Thiadiazine compounds and uses thereof

Abstract

Provided herein are thiadiazine dione compounds, e.g., for modulating muscle myosin to treat obesity and related disorders such as cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, cancer, and osteoarthritis.

Description

THIADIAZINE COMPOUNDS AND USES THEREOFCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application No. 63 / 702563, filed on October 2, 2024, which is hereby incorporated by reference in its entirety.BACKGROUND OF THE INVENTION

[0002] Obesity is a medical condition involving excess body fat accumulated to such an extent that it can potentially have negative effects on health. Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. In 2022, over 1 billion people were obese worldwide. Excess body fat underlies 64% of cases of diabetes in men and 77% of cases in women.SUMMARY OF THE INVENTION

[0003] The disclosure provides compound and salts thereof for use in treating disease. In certain aspects, the disclosure provides a compounds and salts of Formula (I), pharmaceutical compositions thereof, as well as methods of use in the treatment of disease.

[0004] Disclosed herein is a method of treating metabolic disease, diabetes, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the method comprising administering a therapeutically effective amount of a compound of Formula (I).INCORPORATION BY REFERENCE

[0005] All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.DETAILED DESCRIPTION OF THE INVENTION

[0006] In certain aspects, the disclosure provides methods for treating metabolic disease, diabetes, a neuromuscular condition, a skeletal muscular condition, sarcopenia, muscle wasting, muscle spasm, inducing weight loss, or of inducing muscle gain in an individual in need thereof, the method comprising administering a therapeutically effective amount of a compound of Formula (I).Definitions

[0007] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in the art to which this invention belongs.

[0008] As used in the specification and claims, the singular form “a”, “an” and “the” includes pluralreferences unless the context clearly dictates otherwise.

[0009] The term “Cx-y” or “Cx-Cy” (e.g., when used in conjunction with a chemical moiety, such asalkyl, alkenyl, or alkynyl) is meant to include groups that comprise a number of carbon atoms greater than or equal to x carbon atoms and less than or equal to y carbon atoms in the chemical moiety, subject to the following. The term “Cx-y” or “Cx-Cy” is not meant to limit the number of carbon atoms which may be attached to the chemical moiety when the chemical moiety is substituted with a second chemical moiety. For example, the term “C1-6 alkyl” or “C1 to C6 alkyl” refers to saturated, substituted or unsubstituted, hydrocarbon groups, including straight-chain alkyl groups (e.g., linear alkyl groups) and branched alkyl groups that contain 1, 2, 3, 4, 5, or 6 carbon atoms, plus however many carbon atoms may be present in any substituents of the C1-6alkyl. For example, if a C1-6alkyl is optionally substituted with a second chemical moiety comprising two carbon atoms, then it will be understood that the C1-6 alkyl can include between 1 and 8 carbon atoms.

[0010] The terms “Cx-yalkenyl” and “Cx-yalkynyl” refer to substituted or unsubstituted unsaturatedaliphatic groups analogous in length and possible substitution to the alkyls described above, but that contain at least one double or triple bond, respectively.

[0011] "Amino" refers to the –NH2 moiety.

[0012] "Cyano" refers to the -CN moiety.

[0013] "Nitro" refers to the -NO2 moiety.

[0014] "Oxa" refers to the -O- moiety.

[0015] "Oxo" refers to the =O moiety.

[0016] "Thioxo" refers to the =S moiety.

[0017] "Imino" refers to the =N-H moiety.

[0018] "Oximo" refers to the =N-OH moiety.

[0019] "Hydrazino" refers to the =N-NH2 moiety.

[0020] "Alkyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moietyconsisting solely of carbon and hydrogen atoms, fully saturated. In certain embodiments, “alkyl” comprises one to fifteen carbon atoms (e.g., C1-C15 alkyl). In certain embodiments, an alkyl comprises one to thirteen carbon atoms (e.g., C1-C13 alkyl). In certain embodiments, an alkyl comprises one to eight carbon atoms (e.g., C1-C8alkyl). In certain embodiments, an alkyl comprises one to six carbon atoms (e.g., C1-C6alkyl). In other embodiments, an alkyl comprises one to five carbon atoms (e.g., C1-C5 alkyl). In other embodiments, an alkyl comprises one to four carbon atoms (e.g., C1-C4 alkyl). In other embodiments, an alkyl comprises one to three carbon atoms (e.g., C1-C3 alkyl). In other embodiments, an alkyl comprises one to two carbon atoms (e.g., C1-C2alkyl). Inother embodiments, an alkyl comprises one carbon atom (e.g., C1alkyl, e.g., methyl). In other embodiments, an alkyl comprises five to fifteen carbon atoms (e.g., C5-C15 alkyl). In other embodiments, an alkyl comprises five to eight carbon atoms (e.g., C5-C8 alkyl). In other embodiments, an alkyl comprises two to five carbon atoms (e.g., C2-C5alkyl). In other embodiments, an alkyl comprises three to five carbon atoms (e.g., C3-C5 alkyl). In other embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl (n-propyl), 1-methylethyl (2-propyl, iso-propyl), 1- butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), and 1-pentyl (n-pentyl). The alkyl is attached to the rest of the molecule by a single bond.

[0021] “Aminoalkyl” refers to a moiety boded through a nitrogen atom of the form –N(H)(alkyl) orN(alkyl)(alkyl), wherein when the moiety is N(alkyl)(alkyl), the two alkyl groups bonded to nitrogen can be the same alkyl groups or different alkyl groups.

[0022] "Alkoxy" refers to a moiety bonded through an oxygen atom of the formula –O-alkyl, wherealkyl is an alkyl chain as defined above.

[0023] "Alkenyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moietyconsisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon double bond. In certain embodiments, an alkenyl comprises two to twelve carbon atoms. In certain embodiments, an alkenyl comprises two to eight carbon atoms. In other embodiments, an alkenyl comprises two to four carbon atoms.The alkenyl is attached to the rest of the molecule by a single bond, for example, ethenyl (e.g., vinyl), prop-1-enyl (e.g., allyl), but-1-enyl, pent-1-enyl, penta-1,4-dienyl, and the like.

[0024] "Alkynyl" refers to a straight (e.g., linear) or branched (e.g., nonlinear) hydrocarbon moietyconsisting solely of carbon and hydrogen atoms, the moiety comprising at least one carbon-carbon triple bond. In some embodiments, an alkynyl comprises from two to twelve carbon atoms. In some embodiments, an alkynyl optionally further comprises at least one carbon-carbon double bond. In certain embodiments, an alkynyl comprises two to eight carbon atoms. In other embodiments, an alkynyl comprises two to six carbon atoms. In other embodiments, an alkynyl comprises two to four carbon atoms.The alkynyl is attached to the rest of the molecule by a single bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like.

[0025] “Alkylene” or “alkylene chain” refers to a linear (e.g., straight), or branched (e.g., nonlinear),divalent, hydrocarbon moiety. An “alkylene” or “alkylene chain” can link a portion of the molecule to a second moiety. An “alkylene” or “alkylene chain” consists solely of carbon and hydrogen atoms (substitution of an alkylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkylene” or “alkylene chain” can contain nounsaturation (notwithstanding the points of attachment of an alkylene to the rest of the molecule). In certain embodiments, the “alkylene” or “alkylene chain” and comprises one to twelve carbon atoms, for example, methylene, ethylene, propylene, n-butylene, and the like.The alkylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond.The points of attachment of an alkylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkylene chain or can be through any two carbon atoms within the alkylene. In certain embodiments, an alkylene comprises one to eight carbon atoms (e.g., C1-C8 alkylene). In other embodiments, an alkylene comprises one to five carbon atoms (e.g., C1-C5 alkylene). In other embodiments, an alkylene comprises one to four carbon atoms (e.g., C1-C4alkylene). In other embodiments, an alkylene comprises one to three carbon atoms (e.g., C1-C3alkylene). In other embodiments, an alkylene comprises one to two carbon atoms (e.g., C1-C2alkylene). In other embodiments, an alkylene comprises one carbon atom (e.g., C1 alkylene). In other embodiments, an alkylene comprises five to eight carbon atoms (e.g., C5-C8 alkylene). In other embodiments, an alkylene comprises two to five carbon atoms (e.g., C2-C5alkylene). In other embodiments, an alkylene comprises three to five carbon atoms (e.g., C3-C5 alkylene).

[0026] "Alkenylene" or "alkenylene chain" refers to a linear (e.g., straight), or branched, divalent,hydrocarbon moiety. An "alkenylene" or "alkenylene chain" can link a portion of the molecule to a second moiety. An "alkenylene" or "alkenylene chain" consists solely of carbon and hydrogen atoms (substitution of an alkenylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An "alkenylene" or "alkenylene chain" comprises at least one carbon-carbon double bond. In certain embodiments, an "alkenylene" or "alkenylene chain" comprises from two to twelve carbon atoms. The alkenylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkenylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkenylene chain or through any two carbon atoms within the alkenylene chain. In certain embodiments, an alkenylene comprises two to eight carbon atoms (e.g., C2-C8alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g., C2-C5 alkenylene). In other embodiments, an alkenylene comprises two to four carbon atoms (e.g., C2-C4 alkenylene). In other embodiments, an alkenylene comprises two to three carbon atoms (e.g., C2-C3alkenylene). In other embodiments, an alkenylene comprises five to eight carbon atoms (e.g., C5-C8alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g., C2-C5 alkenylene). In other embodiments, an alkenylene comprises three to five carbon atoms (e.g., C3-C5 alkenylene).

[0027] "Alkynylene" or "alkynylene chain" refers to a linear (e.g., straight), or branched, divalent,hydrocarbon moiety. An “alkynylene" or "alkynylene chain" can link a portion of the molecule to a second moiety. An “alkynylene" or "alkynylene chain" consists solely of carbon and hydrogen (substitution of an alkynylene with one or more substituents comprising atoms other than hydrogen, such as N, O, and S, may be specified). An “alkynylene" or "alkynylene chain" comprises at least one carbon-carbon triple bond. In certain embodiments, an “alkynylene" or "alkynylene chain" comprises from two to twelve carbon atoms. An alkynylene chain can be attached to the portion of the molecule through a single bond and to the second moiety through a single bond. The points of attachment of an alkynylene chain to the rest of the molecule and to the second moiety can be through one carbon atom in the alkynylene chain or through any two carbon atoms within the alkynylene chain. In certain embodiments, an alkynylene comprises two to eight carbon atoms (e.g., C2-C8 alkynylene). In other embodiments, an alkynylene comprises two to five carbon atoms (e.g., C2-C5 alkynylene). In other embodiments, an alkynylene comprises two to four carbon atoms (e.g., C2-C4alkynylene). In other embodiments, an alkynylene comprises two to three carbon atoms (e.g., C2-C3 alkynylene). In other embodiments, an alkynylene comprises two carbon atoms (e.g., C2 alkynylene). In other embodiments, an alkynylene comprises five to eight carbon atoms (e.g., C5-C8 alkynylene). In other embodiments, an alkynylene comprises three to five carbon atoms (e.g., C3-C5alkynylene).

[0028] The term “carbocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic ornonaromatic unsaturated) ring or ring system in which each atom of the ring is carbon. The term “carbocycle” comprises “aryls,” “cycloalkenyls,” and “cycloalkyls.” For example, the term “carbocycle” includes 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 5- to 15-membered spiro polycyclic ring systems, 5- to 15-membered bridged polycyclic ring systems, or 4- to 15-membered fused polycyclic ring systems). For example, carbocycle includes 4- to 15-membered bicyclic rings (e.g., 5- to 15- membered spiro bicycles, 5- to 15-membered bridged bicyclic ring systems, or 4- to 15-membered fused bicyclic ring systems). For example, carbocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes tetracyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, carbocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic carbocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. In an exemplary embodiment, an aromatic ring (e.g., phenyl) of a polycyclic carbocycle may be fused to a saturated or unsaturated ring (e.g., cyclohexane,cyclopentane, cyclohexene, or phenyl). A polycyclic carbocycle includes any combination of saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated)rings, as valence permits. For example, polycyclic carbocycles can be spiro bicyclic rings, such as spiropentane. For example, a polycyclic carbocycle includes any combination of ring sizes such as 2-2 spiro ring systems (e.g., spiro[2.2]pentane), 3-3 spiro ring systems, 4-4 spiro ring systems, 4-5 fused ring systems (e.g., bicyclo[4.5.0] fused ring systems), 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems (e.g., naphthalene), 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. Exemplary carbocycles include cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, indanyl, naphthyl, trans-bicyclo[4.4.0]decane, cis-bicylo[4.4.0]decane, spiro[3.4]octane, fluoranthene, and bicyclo[1.1.1]pentanyl. In some embodiments, a carbocycle is bridged, fused, spiro, or any combination thereof. In some embodiments, a carbocycle is a bridged carbocycle. In some embodiments, a carbocycle is a fused carbocycle. In some embodiments, a carbocycle is a spiro carbocycle. In some embodiments, a carbocycle is a bridged and fused carbocycle. In some embodiments, a carbocycle is a bridged and spiro carbocycle. In some embodiments, a carbocycle is a fused and spiro carbocycle. In some embodiments, a carbocycle is a bridged, fused and spiro carbocycle.

[0029] The term “aryl” refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ringsystem comprising at least one cyclic, delocalized (4n+2) π-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Hückel theory. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises only hydrogen atoms and carbon atoms. In some embodiments, the aromatic monocyclic or polycyclic system contains from three to twenty carbon atoms. In some embodiments, at least one of the rings in the polycyclic aromatic ring system is aromatic. In some embodiments, the aromatic monocyclic or aromatic polycyclic hydrocarbon ring system comprises a cyclic, delocalized (4n+2) π-electronic system in accordance with Hückel theory. In some embodiments, the ring system from which aryl groups are derived include, but are not limited to, groups such as benzene, fluorene, indane, indene, anthracene, tetralin, and naphthalene. In some embodiments, the aryl substituent is not charged (e.g., neutral). In some embodiments, the aryl substituent bears no charges. In some embodiments, the aryl substituent bears no net charge. In some embodiments, the aryl substituent bears no net charge and is not zwitterionic. In some embodiments, none of the carbon atoms of the aryl substituent are charged. In some embodiments, none of the carbon atoms of the aryl substituent are charged.

[0030] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon.Cycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 5- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, and 5- to 12-memberedbridged rings. In certain embodiments, a cycloalkyl comprises three to ten carbon atoms. In other embodiments, a cycloalkyl comprises three to seven carbon atoms. In other embodiments, a cycloalkyl comprises five to seven carbon atoms. The cycloalkyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkyls include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Examples of polycyclic cycloalkyls include, but are not limited to, adamantyl, spiropentane, norbornyl (e.g., bicyclo[2.2.1]heptanyl), decalinyl, 7,7 dimethyl bicyclo[2.2.1]heptanyl, bicyclo[1.1.1]pentanyl, spiropentane, and the like.

[0031] The term "cycloalkenyl" refers to a saturated ring in which each atom of the ring is carbonand there is at least one double bond between two ring carbon atoms. Cycloalkenyl may include monocyclic and polycyclic rings, such as 3- to 10-membered monocyclic rings and 4- to 12- membered bicyclic rings (e.g., 5- to 12-membered bridged bicyclic rings, fused 4- to 12-membered bicyclic rings, and spiro 5- to 12-membered bicyclic rings). In other embodiments, a cycloalkenyl comprises five to seven carbon atoms. The cycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl.

[0032] The term “halo” or, alternatively, “halogen” or “halide,” means fluoro, chloro, bromo or iodo.In some embodiments, a halo is fluoro, chloro, or bromo. In some embodiments, a halo is a fluoro or a chloro. In some embodiments, a halo is a fluoro. In some embodiments, a halo is a chloro.

[0033] The term “haloalkyl” refers to an alkyl, as defined above, that is substituted by one or morehalogens, for example, trifluoromethyl, dichloromethyl, bromomethyl, 2,2,2-trifluoroethyl,1-chloromethyl-2-fluoroethyl, and the like. In some embodiments, the alkyl part of the haloalkyl is optionally further substituted as described herein.

[0034] The term “heterocycle” as used herein refers to a saturated or unsaturated (e.g., aromatic ornonaromatic unsaturated) ring or ring system in which one or more heteroatom(s) is(are) member(s) of the ring or ring system. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. For example, heterocycles include 3- to 12-membered monocyclic rings (e.g., 3- to 10- membered monocyclic rings) and 4- to 20-membered polycyclic ring systems (e.g., 4- to 15-membered fused poly ring systems, 5- to 15-membered spiro polycyclic ring systems, and 5- to 15-membered bridged polycyclic ring systems). In some embodiments, a heterocycle is bridged, fused, spiro, or any combination thereof. In some embodiments, a heterocycle is a bridged heterocycle. In some embodiments, a heterocycle is a fused heterocycle. In some embodiments, a heterocycle is a spiro heterocycle. In some embodiments, a heterocycle is a bridged and fused heterocycle. In some embodiments, a heterocycle is a bridged and spiro heterocycle. In some embodiments, a heterocycle is a fused and spiro heterocycle. In some embodiments, a heterocycle is a bridged, fused and spiroheterocycle. For example, heterocycles include 4- to 20-membered bicyclic ring systems (e.g., 4- to 15-membered fused bicyclic ring systems, 5- to 15-membered spiro bicyclic ring systems, and 5- to 15-membered bridged bicyclic ring systems). For example, heterocycle includes tricyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes tetracyclic ring systems, which may be bridged, fused, spiro, or a combination thereof. For example, heterocycle includes ring systems that are both fused and bridged; ring systems that are both fused and spiro; ring systems that are both bridged and spiro; and ring systems that are both fused and bridged and are also spiro. Each ring of a polycyclic heterocycle may be selected from saturated and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings. A polycyclic heterocycle includes any combination of saturated, and unsaturated (e.g., aromatic or nonaromatic unsaturated) rings, as valence permits. In an exemplary embodiment, an aromatic ring, e.g., pyridyl or phenyl, may be fused to a saturated or unsaturated ring, e.g., cyclohexane, cyclopentane, morpholine, piperidine or cyclohexene, in a heterocycle, as long as at least one atom in the resulting fused ring system is a heteroatom. A polycyclic heterocycle includes any combination of ring sizes such as 3-3 spiro, 4-5 fused ring systems, 5-5 fused ring systems, 5-6 fused ring systems, 6-6 fused ring systems, 5-7 fused ring systems, 6-7 fused ring systems, 5-8 fused ring systems, and 6-8 fused ring systems. A bicyclic heterocycle further includes spiro bicyclic rings, e.g., 5 to 12-membered spiro bicycles, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, a heterocycle comprises multiple heteroatoms. In some embodiments, a heterocycle comprises an atom selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises multiple atoms selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or moreatom(s) selected from nitrogen, oxygen, and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen and sulfur. In some embodiments, a heterocycle comprises one or more atom(s) selected from nitrogen. In some embodiments, a heterocycle comprises one or more atom(s) selected from oxygen. In some embodiments, a heterocycle comprises one or more atom(s) selected from sulfur. Nonlimiting examples of heterocycles include pyridine, pyrrole, indole, carbazole, piperidine, oxazole, morpholine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran. Nonlimiting examples of heterocycles include azepinyl, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl),benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H- benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl).

[0035] In some embodiments, a heterocycle is attached to the molecule by a carbon atom. In someembodiments, the heterocycle is attached to the molecule by a nitrogen atom.

[0036] In some embodiments, a heterocycle comprises a moiety selected from a heteroaryl, aheterocycloalkyl, and a heterocycloalkenyl. In some embodiments, the heterocycle is a heteroaryl. In some embodiments, the heterocycle is a heterocycloalkyl. In some embodiments, the heterocycle is a heterocycloalkenyl.

[0037] In some embodiments, a heterocycle comprises an atom selected from nitrogen and oxygen.In some embodiments, a heterocycle comprises an atom selected from nitrogen and sulfur. In some embodiments, a heterocycle comprises an atom selected from oxygen and sulfur. In some embodiments, a heterocycle comprises an atom selected from nitrogen. In some embodiments, a heterocycle comprises an atom selected from oxygen. In some embodiments, a heterocycle comprises an atom selected from sulfur.

[0038] In some embodiments, a heterocycle comprises 1 to 8 heteroatoms. In some embodiments,the heterocycle comprises 1 to 5 heteroatoms. In some embodiments, the heterocycle comprises 1 to 3 heteroatoms. In some embodiments, the heterocycle comprises 1 to 2 heteroatoms. In someembodiments, the heterocycle comprises 1 heteroatom. In some embodiments, the heterocycle comprises 2 heteroatoms. In some embodiments, the heterocycle comprises 3 heteroatoms. In some embodiments, the heterocycle comprises 4 heteroatoms. In some embodiments, the heterocycle comprises 5 heteroatoms. In some embodiments, the heterocycle comprises 6 heteroatoms.

[0039] In some embodiments, a heterocycle comprises a 3-memberd ring, 4-membered ring, 5-membered ring, 6-membered ring, 7-membered ring, 8-membered ring, 9-membered ring, 10- membered ring, 11-membered ring, 12-membered ring, 13-membered ring, 14-membered ring, or 15-20 membered ring. In some embodiments, a heterocycle is 3- to 10-membered. In some embodiments, a heterocycle is 3- to 6-membered. In some embodiments, a heterocycle is 5- to 6- membered. In some embodiments, a heterocycle is 9- to 10-membered. In some embodiments, a heterocycle is 9- to 11-membered. In some embodiments, a heterocycle is 9- to 15-membered.

[0040] In some embodiments, the heterocycle is monosubstituted, disubstituted, trisubstituted,tetrasubstituted, or pentasubstituted (e.g., with further substituents in addition to the point of attachment). In some embodiments, the total number of substituents (e.g., atoms other than hydrogen) on the heterocycle (e.g., bonded to the ring of the heterocycle) is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more.

[0041] In some embodiments, in the molecule or moiety (e.g., in a heterocycle), one or morenitrogen atoms, if present, can be optionally quaternized. In some embodiments, the heterocycle substituent is positively charged. some embodiments, the heterocycle moiety is neutral. In some embodiments, the heterocycle substituent is zwitterionic. Alternatively, or in addition, in some embodiments, the heterocycle substituent is not charged. In some embodiments, the heterocycle substituent bears no charges. In some embodiments, the heterocycle substituent bears no net charge. In some embodiments, no atoms within the heterocycle substituent bear any net charge. In some embodiments, the heterocycle substituent bears no net charge and is not zwitterionic.The term "heteroaryl" refers to a moiety derived from an aromatic monocyclic or aromatic polycyclic ring system, in which one or more heteroatom(s) is(are) member(s) of the ring system, and the ring system comprises at least one cyclic, delocalized (4n+2) π-electronic system, wherein n is an integer greater than or equal to 0, in accordance with Hückel theory. In some embodiments, one or more heteroatom(s) is(are) member(s) of the ring system comprising the cyclic, delocalized (4n+2) π- electronic system (e.g., the ring with aromaticity). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. In some embodiments, a heteroaryl comprises an aromatic ring, in which one or more heteroatom(s) is(are) member(s) of the ring system, to which one or more nonaromatic rings, each of which may or may not comprise one or more heteroatom(s), may be fused. In some embodiments, a heteroaryl includes one or more heteroatoms selected from nitrogen, oxygen, and sulfur. In someembodiments, a heteroaryl includes multiple heteroatoms selected from nitrogen, oxygen, and sulfur. In certain embodiments, “heteroaryl” includes rings and ring systems comprising 3 to 20 atoms. In some embodiments, “heteroaryl” includes rings and ring systems that comprise two to seventeen carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen and sulfur. As used herein, the heteroaryl moiety is a monocyclic or polycyclic (e.g., bicyclic, tricyclic or tetracyclic) ring system, wherein at least one of the rings in the ring system is aromatic, e.g., it contains a cyclic, delocalized (4n+2) π-electron system in accordance with the Hückel theory.Heteroaryl includes fused, bridged, and spiro ring systems.The heteroatom(s) in the heteroaryl moiety is(are) optionally oxidized.One or more nitrogen atom(s), if present, is(are) optionally quaternized.The heteroaryl is attached to the rest of the molecule through any atom of the ring(s).Examples of heteroaryls include, but are not limited to, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzoxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H- benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl,furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, oxazolyl,5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (e.g., thienyl). In some embodiments, further examples of “heteroaryl” include 5,6,7,8- tetrahydroquinoline; 1,2,3,4-tetrahydro-1,8-naphthyridine; 6,7-dihydro-5H-cyclopenta[b]pyridine; 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 4,5,6,7-tetrahydrobenzofuran; 4,5,6,7-tetrahydrofuro[2,3-b]pyridine; 5,6-dihydro-4H-cyclopenta[b]furan; 4,5-dihydrothieno[2,3-b]furan. In some embodiments, the heteroaryl substituent is positively or negatively charged. In some embodiments, the heteroaryl substituent is neutral. In some embodiments, the heteroaryl substituent is zwitterionic; alternatively, or in addition, in some embodiments, the heteroaryl substituent is not charged. In some embodiments, the heteroaryl substituent bears no charges. In some embodiments, the heteroaryl substituent bears no net charge. In some embodiments, the heteroaryl substituent bears no net charge and is not zwitterionic.

[0042] The term “heterocycle” comprises “heteroaryls,” “heterocycloalkenyls,” and“heterocycloalkyls.”

[0043] The term "heterocycloalkyl" refers to a moiety comprising a saturated ring (e.g., a ring withonly single bonds connecting the members of the ring), wherein the saturated ring comprises carbon atom(s) and one or more heteroatom(s) as member(s) of the saturated ring, and wherein the saturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring. In some embodiments, a heterocycloalkyl may be covalently bound to one or more carbocycle(s) or heterocycle(s). Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, 5- to 12-membered spiro bicycles, or 5- to 12-membered bridged rings. The heteroatoms in the heterocycloalkyl radical are optionally oxidized. One or more nitrogen atoms, if present, are optionally quaternized. The heterocycloalkyl is attached to the rest of the molecule through any atom of the heterocycloalkyl, valence permitting, such as any carbon or nitrogen atoms of the heterocycloalkyl. Examples of heterocycloalkyl radicals include, but are not limited to,dioxolanyl, thienyl[1,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl,isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, 2-oxa-6- azaspiro[3.3]heptane, and 1,1-dioxo-thiomorpholinyl. In some embodiments, a heterocycloalkyl comprises one heteroatom. In some embodiments, a heterocycloalkyl comprises one heteroatom selected from N, O, and S. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms. In some embodiments, a heterocycloalkyl comprises multiple heteroatoms selected from N, O, and S.

[0044] The term "heterocycloalkenyl" refers to a moiety comprising an unsaturated ring (e.g., a ringwith either single bonds or double bonds connecting the members of the ring): wherein the unsaturated ring comprises carbon atoms and one or more heteroatom(s); wherein the unsaturated ring may be optionally fused, bridged with, or spiro to an additional ring, wherein the additional ring may comprise only carbon atoms as members of the additional ring or wherein the additional ring may comprise one or more heteroatom(s) as member(s) of the additional ring; and wherein there is at least one double bond between two ringcarbon atoms (e.g., carbon atoms that are members of the unsaturated ring). Heterocycloalkenyl does not include heteroaryl rings. Exemplary heteroatoms include N, O, Si, P, B, and S atoms. Heterocycloalkenyl may include monocyclic and polycyclic rings such as 3- to 10-membered monocyclic rings, 6- to 12-membered bicyclic rings, and 5- to 12- membered bridged rings. In other embodiments, a heterocycloalkenyl comprises five to seven ring atoms. The heterocycloalkenyl may be attached to the rest of the molecule by a single bond. Examples of monocyclic cycloalkenyls include, e.g., pyrroline (dihydropyrrole), pyrazoline (dihydropyrazole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole), dihydrofuran, dihydrothiophene, oxazoline (dihydrooxazole), isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), isothiazoline (dihydroisothiazole), oxadiazoline (dihydrooxadiazole), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, thiopyran, dihydrothiopyran, dioxine, dihydrodioxine, oxazine, dihydrooxazine, thiazine, and dihydrothiazine.

[0045] A “spirocyclic” moiety (e.g., a “spiro” moiety) (e.g., a spirocyclic heterocycle, a spirocyclicheterocycloalkenyl, a spirocyclic carbocycle, a spirocyclic heterocycloalkyl, a spirocyclic cycloalkenyl, or a spirocyclic cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) system wherein two rings share exactly one atom. Examples of spirocyclic moieties include, but are not limited to:, , , , , , , ,, and

[0046] A spirocyclic heterocycle comprises a spirocyclic moiety that comprises at least oneheteroatom in the ring system of the spirocyclic moiety. Examples of spirocyclic heterocyclesinclude, but are not limited to:, , , , ,, .

[0047] A spirocyclic carbocycle comprises a spirocyclic moiety that comprises only carbon atoms inthe ring system of the spirocyclic moiety. Examples of spirocyclic carbocycles include, but are not limited to:, , , , , ,and.

[0048] A “fused” moiety (e.g., a fused heterocycle, a fused carbocycle, a fused heterocycloalkyl, or afused cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) wherein two rings share exactly two atoms. Examples of fused moieties include, but are not limited to:,, and

[0049] A “fused” heterocycle comprises a fused moiety that comprises at least one heteroatom in thering system of the fused moiety. Examples of fused heterocycles include, but are not limited to:, , , , and

[0050] A “fused” carbocycle comprises a fused moiety that comprises only carbon atoms in the ringsystem of the fused moiety. Examples of fused carbocycles include, but are not limited to:, , , , , , ,, , and.

[0051] A “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle, a bridgedheterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one combination of two bridgeheads, each bridgehead in the combination of two bridgeheads is separated from the other bridgehead in the combination of two bridgeheads by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0052] In some embodiments, a “bridged” moiety (e.g., a bridged heterocycle, a bridged carbocycle,a bridged heterocycloalkyl, a bridged heterocycloalkenyl, or a bridged cycloalkyl) is a polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) which comprises two or more bridgeheads, wherein in at least one pair of bridgeheads, each bridgehead in the pair is separated from the other bridgehead in the pair by three bridges, each bridge comprising at least one atom, wherein each of the three bridges does not contain any of the same atoms as either of the other two bridges.

[0053] In some embodiments, a bridgehead atom is a sp3-hybridized carbon or nitrogen atom thatforms a nexus between two or more rings. In some embodiments, a bridge comprises one or more atom(s) connecting two bridgehead atoms.

[0054] Examples of bridged moieties include, but are not limited to:(bicyclo[1.1.1]pentane),(bicyclo[2.1.1]hexane), norbornane, norbornene2-oxa-5-azabicyclo[2.2.1]heptane 7-oxabicyclo[2.2.1]heptane , 7-azabicyclo[2.2.1]heptanebicyclo[3.1.1]heptanebicyclo[2.2.2]octane, twistane , isotwistane,spiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane],spiro[bicyclo[2.2.1]heptane-2,1'- cyclopropane],, , and

[0055] A “bridged” carbocycle comprises a bridged moiety that comprises only carbon atoms in thering system of the bridged moiety. Examples of bridged carbocycles include, but are not limited to:(bicyclo[1.1.1]pentane),(bicyclo[2.1.1]hexane), norbornanenorbornene, , , bicyclo[3.1.1]heptane, bicyclo[2.2.2]octane,twistane, isotwistane, spiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane], andspiro[bicyclo[2.2.1]heptane-2,1'-cyclopropane].

[0056] A “bridged” heterocycle comprises a bridged moiety that comprises at least one heteroatomin the ring system of the bridged moiety. Examples of bridged heterocycles include, but are not limited to:

[0057] The term “substituted” refers to moieties having substituents replacing a hydrogen on one ormore carbon atom(s) or substitutable heteroatoms, e.g., an NH or NH2 of a compound. It will be understood that “substitution” or “substituted with” includes the implicit proviso that such substitution is in accordance with permitted valence of the substituted atom and the substituent and further includes the proviso that the substitution results in a stable compound, e.g., a compound which does not rapidly undergo rearrangement, cyclization, elimination, etc. In certain embodiments, substituted refers to moieties having substituents replacing two hydrogen atoms on the same carbon atom, such as substituting the two hydrogen atoms on a single carbon atom with an oxo, imino, oxime, hydrazone, or thioxo group. As used herein, the term “substituted” is contemplated to include all permissible substituents of organic compounds. In a broad aspect, the permissible substituents include acyclic and cyclic, branched and unbranched, carbocyclic and heterocyclic, aromatic and non-aromatic substituents of organic compounds. The permissible substituents can be one or more and the same or different for appropriate organic compounds.

[0058] In some embodiments, the term “one or more substituents” may refer to one substituent, ortwo substituents, or three substituents, or four substituents, or five substituents, or six substituents, or more than six substituents. In some embodiments, the term “one or more substituents” may refer to one substituent. In some embodiments, the term “one or more substituents” may refer to two substituents. In some embodiments, the term “one or more substituents” may refer to three substituents. In some embodiments, the term “one or more substituents” may refer to four substituents. In some embodiments, the term “one or more substituents” may refer to five substituents. In some embodiments, the term “one or more substituents” may refer to more than five substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 10 substituents. In some embodiments, the term “one or more substituents” may refer to at least 1 substituent. In some embodiments, the term “one or more substituents” may refer to at most 10 substituents. In some embodiments, the term “one or more substituents” may refer to at most 5 substituents. In some embodiments, the term “one or more substituents” may refer to at most 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 2 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent to 1 substituent.1 substituent to 3 substituents, 1 substituent to 4 substituents, 1 substituent to 5 substituents, 1 substituent to 6 substituents, 1 substituent to 7 substituents, 1 substituent to 10 substituents, 2 substituents to 3 substituents, 2 substituents to 4 substituents, 2 substituents to 5 substituents, 2 substituents to 6 substituents, 2 substituents to 7 substituents, 2 substituents to 10 substituents, 3 substituents to 4 substituents, 3 substituents to 5 substituents, 3 substituents to 6 substituents, 3 substituents to 7 substituents, 3 substituents to 10 substituents, 4 substituents to 5 substituents, 4 substituents to 6 substituents, 4 substituents to 7 substituents, 4 substituents to 10 substituents, 5 substituents to 6 substituents, 5 substituents to 7 substituents, 5 substituents to 10 substituents, 6 substituents to 7 substituents, 6 substituents to 10 substituents, or 7 substituents to 10 substituents. In some embodiments, the term “one or more substituents” may refer to 1 substituent, 2 substituents, 3 substituents, 4 substituents, 5 substituents, 6 substituents, 7 substituents, or 10 substituents.

[0059] In some embodiments, substituents may include any substituents described herein, forexample: halogen, hydroxy, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-OH), hydrazino (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, -Rb-OC(O)-N(Ra)2, - Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, -Rb-N(Ra)C(O)ORa, - Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2), and -Rb-S(O)tN(Ra)2 (where t is 1 or 2); and alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, aralkynyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl,and heteroarylalkyl, any of which may be optionally substituted by alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N- H), oximo (=N-OH), hydrazine (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, - Rb-OC(O)-N(Ra)2, -Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, - Rb-N(Ra)C(O)ORa, -Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and -Rb-S(O)tN(Ra)2 (where t is 1 or 2); wherein each Rais independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl, wherein each Ra, valence permitting, may be optionally substituted with alkyl, alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=N-H), oximo (=N-OH), hydrazine (=N-NH2), -Rb-ORa, -Rb-OC(O)-Ra, -Rb-OC(O)-ORa, -Rb-OC(O)-N(Ra)2, - Rb-N(Ra)2, -Rb-C(O)Ra, -Rb-C(O)ORa, -Rb-C(O)N(Ra)2, -Rb-O-Rc-C(O)N(Ra)2, -Rb-N(Ra)C(O)ORa, - Rb-N(Ra)C(O)Ra, -Rb-N(Ra)S(O)tRa(where t is 1 or 2), -Rb-S(O)tRa(where t is 1 or 2), -Rb-S(O)tORa(where t is 1 or 2) and-Rb-S(O)tN(Ra)2(where t is 1 or 2); and wherein each Rbis independently selected from a direct bond or a straight or branched alkylene, alkenylene, or alkynylene chain, and each Rcis a straight or branched alkylene, alkenylene or alkynylene chain.

[0060] Double bonds to oxygen atoms, such as oxo groups, are represented herein as both “=O” and“(O)”. Double bonds to nitrogen atoms are represented as both “=NR” and “(NR)”. Double bonds to sulfur atoms are represented as both “=S” and “(S)”.

[0061] The phrases “parenteral administration” and “administered parenterally” as used hereinmeans modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intra-arterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal and intrasternal injection and infusion.

[0062] The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds,materials, compositions, and / or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit / risk ratio.

[0063] The phrase “pharmaceutically acceptable excipient” or “pharmaceutically acceptable carrier”as used herein means a pharmaceutically acceptable material, composition or vehicle, such as a liquid or solid filler, diluent, excipient, solvent or encapsulating material. Each carrier must be “acceptable” in the sense of being compatible with the other ingredients of the formulation and not injurious to the patient. Some examples of materials which can serve as pharmaceutically acceptablecarriers include: (1) sugars, such as lactose, glucose and sucrose; (2) starches, such as corn starch and potato starch; (3) cellulose, and its derivatives, such as sodium carboxymethyl cellulose, ethyl cellulose and cellulose acetate; (4) powdered tragacanth; (5) malt; (6) gelatin; (7) talc; (8) excipients, such as cocoa butter and suppository waxes; (9) oils, such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; (10) glycols, such as propylene glycol; (11) polyols, such as glycerin, sorbitol, mannitol and polyethylene glycol; (12) esters, such as ethyl oleate and ethyl laurate; (13) agar; (14) buffering agents, such as magnesium hydroxide and aluminum hydroxide; (15) alginic acid; (16) pyrogen-free water; (17) isotonic saline; (18) Ringer's solution; (19) ethyl alcohol; (20) phosphate buffer solutions; and (21) other non-toxic compatible substances employed in pharmaceutical formulations.

[0064] The term “salt” or “pharmaceutically acceptable salt” refers to salts derived from a variety oforganic and inorganic counter ions well known in the art. Pharmaceutically acceptable acid addition salts can be formed with inorganic acids and / or organic acids. Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Organic acids from which salts can be derived include, for example, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. Pharmaceutically acceptable base addition salts can be formed with inorganic and / or organic bases. Inorganic bases from which salts can be derived include, for example, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum, and the like. Organic bases from which salts can be derived include, for example, primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like, specifically such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine. In some embodiments, the pharmaceutically acceptable base addition salt is selected from ammonium, potassium, sodium, calcium, and magnesium salts.

[0065] As used herein, “treatment” or “treating” refers to an approach for obtaining beneficial ordesired results with respect to a disease, disorder, or medical condition including but not limited to a therapeutic benefit and / or a prophylactic benefit. A therapeutic benefit can include, for example, the eradication or amelioration of the underlying disorder being treated. Also, a therapeutic benefit can include, for example, the eradication or amelioration of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the subject, notwithstanding that the subject may still be afflicted with the underlying disorder. In certainembodiments, for prophylactic benefit, the compositions are administered to a subject at risk of developing a particular disease, or to a subject reporting one or more of the physiological symptoms of a disease, even though a diagnosis of this disease may not have been made. Treatment via administration of a compound described herein does not require the involvement of a medical professional.

[0066] Chemical entities having carbon-carbon double bonds or carbon-nitrogen double bonds mayexist in Z- or E- form (or cis- or trans- form). Furthermore, some chemical entities may exist in various tautomeric forms. Unless otherwise specified, all structures described herein are intended to disclose, implicitly or explicitly, all Z-, E-, and tautomeric forms as well.

[0067] A “tautomer” refers to a molecule wherein a proton shift from one atom of a molecule toanother atom of the same molecule is possible. The compounds presented herein, in certain embodiments, exist as tautomers. In circumstances where tautomerization is possible, a chemical equilibrium of the tautomers will exist. The exact ratio of the tautomers depends on several factors, including physical state, temperature, solvent, and pH. Some examples of tautomeric equilibria include, but are not limited to:.

[0068] The compounds disclosed herein, in some embodiments, are used in different enrichedisotopic forms, e.g., enriched in the content of2H,3H,11C,13C and / or14C. In one particular embodiment, the compound is deuterated in at least one position. Such deuterated forms can be made by the procedure described in U.S. Patent Nos.5,846,514 and 6,334,997. As described in U.S. Patent Nos.5,846,514 and 6,334,997, deuteration can improve the metabolic stability and or efficacy of drugs, thus increasing the duration of action of drugs.

[0069] Unless otherwise stated, compounds described herein are intended to include compoundswhich differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of one or more proton(s) by one or more deuterium(deuteria) or tritium(tritia), or combinations thereof, or except for the replacement of one or more12C atom(s) in the structure by one or more13C atom(s), one or more14C atom(s), or combinations thereof, in the structure are within the scope of the present disclosure.

[0070] The compounds of the present disclosure optionally comprise unnatural proportions of atomicisotopes at one or more atom(s) that constitute such compounds. For example, the compounds maybe labeled with one or more isotope(s), such as for example, deuterium (2H), tritium (3H), iodine-125(125I) or carbon-14 (14C). Isotopic substitution with2H,3H,11C,13C,14C,15C,12N,13N,15N,16N,17O,18O, 14F, 15F, 16F, 17F, 18F, 33S, 34S, 35S, 36S, 35Cl, 37Cl, 79Br, 81Br, and 125I are all contemplated. Allisotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.

[0071] In certain embodiments, the compounds disclosed herein have some or all of the 1H atomsreplaced with2H atoms. The methods of synthesis for deuterium-containing compounds are known in the art and include, by way of non-limiting example only, the following synthetic methods.

[0072] Deuterium-substituted compounds are synthesized using various methods such as describedin: Dean, Dennis C.; Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [In: Curr., Pharm. Des., 2000; 6(10)] 2000, 110 pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0073] Deuterated starting materials are readily available and are subjected to the synthetic methodsdescribed herein to provide for the synthesis of deuterium-containing compounds. Large numbers of deuterium-containing reagents and building blocks are available commercially from chemical vendors, such as MilliporeSigma.

[0074] Included in the present disclosure are salts, particularly pharmaceutically acceptable salts, ofthe compounds described herein. The compounds of the present disclosure that comprise one or more sufficiently acidic functional group(s), one or more sufficiently basic functional group(s), or both one or more sufficiently acidic functional group(s) and one or more sufficiently basic functional group(s)to form a salt (particularly a pharmaceutically acceptable salt), can react with any of a number of inorganic organic bases or inorganic or organic acids, to form a salt. ; combinations thereof); or combinations thereof. Alternatively, compounds that are inherently charged, such as those with a quaternary nitrogen, can form a salt with an appropriate counterion.

[0075] The compounds and salts described herein may in some cases exist as diastereomers,enantiomers, or other stereoisomeric forms. Unless otherwise specified (e.g., in tables of biological data), the structures disclosed herein are intended to include, explicitly or implicitly, disclosure of all diastereomeric (e.g., epimeric) and enantiomeric forms as well as mixtures thereof. Separation of stereoisomers may be performed by chromatography or by forming diastereomers and separating by recrystallization, or chromatography, or any combination thereof. (Jean Jacques, Andre Collet, Samuel H. Wilen, “Enantiomers, Racemates and Resolutions”, John Wiley And Sons, Inc., 1981, herein incorporated by reference for this disclosure). Stereoisomers may also be obtained by stereoselective synthesis.

[0076] In certain embodiments, the compounds or salts of the compounds may be prodrugs. Forexample, in some embodiments, a hydroxyl in the parent compound is presented as an ester or a carbonate, or carboxylic acid present in the parent compound is presented as an ester. The term “prodrug” is intended to encompass compounds which, under physiologic conditions, are converted into pharmaceutical agents of the present disclosure. One method for making a prodrug is to include one or more selected moieties which are hydrolyzed under physiologic conditions to reveal the desired molecule. In other embodiments, the prodrug is converted by an enzymatic activity of the host animal such as specific target cells in the host animal. For example, esters or carbonates (e.g., esters or carbonates of alcohols or carboxylic acids and esters of phosphonic acids) may be prodrugs of the present disclosure. In some embodiments, a prodrug for an amine might rely on enzymatic activation. In some embodiments, a prodrug for an amine might rely on physiological chemical conditions for release of the drugs. In some embodiments, a prodrug for an amine may be selected from an amide, a carbonate, an N-acyloxy alkyl derivative, an N-acyloxy carbonyl derivative, a beta- aminoketone, an (oxodioxolenyl)methyl derivative, an N-Mannich base, an imine (e.g., a Schiff base), an enamine, an enaminone, an azo compound, a system capable of undergoing lactonization, a tetrahydrothiadiazine-2-thione, a redox system, or a PEG.

[0077] Prodrug forms of the herein described compounds, wherein the prodrug is metabolized invivo to produce a compound as set forth herein are included within the scope of the claims. In some cases, some of the herein-described compounds may be a prodrug for another derivative or active compound.

[0078] Prodrugs are often useful because, in some situations, they may be easier to administer thanthe parent drug. They may, for instance, be bioavailable by oral administration whereas the parent is not. Prodrugs may help enhance the cell permeability of a compound relative to the parent drug. The prodrug may also have improved solubility in pharmaceutical compositions over the parent drug.Prodrugs may be designed as reversible drug derivatives, for use as modifiers to enhance drug transport to site-specific tissues or to increase drug residence inside of a cell.

[0079] In some embodiments, the design of a prodrug increases the lipophilicity of thepharmaceutical agent. In some embodiments, the design of a prodrug increases the effective watersolubility. See, e.g., Fedorak et al., Am. J. Physiol., 269:G210-218 (1995); McLoed et al.,Gastroenterol, 106:405-413 (1994); Hochhaus et al., Biomed. Chrom., 6:283-286 (1992); J. Larsen and H. Bundgaard, Int. J. Pharmaceutics, 37, 87 (1987); J. Larsen et al., Int. J. Pharmaceutics, 47, 103 (1988); Sinkula et al., J. Pharm. Sci., 64:181-210 (1975); T. Higuchi and V. Stella, Pro-drugs as Novel Delivery Systems, Vol.14 of the A.C.S. Symposium Series; and Edward B. Roche, Bioreversible Carriers in Drug Design, American Pharmaceutical Association and Pergamon Press, 1987, all incorporated herein for such disclosure). According to another embodiment, the present disclosure provides methods of producing the above-defined compounds. The compounds may be synthesized using conventional techniques. Advantageously, these compounds are conveniently synthesized from readily available starting materials.

[0080] Synthetic chemistry transformations and methodologies useful in synthesizing thecompounds described herein are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations (1989); T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 2d. Ed. (1991); L. Fieser and M. Fieser, Fieser and Fieser’s Reagents for Organic Synthesis (1994); and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis (1995). Compounds

[0081] The following comprises a discussion of compounds and salts thereof that may be used in themethods of the disclosure. In an aspect, provided herein are thiadiazine compounds (e.g., fused thiadiazine compounds).

[0082] In an aspect, provided herein is a compound represented by Formula (I):or a salt thereof, wherein: X1, X2, X3, and X4are each independently selected from C(R1), N, and N+(-O-), wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); each R1is independently selected from:hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a,-S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a,-NO2, =O, =S, =N(R10a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one or more substituents independently selected from R9a; R2is selected from: C1alkyl substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-memberedheterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10- membered heterocycle,wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle isoptionally substituted with one or more substituents independently selected from R9b; or R2together with R7form a 3- to 20- membered heterocycle, optionally substituted with one or more R9d; R3and R4are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, -CN, =O, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O, =S, and =N(R10c); R5and R6are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, =O, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; R7is selected from:hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; or R7together with R2form a 3- to 20- membered heterocycle , optionally substituted with one or more R9d; R8is selected from: hydrogen; C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9e; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2,-OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a,-S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), and -CN; andC1-3 alkyl, C2-3 alkenyl, and C2-3 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2,-OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), and -CN; each R9bis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,-OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b,-S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), and -CN; andC1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,-OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), and -CN; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2,-OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c,-S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), and -CN; andC1-3alkyl, C2-3alkenyl, and C2-3alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2,-OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), and -CN; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d,-S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; andC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, - N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2,-OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e,-S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), and -CN; andC1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2,-OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), and -CN; and each R10a, R10b, R10c, R10d, and R10eis independently selected from: hydrogen; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10 carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6alkyl, -S-C1-6alkyl, -N(C1-6alkyl)2, -NH(C1-6alkyl), C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10-membered heterocycle, and C1-6 haloalkyl.

[0083] In an aspect, provided herein is a compound represented by Formula (Ia):or a salt thereof, wherein: X1, X2, X3, and X4are each independently selected from C(R1) and N, wherein no more than two of X1, X2, X3, and X4are N; each R1is independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, - NH(C1-6 alkyl), -N(C1-6 alkyl)2;C1-6alkyl, and C1-6haloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), - O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C1-6 alkyl, and C1-6 haloalkyl; R2is selected from: C2-6alkyl, optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, halogen, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, and C1-6 alkyl; or R2together with R7form a 6- to 15- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6alkyl, and C1-6haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2; C1-3alkyl and C1-3haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH,-O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle; R3and R4are each independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle; or R3together with R4form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6alkyl, and C1-6haloalkyl; or R3together with R4form a moiety selected from =O; R5and R6are each independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, - NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl and C1-6 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6alkyl and C1-6haloalkyl; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle; R7is selected from: hydrogen; and C1-6alkyl; orR7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; C1-6 alkyl, and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2; C1-3 alkyl and C1-3 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle; and R8is selected from; hydrogen; C1-6alkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0084] In an aspect, provided herein is a compound represented by Formula (Ib):or a salt thereof, wherein: X1, X2, X3, and X4are each independently selected from C(R1) and N, wherein no more than two of X1, X2, X3, and X4are N; each R1is independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, - NH(C1-6 alkyl), -N(C1-6 alkyl)2; C1-6alkyl, and C1-6haloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl; R2together with R7form a 6- to 15- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), and -N(C1-6alkyl)2; C1-6alkyl, and C1-6haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2; C1-3 alkyl and C1-3 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), - O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), - N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle; R3and R4are each independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6 alkyl and C1-6 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C1-6 alkyl, and C1-6 haloalkyl; or R3together with R4form a moiety selected from =O; R5and R6are each independently selected from:hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, - NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6alkyl and C1-6haloalkyl; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle; and R8is selected from; hydrogen; C1-6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle.

[0085] In an aspect, provided herein is a compound represented by Formula (Ic):or a salt thereof, wherein: X1, X2, X3, and X4are each independently selected from C(R1) and N, wherein no more than two of X1, X2, X3, and X4are N; each R1is independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, - NH(C1-6 alkyl), -N(C1-6 alkyl)2; C1-6alkyl, and C1-6haloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), - O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH,-O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C1-6 alkyl, and C1-6 haloalkyl; R2is selected from: C2-6alkyl, optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, halogen, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, and C1-6 alkyl; R3and R4are each independently selected from: hydrogen, halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6alkyl and C1-6haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl; or R3together with R4form a moiety selected from =O; R5and R6are each independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, - NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected fromhalogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl and C1-6 haloalkyl; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle; R7is selected from: hydrogen; and C1-6alkyl; and R8is selected from; hydrogen; C1-6alkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0086] In an aspect, provided herein is a compound represented by Formula (Id):or a salt thereof, wherein: X1, X2, X3, and X4are each independently selected from C(R1) and N, wherein no more than two of X1, X2, X3, and X4are N; each R1is independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, - NH(C1-6 alkyl), -N(C1-6 alkyl)2; C1-6alkyl, and C1-6haloalkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), - O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6alkyl, and C1-6haloalkyl; R2is selected from: C2-6 alkyl, optionally substituted with one or more substituents independently selected from: halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN, halogen, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, and C1-6 alkyl; R5and R6are each independently selected from: hydrogen; halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, - NH(C1-6 alkyl), and -N(C1-6 alkyl)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl and C1-6 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl and C1-6 haloalkyl; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle; R7is selected from: hydrogen; and C1-6alkyl; and R8is selected from; hydrogen; C1-6 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle.

[0087] In some embodiments, the compound or salt of Formula (I) is not a compound or saltdisclosed in WO / 2024 / 206347.

[0088] In some embodiments, for a compound or salt of Formula (I), X1, X2, X3, and X4 are eachindependently selected from C(R1) and N, wherein no more than two of X1, X2, X3, and X4are N. In some embodiments, for a compound or salt of Formula (I), no more than three of X1, X2, X3, and X4are C(H). In some embodiments, no more than three of X1, X2, and X3, are C(H). In someembodiments, no more than three of X1, X2, and X4, are C(H). In some embodiments, no more than three of X2, X3, and X4, are C(H). In some embodiments, X1and X2are not C(H). In some embodiments, X3and X4are C(H). In some embodiments, no more than two of X1, X2, X3, and X4are C(H). In some embodiments, exactly one of X1, X2, X3, and X4is C(H). In some embodiments, exactly two of X1, X2, X3, and X4are C(H). In some embodiments, exactly three of X1, X2, X3, and X4are C(H). Alternatively, in some embodiments, four of X1, X2, X3, and X4are C(H). In some embodiments, when X2, X3, and X4are C(H), then X1is not C(H). In some embodiments, when X1, X3, and X4are C(H), then X2is not C(H). In some embodiments, when X1, X2, and X4are C(H), then X3is not C(H). In some embodiments, when X1, X2, and X3are C(H), then X4is not C(H). In some embodiments, when X2, X3, and X4are C(H), then X1is selected from N, C(F), C(Cl), C(CN), C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X1, X3, and X4are C(H), then X2is selected from N, C(F), C(Cl), C(CN),C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X1, X2, and X4are C(H), then X3is selected from N, C(F), C(Cl), C(CN),C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X1, X2, and X3are C(H), then X4is selected from N, C(F), C(Cl), C(CN),C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X4is N, then R8is -H. In some embodiments, when X4is N, then R8is -H.

[0089] In some embodiments, for a compound or salt of Formula (I), no more than three of X1, X2,X3, and X4are C(H). In some embodiments, no more than three of X1, X2, and X3, are C(H). In some embodiments, no more than three of X1, X2, and X4, are C(H). In some embodiments, no more than three of X2, X3, and X4, are C(H). In some embodiments, X1and X2are not C(H). In some embodiments, X3and X4are C(H). In some embodiments, no more than two of X1, X2, X3, and X4are C(H). In some embodiments, exactly one of X1, X2, X3, and X4is C(H). In some embodiments, exactly two of X1, X2, X3, and X4are C(H). In some embodiments, exactly three of X1, X2, X3, and X4are C(H). Alternatively, in some embodiments, four of X1, X2, X3, and X4are C(H). In some embodiments, when X2, X3, and X4are C(H), then X1is not C(H). In some embodiments, when X1, X3, and X4are C(H), then X2is not C(H). In some embodiments, when X1, X2, and X4are C(H), then X3is not C(H). In some embodiments, when X1, X2, and X3are C(H), then X4is not C(H). In some embodiments, when X2, X3, and X4are C(H), then X1is selected from N, C(F), C(Cl), C(CN), C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X1, X3, and X4are C(H), then X2is selected from N, C(F), C(Cl), C(CN),C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), andC(OCH2F). In some embodiments, when X1, X2, and X4are C(H), then X3is selected from N, C(F), C(Cl), C(CN),C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X1, X2, and X3are C(H), then X4is selected from N, C(F), C(Cl), C(CN),C(OH), C(OCH3), C(CH3), C(Et), C(CF3), C(NH2), C(SH), C(OCF3), C(OCHF2), and C(OCH2F). In some embodiments, when X4is N, then R8is -H. In some embodiments, when X4is N or N+(–O-), then R8is -H. In some embodiments, when X4is not N or N+(–O-).

[0090] In some embodiments, for a compound or salt of Formula (I), no more than one of X1, X2, X3,and X4is N. In some embodiments, no more than one of X1, X2, X3, and X4is N or N+(-O-). In some embodiments, no more than three of X1, X2, X3, and X4is N or N+(-O-). In some embodiments, X1is selected from C(R1), X2is selected from C(R1), X3is selected from C(R1), and X4is selected from C(R1). In some embodiments, one of X1, X2, X3, and X4is N. In some embodiments, one of X1, X2, X3, and X4is N+(–O-). In some embodiments, two of X1, X2, X3, and X4are N. In some embodiments, two of X1, X2, X3, and X4are N+(–O-). In some embodiments, three of X1, X2, X3, and X4are N. In some embodiments, three of X1, X2, X3, and X4are N+(–O-).

[0091] In some embodiments, for a compound or salt of Formula (I), X1 is selected from C(R1) andN. In some embodiments, X1is selected from C(R1). In some embodiments, X1is not N. In some embodiments, X1is selected from C(H), C(F), C(CN), and C(CH3). In some embodiments, X1is selected from C(CN), C(H) and C(F). In some embodiments, X1is selected from C(H) and C(F). In some embodiments, X1is selected from C(H). In some embodiments, X1is selected from C(F). In some embodiments, X1is selected from C(OH), N, C(OCH3), C(F), and C(H). In some embodiments, X1is selected from C(OH), C(OCH3), C(F), and C(H). In some embodiments, X1is selected from C(OH), C(F), and C(H). In some embodiments, X1is selected from C(halogen), C(H), C(CH3), C(OH), and C(OCH3). In some embodiments, X1is selected from C(F), C(H), C(CH3), C(OH), and C(OCH3).

[0092] In some embodiments, for a compound or salt of Formula (I), X2 is selected from C(R1) andN. In some embodiments, X2is not N. In some embodiments, X2is not C(Cl). In some embodiments, X2is selected from N, C(H), C(F), and C(CN). In some embodiments, X2is selected from C(H) and C(F). In some embodiments, X2is selected from C(H). In some embodiments, X2is selected from C(F). In some embodiments, X2is selected from: C(H), N, and C(F). In some embodiments, X2is selected from C(halogen), C(CH3), C(CN), C(H), N. In some embodiments, X2is selected from C(F), C(CH3), C(CN), C(H), N.

[0093] In some embodiments, for a compound or salt of Formula (I), X2 is selected from C(R1) andN. In some embodiments, X2is not N. In some embodiments, X2is selected from N, C(H), C(F), and C(CN). In some embodiments, X2is selected from C(H) and C(F). In some embodiments, X2isselected from C(H). In some embodiments, X2is selected from C(F). In some embodiments, X2is selected from: C(H), N, and C(F). In some embodiments, X2is selected from C(halogen), C(CH3), C(CN), C(H), N. In some embodiments, X2is selected from C(F), C(CH3), C(CN), C(H), N.

[0094] In some embodiments, for a compound or salt of Formula (I), X3 is selected from C(R1) andN. In some embodiments, X3is not N. In some embodiments, X3is selected from C(R1). In some embodiments, X3is selected from C(H). In some embodiments, X3is selected from C(H) and N. In some embodiments, X3is selected from C(H) and C(halogen). In some embodiments, X3is selected from C(H) and C(F).

[0095] In some embodiments, for a compound or salt of Formula (I), X4 is selected from C(R1) andN. In some embodiments, X4is selected from C(R1). In some embodiments, X4is selected from C(H). In some embodiments, X4is selected from N. In some embodiments, X4is not N. In some embodiments, X4is not N or N+(–O-). In some embodiments, X4is not C(R1) or N+(–O-). In some embodiments, X4is C(F). In some embodiments, X4is selected from C(H), C(halogen), and N. In some embodiments, X4is selected from C(H), C(F), and N. In some embodiments, X4is selected from C(H) and N. In some embodiments, X4is selected from C(H).

[0096] In some embodiments, for a compound or salt of Formula (I), X3 and X4 are C(H). In someembodiments, X1is C(H), and X2is C(F); or X1is C(F), and X2is C(F); or X1is C(H), and X2is C(H); or X1is C(H), and X2is C(CN); or X1is C(CH3), and X2is N.

[0097] In some embodiments, for a compound or salt of Formula (I), X1, X2, X3, and X4 are eachindependently selected from C(R1), N, and N+(-O-). In some embodiments, no more than two of X1, X2, X3, and X4are N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1). In some embodiments, at least one of X1, X2, X3, and X4need not be N or N+(-O-). In some embodiments, at least one of X1, X2, X3, or X4is N. In some embodiments, at least one of X1, X2, X3, or X4is N+(O-). In some embodiments, no more than two of X1, X2, X3, and X4are N. In some embodiments, at least one of X1, X2, X3, or X4is N; and no more than two of X1, X2, X3, and X4are N. In some embodiments, no more than three of X1, X2, X3, and X4are N. In some embodiments, at least one of X1, X2, X3, or X4is N; and no more than three of X1, X2, X3, and X4are N. In some embodiments, 0, 1, or 2 of X1, X2, X3, or X4are N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1) and N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1). In some embodiments, one of X1, X2, X3, or X4is N. In some embodiments, no more than one of X1, X2, X3, or X4is N. In some embodiments, X1is N. In some embodiments, X2is N. In some embodiments, X3is N. In some embodiments, X4is N. In some embodiments, two of X1, X2, X3, and X4are N. In some embodiments, no fewer than two of X1, X2, X3, and X4are N. In some embodiments, X1and X3are N. In some embodiments, X2and X4are N.In some embodiments, three of X1, X2, X3, and X4are N. In some embodiments, X1, X2, and X4are N. In some embodiments, X1, X3, and X4are N. In some embodiments, two of X1, X2, X3, and X4are N. In some embodiments, X1and X3are N. In some embodiments, X2and X4are N.

[0098] In certain embodiments, for a compound or salt of Formula (I), X1, X2, X3, and X4 are eachindependently selected from C(R1), N, and N+(-O-). In some embodiments, at least one of X1, X2, X3, or X4is N. In some embodiments, no more than two of X1, X2, X3, and X4are N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1), N, and N+(-O-), wherein at least one of X1, X2, X3, or X4is N; and no more than two of X1, X2, X3, and X4are N. In some embodiments, no more than one of X1, X2, X3, and X4is N. In some embodiments, no more than two of X1, X2, X3, and X4is N. In some embodiments, no more than three of X1, X2, X3, and X4is N. In some embodiments, at least one of X1, X2, X3, or X4is N. In some embodiments, at least two of X1, X2, X3, or X4is N. In some embodiments, at least three of X1, X2, X3, or X4is N. In some embodiments, at least one of X1, X2, X3, or X4is N, and no more than two of X1, X2, X3, and X4are N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1), N, and N+(-O-). In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1) and N. In some embodiments, X1, X2, X3, and X4are each independently selected from C(R1). In some embodiments, X1, X2, X3, and X4are each independently selected from N and C(H). In some embodiments, X1, X2, X3, and X4are each independently selected from N, C(F), C(CN), and C(H). In some embodiments, X1, X2, X3, and X4are each independently selected from C(F), C(CN), and C(H). In some embodiments, one of X1, X2, X3, or X4is N. In some embodiments, two of X1, X2, X3, and X4are N. In some embodiments, three of X1, X2, X3, and X4are N. In some embodiments, one of X1, X2, X3, or X4is C(R1). In some embodiments, two of X1, X2, X3, and X4are C(R1). In some embodiments, three of X1, X2, X3, and X4are C(R1). In some embodiments, four of X1, X2, X3, and X4are C(R1). In some embodiments, X1is N. In some embodiments, X2is N. In some embodiments, X3is N. In some embodiments, X4is N. In some embodiments, X1is C(R1). In some embodiments, X2is C(R1). In some embodiments, X3is C(R1). In some embodiments, X4is C(R1). In some embodiments, X1is C(H). In some embodiments, X2is C(H). In some embodiments, X3is C(H). In some embodiments, X4is C(H). In some embodiments, two of X1, X2, X3, and X4are N. In some embodiments, two of X1, X2, X3, and X4are N, and the two of two of X1, X2, X3, and X4which are N are not bound (e.g., covalently) to each other. In some embodiments, X1and X3are N. In some embodiments, X2and X4are N. In some embodiments, X1is N, and X2, X3, and X4are C(R1). In some embodiments, X2is N, and X1, X3, and X4are C(R1). In some embodiments, X3is N, and X1, X2, and X4are C(R1). In some embodiments, X4is N, and X1, X2, and X3are C(R1). In some embodiments, X1is N, and X2, X3, and X4are C(H). In some embodiments, X2is N, and X1, X3, andX4are C(H). In some embodiments, X3is N, and X1, X2, and X4are C(H). In some embodiments, X4is N, and X1, X2, and X3are C(H).

[0099] In some embodiments, for a compound or salt of Formula (I), each R1 is independentlyselected from: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a,-S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a.

[0100] In some embodiments, for a compound or salt of Formula (I), each R1 is independentlyselected from: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, and -S(O)2R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S,=N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN,C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a.

[0101] In some embodiments, each R1 is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selectedfrom halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN,C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a.

[0102] In some embodiments, each R1 is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; C1-6 alkyl, optionally substitutedwith one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S,=N(R10a), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN,C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9a.

[0103] In some embodiments, each R1 is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; C1-6 alkyl, optionally substitutedwith one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -NO2, =O, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R9a; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, - -NO2, =O, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6alkynyl, wherein C1-6alkyl, C2-6alkenyl, and C2-6alkynyl are each optionally substituted with one or more R9a.

[0104] In some embodiments, each R1 is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; and C1-6 alkyl, optionallysubstituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -NO2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R9a. In some embodiments, each R1is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, and N(R10a)C(O)R10a; and C1-6 alkyl, optionally substituted withone or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)N(R10a)2, and N(R10a)C(O)R10a; and C1-6 alkyl, optionallysubstituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, and -C(O)N(R10a)2; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, - SR10a, -N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -NO2, -CN, and -C(O)N(R10a)2; and C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -NO2, - CN, and -C(O)N(R10a)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -CN, and -C(O)N(R10a)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -CN, and -C(O)N(R10a)2; and C1-6 alkyl. In some embodiments, each R1is independently selected from hydrogen; -CN and - C(O)N(R10a)2; and C1-6 alkyl. In some embodiments, each R1is independently selected from hydrogen; -CN and -C(O)N(R10a)2; and methyl. In some embodiments, each R1is independently selected from hydrogen; -CN and -C(O)N(H)(R10a); and methyl. In some embodiments, each R1is independently selected from hydrogen; -CN and -C(O)NH2; and methyl. In some embodiments, each R1is independently selected fromhydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; and C1-6 alkyl, optionally substituted with one ormore substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -NO2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R9a. In some embodiments, each R1is independently selected fromhydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; and C1-6 alkyl, optionally substituted with one ormore substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -NO2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, each R1is independently selected fromhydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, and -OC(O)R10a; and C1-6 alkyl, optionally substituted with one ormore substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected fromhydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, N(R10a)C(O)R10a, -C(O)OR10a, and -OC(O)R10a; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR10a, -SR10a, -N(R10a)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected fromhydrogen; halogen, -NO2, -CN, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN. In some embodiments, each R1is independently selected from hydrogen; halogen, -NO2, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R1is independently selected from hydrogen; halogen, -CN, -OH, -O(C1-6alkyl), -O(C1-6 haloalkyl), C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, each R1is independently selected from hydrogen; halogen, -CN, -OH, -O(C1 alkyl), and C1 alkyl. In some embodiments, each R1is independently selected from hydrogen; -CN, fluoro, -OH, -O(C1alkyl), and C1alkyl. In some embodiments, each R1is independently selected from: hydrogen, halogen, -CN, - C(O)N(R10a)2, and C1-6 alkyl. In some embodiments, each R1is independently selected from: hydrogen, -F, and -CN. In some embodiments, each R1is independently selected from: hydrogen and -Cl, -F. In some embodiments, each R1is independently selected from: hydrogen and -F.

[0105] In some embodiments, for a compound or salt of Formula (I), R2 is selected from:C1 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10- membered heterocycle,wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle isoptionally substituted with one or more substituents independently selected from R9b; or R2together with R7form a 3- to 20- membered heterocycle, optionally substituted with one or more R9d.

[0106] In some embodiments, for a compound or salt of Formula (I), R2 is selected from: C1 alkylsubstituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C2-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle,wherein each C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle isoptionally substituted with one or more substituents independently selected from R9b; or R2together with R7form a 3- to 20- membered heterocycle, optionally substituted with one or more R9d.

[0107] In some embodiments, for a compound or salt of R2 is selected from: C1-6 alkyl, C2-6 alkenyl,and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b),-CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected fromhalogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b),-CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl,C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected fromhalogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selectedfrom halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b,-C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, -CN, and C1-6 alkyloptionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -NO2, =O, -CN, and C1-6 alkyl optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selectedfrom halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -NO2, =O, -CN, and C1-6alkyl. In some embodiments, R2is selected from: C1-6alkyl, optionallysubstituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, -CN, and C1-6alkyl. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituentsindependently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b,-C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -NO2, =O, and -CN. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b; andC3-10carbocycle. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O,=S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -NO2, =O, -CN, C3-10 carbocycle and 3-to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -NO2, =O, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -NO2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -CN, C3-10 carbocycle and 3- to 10- membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OH, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independentlyselected from fluorine, -OH, -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from fluorine, -OH, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, substituted with one or more substituents independently selected from fluorine, -OH, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-6 alkyl, substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-5 alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-4 alkyl, optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10- membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-3 alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C1-2 alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C2-3 alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R2is selected from: C2-3alkyl, optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C2 alkyl, optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-memberedheterocycle. In some embodiments, R2is selected from: C2alkyl, optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is selected from: C2alkyl, substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted. In some embodiments, R2is selected from: C2alkyl, substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is C2alkyl, optionally substituted with one or more substituents independently selected from C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is C2 alkyl substituted with one or more substituents independently selected from C6carbocycle and 6-membered heterocycle, wherein the C3-10carbocycle and 3- to 10- membered heterocycle are each optionally substituted. In some embodiments, R2is C2 alkyl substituted with one or more substituents independently selected from C6 carbocycle and 6- membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more R9b. In some embodiments, R2is C2 alkyl substituted with one or more substituents independently selected from phenyl, pyridyl, pyrazinyl, pyridazinyl, and pyrimidyl, each of which is optionally substituted. In some embodiments, R2is C2alkyl substituted with one or more substituents independently selected from phenyl, pyridyl, pyrazinyl, pyridazinyl, and pyrimidyl, each of which is optionally substituted with one or more R9b. In some embodiments, R2is C2 alkyl substituted with one or more substituents independently selected from phenyl, pyridyl, pyrazinyl, pyridazinyl and pyrimidyl, each of which is optionally substituted with -halogen, -CN, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl. In some embodiments, R2is C2 alkyl substituted with one or more substituents independently selected from phenyl, pyridyl, pyrazinyl, pyridazinyl and pyrimidyl, each of which is optionally substituted with -halogen, -CN, -OMe, and Me. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from -F, -OH, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted. In some embodiments, R2is selected from: C1-6 alkyl, optionally substituted with one or more substituents independently selected from -F, -OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independentlyselected from R9b. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from -OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted. In some embodiments, R2is selected from: C1-6alkyl, optionally substituted with one or more substituents independently selected from -OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from: C1-3 alkyl, optionally substituted with one or more substituents independently selected from -OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted. In some embodiments, R2is selected from: C1-3alkyl, optionally substituted with one or more substituents independently selected from -OH, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from: C2alkyl, substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted. In some embodiments, R2is selected from: C2alkyl, substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b, wherein the C2alkyl is optionally further substituted with one -OH. In some embodiments, R2is selected from: C2alkyl, substituted with one substituent selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is a substituent represented by the following:wherein,Q1is a C1-5alkyl optionally substituted with one or more substituents selected from OH and halo; each of Y1, Y2, Y3, Y4, and Y5are independently selected from N and C (e.g., C(Q2)); and each Q2is independently selected from hydrogen, halogen, -CN,-OH, -O-C1-6 alkyl, and C1-6 alkyl ; and n is 0, 1, 2, 3, 4, or 5. In some embodiments, R2is a substituent represented by the following:wherein, Q1is a C1-5alkyl optionally substituted with one or more substituents selected from OH and halo; each of Y1, Y2, Y3, Y4, and Y5are independently selected from N and C; and each Q2is independently selected from hydrogen, halogen, -CN, -OH, -O-C1-3alkyl, and C1-3alkyl ; and n is 0, 1, 2, or 3. In some embodiments, R2is a substituent represented by the following:wherein,Q1is a C1-5 alkyl optionally substituted with one or more substituents selected from OH and halo; each of Y1, Y2, Y3, Y4, and Y5are independently selected from N and C; and each Q2is independently selected from hydrogen, -Cl, -F, -CN, -OH, -OMe, and Me; and n is 0, 1, 2, or 3. In some embodiments, R2is a substituent represented by the following:wherein,Q1is a C1-5alkyl optionally substituted with one or more substituents selected from OH and halo; each of Y1, Y2, Y3, Y4, and Y5are independently selected from N and C; and each Q2is independently selected from hydrogen, -F, -CN, -OMe, and Me; and n is 0, 1, 2, or 3. In some embodiments, R2is a substituent represented by the following:wherein,Q1is a C1-5 alkyl optionally substituted with one or more substituents selected from OH and halo; each of Y1, Y2, Y3, Y4, and Y5are independently selected from N and C; and each Q2is independently selected from hydrogen, -F, -OMe, and Me; and n is 0, 1, 2, or 3. In some embodiments, R2 is a substituent represented by the following:, wherein, Q1 is a C1-5 alkyl optionally substituted with one or more substituents selected from OH and halo; Y1and Y2are selected from N and C(Q3); and each Q2is independently selected from halo and CN; each Q3isindependently selected from hydrogen, halo and CN; and n is 0, 1, or 2. In some embodiments, R2isa substituent represented by the following:, wherein, Q1 is a C1 alkyl optionallysubstituted with one or more substituents selected from OH and halo; Y1and Y2are selected from N and C(Q3); and each Q2is independently selected from halo and CN; each Q3is independently selected from hydrogen, halo and CN; and n is 0, 1, or 2. In some embodiments, R2is a substituentrepresented by the following:, wherein, Q1 is a C1 alkyl; Y1 and Y2 are selectedfrom N and C(Q3); and each Q2is independently selected from halo and CN; each Q3is independently selected from hydrogen, halo and CN; and n is 0, 1, or 2. In some embodiments, R2isa substituent represented by the following:, wherein, Q1 is a C1 alkyl; Y1 and Y2 areselected from N and C(Q3); and each Q2is independently selected from halo and CN; each Q3is independently selected from hydrogen, and halo; and n is 0, 1, or 2. In some embodiments, R2is a 11 2 substituent represented by the following:, wherein, Q is a C1 alkyl; Y and Y areselected from N and C(Q3); and each Q2is independently selected from fluoro and CN; each Q3is independently selected from hydrogen, and halo; and n is 0, 1, or 2. In some embodiments, R2is a substituent represented by the following:,wherein, Q1is a C alkyl; Y1and Y2are1 selected from N and C(Q3); and each Q2is independently selected from fluoro and CN; each Q3is independently selected from hydrogen, and fluoro; and n is 0, 1, or 2. In some embodiments, R2is asubstituent represented by the following: 1 1 2, wherein, Q is a C1 alkyl; Y and Y areselected from N and C(Q3); and each Q2is independently selected from fluoro and CN; each Q3is independently selected from hydrogen, and fluoro; and n is 0, 1, or 2. In some embodiments, R2is a substituent represented by the following:, wherein, Q1 is a C1 alkyl; Y1 and Y2 areselected from N and C(Q3); and each Q2is independently selected from fluoro and CN; each Q3is independently selected from hydrogen, and fluoro; and n is 1 or 2. In some embodiments, R2is selected from, and, any of which is optionally substituted. In some embodiments, R2is selected from, ,, and, any of which is optionally substituted with one or more substituents independently selected from: halogen, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C1-6alkyl and C1-6haloalkyl. In some embodiments, R2is selected from, andany of which is optionally substituted. In some embodiments, R2is selected from, ,and, any of which is optionally substituted. In some embodiments, R2is selected from, , ,, and

[0108] In some embodiments, R2 is selected from optionally substituted C3-10 carbocycle and 3- to10-membered heterocycle. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and3- to 10-membered heterocycle, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -N(R10b)C(O)N(R10b)2, - OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle,wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10- membered heterocycle isoptionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -C(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, - N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN,C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10-membered heterocycle isoptionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -C(O)R10b, -NO2, =O, -CN, C1-6alkyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -C(O)R10b, -NO2, =O, -CN, C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6alkylC3-10carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -NO2, =O, -CN, C1-6alkyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), - O(C1-6 haloalkyl), -NO2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C1-6alkyl, C3-10carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -NO2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C1-6 alkyl, C3-10 carbocycle, and 3- to 10- membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, - NH(C1-6 alkyl), -N(C1-6 alkyl)2. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -NO2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -CN, and -CH3. In some embodiments, R2is selected from C3-10carbocycle and 3- to 10-membered heterocycle, eachof which is optionally substituted with one or more substituents independently selected from -F, -CN, and -CH3. In some embodiments, R2is selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -CN. In some embodiments, R2is selected from C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, =O, -CN, and C1-6 alkyl optionally substituted with one or more -F. In some embodiments, R2is selected from C7-10carbocycle and 7- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, =O, -CN, and C1-6 alkyl optionally substituted with one or more -F. In some embodiments, R2is selected from C9-10carbocycle and 9- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F and -CN. In some embodiments, R2is selected from C9 carbocycle and 9-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F and -CN. In some embodiments, R2is selected from 9-membered heterocycle, optionally substituted with one or more substituents independently selected from -F and -CN. In some embodiments, R2is selected from C7-10 carbocycle and 7- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F and -CN. In some embodiments, R2is selected from , and, each of which is optionally substituted. In some embodiments, R2is selected from, and, each of which is optionally substituted with one or more substituents independently selected from: halogen, -CN, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, C1-6alkyl and C1-6haloalkyl. In some embodiments, R2is selected from , and each of which isoptionally substituted with one or more substituents independently selected from -F and -CN. Insome embodiments, R2is selected from, and

[0109] In some embodiments, R2 is selected from: :, , , ,, and

[0110] In some embodiments, for a compound or salt of Formula (I), R2 together with R7 form a 3-to 20- membered heterocycle that is optionally substituted. In some embodiments, R2together with R7form a 3- to 20- membered heterocycle, optionally substituted with one or more R9d. In some embodiments, R7together with R2form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, - C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and - CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 12- membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered bridged heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0111] In some embodiments, for a compound or salt of Formula (I), R2 together with R7 form a 3-to 20- membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) that is optionally substituted. In some embodiments, R2together with R7form a 3- to 20- membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic), optionally substituted with one or more R9d. In some embodiments, R7together with R2form a 3- to 20-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituentsindependently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl,and C2-6alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-memberedheterocycle, each of which is optionally substituted with one or more substituents independentlyselected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), - O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2,=O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 7- to 12-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered bridged heterocycle (e.g., bridged bicyclic or bridged tricyclic) optionally substituted with one ormore substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); and C1 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle.

[0112] In some embodiments, for a compound or salt of Formula (I), R2 together with R7 form a 3-to 20- membered heterocycloalkenyl that is optionally substituted. In some embodiments, R2together with R7form a 3- to 20- membered heterocycloalkenyl, optionally substituted with one or more R9d. In some embodiments, R7together with R2form a 3- to 20-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH,-S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-memberedheterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 3- to 20-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7-to 12-membered heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered bridged heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 15-membered bridged bicyclic heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 12-membered bridged bicyclic heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 12-membered bridged tricyclic heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 7- to 12-membered bridged and fused tricyclic heterocycloalkenyl optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 7- to 12-membered bridged and fused tricyclic heterocycloalkenyl selected from 1,2,3,4-tetrahydro-1,4-(epiminomethano)naphthalenyl and 2,3,4,5-tetrahydro-1H-1,5-methanobenzo[c]azepinyl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and - CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0113] In some embodiments, R7 together with R2 form a 3- to 20- membered heterocycle, optionallysubstituted with one or more substituents independently selected from R9c. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, =O, and -CN; and C1-3alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, =O, and -CN. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OR10c, -N(R10c)2, =O, and -CN; and C1-3alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, =O, and -CN. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OR10c, and -CN; and C1-3 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c,and -CN. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, with one or more substituents independently selected from: halogen, -OR10c, and -CN; and C1-3 alkyl, optionally substituted with one or more substituents independently selected from halogen. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OR10c, and -CN; and C1-3 alkyl. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -CN; and -CH3. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: fluoro, chloro, - OH, -O(CH3), -CN, -CF3, and -CH3. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: fluoro, -CN, and -CH3. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: fluoro and -CN. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more substituents independently selected from: fluoro.

[0114] In some embodiments, R7 together with R2 form a 3- to 20- membered heterocycle that isoptionally substituted. In some embodiments, R7together with R2form a 4- to 19- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 5- to 18- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 6- to 17- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 6- to 16- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 16- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 15- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 14- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 13- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 12- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 11- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 10- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 9- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- to 8- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7-membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 10- to 14-membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 11- to13-membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 12-membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 11- to 13-membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 4- to 19- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 3- to 7- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 3- to 6- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 3- to 5- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 3- to 4- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 3- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 4- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 5- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 6- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 7- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form an 8- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 9- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 10- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 11- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 12- membered heterocycle that is optionally substituted. In some embodiments, R7together with R2form a 3- to 20- membered heterocycle. In some embodiments, R7together with R2form a 3- to 7- membered heterocycle. In some embodiments, R7together with R2form a 3- to 6- membered heterocycle. In some embodiments, R7together with R2form a 3- to 5- membered heterocycle. In some embodiments, R7together with R2form a 3- to 4- membered heterocycle. In some embodiments, R7together with R2form a 3- membered heterocycle. In some embodiments, R7together with R2form a 4- membered heterocycle. In some embodiments, R7together with R2form a 5- membered heterocycle. In some embodiments, R7together with R2form a 6- membered heterocycle. In some embodiments, R7together with R2form a 7- membered heterocycle. In some embodiments, R7together with R2form an 8- membered heterocycle. In some embodiments, R7together with R2form a 9- membered heterocycle. In some embodiments, R7together with R2form a 10- membered heterocycle. In some embodiments, R7together with R2form a 11- membered heterocycle. In some embodiments, R7together with R2form a 12- membered heterocycle.

[0115] In some embodiments, for a compound or salt of Formula (I), R2 together with R7 form a 5-to 12- membered heterocycle that is optionally substituted. In some embodiments, R2together withR7form a 5- to 12- membered heterocycle, optionally substituted with one or more R9d. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d,-C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10aryl and 3- to 10-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d,-C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), -SH, -S(CH3), -NH2, -NMe2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -OH, -SH, -S(CH3), -NH2, - N(CH3)2, =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12- membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 3- to 10-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered bridged heterocycle optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle.

[0116] In some embodiments, R2 together with R7 form a bridged or fused heterocycle, optionallysubstituted with one or more R9d. In some embodiments, R7together with R2form a 5- to 12- membered bridged or fused heterocycle optionally substituted with one or more with one or more R9d. In some embodiments, R7together with R2form a 5- to 12-membered bridged heterocycle optionally substituted with one or more with one or more R9d. In some embodiments, R2together with R7form a bridged or fused heterocycle, substituted with one or more R9d. In some embodiments, R7together with R2form a 5- to 12-membered bridged or fused heterocycle substituted with one or more with one or more R9d. In some embodiments, R7together with R2form a 5- to 12-membered bridged heterocycle substituted with one or more with one or more R9d.

[0117] In some embodiments, R2 together with R7 form a bridged or fused heterocycle, optionallysubstituted with one or more R9d, independently selected from C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered bridged or fused heterocycle optionally substituted with one or more with one or more R9d, independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered bridged heterocycle optionally substituted with one or more with one or more R9d, independently selected from C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R2together with R7form a bridged or fused heterocycle, substituted with one or more R9d, independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered bridged or fused heterocycle substituted with one or more with one or more R9d, independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered bridged heterocycle substituted with one or more with one or more R9d, independently selected from C3-10carbocycle and 3- to 10-membered heterocycle.

[0118] In some embodiments, R7 together with R2 form a 5- to 12-membered heterocycle substitutedwith one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,, -OH, -OMe, - SH, -SMe, -OCHF2, -SO2Me, -NH2, -NMe2, =O, -CN, C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from halogen,OCHF2, -SO2Me, -NH2, -NMe2, =O, -CN, C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl, pyridinyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,, ,=O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl, pyridinyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,,carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl, pyridinyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,carbocycle and 4- to 6-membered heterocycle. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl, pyridinyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,, -OH, -OMe, -OCHF2, -SO2Me, cyclopropyl, oxetanyl, and morpholinyl. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl, pyridinyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,-OH, -OMe, -OCHF2, -SO2Me, cyclopropyl,, and. In some embodiments, R7together with R2form a 5- to 12-membered heterocycle that is optionally substituted with one or more substituents, wherein the one or more substituents are not - SH, -SMe, -NH2, -NMe2, =O, or -CN.

[0119] In some embodiments, R7 together with R2 form a 3- to 20-membered heterocycle selectedfrom:, and, each of which is optionallysubstituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, - C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:, and, each ofwhich is optionally substituted with one or more substituents independently selected from: halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from: , and, each ofwhich is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, , , and, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, , , and, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3-to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:and, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0120] In some embodiments, R7 together with R2 form a heterocycle selected from:,and, each of which is optionally substituted. In some embodiments, R7together with R2form a heterocycle selected from:, ,, and, each of which is optionally substituted with one or more substituents independently selected from R9d. In some embodiments, R7together with R2form a heterocycle selected from:, , , and, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, , , and, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with oneor more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, , , and, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, and, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, , , and, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, and, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0121] In some embodiments, R7 together with R2 form a 3- to 20-membered heterocycle selectedfrom:, , and, each of which is optionally substituted withone or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, - C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substitutedwith one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:and, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and - CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:and, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selectedfrom:, , and, each of which is optionally substituted withone or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycleselected from: , and each of which is optionallysubstituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, and, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle.

[0122] In some embodiments, R7 together with R2 form a heterocycle selected from::and, each of which is optionally substituted. In some embodiments,R7 together with R2 form a heterocycle selected from:, and, each of which is optionally substituted with one or more substituents independently selected from R9d. In some embodiments, R7together with R2form a heterocycle selected from:, and, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, - C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one ormore substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:, , and, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OR10d, - SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and - CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:and, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selectedfrom:, and, each of which is optionally substituted withone or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycleselected from:, and, each of which is optionallysubstituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:, and, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle.

[0123] In some embodiments, R7 together with R2 form a heterocycle selected from:which is optionally substituted. In some embodiments, R7together with R2form a heterocycle selected from: optionally substituted with one or more substituents independently selectedfrom R9d. In some embodiments, R7together with R2form a heterocycle selected from:optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected fromhalogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, - NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and - CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle.

[0124] In some embodiments, R7 together with R2 form a heterocycle selected from:,wherein E is selected from 99d, and w is an integer selected from 0, 1, 2, and 4. In some embodiments, w is 0. In some embodiments, w is 1. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from 99d. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, - OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which isoptionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and - CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form aheterocycle selected from:, wherein E is selected from: halogen, -OH, -O(C1-6 alkyl), - O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, - NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6alkyl); C1alkyl and C1haloalkyl; and C3-10carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OH, -O(CH3), -O(CF3), =O, and -CN; and C1-6alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, - O(CH3), -O(CF3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, - S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or moresubstituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, - O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, - CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl and C1-3 haloalkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -CN, and -CH3. In some embodiments, R7together with R2form a heterocycle selected from:wherein E is selected from: C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d,; C1 alkyl; and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from: wherein E is selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: -F, -O(-CH3), -CH3, C3-10carbocycle, and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: -F, - O(-CH3), -CH3, C3-10carbocycle, and morpholino (e.g., N-morpholino). In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6 aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6 aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6 aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, - OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl and C1-3 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituentsindependently selected from -F, -CN, and -CH3. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl; and C3-10 carbocycle and 3- to 10- membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from C6aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d,; C1 alkyl; and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6 aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: -F, -O(-CH3), -CH3, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6 aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: -F, -O(-CH3), -CH3, and N-morpholino.

[0125] In some embodiments, the 3- to 10- membered heterocycle formed by R2 and R7 is selectedfrom: azabicyclo[2.2.1]hept-5-eny (e.g., 2-azabicyclo[2.2.1]hept-5-enyl), 1,2,3,4-tetrahydro-1,4- (epiminomethano)naphthalenyl and 2,3,4,5-tetrahydro-1H-1,5-methanobenzo[c]azepinyl, each of which is optionally substituted with one or more substituents independently selected from fluoro, chloro, -CH3, -OH, -O(CH3), -SH, -NH2, -CF3, -O(CF3), -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from fluoro, chloro, - CH3, -OH, -O(CH3), -SH, -NH2, -CF3, -O(CF3), -CN, C3-10carbocycle and 3- to 10-membered heterocycle. In some embodiments, the 3- to 10- membered heterocycle formed by R2and R7is selected from: aziridine, azetidine,pyrrolidine, piperidine, morpholine, and azepane, each of which is optionally substituted with one or more substituents independently selected from fluoro, chloro, - CH3, -OH, -O(CH3), -SH, -NH2, -CF3, -O(CF3), and -CN. In some embodiments, the 3- to 10- membered heterocycle formed by R2and R7is selected from: 1,3-diazetidine, indoline, and a hydroquinoline, each of which is optionally substituted with one or more substituents independentlyselected from fluoro, chloro, -CH3, -OH, -O(CH3), -SH, -NH2, -CF3, -O(CF3), and -CN. In some embodiments, the 3- to 10- membered heterocycle formed by R2and R7is selected from: pyrrole, pyridine, indole, imidazole, oxazole, pyridazine, pyrimidine, pyrazine, a triazine, an azaindole, and a quinoline, each of which is optionally substituted with one or more substituents independently selected from fluoro, chloro, -CH3, -OH, -O(CH3), -SH, -NH2, -CF3, -O(CF3), and -CN. In some embodiments, the 3- to 10- membered heterocycle formed by R2and R7is selected from: pyrrole, pyridine, indole, imidazole, oxazole, pyridazine, pyrimidine, pyrazine, a triazine, an azaindole, isoquinoline, and quinoline.

[0126] In some embodiments, R7 together with R2 form a heterocycle selected from:,wherein E is selected from 99d, and w is an integer selected from 0, 1, 2, and 4. In some embodiments, w is 0. In some embodiments, w is 1. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from 99d. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from:halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each ofwhich is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S,=N(R10d), and -CN; and C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OR10d, -SR10d, - N(R10d)2, -NO2, =O, and -CN; and C1-6alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O and - CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substitutedwith one or more substituents independently selected from: halogen, -OR10d, -SR10d, -S(O)2R10d, -N(R10d)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and - CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OH, -O(C1-6alkyl), - O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(O)2(C1-6 alkyl), -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl),-N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; C1-3alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), - NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), - SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, -NO2, =O, and -CN; and C1-6alkyl and C1-6 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(C1-6alkyl),-O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -S(O)2(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -NO2, =O, and -CN; and C1-6 alkyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, and =O; and C3-10 carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: halogen, -OH, -O(CH3), - O(CF3), =O, and -CN; and C1-6alkyl and C1-6haloalkyl; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -OCHF2, -SO2(CH3), -CH3,, , , -CHF2, - CF3, -CH2CF3, and; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, and -O(C1-6 alkyl); C1 alkyl and C1 haloalkyl; and C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from:halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-4 alkyl optionally substituted with one or moresubstituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(O)2R10d, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -S(O)2(C1-6 alkyl), -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl optionally substituted with one or moresubstituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, - OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6alkyl), -NH2, -NH(C1-6alkyl), -N(C1-6alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -S(O)2R10d, -N(R10d)2, -NO2, =O, and -CN; C1-3 alkyl and C1-3 haloalkyl; and C3-10 carbocycle and 3-to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from -F, -CN, and -CH3. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OH, -O(CH3), -OCHF2, -SO2(CH3), -CH3,, , , -CHF2, - CF3, -CH2CF3, and; and C3-10 carbocycle and 3- to 10-membered heterocycle. In someembodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from: C6aryl and 5- to 6-membered heteroaryl, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6alkyl), -O(C1-6haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6 haloalkyl, C3-10 carbocycle, and 3- to 10-membered heterocycle..

[0127] In some embodiments, R7 together with R2 form a heterocycle selected from:wherein E is selected from C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,-OH, -OMe, -SH, -SMe, -OCHF2, -SO2Me, -NH2, -NMe2, =O, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me, ,-CF3,-OH, -OMe, -SH, -SMe, -OCHF2, -SO2Me, -NH2, -NMe2, =O, -CN, C1-6 alkyl,C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from phenyl pyridyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,, , , , , , , -OH, -OMe, -OCHF2, -SO2Me, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from C3-10carbocycle and 3- to 10- membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,-OH, -OMe, -SH, -SMe, -OCHF2, -SO2Me, -NH2, -NMe2, =O, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:, wherein E is selected from aryl and heteroaryl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me, , -OH, -OMe, -SH, -SMe, -OCHF2, -SO2Me,-NH2, -NMe2, =O, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle. In some embodiments, R7together with R2form a heterocycle selected from:wherein E is selected from phenyl pyridyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4- b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,, -OH, -OMe, - OCHF2, -SO2Me, -C3-10 carbocycle and 3- to 10-membered heterocycle.

[0128] In some embodiments, R7 together with R2 form a heterocycle selected from:,wherein E is selected from:, , , and .

[0129] In some embodiments, R7 together with R2 form a heterocycle selected from:,wherein E is selected from:,, , ,

[0130] In some embodiments, R7 together with R2 form a heterocycle selected from:,wherein E is selected from:, , , , ,, , ,

[0131] In some embodiments, R7 together with R2 form a heterocycle selected from:wherein E is selected from:, , ,

[0132] In some embodiments, R7 together with R2 form a heterocycle selected from: :, and, each of which is optionally substituted. In some embodiments, R7together with R2form a heterocycle selected from: :

[0133] In some embodiments, R7 together with R2 form a heterocycle selected from: :, , , ,, and, each of which is optionally substituted. In some embodiments, R7together with R2form a heterocycle selected from: :, , , ,, , , , and

[0134] In some embodiments, for a compound or salt of Formula (I), R2 together with R7 form a 3-to 20- membered heterocycle, optionally substituted with one or more R9d, provided the 3- to 20- membered heterocycle is not morpholine.

[0135] In some embodiments, for a compound or salt of Formula (I), R3 is selected from:hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, -CN, =O, C3-10carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O, =S, =N(R10c), and =N–O(R10c).

[0136] In some embodiments, for a compound or salt of Formula (I), R4 is selected from:hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, -CN, =O, C3-10carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O, =S, =N(R10c), and =N–O(R10c).

[0137] In some embodiments, R3 and R4 are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; C1-6 alkyl, optionally substituted with one or moresubstituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-memberedheterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen,-OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; C1-6 alkyl, substituted with one or more substituentsindependently selected from C3-10carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen; C1-6alkyl, substituted with one or more substituents independently selected from C3-10 carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from halogen, -CN, -NO2, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, -S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, C1-6 alkyl, and C1-6 haloalkyl; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen; or R3together with R4form a 3- to 10- membered heterocycle or C3-10carbocycle; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen; or R3together with R4form a moiety selected from =O. In some embodiments, R3and R4are each independently selected from: hydrogen; or R3together with R4form a 3- to 10-membered heterocycle or C3-10carbocycle. In some embodiments, R3and R4are each independently selected from: hydrogen.

[0138] In some embodiments, R3 and R4 are each independently selected from hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or moresubstituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN. In someembodiments, R3 and R4 are each independently selected from hydrogen, halogen, -OR10c, -N(R10c)2,-NO2, and -CN; and C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -N(R10c)2, -NO2, and -CN. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen, -NO2, -CN, C1-6 alkyl and C1-6 haloalkyl. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen, C1-6alkyl and C1-6haloalkyl. In some embodiments, R3and R4are each independently selected from: hydrogen, C1-6alkyl and C1-6 haloalkyl. In some embodiments, R3and R4are each independently selected from hydrogen and C1-6 alkyl. In some embodiments, R3and R4are each independently selected from: hydrogen and methyl. In some embodiments, R3and R4are each hydrogen. In some embodiments, R3is hydrogen. In some embodiments, R4is hydrogen. In certain embodiments, R3and R4are eachindependently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; and C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, - OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c. In some embodiments, R3and R4are each independentlyselected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN; and C1-6 alkyl optionallysubstituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -NO2, and -CN; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more R9c. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen, -NO2, and -CN; and C1-6 alkyl optionally substituted with one or more halogen; or R3together with R4form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c. In some embodiments, R3and R4are each independently selected from: hydrogen, halogen, -NO2, and -CN; and C1-6alkyl optionally substituted with one or more halogen; or R3together with R4form a 3- to 10- membered heterocycle or C3-10carbocycle. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more halogen; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1-6alkyl optionallysubstituted with one or more halogen. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1-6 alkyl. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1 alkyl. In some embodiments, R3and R4are each independently selected from: hydrogen. In some embodiments, R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle. In some embodiments, the 3- to 10- membered heterocycle or C3-10 carbocycle formed by R3together with R4is selected from cyclopropyl and oxetanyl. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1alkyl; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1 alkyl; or R3together with R4form a C3-10carbocycle. In some embodiments, R3and R4are each independently selected from: hydrogen; and C1alkyl; or R3together with R4form a C3-10carbocycle, wherein the C3-10carbocycle is cyclopropane. In some embodiments, R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c. In some embodiments, R3together with R4form a C3-10carbocycle, the C3-10carbocycle is optionally substituted with one or more R9c. In some embodiments, R3together with R4form a C3-10 carbocycle. In some embodiments, R3together with R4form a C3-10 carbocycle selected from cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. In some embodiments, R3together withR4 form a ring selected from, andIn some embodiments, R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle. In some embodiments, R3together with R4form a C3-10carbocycle. In some embodiments, R3together with R4form a C4-8carbocycle that is optionally substituted. In some embodiments, R3together with R4form a C4-8 carbocycle. In some embodiments, R3together with R4form a C6 carbocycle that is optionally substituted. In some embodiments, R3together with R4form a C6carbocycle. In some embodiments, R3together with R4form a C3-6carbocycle that is optionally substituted. In some embodiments, R3together with R4form a C3-6 carbocycle. In some embodiments, R3together with R4form a C3-4 carbocycle that is optionally substituted. In some embodiments, R3together with R4form a C3-4carbocycle. In some embodiments, R3together with R4form a C3carbocycle that is optionally substituted. In some embodiments, R3together with R4form a C3 carbocycle that is optionally substituted with one or more -F. In some embodiments, R3together with R4form a C63 carbocycle.

[0139] In some embodiments, R3 and R4 are each hydrogen. In some embodiments, R3 is hydrogen.In some embodiments, R4is hydrogen. In some embodiments, R3is hydrogen, and R4is methyl. Insome embodiments, R3is hydrogen, and R4is C1-6alkyl. In some embodiments, R3is -H, and R4is - OH. In some embodiments, R3is -OH, and R4is -H. In some embodiments, R3is -OH.

[0140] In some embodiments, R3 together with R4 form a moiety selected from =O, =S, =N(R10c),and =N–O(R10c). In some embodiments, R3together with R4form a moiety selected from =O, =S, and=N(R10c). In some embodiments, R3together with R4form a moiety selected from =O, =N(R10c), and =N–O(R10c). In some embodiments, R3together with R4form a moiety selected from =O and =N(R10c). In some embodiments, R3together with R4form a moiety selected from =O.

[0141] In some embodiments, for a compound or salt of Formula (I), R5 and R6 are eachindependently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, =O, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c.

[0142] In some embodiments, R5 and R6 are each independently selected from: hydrogen, halogen, -OR10c, and -N(R10c)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R5together with R6form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5and R6are each independently selected from: hydrogen, halogen, -OR10c, and -N(R10c)2; C1-6alkyl, substituted with one or more substituents independently selected from halogen, C3-10carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one ormore substituents independently selected from R9c; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c. In some embodiments, R5and R6are each independently selected from: hydrogen,and. In some embodiments, R5and R6are each independently selected from: hydrogen, and C1-3alkyl optionally substituted with cyclopropyl.

[0143] In some embodiments, R5 is selected from: hydrogen. In some embodiments, R5 is selectedfrom: hydrogen, and R6is selected from hydrogen. In some embodiments, R5is selected from: benzyl, and R6is selected from hydrogen. In some embodiments, R5is selected from and R6is selected from hydrogen. In some embodiments, R5is selected fromand R6is selected from hydrogen. In some embodiments, R5is selected fromand R6is selected from hydrogen. In some embodiments, R5is selected fromand R6is selected from hydrogen. In some embodiments, R5is selected fromand R6is selected from hydrogen.

[0144] In some embodiments, R5 is selected from hydrogen; halogen, -C(O)R10c, -C(O)N(R10c)2, -C(O)OR10c, -S(O)R10c, -S(O)2R10c, -NO2, -N3, and -CN; C1-6 alkyl, C2-6 alkenyl, andC2-6 alkynyl, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R1...

Claims

CLAIMS WHAT IS CLAIMED IS:

1. A compound represented by Formula (I):or a salt thereof, wherein: X1, X2, X3, and X4are each independently selected from C(R1), N, and N+(-O-), wherein no more than two of X1, X2, X3, and X4are N or N+(-O-); each R1is independently selected from: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a,-S(O)R10a, and -S(O)2R10a; C1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -C(O)OR10a, -OC(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9a; and C3-10carbocycle and 3- to 15-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2, -OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a,-NO2, =O, =S, =N(R10a), -CN, C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein each C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl is optionally substituted with one or more substituents independently selected from R9a; R2is selected from: C1 alkyl substituted with one or more substituents independently selected from halogen, - OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, - S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10 carbocycle and 3- to 10-memberedheterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more R9b; and C2-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -C(O)OR10b, -OC(O)R10b, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), -CN, C3-10carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)N(R10b)2, -OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S,=N(R10b), -CN, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, and 3- to 10- membered heterocycle, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle, and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9b; or R2together with R7form a 3- to 20- membered heterocycle, optionally substituted with one or more R9d; R3and R4are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, -CN, =O, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10carbocycle is optionally substituted with one or more substituents independently selected from R9c; or R3together with R4form a moiety selected from =O, =S, =N(R10c), and =N–O(R10c); R5and R6are each independently selected from: hydrogen, halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, and -CN;C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, -NO2, =O, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9c; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9c; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from R9c; R7is selected from: hydrogen; and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, -NO2, -CN, C3-10carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9d; or R7together with R2form a 3- to 20- membered heterocycle, optionally substituted with one or more R9d; R8is selected from: hydrogen; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle, wherein each C3-10carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from R9e; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from R9e; each R9ais independently selected from: halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2,-OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a,-S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), and -CN; andC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, -C(O)R10a, -C(O)N(R10a)2, -N(R10a)C(O)R10a, -N(R10a)C(O)N(R10a)2,-OC(O)N(R10a)2, -N(R10a)C(O)OR10a, -C(O)OR10a, -OC(O)R10a, -S(O)R10a, -S(O)2R10a, -NO2, =O, =S, =N(R10a), and -CN; each R9bis independently selected from: halogen, -OR10b, -SR10b, -N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,-OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b,-S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), and -CN; andC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -C(O)R10b, -C(O)N(R10b)2, -N(R10b)C(O)R10b, -N(R10b)C(O)N(R10b)2,-OC(O)N(R10b)2, -N(R10b)C(O)OR10b, -C(O)OR10b, -OC(O)R10b, -S(O)R10b, -S(O)2R10b, -NO2, =O, =S, =N(R10b), and -CN; each R9cis independently selected from: halogen, -OR10c, -SR10c, -N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2,-OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c,-S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), and -CN; andC1-6alkyl, C2-6alkenyl, and C2-6alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, - N(R10c)2, -C(O)R10c, -C(O)N(R10c)2, -N(R10c)C(O)R10c, -N(R10c)C(O)N(R10c)2,-OC(O)N(R10c)2, -N(R10c)C(O)OR10c, -C(O)OR10c, -OC(O)R10c, -S(O)R10c, -S(O)2R10c, -NO2, =O, =S, =N(R10c), and -CN; each R9dis independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d,-S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; andC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, - N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d, -N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -SR10d, -N(R10d)2, -C(O)R10d, -C(O)N(R10d)2, -N(R10d)C(O)R10d,-N(R10d)C(O)N(R10d)2,-OC(O)N(R10d)2, -N(R10d)C(O)OR10d, -C(O)OR10d, -OC(O)R10d, -S(O)R10d, -S(O)2R10d, -NO2, =O, =S, =N(R10d), and -CN; C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, -OH, -SH, -NH2, =O, -CN, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -SH, - S(C1-6 alkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, =O, -CN, C1-6 alkyl, C1-6haloalkyl, C3-10carbocycle, and 3- to 10-membered heterocycle; each R9eis independently selected from: halogen, -OR10e, -SR10e, -N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2,-OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e,-S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), and -CN; andC1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, - N(R10e)2, -C(O)R10e, -C(O)N(R10e)2, -N(R10e)C(O)R10e, -N(R10e)C(O)N(R10e)2,-OC(O)N(R10e)2, -N(R10e)C(O)OR10e, -C(O)OR10e, -OC(O)R10e, -S(O)R10e, -S(O)2R10e, -NO2, =O, =S, =N(R10e), and -CN; and each R10a, R10b, R10c, R10d, and R10eis independently selected from: hydrogen; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C3-10 carbocycle, 3- to 10-membered heterocycle; and C3-10carbocycle, and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -CN, -OH, -SH, - NO2, -NH2, =O, =S, -O-C1-6 alkyl, -S-C1-6 alkyl, -N(C1-6 alkyl)2, -NH(C1-6 alkyl), C1-6 alkyl, C2-6alkenyl, C2-6alkynyl, C3-10carbocycle, 3- to 10-membered heterocycle, and C1-6haloalkyl.

2. The compound or salt of claim 1, wherein X1, X2, X3, and X4 are each independently selectedfrom C(R1) and N.

3. The compound or salt of claim 1 or claim 2, wherein X1, X2, X3, and X4 are eachindependently selected from C(R1).

4. The compound or salt of claim 1 or claim 2, wherein X2 is N or X3 is N.

5. The compound or salt of any one of claims 1 to 4, wherein each R1 is independently selectedfrom: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, and -N(R10a)2; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9a; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, - N(R10a)2, =O, -CN, and C1-6 alkyl, wherein each C1-6 alkyl is optionally substituted with one or more substituents independently selected from R9a.

6. The compound or salt of any one of claims 1 to 5, wherein each R1 is independently selectedfrom: hydrogen; halogen, -NO2, -CN, -OR10a, -SR10a, and -N(R10a)2; C1-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10a, -SR10a, -N(R10a)2, =O, -CN, C3-10 carbocycle and 3- to 10-membered heterocycle; and C3-10carbocycle and 3- to 10-membered heterocycle.

7. The compound or salt of any one of claims 1 to 6, wherein each R1 is independently selectedfrom: hydrogen, fluoro, -OH, -O(CH3), and C1-6 alkyl.

8. The compound or salt of any one of claims 1 to 7, wherein each R1 is independently selectedfrom: hydrogen and fluoro.

9. The compound or salt of any one of claims 1 to 8, wherein R2 is selected from:C2-6alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, =O, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9b; andC3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - N(R10b)2, -NO2, =O, =S, -CN, and C1-6 alkyl, wherein each C1-6 alkyl is optionally substituted with one or more substituents independently selected from R9b.

10. The compound or salt of any one of claims 1 to 9, wherein R2 is selected from:C2-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, =O, C3-10carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9b; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, - NO2, =O, -CN, and C1-6 alkyl.

11. The compound or salt of any one of claims 1 to 10, wherein R2 is selected from:C2-3 alkyl, optionally substituted with one or more substituents independently selected from: C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents independently selected from R9b; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected -CN.

12. The compound or salt of any one of claims 1 to 11, wherein R2 is selected from: C2 alkylsubstituted with one or more substituents independently selected from C6 carbocycle, 6- membered heterocycle, and 9- to 10- membered bicyclic heterocycle, wherein the C6 carbocycle, 6- membered heterocycle, and 9- to 10- membered bicyclic heterocycle are each optionally substituted with one or more substituents independently selected from R9b.

13. The compound or salt of any one of claims 1 to 12, wherein R2 is selected from: C2 alkylsubstituted with one substituent selected from: phenyl, pyridyl, pyrimidinyl, and pyridazinyl, each of which is optionally substituted with one or more substituents independently selected from R9b.

14. The compound or salt of any one of claims 1 to 13, wherein R2 is selected from: C2 alkylsubstituted with one substituent selected from: phenyl, pyridyl, pyrimidinyl, and pyridazinyl, each of which is optionally substituted with one or more substituents independently selected from fluoro, -CN, -O(CH3), and -CH3.

15. The compound or salt of any one of claims 1 to 14, wherein R2 is a substituent represented bythe following:wherein, Q1is a C1-5alkyl optionally substituted with one or more substituents independently selected from -OH and halogen; each Y1, Y2, Y3, Y4, and Y5is independently selected from N and C(Q2); and each Q2is independently selected from hydrogen, halogen, -CN, -OH, -O-C1-6alkyl, and C1-6alkyl.

16. The compound or salt of any one of claims 1 to 15 wherein R2 is selected from:

17. The compound or salt of any one of claims 1 to 9, wherein R2 is selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR10b, -SR10b, -N(R10b)2, - NO2, =O, =S, -CN, and C1-6 alkyl, wherein each C1-6 alkyl is optionally substituted with one or more substituents independently selected from R9b.

18. The compound or salt of claim 17, wherein R2 is selected from,, and19. The compound or salt of any one of claims 1 to 18, wherein R3 and R4 are each independentlyselected from: hydrogen, fluoro, and C1-6 alkyl; or R3together with R4form a 3- to 10- membered heterocycle or C3-10carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more R9c; or R3together with R4form a moiety selected from =O.

20. The compound or salt of any one of claims 1 to 19, wherein R3 and R4 are each independentlyselected from: hydrogen.

21. The compound or salt of any one of claims 1 to 19, wherein R3 together with R4 form amoiety selected from =O.

22. The compound or salt of any one of claims 1 to 21, wherein R5 and R6 are each independentlyselected from: hydrogen, halogen, and -CN; C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, C3-10 carbocycle, and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from halogen and -CN; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from C1-6alkyl, C1-6haloalkyl, halogen, - and -CN; or R5together with R6form a 3- to 10- membered heterocycle or C3-10 carbocycle, wherein the 3- to 10- membered heterocycle or C3-10 carbocycle is optionally substituted with one or more substituents independently selected from halogen and -CN.

23. The compound or salt of any one of claims 1 to 22, wherein R5 and R6 are each independentlyselected from: hydrogen, benzyl, and.

24. The compound or salt of any one of claims 1 to 22, wherein R5 and R6 are each independentlyselected from: hydrogen, and C3-10carbocycle, optionally substituted with one or more substituents independently selected from C1-6 alkyl, C1-6 haloalkyl,halogen.

25. The compound or salt of claim 24, wherein R5 and R6 are each independently selected from:hydrogen, and C3-6carbocycle, optionally substituted with one or more substituents independently selected from C1-6alkyl, C1-3haloalkyl, and halogen.

26. The compound or salt of claim 25, wherein R5 and R6 are each independently selected from:hydrogen, and C3-6 carbocycle, optionally substituted with one or more substituents independently selected from methyl, trifluoromethyl, and fluorine.

27. The compound or salt of any one of claims 1 to 22, wherein R5 and R6 are each independentlyselected from: hydrogen, benzyl, -CH2-cyclopropyl, bicyclo[1.1.1]pentanyl substituted with one -CF3 group, cyclohexyl substituted with two fluorine groups, azetidinyl, cyclobutyl substituted with two methyl groups, or R5together with R6form a C3carbocycle.

28. The compound or salt of any one of claims 1 to 27, wherein R5 and R6 are each hydrogen.

29. The compound or salt of any one of claims 1 to 28, wherein R7 is selected from hydrogen.

30. The compound or salt of any one of claims 1 to 8, or any one of claims 19 to 28 wherein R7together with R2form a 3- to 15- membered heterocycle optionally substituted with one or more R9d.

31. The compound or salt of claim 30, wherein R7 together with R2 form a 5- to 12- memberedheterocycle that is optionally substituted with one or more substituents independently selected from halogen, -OH, -OMe, -SH, -SMe, -NH2, -NMe2, =O, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -Me, -OH, -OMe, -SH, -SMe, -SO2Me, -NH2, -NMe2, =O, -CN, C1-6 alkyl, C3-10 carbocycle and 3- to 10-membered heterocycle.

32. The compound or salt of claim 31, wherein R7 together with R2 form a 5- to 12- memberedbridged heterocycle that is optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -Me, ,-CF3,, -OH, -OMe, -OCHF2, -SH, -SMe, -SO2Me, -NH2, -NMe2, =O, -CN, C3-10carbocycle and 3- to 10-membered heterocycle.

33. The compound or salt of any one of claims 1 to 32, wherein R7 together with R2 form abridged heterocycle that is optionally substituted with one or more substituents independently selected from C3-10 carbocycle and 3- to 10-membered heterocycle, wherein the C3-10 carbocycle and 3- to 10-membered heterocycle is optionally substituted with one or more substituents independently selected from halogen, -Me, -OH, -OMe, -SH, -SMe, -NH2, - NMe2, =O, -CN, C1-6 alkyl,-C3-10 carbocycle and 3- to 10-membered heterocycle.

34. The compound or salt of claim 33, wherein R7 together with R2 form bridged 7- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl, pyridyl, pyrimidinyl, pyrazolyl, oxazolyl, thiazolyl, and [1,2,5]oxadiazolo[3,4-b]pyridinyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me,, -OH, -OMe, -OCHF2, -SO2Me, C3-10 carbocycle and 3- to 10-membered heterocycle.

35. The compound or salt of claim 34, wherein R7 together with R2 form bridged 7- to 12-membered heterocycle that is optionally substituted with one or more substituents independently selected from phenyl and pyridyl, each of which is optionally substituted with one or more substituents independently selected from halogen, -Me, -OH, -OMe, and -CN.

36. The compound or salt of claim 35, wherein R7 together with R2 form a 7- to 12 memberedheterocycle selected from, , , ,, , ,37. The compound or salt of claim 36, wherein R7 together with R2 form a 7- to 12 memberedheterocycle selected from38. The compound or salt of any one of claims 1 to 37, wherein R8 is selected from:hydrogen; and C1-6alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10e, -SR10e, -N(R10e)2, -NO2, -CN, C3-10 carbocycle, and 3- to 10- membered heterocycle.

39. The compound or salt of any one of claims 1 to 38, wherein R8 is selected from hydrogen.

40. The compound or salt of any one of claims 1 to 39, wherein each R9a is independentlyselected from: halogen and -CN.

41. The compound or salt of any one of claims 1 to 40, wherein each R9b is independentlyselected from: halogen, -O(CH3), -CN.

42. The compound or salt of any one of claims 1 to 41, wherein each R9c is independentlyselected from: halogen, -OR10c, -SR10c, -N(R10c)2, and -CN; and C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen, -OR10c, -SR10c, -N(R10c)2, =O, and -CN.

43. The compound or salt of any one of claims 1 to 42, wherein each R9c is independentlyselected from: halogen and C1-3 alkyl optionally substituted with one or more substituents independently selected from halogen.

44. The compound or salt of any one of claims 1 to 43, wherein each R9c is independentlyselected from: fluorine, methyl, and -CF3.

45. The compound or salt of any one of claims 1 to 44, wherein each R9d is independentlyselected from: halogen, -OR10d, -SR10d, -N(R10d)2, =O, and -CN; and C1-6 alkyl, optionally substituted with one or more substituents independently selected from halogen, -OR10d, -SR10d, -N(R10d)2, =O, and -CN; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -OR10d, -S(O)2R10d, -SR10d, -N(R10d)2, =O, and -CN;C1-3alkyl, optionally substituted with one or more substituents independently selected from halogen, -OH, C3-10carbocycle, and 3- to 10-membered heterocycle; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independentlyselected from halogen, -OH, -SH, -NH2, =O, -CN, C1-3alkyl, and 3- to 10-membered heterocycle.

46. The compound or salt of claim 45, wherein each R9d is independently selected from:halogen, -OH, -O(C1-6 alkyl), -O(C1-6 haloalkyl), -NH2, -NH(C1-6 alkyl), -N(C1-6 alkyl)2, -SH, -S(C1-6 alkyl), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -O(CH3), -S(O)2(CH3), -OH, =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from C1-3 alkyl, and 3- to 10-membered heterocycle.

47. The compound or salt of claim 46, wherein each R9d is independently selected from:halogen, -OH, =O, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -O(CH3), -S(O)2(CH3), -OH, =O, -CN, and -CH3; and C3-10 carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from C1-3alkyl, and 3- to 10-membered heterocycle.

48. The compound or salt of claim 47, wherein each R9d is independently selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -O(CH3), -OH, -S(O)2(CH3), =O, -CN, and -CH3; and C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from C1-3 alkyl, and 3- to 10-membered heterocycle.

49. The compound or salt of claim 48, wherein each R9d is independently selected from: C3-10carbocycle and 3- to 10-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from: halogen, -O(CH3), C3-10 carbocycle, and 3- to 10-membered heterocycle.

50. The compound or salt of any one of claims 1 to 49, wherein each R10a, R10b, R10c, R10d, andR10eis independently selected from: hydrogen, halogen, and C1-6 alkyl optionally substituted with one or more halogen, C3-10 carbocycle, and 3- to 10-membered heterocycle.

51. The compound or salt of claim 50, wherein each R10a, R10b, R10c, R10d, and R10e isindependently selected from: hydrogen, -CH3, and -CHF2.

52. The compound or salt of claim 51, wherein each R10a, R10b, R10c, R10d, and R10e isindependently selected from: hydrogen.

53. The compound or salt of claim 1 wherein the compound is selected from: compounds: A1,A2, A3, A4, A5, A6, A7, A8, A9, A10, A11, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A47, A48, A49, A50, A51, A52, A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, A65, A66, , A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, A80, A81, A82, A83, A84, A85, A86, A87, A88, A89, A90, A91, A92, A93, A94, A95, A96, A97, A98, A99, A100, A101, A102, A103, A104, A105, A106, A107, A108, A109, A110, A111, A112, A113, A114, A115, A116, A117, A118, A119, A120, A121, A122, A123, A124, A125, A126, A127, A128, A129, A130, A131, A132, A133, A134, A135, A136, A137, A138, A139, A140, A141, A142, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, B11, B12, B13, B14, B15, B16, B17, B18, B19, B20, B21, B22, B23, B24, B25, B26, B27, B28, B29, B30, B31, B32, B33, B34, B35, B36, B37, B38, B39, B40, B41, B42, B43, B44, B45, B46, B47, B48, B49, B50, B51, B52, B53, B54, B55, B56, B57, B58, B59, B60, B61, B62, B63, B64, B65, B66, B67, B68, B69, B70, B71, B72, B73, B74, B75, B76, B77, B78, B79, B80, B81, B82, B83, B84, B85, B86, B87, B88, B89, B90, B91, B92, B93, B94, B95, B96, B97, B98, B99, B100, B101, B102, B103, B104, B105, B106, B107, B108, B109, B110, B111, B112, B113, B114, B115, B116, B117, B118, B119, B120, B121, B122, B123, B124, B125, B126, B127, B128, B129, B130, B131, B132, B133, B134, B135, B136, B137, B138, B139, B140, B141, B142, B143, B144, B145, B146, B147, B148, B149, B150, B151, B152, B153, B154, B155, B156, B157, B158, B159, B160, B161, B162, B163, B164, B165, B166, B167, B168, B169, B170, B171, B172, B173, B174, B175, B176, B177, B178, B179, B180, B181, B182, B183, B184, and B185, or a salt of any thereof.

54. A pharmaceutical composition comprising a compound or salt of any one of claims 1 to 53and a pharmaceutically acceptable excipient.

55. A method of treating a metabolic disease, treating a skeletal muscular condition, inducingweight loss, inducing muscle gain, or increasing basal metabolic rate or resting metabolic rateor active metabolic rate or total daily energy expenditure, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 53 or the pharmaceutical composition of claim 54.

56. The method of claim 55, wherein the method is for treating a metabolic disease is obesity,overweight, morbid obesity, super morbid obesity, pre-diabetes, diabetes, or a metabolic syndrome.

57. The method of claim 55, wherein the method is for treating cardiovascular disease,osteoarthritis, polycystic ovary syndrome, infertility, sleep apnea, breathing problems, asthma, a substance abuse disorder, peripheral vascular disease, venous thromboembolism, fatty liver, high blood pressure, high LDL cholesterol, low HDL cholesterol, high levels of triglycerides, coronary heart disease, gallbladder disease, cancer, mental illness, chronic pain, long COVID, difficulty with physical functioning, stroke, or paralysis.

58. The method of claim 55, wherein the skeletal muscular condition is a neuromuscularcondition, activity-induced muscle damage, a movement disorder, or a metabolic myopathy.

59. The method of claim 58, wherein the method is for treating a neuromuscular conditionselected from Duchenne muscular dystrophy, Becker muscular dystrophy, myotonic dystrophy 1, myotonic dystrophy 2, facioscapulohumeral muscular dystrophy, oculopharyngeal muscular dystrophy, limb girdle muscular dystrophies, tendinitis and carpal tunnel syndrome.

60. The method of claim 58, wherein the method is for treating a movement disorder comprisingspasticity associated with multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, cerebral palsy, injury, stroke, traumatic brain injury, spinal cord injury, hypoxia, meningitis, encephalitis, phenylketonuria, or amyotrophic lateral sclerosis.

61. The method of claim 58, wherein the method is for treating a metabolic myopathy selectedfrom von Gierke’s disease, Anderson disease, Fanconi-Bickel syndrome, aldolase A deficiency, acid maltase deficiency (Pompe disease), carnitine deficiency, carnitine palmitoyltransferase deficiency, debrancher enzyme deficiency (Cori disease, Forbes disease), lactate dehydrogenase deficiency, myoadenylate deaminase deficiency, phosphofructokinase deficiency (Tarui disease), phosphoglycerate kinase deficiency, phosphoglycerate mutase deficiency (Her’s disease), and phosphorylase deficiency (e.g. McArdle’s disease).

62. The method of any one of claims 58 to 61, wherein the skeletal muscular condition iscondition comprises sarcopenia.

63. The method of any one of claims 58 to 62, wherein the skeletal muscular condition comprisesmuscle wasting.

64. The method of any one of claims 58 to 63, wherein the skeletal muscular condition comprisesmuscle spasm.

65. A method of extending the amount of time muscle fibers reside in a DRX state or increasingthe population of muscle fibers residing in the DRX state, the method comprising administering to a patient in need thereof a compound or salt of any one of claims 1 to 53 or the pharmaceutical composition of claim 54.

66. A method of modulating muscle myosin in an individual in need thereof, the methodcomprising administering a therapeutically effective amount of a compound or salt of any one of claims 1 to 53 or the pharmaceutical composition of claim 54.

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