Stabilization of thiopyridinone compound and composition comprising same

Abstract

The present invention relates to a composition comprising: (a) at least one thiopyridinone compound; and (b) at least one compound selected from ergothioneine and derivatives thereof. The present invention can provide a composition including (a) thiopyridinone compound(s) with increased stability of the (a) thiopyridinone compound(s) over time, in particular even when the composition is maintained for a relatively long period of time under elevated temperature.

Description

[0001] DESCRIPTION

[0002] TITLE OF INVENTION

[0003] STABILIZATION OF THIOPYRIDINONE COMPOUND AND COMPOSITION COMPRISING SAME

[0004] TECHNICAL FIELD

[0005] The present invention relates to the stabilization of a thiopyridinone compound in a composition including the thiopyridinone compound.

[0006] BACKGROUND ART

[0007] At various periods of their lives, some people see the appearance on their skin, and more in particular on their faces and hands, of darker and / or more colored spots, which give the skin heterogeneity. These spots are in particular due to a high concentration of melanin in the keratinocytes located at the surface of the skin.

[0008] The use of harmless topical depigmenting substances with good efficacy is most particularly desired for the purpose of treating pigmentation spots.

[0009] For example, arbutin, niacinamide and kojic acid are known as skin depigmenting agents.

[0010] On the other hand, WO2017 / 102349 discloses a new depigmenting or whitening agent, i.e., a thiopyridinone compound. The thiopyridinone compound can show strong depigmenting or whitening effects by reducing the production of melanin.

[0011] DISCLOSURE OF INVENTION

[0012] However, it has been discovered that a thiopyridinone compound tends to be destabilized in a composition over time, in particular when the composition including the thiopyridinone compound is maintained for a relatively long period of time under elevated temperature.

[0013] Thus, an objective of the present invention is to provide a composition including thiopyridinone compound(s) with increased stability of the thiopyridinone compound(s) over time, in particular when the composition is maintained for a relatively long period of time under elevated temperature.

[0014] The above objective can be achieved by a composition, preferably a cosmetic composition, and more preferably a skin cosmetic composition, comprising:

[0015] (a) at least one first compound selected from compounds of formula (I) below, tautomers of formula ( l') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof: in which

[0016] Ri denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, and

[0017] R2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals wherein

[0018] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group; and

[0019] (b) at least one second compound selected from ergothioneine and derivatives thereof.

[0020] It may be preferable that:

[0021] R1of formula (I) and (I') represents a hydrogen atom; or

[0022] R1of formula (I) and (I') represents a linear (C1-C10) alkyl group or a branched (C3-C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably ethyl, particularly the said alkyl group of Ri is not substituted.

[0023] It may be preferable that:

[0024] R2of formula (I) and (I') represents a hydrogen atom; or

[0025] R2of formula (I) and (I') represents a linear (C1-C10) alkyl group or a branched (C3-C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl group; the said alkyl group of R2being not substituted. It may be preferable that:

[0026] R2of formula (I) and (I') represents a linear (C1-C10) alkyl group or a branched (C3-C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl; the said alkyl group being substituted by one or more groups selected from i), ii), iii) and iv) as defined above, preferably the said alkyl group being substituted by one or two groups selected from i), ii) and iii), more preferably by one or two groups selected from i) and iii), better substituted by one group iii) as carboxy.

[0027] It may be preferable that:

[0028] R2of formula (I) and (I') represents a (C3-C8) cycloalkyl group, preferably a (C5-C7) cycloalkyl group such cyclohexyl; or

[0029] R2of formula (I) and (I') represents a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, preferably a phenyl group particularly not substituted.

[0030] It may be preferable that:

[0031] R3of formula (I) and (I') represents a hydrogen atom; or

[0032] R3of formula (I) and (I') represents a saturated, linear C1-C10or branched C3-C10alkyl group; particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably a (C1- C4) alkyl group such as methyl group.

[0033] It may be more preferable that:

[0034] R1of formula (I) and (I') represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C6or branched C3-C6alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, preferably optionally substituted with one or more groups i);

[0035] R2of formula (I) and (I') represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10or cyclic C3-C8such as C5-C6hydrocarbonated group, optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a phenyl group optionally substituted with one or more hydroxyls and / or with one or more C1-C4alkoxy radicals such as methoxy, preferably substituted with one or more groups selected from i) and iii), preferably iii) such as carboxy; and

[0036] R3of formula (I) and (I') represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C6or branched C3-C6alkyl group, preferentially, the compounds of formula (I) and tautomer (I'), salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof, have the following meanings:

[0037] Ri of formula (I) and (I') represents a radical chosen from: a) a hydrogen atom, and b) a saturated, linear C1-C4or branched C3-C4alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -OR3, more preferably not substituted;

[0038] R2of formula (I) and (F) represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10or cyclic C3-C8such as C5-C6hydrocarbonated group, optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C4alkoxy radicals; and

[0039] R3of formula (I) and (I') represents a radical chosen from: a) a hydrogen atom; b) a saturated, linear C1-C4or branched C3-C4alkyl group such as methyl or ethyl.

[0040] The (a) first compound may be selected from the compounds 1 to 24 below, tautomers thereof, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof, particularly the compounds 1, 2, 4, 6, 7, 9, 11, 12, 14, 15, 16, 17, 18, 19, 20, or 21, more particularly 1, 9, 16, 18, 19, 20, or 21, preferably 18, 19, 20, or 21, and more preferably 20: The amount of the (a) first compound(s) in the composition according to the present invention may be from 0.001% to 10% by weight, preferably from 0.005% to 5% by weight, and more preferably from 0.01% to 3% by weight, relative to the total weight of the composition.

[0041] The (b) second compound may be represented by the following chemical formula (II): in which:

[0042] X represents a group -O-R', -O-M or -NR'R";

[0043] R, R' and R" represent, simultaneously or independently of each other, a hydrogen atom, an alkyl, alkenyl or acyl group of C1-C18, the alkyl, alkenyl or acyl group being linear or branched, optionally substituted with at least one substituent selected from hydroxyl group, possibly being esterified, halogen atoms, carboxylic group and its derivatives, and amine group and its derivatives, and possibly containing in the chain at least one hetero atom such as O and S; and

[0044] M represents a cation such as a metal cation.

[0045] It may be preferable that the groups R, R' and R" of the above chemical formula (II) denote, simultaneously or independently of each other, a hydrogen atom or an ethyl, acetyl or acyl group, and preferably R denotes a hydrogen atom or an ethyl, acetyl or acyl group, and X denotes NH2.

[0046] It is more preferable that the (b) second compound is ergothioneine.

[0047] The amount of the (b) second compound(s) in the composition according to the present invention may be from 0.001% to 10% by weight, preferably from 0.005% to 10% by weight, more preferably from 0.01% to 5% by weight, relative to the total weight of the composition.

[0048] The present invention also relates to a cosmetic process, preferably a whitening process, for a keratin material, preferably skin, comprising the step of: applying to the keratin material the composition according to the present invention.

[0049] Another aspect of the present invention is a use of (b) at least one second compound selected from ergothioneine and derivatives thereof in a composition comprising (a) at least one first compound selected from compounds of formula (I) below, tautomers of formula (I') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof: in which

[0050] Ri denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3,

[0051] R2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals wherein

[0052] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group in order to stabilize the (a) first compound(s).

[0053] BEST MODE FOR CARRYING OUT THE INVENTION

[0054] After diligent research, the inventors have discovered that it is possible to provide a composition including a thiopyridinone compound or thiopyridinone compounds with increased stability of the thiopyridinone compound(s) over time, in particular even when the composition is maintained for a relatively long period of time under elevated temperature.

[0055] Thus, the composition according to the present invention comprises:

[0056] (a) at least one first compound selected from compounds of formula (I) below, tautomers of formula (T) below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof (hereafter, the compound of formula (I) or (I') is referred to as the “first compound” or “thiopyridinone compound”): in which

[0057] R1denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, and

[0058] R2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals wherein

[0059] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group; and

[0060] (b) at least one second compound selected from ergothioneine and derivatives thereof.

[0061] The composition according to the present invention can show increased stability of the (a) thiopyridinone compound therein.

[0062] In other words, the composition according to the present invention can increase the stability of the (a) thiopyridinone compound therein. The term “stability” of the (a) thiopyridinone compound can be determined by the change in the amount of the (a) thiopyridinone compound in the composition according to the present invention during a certain period of time. An increased “stability” means that the change in the amount of the (a) thiopyridinone compound over time is more limited.

[0063] The composition according to the present invention can show increased stability of the (a) thiopyridinone compound therein, even when the composition is maintained for a relatively long period of time such as two weeks and two months under elevated temperature such as 45°C and 55°C. Therefore, the composition according to the present invention can be stored for a long period of time even under hot conditions.

[0064] In addition, the increased stability of the (a) thiopyridinone compound can provide improved or enhanced bioavailability of the (a) thiopyridinone compound which can function as a depigmenting or whitening agent. Therefore, the composition according to the present invention can provide enhanced or improved depigmenting or whitening effects.

[0065] Hereafter, the composition, use and the like according to the present invention will be described in a detailed manner.

[0066] [Composition]

[0067] The composition according to the present invention comprises:

[0068] (a) at least one first compound (thiopyridinone compound); and

[0069] (b) at least one second compound selected from ergothioneine and derivatives thereof.

[0070] The (a) first compound, and the (b) second compound, as well as the other features of the composition according to the present invention will be explained below.

[0071] (First Compound)

[0072] The composition according to the present invention comprises (a) at least one first compound. Two or more (a) first compounds may be used in combination. Thus, a single type of (a) first compound or a combination of different types of (a) first compounds may be used.

[0073] The (a) first compound is selected from compounds of formula (I) below, tautomers of formula (I') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof: in which

[0074] R1denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, and

[0075] R2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals wherein

[0076] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group.

[0077] Hereafter, for the purposes of the present invention and unless otherwise indicated: a “saturated, linear C1-C12or branched C3-C12” hydrocarbonated group is equivalent to a “linear (C1-C12) alkyl or branched (C3-C12) alkyl group” which corresponds to a saturated, linear C1-C12or branched C3-C12hydrocarbon-based group, preferably a linear C1-C10or branched C3-C10hydrocarbon-based group, and more preferably a linear C1-C6or branched C3-C6hydrocarbon-based group; Preferentially, the linear or branched groups may be chosen from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl; More preferentially, the saturated linear or branched alkyl groups may be chosen from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl, pentyl, hexyl, heptyl and octyl, such as methyl, ethyl, n-pentyl, n-nonyl, and isobutyl; a saturated “cyclic C3-C8” hydrocarbonated group is a mono or bicyclic cycloalkyl group containing from 3 to 8 carbon atoms, and especially is a monocyclic cycloalkyl group in C5to C7such as a cyclohexyl group, an “alkoxy radical” is an alkyl-oxy radical for which the alkyl radical is a linear or branched C1-C16, and preferentially a C1-C8hydrocarbon-based radical; when the alkoxy group is optionally substituted, this implies that the alkyl group is optionally substituted as defined above; an “aryl” group represents a fused or non-fused monocyclic or bicyclic carbon-based group comprising from 5 to 12 carbon atoms, preferably from 6 to 10 carbon atoms, and in which at least one ring is aromatic; preferentially, the aryl radical is a phenyl, biphenyl, naphthyl, more preferably a phenyl group; the term “at least one” is equivalent to the term “one or more”; and the term "inclusive" for a range of concentrations means that the limits of that range are included in the defined range.

[0078] The salts of the compounds of formula (I), (I'), (II), or (IT) as defined below comprise the conventional non-toxic salts of said compounds, such as those formed from organic or inorganic acid or from organic or inorganic base.

[0079] As salts of the compounds of formula (I), (I'), (II), or (IT), mention may be made of: the salts obtained by addition of the compound of formula (I) or (II) to: a mineral base, such as sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, magnesium hydroxide, lithium hydroxide, and sodium, potassium or calcium carbonate or hydrogen carbonate for example; or an organic base such as a primary, secondary or tertiary alkylamine, for example triethylamine or butylamine. This primary, secondary or tertiary alkylamine may comprise one or more nitrogen and / or oxygen atoms and may thus comprise, for example, one or more alcohol functions. Mention may be made in particular of 2- amino-2-methylpropanol, ethanolamine, triethanolamine, 2-dimethylaminopropanol, 2-amino-2-(hydroxymethyl)-1,3-propanediol and 3- (dimethylamino)propylamine.

[0080] Mention may also be made of the salts of amino acids, for instance lysine, arginine, guanidine, glutamic acid and aspartic acid. Advantageously, the salts of the compounds of formula (I) or (II) (when it comprises a carboxy group) may be chosen from alkali metal or alkaline-earth metal salts such as sodium, potassium, calcium or magnesium salts and ammonium salts.

[0081] As “organic or inorganic acid salt” is more particularly chosen from salts chosen from a salt derived from i) hydrochloric acid HC1, ii) hydrobromic acid HBr, iii) sulfuric acid H2SO4, iv) alkylsulfonic acids: Alk-S(O)2OH such as methanesulfonic acid and ethanesulfonic acid; v) arylsulfonic acids: Ar-S(O) OH such as benzenesulfonic acid and toluenesulfonic acid; vi) citric acid; vii) succinic acid; viii) tartaric acid; ix) lactic acid; x) alkoxysulfinic acids: Alk-O- S(O)OH such as methoxysulfinic acid and ethoxysulfmic acid; xi) aryloxysulfinic acids such as tolueneoxysulfinic acid and phenoxysulfmic acid; xii) phosphoric acid H3PO4; xiii) acetic acid CH3C(O)OH; xiv) triflic acid CF3SO3H; and xv) tetrafluoroboric acid HBF4.

[0082] The acceptable solvates of the compounds described in the specification comprise conventional solvates such as those formed during the preparation of said compounds owing to the presence of solvents. Mention may be made, by way of example, of the solvates due to the presence of water or of linear or branched alcohols, such as ethanol or isopropanol.

[0083] The optical isomers are in particular, the enantiomers and the diastereoisomers.

[0084] Compound (I') is the tautomer form of compound (I) when a tautomeric equilibrium exists according to the following scheme:

[0085] According to one embodiment of the present invention, R1represents one hydrogen atom.

[0086] According to another embodiment of the present invention, R1represents a linear (C1-C10) alkyl group or a branched (C3-C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably ethyl. Particularly the said alkyl group of R1is not substituted.

[0087] According to one embodiment of the present invention, R2represents one hydrogen atom.

[0088] According to another embodiment of the present invention, R2represents a linear (C1-C10) alkyl group or a branched (C3-C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl group; the said alkyl group of R2being not substituted.

[0089] According to another embodiment of the present invention, R2represents a linear (C1-C10) alkyl group or a branched (C3-C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl; the said alkyl group being substituted by one or more groups selected from i), ii), iii) and iv) as defined above. Preferably the said alkyl group being substituted by one or two groups selected from i), ii), and iii), more preferably by one or two groups selected from i) and iii), better substituted by one group iii) as carboxy.

[0090] Another variant for radical R2is that the said alkyl group being substituted by one group iv) especially substituted by one phenyl group.

[0091] According to another embodiment of the present invention, R2represents a (C3-C8) cycloalkyl group, preferably a (C5-C7) cycloalkyl group such cyclohexyl.

[0092] According to another embodiment of the present invention, R2represents a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, preferably a phenyl group particularly not substituted.

[0093] According to an embodiment, R3represents a hydrogen atom.

[0094] According to another embodiment, R3represents a saturated, linear C1-C10or branched C3-C10alkyl group; particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably (C1-C4) alkyl group such as methyl group.

[0095] Preferably, the compounds of formula (I) and tautomer (I') or their salts, their optical isomers, racemates, and / or solvates thereof such as hydrates, alone or as a mixture have the following meanings:

[0096] R1denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C6or branched C3-C6alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, preferably optionally substituted with one or more groups i);

[0097] R2denotes a radical chosen from a) a hydrogen atom; b) a saturated, linear C1-C10or branched C3-C10or cyclic C3-C8such as C5-C6hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from: i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a phenyl group optionally substituted with one or more hydroxyls and / or with one or more C1-C4alkoxy radicals such as methoxy, preferably substituted with one or more groups selected from i) and iii), preferably iii) such as carboxy; and

[0098] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C6or branched C3-C6alkyl group

[0099] Preferentially, the compounds of formula (I) and tautomer (I') or their salts, their optical isomers, racemates, and / or solvates thereof such as hydrates, alone or as a mixture have the following meanings:

[0100] Ri denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C4or branched C3-C4alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -OR3, more preferably not substituted;

[0101] R2denotes a radical chosen from a) a hydrogen atom; and b) a saturated, linear C1-C10or branched C3-C10or cyclic C3-C8such as C5-C6hydrocarbonated group, optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, iii) -C(O)-O-R3, iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C4alkoxy radicals; and

[0102] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated linear C1-C4or branched C3-C4alkyl group such as methyl or ethyl.

[0103] Preferentially, the compounds of formula (I) and tautomer (I') or their salts, their optical isomers, racemates, and / or solvates thereof such as hydrates, alone or as a mixture have the following meanings:

[0104] R1is a hydrogen atom; and

[0105] R2denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C5or branched C3-C5or cyclic C3-C8such as C5-C6hydrocarbonated group, substituted with one or more groups, which may be identical or different, chosen from v) -C(O)-O-R3, preferably substituted with one group iii) - C(O)-O-R3; R2is even more preferably a saturated, linear C1-C4or branched C3-C4hydrocarbonated group substituted with one group iii) -C(O)-OR3; and

[0106] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated linear C1-C4or branched C3-C4alkyl group such as methyl or ethyl.

[0107] According to another preferred embodiment, compounds of formula (I) and tautomer (I') are selected among the compounds of formula (II) below and also the tautomers thereof of formula (II’) below, the salts thereof, the solvates thereof and the optical isomers thereof, and the racemates thereof, alone or as a mixture: In formula (II) and (II'), R1and R3have the same meaning as R1and R3in the compounds of formula (I) and (I'), and X denotes an alkylene radical -(CH2)n- with n being an integer ranging inclusively from 1 to 10, preferably ranging from 1 to 6, more preferably ranging from 1 to 4, such as 1, preferably R3represents a hydrogen atom.

[0108] Among the compounds of formula (I), the following compounds are preferably used and their tautomer or their salts, their optical isomers, racemates, and / or solvates thereof such as hydrates, alone or as a mixture :

[0109] Among these compounds, the following compounds are more particularly preferred:

[0110] More preferably, among these compounds, the following compounds are more particularly preferred:

[0111] Even more preferably, among these compounds, the following compounds are more particularly preferred: In the most preferred embodiment, the compound according to the present invention is the following:

[0112] All the compounds above can be obtained by a chemical method known by a person skilled in the art, from commercially available reagents.

[0113] The (a) first compound can be prepared in accordance with the process described in, for example, EP-A-3390363 or WO 2017 / 102349, which is herein incorporated by reference.

[0114] The (a) first compound may be an active ingredient or active compound in cosmetics or dermatological products. The term “active” ingredient or compound used herein means an ingredient or compound which has a cosmetic or dermatological active property, such as antioxidant, whitening, UV-filtering effects and anti-bacterial effects. The (a) first compound used in the present invention can function as a depigmenting, bleaching or whitening agent, and thus the composition according to the present invention may be used as a whitening product or as a cosmetic composition for a whitening keratin material.

[0115] The (a) first compound may be used as an agent for depigmenting, bleaching or whitening skin, body hairs, eyelashes or head hair, and also lips and / or nails, and preferably skin, in particular for eliminating pigmentation spots or senescence spots, and / or as an anti-tanning agent.

[0116] As the (a) first compound, a commercially available product may be used. As an example of the (a) first compound, mention may be made of, for example, Mexoryl SED sold by Noveal.

[0117] The amount of the (a) first compound(s) in the composition according to the present invention may be 0.001% by weight or more, preferably 0.005% by weight or more, and more preferably 0.01% by weight or more, relative to the total weight of the composition.

[0118] On the other hand, the amount of the (a) first compound(s) in the composition according to the present invention may be 10% by weight or less, preferably 5% by weight or less, and more preferably 3% by weight or less, relative to the total weight of the composition.

[0119] Thus, the amount of the (a) first compound(s) in the composition according to the present invention may range from 0.001% to 10% by weight, preferably from 0.005% to 5% by weight, more preferably from 0.01% to 3% by weight, relative to the total weight of the composition.

[0120] (Second Compound)

[0121] The composition according to the present invention comprises (b) at least one second compound selected from ergothioneine and derivatives thereof. Two or more second compounds may be used in combination. Thus, a single type of second compound or a combination of different types of second compounds may be used.

[0122] Ergothioneine and derivatives thereof may correspond to ergothioneine, as well as salts, esters and amides thereof.

[0123] Ergothioneine has the following chemical structure.

[0124] Ergothioneine can function as an antioxidant or an active oxygen scavenger. The examples of active oxygen include singlet oxygen, superoxide ion (superoxide anion radical), peroxide ion (hydrogen peroxide), and hydroxyl radical.

[0125] Ergothioneine derivatives may correspond to the compounds of the following formula (II): in which:

[0126] X represents a group -O-R', -O-M or -NR'R";

[0127] R, R' and R" represent, simultaneously or independently of each other, a hydrogen atom, an alkyl group, an alkenyl or an acyl group of C1-C18, and

[0128] M represents a cation such as a metal cation.

[0129] The expression “an alkyl, an alkenyl or an acyl group of C1-C18” means a linear or branched alkyl, alkenyl or acyl group containing from 1 to 18 carbon atoms, optionally substituted with at least one substituent selected from hydroxyl group (possibly being esterified itself), halogen atoms, carboxylic group and its derivatives and amine group and its derivatives, and possibly containing in the chain at least one hetero atom such as O and S.

[0130] Preferably, R, R' and R" of the above chemical formula (II) denote, simultaneously or independently of each other, a hydrogen atom or an ethyl, acetyl or acyl group, and preferably R denotes a hydrogen atom or an ethyl, acetyl or acyl group, and X denotes NH2. More preferably, the (b) second compound is ergothioneine, and especially L-(+)- ergothioneine, L-(-)-ergothioneine, D-(+)-ergothioneine or D-(-)-ergothioneine. The most preferred compound according to the invention is L-(+)-ergothioneine.

[0131] As the (b) second compound, a commercially available product may be used. As an example of the (b) second compound, mention may be made of, for example, Bioyouth™ EGT Pure Ultrapure Ergothioneine sold by Bloomage Biotech.

[0132] The amount of the (b) second compound(s) in the composition according to the present invention may be 0.001% by weight or more, preferably 0.005% by weight or more, and more preferably 0.01% by weight or more, relative to the total weight of the composition.

[0133] On the other hand, the amount of the (b) second compound(s) in the composition according to the present invention may be 15% by weight or less, preferably 10% by weight or less, and more preferably 5% by weight or less, relative to the total weight of the composition.

[0134] Thus, the amount of the (b) second compound(s) in the composition according to the present invention may range from 0.001% to 15% by weight, preferably from 0.005% to 10% by weight, more preferably from 0.01% to 5% by weight, relative to the total weight of the composition.

[0135] The weight ratio of the amount of the (a) first compound(s) to the amount of the (b) second compound(s), in the composition according to the present invention, may be 0.1 or more, preferably 0.2 or more, and more preferably 0.3 or more.

[0136] On the other hand, the weight ratio of the amount of the (a) first compound(s) to the amount of the (b) second compound(s), in the composition according to the present invention, may be 3 or less, preferably 2 or less, and more preferably 1 or less.

[0137] Thus, the weight ratio of the amount of the (a) first compound(s) to the amount of the (b) second compound(s), in the composition according to the present invention, may range from 0.1 to 3, preferably from 0.2 to 2, and more preferably from 0.3 to 1.

[0138] (Water)

[0139] The composition according to the present invention may comprise (c) water.

[0140] The amount of the (c) water in the composition according to the present invention may be 30% by weight or more, preferably 35% by weight or more, and more preferably 40% by weight or more, relative to the total weight of the composition.

[0141] On the other hand, the amount of the (c) water in the composition according to the present invention may be 99% by weight or less, preferably 95% by weight or less, and more preferably 90% by weight or less, relative to the total weight of the composition.

[0142] Thus, the amount of (c) water in the composition according to the present invention may be from 30% to 99% by weight, preferably from 35% to 95% by weight, and more preferably from 40% to 90% by weight, relative to the total weight of the composition.

[0143] (Fatty Material) The composition according to the present invention may comprise (d) at least fatty material. If two or more fatty materials are used, they may be the same or different.

[0144] The term “fatty material” here means an organic compound that is substantially insoluble in water at ordinary temperature (25°C) and at atmospheric pressure (760 mmHg or 101325 Pa) (with a solubility of less than 5% by weight, preferably less than 3% by weight, more preferably less than 1% by weight, and even more preferably less than 0.1% by weight).

[0145] On the other hand, the (d) fatty material may be soluble in organic solvents under the same temperature and pressure conditions, for instance chloroform, ethanol, benzene, or decamethylcyclopentasiloxane.

[0146] The (d) fatty material may contain, in its structure, a sequence of at least two siloxane groups or at least one hydrocarbon-based chain containing at least 6 carbon atoms. In the scope of the present invention, it should be noted that the (d) fatty material does not comprise any C2- C3oxyalkylene units or any glycerolated units.

[0147] The (d) fatty material may be in the form of a liquid or a solid. Here, “liquid” and “solid” mean that the (d) fatty material is in the form of a liquid or a paste (non-solid), and a solid, respectively, at ambient temperature under atmospheric pressure. The term “solid” here means a substance which is not flowable under its own weight, contrary to the liquid.

[0148] It is preferable that the (d) fatty material be in the form of a liquid or a paste, more preferably in the form of a liquid, at ambient temperature and under atmospheric pressure. Here, the (d) fatty material which is in the form of a liquid at ambient temperature and under atmospheric pressure may be referred to as “oil”.

[0149] The (d) fatty material may be volatile or non-volatile.

[0150] The (d) fatty material may be selected from the group consisting of oils and butters of animal or plant origin, aliphatic hydrocarbons, synthetic glycerides, silicone oils, fatty esters (other than the oils and butters of animal or plant origin), fatty alcohols, fatty acids, and mixtures thereof.

[0151] As examples of oils of animal origin, mention may be made of, for example, squalene, perhydrosqualene, and squalane.

[0152] As examples of oils of plant origin, mention may be made of, for example, linseed oil, camellia oil, macadamia nut oil, sunflower oil, apricot oil, soybean oil, arara oil, hazelnut oil, com oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, grapeseed oil, sesame oil, soybean oil, and peanut oil.

[0153] As examples of butters of plant origin, mention may be made of, for example, shea butter or Butyrospermum parkii butter, Nilotica shea butter, galam butter, Borneo butter or fat or tengkawang tallow (Shorea stenoptera), shorea butter, illipe butter, madhuca butter or (Bassia) Madhuca longifolia butter, mowrah butter (Madhuca latifolia), katiau butter (Madhuca mottleyana), phulwara butter (M. butyracea), mango butter (Mangifera indica), murumuru butter (Astrocaryum murumuru), kokum butter (Garcinia indica), ucuuba butter (Virola sebifera), tucuma butter, painya (kpangnan) butter (Pentadesma butyracea), coffee butter (Coffea arabica), apricot butter (Prunus armeniaca), macadamia butter (Macadamia temifolia), grapeseed butter (Vitis vinifera), avocado butter (Persea gratissima), olive butter (Olea europaea), sweet almond butter (Prunus amygdalus dulcis), cocoa butter (Theobroma cacao), and sunflower butter.

[0154] In one embodiment of the present invention, it is preferable to use shea butter.

[0155] As examples of aliphatic hydrocarbons, mention may be made of, for example, linear or branched hydrocarbons such as mineral oil (e.g., liquid paraffin), paraffin, vaseline or petrolatum, naphthalenes, and the like; hydrogenated polyisobutene, isoeicosan, polydecenes, hydrogenated polyisobutenes such as Parleam, and decene / butene copolymer; and mixtures thereof.

[0156] As examples of other aliphatic hydrocarbons, mention may also be made of linear or branched, or possibly cyclic lower alkanes such as C6-C16, C9-C12and C15-C19alkanes. Examples that may be mentioned include hexane, undecane, dodecane, tridecane, and isoparaffins such as isohexadecane and isodecane.

[0157] As example of synthetic glycerides, mention may be made of, for instance, caprylic / capric acid triglycerides, for instance those sold by the company Stearinerie Dubois or those sold under the names Miglyol® 810, 812 and 818 by the company Dynamit Nobel.

[0158] As examples of silicone oils, mention may be made of, for example, linear organopolysiloxanes such as dimethylpolysiloxanes, methylphenylpolysiloxanes, methylhydrogenpolysiloxanes, and the like; cyclic organopolysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, and the like; and mixtures thereof.

[0159] As examples of fatty esters (esters of a fatty acid and / or of a fatty alcohol) which are different from the oils and butters of animal or plant origin, as well as the synthetic glycerides mentioned above, mention may be made especially of esters of saturated or unsaturated, linear or branched C1-C26aliphatic mono- or polyacids and of saturated or unsaturated, linear or branched C1-C26aliphatic mono- or poly alcohols, the total carbon number of the esters being greater than or equal to 10.

[0160] Among the monoesters, mention may be made of dihydroabietyl behenate; octyldodecyl behenate; isocetyl behenate; cetyl lactate; C12-C15alkyl lactate; isostearyl lactate; lauryl lactate; linoleyl lactate; oleyl lactate; (iso)stearyl octanoate; isocetyl octanoate; octyl octanoate; cetyl octanoate; decyl oleate; isocetyl isostearate; isocetyl laurate; isocetyl stearate; isodecyl octanoate; isodecyl oleate; isononyl isononanoate; isostearyl palmitate; methylacetyl ricinoleate; myristyl stearate; octyl isononanoate; 2-ethylhexyl isononate; octyl palmitate; octyl pelargonate; octyl stearate; octyldodecyl erucate; oleyl erucate; ethyl and isopropyl palmitates, 2-ethylhexyl palmitate, 2-octyldecyl palmitate, alkyl myristates such as isopropyl, butyl, cetyl, 2-octyldodecyl, myristyl, or stearyl myristate, hexyl stearate, butyl stearate, isobutyl stearate; dioctyl malate, hexyl laurate, and 2-hexyldecyl laurate.

[0161] Still within the context of this variant, esters of C4-C22dicarboxylic or tricarboxylic acids and of C1-C22alcohols and esters of mono-, di- or tricarboxylic acids, and of C2-C26di-, tri-, tetra- or pentahydroxy alcohols may also be used. The following may especially be mentioned: diethyl sebacate; diisopropyl sebacate; diisopropyl adipate; di-n-propyl adipate; dioctyl adipate; diisostearyl adipate; dioctyl maleate; glyceryl undecylenate; octyldodecyl stearoyl stearate; pentaerythrityl monoricinoleate; pentaerythrityl tetraisononanoate; pentaerythrityl tetrapelargonate; pentaerythrityl tetraisostearate; pentaerythrityl tetraoctanoate; propylene glycol dicaprylate; propylene glycol dicaprate; tridecyl erucate; triisopropyl citrate; triisostearyl citrate; glyceryl trilactate; glyceryl trioctanoate; trioctyldodecyl citrate; trioleyl citrate; propylene glycol dioctanoate; neopentyl glycol diheptanoate; diethylene glycol diisononanoate; and polyethylene glycol distearates.

[0162] Among the esters mentioned above, it may be preferable to use ethyl, isopropyl, myristyl, cetyl, or stearyl palmitate, 2-ethylhexyl palmitate, 2-octyldecyl palmitate, alkyl myristates such as isopropyl, butyl, cetyl or 2-octyldodecyl myristate, hexyl stearate, butyl stearate, or isobutyl stearate; dioctyl malate, hexyl laurate, 2-hexyldecyl laurate, isononyl isononanoate, or cetyl octanoate.

[0163] The composition according to the present invention may also comprise, as fatty esters, sugar esters and diesters of C6-C30and preferably C12-C22fatty acids. It is recalled that the term “sugar” means oxygen-bearing hydrocarbon-based compounds containing several alcohol functions, with or without aldehyde or ketone functions, and which contain at least 4 carbon atoms. These sugars may be monosaccharides, oligosaccharides, or polysaccharides.

[0164] Examples of suitable sugars that may be mentioned include sucrose (or saccharose), glucose, galactose, ribose, fructose, maltose, mannose, arabinose, xylose, and lactose, and derivatives thereof, especially alkyl derivatives, such as methyl derivatives, for instance methylglucose.

[0165] The sugar esters of fatty acids may be chosen especially from the group comprising the esters or mixtures of esters of sugars described previously and of linear or branched, saturated or unsaturated C6-C30and preferably C12-C22fatty acids. If they are unsaturated, these compounds may comprise one to three conjugated or non-conjugated carbon-carbon double bonds.

[0166] The esters according to this variant may also be chosen from mono-, di-, tri-, tetraesters, and polyesters, and mixtures thereof.

[0167] These esters may be chosen, for example, from oleates, laurates, palmitates, myristates, behenates, cocoates, stearates, linoleates, linolenates, caprates, and arachidonates, or mixtures thereof such as, especially, oleo-palmitate, oleo-stearate and palmito-stearate mixed esters.

[0168] It may be more preferable to use monoesters and diesters and especially sucrose, glucose, or methylglucose mono- or dioleates, stearates, behenates, oleopalmitates, linoleates, linolenates, and oleostearates.

[0169] An example that may be mentioned is the product sold under the name Glucate® DO by the company Amerchol, which is a methylglucose dioleate.

[0170] Examples of esters or mixtures of esters of sugar and of fatty acid that may also be mentioned include: the products sold under the names Crodesta F 160, Fl 40, Fl 10, F90, F70, and SL40 by the company Croda, Inc., respectively denoting sucrose palmitostearates formed from 73% monoester and 27% diester and triester, from 61% monoester and 39% diester, trimester, and tetraester, from 52% monoester and 48% diester, triester, and tetraester, from 45% monoester and 55% diester, triester and tetraester, from 39% monoester and 61% diester, triester, and tetraester, and sucrose monolaurate; the products sold under the name Ryoto Sugar Esters, for example, reference B370 and corresponding to sucrose behenate formed from 20% monoester and 80% di-, tri-, polyester; the sucrose mono-dipalmito-stearate sold by the company Goldschmidt under the name Tegosoft®PSE.

[0171] The (d) fatty material may be at least one fatty acid, and two or more fatty acids may be used.

[0172] The fatty acids should be in acidic form (i.e., unsalified, to avoid soaps) and may be saturated or unsaturated and contain from 6 to 30 carbon atoms and in particular from 9 to 30 carbon atoms, which is optionally substituted, in particular with one or more hydroxyl groups (in particular 1 to 4). If they are unsaturated, these compounds may comprise one to three conjugated or non-conjugated carbon-carbon double bonds. They are more particularly chosen from myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, and isostearic acid.

[0173] The (d) fatty material may be at least one fatty alcohol, and two or more fatty alcohols may be used.

[0174] The term “fatty alcohol” here means any saturated or unsaturated, linear or branched C8-C30fatty alcohol, which is optionally substituted, in particular with one or more hydroxyl groups (in particular 1 to 4). If they are unsaturated, these compounds may comprise one to three conjugated or non-conjugated carbon-carbon double bonds.

[0175] Among the C8-C30fatty alcohols, C12-C22fatty alcohols, for example, may be used. Mention may be made among these of lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, linolenyl alcohol, myristyl alcohol, arachidonyl alcohol, and erucyl alcohol, and mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, or a mixture thereof (e.g., cetearyl alcohol), as well as myristyl alcohol, can be used as a solid fatty material. In another embodiment, isostearyl alcohol can be used as a liquid fatty material.

[0176] In one embodiment of the present invention, the (d) fatty material may be a wax. Here, “wax” means a fatty material which is substantially in the form of a solid at room temperature (25°C) under atmospheric pressure (760 mmHg or 101325 Pa), and has a melting point generally of 35°C or more. As the waxy fatty material, waxes generally used in cosmetics can be used alone or in combinations thereof.

[0177] For example, the wax may be chosen from carnauba wax, microcrystalline waxes, ozokerites, hydrogenated jojoba oil, polyethylene waxes such as the wax sold under the name "Performalene 400 Polyethylene" by the company New Phase Technologies, silicone waxes, for instance poly(C24-C28)alkylmethyldimethylsiloxane, such as the product sold under the name "Abil Wax 9810" by the company Goldschmidt, palm butter, C20-C40 alkyl stearate sold under the name "Kester Wax K82H" by the company Koster Keunen, stearyl benzoate, shellac wax, and mixtures thereof. For example, a wax chosen from carnauba wax, candelilla wax, ozokerites, hydrogenated jojoba oil, and polyethylene waxes may be used. In at least one embodiment, the wax is preferably chosen from candelilla wax and ozokerite, and mixtures thereof. It is preferable that the (d) fatty material be selected from aliphatic hydrocarbons, plant oils, plant butters, and mixtures thereof, and more preferably from aliphatic hydrocarbons, plant butters, and mixtures thereof, and even more preferably from alkanes, shea butter, and mixtures thereof.

[0178] The amount of the (d) fatty material(s) in the composition according to the present invention may be 0.1% by weight or more, preferably 0.5% by weight or more, and more preferably 1% by weight or more, relative to the total weight of the composition.

[0179] On the other hand, the amount of the (d) fatty material(s) in the composition according to the present invention may be 15% by weight or less, preferably 10% by weight or less, and more preferably 5% by weight or less, relative to the total weight of the composition.

[0180] Thus, the amount of the (d) fatty material(s) in the composition according to the present invention may be from 0.1% to 15% by weight, preferably from 0.5% to 10% by weight, and more preferably from 1% to 5% by weight, relative to the total weight of the composition.

[0181] (Surfactant)

[0182] The composition according to the present invention may comprise (e) at least surfactant. If two or more surfactants are used, they may be the same or different.

[0183] The (e) surfactant may be selected from the group consisting of (el) anionic surfactants, (e2) cationic surfactants, (e3) amphoteric surfactants, (e4) nonionic surfactants, and mixtures thereof.

[0184] It is more preferable that the (e) surfactant be selected from (e4) nonionic surfactants.

[0185] The amount of the (e) surfactant(s) in the composition according to the present invention may be 0.01% by weight or more, preferably 0.05% by weight or more, and more preferably 0.1% by weight or more, relative to the total weight of the composition.

[0186] On the other hand, the amount of the (e) surfactant(s) in the composition according to the present invention may be 10% by weight or less, preferably 5% by weight or less, and more preferably 1% by weight or less, relative to the total weight of the composition.

[0187] Thus, the amount of the (e) surfactant(s) in the composition according to the present invention may be from 0.01% to 10% by weight, preferably from 0.05% to 5% by weight, and more preferably from 0.1% to 1% by weight, relative to the total weight of the composition.

[0188] Anionic Surfactant:

[0189] It may be preferable that the (el) anionic surfactant be selected from the group consisting of (C6-C30)alkyl sulfates, (C6-C30)alkyl ether sulfates, (C6-C30)alkylamido ether sulfates, alkylaryl polyether sulfates, monoglyceride sulfates; (C6-C30)alkylsulfonates, (C6- C3o)alkylamide sulfonates, (C6-C30)alkylaryl sulfonates, a-olefin sulfonates, paraffin sulfonates; (C6-C30)alkyl phosphates; (C6-C30)alkyl sulfosuccinates, (C6-C30)alkyl ether sulfosuccinates, (C6-C30)alkylamide sulfosuccinates; (C6-C30)alkyl sulfoacetates; (C6-C24)acyl sarcosinates; (C6-C24)acyl glutamates; (C6-C30)alkylpolyglycoside carboxylic ethers; (C6- C30)alkylpolyglycoside sulfosuccinates; (C6-C30)alkyl sulfosuccinamates; (C6-C24)acyl isethionates; N-(C6-C24)acyl taurates; C6-C30fatty acid salts; coconut oil acid salts or hydrogenated coconut oil acid salts; (C8-C20)acyl lactylates; (C6-C30)alkyl-D-galactoside uronic acid salts; polyoxyalkylenated (C6-C30)alkyl ether carboxylic acid salts; polyoxyalkylenated (C6-C30)alkylaryl ether carboxylic acid salts; and polyoxyalkylenated (C6-C30)alkylamido ether carboxylic acid salts; and corresponding acid forms.

[0190] In at least one embodiment, the (el) anionic surfactants are in the form of salts such as salts of alkali metals, for instance sodium; salts of alkaline-earth metals, for instance magnesium; ammonium salts; amine salts; and amino alcohol salts. Depending on the conditions, they may also be in acid form.

[0191] Cationic Surfactant:

[0192] The (e2) cationic surfactant may be selected from the group consisting of optionally polyoxyalkylenated, primary, secondary or tertiary fatty amine salts, quaternary ammonium salts, and mixtures thereof.

[0193] According to one embodiment, the (e2) cationic surfactant that may be used in the composition according to the present invention is chosen from behenyltrimethylammonium chloride, cetyltrimethylammonium chloride, Quatemium-83, Quatemium-87, Quatemium-22, behenylamidopropyl-2,3-dihydroxypropyldimethylammonium chloride, palmitylamidopropyltrimethylammonium chloride, and stearamidopropyldimethylamine.

[0194] Amphoteric Surfactant:

[0195] The (e3) amphoteric surfactants (zwitterionic surfactants) can be, for example (non-limiting list), amine derivatives such as aliphatic secondary or tertiary amines, and optionally quatemized amine derivatives, in which the aliphatic radical is a linear or branched chain including 8 to 22 carbon atoms and containing at least one water-solubilizing anionic group (for example, carboxylate, sulphonate, sulphate, phosphate or phosphonate).

[0196] The (e3) amphoteric surfactant may preferably be selected from the group consisting of betaines and amidoaminecarboxylated derivatives.

[0197] In one embodiment, the (e3) amphoteric surfactant may be selected from betaine-type surfactants.

[0198] The betaine-type amphoteric surfactant is preferably selected from the group consisting of alkylbetaines, alkylamidoalkylbetaines, sulfobetaines, phosphobetaines, and alkylamidoalkylsulfobetaines, in particular, (C8-C24)alkylbetaines, (C8-C24)alkylamido(C1- C8)alkylbetaines, sulphobetaines, and (C8-C24)alkylamido(C1-C8)alkylsulphobetaines. In one embodiment, the (e3) amphoteric surfactants of betaine type are chosen from (C8- C24)alkylbetaines, (C8-C24)alkylamido(C1-C8)alkylsulphobetaines, sulphobetaines, and phosphobetaines.

[0199] Non-limiting examples that may be mentioned include the compounds classified in the CTFA International Cosmetic Ingredient Dictionary & Handbook, 15th Edition, 2014, under the names cocobetaine, laurylbetaine, cetylbetaine, coco / oleamidopropylbetaine, cocamidopropylbetaine, palmitamidopropylbetaine, stearamidopropylbetaine, cocamidoethylbetaine, cocamidopropylhydroxysultaine, oleamidopropylhydroxysultaine, cocohydroxysultaine, laurylhydroxysultaine, and cocosultaine, alone or as mixtures.

[0200] The betaine-type amphoteric surfactant is preferably an alkylbetaine and an alkylamidoalkylbetaine, in particular cocobetaine and cocamidopropylbetaine.

[0201] (Nonionic Surfactant)

[0202] The (e4) non-ionic surfactants may be chosen from alkyl and polyalkyl esters of polyethylene oxide), alkyl and polyalkyl ethers of poly(ethylene oxide), oxyalkylenated alcohols, optionally polyoxyethylenated alkyl and polyalkyl esters of sorbitan, optionally polyoxyethylenated alkyl and polyalkyl ethers of sorbitan, alkyl and polyalkyl glycosides or polyglycosides, in particular alkyl and polyalkyl glucosides or polyglucosides, alkyl and polyalkyl esters of sucrose, optionally polyoxyethylenated alkyl and polyalkyl esters of glycerol, and optionally polyoxyethylenated alkyl and polyalkyl ethers of glycerol, and mixtures thereof.

[0203] In one embodiment, the (e4) nonionic surfactant may be selected from polyglyceryl fatty acid esters.

[0204] The polyglyceryl fatty acid ester may have a polyglycerol moiety derived from 2 to 10 glycerols, preferably from 2 to 8 glycerols, and more preferably 2 to 6 glycerols. In other words, the polyglyceryl fatty acid ester may comprise from 2 to 10 polyglyceryl units, preferably 2 to 8 polyglyceryl units, and more preferably 2 to 6 polyglyceryl units.

[0205] The polyglyceryl fatty acid ester may be chosen from the mono, di and tri esters of a linear or branched, saturated or unsaturated fatty acid, preferably saturated fatty acid, including from 4 to 32 carbon atoms, preferably from 8 to 26 carbon atoms, and more preferably from 10 to 20 carbon atoms, such as lauric acid, oleic acid, stearic acid, isostearic acid, capric acid, caprylic acid, and myristic acid.

[0206] It is preferable that the (c4) nonionic surfactant be selected form polyglyceryl saturated or unsaturated fatty acid monoesters.

[0207] The polyglyceryl fatty acid ester may have an HLB (Hydrophilic Lipophilic Balance) value of from 7.0 to 16.0, preferably from 7.5 to 15.5, and more preferably from 8.0 to 15.0. The term HLB ("hydrophilic-lipophilic balance") is well known to those skilled in the art, and reflects the ratio between the hydrophilic part and the lipophilic part in the molecule. If two or more polyglyceryl fatty acid esters are used, the HLB value is determined by the weighted average of the HLB values of all the polyglyceryl fatty acid esters.

[0208] The polyglyceryl fatty acid ester may be selected from the group consisting of PG-2 caprate (HLB: 9.5), PG-2 laurate (HLB: 8.5), PG-4 oleate (HLB: 8.8), PG-4 laurate (HLB: 10.4), PG- 4 isostearate (HLB: 8.2), PG-5 laurate (HLB: 15.8), PG-6 isostearate (HLB: 10.8), PG-3 cocoate (HLB: 12.0), PG-3 caprate (HLB: 10.0), PG-4 caprylate (HLB: 14), PG-4 caprate (HLB: 14.0), PG-5 myristate (HLB: 15.4), PG-5 stearate (HLB: 15.0), PG-5 oleate (HLB: 14.9), PG-6 caprylate (HLB: 14.6), PG-6 caprate (HLB: 13.1), PG-6 laurate (HLB: 14.5), and mixtures thereof. It may be preferable that the (e4) nonionic surfactant be selected from polyglyceryl fatty acid esters, more preferably polyglyceryl saturated fatty acid esters, and even more preferably polyglyceryl saturated fatty acid monoesters such as PG-4 caprate.

[0209] (pH)

[0210] The pH of the aqueous phase of the composition according to the present invention may be from 3 to 7, preferably from 4 to 6.5, and more preferably from 5 to 6.

[0211] The pH of the composition according to the present invention may be adjusted by adding at least one alkaline agent and / or at least one acid.

[0212] The pH of the composition according to the present invention may also be adjusted by adding at least one buffering agent.

[0213] Alkaline Agent:

[0214] The composition according to the present invention may comprise at least one alkaline agent. Two or more alkaline agents may be used in combination. Thus, a single type of alkaline agent or a combination of different types of alkaline agents may be used.

[0215] The alkaline agent may be an inorganic alkaline agent. It is preferable that the inorganic alkaline agent be selected from the group consisting of ammonia; alkaline metal hydroxides; alkaline earth metal hydroxides; alkaline metal phosphates and monohydrogenophosphates such as sodium phosphate or sodium monohydrogen phosphate.

[0216] As examples of the inorganic alkaline metal hydroxides, mention may be made of sodium hydroxide and potassium hydroxide. As examples of the alkaline earth metal hydroxides, mention may be made of calcium hydroxide and magnesium hydroxide. As an inorganic alkaline agent, sodium hydroxide is preferable.

[0217] The alkaline agent may be an organic alkaline agent. It is preferable that the organic alkaline agent be selected from the group consisting of monoamines and derivatives thereof; diamines and derivatives thereof; polyamines and derivatives thereof; basic amino acids and derivatives thereof; oligomers of basic amino acids and derivatives thereof; polymers of basic amino acids and derivatives thereof; urea and derivatives thereof; and guanidine and derivatives thereof.

[0218] As examples of the organic alkaline agents, mention may be made of alkanolamines such as mono-, di- and tri-ethanolamine, and isopropanolamine; urea, guanidine and their derivatives; basic amino acids such as ornithine; and diamines such as those described in the structure below: wherein

[0219] R denotes an alkylene such as propylene optionally substituted by a hydroxyl or a C1-C4alkyl radical, and R1, R2, R3and R4independently denote a hydrogen atom, an alkyl radical or a C1- C4hydroxyalkyl radical, which may be exemplified by 1,3-propanediamine and derivatives thereof.

[0220] The alkaline agent(s) may be used in a total amount of from 0.01% to 15% by weight, preferably from 0.02% to 10% by weight, more preferably from 0.03% to 5% by weight, relative to the total weight of the composition, depending on their solubility.

[0221] Acid:

[0222] The composition according to the present invention may comprise at least one acid. Two or more acids may be used in combination. Thus, a single type of acid or a combination of different types of acids may be used.

[0223] As the acid, mention may be made of any inorganic or organic acids, preferably inorganic acids, which are commonly used in cosmetic products. A monovalent acid and / or a polyvalent acid may be used. A monovalent acid such as citric acid, lactic acid, sulfuric acid, phosphoric acid and hydrochloric acid (HC1) may be used. Lactic acid may be preferable.

[0224] The acid(s) may be used in a total amount of from 0.01% to 15% by weight, preferably from 0.02% to 10% by weight, more preferably from 0.03% to 5% by weight, relative to the total weight of the composition, depending on their solubility.

[0225] (Other Optional Additives)

[0226] The composition according to the present invention may also comprise any other optional additive(s) usually used in the field of cosmetics, chosen, for example, from solvents, thickeners, fillers, UV filters, fatty acids, cosmetic active agents other than ingredient (a), preservatives, and mixtures thereof.

[0227] It is a matter of routine operations for a person skilled in the art to adjust the nature and amount of the above optional additives which may be present in the composition in accordance with the present invention such that the desired cosmetic properties are not thereby affected.

[0228] As the solvents, mention may be made of one or several cosmetically acceptable organic solvents, which may be alcohols: in particular monovalent alcohols such as ethyl alcohol, isopropyl alcohol, benzyl alcohol, and phenylethyl alcohol; diols such as ethylene glycol, propylene glycol, and butylene glycol; other polyols such as glycerol, sugar, and sugar alcohols; and ethers such as ethylene glycol monomethyl, monoethyl, and monobutyl ethers, propylene glycol monomethyl, monoethyl, and monobutyl ether, and butylene glycol monomethyl, monoethyl, and monobutyl ethers.

[0229] The organic solvent(s) may be present in a concentration of from 0.01% to 30% by weight, preferably from 0.05% to 20% by weight, and more preferably from 0.1% to 10% by weight, relative to the total weight of the composition.

[0230] (Preparation) The composition according to the present invention can be prepared by mixing the abovedescribed essential and optional ingredients in a conventional manner.

[0231] For example, the composition according to the present invention can be prepared by a process comprising the steps of mixing

[0232] (a) at least one first compound explained above; and

[0233] (b) at least one second compound explained above.

[0234] It is possible to further mix any of the optional ingredients.

[0235] The mixing can be performed at any temperature such as room temperature (e.g., 20-25°C, preferably at 25°C), preferably at a temperature of 30°C or more, preferably 40°C or more, and more preferably 50°C or more. It is preferable to further mix with any of the abovedescribed optional ingredients such as a pH adjusting agent.

[0236] The form of the composition according to the present invention is not particularly limited, and may take various forms such as a W / O emulsion, an O / W emulsion, a gel, a solution, or the like. It is preferable that the composition according to the present invention be in the form of an emulsion, preferably an O / W emulsion, and more preferably an O / W gel emulsion.

[0237] [Cosmetic Process]

[0238] The composition according to the present invention may be used as a cosmetic or dermatologic composition, preferably a cosmetic composition, and more preferably a cosmetic composition for a keratin material. As the keratin material, mention may be made of skin, scalp, hair, mucosa such as lips, and nails. It is even more preferable that the composition according to the present invention be a skin cosmetic composition.

[0239] The composition according to the present invention may be used as a depigmenting, bleaching or whitening product for a keratin material such as skin. In particular, the composition according to the present invention may be used as a whitening product.

[0240] The composition according to the present invention may preferably be intended for application onto a keratin material such as skin, scalp and / or lips, preferably skin.

[0241] Thus, the composition according to the present invention can be used for a cosmetic process for a keratin material, preferably skin. In one embodiment, the present invention relates to a cosmetic process, preferably a whitening process, for a keratin material, preferably skin, comprising the step of applying onto the keratin material the composition according to the present invention.

[0242] The composition according to the present invention can be used as a topical cosmetic composition in the form of a lotion, a milky lotion, a cream, a gel, a paste, a serum, a foam, or a spray.

[0243] [Use]

[0244] The present invention also relates to a use of (b) at least one second compound selected from ergothioneine and derivatives thereof in a composition comprising (a) at least one first compound selected from compounds of formula (I) below, tautomers of formula (I') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof: in which

[0245] Ri denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, and

[0246] R2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals wherein

[0247] R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group in order to stabilize the (a) first compound(s).

[0248] The term “stabilize” has the same meaning as enhancing stability.

[0249] The use according to the present invention can increase the stability of the (a) first compound in the composition comprising the same.

[0250] Therefore, the use according to the present invention can make it possible to store a composition comprising the (a) first compound for a long period of time, and in particular even under hot conditions.

[0251] The above explanations regarding the (a) first compound and the (b) second compound for the compositions according to the present invention can also apply to those used in the use according to the present invention. The composition in the use according to the present invention may include any of the optional ingredients as explained above for the compositions according to the present invention.

[0252] EXAMPLES

[0253] The present invention will be described in a more detailed manner by way of examples. However, these examples should not be construed as limiting the scope of the present invention.

[0254] Example 1 and Comparative Examples 1-6

[0255] [Preparation] Each of the compositions according to Example 1 and Comparative Examples 1-6 was prepared by mixing the ingredients shown in Table 1. The numerical values for the amounts of the ingredients are all based on “% by weight” as active materials.

[0256]

[0257] 2-Mercaptonicotinoyl Glycine: N-[(2-thioxo- 1 ,2-dihydropyridin-3-yl)carbonyl]glycine (Compound 20)

[0258] [Evaluations]

[0259] (Thiopyridinone Compound Remaining Rate)

[0260] 1.0 g each of the compositions according to Example 1 and Comparative Examples 1-6 was mixed with 50 mL of water to prepare an aqueous solution of the composition. Methanol was added to the aqueous solution of the composition and was subjected to sonication followed by stirring for about 1.5 hours. The resulting solution was filtered.

[0261] A portion of the filtered solution was subjected to HPLC-UV analysis to determine the amount of the thiopyridinone compound (2-Mercaptonicotinoyl Glycine) at the following Timing (1).

[0262] Another portion of the filtered solution was placed in a sealed and light-shielding container at 55°C for 2 weeks, and subjected to HPLC-UV analysis to determine the amount of the thiopyridinone compound (2-Mercaptonicotinoyl Glycine) at the following Timing (2).

[0263] Another portion of the filtered solution was placed in a sealed and light-shielding container at 45°C for 2 months, and subjected to HPLC-UV analysis to determine the amount of the thiopyridinone compound (2-Mercaptonicotinoyl Glycine) at the following Timing (3).

[0264] Timing (1) Just after the preparation (T0)

[0265] Timing (2) 2 weeks after the preparation (T2W)

[0266] Timing (3) 2 months after the preparation (T2M)

[0267] The details of the HPLC-UV assay are as follows.

[0268] Apparatus / Reagents

[0269] HPLC Conditions

[0270] The thiopyridinone compound remaining rate was determined by the following equation:

[0271] T2W Thiopyridinone Compound Remaining Rate (%) = Amount of Thiopyridinone Compound at Timing (2) / Amount of Thiopyridinone Compound at Timing (1)

[0272] T2M Thiopyridinone Compound Remaining Rate (%) =

[0273] Amount of Thiopyridinone Compound at Timing (3) / Amount of Thiopyridinone Compound at Timing (1)

[0274] The results are shown in the “T2W Thiopyridinone Compound Remaining Rate (%)” and “T2M Thiopyridinone Compound Remaining Rate (%)” lines in Table 2 below.

[0275] Table 2

[0276] (Results)

[0277] The composition according to Example 1 which included ergothioneine was stable, even under elevated temperature, for a long period of time, such that a greater amount of the thiopyridinone compound remained, than the compositions according to Comparative Examples 1 -6 which did not include ergothioneine or included an amino acid (serine, aspartic acid, or histidine), an amino acid peptide (carnosine) or an amino acid analogue (taurine), which is different from ergothioneine.

Claims

CLAIMS1. A composition, preferably a cosmetic composition, and more preferably a skin cosmetic composition, comprising(a) at least one first compound selected from compounds of formula (I) below, tautomers of formula (I') below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof:in whichR1denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, andR2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals whereinR3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group; and(b) at least one second compound selected from ergothioneine and derivatives thereof.

2. The composition according to Claim 1, wherein:R1of formula (I) and (I') represents a hydrogen atom; orR1of formula (I) and (T) represents a linear (C1-C10) alkyl group or a branched (C3- C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkylgroup, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably ethyl, particularly the said alkyl group of Ri is not substituted.

3. The composition according to Claim 1 or 2, wherein:R2of formula (I) and (I') represents a hydrogen atom; orR2of formula (I) and (T) represents a linear (C1-C10) alkyl group or a branched (C3- C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl group; the said alkyl group of R2being not substituted.

4. The composition according to Claim 1 or 2, wherein:R2of formula (I) and (I') represents a linear (C1-C10) alkyl group or a branched (C3- C10) alkyl group, especially a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl; the said alkyl group being substituted by one or more groups selected from i), ii), iii) and iv) as defined above, preferably the said alkyl group being substituted by one or two groups selected from i), ii) and iii), more preferably by one or two groups selected from i) and iii), better substituted by one group iii) as carboxy.

5. The composition according to Claim 1 or 2, wherein:R2of formula (I) and (I') represents a (C3-C8) cycloalkyl group, preferably a (C5-C7) cycloalkyl group such cyclohexyl; orR2of formula (I) and (I') represents a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals, preferably a phenyl group particularly not substituted.

6. The composition according to any one of Claims 1 to 5, wherein:R3of formula (I) and (I') represents a hydrogen atom; orR3of formula (I) and (T) represents a saturated, linear C1-C10or branched C3-C10alkyl group; particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably a (C1-C4) alkyl group such as methyl group.

7. The composition according to any one of Claims 1 to 6, wherein: Ri of formula (I) and (I') represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C6or branched C3-C6alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, preferably optionally substituted with one or more groups i);R2of formula (I) and (T) represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10or cyclic C3-C8such as C5- C6hydrocarbonated group, optionally substituted with one or more groups, which may be identical or different, chosen fromi) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a phenyl group optionally substituted with one or more hydroxyls and / or with one or more C1-C4alkoxy radicals such as methoxy, preferably substituted with one or more groups selected from i) and iii), preferably iii) such as carboxy; andR3of formula (I) and (I') represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C6or branched C3-C6alkyl group, preferentially, the compounds of formula (I) and tautomer (I'), salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof, have the following meanings:R1of formula (I) and (I') represents a radical chosen from: a) a hydrogen atom, and b) a saturated, linear C1-C4or branched C3-C4alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -OR3, more preferably not substituted;R2of formula (I) and (I') represents a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10or cyclic C3-C8such as C5- C6hydrocarbonated group, optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C4alkoxy radicals; andR3of formula (I) and (I') represents a radical chosen from: a) a hydrogen atom; b) a saturated, linear C1-C4or branched C3-C4alkyl group such as methyl or ethyl.

8. The composition according to any one of Claims 1 to 7, wherein: the (a) first compound is selected from the compounds 1 to 24 below, tautomers thereof, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof, particularly the compounds 1, 2, 4, 6, 7, 9, 11, 12, 14, 15, 16, 17, 18, 19, 20, or 21, more particularly 1, 9, 16, 18, 19, 20, or 21, preferably 18, 19, 20, or 21, and more preferably 20:

9. The composition according to any one of Claims 1 to 8, wherein the amount of the (a) first compound(s) in the composition is from 0.001% to 10% by weight, preferably from 0.005% to 5% by weight, and more preferably from 0.01% to 3% by weight, relative to the total weight of the composition.

10. The composition according to any one of Claims 1 to 9, wherein the (b) second compound is represented by the following chemical formula (II): in which:X represents a group -O-R', -O-M or -NR'R";R, R' and R" represent, simultaneously or independently of each other, a hydrogen atom, an alkyl, alkenyl or acyl group of C1-C18, the alkyl, alkenyl or acyl group being linear or branched, optionally substituted with at least one substituent selected from hydroxyl group, possibly being esterified, halogen atoms, carboxylic group and its derivatives, and amine group and its derivatives, and possibly containing in the chain at least one hetero atom such as O and S; and M represents a cation such as a metal cation.

11. The composition according to Claim 10, in which the groups R, R' and R" of the chemical formula (II) denote, simultaneously or independently of each other, a hydrogen atom or an ethyl, acetyl or acyl group, and preferably R denotes a hydrogen atom or an ethyl, acetyl or acyl group, and X denotes NH2.

12. The composition according to Claim 10 or 11, in which the (b) second compound is ergothioneine.

13. The composition according to any one of Claims 1 to 11, wherein the amount of the (b) second compound(s) in the composition is from 0.001% to 15% by weight, preferably from 0.005% to 10% by weight, more preferably from 0.01% to 5% by weight, relative to the total weight of the composition.

14. A cosmetic process, preferably a whitening process, for a keratin material, preferably skin, comprising the step of: applying to the keratin material the composition according to any one of Claims 1 to 13.

15. Use of (b) at least one second compound selected from ergothioneine and derivatives thereof in a composition comprising (a) at least one first compound selected from compounds of formula (I) below, tautomers of formula (T) below, salts thereof, solvates thereof such as hydrates, optical isomers thereof, racemates thereof, and mixtures thereof:in whichR1denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, and ii) -S-R3, andR2denotes a radical chosen from a) a hydrogen atom, b) a saturated, linear C1-C12or branched C3-C12or cyclic C3-C8hydrocarbonated group optionally substituted with one or more groups, which may be identical or different, chosen from i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C12aryl group optionally substituted with one or morehydroxyls and / or with one or more C1-C8alkoxy radicals, and c) a C5-C12aryl group optionally substituted with one or more hydroxyls and / or with one or more C1-C8alkoxy radicals wherein R3denotes a radical chosen from a) a hydrogen atom, and b) a saturated, linear C1-C10or branched C3-C10alkyl group in order to stabilize the (a) first compound(s).

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