Composition for oral cavity

Abstract

Provided is composition for the oral cavity containing a polishing agent and a binder, in which the tensile return force TF5 in a 5 mm tension test measured using a rheometer is 10 gf or more and 50 gf or less, the spinnability measured using the rheometer is 24 mm or more and 50 mm or less, and the viscosity measured using a B type viscometer is 100 Pa·s or less.

Description

Oral composition

[0001] The present invention relates to an oral composition.

[0002] Patent Document 1 (JP 2021-91654 A) describes a technology for improving the ease of application of oral compositions to toothbrushes. This document describes a dentifrice composition containing one or more water-soluble polyvalent metal salts selected from water-soluble aluminum salts, water-soluble copper salts, and water-soluble zinc salts, xanthan gum, and a cationic polymer compound (Claim 1). According to this document, a dentifrice composition can be provided that exhibits the effects of the water-soluble polyvalent metal salt, such as suppressing hypersensitivity, suppressing bad breath, and tightening the gums, while also exhibiting excellent moldability, making it easy to apply to a toothbrush, and exhibiting reduced hardening over time and excellent removability from the container after storage. This dentifrice composition maintains satisfactory physical properties, and can also be formulated into a dentifrice composition with a relatively low or no abrasive content, ensuring a gentle, low-irritation brushing experience. It is particularly useful for suppressing hypersensitivity or bad breath and tightening the gums (paragraph 0011).

[0003] Japanese Patent Application Laid-Open No. 2021-91654

[0004] Through investigations by the present inventors, it has become clear that there is still room for improvement in the composition described in Patent Document 1 above, in terms of improving usability when squeezing the composition filled in the tube container from the tube container, specifically in terms of making it easier to squeeze and cut cleanly.

[0005] The present invention provides an oral composition that has an excellent balance between ease of squeezing when squeezed out of a tube container and sharpness of the mouthfeel.

[0006] According to the present invention, the following oral composition is provided. [1] An oral composition comprising an abrasive and a binder, wherein the tensile return force TF5 in a 5 mm tensile test, as measured by Method 1 below, is 10 gf or more and 50 gf or less, the stringiness, as measured by Method 2 below, is 24 mm or more and 50 mm or less, and the viscosity, as measured by Method 3 below, is 100 Pa s or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The oral composition is filled to the brim, set in the device, and then pulled up at the measurement speed. The absolute value of the stress at the time when the pull-up distance is reached is measured. The average of three measurements is taken as the TF5. (Method 2) Device name: Rheometer Jig used: Pressure-sensitive shaft for measuring penetration degree (Φ15 mm) Measurement speed: 1000 mm / min Pull-up distance: 50 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pulled up at the measurement speed. During pulling, the distance until the oral composition separates from the jig used is measured. The average value of three measurements up to the pull-up distance is taken as the spinnability. (Method 3) Device name: Brookfield type viscometer, rotor No. 4 Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, the viscosity is measured at the measurement speed and for the measurement time. [2] The oral composition according to [1], wherein the binder comprises thickening silica. [3] The oral composition according to [1] or [2], wherein the binder comprises an organic binder. [4] The organic binder is selected from the group consisting of carboxymethyl cellulose and salts thereof, xanthan gum, alginic acid and salts thereof, polyacrylic acid and salts thereof, carboxyvinyl polymers, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).[5] The oral composition according to any one of [1] to [4], wherein the abrasive comprises abrasive silica. [6] The oral composition according to any one of [1] to [5], further comprising a humectant. [7] The oral composition according to any one of [1] to [6], which is a dentifrice composition. [8] The oral composition according to any one of [1] to [7], which is a toothpaste composition. [9] A dentifrice in which the oral composition according to any one of [1] to [8] is filled in a tube container.

[0007] Any combination of these configurations and conversion of the present invention between methods, devices, etc. are also valid aspects of the present invention.

[0008] According to the present invention, an oral composition can be obtained that has an excellent balance between ease of squeezing when squeezed out of a tube container and sharpness of the mouthfeel.

[0009] Hereinafter, an embodiment of the present invention will be described. In this embodiment, the composition may contain each component alone or in combination of two or more. In this specification, the term "to" indicating a numerical range means "at least" or "at most," and both end values ​​are included.

[0010] (Oral Composition) In this embodiment, the oral composition contains an abrasive and a binder. The tensile return force TF5 in a 5 mm tensile test, measured by Method 1 below, is 10 gf or more and 50 gf or less; the stringiness, measured by Method 2 below, is 24 mm or more and 50 mm or less; and the viscosity, measured by Method 3 below, is 100 Pa·s or less. (Method 1) Device name: Rheometer (e.g., CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure-sensitive shaft for pressure / elasticity measurement (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to the brim with the oral composition, set in the device, and then pulled up at the measurement speed. The absolute value of the stress at the point where the pull-up distance is reached is measured. The average value of three measurements is taken as TF5. In the procedure of Method 1, the numerical value of the stress during pulling is a negative value, so the recorded value is a negative value and the absolute value is a positive value.

[0011] (Method 2) Name of device: Rheometer (for example, CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure-sensitive shaft for measuring penetration degree (Φ15 mm) Measurement speed: 1000 mm / min Pull-up distance: 50 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: Fill the filling container to the top with the oral composition, set it in the device, and then pull it up at the measurement speed. Measure the distance until the oral composition separates from the jig used during pulling. Measure the pull-up distance three times, and the average value is taken as the stringiness.

[0012] (Method 3) Name of instrument: Brookfield viscometer, rotor No. 4 (for example, TVB-25L manufactured by Toki Sangyo Co., Ltd.) Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the instrument, the viscosity is measured at the above-mentioned measurement speed and measurement time.

[0013] Here, the measurement temperature in Measurements 1 to 3 is specifically room temperature (25° C.).

[0014] The present inventors conducted research focusing on the ingredients and physical properties of oral compositions filled in a tube container as design guidelines for improving usability when the composition is squeezed from the tube. As a result, they discovered that by controlling the ingredients of the oral composition while using the tensile return force TF5, spinnability, and viscosity as indicators, the oral composition filled in the tube container can be easily squeezed from the tube container and has excellent sharpness, with a favorable balance of these. That is, in this embodiment, the oral composition contains a combination of an abrasive and a binder, and the tensile return force TF5, spinnability, and viscosity are each within a specific range, resulting in an excellent balance between ease of squeezing and sharpness when squeezed from the tube container. This also makes it possible to provide an oral composition that is easy to handle. For example, it is possible to reduce the feeling of excessive hardness when squeezing the oral composition filled in the tube container from the tube container and to favorably reduce dripping from the discharge spout. It is also possible to improve the ease of handling of the oral composition in the process from squeezing the dentifrice filled in a tube container onto a toothbrush to applying it to the oral cavity.

[0015] The tensile return force TF5 in a 5 mm tensile test measured by Method 1 is 10 gf or more, preferably 10.5 gf or more, more preferably 11 gf or more, and even more preferably 11.5 gf or more. This makes it possible to obtain an oral composition that is less likely to drip when dispensed onto a toothbrush. This also improves the sharpness of the oral composition when squeezed out of the tube container. From the same perspective, TF5 is 50 gf or less, preferably 40 gf or less, more preferably 30 gf or less, even more preferably 20 gf or less, and even more preferably 18 gf or less. This also makes it possible to obtain an oral composition that easily separates from the tube container when squeezed out.

[0016] The stringiness of the oral composition measured by Method 2 is 24 mm or more, preferably 27 mm or more, and more preferably 30 mm or more. This allows for an oral composition that is easy to spread in the oral cavity. Furthermore, the stringiness of the oral composition is 50 mm or less, preferably 45 mm or less, and more preferably 40 mm or less. This allows for an oral composition that is less likely to feel unpleasantly sticky when brushing teeth.

[0017] The viscosity of the oral composition measured by Method 3 is 100 Pa s or less, preferably 90 Pa s or less, more preferably 80 Pa s or less, even more preferably 70 Pa s or less, and even more preferably 60 Pa s or less. This makes it possible to obtain an oral composition that is easy to handle when filled into a tube container. Furthermore, the viscosity of the oral composition is specifically 0 Pa s or more, preferably 10 Pa s or more, and more preferably 20 Pa s or more. This makes it possible to obtain an oral composition that firmly adheres to and remains on the tooth surface during brushing.

[0018] Next, the components of the oral composition will be described. As described above, the oral composition contains an abrasive and a binder.

[0019] (Abrasive) Examples of the abrasive include one or more selected from the group consisting of abrasive silica such as hydrous silicic acid (e.g., gel silica, precipitated silica), anhydrous silicic acid, silica gel, and aluminosilicate; zeolite; calcium phosphate-based abrasives such as calcium hydrogen phosphate anhydrate, calcium hydrogen phosphate dihydrate, and calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; and other inorganic abrasives such as aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, and quaternary calcium phosphate; and organic abrasives such as synthetic resin-based abrasives.

[0020] The abrasive preferably contains abrasive silica, more preferably hydrated silicic acid. It is also preferable to contain anhydrous silicic acid. This allows for a more stable improvement in the balance between ease of squeezing and sharpness when squeezing from a tube container. The abrasive silica may be either crystalline silica or amorphous silica, or may be wet silica.

[0021] The average particle size of the abrasive silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 3 μm or more, and even more preferably 5 μm or more. This allows for efficient removal of stains from the tooth surface. The average particle size of the abrasive silica is also preferably 50 μm or less, more preferably 30 μm or less, and even more preferably 20 μm or less. This allows for a smooth mouthfeel to be obtained in an oral composition.

[0022] Here, the average particle size of the abrasive silica and the thickening silica described below is determined by measuring the particle size distribution of the particles on a volume basis using a commercially available laser diffraction / scattering particle size distribution measuring device. 50 It can be said that:

[0023] It is also preferable that the abrasive is substantially free of calcium carbonate. This allows for a more stable improvement in the balance between ease of squeezing the composition out of the tube and sharpness of the resultant cleansing. Here, "the oral composition is free of calcium carbonate" specifically means that calcium carbonate is not intentionally blended into the oral composition, and more specifically means that the calcium carbonate content is 0.001% by mass or less of the total oral composition.

[0024] The content of the abrasive in the oral composition is preferably 5% by mass or more, more preferably more than 5% by mass, even more preferably 10% by mass or more, even more preferably more than 10% by mass, even more preferably 11% by mass or more, and even more preferably 13% by mass or more, based on the total oral composition. This allows for efficient removal of stains from the tooth surface. Furthermore, the content of the abrasive in the oral composition is preferably 30% by mass or less, more preferably less than 30% by mass, even more preferably 25% by mass or less, and even more preferably 20% by mass or less, based on the total oral composition. This allows for an oral composition with excellent smoothness in use.

[0025] (Binder) Examples of the binder include at least one selected from the group consisting of thickening silica such as hydrous silicic acid (e.g., gel silica, precipitated silica) and anhydrous silicic acid (e.g., gel silica, precipitated silica, and dry silica); other inorganic binders such as bentonite; and organic binders such as pullulan, gelatin, methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, carrageenan, alginic acid and salts thereof, xanthan gum, polyacrylic acid and salts thereof, gum arabic, guar gum, locust bean gum, polyvinyl alcohol, and carboxyvinyl polymers. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0026] The binder preferably contains an inorganic binder, more preferably contains thickening silica, which makes it possible to more stably improve the balance between ease of squeezing when squeezing the composition from the tube container and sharpness of the composition.

[0027] The thickening silica may be either crystalline silica or amorphous silica, and may be either dry silica or wet silica.The average particle size of the thickening silica is preferably 1 μm or more, more preferably 2 μm or more, even more preferably 5 μm or more, and even more preferably 10 μm or more.This allows the viscosity of the oral composition to be more efficiently maintained.In addition, the average particle size of the thickening silica is preferably 60 μm or less, more preferably 50 μm or less, and even more preferably 40 μm or less.This allows the oral composition to have a smooth texture in the mouth.

[0028] The oil absorption of the thickening silica, as determined by the amount of boiled linseed oil absorbed according to the method described in JIS K 5101-13-2 (2004), is, for example, 0.1 mL / g or more, preferably 0.2 mL / g or more, and, for example, 5 mL / g or less, preferably 4 mL / g or less.

[0029] The content of inorganic binder in the oral composition is preferably 2% by mass or more, more preferably 2.5% by mass or more, even more preferably 3% by mass or more, and even more preferably 4% by mass or more, based on the total oral composition. This allows for an oral composition with excellent cushioning properties when brushing teeth. This also reduces irritation caused by contact of the toothbrush with the teeth, gums, etc. Furthermore, the content of inorganic binder in the oral composition is preferably 30% by mass or less, more preferably 25% by mass or less, even more preferably 20% by mass or less, and even more preferably 15% by mass or less, based on the total oral composition. This allows for an oral composition with excellent surface smoothness.

[0030] The binder preferably contains an organic binder. When the binder contains thickening silica, it is preferable that the binder further contains an organic binder. This makes it possible to more stably improve the balance between ease of squeezing when squeezing from the tube container and sharpness of the product.

[0031] In view of the above, the organic binder preferably comprises one or more selected from the group consisting of carboxymethylcellulose and its salts (e.g., sodium carboxymethylcellulose), xanthan gum, alginic acid and its salts (e.g., sodium alginate), polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (preferably excluding κ-carrageenan, e.g., ι-carrageenan); more preferably, it comprises one or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; even more preferably, it comprises two or more selected from the group consisting of carrageenan, sodium alginate, sodium carboxymethylcellulose, and xanthan gum; still more preferably, it comprises sodium alginate or sodium carboxymethylcellulose and xanthan gum; and even more preferably, it comprises sodium alginate and xanthan gum. Specific examples of the salts include alkali metal salts such as sodium salts and potassium salts.

[0032] On the other hand, in terms of facilitating rinsing the oral cavity, it is also preferable that the oral composition does not contain xanthan gum. Specifically, the oral composition not containing xanthan gum means that xanthan gum is not intentionally blended into the oral composition, and more specifically, the content of xanthan gum is 0.001% by mass or less of the entire oral composition.

[0033] The content of the organic binder in the oral composition is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, and even more preferably 1% by mass or more, based on the total oral composition. This allows the oral composition to have an appropriate viscosity. Furthermore, the content of the organic binder in the oral composition is preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows the oral composition to be squeezed out smoothly from the tube container.

[0034] The mass ratio of the organic binder content to the inorganic binder content in the oral composition (organic binder / inorganic binder) is preferably 0.05 or more, more preferably 0.1 or more, and even more preferably 0.2 or more. This makes it possible to obtain an oral composition that is smooth to the touch and has an excellent usability. Furthermore, the mass ratio (organic binder / inorganic binder) is preferably 2.0 or less, more preferably 1.75 or less, even more preferably 1.5 or less, even more preferably 1.25 or less, and even more preferably 0.9 or less. This makes it possible to obtain an oral composition that is excellent in sharpness when dispensed from a tube container onto a toothbrush or the like.

[0035] The total content of binders in the oral composition is preferably 2% by mass or more, more preferably 3% by mass or more, and even more preferably 5% by mass or more, based on the total oral composition. This allows the oral composition to have an appropriate viscosity. Furthermore, the total content of binders in the oral composition is, for example, 45% by mass or less, preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 11% by mass or less, and even more preferably 10% by mass or less, based on the total oral composition. This allows the oral composition to be more easily absorbed by saliva during tooth brushing. Furthermore, excessive thickening of the oral composition can be suppressed.

[0036] The total content of silica in the oral composition is preferably 10% by mass or more, more preferably 15% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition. This allows the fluidity of the oral composition to be moderately suppressed. The total content of silica in the oral composition is, for example, 60% by mass or less, preferably 30% by mass or less, more preferably 27.5% by mass or less, and even more preferably 25% by mass or less, based on the total oral composition. This allows for an oral composition that is more easily mixed with saliva in the oral cavity, for example, during tooth brushing.

[0037] (Other Components) The oral composition may further contain components other than those described above. Such components include medicinal ingredients, thickeners, surfactants, humectants, flavoring agents, preservatives, fragrances, colorants, pH adjusters, solvents, solubilizers, bases, detergents, adsorbents, etc., and may be selected appropriately depending on the dosage form.

[0038] Examples of medicinal ingredients include one or more selected from the group consisting of bactericides, anti-inflammatory agents, blood circulation promoters, tartar inhibitors, stain removers, anti-hypersensitivity agents, vitamins, and plaque-decomposing enzymes. These medicinal ingredients are not limited as long as they can be used in pharmaceuticals, etc.

[0039] Among the medicinal ingredients, examples of disinfectants include one or more selected from the group consisting of isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, hinokitiol, chlorhexidine hydrochloride, alkyldiaminoethylglycine hydrochloride, sodium lauroyl sarcosine, and triclosan.

[0040] Examples of anti-inflammatory agents include one or more selected from the group consisting of tranexamic acid, β-glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinic acid, diammonium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, stearyl glycyrrhetinate, ε-aminocaproic acid, sodium azulene sulfonate hydrate, allantoin, allantoin dihydroxyaluminum, epidihydrocholesterol, dihydrocholesterol, and lysozyme hydrochloride.

[0041] Examples of the blood circulation promoter include one or more selected from the group consisting of sodium chloride, tocopherol acetate, sodium bicarbonate, sodium hydrogen carbonate, and tocopherol nicotinate.

[0042] Examples of tartar deposit inhibitors include one or more selected from the group consisting of disodium hydrogen phosphate, disodium dihydrogen pyrophosphate, sodium pyrophosphate, anhydrous sodium pyrophosphate, tetrasodium pyrophosphate (anhydrous), disodium monohydrogen phosphate, sodium hydrogen phosphate hydrate, disodium hydrogen phosphate (crystalline), trisodium phosphate, and sodium polyphosphate.

[0043] Examples of stain removers include one or more selected from the group consisting of macrogol (Macrogol 200, Macrogol 300, Macrogol 400, Macrogol 600, Macrogol 1000, Macrogol 1500, Macrogol 1540, Macrogol 4000, Macrogol 6000, Macrogol 20000, etc.), sodium polyphosphate, and polyvinylpyrrolidone.

[0044] The dentin hypersensitivity reducing agent may be, for example, at least one selected from the group consisting of potassium nitrate and water-soluble aluminum salts.

[0045] Examples of vitamin preparations include one or more selected from the group consisting of vitamin C and derivatives thereof, such as ascorbic acid, L-ascorbic acid, sodium ascorbate, sodium L-ascorbate, magnesium L-ascorbyl phosphate, pyridoxine hydrochloride, L-ascorbic acid 2-glucoside, ascorbyl tetra-2-hexyldecanoate, trisodium ascorbyl palmitate phosphate, 3-O-ethyl ascorbic acid, tocopherol, disodium isostearyl ascorbyl phosphate, and caprylyl 2-glyceryl ascorbate; and vitamin E and derivatives thereof, such as DL-α-tocopherol acetate, tocopherol acetate, dl-α-tocopherol nicotinate, and tocopherol nicotinate.

[0046] An example of a plaque decomposing enzyme is dextranase.

[0047] The thickening agent may be, for example, a commercially available thickening agent used as a raw material for pharmaceuticals, foods, or cosmetics. The thickening agent may include, for example, one or more selected from the group consisting of polyhydric alcohols, more specifically, sorbitol (sorbite), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, xylitol, maltite, lactite, trehalose, sodium hyaluronate, and hydrolyzed collagen.

[0048] Examples of surfactants include anionic surfactants such as N-acylamino acid salts, α-olefin sulfonates, N-acylsulfonates, alkyl sulfates (e.g., sodium lauryl sulfate), and sulfates of glycerin fatty acid esters; nonionic surfactants such as polyoxyethylene alkyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene hydrogenated castor oil, polyoxyethylene ethers of glycerin esters, sucrose fatty acid esters, alkylolamides, and glycerin fatty acid esters; and amphoteric surfactants such as alkyl betaine surfactants (e.g., coconut oil fatty acid amido alkyl betaine), amine oxide surfactants, and imidazolinium betaine surfactants (e.g., 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine). The surfactant may also be a foaming agent.

[0049] The content of the surfactant in the oral composition is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and even more preferably 1% by mass or more, based on the total oral composition. This allows for an oral composition that foams appropriately when brushing teeth. Furthermore, the content of the surfactant in the oral composition is preferably 5% by mass or less, more preferably 3% by mass or less, and even more preferably 2% by mass or less, based on the total oral composition. This allows for an oral composition with cleansing power that does not excessively remove oil from the oral cavity.

[0050] The oral composition preferably further contains a humectant, which can improve the production stability of the oral composition. The humectant may be any humectant that is commercially available as a pharmaceutical, food, or cosmetic ingredient, such as a polyhydric alcohol, and more specifically, one or more selected from the group consisting of sorbitol (sorbitol), glycerin, concentrated glycerin, diglycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, propanediol (1,3-propanediol), polyethylene glycol, polypropylene glycol, sodium hyaluronate, and hydrolyzed collagen.

[0051] In terms of reducing irritation to the oral cavity, the humectant is preferably at least one selected from the group consisting of sorbitol, concentrated glycerin, and propylene glycol, more preferably sorbitol or concentrated glycerin.

[0052] The content of the humectant in the oral composition is preferably 5% by mass or more, more preferably 10% by mass or more, and even more preferably 20% by mass or more, based on the total oral composition. This allows for an oral composition with excellent moisturizing ability in the oral cavity. Furthermore, the content of the humectant in the oral composition is preferably 50% by mass or less, more preferably 45% by mass or less, and even more preferably 40% by mass or less, based on the total oral composition. This allows for an oral composition that is easy to rinse off with gargle.

[0053] Examples of flavoring agents include one or more selected from the group consisting of sodium L-glutamate, saccharin, saccharin sodium, sucrose, glucose, fructose, lactose, honey, aspartame, stevia, sucralose, inositol, D-sorbitol, D-mannitol, arabitol, raffinose, lactulose, lactitol, xylitol, erythritol, reduced palatinose, palatinose, Palatinit (registered trademark), acesulfame K, trehalose, maltose, maltosyltrehalose, or maltitol, neohesperidin dihydrochalcone, perillartine, p-methoxycinnamic aldehyde, and thaumatin.

[0054] The flavoring agent is preferably at least one selected from the group consisting of xylitol, saccharin sodium, and saccharin, and more preferably at least one selected from the group consisting of xylitol and saccharin sodium, since it has a strong sweetness and can adjust the taste even with a small amount.

[0055] Examples of preservatives include one or more selected from the group consisting of paraoxybenzoic acid esters such as sodium benzoate, methylparaben, ethylparaben, butylparaben, isopropylparaben, propylparaben, isobutylparaben, and benzylparaben; alcohols such as phenoxyethanol; sorbic acid, benzoic acid, dehydroacetic acid, propionic acid, and salts thereof; ethylenediaminetetraacetate, alkyldiaminoethylglycine hydrochloride, and ethylhexylglycerin. Specific examples of the above salts include alkali metal salts such as sodium salts and potassium salts; and alkaline earth metal salts such as calcium salts and magnesium salts.

[0056] The flavoring agent may be, for example, one or more selected from the group consisting of L-menthol, peppermint, spearmint, fruit flavorings, and peppermint oil.

[0057] Examples of coloring agents include one or more selected from the group consisting of natural dyes such as safflower red dye, gardenia yellow dye, gardenia blue dye, perilla dye, red koji dye, red cabbage dye, carrot dye, hibiscus dye, cacao dye, spirulina blue dye, and coumarind dye; legally mandated dyes such as Red No. 3, Red No. 104, Red No. 105, Red No. 106, Yellow No. 4, Yellow No. 5, Green No. 3, and Blue No. 1; riboflavin, and titanium dioxide.

[0058] Examples of pH adjusters include one or more selected from the group consisting of acids and alkalis, such as acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, succinic acid, glutamic acid, pyrophosphoric acid, tartaric acid, acetic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, sodium hydrogen citrate, phosphoric acid, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, and potassium dihydrogen phosphate, and buffering agents.

[0059] The solvent may be water, or a lower alcohol such as ethanol, propanol, etc. The solvent may be a liquid base.

[0060] The content of water in the oral composition can be, for example, the remainder after excluding components other than water from the oral composition. The content of water in the oral composition can be, for example, 30 to 80% by mass, and preferably 32 to 70% by mass, based on the total oral composition. It is also preferable that the oral composition does not contain ethanol, i.e., the ethanol content is 0% by mass, or that the oral composition contains ethanol but the ethanol content is 5% by mass or less. This can suppress strong irritation to the oral cavity.

[0061] A solubilizer may be added to promote the dissolution of the additives and medicinal ingredients in water. Examples of such solubilizers include polyhydric alcohols such as dipropylene glycol.

[0062] Other bases include, for example, sodium bicarbonate.

[0063] Detergents include, for example, sodium polyphosphate.

[0064] The adsorbent may be, for example, β-cyclodextrin.

[0065] Furthermore, in addition to the above components, components generally suitable for use in oral compositions can also be appropriately blended within the scope of the present invention.

[0066] (Dosage form, etc.) Specific examples of oral compositions include dentifrices such as toothpaste. The oral composition is preferably a dentifrice composition, more preferably a toothpaste composition. This can further improve the ease of handling of the oral composition. From the same point of view, the oral composition is preferably in the form of a paste or gel.

[0067] The oral composition is preferably applied to the oral cavity by being placed on a toothbrush. Examples of toothbrushes that can be used with the oral composition include known toothbrushes. A typical commercially available toothbrush can be used with the oral composition.

[0068] (Manufacturing Method) In this embodiment, the oral composition includes a step of blending, for example, an abrasive, a binder, and other appropriate ingredients. To obtain an oral composition having a TF5, spinnability, and viscosity within a specific range, it is important to appropriately select the ingredients and blending ratios contained in the oral composition and to appropriately select the manufacturing process for the oral composition. For example, it is important to appropriately select and combine the types and amounts of abrasives and binders contained in the oral composition to design the blend. A combination of abrasive silica and an inorganic binder is preferred, and a combination of abrasive silica and a thickening silica is even more preferred. It is also preferable to further blend an organic binder into the oral composition. It is also preferable to further blend a humectant into the oral composition. It is also preferable to perform the manufacturing process for the oral composition under vacuum. For example, when the oral composition contains thickening silica, an organic binder, a humectant, and water, it is preferable to add the thickening silica, abrasives, and other appropriate ingredients during or after mixing the humectant, organic binder, and water, and then stir and mix until uniform. It is also preferable to prepare a mixture of a part of the wetting agent and the organic binder in advance, add the mixture at the stage where the mixture has become homogeneous, and stir until the mixture is homogeneous. Furthermore, it is more preferable to carry out these steps under vacuum.

[0069] (Dentifrice) In the present embodiment, the dentifrice is the above-mentioned oral composition filled in a tube container, preferably a toothpaste composition filled in a tube container. In this embodiment, the oral composition has an excellent balance between ease of squeezing and sharpness when squeezed out of the tube container, so by filling this into a tube container to make a dentifrice, it is possible to make the dentifrice easy to handle when squeezing it from the tube container onto a toothbrush and applying it to the oral cavity.

[0070] Furthermore, oral compositions such as toothpaste compositions are preferably used by squeezing them out of a tube container. Known containers can be used as the tube container. The material of the tube container can be, for example, one or more selected from the group consisting of resin materials such as polyethylene, polypropylene, polyethylene terephthalate, and nylon; and metal materials such as aluminum. For example, the tube container may be a single-layer or multi-layer container made of these materials. The material of the innermost layer of the container is preferably one or more selected from the group consisting of polyethylene, polypropylene, and polyethylene terephthalate. For example, an aluminum-laminated tube container may be used in which the innermost layer of the container is made of polyethylene and further comprises an aluminum layer.

[0071] The inner diameter of the discharge port of the tube container is preferably 1 mm or more, more preferably 2 mm or more, and even more preferably 3 mm or more. This allows for more stable reduction of the excessive force required to discharge the oral composition. The inner diameter of the discharge port of the tube container is preferably 11 mm or less, more preferably 10 mm or less, and even more preferably 9 mm or less. This allows for efficient suppression of dripping. The length of the tube container excluding the discharge port may be approximately 50 to 160 mm, and the outer circumferential length of the tube container in the width direction may be approximately 20 to 120 mm.

[0072] Although the embodiments of the present invention have been described above, these are merely examples of the present invention, and various other configurations can also be adopted.

[0073] Hereinafter, the present embodiment will be specifically described with reference to examples and comparative examples, but the present embodiment is not limited to these examples.

[0074] (Examples 1 to 3, Comparative Examples 1 to 3) In these examples, oral compositions that are toothpaste compositions were prepared and evaluated. The formulations, measurements, and evaluation results for each example are shown in Table 1. The unit of component amounts in Table 1 is mass %, and the particle size of silica is the average particle size. Details of the components listed in Table 1 are also shown below. Sorbitol Kao: 70% sorbitol liquid, manufactured by Kao Corporation Cosmetic concentrated glycerin: concentrated glycerin, manufactured by Sakamoto Pharmaceutical Industry Co., Ltd. CEKOL 30000: CMC-Na, manufactured by CP KELCO Sodium alginate SHG: sodium alginate, manufactured by Maikon no Kohara Co., Ltd. NIKKOL SLS: sodium lauryl sulfate, manufactured by Nikko Chemicals Co., Ltd. Caustic soda (48%): sodium hydroxide aqueous solution, manufactured by Tatsumi Synthetic Chemical Co., Ltd.

[0075] (Preparation of Oral Composition) Sorbitol or glycerin and purified water were weighed into a beaker, and an organic binder was gradually added while stirring at 2,500 rpm at 80° C. using an emulsifying / dispersing device (Labo-Lusion, manufactured by Primix Corporation) and a stirring section (Homodisper 2.5 type, manufactured by Primix Corporation). After stirring and mixing for 3 minutes, abrasive silica, thickening silica (oil absorption 2.5 mL / g), sodium lauryl sulfate, and caustic soda were added in that order, stirring and mixing with a rubber spatula each time until the mixture was uniform.

[0076] (Tensile return force) TF5 was measured at 25°C using the method described in Method 1 above. Instrument name: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd., detection limit: 0.1 gf) Jig used: Pressure / elasticity measurement pressure-sensitive shaft (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm or 10 mm Filling container: 30 mL plastic jar (diameter 43 mm) The absolute value of the stress at the time when the pull-up distance was reached was measured three times at the pull-up distance, and the average value was calculated and used as TF5. Although the measured value is a negative value, the absolute value (positive value) was used to compare the magnitude of the force.

[0077] (Spinability) Spinnability was measured at 25°C according to Method 2 described above. Name of device: Rheometer (CR-3000EX-S, manufactured by Sun Scientific Co., Ltd.) Jig used: Pressure-sensitive shaft for measuring penetration degree (Φ15 mm) Measurement speed: 1000 mm / min Pulling-up distance: 50 mm Filling container: 30 mL plastic jar (diameter 43 mm) The distance until the toothpaste composition separated from the jig used during pulling-up was measured three times, and the average value was calculated.

[0078] (Viscosity) Measurement was carried out at 25°C according to the method 3 described above. Name of instrument: Brookfield viscometer, rotor No. 4 (TVB-25L, manufactured by Toki Sangyo Co., Ltd.) Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm) Procedure: The filling container was filled to the top with the toothpaste composition, and after setting it in the instrument, the viscosity was measured at the measurement speed and for the measurement time described above.

[0079] (Evaluation Method) (Ease of Squeezing) The ease of squeezing each toothpaste composition from a tube container was evaluated by the following method. Each toothpaste composition was filled into a laminate tube (manufactured by Takemoto Container Co., Ltd.) made of low-density polyethylene (LDPE) and having an opening diameter of 19 mm and a size of 40Φ x 130H. A one-touch cap (T-40Φ One-Touch CAP II, manufactured by Takemoto Container Co., Ltd.) made of polypropylene and having an opening diameter of 6 mm and a size of 39Φ x 24H was attached as a cap. This was placed on a balance (MSU6202S-100-D0, manufactured by Sartorius) at room temperature (25°C), and the magnitude of force (g) required to press the center of the tube container 1 cm in approximately 1 second with the pads of the index and middle fingers to dispense the composition was measured. A force of 500 g or more and less than 3000 g was rated as passing (preferably 500 g or more and less than 2500 g).

[0080] (Sharpness) The toothpaste composition of each example was filled into a laminated tube (manufactured by Takemoto Container Co., Ltd.) made of low-density polyethylene (LDPE) with a diameter of 19 mm and a size of 40Φ×130H. A one-touch cap (T-40Φ One-touch CAP II, manufactured by Takemoto Container Co., Ltd.) made of polypropylene with a diameter of 6 mm and a size of 39Φ×24H was attached, and the toothpaste composition was extruded from the tube for about 2.5 cm onto a paper towel. The tube was then pulled sideways at a speed of about 5 cm per second, and the length of the stringy composition was measured and evaluated according to the following criteria. A: The length of the stringy composition was less than 20 mm. B: The length of the stringy composition was 20 mm or more but less than 28 mm. C: The length of the stringy composition was 28 mm or more.

[0081]

[0082] This application claims priority based on Japanese Patent Application No. 2024-116031, filed July 19, 2024, the disclosure of which is incorporated herein by reference in its entirety.

Claims

1. An oral composition comprising an abrasive and a binder, wherein the tensile return force TF5 in a 5 mm tensile test, as measured by Method 1 below, is 10 gf or more and 50 gf or less, the stringiness, as measured by Method 2 below, is 24 mm or more and 50 mm or less, and the viscosity, as measured by Method 3 below, is 100 Pa·s or less. (Method 1) Device name: Rheometer Jig used: Pressure / elasticity measuring pressure-sensitive shaft (Φ20 mm) Measurement speed: 60 mm / min Pull-up distance: 5 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to the brim with the oral composition, set in the device, and then pulled up at the measurement speed. The absolute value of the stress at the point where the pull-up distance is reached is measured. The average of three measurements is taken as the TF5. (Method 2) Device name: Rheometer Jig used: Pressure-sensitive shaft for measuring penetration degree (Φ15 mm) Measurement speed: 1000 mm / min Pull-up distance: 50 mm Filling container: 30 mL plastic jar (diameter 43 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, it is pulled up at the measurement speed. During pulling, the distance until the oral composition separates from the jig used is measured. The average value of three measurements up to the pull-up distance is taken as the spinnability. (Method 3) Device name: Brookfield type viscometer, rotor No. 4 Measurement speed: 12 rpm, 5M range Measurement time: 60 seconds Filling container: 19 mL vial (diameter 27 mm) Procedure: The filling container is filled to the brim with the oral composition, and after setting it in the device, the viscosity is measured at the measurement speed and for the measurement time.

2. The oral composition of claim 1, wherein the binder comprises a thickening silica.

3. The oral composition of claim 1 or 2, wherein the binder comprises an organic binder.

4. The oral composition according to claim 3, wherein the organic binder is one or more selected from the group consisting of carboxymethyl cellulose and its salts, xanthan gum, alginic acid and its salts, polyacrylic acid and its salts, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, and carrageenan (excluding κ-carrageenan).

5. An oral composition according to any one of claims 1 to 4, wherein the abrasive comprises abrasive silica.

6. An oral composition according to any one of claims 1 to 5, further comprising a humectant.

7. An oral composition according to any one of claims 1 to 6, which is a dentifrice composition.

8. An oral composition according to any one of claims 1 to 7, which is a toothpaste composition.

9. A dentifrice comprising the oral composition according to any one of claims 1 to 8 packed in a tube container.

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