Spleen-invigorating and dampness-eliminating medicinal and edible homologous composition, and preparation method therefor and use thereof

Abstract

A spleen-invigorating and dampness-eliminating medicinal and edible homologous composition, and a preparation method therefor and use thereof. The medicinal and edible homologous composition comprises the following raw material components in parts by mass: 3-30 parts of Codonopsis pilosula, 5-40 parts of lotus seeds, 10-40 parts of coix seeds, 10-40 parts of Gordon Euryale seeds, 1-15 parts of dried tangerine peels, and 5-30 parts of wolfberry. Aiming at individuals with spleen deficiency accompanied by dampness, whose main manifestations comprise being overweight, heaviness in the hands, feet, head, or body, bland or astringent taste in the mouth, loose or watery stools, etc., the method of syndrome differentiation and treatment in Traditional Chinese Medicine is adopted to invigorate the spleen and eliminate dampness, while also astringing the intestines to stop diarrhea. Moreover, the composition also takes into account the congenital foundation by regulating kidney yang. The composition can effectively ameliorate symptoms, such as being overweight, heaviness in the hands, feet, head, or body, bland or astringent taste in the mouth, loose or watery stools, etc., in individuals with spleen deficiency accompanied by dampness.

Description

A spleen-invigorating and dampness-dispelling medicinal and edible composition, a preparation method and application thereof TECHNICAL FIELD The present application belongs to the field of health food, and particularly relates to a spleen-invigorating and dampness-dispelling medicinal and edible composition, a preparation method and application thereof. BACKGROUND The Lingnan region in China has a humid climate. In the Qing Dynasty, a Guangdong physician, He Mengyao, mentioned in Medical Notes: Dampness in the Middle that "the land is low and the humidity is particularly high, with fog in the morning and evening, and heavy rain in spring and summer, so many people suffer from dampness". The dampness is caused by the damp earth and the dampness is the long summer qi. From the Dog Days to the autumnal equinox every year is the time when spleen diseases and dampness diseases occur more frequently. If people stay in such a region and climate for a long time, the spleen and stomach qi will be damaged, phlegm-dampness will accumulate, and symptoms of spleen deficiency with dampness such as body obesity, heaviness of the hands and feet or the head and body, tasteless or dry mouth, and loose or rotten stool will occur. However, "dampness is the most common disease, and many people do not feel the dampness coming, but only know to avoid cold and wind, without knowing to avoid dampness, because the harm of dampness is the most slow and hidden, and difficult to be perceived" (Medical Notes). Even if people are affected by dampness, no symptoms may occur, but at this time, "prevention is better than cure". For "prevention is better than cure", traditional Chinese medicine advocates taking care of and supporting the body's healthy qi through food, acupuncture, massage, qigong, and rest adjustment. Dampness is heavy, turbid, and sticky, and is easy to be transmitted and changed, and is often accompanied by other evils, and is difficult to be removed. Although there are many methods for dispelling dampness, if the strength of dispelling evils and supporting the healthy qi is not properly controlled, the situation of dispelling evils but damaging the healthy qi or supporting the healthy qi but causing turbidity and stagnation may occur, especially for people with spleen deficiency with dampness who have no obvious symptoms. People with spleen deficiency with dampness generally tend to take health products or herbal teas to improve symptoms because the symptoms are not serious. The effect of the health products or herbal teas on the market for people with spleen deficiency with dampness is not satisfactory, and the symptoms of people with spleen deficiency with dampness such as body obesity, heaviness of the hands and feet or the head and body, tasteless or dry mouth, and loose or rotten stool cannot be obviously improved, so it is necessary to develop a health product or a medicinal and edible herbal tea which can effectively improve the symptoms of people with spleen deficiency with dampness. SUMMARY The first object of the present application is to provide a spleen-invigorating and dampness-dispelling medicinal and edible composition, the second object of the present application is to provide a preparation method of the spleen-invigorating and dampness-dispelling medicinal and edible composition, and the third object of the present application is to provide an application of the spleen-invigorating and dampness-dispelling medicinal and edible composition. According to the first aspect of the present application, a spleen-invigorating and dampness-dispelling medicinal and edible composition is provided, and the raw material composition of the spleen-invigorating and dampness-dispelling medicinal and edible composition includes, in mass parts, 3-30 parts of radix codonopsis, 5-40 parts of lotus seed, 10-40 parts of coix seed, 10-40 parts of gordon euryale seed, 1-15 parts of dried tangerine or orange peel, and 5-30 parts of medlar. The present application considers that the dampness is the main pathogen in Lingnan area, and the disease is mainly caused by spleen deficiency combined with dampness, and the symptoms of spleen deficiency diarrhea often occur. Although the treatment should be based on the method of invigorating the spleen and removing dampness, it should also be combined with the method of tonifying the kidney and astringing the intestine to stop diarrhea, preventing the continuous diarrhea from further consuming the kidney yang. The present application is aimed at the people with spleen deficiency combined with dampness, whose main manifestations are body overweight, heavy hands and feet or head and body, light or dry mouth, loose or rotten stool, etc. The present application adopts the method of TCM syndrome differentiation and treatment, and proposes the present application of the medicine-food homologous composition, which invigorates the spleen and removes dampness, and astringes the intestine to stop diarrhea, and adjusts the kidney yang at the same time. In the prescription, Codonopsis pilosula has a sweet and flat taste, can nourish the spleen and stomach, and can invigorate the middle qi; Coix seed has a sweet and flat taste, and can invigorate the spleen, remove dampness and stop diarrhea; the two are the monarch herbs, and can invigorate the spleen and remove dampness. Lotus seed and Euryale seed have a sweet and astringent taste and a flat nature, Lotus seed can “greatly benefit the spleen and stomach, and has the astringent nature, which is most suitable for people with diarrhea, spermatorrhea and loose stool” (Yujia Yaji, Jade Interpretation of Medicine), Euryale seed can “tonify the middle and remove dampness, and has a non-dry nature, so it can remove pathogenic water and tonify true water, and can especially assist the yin-tonifying herbs to add essence, without worrying about the increase of dampness. Euryale seed not only benefits essence, but also astringes essence and tonifies the kidney” (Bencao Xinbian, New Compilation of Materia Medica), and Wolfberry has a sweet taste and a flat nature, and belongs to the liver, kidney and spleen channels, “has a heavy and pure taste, so it can tonify yin, and has yang in yin, so it can tonify qi. Therefore, it can tonify yin without causing yin deficiency, and can assist yang without causing yang excess” (Bencao Zheng, Correct Materia Medica). Lotus seed, Euryale seed and Wolfberry are the minister herbs, which are used with the monarch herb, so that they can remove dampness without damaging yin, and tonify without stagnation, and have the effect of invigorating the spleen, tonifying the kidney and astringing the intestine to stop diarrhea. Orange peel has a bitter and pungent taste and a warm nature, which can assist the monarch herb to invigorate the spleen and remove dampness, and can also regulate qi and remove stagnation, and tonify qi to prevent stagnation. The medicine-food homologous composition of the present application has a flat nature, and invigorates the spleen and removes dampness, and removes dampness and astringes the intestine at the same time, so that it can invigorate the spleen, remove dampness, tonify the kidney and astringe the intestine to stop diarrhea, and can obviously improve the clinical symptoms of people with spleen deficiency combined with dampness, such as body overweight, heavy hands and feet or head and body, light or dry mouth, loose or rotten stool, etc. The raw materials of the present application are as follows: Codonopsis pilosula (Franch.) Nannf. is a plant of Codonopsis pilosula (Franch.) Nannf. of the family of Cucurbitaceae, and the root of Codonopsis pilosula Nannf. var. (Nannf.) L.T.Shen or C. tangshen Oliv. Lotus seed is the mature seed of Nelumbo nucifera Gaertn. of the family of Nelumbonaceae. Coix seed is the dried mature seed of Coix lacryma jobi L.var. mayuen (Roman.) Stapf of the family of Poaceae. Euryale seed is the mature seed of Euryale ferox Salisb. of the family of Nelumbonaceae. Orange peel is the dried mature pericarp of Citrus reticulata Blanco and its cultivated varieties of the family of Rutaceae. Goji berry: The mature fruit of Lycium barbarum L., a plant belonging to the Solanaceae family. In some implementations, the Job's tears are stir-fried. Stir-frying removes the cold properties of Job's tears and enhances their ability to strengthen the spleen, dispel dampness, and stop diarrhea. In some embodiments, the dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is an oral solution, powder, or granule. In some implementations, food-acceptable additives may also be added. In some embodiments, the excipient is at least one selected from the following: sustained-release agent, excipient, filler, binder, wetting agent, disintegrant, absorption promoter, adsorbent carrier, surfactant, and lubricant. According to a second aspect of the present invention, a method for preparing the above-mentioned spleen-strengthening and dampness-removing medicinal and edible composition is provided. When the dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is an oral solution, the preparation method includes the following steps: Soak the raw materials in 8-12 times their weight of water for 20-40 minutes, then heat to boiling and maintain a gentle boil for 1-2 hours. Filter, and repeat the decoction process 1-2 times on the residue. Combine the filtrates to obtain the final product. The oral solution is further packaged after cooling, making it easy to carry and distribute. According to a third aspect of the present invention, a method for preparing the above-mentioned spleen-strengthening and dampness-removing medicinal and edible composition is provided. When the dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is a powder, the preparation method includes the following steps: Crush or chop each raw material separately, then pass the crushed or chopped raw materials through 10-mesh and 50-mesh sieves respectively. Continue to crush or chop the coarse particles that cannot pass through the 10-mesh sieve, and take the powder that is between the 10-mesh and 50-mesh sieves. Then mix the powders of each raw material according to the formula, put them into a packaging bag, and seal it. According to a fourth aspect of the present invention, the application of the above-described spleen-strengthening and dampness-removing medicinal and edible composition in the preparation of medicinal and edible health foods that improve symptoms of spleen deficiency with dampness is provided. Specifically, symptoms of spleen deficiency with dampness include being overweight, heaviness in the hands, feet, or head and body, bland taste in the mouth, astringent taste in the mouth, and loose or watery stools. Medicinal and edible health foods include medicinal and edible substitute teas, lozenges, and effervescent tablets. The ingredients in the food-medicine homology composition of this invention, namely Codonopsis pilosula, lotus seed, Coix seed, Euryale ferox, dried tangerine peel, and wolfberry, are substances that are "both food and traditional Chinese medicine" (as stated in the "Notice of the Ministry of Health on Further Regulating the Management of Raw Materials for Health Foods").

[2002] According to Announcement No. 51 and Announcement No. 9 of 2023, regarding 9 newly added substances that are traditionally both food and Chinese medicinal materials, the raw materials in the formula are all Chinese medicinal materials that can be used in health food, and their sources are safe and reliable. The raw materials of the spleen-strengthening and dampness-removing medicinal and edible composition have the characteristics of medicinal and edible homology and safe medication, and can be prepared into medicinal and edible health-care food such as medicinal and edible substitute tea, buccal tablets, effervescent tablets and the like. Illustratively, the preparation method of the medicinal and edible substitute tea comprises the following steps: respectively drying Dangshen, Lotus Seed, Yiyiren, Qianshi, Chenpi and Gouqi to a moisture content of <3.0%, removing impurities and inferior raw materials, and then performing ultraviolet sterilization, and then weighing each raw material according to the raw material ratio, and then uniformly mixing to obtain the medicinal and edible substitute tea. The obtained medicinal and edible substitute tea is packaged with gauze tea bags, and is used by brewing with about 100 mL of warm boiled water for drinking. The medicinal and edible substitute tea has a good improvement effect on the symptoms such as body obesity, heavy hands and feet or head and body, light taste, dry mouth, loose or rotten stool and the like of the spleen deficiency and dampness population, and is suitable for long-term drinking. The beneficial effects of the present application include: (1) The spleen-strengthening and dampness-removing medicinal and edible composition can effectively improve the symptoms such as body obesity, heavy hands and feet or head and body, light taste or dry mouth, loose or rotten stool and the like of the spleen deficiency and dampness population. (2) The present application does not use greasy and drastic tonifying products, but mainly uses sweet and flat products, and is supplemented with qi-regulating drugs, and through ingenious compatibility, tonification without stagnation, and both symptoms and root causes are considered, the spleen is strengthened and dampness is removed, and the kidney is also considered, and the intestine is also considered to stop diarrhea, so as to prevent excessive dampness. Clinical research shows that the spleen-strengthening and dampness-removing medicinal and edible composition can significantly improve the symptoms such as body obesity, heavy hands and feet or head and body, light taste or dry mouth, loose or rotten stool and the like of the spleen deficiency and dampness population. DETAILED DESCRIPTION The following will be further described in combination with specific embodiments, and it should be noted that the following embodiments are only for better explaining the content of the present application, and do not limit the scope of protection of the present application. The process steps not disclosed in the embodiments are prior art. Unless otherwise specified, the following raw materials are commercially available. Example 1 The raw material composition of the spleen-strengthening and dampness-removing medicinal and edible oral solution of the present embodiment is as follows: Dangshen 10 g, Lotus Seed 20 g, fried Yiyiren 20 g, Qianshi 30 g, Chenpi 2 g, Gouqi 10 g. The preparation method thereof comprises the following steps: (1) The raw materials are soaked in 10 times by weight of water for 30 minutes, and then heated to boiling, and kept at a slight boil for 1 hour, and then separated to obtain the first decoction and the residue; the residue obtained after the first decoction is added with 8 times by weight of water corresponding to the total mass of the raw materials, heated to boiling, and kept at a slight boil for 1 hour, and then separated to obtain the second decoction and the residue; the first decoction and the second decoction are combined to obtain the oral solution. (2) The obtained oral solution is cooled and then packaged. The ratio is one dose of medicine, and one dose of medicine is about 150 mL. Example 2 The Spleen-Invigorating and Damp-Expelling Diaphoretic Powder of the present embodiment has the following raw material components: Radix Codonopsis 10 g, Lotus Seed 20 g, Fried Semen Coicis 20 g, Semen Euryale 30 g, Tangerine Peel 2 g, and Fructus Lycii 10 g. The preparation method thereof comprises the following steps: (1) Take Radix Codonopsis, crush, and pass through 10-mesh and 50-mesh screens at the same time. The coarse particles that cannot pass through the 10-mesh screen are continuously crushed, and the powder located between the 10-mesh screen and the 50-mesh screen is taken; (2) The Lotus Seed, Fried Semen Coicis, Semen Euryale, Tangerine Peel, and Fructus Lycii are respectively crushed into powder according to the method of step (1); (3) The powder of each raw material is mixed uniformly, and then is filled into a sealing bag and sealed. Example 3 The Spleen-Invigorating and Damp-Expelling Diaphoretic Powder of the present embodiment has the following raw material components: Radix Codonopsis 10 g, Lotus Seed 20 g, Fried Semen Coicis 20 g, Semen Euryale 30 g, Tangerine Peel 2 g, and Fructus Lycii 10 g. The preparation method thereof is the same as that of Example 1. Example 4 The Spleen-Invigorating and Damp-Expelling Diaphoretic Powder of the present embodiment has the following raw material components: Radix Codonopsis 10 g, Lotus Seed 20 g, Fried Semen Coicis 20 g, Semen Euryale 30 g, Tangerine Peel 2 g, and Fructus Lycii 10 g. The preparation method thereof is the same as that of Example 2. The Spleen-Invigorating and Damp-Expelling Diaphoretic Powder of the present embodiment has the following raw material components: Radix Codonopsis 10 g, Lotus Seed 20 g, Fried Semen Coicis 20 g, Semen Euryale 30 g, Tangerine Peel 2 g, and Fructus Lycii 10 g. The 31 patients with spleen deficiency and dampness were aged 22-67 years, with an average age of 36.7 years, including 16 males and 15 females. The main symptoms before taking the medicine included heavy head and body, light or dry mouth, and loose or rotten stool. The self-symptoms of the 31 patients with spleen deficiency and dampness before and after taking the Spleen-Invigorating and Damp-Expelling Diaphoretic Powder of Example 1 were compared, and the results are shown in Table 1. Table 1 Statistical analysis table of the influence of the Spleen-Invigorating and Damp-Expelling Diaphoretic Powder on the symptoms of patients with spleen deficiency and dampness As can be seen from Table 1, the average symptom scores of patients after taking the Spleen-Invigorating and Damp-Expelling oral solution of the present application are lower than those before taking the medicine (P<0.05), indicating that the Spleen-Invigorating and Damp-Expelling composition of the present application is significantly effective in improving the symptoms of patients with spleen deficiency combined with dampness, such as heavy head, light taste, dry mouth, loose stool or stool with rancidity. The above merely describes some specific embodiments of the present application. For those skilled in the art, without departing from the inventive concept, several modifications and improvements can be made, which shall all fall within the protection scope of the present application.

Claims

1. A pharmafood composition for strengthening the spleen and expelling dampness, characterized in that, The raw material composition includes 3-30 parts of radix codonopsis, 5-40 parts of lotus seed, 10-40 parts of coix seed, 10-40 parts of gordon euryale seed, 1-15 parts of dried tangerine or orange peel, and 5-30 parts of medlar, in terms of mass parts.

2. The spleen-invigorating and damp-dispelling pharmacologically identical composition as claimed in claim 1, wherein The coix seed is fried coix seed.

3. The spleen-invigorating and dampness-dispelling pharmacologically identical composition according to claim 1 or 2, characterized in that, The dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is oral solution, powder or granules.

4. The spleen-invigorating and dampness-expelling pharmacognosy composition according to claim 1 or 2, characterized in that, Food acceptable adjuvants can also be added.

5. The spleen-invigorating and damp-dispelling pharmacologically identical composition as claimed in claim 4, wherein The adjuvant is at least one of sustained-release agent, excipient, filler, binder, humectant, disintegrating agent, absorption promoter, adsorption carrier, surfactant, lubricant.

6. A process for the preparation of the spleen strengthening and damp eliminating medicinal and food composition as claimed in any of the claims 1 to 5, wherein, When the dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is oral solution, the preparation method includes the following steps: The raw materials are soaked in 8-12 times of water by weight for 20-40 minutes, then heated to boiling, and kept at micro-boiling for 1-2 hours. The filtrate is obtained by filtering and repeating decocting the residue 1-2 times.

7. A process for the preparation of the spleen strengthening and damp eliminating medicinal and food composition as claimed in any of claims 1 to 5, wherein, When the dosage form of the spleen-strengthening and dampness-removing medicinal and edible composition is powder, the preparation method includes the following steps: The raw materials are respectively crushed or cut into pieces, then the crushed or cut raw materials are respectively passed through 10-mesh and 50-mesh screen, the coarse particles that cannot pass through the 10-mesh screen are further crushed or cut into pieces, the powder between the 10-mesh and 50-mesh screens is taken, then the raw material powders are mixed according to the ratio, and packed in a sealed bag.

8. Use of the spleen-strengthening and dampness-removing medicinal and edible composition of any one of claims 1-5 in the preparation of medicinal and edible health food for improving symptoms of spleen deficiency with dampness.

9. Use according to claim 8, characterized in that, The symptoms of spleen deficiency with dampness include body overweight, heavy hands and feet or head and body, tasteless mouth, dry mouth, loose or rotten stool.

10. Use according to claim 8 or 9, characterized in that, The medicinal and edible health food includes medicinal and edible substitute tea, buccal tablets, effervescent tablets.

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