 to 3) In these examples, oral compositions that are toothpaste compositions were prepared and evaluated. The formulations, measurements, and evaluation results for each example are shown in Tables 1 to 3. The formulations of each component in these tables are in mass %, and the particle size of silica is the average particle size. Details of the components listed in Tables 1 to 3 are also shown below. Sorbitol Kao: 70% sorbitol liquid, manufactured by Kao Corporation Cosmetic concentrated glycerin: concentrated glycerin, manufactured by Sakamoto Pharmaceutical Industry Co., Ltd. Sodium alginate SHG: sodium alginate, manufactured by Maikon no Kohara Co., Ltd. NIKKOL SLS: sodium lauryl sulfate, manufactured by Nikko Chemicals Co., Ltd. Caustic soda (48%): aqueous sodium hydroxide solution, manufactured by Tatsumi Synthetic Chemical Co., Ltd.

[0075] (Preparation of Oral Composition) Sorbitol or glycerin and purified water were weighed into a beaker, and an organic binder was gradually added while stirring at 2,500 rpm at 80° C. using an emulsifying / dispersing device (Labo-Lusion, manufactured by Primix Corporation) and a stirring section (Homodisper 2.5 type, manufactured by Primix Corporation). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL / g), sodium lauryl sulfate, and caustic soda were added in that order, stirring and mixing with a rubber spatula each time until the mixture was uniform.

[0076] (Rheometer Push-Up Test) PF3 was measured at 25°C by the above-mentioned Method 1. Device name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure-sensitive shaft for pressure / elasticity measurement (Φ20 mm) Measurement speed: 60 mm / min Push-up distance: 3 mm Filling container: 30 mL plastic jar (diameter 43 mm) The maximum value of stress during pushing was measured three times, and the average value was calculated.

[0077] (Rheometer pull test) TF5 and TF10 were measured at 25°C using Method 2 described above. Device name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd., detection limit: 0.1 gf) Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm or 10 mm Filling container: 30 mL plastic jar (diameter 43 mm) The stress at each pull-up distance was measured three times, and the average value was calculated. Although the measured values ​​are negative, absolute values ​​(positive values) were used to compare the magnitude of the force.

[0078] (Evaluation Method) (Ease of Squeezing) The toothpaste composition of each example was evaluated for ease of squeezing when squeezed out of the tube container according to the following criteria, with A to C being considered acceptable. The tube container used was a laminated tube made of low-density polyethylene (LDPE) with an opening diameter of 19 mm and a size of 40Φ x 130H (40Φ One-Touch Tube-124.6, manufactured by Takemoto Container Co., Ltd.). The cap used was a one-touch cap made of polypropylene with an opening diameter of 6 mm and a size of 39Φ x 24H (T-40Φ One-Touch CAP II, manufactured by Takemoto Container Co., Ltd.). This was placed on a horizontal surface at room temperature (25°C), and one evaluator slowly pressed the centre of the tube container with the pads of their index and middle fingers to dispense the composition and evaluate the ease of squeezing. A: Moderately firm and easy to squeeze B: Slightly loose, but no problems with usability C: Loose, tends to drip from the mouth, but usable D: Hard and difficult to squeeze

[0079] (Cushioning properties) The toothpaste composition of each example was filled into the tube container used to evaluate ease of squeezing. A 1.5 cm length of the toothpaste composition of each example was placed on a toothbrush (manufactured by Lion Corporation) with a head size of 18 mm and bristles made of saturated polyester resin, and three evaluators applied it to the entire teeth. When applying, the softness of the toothbrush on the gums and tooth surface was evaluated by consensus according to the following criteria, with A to C being considered acceptable. A: Feels soft to the touch B: Feels slightly soft to the touch C: Feels a slight change in the touch D: Does not feel soft to the touch at all

[0080]

[0081]

[0082]

[0083] This application claims priority based on Japanese Patent Application No. 2024-116014, filed July 19, 2024, the disclosure of which is incorporated herein in its entirety by reference.

Claims

1. An oral composition comprising an abrasive and a binder, wherein, when PF3 is the maximum pushing stress in a 3 mm indentation test measured by Method 1 below, and TF5 and TF10 are the tensile stresses in a 5 mm tensile test and a 10 mm tensile test measured by Method 2 below, respectively, (PF3) * (TF5) is 50 (gf)^2 or more and less than 5000 (gf)^2, and TF10 is 4.0 gf or more and 50 gf or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20 mm) Measurement speed: 60 mm / min Push-in distance: 3 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The oral composition is filled to the top and set in the device, and then pushed to the push-in distance at the measurement speed and the maximum stress during pushing is measured. The average value of three measurements is designated as PF3. (Method 2) Name of device: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm or 10 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pulled up at the measurement speed, and the absolute value of the stress at each pull-up distance is measured. The average value of three measurements at each pull-up distance is designated as TF5 or TF10.

2. The oral composition of claim 1, wherein the binder comprises a thickening silica.

3. The oral composition of claim 1 or 2, wherein the binder comprises an organic binder.

4. The oral composition according to claim 3, wherein the organic binder is one or more selected from the group consisting of carboxymethyl cellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).

5. An oral composition according to any one of claims 1 to 4, wherein the abrasive comprises abrasive silica.

6. An oral composition according to any one of claims 1 to 5, further comprising a humectant.

7. An oral composition according to any one of claims 1 to 6, which is a dentifrice composition.

8. An oral composition according to any one of claims 1 to 7, which is a toothpaste composition.

9. A dentifrice comprising the oral composition according to any one of claims 1 to 8 packed in a tube container.

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