Genetically modified yeast and fermentation processes for the production of xylitol
Genetically modified yeast cells with targeted enzyme modifications enhance xylitol production by reducing glycerol and erythritol yields, addressing inefficiencies in traditional xylitol production methods and offering a sustainable fermentation solution.
WO2026096423A1PCT designated stage Publication Date: 2026-05-07CARGILL INC
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- CARGILL INC
- Filing Date
- 2025-10-28
- Publication Date
- 2026-05-07
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Figure US2025052783_07052026_PF_FP_ABST
Abstract
Disclosed herein are genetically engineered yeast cells capable of producing xylitol and characterized by a deletion or disruption of a native gene encoding a glycerol-3-phosphate dehydrogenase 2a enzyme at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 98%, at least 99%, or 100% identical to SEQ ID NO:107. The genetically engineered yeast cell may additionally overexpress a native glycerol kinase enzyme, express a transketolase enzyme, have a deletion or disruption of a native gene encoding an erythrose reductase, be engineered to overexpress a native RPE enzyme, express an exogenous XPDH enzyme, express an exogenous XKS enzyme, express an exogenous XDH enzyme, overexpress a native X5PP enzyme, and / or express an exogenous X5PP enzyme.
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Citation Information
Patent Citations
Process for producing and recovering erythritol from culture medium containing the same
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Genetically modified yeast and fermentation processes for the production of xylitol
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Genetically modified yeast and fermentation processes for the production of xylitol
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