Oral care compositions

Abstract

Oral care compositions and, particularly, prophylaxis pastes providing a whitening effect. In accordance with some aspects, provided is an oral care composition having a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising a stearate and / or acid thereof; and from about 39 to about 73 wt.% of an abrasive, wherein all weight percentages are based on the total weight of the oral care composition.

Description

Docket No. 950817-00- WO-Ol-OCORAL CARE COMPOSITIONSCROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of priority from U.S. Provisional Patent Application No. 63 / 701,636, filed October 1, 2024, the content of which is hereby incorporated herein by reference in its entirety.BACKGROUND

[0002] Teeth can become discolored by foods, drinks, and tobacco use. Dental stains can be classified as either extrinsic, which occur on the outer surface of teeth, or intrinsic, which occur below the surface of enamel.

[0003] Prophylaxis paste or prophy paste is generally a professional product used by dentists during prophylaxis to clean teeth. Prophylaxis is effective at removing tartar and superficial stains during routine examinations or prior to treatments. Prophylaxis pastes typically contain high relative dentine abrasion (RD A) abrasives, such as pumice, and work by removing the top few layers of the tooth surface when used in combination with a high-speed rotary airbrush and rubber cup. Pumice-based pastes are effective at removing surface stains (or chromophores) thus whitening the teeth to a minor degree but are ineffective towards chromophores located deeper below the surface.

[0004] While oxidizing agents may be useful for reducing stains, oxidizing agents are highly reactive and conventionally believed to be unstable in compositions having substantial amounts of abrasives.BRIEF SUMMARY

[0005] This summary is intended merely to introduce a simplified summary of some aspects of one or more implementations of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.

[0006] Aspects of the invention are directed to oral care compositions and, particularly prophylaxis pastes providing a whitening effect. In accordance with some aspects, provided is anDocket No. 950817-00- WO-Ol-OC oral care composition having a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising a stearate and / or acid thereof; and from about 39 to about 73 wt.% of an abrasive, wherein all weight percentages are based on the total weight of the oral care composition.

[0007] In accordance with further aspects, provided is an oral care composition having from about 0.1 to about 10 wt.% of a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising sodium stearate and / or acid thereof; from about 39 to about 73 wt.% of a silica abrasive; and from about 1 wt.% or less of water, wherein all weight percentages are based on the total weight of the oral care composition. Preferably, the oral care compositions are in the form of a prophylaxis paste

[0008] A list of non-limiting embodiments in accordance with aspects of the invention is provided below:

[0009] In an embodiment 1, provided is an oral care composition comprising: a whitening agent comprising a peroxymonosulfate; one or more thickening agent; and from about 39 to about 73 wt.% of an abrasive, wherein all weight percentages are based on the total weight of the oral care composition.

[0010] In an embodiment 2, provided is the oral care composition according to claim 1, wherein the one or more thickening agent comprises a stearate and / or an acid thereof.

[0011] In an embodiment 3, provided is the oral care composition according to claim 2, wherein the stearate and / or the acid thereof comprises sodium stearate.

[0012] In an embodiment 4, provided is the oral care composition according to any foregoing claim, wherein the one or more thickening agent comprises a polyvinyl pyrrolidone.

[0013] In an embodiment 5, provided is the oral care composition according to any foregoing claim, wherein the polyvinyl pyrrolidone has an average molecular weight in the range 5,000 to 100,000.

[0014] In an embodiment 6, provided is the oral care composition according to any foregoing claim, wherein the abrasive is present in an amount from about 42 to about 67 wt.%, optionally from about 45 to about 62 wt.%.

[0015] In an embodiment 7, provided is the oral care composition according to any foregoing claim, wherein the abrasive comprises silica abrasive.

[0016] In an embodiment 8, provided is the oral care composition according to any foregoingDocket No. 950817-00- WO-Ol-OC claim, wherein the abrasive consists of silica abrasive.

[0017] In an embodiment 9, provided is the oral care composition according to any foregoing claim, wherein the whitening agent consists of peroxymonosulfate.

[0018] In an embodiment 10, provided is the oral care composition according to any foregoing claim, wherein the per oxymonosulfate comprises sodium peroxymonosulfate, potassium peroxymonosulfate, or a combination thereof.

[0019] In an embodiment 11, provided is the oral care composition according to any foregoing claim, wherein the peroxymonosulfate is present in an amount from about 0.1 to about 10 wt.%, based on the total weight of the oral care composition.

[0020] In an embodiment 12, provided is the oral care composition according to claim 11, wherein the amount of peroxymonosulfate is from about 0.5 to about 6 wt.%, optionally from about 0.75 to about 3 wt.%.

[0021] In an embodiment 13, provided is the oral care composition according to any foregoing claim, wherein the stearate and / or acid thereof comprises sodium stearate, potassium stearate, zinc stearate, ammonium stearate, stearic acid, or a combination of two or more thereof.

[0022] In an embodiment 14, provided is the oral care composition according to any foregoing claim, wherein the stearate and / or acid thereof is present in an amount from about 3 to about 15 wt.%, based on the total weight of the oral care composition.

[0023] In an embodiment 15, provided is the oral care composition according to any foregoing claim, wherein the oral care composition has a weight ratio of the peroxymonosulfate to the stearate and / or acid thereof of about 1.5:1 to about 1:4.

[0024] In an embodiment 16, provided is the oral care composition according to any foregoing claim, wherein the thickening agent further comprises about 0.1 to about 5 wt.% of silica thickener.

[0025] In an embodiment 17, provided is the oral care composition according to any foregoing claim further comprising: a solvent system comprising a polyoxypropylene -polyoxyethylene block copolymer.

[0026] In an embodiment 18, provided is the oral care composition according to claim 17, wherein the solvent system comprises ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycol-polypropylene glycol copolymer, or a combination ofDocket No. 950817-00- WO-Ol-OC two or more thereof.

[0027] In an embodiment 19, provided is the oral care composition according to claim 17 or claim 18, wherein the solvent system comprises propylene glycol.

[0028] In an embodiment 20, provided is the oral care composition according to claim 19, wherein the propylene glycol is present in an amount from about 5 to about 22 wt.%.

[0029] In an embodiment 21, provided is the oral care composition according to any one of claim 17 to claim 20, wherein the solvent system is present in an amount from about 5 to about 35 wt.%.

[0030] In an embodiment 22, provided is the oral care composition according to any foregoing claim, wherein the oral care composition comprises less than about 3 wt.% of water, based on the total weight of the oral care composition.

[0031] In an embodiment 23, provided is the oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of added water.

[0032] In an embodiment 24, provided is the oral care composition according to any foregoing claim, wherein the abrasive is a substantially spherical amorphous silica abrasive.

[0033] In an embodiment 25, provided is the oral care composition according to any foregoing claim, wherein the oral care composition is a dentifrice.

[0034] In an embodiment 26, provided is the oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of polysaccharides.

[0035] In an embodiment 27, provided is the oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of natural gums.

[0036] In an embodiment 28, provided is the oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of glycerin.

[0037] In an embodiment 29, provided is an oral care composition comprising: from about 0.1 to about 10 wt.% of a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising sodium stearate and / or acid thereof; and from about 39 to about 73 wt.% of a silica abrasive, wherein all weight percentages are based on the total weight of the oral care composition.

[0038] In an embodiment 30, provided is a method for reducing the color of an enamel substrate comprising: applying to any enamel substrate an oral care composition according to any foregoing claim.Docket No. 950817-00- WO-Ol-OCBRIEF DESCRIPTION OF THE DRAWING

[0039] The present invention will become more fully understood from the detailed description and the accompanying drawings, in which:

[0040] FIGURE is a graph of the Fourier transform infrared spectroscopy evaluating the relative presence and absence of silanol (Si-OH) groups and siloxane (-Si-O-Si-) groups in calcined amorphous silica abrasive, dried amorphous silica abrasive, and silica abrasive in accordance with aspects of the invention.

[0041] It should be understood that the various aspects of the invention are not limited to the arrangements and instrumentality shown in the drawings.DETAILED DESCRIPTION

[0042] For illustrative purposes, the principles of the present invention are described by referencing various exemplary embodiments thereof. Although certain embodiments of the invention are specifically described herein, one of ordinary skill in the art will readily recognize that the same principles are equally applicable to, and can be employed in other compositions and methods. Before explaining the disclosed embodiments of the present invention in detail, it is to be understood that the invention is not limited in its application to the details of any particular embodiment disclosed herein. The terminology used herein is for the purpose of description and not of limitation.

[0043] As used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural references unless the context dictates otherwise. The singular form of any class of the ingredients refers not only to one chemical species within that class, but also to a mixture of those chemical species. The terms “a” (or “an”), “one or more” and “at least one” may be used interchangeably herein. The terms “comprising”, “including”, and “having” may be used interchangeably. The term “include” should be interpreted as “include, but are not limited to”. The term “including” should be interpreted as “including, but are not limited to”.

[0044] As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range can be selected as the terminus of the range. Thus, a range from 1-5, includes specifically 1, 2, 3, 4 and 5, as well as subranges such as 2-5, 3-5, 2-3, 2-4, 1-4, etc.Docket No. 950817-00- WO-OLOC

[0045] The term “about” when referring to a number means any number within a range of 10% of the number. For example, the phrase “about 2 wt.%” refers to a number between and including 1.8 wt.% and 2.2 wt.%.

[0046] All references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.

[0047] The abbreviations and symbols as used herein, unless indicated otherwise, take their ordinary meaning. The abbreviation “wt.%” means percent by weight with respect to the oral care composition. The symbol “°” refers to a degree, such as a temperature degree or a degree of an angle. The symbols “h”, “min”, “mL”, “nm”, and “pm” refer to hour, minute, milliliter, nanometer, and micrometer, respectively. The abbreviation “UV-VIS” as referring to a spectrometer or spectroscopy, means Ultraviolet-Visible. The abbreviation “rpm” means revolutions per minute.

[0048] When referring to chemical structures, and names, the symbols “C”, “H”, and “O” mean carbon, hydrogen, and oxygen, respectively. The symbols “=” and “=” mean single bond, double bond, and triple bond, respectively.

[0049] “Volatile”, as used herein, means having a flash point of less than about 100° C. “Nonvolatile”, as used herein, means having a flash point of greater than about 100° C.

[0050] Any member in a list of species that are used to exemplify or define a genus, may be mutually different from, or overlapping with, or a subset of, or equivalent to, or nearly the same as, or identical to, any other member of the list of species. Further, unless explicitly stated, such as when reciting a Markush group, the list of species that define or exemplify the genus is open, and it is given that other species may exist that define or exemplify the genus just as well as, or better than, any other species listed.

[0051] The phrases, “a mixture thereof,” “a combination thereof,” or a combination of two or more thereof’ do not require that the mixture include all of A, B, C, D, E, and F (although all of A, B,C, D, E, and F may be included). Rather, it indicates that a mixture of any two or more of A, B, C,D, E, and F can be included. In other words, it is equivalent to the phrase “one or more elements selected from the group consisting of A, B, C, D, E, F, and a mixture of any two or more of A, B, C, D, E, and F.” Likewise, the term “a salt thereof” also relates to “salts thereof.” Thus, where the disclosure refers to “an element selected from the group consisting of A, B, C, D, E, F, a salt thereof, and a mixture thereof,” it indicates that that one or more of A, B, C, D, and F may beDocket No. 950817-00- WO-Ol-OC included, one or more of a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included, or a mixture of any two of A, B, C, D, E, F, a salt of A, a salt of B, a salt of C, a salt of D, a salt of E, and a salt of F may be included.

[0052] All components and elements positively set forth in this disclosure can be negatively excluded from the claims. In other words, the oral care compositions of the instant disclosure can be free or essentially free of all components and elements positively recited throughout the instant disclosure. In some instances, the oral care compositions of the present disclosure may be substantially free of non-incidental amounts of the ingredient(s) or compound(s) described herein. A non-incidental amount of an ingredient or compound is the amount of that ingredient or compound that is added into the oral care composition by itself. For example, an oral care composition may be substantially free of a non-incidental amount of an ingredient or compound, although such ingredient(s) or compound(s) may be present as part of a raw material that is included as a blend of two or more compounds.

[0053] Some of the various categories of components identified may overlap. In such cases where overlap may exist and the oral care composition includes both components (or the composition includes more than two components that overlap), an overlapping compound does not represent more than one component. For example, certain compounds may be characterized as both a polyol and a sweetener. If a particular oral care composition recites both a polyol and a sweetener, xylitol will serve only as either a polyol or a sweetener — not both.

[0054] For readability purposes, the chemical functional groups are in their adjective form; for each of the adjectives, the word “group” is assumed. For example, the adjective “alkyl” without a noun thereafter, should be read as “an alkyl group.”

[0055] Aspects of the invention are directed to oral care compositions and, particularly prophylaxis pastes providing a whitening effect. In accordance with some aspects, provided is an oral care composition (preferably, a prophylaxis paste) having a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising a stearate and / or acid thereof; and from about 39 to about 73 wt.% of an abrasive, wherein all weight percentages are based on the total weight of the oral care composition.

[0056] In accordance with further aspects, provided is an oral care composition (preferably, a prophylaxis paste) having from about 0.1 to about 10 wt.% of a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising sodium stearate and / or acid thereof;Docket No. 950817-00- WO-Ol-OC from about 39 to about 73 wt.% of a silica abrasive; and from about 1 wt.% or less of water, wherein all weight percentages arc based on the total weight of the oral care composition.

[0057] The oral care compositions may be formulated to have a reduced amount, be substantially free of, or free of added water. For example, the oral care composition may have added water in an amount of about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, or about 0.01 wt.% or less of added water, based on the total weight of the oral care composition. In some embodiments, the oral care compositions have about 0 wt.% or 0 wt.% of added water, based on the total weight of the oral care composition.

[0058] Additionally or alternatively, the oral care compositions may be formulated to have a reduced amount, be substantially free of, or free of water. For example, the total amount of water in the oral care composition may be about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less, based on the total weight of the oral care composition. In some embodiments, the oral care compositions have a total amount of water of about 0 wt.% or 0 wt.%, based on the total weight of the oral care composition.

[0059] The oral care compositions may be in the form of dentifrice, toothpaste, gels, varnishes, leave-on products (e.g., in the form of a gel, varnish, etc.), and / or the like. Suitable components, such as those listed below, may be included or excluded from the formulations for the oral care compositions depending on the specific combination of other ingredients and the form of the oral care compositions. Additionally or alternatively, the oral care compositions may in some embodiments have a single phase, which contains that components and / or ingredients of the oral care composition. In other embodiments, the oral care composition may include two or more phases, such as two, three, four, or five phases. The oral care composition is preferably a prophylaxis paste.

[0060] The oral care compositions typically comprise a whitening agent comprising a peroxymonosulfate. The total amount of whitening agent(s) present in the oral care composition may be from about 0.1 to about 12 wt.%, based on the total weight of the oral care composition. For example, the whitening agent(s) may be present in the oral care composition in an amount from about 0.1 to about 10 wt.%, about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 12 wt.%, about 0.5 to about 10 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5Docket No. 950817-00- WO-Ol-OC to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 12 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%; from about 2 to about 12 wt.%, about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 12 wt.%, about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 7 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 3.5 to about 12 wt.%, about 3.5 to about 10 wt.%, about 3.5 to about 8 wt.%, about 3.5 to about 7 wt.%, about 3.5 to about 6 wt.%, about 3.5 to about 5 wt.%, about 3.5 to about 4 wt.%; from about 4 to about 12 wt.%, about 4 to about 10 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, about 4 to about 6 wt.%; from about 5 to about 12 wt.%, about 5 to about 10 wt.%, about 5 to about 8 wt.%, about 5 to about 7 wt.%; from about 6 to about 12 wt.%, about 6 to about 10 wt.%, about 6 to about 8 wt.%, or any range or subrange thereof, based on the total weight of the oral are composition.

[0061] The whitening agent may comprise from about 0.1 to about 10 wt.% of a peroxymonosulfate, based on the total weight of the oral are composition. The total amount of peroxy mono sulfate in the oral care composition may be from about 0.1 to about 8 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.3 to about 10 wt.%, about 0.3 to about 6 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%, about 0.3 to about 1.5 wt.%, about 0.3 to about 1 wt.%; from about 0.5 to about 10 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1.5 wt.%, about 0.5 to about 1 wt.%; from about 0.75 to about 10 wt.%, about 0.75 to about 6 wt.%, about 0.75 to about 5 wt.%, about 0.75 to about 4 wt.%, about 0.75 to about 3 wt.%, about 0.75 to about 2 wt.%, about 0.75 to about 1.5 wt.%, about 0.75 to about 1 wt.%; from about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%, about 1 to about 1.5 wt.%; from about 2 to about 10 wt.%, about 2 to about 8 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%; from about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 7 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 3.5 to about 10 wt.%, about 3.5 to about 8 wt.%, about 3.5 to about 7 wt.%, about 3.5 to about 6 wt.%, about 3.5 to about 5 wt.%, about 3.5 to about 4 wt.%; from about 4 to about 10 wt.%, about 4 to about 8 wt.%, about 4Docket No. 950817-00- WO-Ol-OC to about 7 wt.%, about 4 to about 6 wt.%; from about 5 to about 10 wt.%, about 5 to about 8 wt.%, about 5 to about 7 wt.%; from about 6 to about 10 wt.%, about 6 to about 8 wt.%, or any range or subrange thereof, based on the total weight of the oral are composition.

[0062] The peroxymonosulfate may be in the form of a salt, such as an alkaline metal salts, alkaline earth metal salts, or mixtures thereof. Examples of such peroxymonosulfate salts that may be included in the oral care composition include sodium peroxymonosulfate, potassium peroxymonosulfate, ammonium peroxymonosulfate, or a combination thereof. The peroxy mono sulfate may be selected from sodium peroxymonosulfate, potassium peroxymonosulfate, and a combination thereof. In some embodiments, the whitening agent(s) consist of one or more peroxymonosulfate(s). In at least one embodiment, the whitening agent(s) consist of one or more of sodium peroxymonosulfate, potassium peroxymonosulfate, and ammonium peroxymonosulfate. The potassium peroxymonosulfate may be combined to form or exist as a triple salt of potassium peroxymonosulfate, potassium hydrogen sulfate, and potassium sulfate (2KHSO5-KHSO4-K2SO4).

[0063] Additional whitening agents that may be included, or sometimes excluded from, the oral care composition include peroxide sources, chlorine dioxide, chlorites, and / or hypochlorites. The peroxide source, which may be included or in some cases excluded, may be chosen from hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, salts thereof, or combinations of two or more thereof. The peroxide source may include peroxides of alkali and alkaline earth metals selected from lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and a combination of two or more thereof. Examples of organic peroxy compounds include carbamide peroxide (also known as urea hydrogen peroxide), glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, monoperoxyphthalate, or a combination of two or more thereof. Peroxy acids and their salts include organic peroxy acids, such as alkyl peroxy acids, monoperoxyphthalate, and a combination thereof, as well as inorganic peroxy acid salts, such as persulfate, dipersulfate, percarbonate, perphosphate, perborate and persilicate salts of alkali and / or alkaline earth metals, such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof. In some embodiments, the peroxide is selected from hydrogen peroxide, lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, alkyl hydrogen peroxides,Docket No. 950817-00- WO-Ol-OC dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, monopcroxyphthalatc, linear PVP complexed with hydrogen peroxide, cross-linked PVP complexed with hydrogen peroxide, silica complexed with hydrogen peroxide, tetrasodium pyrophosphate complexed with hydrogen peroxide, and a combination of two or more thereof. In various embodiments, the peroxide compound comprises hydrogen peroxide, urea peroxide, sodium percarbonate, or a combination of two or more thereof.

[0064] The one or more peroxide(s) may be a non-complexed peroxide or a complexed peroxide. The non-complexed peroxide may be chosen from one or more of the peroxides described above. Peroxide complexes may comprise a peroxide component and a porous cross-linked polymer. As referred to herein, a “peroxide component” is any oxidizing compound comprising a bivalent oxygen-oxygen group. Peroxide components include peroxides and hydroperoxides disclosed above, such as hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, salts thereof, and mixtures thereof. In various embodiments, the peroxide component comprises hydrogen peroxide, urea peroxide, sodium percarbonate and mixtures thereof. The peroxide complex may also be selected from N-vinyl heterocyclic polymers. Preferably, the N-vinyl heterocyclic polymer is crosslinked and adsorbs, absorbs, complexes, or otherwise retains the peroxide component.

[0065] Non-peroxide whitening agents that may be included in, or sometimes excluded from, the oral care composition include chlorine dioxide, chlorites and hypochlorites. Chlorites and hypochlorites include those of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium, and barium.

[0066] In some embodiments, the oral care composition is free or substantially free of non- complexed peroxides. Additionally or alternatively, the oral care composition may be free or substantially free of complexed peroxides. In further embodiments, the oral care composition is free or substantially free of peroxide sources (such as hydrogen peroxide), chlorine dioxide, chlorites and hypochlorites. For instance, the total amount of peroxide sources, chlorine dioxide, chlorites, and hypochlorites in the oral care composition may be about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less, relative to the total weight of the oral care composition. In some embodiments, the oral care compositions have a total amount of peroxide source, chlorine dioxide, chlorites and hypochlorites of about 0 wt.% or 0 wt.%, based on the total weight of the oral careDocket No. 950817-00- WO-Ol-OC composition.

[0067] The oral care composition may be substantially free of or free of ammonium persulfate and sodium persulfate. The oral care composition may have a total amount of about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less of ammonium persulfate and sodium persulfate, based on the total weight of the oral care composition.

[0068] The oral care composition typically comprises one or more thickening agent(s) comprising a fatty acid, a salt thereof, and / or a fatty ester thereof (e.g., a stearate). The total amount of thickening agent(s) in the oral care composition may range from about 0.5 to about 18 wt.%, based on the total weight of the oral care composition. For instance, the total amount of the one or more thickening agent may be from about 0.5 to about 12 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 14 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 14 wt.%, about 1.5 to about 10 wt.%, about 1.5 to about 8 wt.%, about 1.5 to about 6 wt.%, about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2 wt.%; from about 3 to about 15 wt.%, about 3 to about 12 wt.%, about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 5 to about 18 wt.%, about 5 to about 14 wt.%, about 5 to about 12 wt.%, about 5 to about 10 wt.%, about 5 to about 8 wt.%; from about 7 to about 18 wt.%, about 7 to about 14 wt.%, about 7 to about 12 wt.%, about 7 to about 10 wt.%; from about 9 to about 18 wt.%, about 9 to about 14 wt.%, about 9 to about 12 wt.%, from about 10 to about 18 wt.%, about 10 to about 14 wt.%, about 10 to about 12 wt.%; from about 12 to about 18 wt.%, about 12 to about 15 wt.%, about 14 to about 18 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0069] Thickening agents may be referred to as “thickeners” or “viscosity modifying agents.” Thickening agents are typically included to increase the viscosity of the oral care compositions. Nonetheless, in some instances, certain thickening agents provide additional, surprising benefits to the oral care compositions. The one or more thickening agent typically comprises one or more of a fatty acid, a fatty ester thereof, and / or a salt thereof. The one or more fatty acid, fatty ester thereof, and / or salt thereof may be selected from C12-24 fatty acids, C12-22 fatty acids, C12-20 fattyDocket No. 950817-00- WO-Ol-OC acids, C12-I8 fatty acids; from C14-24 fatty acids, C14-22 fatty acids, C14-20 fatty acids, C14-I8 fatty acids; from C16-24 fatty acids, C16-22 fatty acids, C16-20 fatty acids, C16-18 fatty acids, fatty cstcr(s) thereof, and / or a salt(s) thereof.

[0070] In some preferred embodiments, the thickening agents comprise or consist of one or more fatty acid, fatty ester thereof, or salt thereof comprises a stearate and / or an acid thereof. The stearate and / or an acid thereof may comprise potassium stearate, ammonium stearate, zinc stearate, stearic acid, or a combination of two or more thereof. In some instances, the stearate and / or an acid thereof is selected from a salt, such as sodium stearate, potassium stearate, ammonium stearate, zinc stearate, calcium stearate, magnesium stearate, and a combination thereof. In some embodiments, the fatty acid, ester thereof, and / or salt thereof is selected from the group consisting of sodium stearate, potassium stearate, ammonium stearate, zinc stearate, stearic acid, or a combination of two or more thereof. In further embodiments, the fatty acid and / or salt may comprise or consist of sodium stearate and / or stearic acid. In at least one preferred embodiment, the one or more thickening agent comprises or consists of sodium stearate.

[0071] The total amount of fatty acid, fatty ester, and / or salt thereof (e.g., the stearate and / or acid thereof) is preferably present from 0.5 to about 18 wt.%, based on the total weight of the oral care composition. For instance, the total amount of fatty acid(s), fatty ester(s), and / or salt thereof(s) (e.g., the stearate and / or acid thereof) present in the oral care composition may be from about 0.5 to about 12 wt.%, about 0.5 to about 8 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 14 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 1.5 to about 14 wt.%, about 1.5 to about 10 wt.%, about 1.5 to about 8 wt.%, about 1.5 to about 6 wt.%, about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%, about 1.5 to about 2 wt.%; from about 3 to about 15 wt.%, about 3 to about 12 wt.%, about 3 to about 10 wt.%, about 3 to about 8 wt.%, about 3 to about 6 wt.%; from about 5 to about 18 wt.%, about 5 to about 14 wt.%, about 5 to about 12 wt.%, about 5 to about 10 wt.%, about 5 to about 8 wt.%; from about 7 to about 18 wt.%, about 7 to about 14 wt.%, about 7 to about 12 wt.%, about 7 to about 10 wt.%; from about 9 to about 18 wt.%, about 9 to about 14 wt.%, about 9 to about 12 wt.%, from about 10 to about 18 wt.%, about 10 to about 14 wt.%, about 10 to about 12 wt.%; from about 12 to about 18 wt.%, about 12 to about 15 wt.%, about 14 to about 18 wt.%, or any range or subrangeDocket No. 950817-00- WO-Ol-OC thereof, based on the total weight of the oral care composition.

[0072] In at least one embodiment, the oral care composition includes sodium stearate, potassium stearate, ammonium stearate, zinc stearate, stearic acid, or a combination thereof in an amount disclosed above with reference to fatty acid and / or salt thereof.

[0073] The oral care composition may be formulated to have the peroxymonosulfate and fatty acid, fatty ester thereof, and / or salt thereof in certain weight ratios. For instance, the oral care composition may have a weight ratio of the peroxymonosulfate to the fatty acid, fatty ester, and / or salt thereof of about 1.5:1 to about 1:4, about 1.5:1 to about 1:3, about 1.5:1 to about 1:2, about 1.5:1 to about 1:1; from about 1:1 to about 1:4, about 1:1 to about 1:3, about 1:1 to about 1:2; from about 1:1.5 to about 1:4, about 1:1.5 to about 1:3, about 1:1.5 to about 1:2; from about 1:2 to about 1:4, about 1:2 to about 1:3, about 1:3 to about 1:4, or any range or subrange thereof.

[0074] Preferably, the oral care composition is formulated to have the peroxymonosulfate and the stearate and / or acid thereof in certain weight ratios. For instance, the oral care composition may have a weight ratio of the peroxymonosulfate to the stearate and / or acid thereof of about 1.5:1 to about 1:4, about 1.5:1 to about 1:3, about 1.5:1 to about 1:2, about 1.5:1 to about 1:1; from about 1:1 to about 1:4, about 1:1 to about 1:3, about 1:1 to about 1:2; from about 1:1.5 to about 1:4, about 1:1.5 to about 1:3, about 1:1.5 to about 1:2; from about 1:2 to about 1:4, about 1:2 to about 1:3, about 1:3 to about 1:4, or any range or subrange thereof.

[0075] The oral care composition may comprise a thickening system comprising one or more thickening agent(s) other than the stearate and / or acid thereof, such as those selected from a polysaccharide, a silica thickener, an acrylate, acrylate derivatives, a polyacrylic acid, a polyvinyl pyrrolidone, polyitaconates, an acrylamides, a salt there of, and a combination of two or more thereof. Examples of preferred acrylates include poly acrylates, such as Poly acrylate Crosspolymer- 6. Additional examples of preferably thickening agents include Ammonium Acryloyldimethyltaurate / VP Copolymer and 2-acrylamido-2-methylpropane sulfonic acid and N- vinylpyrrolidone.

[0076] Silica thickeners, which form polymeric structures or gels in aqueous media, may be present. Silica thickeners are typically physically and functionally distinct from the particulate silica abrasives as the silica thickeners are very finely divided and provide little or no abrasive action. In certain preferred embodiments, the one or more thickening agent comprises a silica thickener. For instance, the oral care composition may have a thickening system comprising aDocket No. 950817-00- WO-Ol-OC stearate and / or acid thereof and a silica thickener. The silica thickener may comprise a fumed silica. In some embodiments, the one or more thickening agent consists of the stearate and / or acid thereof and, optionally, a silica thickener and / or polyvinyl pyrrolidone. In certain embodiments, the one or more thickening agent consists of the stearate and / or acid thereof and, optionally, a silica thickener. In at least one instance, the thickening system consists of a stearate and / or acid thereof, a silica thickener, or a combination of two or more thereof.

[0077] The one or more thickening agent may include a silica thickener in an amount up to 14 wt.%, based on the total weight of the oral care composition. For instance, the silica thickener may be present in an amount of about 0.1 to about 10 wt.%, about 0.1 to about 7 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.4 to about 7 wt.%, about 0.4 to about 5 wt.%, about 0.4 to about 3 wt.%, about 0.4 to about 2 wt.%, about 0.4 to about 1 wt.%; from about 0.8 to about 10 wt.%, about 0.8 to about 7 wt.%, about 0.8 to about 5 wt.%, about 0.8 to about 3 wt.%, about 0.8 to about 2 wt.%, about 0.8 to about 1.5 wt.%; from about 1.4 to about 14 wt.%, about 1.4 to about 10 wt.%, about 1.4 to about 7 wt.%, about 1.4 to about 5 wt.%, about 1.4 to about 3 wt.%; from about 2 to about 14 wt.%, about 2 to about 10 wt.%, about 2 to about 7 wt.%, about 2 to about 5 wt.%, about 2 to about 3 wt.%; from about 3 to about 14 wt.%, about 3 to about 10 wt.%, about 3 to about 7 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%; from about 4 to about 14 wt.%, about 4 to about 10 wt.%, about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 14 wt.%, about 5 to about 10 wt.%, about 5 to about 7 wt.%, about 5 to about 6 wt.%; from about 7 to about 14 wt.%, about 7 to about 10 wt.%; from about 9 to about 14 wt.%, about 9 to about 10 wt.%; from about 10 to about 14 wt.%, about 10 to about 12 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0078] Additional examples of thickening agents, which may be included or excluded from embodiments of the oral care composition include polysaccharides, such as cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, carrageenan, or a combination of two more thereof. Natural gums such as karaya, gum arabic, and gum tragacanth can also be incorporated. Colloidal magnesium aluminum silicate can also be used as a component of the thickening composition to further improve the composition'sDocket No. 950817-00- WO-Ol-OC texture. For instance, in certain preferred embodiments, the oral care composition is substantially free of or free of cellulose, carboxymethyl hydroxycthylccllulosc, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, carrageenan, and / or polysaccharides as a whole. Additionally, the oral care compositions may be preferably free of karaya, gum arabic, gum tragacanth, and / or natural gum as a whole.

[0079] Polyvinyl pyrrolidone may be included or excluded from certain embodiments of the oral care composition. Polyvinyl pyrrolidone generally refers to a polymer containing vinylpyrrolidone (e.g., N-vinylpyrrolidone, N-vinyl-2-pyrrolidione, and N-vinyl-2-pyrrolidinone) as a monomeric unit. The monomeric unit may include a polar imide group, four non-polar methylene groups, and a non-polar methane group. The polyvinyl pyrrolidone may have an average molecular weight in the range 5,000 to 100,000. The polyvinyl pyrrolidone may be a crosslinked polyvinyl pyrrolidone (crosslinked PVP).

[0080] In some embodiments, the oral care compositions are formulated to have a reduced amount, be substantially free of, or free of polyvinyl pyrrolidone. For example, the oral care composition may have a total amount of about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less of polyvinyl pyrrolidone, based on the total weight of the oral care composition. In some embodiments, the oral care compositions have a total amount of polyvinyl pyrrolidone of about 0 wt.% or 0 wt.%, based on the total weight of the oral care composition.

[0081] Examples of acrylates that may optionally, be included or excluded from the oral care composition, include isobutyl acrylate, tert-butyl acrylate, 2-ethylhexyl acrylate, lauryl acrylate, lauryl / tridecyl acrylate, cetyl acrylate, stearyl acrylate, cyclohexyl acrylate, benzyl acrylate, isobornyl acrylate, 2-methoxyethyl acrylate, 2-ethoxyethyl acrylate, 2-ethoxyethoxyethyl acrylate, 2-phenoxyethyl acrylate, tetrahydrofurfuryl acrylate, 2-hydroxyethyl acrylate, 2-hydroxypropyl acrylate, 4-hydroxybutyl acrylate, dimethylaminoethyl acrylate, 1 ,4-butanediol acrylate, or a combination of two or more thereof. The acrylate may be chosen from diacrylates. In some embodiments, the diacrylate is chosen from 1,4-butanediol, 1 ,6-hexanediol, tetraethylene glycol, tripropylene glycol, ethoxylated bisphenol-A, and a combination of two or more thereof.Docket No. 950817-00- WO-Ol-OCTriacrylate monomers include trimethylol propane, ethoxylated, glyceryl propoxy, and pcntacrythritol.

[0082] Acrylates further include methacrylates, such as methyl methacrylate, ethyl methacrylate, n-butyl methacrylate, isobutyl methacrylate, tert-butyl methacrylate, 2-ethylhexyl methacrylate, lauryl methacrylate, alkyl methacrylate, tridecyl methacrylate, stearyl methacrylate, cyclohexyl methacrylate, benzyl methacrylate, isobornyl methacrylate, 2-hydroxyethyl methacrylate, 2- hydroxypropyl methacrylate, dimethylaminoethyl methacrylate, diethylaminoethyl methacrylate, glycidyl methacrylate, tetrahydrofurfuryl methacrylate, allyl methacrylate, ethylene glycol methacrylate, triethylene glycol methacrylate, tetraethylene glycol methacrylate, 1,3- butyleneglycol methacrylate, 1 ,6-hexanediol methacrylate, trimethylopropane methacrylate, ethoxyethyl methacrylate, trifluoroethyl methacrylate, or a combination of two or more thereof.

[0083] Examples of acrylamides include, but are not limited to, acrylamide, methacrylamide and di(C -C3o) alkyl- acrylamides and -methacrylamides such as those of methyl, ethyl, propyl, butyl, pentyl, hexyl and the like. N-substituted acrylamides that may be suitable include N- ethylacrylamide, N-tert-butylacrylamide, N-tert-octylacrylamide, N-octylacrylamide, N- decylacrylamide, N-dodecylacrylamide and the corresponding N-substituted methacrylamides. Other N-substituted acrylamides include N-hydroxy methyl acrylamide, N-isopropylacrylamide, N-methylacrylamide, N,N'-methylenebisacrylamide, N-isobutoxymethylacrylamide, N,N- dimethylacrylamide, and 2-acrylamido-2-methylpropanesulfonic acid.

[0084] In addition to the one or more whitening agent comprising a peroxymonosulfate and the one or more thickening agent comprising a stearate and / or acid thereof, the oral care composition may comprise at least one solvent. The oral care composition may include 1, 2, 3, 4, 5, 6, 7, or any range or subrange thereof, of solvent(s). For example, the oral care composition may comprise 2 to 7, 2 to 6, 2 to 5, 2 to 5, or 2 to 4; 3 to 7, 3 to 6, 2 to 5, or 3 to 5 solvents. In some cases, the oral care composition has a solvent system comprising a plurality of solvents. The plurality of solvents may be selected from polyols, fatty alcohols, and polyoxypropylene -polyoxyethylene block copolymers. In some embodiments, the oral care composition has a solvent system consisting of one or more polyol, one or more alkoxylated fatty alcohol, and / or one or more polyoxypropylenepolyoxyethylene block copolymer. The solvent system may comprise at least one polyol and at least one polyoxypropylene-polyoxyethylene block copolymer. In some embodiments, the oral care composition has a solvent system consisting of one or more polyol, one or more fatty alcohol,Docket No. 950817-00- WO-Ol-OC and / or one or more polyoxypropylene-polyoxyethylene block copolymer. Tn certain instances, the solvent system comprises at least one polyol and at least one alkoxylatcd fatty alcohol. For example, the oral care composition may have a solvent system consisting of one or more polyol and / or one or more alkoxylated fatty alcohol.

[0085] The total amount of solvent present in the oral care composition may be from about 5 to about 50 wt.%, based on the total weight of the oral care composition. For example, the total amount of solvent(s) in the oral care compositions may have from about 5 to about 40 wt.%, about 5 to about 35 wt.%, about 5 to about 31 wt.%, about 5 to about 28 wt.%, about 5 to about 25 wt.%, about 5 to about 22 wt.%, about 5 to about 19 wt.%; from about 10 to about 35 wt.%, about 10 to about 31 wt.%, about 10 to about 28 wt.%, about 10 to about 25 wt.%, about 10 to about 22 wt.%, about 10 to about 19 wt.%; from about 15 to about 35 wt.%, about 15 to about 31 wt.%, about 15 to about 28 wt.%, about 15 to about 25 wt.%, about 15 to about 22 wt.%, about 15 to about 19 wt.%; from about 25 to about 50 wt.%, about 25 to about 40 wt.%, about 25 to about 35 wt.%, about 25 to about 31 wt.%, about 25 to about 28 wt.%;from about 30 to about 50 wt.%, about 30 to about 40 wt.%, about 30 to about 35 wt.%; from about 35 to about 50 wt.%, about 35 to about 40 wt.%, about 40 to about 50 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0086] The oral care composition, in certain preferred embodiments, comprises a polyoxypropylene-polyoxyethylene block copolymer. The polyoxypropylene-polyoxyethylene block copolymer may have an average molecular weight of about 3,000 to about 20,000 g / mol, about 3,000 to about 17,000 g / mol, about 3,000 to about 15,000 g / mol, about 3,000 to about 13,000 g / mol, about 3,000 to about 11,000 g / mol, about 3,000 to about 9,000 g / mol, about 3,000 to about 7,000 g / mol; from about 6,000 to about 20,000 g / mol, about 6,000 to about 17,000 g / mol, about 6,000 to about 15,000 g / mol, about 6,000 to about 13,000 g / mol, about 6,000 to about 11,000 g / mol, about 6,000 to about 9,000 g / mol; from about 9,000 to about 20,000 g / mol, about 9,000 to about 17,000 g / mol, about 9,000 to about 15,000 g / mol, about 9,000 to about 13,000 g / mol, about 9,000 to about 11,000 g / mol; from about 11,000 to about 20,000 g / mol, about 11,000 to about 17,000 g / mol, about 11,000 to about 15,000 g / mol, about 11,000 to about 13,000 g / mol; from about 13,000 to about 20,000 g / mol, about 13,000 to about 17,000 g / mol, about 13,000 to about 15,000 g / mol; from about 15,000 to about 20,000 g / mol, about 15,000 to about 17,000 g / mol, or any range or subrange thereof.Docket No. 950817-00- WO-Ol-OC

[0087] The amount of polyoxypropylene-polyoxyethylene block copolymer in the oral care composition may be about 4 to about 15 wt.%, based on the total weight of the oral care composition. For example, the polyoxypropylene-polyoxyethylene block copolymer may be present in an amount from about 4 to about 13 wt.%, about 4 to about 11 wt.%, about 4 to about 9 wt.%; from about 6 to about 15 wt.%, about 6 to about 13 wt.%, about 6 to about 11 wt.%, about 6 to about 9 wt.%; from about 8 to about 15 wt.%, about 8 to about 13 wt.%, about 8 to about 11 wt.%; from about 10 to about 15 wt.%, about 10 to about 13 wt.%, or about 12 to about 15 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition. In at least one embodiment, the oral care composition includes about 10 wt.% of polyoxypropylenepolyoxyethylene block copolymer, based on the total weight of the oral care composition.

[0088] The oral care composition, in certain preferred embodiments, comprises one or more alkoxylated fatty alcohol. The alkoxylated fatty alcohol may be selected from Cs-22 alkoxylated fatty alcohols. For instance, the alkoxylated fatty alcohol may be a Cs-22 alkoxylated fatty alcohol, a Cs-20 alkoxylated fatty alcohol, a Cs-is alkoxylated fatty alcohol, a Cs-16 alkoxylated fatty alcohol, a Cs-i4 alkoxylated fatty alcohol, a Cs-i2 alkoxylated fatty alcohol; a C10-22 alkoxylated fatty alcohol, a C10-20 alkoxylated fatty alcohol, a Cio-18 alkoxylated fatty alcohol, a Cio-16 alkoxylated fatty alcohol, a C10-14 alkoxylated fatty alcohol, a C10-12 alkoxylated fatty alcohol; a C12-22 alkoxylated fatty alcohol, a C12-20 alkoxylated fatty alcohol, a C12-I8 alkoxylated fatty alcohol, a C12-16 alkoxylated fatty alcohol, a C12-14 alkoxylated fatty alcohol; a C14-22 alkoxylated fatty alcohol, a C14-20 alkoxylated fatty alcohol, a C14-18 alkoxylated fatty alcohol, a C14-16 alkoxylated fatty alcohol; a C16-22 alkoxylated fatty alcohol, a C16-20 alkoxylated fatty alcohol, a C16-18 alkoxylated fatty alcohol; a C18-22 alkoxylated fatty alcohol, a C18-20 alkoxylated fatty alcohol, or a C20-22 alkoxylated fatty alcohol. The alkoxylated fatty alcohol may be an ethoxylated fatty alcohol. In some embodiments, the alkoxylated fatty alcohol is an ethylene oxide / propyelene oxide / PO addition product.

[0089] The amount of alkoxylated fatty alcohol in the oral care composition may be about 15 wt.% or more, based on the total weight of the oral care composition. For example, the alkoxylated fatty alcohol may be present in an amount from about 15 to about 50 wt.%, about 15 to about 45 wt.%, about 15 to about 40 wt.%, about 15 to about 37 wt.%, about 15 to about 34 wt.%, about 15 to about 31 wt.%, about 15 to about 28 wt.%, about 15 to about 25 wt.%; from about 20 to about 50 wt.%, about 20 to about 45 wt.%, about 20 to about 40 wt.%, about 20 to about 37 wt.%, about 20Docket No. 950817-00- WO-Ol-OC to about 34 wt.%, about 20 to about 31 wt.%, about 20 to about 28 wt.%; from about 25 to about 50 wt.%, about 25 to about 45 wt.%, about 25 to about 40 wt.%, about 25 to about 37 wt.%, about 25 to about 34 wt.%, about 25 to about 31 wt.%; from about 28 to about 50 wt.%, about 28 to about 45 wt.%, about 28 to about 40 wt.%, about 28 to about 37 wt.%, about 28 to about 34 wt.%; from about 30 to about 50 wt.%, about 30 to about 45 wt.%, about 30 to about 40 wt.%, about 30 to about 37 wt.%, about 30 to about 34 wt.%; from about 33 to about 50 wt.%, about 33 to about 45 wt.%, about 33 to about 40 wt.%, about 33 to about 37 wt.%; from about 36 to about 50 wt.%, about 36 to about 45 wt.%; from about 39 to about 50 wt.%, about 39 to about 45 wt.%, about 42 to about 50 wt.%, or any range or subrange thereof.

[0090] Additionally or alternatively, the solvent(s) may be selected from polyols. In some embodiments, the oral care composition has a polyol system comprising a plurality of polyols. The polyol(s) may be chosen from glycols or compounds with numerous hydroxyl groups. The one or more polyols may be liquid at ambient temperature (25°C). Examples of polyols that may be included in, or in some embodiments excluded from, the oral care composition include glycerin, glycol, inositol, maltitol, mannitol, sorbitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), a PEG-PPG copolymer, a saccharide (e.g., fructose, glucose, sucrose and mixtures of saccharides, such as honey), or a combination of two or more thereof. In some preferred embodiments, the one or more polyol(s) comprises ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycolpolypropylene glycol copolymer, or a combination of two or more thereof.

[0091] One or more of the polyols may be a humectant such as, e.g., a glycol, sorbitol, glycerin, inositol, maltitol, mannitol, xylitol, propylene glycol, polypropylene glycol (PPG), polyethylene glycol (PEG), a saccharide (e.g., fructose, glucose, sucrose and mixtures of saccharides, such as honey), and a combination of two or more thereof. Preferably, the oral care composition is substantially free of or free of glycerin and / or diglycerin.

[0092] In some cases, the oral care composition includes or excludes one or more polyol selected from the group consisting of C2-C32 polyols. The one or more polyols may have from 2 to 32 carbon atoms, from 3 to 16 carbon atoms, or from 3 to 12 carbon atoms. For example, the oral care composition may include or exclude one or more of the following polyols: ethylene glycol,Docket No. 950817-00- WO-Ol-OC propylene glycol, butylene glycol, hexylene glycol, diglycerin, diethylene glycol, and dipropylene glycol. Additional, non-limiting examples of polyols that may, optionally, be included in the oral care include and / or may be chosen from alkanediols such as 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 2- butene-l,4-diol, 2-ethyl-l,3-hexanediol, 2-methyl-2,4-pentanediol, caprylyl glycol, 1,2- hexanediol, 1 ,2-pentanediol, and 4-methyl-l,2-pentanediol; glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-propyl ether, ethylene glycol mono-iso-propyl ether, diethylene glycol mono-iso-propyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol mono-t-butyl ether, diethylene glycol mono-t-butyl ether, 1 -methyl- 1 -methoxybutanol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-t-butyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-iso-propyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-propyl ether, dipropylene glycol mono-iso-propyl ether, sorbitol, sorbitan, triacetin, and a mixture of two or more thereof.

[0093] Additionally or alternatively, the oral care composition may include polyol(s) having a molecular weight of from about 100 to 5000 g / mol. For instance, the polyol may comprise a polyethylene glycol, a polypropylene glycol, a block polymer of polyethylene glycol and polypropylene glycol, a polyethylene glycol-polypropylene glycol copolymer, or a combination of two or more thereof. In some embodiments, the polyol comprises a polypropylene glycol, a polypropylene glycol, and / or a block polymer of polyethylene glycol and polypropylene glycol having a molecular weight of about 100 to about 900, about 200 to about 800, about 400, about 1500 to about 2500, about 2000 to about 4500 or any range or subrange thereof. In some embodiments, the polyol is a polyethylene glycol, such as polyethylene glycol 400 or polyethylene glycol 600. In some embodiments, the oral care composition comprises one or more polyethylene glycols, e.g., polyethylene glycols in a molecular weight range from 200 to 800. For example, the compositions may comprise one or more of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol, 600 or polyethylene glycol 800.

[0094] As noted above, the oral care composition may have a polyol system comprising a pluralityDocket No. 950817-00- WO-Ol-OC of polyols. For example, the polyol system may comprise two or more polyols selected from ethylene glycol, propylene glycol, butylene glycol, pcntylcnc glycol, hexylene glycol, dicthylcnc glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycol-polypropylene glycol copolymer, and a combination of two or more thereof. In some preferred embodiments, the polyol system comprises two or more of propylene glycol, a polypropylene glycol (PPG), a polyethylene glycol (PEG), a block copolymer of PPG and PEG, and / or a polyethylene glycol-polypropylene glycol copolymer. The polyol system may comprise propylene glycol, a polyethylene glycol, a polypropylene glycol, a polyethylene glycol- polypropylene glycol copolymer, or a combination of two or more thereof. In at least one embodiment, the polyol system consists of two or more of propylene glycol, a polypropylene glycol (PPG), a polyethylene glycol (PEG), and / or a PEG-PPG copolymer.

[0095] The oral care composition may be formulated to have polyol(s) in an amount of about 15 wt.% or more. For example, the amount of polyol(s) in the oral care composition may be from about 15 to about 50 wt.%, about 15 to about 45 wt.%, about 15 to about 40 wt.%, about 15 to about 37 wt.%, about 15 to about 34 wt.%, about 15 to about 31 wt.%, about 15 to about 28 wt.%, about 15 to about 25 wt.%; from about 20 to about 50 wt.%, about 20 to about 45 wt.%, about 20 to about 40 wt.%, about 20 to about 37 wt.%, about 20 to about 34 wt.%, about 20 to about 31 wt.%, about 20 to about 28 wt.%; from about 25 to about 50 wt.%, about 25 to about 45 wt.%, about 25 to about 40 wt.%, about 25 to about 37 wt.%, about 25 to about 34 wt.%, about 25 to about 31 wt.%; from about 28 to about 50 wt.%, about 28 to about 45 wt.%, about 28 to about 40 wt.%, about 28 to about 37 wt.%, about 28 to about 34 wt.%; from about 30 to about 50 wt.%, about 30 to about 45 wt.%, about 30 to about 40 wt.%, about 30 to about 37 wt.%, about 30 to about 34 wt.%; from about 36 to about 50 wt.%, about 36 to about 45 wt.%, or any range or subrange thereof.

[0096] The oral care composition may be formulated to have about 22 wt.% or less, based on the total weight of the oral care composition, of propylene glycol. For example, the oral care composition may have about 1 to about 22 wt.%, about 1 to about 18 wt.%, about 1 to about 14 wt.%, about 1 to about 12 wt.%, about 1 to about 10 wt.%, about 1 to about 8 wt.%, about 1 to about 7 wt.%; from about 5 to about 22 wt.%, about 5 to about 18 wt.%, about 5 to about 14 wt.%, about 5 to about 12 wt.%, about 5 to about 10 wt.%; from about 10 to about 22 wt.%, about 10 toDocket No. 950817-00- WO-Ol-OC about 18 wt.%, about 13 to about 22 wt.%, about 13 to about 18 wt.%, or any range or subrange thereof, of propylene glycol, based on the total weight of the oral care composition.

[0097] The oral care compositions typically include one or more abrasive in an amount from about 39 to about 73 wt.%, based on the total weight of the oral care composition. In some embodiments, the one or more abrasive(s) is present in an amount from about 39 to about 73 wt.%, about 39 to about 67 wt.%, about 39 to about 65 wt.%, about 39 to about 60 wt.%, about 39 to about 56 wt.%, about 39 to about 52 wt.%, about 39 to about 48 wt.%, about 39 to about 44 wt.%; from about 42 to about 73 wt.%, about 42 to about 67 wt.%, about 42 to about 65 wt.%, about 42 to about 60 wt.%, about 42 to about 56 wt.%, about 42 to about 52 wt.%; from about 45 to about 73 wt.%, about 45 to about 67 wt.%, about 45 to about 65 wt.%, about 45 to about 60 wt.%, about 45 to about 56 wt.%, about 45 to about 52 wt.%; from about 48 to about 73 wt.%, about 48 to about 67 wt.%, about 48 to about 65 wt.%, about 48 to about 60 wt.%, about 48 to about 56 wt.%, about 48 to about 52 wt.%; from about 53 to about 73 wt.%, about 53 to about 67 wt.%, about 53 to about 65 wt.%, about 53 to about 60 wt.%; from about 58 to about 73 wt.%, about 58 to about 67 wt.%, about 63 to about 73 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0098] The one or more abrasive(s) may be chosen from silica, silicate, silicon, alumina (including calcined aluminum oxide), aluminosilicates, such as bentonite, zeolite, kaolin, and mica, siliceous or diatomaceous earth, pumice, calcium compounds, calcium carbonate, cuttlebone, insoluble phosphates, composite resins, such as melamine resin, phenolic resin, and urea-formaldehyde resin, polycarbonate, silicon carbide, boron carbide, microcrystalline wax, microcrystalline cellulose, including combinations of colloidal microcrystalline cellulose and carboxymethylcellulose, and combinations and derivatives thereof. For example, the one or more abrasive may be selected from silicas including gels and precipitates, calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, hydrated alumina, resinous abrasive materials such as particulate condensation products of urea and formaldehyde, and combinations thereof.

[0099] In certain embodiments, the one or more abrasive comprises an insoluble phosphate salts, such as calcium pyrophosphate, dicalcium orthophosphate dihydrate, tricalcium phosphate, calcium polymetaphosphate, or a combination of two or more thereof. As used herein, “mica”Docket No. 950817-00- WO-Ol-OC refers to any of a group of hydrous aluminum silicate minerals with plate morphology and / or perfect basal (micaceous) cleavage. Mica can be, for example, sheet mica, scrap mica or flake mica, as exemplified by muscovite, biotite or phlogopite type micas. Additional abrasives include precipitated calcium carbonate (PCC), natural calcium carbonate (NCC), and limestone.

[0100] Preferably, the one or more abrasive comprises a silica abrasive. In certain embodiments, the one or more abrasive consists of silica abrasives. In other words, in certain embodiments, the oral care composition includes silica abrasives as the only abrasive in the oral care composition. The silica abrasive may be selected from calcinated silica abrasives. For example, the silica abrasive may be a calcinated amorphous silica abrasive. In certain preferred embodiments, the silica abrasive is substantially free of or free of Si-OzSi-OH bonds on the surface of the silica, e.g., as measured using Fourier transform infrared spectroscopy. The silica abrasive may be a calcinated silica abrasive that has a surface that is substantially free of or free of Si-O‘zSi-OH, e.g., as measured using Fourier transform infrared spectroscopy.

[0101] The oral care composition may be formulated such that calcinated amorphous silica abrasive(s) and / or silica abrasive(s) that has a surface that is substantially free of or free of Si-O"zSi-OH (e.g., as measured using Fourier transform infrared spectroscopy) are the predominant abrasive(s) in the oral are composition. For example, calcinated amorphous silica abrasive(s) and / or silica abrasive(s) that has a surface that is substantially free of or free of Si-OzSi-OH (e.g., as measured using Fourier transform infrared spectroscopy) may be about 65 wt.% or more, about 70 wt.% or more, about 77 wt.% or more, about 84 wt.% or more, about 91 wt.% or more, about 94 wt.% or more, about 97 wt.% or more, or about 99 wt.% or more, of the total amount of abrasives in the oral care composition. Preferably, the total amount of calcinated amorphous silica abrasive(s) and / or silica abrasive(s) that has a surface that is substantially free of or free of Si-O'zSi-OH (e.g., as measured using Fourier transform infrared spectroscopy) are about 82 wt.% or more, about 89 wt.% or more about 94 wt.% or more, about 97 wt.% or more, or about 99 wt.% or more, of the total amount of abrasives in the oral care composition. In at least one preferred embodiment, the oral care composition has abrasives consisting of those selected from calcinated amorphous silica abrasive(s) and / or silica abrasive(s) that has a surface that is substantially free of or free of Si-OzSi-OH.

[0102] Synthetic silica abrasives include both silica gels and precipitated silicas that are prepared by the neutralization of aqueous silicate solutions with a strong mineral acid. The silica may be anDocket No. 950817-00- WO-Ol-OC amorphous silica that is spherical or substantially spherical, a prophy silica, and / or a high cleaning silica. Prophy silicas generally refer to a silica that diminishes in particle size, c.g., during use of the oral are composition. In certain embodiments, the oral compositions may comprise a particularly efficacious combination of silica abrasive particle species. For example, the abrasive(s) be selected from high cleaning silica.

[0103] The oral care compositions may include an abrasive system comprising two or more abrasives. For example, an abrasive system comprises 2 to 7, 2 to 6, 2 to 5, 2 to 5, or 2 to 4; 3 to 7, 3 to 6, 2 to 5, or 3 to 5 abrasives. The abrasives may comprise one or more cleaning abrasive and / or one or more polishing abrasives. As appreciated by one of skill in the art, a single abrasive species typically performs at least some cleaning and polishing simultaneously. However, particles are generally categorized in the art by the predominant effect they have on a target oral surface. Typically, “polishing abrasives” are considered to be relatively small particles having high hardness, where abrasives with relatively large particle sizes and low hardness are considered to be “cleaning abrasives.” An example of a useful polishing abrasive is spherical or substantially spherical amorphous silica.

[0104] In certain embodiments, the oral care composition comprises two or more abrasives comprising silica. In some embodiments, the first abrasive is selected to be a harder and smaller abrasive, e.g., a higher cleaning and / or polishing abrasive, and the second abrasive is a typical cleaning abrasive. In some embodiments, the oral care composition includes at least one polishing abrasive and / or at least one cleaning abrasive. Further examples of abrasives are disclosed in U.S. Patent Publication No. 2007 / 140986, which is incorporated herein in its entirety by reference for all purposes.

[0105] The oral care compositions may include one or more nonionic surfactants. The nonionic surfactant may be an alkoxylated fatty alcohol, including any of the alkoxylated fatty alcohols disclosed above. Examples of nonionic surfactants other than alkoxylated fatty alcohols include polyoxyethylene sorbitan esters, polyoxyl 40 hydrogenated castor oil, long chain tertiary amine oxides, long chain tertiary phosphaine oxides, lauryl glucoside, and long chain dialkyl sulfoxides. Suitable nonionic surfactants with a HLB of 7 or more include sucrose laurate, sucrose cocoate, sucrose stearate; Steareth 20, 21, or 100, and PEG 20 Sorbitan Monostearate (commercially available as Tween 60). In at least one embodiment, the nonionic surfactants are chosen from polyethoxylated sorbitol esters, in particular polyethoxylated sorbitol monoesters;Docket No. 950817-00- WO-Ol-OC polycondensates of ethylene oxide and propylene oxide (poloxamers); condensates of propylene glycol; polycthoxylatcd hydrogenated castor oil, for instance, crcmophors; and sorbitan fatty esters.

[0106] The amount of nonionic surfactants (e.g., nonionic surfactants other than alkoxylated fatty alcohols) may be from about 0.1 to about 8 wt.%, about 0.1 to about 7 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; from about 0.5 to about 8 wt.%, about 0.5 to about 7 wt.%, about 0.5 to about 6 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 4 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%; from about 1 to about 9 wt.%, about 1 to about 8 wt.%, about 1 to about 7 wt.%, about 1 to about 6 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 9 wt.%, about 2 to about 8 wt.%, about 2 to about 7 wt.%, about 2 to about 6 wt.%, about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 2.5 to about 9 wt.%, about 2.5 to about 8 wt.%, about 2.5 to about 7 wt.%, about 2.5 to about 6 wt.%, about 2.5 to about 5 wt.%, about 2.5 to about 4 wt.%, about 2.5 to about 3.5 wt.%; from about 3 to about 9 wt.%, about 3 to about 8 wt.%, about 3 to about 7 wt.%, about 3 to about 6 wt.%, about 3 to about 5 wt.%, about 3 to about 4 wt.%, about 3 to about 3.5 wt.%; from about 4 to about 9 wt.%, about 4 to about 8 wt.%, about 4 to about 7 wt.%, about 4 to about 6 wt.%, about 4 to about 5 wt.%; from about 5 to about 9 wt.%, about 5 to about 8 wt.%, about 5 to about 7 wt.%, about 5 to about 6 wt.%; from about 7 to about 9 wt.%, about 7 to about 8 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0107] The nonionic surfactant(s) may, in some cases, be present in an amount from about 15 to about 50 wt.%, based on the total weight of the oral care composition. For instance, the nonionic surfactant(s) may be present in the oral care composition in an amount from about 15 to about 45 wt.%, about 15 to about 40 wt.%, about 15 to about 37 wt.%, about 15 to about 34 wt.%, about 15 to about 31 wt.%, about 15 to about 28 wt.%, about 15 to about 25 wt.%; from about 20 to about 50 wt.%, about 20 to about 45 wt.%, about 20 to about 40 wt.%, about 20 to about 37 wt.%, about 20 to about 34 wt.%, about 20 to about 31 wt.%, about 20 to about 28 wt.%; from about 25 to about 50 wt.%, about 25 to about 45 wt.%, about 25 to about 40 wt.%, about 25 to about 37 wt.%, about 25 to about 34 wt.%, about 25 to about 31 wt.%; from about 28 to about 50 wt.%, about 28 to about 45 wt.%, about 28 to about 40 wt.%, about 28 to about 37 wt.%, about 28 to about 34 wt.%; from about 30 to about 50 wt.%, about 30 to about 45 wt.%, about 30 to about 40 wt.%,Docket No. 950817-00- WO-Ol-OC about 30 to about 37 wt.%, about 30 to about 34 wt.%; from about 33 to about 50 wt.%, about 33 to about 45 wt.%, about 33 to about 40 wt.%, about 33 to about 37 wt.%; from about 36 to about 50 wt.%, about 36 to about 45 wt.%; from about 39 to about 50 wt.%, about 39 to about 45 wt.%, about 42 to about 50 wt.%, or any range or subrange thereof.

[0108] Anionic and / or cationic surfactants may be included in the oral care composition. The oral care composition may include one or more anionic surfactants selected from sulfate based anionic surfactants, sulfonated monoglycerides of fatty acids, acyl isethionates, acyl sarcosinates, acyl taurate, or combinations of two or more thereof. Examples of sulfate based anionic surfactants include ammonium lauryl sulfate, ammonium lauryl ether sulfate, sodium dodecyl sulfate, sodium coco-sulfate, ammonium coco-sulfate, or a combination of two or more thereof. The one or more anionic surfactant(s) may be selected from non-sulfate based anionic surfactants, such as sulfonated monoglycerides of fatty acids, acyl isethionates, acyl sarcosinates, acyl taurate, or a combination of two or more thereof. For example, the anionic surfactants may be selected from water-soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids; sodium N- methyl N-cocoyl taurate; sodium cocomo-glyceride sulfate; higher alkyl sulfates, such as sodium lauryl sulfate; higher alkyl-ether sulfates, such as sodium laureth-2 sulfate; higher alkyl aryl sulfonates, such as sodium dodecyl benzene sulfonate (sodium lauryl benzene sulfonate); higher alkyl sulfoacetates, such as sodium lauryl sulfoacetate (dodecyl sodium sulfoacetate), higher fatty acid esters of 1,2 dihydroxy propane sulfonate, sulfocolaurate (N-2- ethyl laurate potassium sulfoacetamide) and sodium lauryl sarcosinate.

[0109] The oral care composition may include the anionic surfactants, if present, in an amount from about 0.1 to about 5 wt.%, based on the total weight of the oral care composition. For example, the total amount of anionic surfactant(s) may be from about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; from about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%; from about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about 3 wt.%, about 0.6 to about 2 wt.%; from about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%; from about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2Docket No. 950817-00- WO-Ol-OC to about 3 wt.%; from about 3 to about 5 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0110] Non-limiting examples of amphoteric surfactants include, e.g., long chain imidazoline derivatives such as the product marketed under the trade name ' Miranol C2M' by Miranol; long chain alkyl betaines, such as the product marketed under the tradename 'Empigen BB' by Albright+Wilson, and long chain alkyl amidoalkyl betaines, such as cocamidopropylbetaine, and mixtures thereof.

[0111] The oral care composition may include amphoteric surfactants chosen from derivatives of aliphatic secondary and tertiary amines, in which the aliphatic radical can be a straight chain or branched and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic water-solubilizing group, such as carboxylate, sulfonate, sulfate, phosphate, or phosphonate. Other exemplary amphoteric surfactants are betaines, such as cocamidopropyl betaine, lauryl dimethyl betaine (sold under the trade name Macat LB), cetyl dimethyl betaine, and cocoamphodiacetate. Additional amphoteric surfactants and nonionic surfactants can be found in U.S. Pat. No. 4,051,234, which is incorporated herein in its entirety for all purposes.

[0112] The amount of amphoteric surfactants present in the oral care composition may be from about 0.1 to about 5 wt.%, based on the total weight of the oral care composition. For example, the total amount of amphoteric surfactant(s) may be from about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; from about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%; from about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about 3 wt.%, about 0.6 to about 2 wt.%; from about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%; from about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 5 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0113] The oral care composition may include one or more cationic surfactant(s). Examples of cationic surfactants that may be present or excluded from the oral care composition include cetyl pyridinium chloride, coamidopropyl PG dimonium chloride phosphate (Phospholipid CDM),Docket No. 950817-00- WO-Ol-OC myristylamidopropyl PG dimonium chloride phosphate (Phospholipid PTM), stearamidopropyl PG dimonium chloride phosphate (Phospholipid SV), stcapyrium chloride (Catcmol WPC), and other suitable cationic materials. The cationic surfactants may be D,L-2-pyrrolidone-5 -carboxylic.

[0114] The cationic surfactant(s), if present, may be in an amount of from about 0.1 to about 5 wt.%, based on the total weight of the oral care composition. For example, the total amount of amphoteric surfactant(s) may be from about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; from about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%; from about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about 3 wt.%, about 0.6 to about 2 wt.%; from about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%; from about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 5 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0115] The oral care composition may comprise an anti-calculus agent, e.g., in an effective amount. In some embodiments, the amount of anti-calculus agent present in the oral care composition is from about 0.1 to about 7 wt.%, about 0.1 to about 6 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2.7 wt.%, about 0.1 to about 2.4 wt.%, about 0.1 to about 2.1 wt.%, about 0.1 to about 1.7 wt.%, about 0.1 to about 1.4 wt.%, about 0.1 to about 1.1 wt.%; from about 0.5 to about 7 wt.%, about 0.5 to about 5 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2.7 wt.%, about 0.5 to about 2.4 wt.%, about 0.5 to about 2.1 wt.%, about 0.5 to about 1.7 wt.%, about 0.5 to about 1.4 wt.%, about 0.5 to about 1.1 wt.%; from about 1 to about 7 wt.%, about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2.7 wt.%, about 1 to about 2.4 wt.%, about 1 to about 2.1 wt.%, about 1 to about 1.7 wt.%; from about 1.3 to about 7 wt.%, about 1.3 to about 5 wt.%, about 1.3 to about 4 wt.%, about 1.3 to about 3 wt.%, about 1.3 to about 2.7 wt.%, about 1.3 to about 2.4 wt.%, about 1.3 to about 2.1 wt.%, about 1.3 to about 1.7 wt.%; from about 1.6 to about 7 wt.%, about 1.6 to about 5 wt.%, about 1.6 to about 4 wt.%, about 1.6 to about 3 wt.%, about 1.6 to about 2.7 wt.%, about 1.6 to about 2.4 wt.%, about 1.6 to about 2.1 wt.%; from about 1.9 to about 7Docket No. 950817-00- WO-Ol-OC wt.%, about 1 .9 to about 5 wt.%, about 1 .9 to about 4 wt.%, about 1 .9 to about 3 wt.%, about 1 .9 to about 2.7 wt.%, about 1.9 to about 2.4 wt.%; from about 2.4 to about 7 wt.%, about 2.4 to about 6 wt.%, about 2.4 to about 5 wt.%, about 2.4 to about 4 wt.%, about 2.4 to about 3 wt.%, about 2.4 to about 2.7 wt.%; from about 2.7 to about 7 wt.%, about 2.7 to about 6 wt.%, about 2.7 to about 5 wt.%, about 2.7 to about 4 wt.%; from about 3.3 to about 7 wt.%, about 3.3 to about 6 wt.%, about 3.3 to about 5 wt.%, about 3.3 to about 4 wt.%, from about 3.9 to about 7 wt.%, about 3.9 to about 6 wt.%, about 3.9 to about 5 wt.%; from about 4.6 to about 7 wt.%, about 4.6 to about 6 wt.%, about 4.6 to about 5 wt.%; from about 5.5 to about 7 wt.%, about 5.5 to about 6.5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0116] The anti-calculus agent(s) may be chosen from phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates, and combinations of two or more thereof. Examples of anti-calculus agents include tetrasodium pyrophosphate, ammonium tripolyphosphate, hexametaphosphate salt, polycarboxylate polymers, polyvinyl methyl ether / maleic anhydride (PVME / MA) copolymers, or combinations of two or more thereof.

[0117] The anti-calculus agent may comprise, or in some cases consist of, polyphosphates selected from pyrophosphates, orthophosphates, polymetaphosphates, and a combination of two or more thereof. The polyphosphate may comprise a pyrophosphate, such as an alkali metal pyrophosphate selected from a tetra alkali metal pyrophosphate, dialkali metal diacid pyrophosphate, trialkali metal monoacid pyrophosphate, and mixtures thereof. The alkali metals may be sodium and / or potassium. For example, the polyphosphate may be an alkali metal polyphosphate selected from a pyrophosphate, a tripolyphosphate, a tetraphosphate, a hexametaphosphate, and a combination thereof. In some embodiments, the polyphosphate is selected from sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, potassium tripolyphosphate, or a combination thereof. In further embodiments, the polyphosphate comprises tetrasodium pyrophosphate, tetrapotassium pyrophosphate, sodium tripolyphosphate, tetrapolyphosphate, sodium trimetaphosphate, sodium hexametaphosphate, potassium polyphosphate, sodium polyphosphate, or a combination of two or more thereof.

[0118] The oral care compositions may include a fluoride ion source. The fluoride ion source may be present in an effective amount. In some cases, the fluoride ion source is present in the oral careDocket No. 950817-00- WO-Ol-OC composition in an amount of about 0.01 to about 5 wt.%, based on the total weight of the oral care composition. For example, the fluoride ion source is present in an amount of about 0.01 to about 5 wt.%, about 0.01 to about 4 wt.%, about 0.01 to about 3 wt.%, about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%; from about 0.05 to about 5 wt.%, about 0.05 to about 4 wt.%, about 0.05 to about 3 wt.%, about 0.05 to about 2 wt.%, about 0.05 to about 1 wt.%; from about 0.1 to about 5 wt.%, about 0.1 to about 4 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%; from about 0.3 to about 5 wt.%, about 0.3 to about 4 wt.%, about 0.3 to about 3 wt.%, about 0.3 to about 2 wt.%; from about 0.6 to about 5 wt.%, about 0.6 to about 4 wt.%, about 0.6 to about 3 wt.%, about 0.6 to about 2 wt.%; from about 0.9 to about 5 wt.%, about 0.9 to about 4 wt.%, about 0.9 to about 3 wt.%, about 0.9 to about 2 wt.%; from about 1.2 to about 5 wt.%, about 1.2 to about 4 wt.%, about 1.2 to about 3 wt.%, about 1.2 to about 2 wt.%; from about 1.5 to about 5 wt.%, about 1.5 to about 4 wt.%, about 1.5 to about 3 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about 2 to about 3 wt.%; from about 3 to about 5 wt.%, about 4 to about 5 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0119] The fluoride ion source may be selected from soluble fluoride ion salts. For example, the fluoride ion source may comprise sodium fluoride, potassium fluoride, calcium fluoride, zinc fluoride, zinc ammonium fluoride, lithium fluoride, ammonium fluoride, stannous fluoride, stannous fluorozirconate, sodium monofluorophosphate, potassium monofluorophosphate, laurylamine hydrofluoride, diethylaminoethyloctoylamide hydrofluoride, didecyldimethylammonium fluoride, cetylpyridinium fluoride, dilaurylmorpholinium fluoride, sarcosine stannous fluoride, glycine potassium fluoride, glycine hydrofluoride, amine fluorides or a combination of two or more thereof. In some embodiments, the fluoride ion source comprises sodium fluoride, sodium monofluorophosphate, or a combination thereof.

[0120] In certain embodiments, the oral care composition of the disclosure may contain a source of fluoride ions or fluorine-providing agents in amounts sufficient to deliver, in total, from 25 ppm to 25,000 ppm (mass fraction) of fluoride ions, generally at least 500 ppm, e.g., from about 500 to about 2000 ppm, from about 800 to about 1800 ppm, from about 1000 to about 1600 ppm, from about 1200 to about 1550 ppm, or about 1450 ppm.

[0121] In some embodiments, the oral care compositions may include one or more sweeteners. The oral care composition may include caloric sweeteners and / or non-caloric sweeteners. Examples of non-caloric sweeteners include saccharin, for example, sodium saccharin,Docket No. 950817-00- WO-Ol-OC acesulfame, neotame, cyclamate or sucralose; natural high-intensity sweeteners, such as thaumatin, stcviosidc or glycyrrhizin; or sugar alcohols, such as sorbitol, xylitol, maltitol and mannitol. Examples of caloric sweeteners include sugars, such as fructose, glucose, sucrose, and high fructose syrups.

[0122] The one or more sweetener(s) may be present in the oral care composition in an amount from about 0.1 to about 50 wt.%, based on the total weight of the oral care composition. For example, the oral care composition may have a total amount of sweetener(s) from about 0.1 to about 40 wt.%, about 0.1 to about 30 wt.%, about 0.1 to about 20 wt.%, about 0.1 to about 10 wt.%, about 0.1 to about 5 wt.%, about 0.1 to about 3 wt.%; from about 1 to about 50 wt.%, about 1 to about 40 wt.%, about 1 to about 30 wt.%, about 1 to about 20 wt.%, about 1 to about 10 wt.%, about 1 to about 5 wt.%, about 1 to about 3 wt.%; from about 5 to about 50 wt.%, about 5 to about 40 wt.%, about 5 to about 30 wt.%, about 5 to about 20 wt.%, about 5 to about 10 wt.%; from about 10 to about 50 wt.%, about 10 to about 45 wt.%, about 10 to about 40 wt.%, about 10 to about 35 wt.%, about 10 to about 30 wt.%, about 10 to about 25 wt.%; from about 15 to about 50 wt.%, about 15 to about 45 wt.%, about 15 to about 40 wt.%, about 15 to about 37 wt.%, about 15 to about 34 wt.%, about 15 to about 31 wt.%, about 15 to about 28 wt.%, about 15 to about 25 wt.%; from about 20 to about 50 wt.%, about 20 to about 45 wt.%, about 20 to about 40 wt.%, about 20 to about 37 wt.%, about 20 to about 34 wt.%, about 20 to about 31 wt.%, about 20 to about 28 wt.%; from about 25 to about 50 wt.%, about 25 to about 45 wt.%, about 25 to about 40 wt.%, about 25 to about 37 wt.%, about 25 to about 34 wt.%, about 25 to about 31 wt.%; from about 28 to about 50 wt.%, about 28 to about 45 wt.%, about 28 to about 40 wt.%, about 28 to about 37 wt.%, about 28 to about 34 wt.%, about 28 to about 31 wt.%; from about 31 to about 50 wt.%, about 31 to about 45 wt.%, about 31 to about 40 wt.%, about 31 to about 37 wt.%; from about 34 to about 50 wt.%, about 34 to about 45 wt.%, about 34 to about 40 wt.%; from about 37 to about 50 wt.%, about 37 to about 45 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition.

[0123] In some embodiments, the oral care composition preferably is substantially free or free of caloric sweeteners. For example, the oral care compositions may have about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, or about 0.1 wt.% or less of caloric sweeteners, based on the weight of the oral care composition. In at least one embodiment, the oral care composition contains about 0 wt.% or 0 wt.% of caloric sweeteners,Docket No. 950817-00- WO-Ol-OC based on the weight of the oral care composition.

[0124] The oral care compositions of the present disclosure may include a flavoring agent. The flavoring agent is typically incorporated in the oral care composition at a concentration of about 0.01 to about 3 wt.% by weight of the oral care composition. For example, the amount of flavoring agent(s) present in the oral care composition may be from about 0.01 to about 2 wt.%, about 0.01 to about 1 wt.%, about 0.01 to about 0.5 wt.%, about 0.01 to about 0.1 wt.%; from about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%, about 0.1 to about 0.5 wt.%; from about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 3 wt.%, including any range or subrange thereof, based on the total weight of the oral care composition.

[0125] Suitable flavoring agents include, but are not limited to, essential oils and various flavoring aldehydes, esters, alcohols, and similar materials. Examples of the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethole. Additional flavoring agents may include, but are not limited to menthol, artificial vanilla, cinnamon derivatives, and various fruit flavors, spearmint oil, peppermint oil, cinnamon oil, oil of wintergreen (methylsalicylate), clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, oil of bitter almonds, cassia oil, and a combination of two or more thereof.

[0126] The oral care compositions may include one or more colorants. Exemplary colorants can include natural or uncertified colors from natural sources or certified colors for the effect of color. In some embodiments, the colorant can include dyes, certified aluminum lakes or colors derived from a natural source. The colorant may be water-based, oil-based or dry. Additional colorants include pigments, such as titanium dioxide, zinc oxide, or the like. The colorants can be primary colors, blends of colors or discrete mixtures of colors, such as confetti. The concentrations of the colorant in the oral care composition may be from trace amount to about 0.6 wt.%, from about 0.1 to about 0.5 wt.%, about 0.2 to about 0.4 wt.%, or about 0.15 to about 0.35 wt.%, based on the total weight of the oral care composition.

[0127] The oral care composition may include one or more pH adjusters to increase or decrease the overall pH of the oral care composition. For example, one or more acids may be included to decrease the pH of the oral care composition. Examples of suitable acids for decreasing the pH ofDocket No. 950817-00- WO-Ol-OC the oral care composition include, but are not limited to, citric acid, acetic acid, sodium acid pyrophosphate, and the like. The oral care composition may include one or more bases, such as sodium hydroxide, potassium hydroxide and the like, to increase the pH of the oral care composition. Additional or alternative acids and bases that are suitable for adjusting the pH of the oral care composition are readily known to one of ordinary skill in the art.

[0128] The amount of the pH adjuster in the oral care composition may be based on the desired pH of the final oral care composition and / or product. For example, the total amount of the pH adjuster may range from about 0.05 to about 20 wt.%, based on the total weight of the oral care composition. In some instances, the total amount of pH adjuster is from about 0.05 to about 15 wt.%, about 0.1 to about 10 wt.%, or about 0.12 to about 5 wt.%, including ranges and sub-ranges therebetween, based on the total weight of the oral care composition.

[0129] The oral care compositions may have a pH from about 4.5 to about 10, 4.5 to about 9, about 4.5 to about 8, about 4.5 to about 7, about 4.5 to about 6; from about 5 to about 10, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6; from about 6 to about 10, about 6 to about 9, about 6 to about 8, or about 6 to about 7; from about 7 to about 10, about 7 to about 9, or about 7 to about 8, including any ranges and subranges therebetween, e.g., as measured as a 10 wt.% solution. The pH of the solution (e.g., any of the foregoing pH ranges) may be measured as a 10 wt.% solution, whereby the solution comprises 10 wt.% of the oral care composition with the remainder being water.

[0130] As discussed above, the oral care compositions may have reduced amount of water. In some cases, the oral care compositions have water in an amount up to about 5 wt.%, up to about 4 wt.%, up to about 3 wt.%, up to about 2 wt.%, up to about 1 wt.%, up to about 0.5 wt.%, up to about 0.1 wt.%; from about 0.1 to about 5 wt.%, about 0.1 to about 3 wt.%, about 0.1 to about 2 wt.%, about 0.1 to about 1 wt.%; from about 0.5 to about 5 wt.%, about 0.5 to about 3 wt.%, about 0.5 to about 2 wt.%, about 0.5 to about 1 wt.%; from about 1 to about 5 wt.%, about 1 to about 4 wt.%, about 1 to about 3 wt.%, about 1 to about 2 wt.%; from about 2 to about 5 wt.%, about 2 to about 4 wt.%, about to about 3 wt.%; from about 3 to about 5 wt.%, about 3 to about 4 wt.%, or any range or subrange thereof, based on the total weight of the oral care composition. In some embodiments, however, the oral care composition may have a total amount of about 5 wt.% or less, about 4 wt.% or less, about 3 wt.% or less, about 2 wt.% or less, about 1 wt.% or less, about 0.5 wt.% or less, about 0.1 wt.% or less, about 0.05 wt.% or less, or about 0.01 wt.% or less ofDocket No. 950817-00- WO-Ol-OC added water, based on the total weight of the oral care composition. The oral care compositions may, in some instances, have a total amount of water of about 0 wt.% or 0 wt.%, based on the total weight of the oral care composition.EXAMPLESExample 1

[0131] Two non-limiting example oral care composition (Example Compositions A and B) were prepared in the form of a prophylaxis dentifrice in accordance with aspects of the invention. A comparative oral care composition (Comparative Composition 1) was also prepared in the form of a prophylaxis dentifrice. The formulations of Example Composition A and Comparative Composition 1 are shown in Table 1.Table 1Example 2

[0132] Example Composition A was subjected to accelerated aging conditions to evaluate the stability of the peroxymonosulfate. Specifically, a sample of Example Composition A was kept at a temperature of 60° C for 1 week. The active oxygen level of Example Composition A was evaluated before and after the one week of accelerated aging. The active oxygen levels of Example Composition A are shown in Table 2, below. The active oxygen levels in Table 2 were converted to weight percentages of peroxymonosulfate.Docket No. 950817-00- WO-Ol-OCTable 2Example 3

[0133] An in vitro enamel model was utilized to evaluate the whitening effect of Example Composition A relative to Comparative Composition 1 and a commercial product (Comparative Composition 2). Comparative Composition 2 contained at least the following listed ingredients: pumice, fluoride and xylitol.

[0134] Samples for each of Example Composition A, Comparative Composition 1, and Comparative Composition 2 of equivalent weights were applied to pre-brushed bovine enamel blocks. Prophylaxis was then performed with a rotary tool fitted with an airbrush followed by a robber cup for 2 min each in presence of 1 mL of water to simulate mixing with saliva and rinsed after each procedure.

[0135] The change in the color of the enamel blocks after the application of Example Composition A, Comparative Composition 1, or Comparative Composition 2 and prophylaxis was evaluated by determining the absolute values for AW and AYIO (optical yellowness index), where W (whiteness index) is determined by W = (a2+ b2+ (L-100)2)1 / 2and YIO (Optical Yellowness index) is determined by YIO = -Y -851.716(xn-x)-436.962(yn-y). Specifically, the AW and AYIO were derived from measurements of L, a, and b values using a spectrophotometer before and after prophylaxis. A larger change in AW and AYIO indicates a greater whitening effect. As seen in Table 3, Example Composition A delivered a significantly greater whitening effect than Comparative Compositions 1 or 2.Table 3Example 4

[0136] Three oral care compositions (Compositions 3-5) were prepared in the form of a toothpaste.The formulations for preparing Compositions 3-5 are shown in Table 4.Docket No. 950817-00- WO-Ol-OCTable 4

[0137] Compositions 3-5 were subjected to accelerated aging conditions to evaluate the stability of the peroxymonosulfate. Specifically, a sample was kept at a temperature of 60° C for 1 week. The active oxygen level was evaluated before and after the one week of accelerated aging. The active oxygen levels are shown in Table 5. The active oxygen levels in Table 5 were converted to weight percentages of peroxymonosulfate.Table 5

[0138] Additionally, three silicas were evaluated using Fourier transform infrared spectroscopy (FTIR) to determine their respective surface and bulk chemistry. The three silicas were: calcined amorphous silica abrasive (e.g., calcinated Zeodent™ 105); amorphous silica abrasive (noncalcinated) that was dried (e.g., dried Zeodent™ 105); and amorphous silica abrasive (noncalcinated) that was not dried by heating (e.g., Zeodent™ 105).

[0139] FIGURE is a graph of the Fourier transform infrared spectroscopy evaluating the relative presence and absence of silanol (Si-OH) groups and siloxane (-Si-O-Si-) groups in calcined amorphous silica abrasive, dried amorphous silica abrasive, and silica abrasive. Table 5 is the peek fit data and integrals of Si-0 and Si-OH.Docket No. 950817-00- WO-Ol-OCTable 5

[0140] The data in Table 5 was baseline corrected then normalized to the maxima. Peak fitting was performed using known vibrational modes of various types of bonding environments in silicas. Peak fitting analysis demonstrates absence of Si-O- / Si-OH in the calcined amorphous silica.

Claims

Docket No. 950817-00- WO-Ol-OCCLAIMSWhat is Claimed is:

1. An oral care composition comprising: a whitening agent comprising a peroxymonosulfate; one or more thickening agent; and from about 39 to about 73 wt.% of an abrasive, wherein all weight percentages are based on the total weight of the oral care composition.

2. The oral care composition according to claim 1, wherein the one or more thickening agent comprises a stearate and / or an acid thereof.

3. The oral care composition according to claim 2, wherein the stearate and / or the acid thereof comprises sodium stearate.

4. The oral care composition according to any foregoing claim, wherein the one or more thickening agent comprises a polyvinyl pyrrolidone, wherein the polyvinyl pyrrolidone has an average molecular weight in the range 5,000 to 100,000.

5. The oral care composition according to any foregoing claim, wherein the abrasive is present in an amount from about 42 to about 67 wt.%, optionally from about 45 to about 62 wt.%.

6. The oral care composition according to any foregoing claim, wherein the abrasive consists of silica abrasive(s) having surface that is free of Si-O_ / Si-OH bonds.

7. The oral care composition according to any foregoing claim, wherein the whitening agent consists of peroxymonosulfate.Docket No. 950817-00- WO-Ol-OC8. The oral care composition according to any foregoing claim, wherein the pcroxymonosulfatc comprises sodium pcroxymonosulfatc, potassium pcroxymonosulfatc, or a combination thereof.

9. The oral care composition according to any foregoing claim, wherein the amount of peroxymonosulfate is from about 0.5 to about 6 wt.%, optionally from about 0.75 to about 3 wt.%.

10. The oral care composition according to any foregoing claim, wherein the stearate and / or acid thereof comprises sodium stearate, potassium stearate, zinc stearate, ammonium stearate, stearic acid, or a combination of two or more thereof.

11. The oral care composition according to any foregoing claim, wherein the stearate and / or acid thereof is present in an amount from about 3 to about 15 wt.%, based on the total weight of the oral care composition.

12. The oral care composition according to any foregoing claim, wherein the oral care composition has a weight ratio of the peroxymonosulfate to the stearate and / or acid thereof of about 1.5:1 to about 1:4.

13. The oral care composition according to any foregoing claim, wherein the thickening agent further comprises about 0.1 to about 5 wt.% of silica thickener.

14. The oral care composition according to any foregoing claim further comprising: a solvent system comprising a polyoxypropylene-polyoxyethylene block copolymer, wherein the solvent system is present in an amount from about 5 to about 35 wt.%.

15. The oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of added water.Docket No. 950817-00- WO-Ol-OC16. The oral care composition according to any foregoing claim, wherein the abrasive is a calcinated amorphous silica abrasive.

17. The oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of polysaccharides and natural gums.

18. The oral care composition according to any foregoing claim, wherein the oral care composition is substantially free of or free of glycerin.

19. An oral care composition comprising: from about 0.1 to about 10 wt.%, based on the total weight of the oral care composition, of a whitening agent comprising a peroxymonosulfate; one or more thickening agent comprising sodium stearate and / or acid thereof; and from about 39 to about 73 wt.%, based on the total weight of the oral care composition, of one or more abrasive, wherein the one or more abrasive comprises a silica abrasive having a surface that is free of Si-O- / Si-OH bond, the silica abrasive having the surface that is free of Si- O- / Si-OH bond being about 91 wt.% or more of the total amount of abrasives, wherein the oral care composition is a dentifrice.

20. A method for reducing the color of an enamel substrate comprising: applying to any enamel substrate an oral care composition according to any foregoing claim.

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