A novel topical eradication for skin disease

Abstract

The presented invention is meant to replace all traditional treatments for the skin (topical, systemic), It is developed for oily skin, but can be used by anyone. Unlike traditional treatment it is effective all of the time. Consists of a 2-phase solution, emulsion or liposomes, that is topical. The 2 phases can be adjusted independently, as long as droplet size are smaller than skin pores (20-150μm) and have the right surface polarity to enter skin pores for effective treatment. It is better than existing systemic treatments by the ratio of drug solubilities, typically by 100x. By reducing the drug phase, droplet size is reduced for easier skin pore emtry and if organic don't cause skin burns.

Description

[0001] Description

[0002] Title: A Novel Topical Eradication for Skin Disease:^

[0003] 1]

[0004] Technical Field

[0005] [2]

[0006] This method uses water / organic emulsions for organic and liposomes for water soluble drug delivery.

[0007] It combines the advantages of topical treatment (minimal toxicity, targeted action) with the efficiency of systemic treatments (cure). Its benefits over existing methods are manyfold and although developed with oily skin patients in mind it is good to be used by anyone

[0008] Background Art

[0009] [3]

[0010] Summary of Invention

[0011] [4]

[0012] This method uses water / organic emulsions for organic and liposomes for water soluble drug delivery.

[0013] Technical Problem

[0014] [1]

[0015] Eradication has been around since the 1960s, and is the only treatment for serious skin disease..Never worked as intended and when faced with a bit different case, like oily skin, doesn’t work at all

[0016] Solution to Problem

[0017] [2]

[0018] This invention attempts to update it, and replace existing skin treatments(topical, systemic). It is effective in every case where an eradication is needed.

[0019] Advantageous Effects of Invention

[0020] 1) It is topical and very easy to use. All effects and toxicity are limited to the skin, external to the body. Doesn’t enter the body like existing eradications. Acts like topical gels. Unlike systemic treatment, patient can start anytime without concerns about other systemic treatments he may be using (i.e. statins and fungicides). Combination treatment as needed, as long as there isn’t a x- reaction from the drugs in the emulsion. X-reaction can be tested with a few drops from each emulsion in a cup and watching for any changes in appearance. Even then, it is possible to use both the emulsions, at different skin areas, or after sometime (3 hrs) have elapsed between applications.

[0021] 2) It is targeted to the problem area, like the face, contrary to traditional eradications that treat the whole body. Targeted action means concentrated activity, Its topical action means that it has to be used over all of the skin’s affected areas.

[0022] 3) It is delivered to the skin with qTips immediately. Systemic methods are taken internally through the digestive track, to the circulatory system and finally to the skin pores. That’s several steps that take considerable time (~30’).

[0023] 4) It is delivered as a 2-phase solution, which are independently adjusted. Drug is completely dissolved in the first phase, called the “drug phase” from now on, giving it 100% activity while supplementary medication may be dissolved to the “aqueous” or “main phase” for better control of the symptoms.. In the systemic methods drug is delivered through the oral (pill) or circulatory (injection) systems, which are water based. If faced with organic soluble drugs, very little of the drug is dissolved (could even be 1%) reducing its efficacy. Even water soluble drugs like ciproflaxosin, may require special solutions for maximal activity (16% acetic acid).

[0024] Even though doctors have stopped prescribing antibiotics for viruses since 2000, resistance in the wild is still rising. Now the resistance vector is the traditional eradications. When only 1 % is used for treatment the other 99% is being excreted through the wastes. When they meet a large body of water (> 10 It) the white powder completely dissolves and activates. Waste treatment plants cannot stop dissolved substances and release it to the environment. This method uses 100% of the drug, where is used up to kill the pathogen. It is imperative that traditional eradications are stopped. Doctors are not at fault this time. Pharma are to blame for this: (

[0025] 5) Because of its enhanced activity, doesn’t need to use disinfectants like traditional eradications. This results in an easier procedure with fewer errors. In fact traditional eradications, never quite worked well. That’s why to even work they need to use disinfectants.

[0026] 6) The 2 phases can be adjusted independently. By reducing the drug phase we are able to minimize / avoid skin burns (if drug phase is organic), unlike topical gels.

[0027] 7) The size of the droplets (emulsion) or in the liposomes can be adjusted so that they can readily fit and enter skin pores, where they can be effective. Unlike topical remedies who cannot enter skin pores and cannot be used for treatment

[0028] Description of Embodiments Examples

[0029] [3]

[0030] A) Topical eradication of M. Furfur from face.

[0031] We use fluconazole. It is very soluble in ethanol and very little in water. Recommended procedure is topical eradication with 100 ml emulsion.

[0032] To prepare 100 ml emulsion of 1% fluconazole for the example, we use 5 stabilanol 200 mg capsules (200 x5 = 1 g), a dish, a 100 ml plastic bottle and plastic cup and 10 ml ethanol. We open the capsules and empty the white powder to the dish. We pour 10 ml ethanol to the plastic cup and we dissolve in it the white dust. We fill the plastic bottle with 90 ml water. We transfer the fluconazole solution, to the bottle and shake. Caution, the insoluble inactive carriers (sugar, cellulose, etc) are left behind.

[0033] Emulsion characteristics: Long self life at room temperature. 100x more drastic than the capsule, due to enhanced solubility. Topical toxicity due to ethanol is reduced to 90% of that of the dermaspor gel. It doesn’t cause skin burns. Gentle enough to be used even at eyelids. Application is done with qTips. From dispersion studies of ouzo (a Greek alcoholic drink) in water, alcohol microdroplets are smaller than 5 - 10 pm, enough to fit through skin pores (20 - 150 pm).

[0034] Treatment, of serious M. Furfur infection, where the pathogen has entered skin pores, and the face was filled with sores, 1 month stabilanol (200 mg) treatment didn’t have any effect. Internally taken fungicides have serious toxicity (depending on the dose).

[0035] 2 weeks treatment 2x / day with the emulsion eradicated the fungus. Because of the higher activity of the treatment, no disinfectant was used. A repeat was necessary 2 weeks later to finish gff any remaining spores.

[0036] The emulsion is preferable even for simple superficial skin infections, treatable locally with dermaspor gel, where the infection hasn’t entered skin pores. Dermaspor causes skin burns, due to the alcohol it contains. It necessitates use of moisturizer before its use. It cannot be used in sensitive areas like the eyelids. The emulsion is gentle enough not to need such precautions, and with only 10% alcohol in 90% water can be used without concern in the eyelids.

[0037] BjTopical eradication of M.Morganii from body

[0038] We use cexifime. It is very soluble in methanol and very little in water.

[0039] Recommended procedure is topical eradication with 100 ml emulsion. To prepare 100 ml emulsion of ,4% cexifime for the example, we use 1 ceftoral 400 mg pill, a dish, a 100 ml plastic bottle and plastic cup and 10 ml methanol. We crush the pill in the dish to a fine powder. We pour 10 ml methanol to the plastic cup and dissolve in it the powder. We fill the plastic bottle with 90 ml water. We transfer the cexifime solution, to the bottle and shake. Caution, the insoluble inactive carriers (sugar, cellulose, etc) are left behind.

[0040] Emulsion characteristics: Long self life at room temperature. 100x more drastic than the pill due to enhanced solubility. Topical toxicity due to methanol not existent. Gentle enough to be used even at eyelids. Application is done with disposable plastic gloves. Similar appearance ro the (A) emulsion, methanol microdroplets should be smaller than 5 - 10 pm, enough to fit through skin pores (20 - 150 pm).

[0041] Treatment, of serious M. Morganii infection, where the pathogen has entered the skin pores, and body is filled with sores, 1 mo ceftoral (400 mg) treatment didn’t have any effect. Internally taken have can have side effects (diarrhea, etc). 2 weeks treatment 2x / day with the emulsion eradicated the pathogen. Because of the higher activity of the treatment, no disinfectant was used.

[0042] Currently there is no topical cefixime gel, so, this emulsion can be used for simple cases as well.

[0043] Industrial Applicability

[0044] [3]

[0045] Changes in the production line of the plant are minimal, especially if components for emulsions or liposomes already exist for other products.

[0046] Reference Signs List

[0047] [4]

[0048] Reference to Deposited Biological Material

[0049] [5]

[0050] Sequence Listing Free Text

[0051] [6]

[0052] Citation List

[0053] [7]

[0054] Patent Literature

[0055] [8] PTL1 :

[0056] Non Patent Literature [9] NPL1:

Claims

Claims

1. This invention is a 2- phase solution, emulsion or liposomes for the topical treatment of known serious or superficial skin disease. By adjusting freely the 2 phases, and reducing the drug phase, we can:

2. Reduce any skin burns by the organic phase

3. The created microdroplets (emulsions) or liposomes must be sufficiently small and use the right surface polariry to enter skin pores for effective treatment.

4. The drug phase must be the best solvent for the drug to guarantee maximum drug activity

5. The aqueous main phase can be used for supplementary treatment, of the skin surface. As an example we could use a 3% Salicylic acid (anti-inflammatory) to further control immune response and reduce symptoms. In some patients head hair loss can be a symptom of the disease.