Mixtures containing ARYL amidines and biocontrol agents for fungal control

Abstract

Disclosed herein are fungicidal mixtures / compositions comprising an aryl amidine of formula I and at least one biocontrol agent. Also disclosed herein are methods of treating and controlling plant derived fungal pathogens or diseases, comprising contacting an area adjacent to the plant or soil adapted to support growth of the plant, or directly a seed, a root of the plant, and / or foliage of the plant, with a fungicidally effective amount of the fungicidal mixture or composition.

Description

MIXTURES CONTAINING ARYL AMIDINES AND BIOCONTROL AGENTS FOR FUNGAL CONTROLCROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Patent Application Serial No.63 / 718,611 filed November 9, 2024, which is expressly incorporated by reference herein.BACKGROUND

[0002] Fungicides are compounds of either natural or synthetic origin which act to treat or protect plants against damage caused by fungi and / or the ensuing disease. Currently the practice of agriculture relies on the use of fungicides. Using fungicides also allows a grower to increase the yield, quality of crop, and further increase the value of the crop.

[0003] However, no one fungicide is useful in all situations and repeated usage of a single fungicide frequently leads to the development of resistance for that particular pathogen and moreover, sometimes to other related fungicides. Further, among commercially available fungicides, biological control agents or biocontrol agents (BCAs) provide environmentally friendly and commercially attractive alternative to synthetic chemical pesticides. Accordingly, research is being conducted to produce new combinations of fungicides, especially with biocontrol agents, that are safer, have better performance, require lower dosages, are easier to use, and cost less.SUMMARY

[0004] The present disclosure provides mixtures and / or compositions thereof comprising the compound of Formula I:

[0005] The present disclosure also provides mixtures and / or compositions thereof comprising the compound of Formula I-B:

[0006] It is a further object of this disclosure to provide methods or processes that use these compositions. The mixtures and / or compositions thereof are capable of preventing or curing, or both, disease in crops.

[0007] In some aspects, the mixtures disclosed herein exhibit enhanced efficacy. “Enhanced efficacy” in the present disclosure refers to the simultaneous activity of two or more compounds resulting in a higher collective activity than the sum of the activities of the individual compounds.

[0008] Surprisingly, these mixtures and / or compositions may have enhanced efficacy against pathogens in crops. In accordance with this disclosure, mixtures and compositions are provided along with methods of their manufacture and methods for their use.

[0009] In one aspect, the present disclosure provides for a mixture of two active ingredients, wherein one of the active ingredients is the compound of Formula I. In one aspect, the present disclosure provides for a mixture of two active ingredients, wherein one of the active ingredients is the compound of Formula I-B. In one aspect, the present disclosure provides for a mixture of three active ingredients, wherein one of the active ingredients is the compound of Formula I. In one aspect, the present disclosure provides for a mixture of three active ingredients, wherein one of the active ingredients is the compound of Formula I-B. In one aspect, mixtures disclosed herein exhibit enhanced efficacy. Enhanced efficacy occurs when the activity of two or more active ingredients exceeds the sum of the activities of the active ingredients when used alone.

[0010] In one aspect of this disclosure provided are mixtures including the compound of Formula I and at least one biocontrol agent.DETAILED DESCRIPTION

[0011] Definitions

[0012] Various terms used in the specification and claims herein are defined as set forth below, unless otherwise specifically defined in this disclosure. All technical and scientific terms not defined herein have the meaning commonly understood by a person skilled in the art to which this disclosure belongs.

[0013] "Phytologically acceptable amount" refers to an amount of a compound that kills or inhibits the plant disease for which control is desired but is not significantly toxic to the plant. This amount will generally be from about 0.1 to about 1000 ppm (parts per million), with 1 to 500 ppm being preferred. The exact concentration of compound required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like. A suitable application rate is typically in the range from about 0.10 to about 4 pounds / acre (about 0.01 to 0.45 grams per square meter, g / m2).

[0014] As used herein, the term "salt" refers to salts which are suitable for use in agriculture, i.e. they affect humans and lower animals without undue toxicity, irritation, allergic response and the like, and are commensurate with a reasonable benefit / risk ratio in agriculture. These salts are well known in the art. Salts of the compounds described herein include those derived from suitable inorganic and organic acids and bases. Examples of acid addition salts are salts of an amino group formed with inorganic acids such as hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid and perchloric acid or with organic acids such as acetic acid, oxalic acid, maleic acid, tartaric acid, citric acid, succinic acid or malonic acid or by using other methods used in the art such as ion exchange. Other salts include, but are not limited to, adipate, alginate, ascorbate, aspartate, benzenesulfonate, benzoate, bisulfate, borate, butyrate, camphorate, camphorsulfonate, citrate, cyclopentanepropionate, digluconate, dodecyl sulfate, ethanesulfonate, formate, fumarate, glucoheptonate, glycerophosphate, gluconate, hemi sulfate, heptanoate, hexanoate, hydroiodide, 2-hydroxy-ethanesulfonate, lactobionate, lactate, laurate, lauryl sulfate, malate, maleate, malonate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, nitrate, oleate, oxalate, palmitate, pamoate, pectinate, persulfate, 3-phenylpropionate, phosphate,pivalate, propionate, stearate, succinate, sulfate, tartrate, thiocyanate, / ?-toluenesulfonate, undecanoate, valerate salts, and the like. Salts derived from appropriate bases include alkali metal, alkaline earth metal, ammonium salts. Representative alkali or alkaline earth metal salts include sodium, lithium, potassium, calcium, magnesium, and the like. Further agriculturally acceptable salts include, when appropriate, nontoxic ammonium, quaternary ammonium, and amine cations formed using counterions such as halide, hydroxide, carboxylate, sulfate, phosphate, nitrate, lower alkyl sulfonate and aryl sulfonate.

[0015] Additional Interpretational Conventions

[0016] The compounds described herein may exist as solvates, especially hydrates, and unless otherwise specified, all such solvates and hydrates are intended. Hydrates may form during manufacture of the compounds or compositions comprising the compounds, or hydrates may form over time due to the hygroscopic nature of the compounds. Compounds of the present technology may exist as organic solvates as well, including N, .V-dimethylformamide (DMF), ether, and alcohol solvates, among others. The identification and preparation of any particular solvate is within the skill of the ordinary artisan of synthetic organic or medicinal chemistry and are readily attainable using the textbook and other general synthetic references disclosed herein.

[0017] Throughout this application, the text refers to various aspects of the present compounds, compositions, and methods. The various aspects described are meant to provide a variety of illustrative examples and should not be construed as descriptions of alternative species. Rather, it should be noted that the descriptions of various aspects provided herein may be of overlapping scope. The aspects discussed herein are merely illustrative and are not meant to limit the scope of the present technology.

[0018] For the purposes of this specification and appended claims, unless otherwise indicated, all numbers expressing amounts, sizes, dimensions, proportions, shapes, formulations, parameters, percentages, parameters, quantities, characteristics, and other numerical values used in the specification and claims, are to be understood as being modified in all instances by the term “about” even though the term “about” may not expressly appear with the value, amount or range. Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are not and need not be exact, but may beapproximate and / or larger or smaller as desired, reflecting tolerances, conversion factors, rounding off, measurement error and the like, and other factors known to those of skill in the art depending on the desired properties sought to be obtained by the presently disclosed subject matter. For example, the term “about,” when referring to a value can be meant to encompass variations of, in some aspects ± 100%, in some aspects ± 50%, in some aspects ± 20%, in some aspects ± 10%, in some aspects ± 5%, in some aspects ±1%, in some aspects ± 0.5%, and in some aspects ± 0.1% from the specified amount, as such variations are appropriate to perform the disclosed methods or employ the disclosed compositions.

[0019] As used herein and in the appended claims, singular articles such as “a,” “an” and “the” and similar referents in the context of describing the elements (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The use of the term “at least one” followed by a list of one or more items (for example, “at least one of A and B”) is to be construed to mean one item selected from the listed items (A or B) or any combination of two or more of the listed items (A and B), unless otherwise indicated herein or clearly contradicted by context. The terms “comprising,” “having,” “including,” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, including the upper and lower bounds of the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it are individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate the aspects and does not pose a limitation on the scope of the claims unless otherwise stated. No language in the specification should be construed as indicating any non-claimed element as essential.

[0020] Mixtures and Components

[0021] The present disclosure provides mixtures and / or compositions thereof comprising the compound of Formula I:

[0022] The present disclosure also provides mixtures and / or compositions thereof comprising the compound of Formula I-B:

[0023] In one aspect, the compound of Formula 1 is 4-(difluoromethoxy)benzyl 4- (((ethyl(methyl)amino)methylene)amino)-2,5-dimethylbenzoate, or an agriculturally acceptable salt, solvate, or hydrate thereof.

[0024] In one aspect, the compound of Formula I-B is 4-(difluoromethoxy)benzyl 4- (((ethyl(methyl)amino)methylene)amino)-2,5-dimethylbenzoate hydrochloride, or a solvate, or hydrate thereof.

[0025] Throughout the disclosure, reference to the compounds of Formula I and Formula I-B is read as also including all regioisomers, structural isomers, geometrical isomers, rotational isomers, tautomers, and stereoisomers, for example diastereomers, enantiomers, and mixtures thereof.

[0026] The compounds of Formula I and Formula I-B may also contain linkages (e g., carbon-carbon bonds) wherein bond rotation is restricted about that particular linkage e.g., restriction resulting from the presence of a ring or a double bond. Accordingly, any cis / trans and E / Z isomers are expressly included in the present disclosure.

[0027] The compounds of Formula I and Formula I-B may also be present in multiple tautomeric forms. Where one or more tautomeric forms exist, the disclosure expresslyincludes all such tautomeric forms of the compounds described herein, even though only a single tautomeric form may be represented.

[0028] The compounds of Formula I and Formula I-B may exist in one or more crystalline or polymorphic forms. All crystalline forms and polymorphs of the compounds of the disclosure are expressly included in the present disclosure.

[0029] The structures of Formula I and Formula I-B, as well as their syntheses and fungicidal applications via agricultural formulation or composition, are disclosed in patent application No.PCT / US2024 / 027678, which is herein incorporated in its entirety. The compounds of Formula I and Formula I-B display some fungicidal activity in the reference above.

[0030] In one aspect, the disclosure provides for a mixture comprising a compound of Formula I:and at least one biocontrol agent.

[0031] In one aspect, the mixtures disclosed herein exhibit enhanced efficacy.

[0032] In one aspect, the disclosure provides for a mixture comprising a compound ofFormula I and one biocontrol agent.

[0033] In one aspect, the disclosure provides for a mixture comprising a compound of Formula I and two biocontrol agents.

[0034] In one aspect, the disclosure provides for a mixture comprising a compound of Formula I-B:and at least one biocontrol agent.

[0035] In one aspect, the disclosure provides for a mixture comprising a compound of Formula I-B and one biocontrol agent.

[0036] In one aspect, the disclosure provides for a mixture comprising a compound of Formula I-B and two biocontrol agents.

[0037] A biocontrol agent may be any living organism applied to or introduced into the environment that is intended to function as a pesticide against a pest. A biocontrol agent may be a micro-organism, a macro-organism, a semiochemical, a plant growth regulator, or a botanical.

[0038] A biocontrol agent may function as an herbicide, an insecticide, a fungicide, a nematicide, a miticide, an arthropodicide, a bactericide, a plant growth regulator, or combinations thereof. The biocontrol agent disclosed herein may include, but not limited to, direct acting microbials, biochemical elicitors, and plant immunity inducers (for example, the ones that trigger Systemic Acquired Resistance (SAR)).

[0039] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one fungicidal biocontrol agent.

[0040] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one fungicidal biocontrol agent.

[0041] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one botanical biocontrol agent selected from Laminarin (i.e., from Arysta LifeScience under tradename “Vacciplant”), Thymol (i.e., from Key Industries Ltd under tradename “Thymovar”), Geraniol (i.e., from Eden Research PLC under tradename “Mevalone”), Eugenol (i.e., from Eden Research PLC under tradename “Mevalone”), Neem oil (i.e., from Certis USA under tradename “Trilogy”), Reynoutria sachalinensis extract (i.e., from Marrone Bio Innovations under tradename “Regalia”), Soya bean oil (i.e., from Botry-Zen (2010) Limited under tradename “MIDI-Zen”), Tea tree oil (i.e., from Stockton Group under tradename “Timorex Gold”), Fennel oil (i.e., from Andermatt Biocontrol AG under tradename “Fenicur”), and mixtures thereof. Preferred botanical biocontrol agents are Laminarin and Reynoutria sachalinensis extract.

[0042] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one botanical biocontrol agent selected from Laminarin (i.e., fromArysta LifeScience under tradename “Vacciplant”), Thymol (i.e., from Key Industries Ltd under tradename “Thymovar”), Geraniol (i.e., from Eden Research PLC under tradename “Mevalone”), Eugenol (i.e., from Eden Research PLC under tradename “Mevalone”), Neem oil (i.e., from Certis USA under tradename “Trilogy”), Reynoutria sachalinensis extract (i.e., from Marrone Bio Innovations under tradename “Regalia”), Soya bean oil (i.e., from Botry-Zen (2010) Limited under tradename “MIDI-Zen”), Tea tree oil (i.e., from Stockton Group under tradename “Timorex Gold”), Fennel oil (i.e., from Andermatt Biocontrol AG under tradename “Fenicur”), and mixtures thereof. Preferred botanical biocontrol agents are Laminarin and Reynoutria sachalinensis extract.

[0043] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Laminarin.

[0044] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Reynoutria sachalinensis extract.

[0045] In one aspect, the disclosure provides for a mixture containing a compound of Formula LB and Laminarin.

[0046] In one aspect, the disclosure provides for a mixture containing a compound of Formula LB and Reynoutria sachalinensis extract.

[0047] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from yeast-derived materials. Yeast-derived materials suitable for fungicidal purposes include, but are not limited to, whole cell wall extracts of Saccharomyces cerevisiae. Preferably, yeast-derived materials suitable for fungicidal purposes is the cell walls of Saccharomyces cerevisiae strain LAS117 (i.e., from Agrauxine under this tradename “Romeo”).

[0048] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and the cell walls of Saccharomyces cerevisiae strain LAS117.

[0049] In one aspect, the disclosure provides for a mixture containing a compound of Formula LB and the cell walls of Saccharomyces cerevisiae strain LAS117.

[0050] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one plant immunity inducer selected from plant immunity inducers thattrigger Systemic Acquired Resistance (SAR). Preferred from plant immunity inducers that trigger Systemic Acquired Resistance (SAR) include, but are not limited to, Acibenzolar-S- methyl (Acibenzolar-S-methyl is the common name for ,S'-m ethyl benzo[l,2,3]thiadiazole-7- carbothioate. i.e., from Syngenta under the tradename “Actigard”), the cell walls of Saccharomyces cerevisiae strain LAS117 (i.e., from Agrauxine under this tradename “Romeo”), Laminarin (i.e., from Arysta LifeScience under tradename “Vacciplanf ’). More preferred plant immunity inducers are the cell walls of Saccharomyces cerevisiae strain LAS117 and Laminarin.

[0051] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Acibenzolar-S-methyl.

[0052] In one aspect, the disclosure provides for a mixture containing a compound of Formula LB and Acibenzolar-S-methyl.

[0053] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one plant grown regulator such as organic acid, or ester, salt, or derivative thereof. Preferably, the mixture of the present disclosure comprises a compound of Formula I and at least one organic acid, or ester or salt thereof. The organic acid, or acceptable ester, salt, or derivative thereof may be selected from the groups consisting of acetic acid, lactic acid, citric acid, malic acid, formic acid, propionic acid, butyric acid, oxalic acid, succinic acid, tartaric acid, benzoic acid, ascorbic acid, salicylic acid, jasmonic acid, indole-3 -acetic acid, abscisic acid, chlorogenic acid, ferulic acid, rosmarinic acid, and esters, salts, and derivatives thereof. In some preferred aspects, the organic acid, or ester, salt, or derivative thereof is selected from salicylic acid, esters of salicylic acid, and salts of salicylic acid. In one preferred aspect, the ester of salicylic acid is methyl salicylate.

[0054] In some preferred aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one organic acid selected from the groups consisting of acetic acid, lactic acid, citric acid, malic acid, formic acid, propionic acid, butyric acid, oxalic acid, succinic acid, tartaric acid, benzoic acid, ascorbic acid, salicylic acid, jasmonic acid, indole- 3-acetic acid, abscisic acid, chlorogenic acid, ferulic acid, and rosmarinic acid. Preferred organic acid is salicylic acid.

[0055] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and salicylic acid.

[0056] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and salicylic acid.

[0057] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and methyl salicylate.

[0058] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and methyl salicylate.

[0059] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one microbial biocontrol agent selected from fungi, bacteria, virus, and mixtures thereof.

[0060] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one microbial biocontrol agent selected from fungi, bacteria, virus, and mixtures thereof.

[0061] Bacteria suitable for fungicidal purposes include, but are not limited to, Bacillus bacteria and Pseudomonas' aci na.

[0062] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus bacteria, Pseudomonas bacteria, and mixtures thereof.

[0063] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Bacillus bacteria, Pseudomonas bacteria, and mixtures thereof.

[0064] Bacillus bacteria may include, but are not limited to, Bacillus acidiceler, Bacillus acidicola, Bacillus acidiproducens, Bacillus aeolius, Bacillus aerius, Bacillus aerophilus, Bacillus agaradhaerens, Bacillus aidingensis, Bacillus akibai, Bacillus alcalophilus, Bacillus algicola, Bacillus alkalinitrilicus, Bacillus alkalisediminis, Bacillus alkalitellur is, Bacillus altitudinis, Bacillus alveayuensis, Bacillus amyloliquefaciens, Bacillus anthracis, Bacillus aquimaris, Bacillus arsenicus, Bacillus aryabhattai, Bacillus asahii, Bacillus atrophaeus, Bacillus aurantiacus, Bacillus azotoformans, Bacillus badius, Bacillus barbaricus, Bacillusbataviensis, Bacillus beijingensis, Bacillus benzoevorans, Bacillus beveridgei, Bacillus bogoriensis, Bacillus boroniphilus, Bacillus butanolivorans, Bacillus canaveralius, Bacillus carboniphilus, Bacillus cecembensis, Bacillus cellulosilyticus, Bacillus cereus, Bacillus chagannorensis, Bacillus chungangensis, Bacillus cibi, Bacillus circulans, Bacillus clarkii, Bacillus clausii, Bacillus coagulans, Bacillus coahuilensis, Bacillus cohnii, Bacillus decisifrondis, Bacillus decolorationis, Bacillus drentensis, Bacillus farraginis, Bacillus fastidiosus, Bacillus firmus, Bacillus flexus, Bacillus foraminis, Bacillus fordii, Bacillus foris, Bacillus fumarioli, Bacillus funiculus, Bacillus galactosidilyticus, Bacillus galliciensis, Bacillus gelatini, Bacillus gibsonii, Bacillus ginsengi, Bacillus ginsengihumi, Bacillus graminis, Bacillus halmapalus, Bacillus halochares, Bacillus halodurans, Bacillus hemicellulosilyticus, Bacillus herbertsteinensis, Bacillus horikoshi, Bacillus horneckiae, Bacillus horti, Bacillus humi, Bacillus hwajinpoensis, Bacillus idriensis, Bacillus indicus, Bacillus infantis, Bacillus infernus, Bacillus isabeliae, Bacillus isronensis, Bacillus jeotgali, Bacillus koreensis, Bacillus korlensis, Bacillus kribbensis, Bacillus krulwichiae, Bacillus lehensis, Bacillus lentus, Bacillus licheniformis, Bacillus litoralis, Bacillus locisalis, Bacillus luciferensis, Bacillus luteolus, Bacillus macauensis, Bacillus macyae, Bacillus mannanilyticus, Bacillus mariflavi, Bacillus marmarensis, Bacillus massiliensis, Bacillus megaterium, Bacillus methanolicus, Bacillus methylotrophicus, Bacillus mojavensis, Bacillus muralis, Bacillus murimartini, Bacillus mycoides, Bacillus nanhaiensvis, Bacillus nanhaiisediminis, Bacillus nealsonii, Bacillus neizhouensis, Bacillus niabensis, Bacillus niacini, Bacillus novalis, Bacillus oceanisediminis, Bacillus odysseyi, Bacillus okhensis, Bacillus okuhidensis, Bacillus oleronius, Bacillus oshimensis, Bacillus panaciterrae, Bacillus patagoniensis, Bacillus persepolensis, Bacillus plakortidis, Bacillus pocheonensis, Bacillus polygoni, Bacillus pseudoalcaliphilus, Bacillus pseudofirmus, Bacillus pseudomycoides, Bacillus psychrosaccharolyticus, Bacillus pumilus, Bacillus qingdaonensis, Bacillus rigui, Bacillus ruris, Bacillus safensis, Bacillus salarius, Bacillus saliphilus, Bacillus schlegelii, Bacillus selenatarsenatis, Bacillus selenitireducens, Bacillus seohaeanensis, Bacillus shackletonii, Bacillus siamensis, Bacillus simplex, Bacillus siralis, Bacillus smithii, Bacillus soli, Bacillus solisalsi, Bacillus sonorensis, Bacillus sporothermodurans, Bacillus stratosphericus, Bacillus subterraneus, Bacillus subtilis, Bacillus taeansis, Bacillus tequilensis, Bacillus thermantarcticus,Bacillus thermoamylovorans, Bacillus thermocloacae, Bacillus thermolactis, Bacillus thioparans, Bacillus thuringiensis, Bacillus tripoxylicola, Bacillus tusciae, Bacillus vallismortis, Bacillus vedderi, Bacillus vietnamensis, Bacillus vireti, Bacillus wakoensis, Bacillus weihenstephanensis, Bacillus xiaoxiensis, and mixtures or blends thereof.

[0065] Preferred Bacillus species include, but are not limited to, Bacillus amyloliquefaciens, Bacillus subtil is. Bacillus velezensis, Bacillus mycoides, and Bacillus pumilus.

[0066] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens Bacillus subtilis, Bacillus velezensis, Bacillus mycoides, Bacillus pumilus, and mixtures or blends thereof.

[0067] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and a biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens, Bacillus subtilis, Bacillus pumilus, and mixtures or blends thereof.

[0068] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and Bacillus amyloliquefaciens.

[0069] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and Bacillus subtilis.

[0070] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and Bacillus pumilus.

[0071] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens, Bacillus subtilis, Bacillus pumilus, and mixtures or blends thereof.

[0072] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and a biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens, Bacillus subtilis, Bacillus pumilus, and mixtures or blends thereof.

[0073] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and Bacillus amyloliquefaciens.

[0074] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and Bacillus subtilis.

[0075] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and Bacillus pumilus.

[0076] Pseudomonas bacteria may include, but are not limited to, Pseudomonas protegens, Pseudomonas saponiphila, Pseudomonas ficuserectae, Pseudomonas congelans, Pseu domonas tremae, Pseudomonas caricapapayae, Pseudomonas mandelii, Pseudomonas savastano i, Pseudomonas syringae, Pseudomonas chlororaphis subsp. piscium, Pseudomonas cannabina, Pseudomonas marginalis, Pseudomonas simiae, Pseudomonas avellanae, Pseudomonas chloror aphis subsp. aurantiaca, Pseudomonas chlororaphis subsp. chlororaphis, Pseudomonas frederik sbergensis, Pseudomonas amygdali, Pseudomonas extremaustralis, Pseudomonas kilonensis, Ps eudomonas lini, Pseudomonas Antarctica, Pseudomonas corrugata, Pseudomonas poae, Pseudo monas grimontii, Pseudomonas brassicacearum subsp. Neoaurantiaca, Pseudomonas meridian, Pseudomonas trivialis, Pseudomonas veronii, Pseudomonas lundensis, Pseudomonas salomonii, Pseudomonas rhodesiae, Pseudomonas arsenicoxydans, Pseudomonas thivervalensis, Pseudomo nas deceptionensis, Pseudomonas palleroniana, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas costantinii, Pseudomonas lurida, Pseudomonas migulae, Pseudomonas orientalis, Pseudomonas extremorientalis, Pseudomonas mediterranea, Pseudomonas brassicacearum sub sp. brassicacearum, Pseudomonas abietaniphila, Pseudomonas baetica, Pseudomonas brenneri, Pseudomonas psychrophila, Pseudomonas jessenii, Pseudomonas fragi, Pseudomonas tolaasii, P seudomonas proteolytica, Pseudomonas taetrolens, Pseudomonas mohnii, Pseudomonas moorei, Pseudomonas moraviensis, Pseudomonas gessardii, Pseudomonas cichorii, Pseudomonas liban ensis, Pseudomonas benzenivorans, Pseudomonas panacis, Pseudomonas umsongensis, Pseudo monas reinekei, Pseudomonas fluorescens, Pseudomonas agarici, Pseudomonas lutea, Pseudom onas mucidolens, Pseudomonas azotoformans, Pseudomonas viridiflava, Pseudomonas koreensis , Pseudomonas kuykendallii, Pseudomonas synxantha, Pseudomonas segetis, Pseudomonas mari ncola, Pseudomonas cedrina subsp. cedrina, Pseudomonas graminis, Pseudomonas vancouveren sis, Pseudomonas cedrina subsp . fulgida, Pseudomonas plecoglossicida, Pseudomonas cuatrocie negasensis, Pseudomonas taiwanensis, Pseudomonas putida Pseudomonas rhizosphaerae, Pseud omonas anguilliseptica, Pseudomonas monteilii, Pseudomonas fuscovaginae, Pseudomonas mos selii, Pseudomonas taeanensis, Pseudomonas asplenii, Pseudomonas entomophila, Pseudomona5 cremoricolorata, Pseudomonas parafulva, Pseudomonas alcaliphila, Pseudomonas oleovorans subsp. lubricantis, Pseudomonas borbori, Pseudomonas composti, Pseudomonas toyotomiensis, Pseudomonas batumici, Pseudomonas flavescens, Pseudomonas vranovensis, Pseudomonas pun onensis, Pseudomonas balearica, Pseudomonas indoloxydans, Pseudomonas guineae, Pseudomo nas japonica Pseudomonas stutzeri, Pseudomonas seleniipraecipitans, Pseudomonas peli, Pseud omonas fulva, Pseudomonas argentinensis, Pseudomonas xanthomarina, Pseudomonas pohange nsis, Pseudomonas oleovorans, Pseudomonas mendocina, Pseudomonas luteola, Pseudomonas s traminea, Pseudomonas caeni, Pseudomonas aeruginosa, Pseudomonas tuomuerensis, Pseudom onas azotgens, Pseudomonas indica, Pseudomonas oryzihabitans, Pseudomonas otitidis, Pseudo monas psychrotolerans, Pseudomonas zeshuii, Pseudomonas resinovorans, Pseudomonas oleovo rans subsp. oleovorans, Pseudomonas thermotolerans, Pseudomonas bauzanensis, Pseudomonas duriflava, Pseudomonas pachastr ellae, Pseudomonas citronellolis, Pseudomonas alcaligenes, P seudomonas xinjiangensis, Pseudomonas delhiensis, Pseudomonas sabulinigri, Pseudomonas lit oralis, Pseudomonas pelagia, Pseudomonas linyingensis, Pseudomonas knackmussii, Pseudomo nas panipatensis, Pseudomonas nitroreducens, Pseudomonas nitritireducens, Pseudomonas jinju ensis, Pseudomonas pertucinogena, Pseudomonas xiamenensis, Pseudomonas cissicola, Pseudo monas halophile, Pseudomonas boreopolis, Pseudomonas geniculate, Pseudomonas beteli, Pseu domonas hibiscicola, Pseudomonas pictorum, Pseudomonas carboxydohydrogena, and mixtures or blends therefore.

[0077] Preferred Pseudomonas species include, but not limited to, Pseudomonas putida, Pseudomonas syringae, Pseudomonas aeruginosa, Pseudomonas Fluorescens, and Pseudomonas chlororaphis.

[0078] The microbial biological agents disclosed herein may be commercially available or may be obtained by culturing. For example, the Bacillus strains disclosed herein can be obtained by culturing Bacillus amyloliquifaciens strain, or a fungicidal mutant strain derived therefrom using well-known methods of art. Conventional large scale culture processes such as submerged fermentation, solid state fermentation, or liquid surface culture can be used to obtain the biological agents disclosed herein. The bacterial cells, spores and metabolites in culture media resulting from the fermentation may be used directly or concentrated by conventional methodssuch as centrifugation, tangential -flow filtration, depth filtration and evaporation. The term "fermentation" refers broadly to the enzymatic and anaerobic or aerobic breakdown of organic substances (e.g., a carbon substrate) by microorganisms under controlled conditions (e.g., temperature, oxygen, pH, nutrients, and the like) to produce fermentation products. While fermentation typically describes processes that occur under anaerobic conditions, as used herein it is not intended that the term be solely limited to strict anaerobic conditions, as the term "fermentation" used herein may also occur processes that occur in the presence of oxygen.

[0079] Cell-free preparations of fermentation broth of the strains disclosed herein can be obtained by any means known in the art, such as extraction, centrifugation and / or filtration of fermentation broth. Those of skill in the art will appreciate that so-called cell-free preparations may not be devoid of cells but rather are largely cell-free or essentially cell-free, depending on the technique used (e.g., speed of centrifugation) to remove the cells. The resulting cell-free preparation may be dried and / or formulated with components that aid in its application to plants or to plant growth media. Concentration methods and drying techniques known in the skill of art for fermentation broth are also applicable to cell-free preparations.

[0080] In some aspects, the microbial biocontrol agent may comprise lipopeptide, Microbe- Associated Microbial Pattern (MAMP), bacteriocin, siderophore, lytic enzyme, polyketide, and mixtures thereof. Lipopeptides might be linear or cyclic. Suitable examples of cyclic lipopeptides include, but are not limited to, Surfactin, Iturin, Fengycin, Kurstakins, and Bacillibactin.Bacteriocins maybe be post-translationally modified (class I - Lantibiotics) or non-modified (class II). Suitable examples of Bacteriocins include, but are not limited to, Subtilin, Ericins, Mersacidin, Amylolysin, Sublancin, Paenibacillin, Haloduracin, Lichenicidin, Subtulosin, Thuricidin, Pseudomycoicidin, Coagulin, various SRCAMs, various Thuricins and Thuricin- likes, Cereins, Lichenin, Bacillocyn, Bacicyclin, N3 lipopeptide, SAMP, BaCfB, Amylocyclin, BAM P, Sonorensin, Megacins, Sublancin, and Glycocin G. Suitable examples of lytic enzymes include, but are not limited to, chitinases, glucanases, cellulases, proteases, and lipases. Suitable examples of polyketides includes, but are not limited to, bacillaene, difficidin, and macrolactin.

[0081] In some aspects, the microbial biocontrol agent comprises at least about IxlO4colony forming units (CFU) of the microorganism / gram of the respective active component. In one aspect, the biocontrol agent comprises at least about IxlO5CFU of the microorganism / gram of the respective active component. In another aspect, the biocontrol agent comprises at least about IxlO6CFU of the microorganism / gram of the respective active component. In another aspect, the biocontrol agent comprises at least about IxlO7CFU of the microorganism / gram of the respective active component. In another aspect, the biocontrol agent comprises at least about IxlO8CFU of the microorganism / gram of the respective active component. In another aspect, the biocontrol agent comprises at least about IxlO9CFU of the microorganism / gram of the respective active component. In another aspect, the biocontrol agent comprises at least about IxlO10CFU of the microorganism / gram of the respective active component. In another aspect, the biocontrol agent comprises at least about IxlO1 1CFU of the microorganism / gram of the respective active component.

[0082] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Pseudomonas putida, Pseudomonas syringae, Pseudomonas aeruginosa Pseudomonas Fluorescens, Pseudomonas chlororaphis. and mixtures or blends thereof.

[0083] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and a biocontrol agent selected from the group consisting of Bacillus Pseudomonas putida, Pseudomonas chlororaphis, and mixtures or blends thereof.

[0084] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and Pseudomonas putida.

[0085] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and Pseudomonas chlororaphis.

[0086] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Pseudomonas putida, Pseudomonas chlororaphis, and mixtures or blends thereof.

[0087] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and a biocontrol agent selected from the group consisting of Bacillus Pseudomonas puli da. Pseudomonas chlororaphis, and mixtures or blends thereof.

[0088] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and Pseudomonas putida.

[0089] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and Pseudomonas chlororaphis .

[0090] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens, Bacillus subtilis, Bacillus pumilus, Pseudomonas putida, Pseudomonas chlororaphis, and mixtures or blends thereof.

[0091] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens, Bacillus subtilis, Bacillus pumilus, Pseudomonas putida, Pseudomonas chlororaphis, and mixtures or blends thereof.

[0092] Preferred strains of Bacillus bacteria include, but are not limited to, Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Bacillus amyloliquefaciens MB 1600, Bacillus amyloliquefaciens FZB24, Bacillus amyloliquefaciens PTA-4838, Bacillus subtilis QST713, Bacillus subtilis FZB24, Bacillus subtilis BV02, and Bacillus pumilus QST2808. More preferred strains of Bacillus bacteria are Bacillus amyloliquefaciens QST713 and Bacillus amyloliquefaciens D747.

[0093] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Bacillus amyloliquefaciens MB 1600, Bacillus amyloliquefaciens FZB24, Bacillus amyloliquefaciens PTA-4838, Bacillus subtilis BV02, Bacillus pumilus QST2808, and mixtures or blends thereof.

[0094] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Bacillus amyloliquefaciensMB 1600, Bacillus amyloliquefaciens FZB24, Bacillus amyloliquefaciens PTA-4838, Bacillus subtilis BV02, Bacillus pumilus QST2808, and mixtures or blends thereof.

[0095] Preferred strains of Pseudomonas bacteria include, but are not limited to, Pseudomonas putida B2017 and Pseudomonas chlororaphis AFS009. More preferred strain of Pseudomonas bacteria is Pseudomonas chlororaphis AFS009.

[0096] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Pseudomonas putida B2017, Pseudomonas chlororaphis AFS009, and mixtures or blends thereof.

[0097] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Pseudomonas putida B2017, Pseudomonas chlororaphis AFS009, and mixtures or blends thereof.

[0098] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Bacillus amyloliquefaciens MBI600, Bacillus amyloliquefaciens FZB24, Bacillus amyloliquefaciens PTA-4838, Bacillus subtilis BV02, Bacillus pumilus QST2808, P seudomonas putida B2017, Pseudomonas chlororaphis AFS009, and mixtures or blends thereof.

[0099] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Bacillus amyloliquefaciens MBI600, Bacillus amyloliquefaciens FZB24, Bacillus amyloliquefaciens PTA-4838, Bacillus subtilis BV02, Bacillus pumilus QST2808, P seudomonas putida B2017, Pseudomonas chlororaphis AFS009, and mixtures or blends thereof.

[0100] Bacillus subtilis QST713 (also known as Bacillus amyloliquefaciens QST713) has the mode of action of nutrient competition, site exclusion, colonization and attachment of the bacteria to the fungal or bacterial pathogen induce systemic resistant response in plants.Commercial products containing Bacillus subtilis QST713 can be purchased from Bayer under the trade name of Serenade.

[0101] Bacillus amyloliquefaciens D747 has the mode of action of pathogenic to plant pathogenic organisms on foliage and other plant parts by producing antibiotic compounds (iturins) that disrupt pathogen cell wall production. Commercial products containing Bacillus amyloliquefaciens D747 can be purchased from Certis USA under the trade name Double Nickel.

[0102] Bacillus amyloliquefaciens MBI 600 (also known as Bacillus subtilis MBI 600) has the model of action of colonizing the developing root system of young plants and competing with and thereby suppressing pathogens that attack root systems. Commercial products containing Bacillus amyloliquefaciens MBI 600 can be purchased from BASF under trade name Serifel.

[0103] Bacillus subtilis subsp. amyloliquefaciens FZB24 (also known Bacillus subtilis FZB24 or Bacillus amyloliquefaciens FZB24) has the mode of action of colonizing plant roots and stimulating the plant's defense system to various soil pathogens. Commercial products containing Bacillus subtilis subsp. amyloliquefaciens FZB24 can be purchased from Novozymes under the trade name Taegro.

[0104] Bacillus pumilus QST 2808 has the mode of action of forming a physical barrier between the spores and the leaf surface thereby preventing the germination of fungal spores on plants. Commercial products containing Bacillus pumilus QST 2808 can be purchased from Bayer under the trade name Sonata.

[0105] The fungicidal activity for the above-mentioned fungicidal biocontrol agent is described in Manual of Biocontrol Agents, by the British Crop Production Council. Each one of these biocontrol agents can be obtained commercially through vendors such as BASF, Bayer, and the like.

[0106] Bacillus amyloliquefaciens PTA-4838 can be used to suppress fungi and promote plant growth by foliar application as well as applications made in residential settings. Commercial fungicidal products containing Bacillus amyloliquefaciens PTA-4838 can be purchased from Sumitomo and VBC under the trade names Lumialza, Aveo, and Zorda.

[0107] Commercial fungicidal products containing Pseudomonas putida B2017 can be purchased from Futureco.

[0108] Commercial fungicidal products containing Pseudomonas chlororaphis AFS009 can be purchased from Certis under the trade name Howler.

[0109] In one aspect, the disclosure provides for a mixture comprising a compound of Formula I and at least one biocontrol agent. In one aspect, the disclosure provides for a mixture comprising a compound of Formula I-B and at least one biocontrol agent.

[0110] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus amyloliquefaciens QST713.[OHl] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus amyloliquefaciens D747.

[0112] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus amyloliquefaciens MBI600.

[0113] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus amyloliquefaciens FZB24.

[0114] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus amyloliquefaciens PTA-4838.

[0115] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus subtilis BV02.

[0116] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Bacillus pumilus QST2808.

[0117] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and Pseudomonas putida B2017.

[0118] In one aspect, the disclosure provides for a mixture containing a compound of Formula I and which is Pseudomonas chlororaphis AFS009.

[0119] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus amyloliquefaciens QST713.

[0120] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus amyloliquefaciens D747.

[0121] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus amyloliquefaciens MBI600.

[0122] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus amyloliquefaciens FZB24.

[0123] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus amyloliquefaciens PTA-4838.

[0124] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus subtilis BV02.

[0125] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Bacillus pumilus QST2808.

[0126] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and Pseudomonas putida B2017.

[0127] In one aspect, the disclosure provides for a mixture containing a compound of Formula I-B and which is Pseudomonas chlororaphis AFS009.

[0128] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Pseudomonas chlororaphis AFS009, the cell walls of Saccharomyces cerevisiae strain LAS117, Laminarin, Reynoutria sachalinensis extract, Acibenzolar-S-methyl, and mixtures or blends thereof.

[0129] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of BacillusAFS009, the cell walls of Saccharomyces cerevisiae strain LAS117, Laminarin, Reynoutria sachalinensis extract, salicylic acid, methyl salicylate, and mixtures or blends thereof.

[0130] In some aspects, the mixture of the present disclosure comprises a compound of Formula I and at least one biocontrol agent selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens Yl f Pseudomonas chlororaphis AFS009, the cell walls of Saccharomyces cerevisiae strain LAS 117, Laminarin, Reynoutria sachalinensis extract, and mixtures or blends thereof.

[0131] In some aspects, the mixture of the present disclosure comprises a compound of Formula I-B and at least one biocontrol agent selected from the group consisting of Bacillusamyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Pseudomonas chlororaphis AFS009, the cell walls of Saccharomyces cerevisiae strain LAS 117, Laminarin, Reynoutria sachalinensis extract, and mixtures or blends thereof.

[0132] Ranges / Concentrations

[0133] In one aspect, the mixtures disclosed herein are present at a weight ratio of a compound of Formula I to a biocontrol agent that exhibits enhanced efficacy.

[0134] In one aspect, the mixtures disclosed herein are present at a weight ratio of a compound of Formula LB to a biocontrol agent that exhibits enhanced efficacy.

[0135] In various aspects, a compound of Formula I and at least one biocontrol agent may be used in a wide variety of weight ratios. For example, in a two-component mixture, the weight ratio of a compound of Formula I to a biocontrol agent, the weight ratios in Table Al may be used.

[0136] In various aspects, a compound of Formula I-B and at least one biocontrol agent may be used in a wide variety of weight ratios. For example, in a two-component mixture, the weight ratio of a compound of Formula I-B to a biocontrol agent, the weight ratios in Table A2 may be used. However, in general, weight ratios less than about 10: 1 to about 1: 10 are preferred.

[0137] Weight ratios of a mixture of a compound of Formula I to another biocontrol agent may also be depicted as X:Y; wherein X is the parts by weight of a compound of Formula I and Y is the parts by weight of the biocontrol agent. The numerical range of the parts by weight for X is 0 < X < 100 and the parts by weight for Y is 0 < Y < 100 and is shown graphically in Table Bl. By way of non-limiting example, the weight ratio of a compound of Formula I to a biocontrol agent may be 20: 1.

[0138] Ranges of weight ratios of a compound of Formula I to a biocontrol agent may be depicted as Xr.Yi to X2X2, wherein X and Y are defined as above.

[0139] Weight ratios of a mixture of a compound of Formula I-B to another biocontrol agent may also be depicted as X:Y; wherein X is the parts by weight of a compound of Formula I-B and Y is the parts by weight of the biocontrol agent. The numerical range of the parts by weight for X is 0 < X < 100 and the parts by weight for Y is 0 < Y < 100 and is shown graphically in Table B2. By way of non-limiting example, the weight ratio of a compound of Formula I-B to a biocontrol agent may be 20: 1.

[0140] Ranges of weight ratios of a compound of Formula I-B to an active ingredient may be depicted as Xr.Yi to X2X2, wherein X and Y are defined as above.

[0141] In one aspect, the range of weight ratios may be Xr.Yi to X2X2, wherein Xi > Yi and X2 < Y2. By way of non-limiting example, the range of a weight ratio of Formula I to a biocontrol agent may be between 3: 1 and 1 :3, inclusive of the endpoints. By way of non-limiting example, the range of a weight ratio of Formula I-B to a biocontrol agent may be between 3: 1 and 1 :3, inclusive of the endpoints.

[0142] In another aspect, the range of weight ratios may X .Yi to X2X2, wherein Xi > Yi and X2 > Y2. By way of non-limiting example, the range of weight ratio of Formula I to a biocontrol agent may be between 15:1 and 3: 1, inclusive of the endpoints. By way of nonlimiting example, the range of weight ratio of Formula I-B to a biocontrol agent may be between 15: 1 and 3: 1, inclusive of the endpoints.

[0143] In another aspect, the range of weight ratios may be X .Yi to X2X2, wherein Xi < Yi and X2 < Y2. By way of non-limiting example, the range of weight ratios of Formula I to a biocontrol agent may be between about 1 :3 and about 1 :20, inclusive of the endpoints. By way of non-limiting example, the range of weight ratios of Formula I-B to a biocontrol agent may be between about 1 :3 and about 1 :20, inclusive of the endpoints.

[0144] In various aspects, each one of the at least one biocontrol agent and also the compound of Formula I in the composition is present at a concentration of 10 nanogram per milliliter (ng / mL), 50 ng / mL, 100 ng / mL, 500 ng / mL, 1 microgram per milliliter (pg / mL), 10 pg / mL, 50 pg / mL, 75 pg / mL, 0.1 milligram per milliliter (mg / mL), 0.2 mg / mL, 0.3 mg / mL, 0.4 mg / mL, even 0.5 mg / mL. In various aspects, each one of the at least one biocontrol agent and also the compound of Formula I-B in the composition is present at a concentration of 10 ng / mL, 50 ng / mL, 100 ng / mL, 500 ng / mL, 1 pg / mL, 10 pg / mL, 50 pg / mL, 75 pg / mL, 0.1 mg / mL, 0.2 mg / mL, 0.3 mg / mL, 0.4 mg / mL, even 0.5 mg / mL. In some aspects, at least one biocontrol agent and a compound of Formula I in the composition is present at a concentration of 1 mg / mL, 2 mg / mL, 3 mg / mL, 4 mg / mL or 5 mg / mL. In some aspects, at least one biocontrol agent and a compound of Formula I-B in the composition is present at a concentration of 1 mg / mL, 2 mg / mL, 3 mg / mL, 4 mg / mL or 5 mg / mL. In some aspects, at least one biocontrol agent and also the compound of Formula I in the composition is present at a concentration of 10 mg / mL, 20 mg / mL, 30 mg / mL, 40 mg / mL or 50 mg / mL. In some aspects, at least one biocontrol agent and also the compound of Formula I-B in the composition is present at a concentration of 10 mg / mL, 20 mg / mL, 30 mg / mL, 40 mg / mL or 50 mg / mL. In some aspects, at least one biocontrol agent and a compound of Formula I in the composition is present at a concentration of at least 100 mg / mL, 125 mg / mL, 150 mg / mL, 175 mg / mL, or 200 mg / mL. In some aspects, at least onebiocontrol agent and a compound of Formula I-B in the composition is present at a concentration of at least 100 mg / mL, 125 mg / mL, 150 mg / mL, 175 mg / mL, or 200 mg / mL.

[0145] In some other aspects, at least one biocontrol agent and a compound of Formula I in the composition is present at a concentration of at least 250 mg / mL. In some other aspects, at least one biocontrol agent and a compound of Formula I-B in the composition is present at a concentration of at least 250 mg / mL.

[0146] In some other aspects, at least one biocontrol agent and a compound of Formula I in the composition is present at a concentration from 0.1 mg / mL to 0.01 mg / mL. In some other aspects, at least one biocontrol agent and a compound of Formula I-B in the composition is present at a concentration from 0. 1 mg / mL to 0.01 mg / mL.

[0147] In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 1 : 100. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 1:100.

[0148] In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 10: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 10: 1.

[0149] In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 2: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1: 1 and about 2: 1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 3: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 3: 1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 4: 1. In certain aspects, the weight ratio of thecompound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 4: 1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 5: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 :1 and about 5:1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 6: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 6: 1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 :1 and about 7: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 7: 1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 8: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 8: 1. In certain aspects, the weight ratio of the compound of Formula I to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 9: 1. In certain aspects, the weight ratio of the compound of Formula I-B to each biocontrol agent at which the fungicidal effect is lies within the range of between about 1 : 1 and about 9: 1.

[0150] In some aspects the fungicidal compositions described herein may comprise, with respect to the composition, from about 1 gram active ingredient per liter (g ai / L) to about 10 kilograms active ingredient per liter (kg ai / L), from about 5 g ai / L to about 10 kg ai / L, from about 10 g ai / L to about 10 kg ai / L, from about 20 g ai / L to about 10 kg ai / L, from about 25 g ai / L to about 10 kg ai / L, from about 30 g ai / L to about 10 kg ai / L, from about 40 g ai / L to about 10 kg ai / L, from about 25 g ai / L to about 10 kg ai / L, from about 50 g ai / L to about 10 kg ai / L, from about 60 g ai / L to about 10 kg ai / L, from about 70 g ai / L to about 10 kg ai / L, from about 80 g ai / L to about 10 kg ai / L, from about 90 g ai / L to about 10 kg ai / L, from about 100 g ai / L toabout 10 kg ai / L, from about 200 g ai / L to about 10 kg ai / L, from about 500 g ai / L to about 10 kg ai / L, from about 750 g ai / L to about 10 kg ai / L, of the compound of Formula I. In some aspects the fungicidal compositions described herein may comprise, with respect to the composition, from about 1 gram active ingredient per liter (g ai / L) to about 10 kilograms active ingredient per liter (kg ai / L), from about 5 g ai / L to about 10 kg ai / L, from about 10 g ai / L to about 10 kg ai / L, from about 20 g ai / L to about 10 kg ai / L, from about 25 g ai / L to about 10 kg ai / L, from about 30 g ai / L to about 10 kg ai / L, from about 40 g ai / L to about 10 kg ai / L, from about 25 g ai / L to about 10 kg ai / L, from about 50 g ai / L to about 10 kg ai / L, from about 60 g ai / L to about 10 kg ai / L, from about 70 g ai / L to about 10 kg ai / L, from about 80 g ai / L to about 10 kg ai / L, from about 90 g ai / L to about 10 kg ai / L, from about 100 g ai / L to about 10 kg ai / L, from about 200 g ai / L to about 10 kg ai / L, from about 500 g ai / L to about 10 kg ai / L, from about 750 g ai / L to about 10 kg ai / L, of the compound of Formula LB.

[0151] In some aspects, the weight ratio of the biocontrol agent to the compound of Formula I is from 108: 1 to 1 : 106. In one aspect, the weight ratio of the biocontrol agent to the compound of Formula I is from 106: 10 to 1 : 100,000. In another aspect, the ratio of the biocontrol agent to the compound of Formula I is from 100,000:1 to 1 : 100. In yet another aspect, the ratio of the biocontrol agent to the compound of Formula I is from 1000: 1 to 1 : 10. In yet another aspect, the ratio of the biocontrol agent to the compound of Formula I is from 1000: 1 to 1 : 1. In yet another aspect, the ratio of the biocontrol agent to the compound of Formula I is from 500: 1 to 1:1.

[0152] In one aspect, the weight ratio of (a) the compound of Formula I to (b) the at least one biocontrol agent may be from 100,000: 1 to 1 : 100,000, from 100: 1 to 1 : 100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5,from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) the at least one biocontrol agent may be 1:1.

[0153] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) the at least one biocontrol agent may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1 :25, from 12:1 to 1 : 15, from 12:1 to 1 :5, from 12:1 to 1 :2, from 10:1 to 1 :20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) the at least one biocontrol agent may be 1:1.

[0154] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens QST713 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40,from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2: 1 to 1 : 5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens QST713 may be 1:1.

[0155] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens D747 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens D747 may be 1:1.

[0156] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens MBI600 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens MBI600 may be 1:1.

[0157] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens FZB24 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2: 1 to 1 : 5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens FZB24 may be 1:1.

[0158] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens PT A-4838 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2: 1 to 1 : 5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus amyloliquefaciens PTA-4838 may be 1:1.

[0159] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus subtilis^NQ may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1 :50, from 30:1 to 1 :40, from 30:1 to 1 :20, from 30:1 to 1:10, from 30:1 to 1 :5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1 :4, from 5:1 to 1 :2, from 3 : 1 to 1:10, from 3:1 to 1:8, from 3 : 1 to 1 :2, or from 2: 1 to 1 :5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus subtilis BV02 may be 1:1.

[0160] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus pumilus QST2808 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Bacillus pumilus QST2808 may be 1:1.

[0161] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Pseudomonas putida B2017 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1 :5, from 4:1 to 1 :4, from 3:1 to 1:3, from 2:1 to 1 :2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Pseudomonas putida B2017 may be 1:1.

[0162] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Pseudomonas chlororaphis AFS009 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Pseudomonas chlororaphis AFS009 may be 1:1.

[0163] In one aspect, the weight ratio of (a) the compound of Formula I to (b) the cell walls of Saccharomyces cerevisiae strain LAS117 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1 :45, from 40:1 to 1 :40, from 35:1 to 1 :35, from 30:1 to 1 :30, from 25:1 to 1 :25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1 :2, or from 2: 1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) the cell walls of Saccharomyces cerevisiae strain LAS 117 may be 1:1.

[0164] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Laminarin may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Laminarin may be 1:1.

[0165] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Reynoutria sachalinensis extract may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1 :40, from 35:1 to 1 :35, from 30:1 to 1 :30, from 25:1 to 1 :25, from 20:1 to 1 :20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Reynoutria sachalinensis extract may be 1:1.

[0166] In one aspect, the weight ratio of (a) the compound of Formula I to (b) salicylic acid may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) salicylic acid may be 1:1.

[0167] In one aspect, the weight ratio of (a) the compound of Formula I to (b) Acibenzolar-S- methyl may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I to (b) Acibenzolar-S-methyl may be 1:1.

[0168] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens QST713 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70,from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2: 1 to 1 : 5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens QST713 may be 1:1.

[0169] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillusmay be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1 :65, from 60:1 to 1 :60, from 55:1 to 1 :55, from 50:1 to 1 :50, from 45:1 to 1 :45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens D747 may be 1:1.

[0170] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens MBI600 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95,from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens MBI600 may be 1:1.

[0171] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillusmay be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1 :90, from 85:1 to 1 :85, from 80:1 to 1 :80, from 75:1 to 1 :75, from 70:1 to 1 :70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2: 1 to 1 : 5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens FZB24 may be 1:1.

[0172] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens PT A-4838 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000,from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus amyloliquefaciens PTA-4838 may be 1:1.

[0173] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus subtilis^NQ may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1 :1000, from 1 :1 to 1 :1000, from 1 :1 to 1 :500, from 100:1 to 1 :100, from 95:1 to 1 :95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus subtilis BV02 may be 1:1.

[0174] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus pumilus QST2808 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Bacillus pumilus QST2808 may be 1:1.

[0175] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) P seudomonas putida B2017 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Pseudomonas putida B2017 may be 1:1.

[0176] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Pseudomonas chlororaphis AFS009 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1 :2, or from 2: 1 to 1 :5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Pseudomonas chlororaphis AFS009 may be 1:1.

[0177] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) the cell walls of Saccharomyces cerevisiae strain LAS117 may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3 : 1 to 1 :2, or from 2: 1 to 1 : 5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) the cell walls of Saccharomyces cerevisiae strain LAS 117 may be 1:1.

[0178] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Laminarin may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1 :8, from 3:1 to 1 :2, or from 2:1 to 1 :5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Laminarin may be 1:1.

[0179] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Reynoutria sachalmensis extract may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to1:4, from 5:1 to 1:2, from 3:1 to 1:10, from 3:1 to 1:8, from 3:1 to 1:2, or from 2:1 to 1:5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Reynoutria sachalinensis extract may be 1:1.

[0180] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) salicylic acid may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from 65:1 to 1:65, from60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from 40:1 to 1:40, from35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from 15:1 to 1:15, from10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to 1:8, from 5:1 to 1:4, from 5:1 to 1 :2, from 3:1 to 1:10, from 3:1 to 1 :8, from 3:1 to 1 :2, or from 2:1 to 1 :5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) salicylic acid may be 1:1.

[0181] In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Acibenzolar-S-methyl may be from 100,000:1 to 1:100,000, from 100:1 to 1:100,000, from 10:1 to 1:1000, from 1:1 to 1:1000, from 1:1 to 1:500, from 100:1 to 1:100, from 95:1 to 1:95, from 90:1 to 1:90, from 85:1 to 1:85, from 80:1 to 1:80, from 75:1 to 1:75, from 70:1 to 1:70, from65:1 to 1:65, from 60:1 to 1:60, from 55:1 to 1:55, from 50:1 to 1:50, from 45:1 to 1:45, from40:1 to 1:40, from 35:1 to 1:35, from 30:1 to 1:30, from 25:1 to 1:25, from 20:1 to 1:20, from15:1 to 1:15, from 10:1 to 1:10, from 5:1 to 1:5, from 4:1 to 1:4, from 3:1 to 1:3, from 2:1 to 1:2, from 30:1 to 1:50, from 30:1 to 1:40, from 30:1 to 1:20, from 30:1 to 1:10, from 30:1 to 1:5, from 25:1 to 1:45, from 25:1 to 1:35, from 25:1 to 1:15, from 25:1 to 1:5, from 20:1 to 1:40, from 20:1 to 1:30, from 20:1 to 1:10, from 20:1 to 1:5, from 15:1 to 1:35, from 15:1 to 1:25, from 15:1 to 1:5, from 12:1 to 1:25, from 12:1 to 1:15, from 12:1 to 1:5, from 12:1 to 1:2, from 10:1 to 1:20, from 10:1 to 1:8, from 10:1 to 1:5, from 10:1 to 1:2, from 5:1 and 1:15, from 5:1 to1 :8, from 5: 1 to 1 :4, from 5: 1 to 1 :2, from 3: 1 to 1 : 10, from 3: 1 to 1:8, from 3: 1 to 1:2, or from 2: 1 to 1 :5. In one aspect, the weight ratio of (a) the compound of Formula I-B to (b) Acibenzolar- S-methyl may be 1 : 1.

[0182] In one aspect, the mixtures disclosed herein are present in an amount that exhibits enhanced efficacy.

[0183] Formulations

[0184] In one aspect, the disclosure provides for a fungicidal composition comprising a fungi cidally effective amount of the compound of Formula I and an agriculturally acceptable carrier.

[0185] In one aspect, the disclosure provides for a fungicidal composition comprising a fungi cidally effective amount of the compound of Formula I-B and an agriculturally acceptable carrier.

[0186] In one aspect, the disclosure provides for a fungicidal composition comprising a fungicidally effective amount of any one of the mixtures of any one of the previous aspects and an agriculturally acceptable carrier.

[0187] In one aspect, the mixtures disclosed herein are present at a weight ratio of a compound of Formula I to a biocontrol agent that exhibits enhanced efficacy in the composition.

[0188] In one aspect, the mixtures disclosed herein are present at a weight ratio of a compound of Formula I-B to a biocontrol agent that exhibits enhanced efficacy in the composition.

[0189] The present disclosure contemplates all vehicles by which the mixtures of this disclosure may be formulated for delivery and used as a fungicide. Typically, formulations are applied to plant foliage or to the root system, or the surrounding soil, or even to a seed, as aqueous suspensions or emulsions. Such suspensions or emulsions may be produced from water- soluble, water-suspendible, or emulsifiable formulations which are solids, usually known as wettable powders; or liquids, usually known as emulsifiable concentrates (EC), aqueous suspensions, or suspension concentrates (SC). Moreover, formulations such as suspensions (OD, FS), pastes, pastilles and gel formulations are within the scope of the compositions disclosedherein. In some aspects, the composition is diluted. In some aspects, the composition is undiluted.

[0190] As will be readily appreciated, any material to which any fungicide mixture of this disclosure can be added may be used, provided they yield the desired utility without significant interference with the activity of these compositions as antifungal agents.

[0191] Concentrated formulations may be dispersed in water, or other liquids, for application, or formulations may be dust-like or granular, which may then be applied without further treatment. The formulations can be prepared according to procedures that are known and conventional in the agricultural chemical art. Methods to make and use agricultural compositions comprising the compound of Formula I and at least one biocontrol agent can be found in, for example, references such as, Hance et al. Weed Control Handbook (8th ed., Blackwell Scientific, Oxford, 1989); Mollet, H. and Grubenmann, A.: Formulation Technology: Emulsions, Suspensions, Solid Forms (Wiley VCH Verlag, Weinheim, 2001); Perry's Chemical Engineers' Handbook (4th ed., McGraw-Hill, New York, 1963); Browning, et al. "Agglomeration" in Chemical Engineering, Dec. 4, 1967, 147-48; Klingman, Weed Control as a Science (J. Wiley & Sons, New York, 1961); and US 3,060,084, US 3,299,566, US 4,172,714, US 4,144,050, US 3,920,442, US 5,180,587, US 5,232,701, US 5,208,030, EP 707 445, GB 2,095,558, and WO91 13546, each of which is incorporated by reference in its entirety.

[0192] Wettable powders, which may be compacted to form water-dispersible granules, comprise a fungicide mixture of this disclosure, a carrier and agriculturally acceptable surfactants. The concentration of the fungicide mixture in the wettable powder is usually from about 10% to about 90% by weight, more preferably about 25% to about 75% by weight, based on the total weight of the formulation. In the preparation of wettable powder formulations, the fungicide mixture can be compounded with any of the finely divided solids, such as prophyllite, talc, chalk, gypsum, Fuller's earth, bentonite, attapulgite, starch, casein, gluten, montmorillonite clays, diatomaceous earths, purified silicates or the like. In such operations, the finely divided carrier is ground or mixed with the composition in a volatile organic solvent. Effective surfactants, comprising from about 0.5% to about 10% by weight of the wettable powder,include sulfonated lignins, naphthalenesulfonates, alkylbenzenesulfonates, alkyl sulfates, and nonionic surfactants, such as ethylene oxide adducts of alkyl phenols.

[0193] Some aspects of the disclosure provide a fungicidal composition - in any of the aspects described herein comprising a compound of Formula I and any at least one biocontrol agent - formulated in a composition of an emulsifiable concentrate ( .<?., an emulsion concentrate or EC) that contains an effective amount of the compound of Formula I.

[0194] Some aspects of the disclosure provide a fungicidal composition - in any of the aspects described herein comprising a compound of Formula I-B and any at least one biocontrol agent - formulated in a composition of an emulsifiable concentrate (z.e., an emulsion concentrate or EC) that contains an effective amount of the compound of Formula I-B.

[0195] Emulsifiable concentrates of a fungicide mixture of this disclosure comprise a convenient concentration of the fungicide mixture, such as from about 1% to about 50% by weight, in a suitable liquid, based on the total weight of the emulsifiable concentrate formulation. The components of the fungicide mixture, j ointly or separately, are dissolved in a carrier, which is either a water-miscible solvent or a mixture of water-immiscible organic solvents, and emulsifiers. The concentrates may be diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions.

[0196] Emulsifiers which can be advantageously employed herein can be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a blend of two or more emulsifiers. Examples of nonionic emulsifiers useful in preparing the emulsifiable concentrates include the polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as the ethoxylated alkyl phenols and carboxylic esters solubilized with the polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonium compounds and fatty amine salts. Anionic emulsifiers include the oil-soluble salts (e.g., calcium) of alkylaryl sulfonic acids, oil-soluble salts or sulfated polyglycol ethers and appropriate salts of phosphated polyglycol ether.

[0197] Representative organic liquids which can be employed in preparing the emulsifiable concentrates of the present disclosure are the aromatic liquids such as xylene, propyl benzenefractions, or mixed naphthalene fractions, mineral oils, substituted aromatic organic liquids such as dioctyl phthalate, kerosene, dialkyl amides of various fatty acids, particularly the dimethyl amides of fatty glycols and glycol derivatives such as the / / -butyl ether, ethyl ether or methyl ether of di ethylene glycol, and the methyl ether of tri ethylene glycol. Mixtures of two or more organic liquids are also often suitably employed in the preparation of the emulsifiable concentrate. The preferred organic liquids are xylene, and propyl benzene fractions, with xylene being most preferred. The surface-active dispersing agents are usually employed in liquid formulations and in the amount of from 0.1 to 20 percent by weight of the combined weight of the dispersing agent with the compositions. The formulations can also contain other compatible additives, for example, plant growth regulators and other biologically active compounds used in agriculture.

[0198] Aqueous suspensions comprise suspensions of one or more water-insoluble compounds, dispersed in an aqueous vehicle at a concentration in the range from about 5% to about 70% by weight, based on the total weight of the aqueous suspension formulation. Suspensions are prepared by finely grinding the components of the mixture either together or separately, and vigorously mixing the ground material into a vehicle comprised of water and surfactants chosen from the same types discussed above. Other ingredients, such as inorganic salts and synthetic or natural gums, may also be added to increase the density and viscosity of the aqueous vehicle. It is often most effective to grind and mix at the same time by preparing the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or pistontype homogenizer.

[0199] The composition may also be applied as a granular formulation, which is particularly useful for applications to the soil. Granular formulations usually contain from about 0.5% to about 10% by weight of the fungicides, based on the total weight of the granular formulation, dispersed in a carrier which consists entirely or in large part of coarsely divided attapulgite, bentonite, diatomite, clay or a similar inexpensive substance. Such formulations are usually prepared by dissolving the fungicide mixture in a suitable solvent and applying it to a granular carrier which has been pre-formed to the appropriate particle size, in the range of from about 0.5 to about 3 millimeters (mm). Such formulations may also be prepared by making a dough orpaste of the carrier and the composition and crushing and drying to obtain the desired granular particle.

[0200] Dusts containing the fungicide mixtures are prepared simply by intimately mixing the mixture in powdered form with a suitable dusty agricultural carrier, such as, for example, kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1% to about 10% by weight of the fungicide mixture / carrier combination.

[0201] The formulations may contain agriculturally acceptable adjuvant surfactants to enhance deposition, wetting and penetration of the composition onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will vary from 0.01 percent to 1.0 percent volume / volume (v / v) based on a spray-volume of water, preferably 0.05 to 0.5 percent. Suitable adjuvant surfactants include ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts or the esters of sulfosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines and blends of surfactants with mineral or vegetable oils.

[0202] In one aspect, the composition comprises a mixture comprising a compound of Formula I and at least one biocontrol agent. In one aspect, the composition comprises the mixture of at least one of the biocontrol agent and the compound of Formula I and a phytologically acceptable carrier. Preferably, the mixture of at least one of the biocontrol agent and the compound of Formula I of the present disclosure are applied in the form of a composition.

[0203] In various aspects, the phytologically acceptable carrier includes, but is not limited to, one or more of: solvents, dispersants, emulsifiers e.g. solubilizers, protective colloids, surfactants and adhesion agents, organic and inorganic thickeners, bactericides, anti-freezing agents, antifoaming agents, if appropriate colorants and tackifiers or binders (e.g. for seed treatment formulations).

[0204] In this context, suitable solvents for a formulation include water, alcohols such as methanol, ethanol, propanol, butanol or cyclohexanol, glycols, ketones such as cyclohexanone and gamma-butyrolactone, or a solvent such as mineral oil fractions of medium to high boiling point, kerosene or diesel oil, furthermore coal tar oils and oils of vegetable or animal origin,aliphatic, cyclic and aromatic hydrocarbons, e.g. toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalenes or their alkylated naphthalene derivatives, or a fatty acid or fatty acid dimethylamides, fatty acid esters and strongly polar solvents, e.g. amines such as N- methylpyrrolidone.

[0205] In various aspects, the phytologically acceptable carrier(s) is liquid. In various aspects, the phytologically acceptable carrier(s) is solid. In such aspects, a solid carrier may include, but is not limited to, magnesium sulfate, magnesium oxide, silicates, silica gels, lime, chalk, bole, loess, clays, dolomite, diatomaceous earth, talc, kaolins, limestone, calcium sulfate, fertilizers, such as, e.g., ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas, and materials such of like of cereal meal, tree bark meal, wood meal and nutshell meal, and cellulose powders.

[0206] The formulations may additionally contain other phytologically acceptable carriers, such as adjuvant surfactants to enhance deposition, wetting, and penetration of the compounds onto the target crop and organism. These adjuvant surfactants may optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will typically vary from 0.01 to 1 .0 percent by volume, based on a spray-volume of water, preferably 0.05 to 0.5 volume percent. Suitable adjuvant surfactants include, but are not limited to ethoxylated nonyl phenols, ethoxylated synthetic or natural alcohols, salts or the esters of sulfosuccinic acids, ethoxylated organosilicones, ethoxylated fatty amines, blends of surfactants with mineral or vegetable oils, crop oil concentrate (mineral oil (85%) + emulsifiers (15%)); nonylphenol ethoxylate; benzylcocoalkyldimethyl quaternary ammonium salt; blend of petroleum hydrocarbon, alkyl esters, organic acid, and anionic surfactant; C9 - Cl 1 alkylpolyglycoside; phosphated alcohol ethoxylate; natural primary alcohol (C12 - C16) ethoxylate; di-sec- butylphenol EO-PO block copolymer; polysiloxane-methyl cap; nonylphenol ethoxylate + urea ammonium nitrate; emulsified methylated seed oil; tridecyl alcohol (synthetic) ethoxylate (8EO); tallow amine ethoxylate (15 EO); PEG(400) dioleate-99. These types of formulations may also include oil-in-water emulsions, such are described, and the procedures to make them are explained in U.S. Patent Application Serial No. 11 / 495,228, the disclosure of which is hereby incorporated in its entirety by reference herein.

[0207] Bactericides may be added for preservation and stabilization of the composition. Examples for suitable bactericides are those based on dichlorophene and benzylalcohol hemi formal (Proxel® from ICI or Acticide® RS from Thor Chemie and Kathon® MK from Rohm & Haas) and isothiazolinone derivatives such as alkylisothiazolinones and benzisothiazolinones suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin.

[0208] Examples for anti-foaming agents are silicone emulsions (such as e.g. Silikon® SRE, Wacker, Germany or Rhodorsil®, Rhodia, France), long chain alcohols, fatty acids, salts of fatty acids, fluoroorganic compounds and mixtures thereof.

[0209] Suitable colorants are pigments of low water solubility and water-soluble dyes.

[0210] Examples to be mentioned und the designations rhodamine B, C. I. pigment red 1 12, C. I. solvent red 1, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15:1, pigment blue 80, pigment yellow 1, pigment yellow 13, pigment red 112, pigment red 48:2, pigment red 48: 1, pigment red 57: 1, pigment red 53: 1, pigment orange 43, pigment orange 34, pigment orange 5, pigment green 3.

[0211] In some aspects, the disclosure provides for fungicidal mixtures described herein, and / or compositions thereof, which are used either as “in-can” formulations or as tank biocontrol agent.

[0212] Example Formulation

[0213] Below is merely an example agricultural formulation that one skilled in the art could make with the formulation methods, the compounds and the carriers disclosed herein.

[0214] Suspensions formulation (either SC, OD, FS)

[0215] In an agitated ball mill, mix 20 parts by weight a mixture of the at least one biocontrol agent and a compound of Formula I with 20 parts by weight, each, of block copolymer of ethylene oxide and propylene oxide (e.g. Pluronic® P-105) and alkylnaphthalene sulfonate condensate sodium salt (e.g. Morwet® D-425) dispersing / wetting agents. Further, 60 parts by weight of fatty acid alkylester organic solvent is added and vigorous mixing gives a suspension concentrate. Dilution with water provides a stable suspension of the formulation. The at least one biocontrol agent and the compound of Formula I combined together is 40% by weight.

[0216] Methods of Use

[0217] In one aspect, the disclosure provides for a method of treating a plant for control of a disease and / or a fungal pathogen, wherein any one of the mixtures of any one of the previous aspects is applied to one of the plant, foliage of the plant, a plant seed, and an area adjacent to the plant.

[0218] In one aspect, the disclosure provides for a method of treating a plant for control of a disease and / or an undesirable fungal pathogen, wherein any one of the mixtures or compositions of any one of the previous aspects is applied to one of the plant, foliage of the plant, a plant seed, and an area adjacent to the plant. The mixture or composition disclosed herein may be used against a variety of diseases and / or a variety of Ascomycete and Basidiomycete fungi, including, for example, the following representative diseases and / or fungi species:

[0219] On cucurbits: powdery mildew (Erysiphe cichor acearum, Sphaerotheca fuliginea, Podosphaera xanthii), ring spot (Mycosphaerella brassicicola), blackleg (Plenodomus lingam), anthracnose (Colletotrichum higginsianum, Colletotrichum obiculare, Colletotrichum spp., Glomerella lagenarium), gummy stem blight (Mycosphaerella melonis, Didymella bryoniae, Stagonosporopsis cucurbitacearum), Alternaria leaf spot and blight Alternaria cucumerina, Alternaria alternata f. sp. cucurbitae, Alternaria spp.), Cercospora leaf spot (Cercospora citrullina, Cercospora spp.), Fusarium wilt (Fusarium oxysporum), belly rot (Rhizoctonia solani), Corynespora blight / target spot (Corynespora cassiicola), scab (Cladosporium cucumerinum), Verticillium wilt (Verticillium dahliae, Verticillium albo-atrum), black root rot (Thielaviopsis basicola), blue mold rot (Penicillium spp.), charcoal rot (Macrophomina phaseolina), and crater rot (fruit) (Myrothecium roridum),'

[0220] On tomato: powdery mildew (Leveillula taurica), Septoria leaf spot (Septaria lycopersici), white mold (Sclerotinia sclerotiorum, Sclerotinia minor), target spot (Corynespora cassiicola), southern blight (Sclerotium rolfsii), gray mold (Botrytis cinerea), gray leaf spot (Stemphylium spp.), Fusarium wilt, Fusarium crown and root rot (Fusarium oxysporum), anthracnose (Colletotrichum coccodes, Colletotrichum dematium, Colletotrichum gloeosporioides, Glomerella cingulate), Alternaria stem canker and black mold (Alternaria alternata), black root rot (Chalara elegans), Cercospora leaf mold (Cercospora fuligena), charcoal rot (Macrophomina phaseolina), corky root rot (Pyrenochaeta lycopersici), Didymellastem rot (Didymella lycopersici), early blight (Alternaria solani), leaf mold (Passalora fulva, Mycovellosiella fulva), phoma rot (Phoma destructiva), and sour rot (Geotrichum candidum),

[0221] On leafy vegetables: Cercospora leaf spot (Cercospora longissimi, Cercospora spp.), gray mold / Botrytis rot (Botrytis cinerea), Alternaria leaf spot and blight (Alternaria sonchi, Alternaria spp.), powdery mildew (Erysiphe cichoracearum, Golovinomyces cichoracearum, Uncinula spp.), rust (Puccinia dioicae), Septoria leaf spot (Septoria lactucae, Septaria spp.), southern blight (Sclerotium rolfsii), basal rot (Phoma exigua), Rhizoctonia bottom rot (Rhizoctonia solani), Sclerotinia drop (Sclerotinia minor, Sclerotinia sclerotiorum), and Stemphylium leaf spot (Stemphylium botryosuni),

[0222] On potato: anthracnose or black dot (Colletotrichum coccodes), brown spot and black pit (Alternaria alternata), Cercospora leaf blotch (Cercospora concors), charcoal rot (Macrophomina phaseolina), common rust (Puccinia pittieriana), deforming rust (Aecidium cantensis), early blight (Alternaria solani), Fusarium dry rot and Fusarium wilt (Fusarium spp.), gangrene (Phoma exigua f. v .foveata), gray mold (Botrytis cinerea), black blight or Phoma leaf spot (Stagonosporopsis andigena, Phoma andigena var. andinai), powdery mildew (Erysiphe cichoracearum), Rhizoctonia canker and black scurf (Rhizoctonia solani), Rosellinia black rot (Rosellinia spp .), Septoria leaf spot (Septoria lycopersici var. malagutil), silver scurf (Helminthosporium solani), skin spot (Polyscytalum pustulans), stem rot (Sclerotium rolfsii), Thecaphora smut (Thecaphora solani), Ulocladium blight (Ulocladium atrum), Verticillium wilt (Verticillium albo-atrum), and white mold (Sclerotinia sclerotiorum),

[0223] On peppers: southern blight (Sclerotium rolfsii , powdery mildew (Leveillula taurica), anthracnose (Colletotrichum capsici, Colletorichum acutatum, Colletorichum spp.), Cercospora (frogeye) leaf spot (Cercospora capsici, Cercospora spp.), charcoal rot (Macrophomina phaseolina), damping-off and root rot (Rhizoctonia solani), Fusarium stem rot (Fusarium solani), Fusarium wilt (Fusarium oxysporum f. sp. capsici), gray leaf spot (Stemphylium spp.), gray mold (Botrytis cinerea), Verticillium wilt (Verticillium albo-atrum), and white mold (Sclerotinia sclerotiorum),

[0224] On cole crops: Alternaria leaf spot and blight (Alternaria brassicicola, Alternaria spp.), Anthracnose (Colletotrichum spp.), black leg (Leptosphaeria maculans, Phoma lingam),Cercospora leaf spot (Cercopsora spp.), Fusarium yellows and other diseases (Fusarium spp.), gray mold / Botrytis blight Botrytis cinerea), powdery mildew Erysiphe polygoni), Rhizoctonia rot and blight (Rhizoctonia solani), ring spot (Mycosphaerella brassicicola), Sclerotinia rot (Sclerotinia spp.), white leaf spot (Pseudocercosporella capsellae),

[0225] On sugar beets: Alternaria leaf spot (Alter naria alternate, Alternaria brassicae), anthracnose (Colletrotrichum dematium), Aphanomyces root rot (Aphanomyces cochlioides), Cercospora leaf spot (Cercospora beticola), charcoal rot (Macrophomina paseaolina), Choanephora rot (Choanephora cucurbitarum), damping-off, black leg, black root, and seedling blight (Aphanomyces cochlioides, Cylindrocladium spp., Fusarium spp., Phoma betae, Pleospora betae, Rhizoctonia solani, Thanatephorus cucumeris), Fusarium yellows (Fusarium oxysporum), leaf gall / beet tumor / crown wart (Physoderma leproides), phoma leaf spot and root rot (Phoma betae), cotton root rot (Phymatotrichopsis omnivore), powdery mildew (Erysiphe polygoni, Erysiphe betae), Ramularia leaf spot (Ramularia beticola), Rhizoctonia foliar blight, crown rot, root rot (Rhizoctonia solani), Rhizopus root rot (Rhizopus arrhizus, Rhizopus stolonifera), rust (Uromyces betae), Sclerotinia crown and root rot (Sclerotinia sclerotiorum), seedling rust (Puccini subnitens), southern blight, Sclerotium root rot and stem rot (Sclerotium rolfsii), Stemphylium leaf spot (Stemphylium botryosum), storage rots (Botrytis cinerea, Penicillium spp., Phoma betae), Verticillium wilt (Verticillium albo-atrum) and violet root rot (Helicobasidium brebissonii),

[0226] On rice: Seedling Diseases - Seedling Blight (Cochliobolus miyabeanus, Curvularia spp., Fusarium spp., Rhizoctonia solani, Sclerotium rolfsii, Athelia rolfsii and others); Seed Box Diseases - Cochliobolus miyabeanus, Gibberella fujikuroi (anam. Fusarium moniliforme), Phoma exigua, Fusarium ssp., Pythium ssp., Rhizopus spp., Tricoderma viride, Rhizoctonia solani, Sclerotium rolfsii,' Foliar Diseases - blast (Magnaporthe grisea), brown spot (Cochliobolus miyabeanus), leaf scald (Monographella albescens, Microdochium oryzae, Rhynchosporium oryzae), narrow brown leaf spot (Sphaerulina oryzina, Cercospora janseana, Cercospora oryzae), stackburn or Alternaria leaf spot (Alternaria padwickii), leaf smut (Eballistra oryzae, Entyloma oryzae), eyespot (Drechslera gigantea), white leaf streak (Mycovellosiella oryzae), collar rot (Phomopsis oryzae-sativae), rusts (Puccinia graminis f. sp.oryzae, Uromyces coronatus), Sheath and Culm Diseases - stem rot (Magnaporthe salvinii, Sclerotium oryzae [synanamorph]), sheath blight (Thanatephorus cucumeris, Rhizoctonia solani [anamorph]), sheath spot (Waitea circinata, Rhizoctonia oryzae [anamorph]), aggregate sheath spot (Thanetephorus cucumeris, Rhizoctonia solani [anamorph]), Waitea circinata, Rhizoctonia oryzae [anamorph]), Ceratobasidium oryzae sativae, Rhizoctonia oryzae -sativae [anamorph]), sheath net blotch (Cylindrocladium scopariuni), sheath rot (Sarocladium oryzae), crown sheath rot (Gaeumannomyces graminis), Myrothecium blotch (Myrothecium verrucaria), sheath blotch (Pyrenochaeta oryzae); Root and Crown Diseases - bakanae (Gibberellafujikuroi, Fusarium moniliforme [anamorph]), root rots (Fusarium spp.); Grain Diseases - false smut (Villosiclava virens), Udbatta (Balansia oryzae-sativae), glume blight (Epicoccum sorghi), black kernel (Cochliobolus lunatus), minute leaf and grain spot (Cochliobolus miyabeanus), red blotch of grains (Epicoccum nigrum), ear blight (Cochliobolus miyabeanus, Sphaerulina oryzina, Cochliobolus lunatus, Monographella nivalis, Fusarium spp., Phoma spp., Monographella albescens, Magnaporthe salvinii, Cladosporoium spp., Epicoccum sp., Nigrospora spp.);

[0227] On soybean: Altemaria leaf spot (Alternaria spp.), anthracnose (Colletotrichum truncatum, Colletotrichum dematium f. truncatum, Glomerella glycines), black leaf blight (Arkoola nigra), black root rot (Thielaviopsis basicola, Chalara elegans), brown spot (Septoria glycines, Mycosphaerella usoenskajae), brown stem rot (Phialophora gregata, Cephalosporium gregatum), charcoal rot (Macrophomina phaseolina), Choanephora leaf blight (Choanephora infundibulifera, Choanephora trispora), damping-off, stem, root rot and aerial blight (Rhizoctonia solani, Thanatephorus cucumeris), Drechslera blight (Dr echsler a glycines), frogeye leaf spot (Cercospora sojina). Fusarium root rot (Fusarium spp.), Leptosphaerulina leaf spot (Leptosphaer ulina trifolii), Mycoleptodiscus root rot (Mycoleptodiscus terrestris), Neocosmospora stem rot (Neocosmospora vasinfecta, Acremonium spp.), Phomopsis seed decay (Phomopsis spp.), Phyllosticta leaf spot (Phyllosticta sojaecola), Phymatotrichum root rot, cotton root rot (Phymatotrichopsis omnivora, Phymatotrichum omnivorum), pod and stem blight (Diaporthe phaseolorum, Phomopsis sojae), powdery mildew (Microsphaera diffusa), purple seed stain (Cercospora kikuchii), Pyrenochaeta leaf spot (Pyrenochaeta glycines), red crown rot (Cylindrocladium crotalariae, Calonectria crotalariae), red leaf blotch, Dactuliophora leaf spot{Coniothyrium glycines, Dactuliochaeta glycines), rust {Phakopsora pachyrhizi), scab {Spaceloma glycines), Sclerotinia stem rot {Sclerotinia sclerotiorum), Southern blight, Sclerotium blight, damping-off and stem rot Sclerotium rolfsii, Athelia rolfsii), stem canker {Diaporthe phaseolornm, Diaporthe phaseolorum var. caulivora, Phomopsis phaseoli), Stemphylium leaf blight {Stemphylium botryosum, Pleospora tarda , sudden death syndrome {Fusarium virguliforme, Fusarium solani f. sp. glycines), target spot {Corynespora cassiicola), white mold {Sclerotinia sclerotiorum), yeast spot {Nematospora coryli)',

[0228] On corn: Anthracnose {Colletotrichum graminicola, Glomerella tucumanensis), Aspergillus ear and kernel rot {Aspergillus flavus), banded leaf and sheath spot {Rhizoctonia solani, Rhizoctonia microsclerotia), black bundle disease {Acremonium strictum, Cephalosporium acremonium), black kernel rot {Marasmiellus spp.), brown spot, black spot, stalk rot {Physoderma maydis), Cephalosporium kernel rot {Acremonium strictum, Cephalosporium acremonium), charcoal rot {Macrophomina phaseolina), Corticium ear rot {Thanatephorus cucumeris, Corticium sasakii), Curvularia leaf spot {Curvularia spp.), Didymella leaf spot {Didymella exitalis), Diplodia ear rot, stalk rot, leaf spot, leaf streak {Diplodia spp ), dry ear rot, cob, kernel and stalk rot {Nigrospora oryzae), ear rots {Alternaria spp., Aspergillus spp., Botrytis cinerea, Fusarium culmorum, Cunninghamella spp., Curvularia pallescens, Rhizopus spp., Gonatobotrys simplex, Doratomyces stemonitis, Cephalotrichum stemonitis, Pithomyces maydicus, Scopulariopsis brumptii), ergot {Claviceps gigantea), eyespot {Aureobasidium zeae, Kabatiella zeae), Fusarium kernel, root and stalk rot, seed rot, stalk rot, ear rot, and seedling blight {Fusarium spp., Gibberella spp.), gray ear rot {Botryosphaeria zeae, Physalospora zeae), gray leaf spot, Cercospora leaf spot {Cercospora sorghi, Cercospora zeae- maydis), Helminthosporium root rot {Exserohilum pedicellatum, Helminthosporium pedicellatum), Cladosporium rot {Cladosporium spp.), leaf spots {Alternaria alternata, Ascochyta maydis, Ascochyta tritici, Ascochyta zeicola, Bipolaris victoriae, Helminthosporium victoriae, Cochliobolus victoriae, Cochliobolus sativus, Bipolaris sorokiniana, Epicoccum nigrum, Exserohilum prolatum, Drechslera prolata, Graphium penicillioides, Leptosphaeria maydis, Leptothyrium zeae, Ophiosphaerella herpotricha, Paraphaeosphaeria michotii, Phoma spp., Septoria spp.), Northern com leaf blight {Setosphaeria turcica), white blast, stalk rot, stripe(Exserohilum turcicum, Helminthosporium turcicum), Northern corn leaf spot (Cochliobolus carbonum), Helminthosporium ear rot (Bipolaris zeicola, Helminthosporium carbonum , Penicillium ear rot, blue eye, blue mold (Pennicillium spp.), Phaeocytostroma stalk rot and root rot (Phaeocytostroma ambiguum, Phaeocytosporella zeae), Phaeosphaeria leaf spot (Phaeosphaeria maydis, Sphaerulina maydis), Physalospora ear rot, Botryosphaeria ear rot (Botryosphaeriafestucae, Physalospora zeicola), Pyrenochaeta stalk rot and root rot (Phoma terrestris, Pyrenochaeta terrestris), red kernel disease, ear mold, leaf and seed rot (Epicoccum nigrum), Rhizoctonia ear rot, root rot, stalk rot (Rhizoctonia spp ), root rots (Alternaria altemata, Cercospora sorghi, Dictochaeta fertilis, Fusarium spp., Gibberella spp., Microdochium bolleyi, Mucor spp., Periconia circinata, Rhizopus arrhizus) Rostratum leaf spot, Helminthosporium leaf disease, ear and stalk rot (Setosphaeria rostrata, Helminthosporium rostratum), rusts (Puccini a spp., Physopella spp.), brown rust of corn (Puccinia polysora), Sclerotium ear rot, Southern blight (Sclerotium rolfsii), seed rot-seedling blight (Bipolaris spp., Helminthosporium spp., Diplodia maydis, Exserohilum spp., Fusarium spp., Gibberella spp., Macrophomina phaseolina, Penicillium spp., Phomopsis spp., Rhizoctonia spp., Sclerotium rolfsii, Spicaria spp.), Selenophoma leaf spot (Selenophoma sp.), sheath rot (Gaeumannomyces graminis), shuck rot (Myrothecium gramineum), silage mold (Monascus spp.), smuts (Ustilago spp., Ustilaginoidea virens, Sphacelotheca reiliana, Sporisorium holci-sorghi). Southern corn leaf blight and stalk rot (Cochliobolus heterostrophus, Bipolaris maydis, Helminthosporium maydis), stalk rots (Cercospora sorghi, Fusarium spp., Nectria haematococca, Mariannaea elegans, Mucor spp., Rhopographus zeae, Spicaria spp.), storage rots (Aspergillus spp., Penicillium spp.), tar spot (Phyllachora maydis, Monographella maydis, Coniothyrium phyllachorae), Trichoderma ear rot and root rot (Trichoderma viride, Trichoderma lignorum, Hypocrea spp ), white ear rot, root and stalk rot (Stenocarpella maydis, Diplodia zeae), yellow leaf blight (Ascochyta ischaemi, Phyllosticta maydis, Mycosphaerella zeae-maydis) and Zonate leaf spot (Gloeocercospora sorghi),'

[0229] On barley: Anthracnose (Colletotrichum cereale Manns), barley stripe (Pyrenophora graminea), common root rot, crown rot and seedling blight (Cochliobolus sativus, Fusarium culmorum, Fusarium graminearum), dwarf bunt (Tilletia contr oversa), ergot (Clavicepspurpurea), eyespot (Pseudocercosoporella herpotrichoides), halo spot (Pseudoseptoria donacis), kernel blight Alternaria spp., Arthrinium arundinis, Cochliobolus sativus, Fusarium spp.), Ascochyta leaf spot (Ascochyta spp.), net blotch (Drechslera teres, Pyrenophora teres), powdery mildew (Erysiphe graminis fsp. hordei, Blumeria graminis), Rhizoctonia root rot (Rhizoctonia solani), crown rust (Puccinia coronata var. hordei , leaf rust (Puccinia hordei , stem rust (Puccinia graminis , stripe rust / yellow rust (Puccinia striiformis f. sp. hordei), scab / head blight (Fusarium spp.), Septoria speckled leaf blotch (Septoria passerinii, Stagonospora avenae fsp. triticae), sharp eyespot (Rhizoctonia cerealis), covered smut (Ustilago hordei)', false loose smut (Ustilago nigra), loose smut (Ustilago nuda), gray snow mold / Typhula blight (Typhula incarnata, Typhula ishikariensis), pink snow mold / Fusarium patch (Microdochium nivale), Ramularia leaf spot of barley (Ramularia collo-cygni), speckled snow mold (Typhula idahoensis), snow scald / Sclerotinia snow mold (Myriosclerotinia borealis, Sclerotinia borealis), southern blight (Sclerotium rolfsii), spot blotch (Cochliobolus sativus), Stagonospora blotch (Stagonospora avenae f.sp. triticae, Stagonospora nodorum, Septoria nodorum), take-all (Gaeumannomyces graminis var. tritici), tan spot (Pyrenophora tritici-repentis, Pyrenophora trichostoma) and Verticillium wilt (Verti ci Ilium dahliae),

[0230] On wheat: Alternaria leaf blight (Alternaria triticina), anthracnose (Glomerella graminicola, Colletotrichum graminicola), Ascochyta leaf spot (Ascochyta tritici), Aureobasidium decay Microdochium bolleyi, Aureobasidium bolleyi), black head molds, sooty molds Alternaria spp., Cladosporium spp., Epicoccum spp., Sporobolomyces spp., Stemphylium spp.), black point, kernel smudge (Alternaria spp., Cochliobolus sativus, Cladosporium spp.), Cephalosporium stripe (Hymenula cerealis, Cephalosporium gramineum), common bunt = stinking smut (Tilletia spp.), common root rot (Cochliobolus sativus, Bipolaris sorokiniana, Helminthosporium sativum), cottony snow mold (Coprinus psychromorbidus), crown rot, foot rot, seedling blight, dryland root rot (Fusarium spp., Gibberella spp.), Dilophospora leaf spot, twist (Dilophospora alopecuri), dwarf bunt (Tilletia controversa), ergot (Claviceps purpurea, Sphacelia segetum), eyespot, foot rot, strawbreaker (Tapesia yallundae, Ramulispora herpotrichoides, Pseudocercosporella herpotrichoides, Tapesia acuformis, Ramulispora acuformis, Pseudocercosporella herpotrichoides var. acuformis), false eyespot (Gibellinacerealis), flag smut (Urocystis agropyri), halo spot (Pseudoseptoria donacis, Selenophoma donacisy kamal bunt, partial bunt (Tilletia indica, Neovossia indica), rusts (Puccinia spp.), Leptosphaeria leaf spot (Phaeosphaeria herpotrichoides, Leptosphaeria herpotrichoides, Stagonospora), loose smut (Ustilago spp.), Microscopica leaf spot (Phaeosphaeria microscopica. Leptosphaeria microscopica), Phoma spot (Phoma spp.), pink snow mold, Fusarium patch (Microdochium nivale. Fusarium nivale, Monographella nivalis), Platyspora leaf spot (Clathrospora pentamera, Platyspora pentamera), powdery mildew (Erysiphe graminis f.sp. tritici, Blumeria graminis, Erysiphe graminis, Oidium monilioides), Rhizoctonia root rot (Rhizoctonia solani, Thanatephorus cucumeris), scab, head blight, Fusarium head blight (FHB) (Fusarium spp., Gibberella spp., Microdochium nivale, Monographella nivalis), Sclerotinia snow mold, snow scald (Myriosclerotinia borealis, Sclerotinia borealis), Sclerotium wilt, Southern blight, Sclerotium base rot (Sclerotium rolfsii, Athelia rolfsii), Septoria blotch (Septoria tritici, Mycosphaerella graminicola), sharp eyespot (Rhizoctonia cerealis, Ceratobasidium cereale), speckled snow mold, gray snow mold, Typhula blight (Typhula spp.), spot blotch (Cochliobolus sativus, Bipolaris sorokiniana, Helminthosporium sativum), Stagonospora blotch (Phaeosphaeria spp., Stagonospora spp., Septoria spp.), storage molds (Aspergillus spp., Penicillium spp.), take-all (Gaeumannomyces graminis), tan spot, yellow leaf spot, red smudge (Pyrenophora tritici-repentis, Drechslera tritici-repentis), tar spot (Phyllachora graminis, Linochora graminis) and wheat blast (Magnaporthe grisea),'

[0231] On pulse crops, including but not limited to peanut: Altemaria leaf blight and leaf spot (Alternaria spp.), anthracnose (Colletotrichum spp.), Aspergillus crown rot (Aspergillus niger), blackhull (Thielavi opsis basicola), Botrytis blight (Botrytis cinerea), Charcoal rot and Macrophomina leaf spot (Macrophomina phaseolina), Choanephora leaf spot (Choanephora spp.), Collar rot (Lasiodiplodia theobromae), Cylindrocladium black rot and leaf spot (Cylindr ocladium spp., Calonectria spp.), damping-off (Aspergillus spp., Fusarium spp., Rhizoctonia spp., Rhizopus spp.), Drechslera leaf spot (Bipolaris spicifera), Fusarium wilt and peg / root rot (Fusarium spp.), early leaf spot (Cercospora arachidicola), late leaf spot (Phaeoisariopsis personata, Cercosporidium personatum), melanosis (Stemphylium botryosum), Myrothecium leaf blight (Myrothecium roridum), Pepper spot and scorch (Leptosphaerulinacrassiasca), Pestalotiopsis leaf spot (Pestalotiopsis arachidis), Phoma leaf blight (Phoma microspore), Phomopsis foliar blight and leaf spot (Phomopsis spp.), Phyllosticta leaf spot Phyllosticta spp.), Phymatotrichum root rot (Phymatotrichopsis omnivore, Fusarium scirpi), pod rot (Fusarium spp., Rhizoctonia spp ), powdery mildew (Oidium arachidis), Rhizoctonia foliar blight, peg and root rot (Rhizoctonia solani), rust (Puccinia arachidis , scab (Sphaceloma arachidis), Sclerotinia blight (Sclerotinia spp.), stem rot / southern blight (Sclerotium rolfsii), Verticillium wilt (Verticillium spp.), web blotch / net blotch (Phoma arachidicola, Didymosphaeria arachidicola), yellow mold (Aspergiillus spp.), and zonate leaf spot (Cristulariella moricola),'

[0232] On other grain crops (including but not limited to rye, sorghum, oat, and triticale): Anthracnose (Colletotrichum spp.) black head molds (Alternaria spp., Cladosporium spp., Sporobolomyces spp., Stemphylium spp.), black point (Bipolaris spp., Fusarium spp ), bunt / stinking smut Tilletia spp.), Cephalosporium stripe (Hymenula cerealis), Common root rot and seedling blight (Bipolaris sorokiniana), winter crown rot (Coprinus psychromorbidus), Dilophospora leaf spot (Dilophospora alopecuri), dwarf bunt (Tilletia controversa), ergot (Claviceps purpurea), Fusarium root rot (Fusarium culmorum), halo spot (Pseudosept oria donacis), kamal bunt (Neovossia indica), leaf streak (Cercosporidium graminis , Leptosphaeria leaf spot (Phaeosphaeria herpotrichoides), loose smut (Ustilago tritici , pink snow mold (Fusarium spp.), powdery mildew (Erysiphe spp.), scab (Fusarium graminearum), Septoria leaf blotch and tritici blotch (Septoria spp.), sharp eyespot and Rhizoctonia root rot (Rhizoctonia cerealis), snow mold (Typhula spp.), spot blotch (Bipolaris sorokiniana), glume blotch (Septoria nodorum), stalk / stripe smut (Urocystis occulta , stem rust (Puccinia graminis), eyespot / foot rot (Pseudocercosporella herpotrichoides), stripe rust (Puccinia striiformis), crown rust (Puccinia coronota), brown rust (Puccinia recondita f. sp. recondita), black rust of bentgrass (Puccinia graminis subsp. Graminicola), stem rust of bluegrass (Puccinia graminis f. sp. poae), black mould (Cladosporium herbarum , take-all (Gaeumannomyces graminis), and tan spot (Pyrenophora tritici-repentis) ;

[0233] On stone and pome fruits: leaf spot (Mycosphaerella cersella, Mycosphaerella pyri, Cercospora rubrotincta), anthracnose (Glomerella cingulata, Glomerella acutata), leaf spot ofcherry {Blumeriella jaapii), powdery mildew {Podosphaeria leucotricha, Podosphaeria pannosa), Alternaria rot / black spot {Alternaria alternata, A. gaisen), gummosis {Botryosphaeria spp.), fruit rot {Botrytis cinerea , scab Venturia inequalis, V. pirinia, V. carpophila, V nashicola, Venturia spp ), southern blight {Sclerotium rolfsii), black rot {Botryosphaeria obtusa), Alternaria blotch and rot {Alternaria mali, Alternaria spp.), cedar apple rust {Gymnosporangium juniper-virginianae), American hawthorn rust {Gymnosporagium globosum), Japanese pear rust {Gymnosporangium asiaticum), European pear rust {Gymnosporangium sabinae), Kern’s pear rust {Gymnosporangium kernianum), pacific coast pear rust {Gymnosporangium Hbocedri), Rocky Mountain pear rust {Gymnosporangium nelsoni), bitter rot {Colletotrichum spp.), white rot {Botryosphaeria dolhidea black rot {Diplodia seriatd), sooty blotch and flyspeck (pathogen complex including Dothideomycetes and Sordariomycetes), Fabraea leaf spot {Fabraea maculata, Diplocarpon mespi ), brown spot {Stemphylium vesicarium), Brooks fruit spot {Mycosphaerella pomi), Phoma leaf and fruit spot {Phoma spp.), blotch {Phyllosticta solitarid), black pox and blister canker {Ellisembia asterinum), apple ring spot {Botryosphaeria spp.), calyx-end rot {Sclerotinia sclerotiorum), Monilinia leaf blight and brown rot {Monilinia spp.), Marssonina blotch {Diplocarpon malty blue mold {Penicillium spp.), gray mold {Botrytis cinerea), and canker and wood rot diseases {Neonectria spp., Neofabraea spp., Diaporthe spp., Valsa spp., Botryosphaeria spp., Armilllaria spp., Chondrostereum spp., Schizophylum spp., Stereum spp., Trametes spp.);

[0234] On grapes: black rot {Guignardia bidwellii, Phyllosticta ampelicida), bitter rot {Greeneria uvicold), Eutypa dieback {Eutypa lata), Botryosphaeria dieback and Macrophoma rot {Botryosphaeria spp. Botrytis bunch rot and blight {Botrytis cinerea), Phomopsis cane and leaf spot {Phomopsis viticola, Cryptosporella viticola), Rotbrenner {Pseudopezicula tracheiphila, Pseudopeziza tracheiphila), anthracnose {Elsinoe ampelina), rust {Phakopsora ampelopsidis, Phakopsora euvitis), Septoria leaf spot {Septaria ampelina), leaf blight {Pseudocercospora vitis), leaf blotch {Briosia ampelophaga), powdery mildew {Erysiphe necator), white rot {Coniella diplodiella, Pilidiella diplodiella), ripe rot {Colletotrichum spp ), berry rots and molds {Alternaria spp., Cladosporium spp., Botrytis cinerea, Colletotrichum spp., Diplodia spp.,Greeneria sp / ?., Phomopsis spp., Aspergillus spp., Penicillium spp., Rhizopus spp., Fusarium spp., Stemphyilium spp., Ascochyta spp.);

[0235] On strawberries: Septoria hard rot and leaf spot (Septoria spp.), powdery mildew (Sphaerotheca macularis, Podosphaera macularis), anthracnose (Colletotrichum spp.), common leaf spot (Mycosphaerella fragariae), Cercospora leaf spot (Cercospora spp.), leaf rust (Phragmidium potentillae, Frommeella tormentillae), Sclerotinia crown and fruit rot (Sclerotinia sclerotiorum), Altemaria fruit rot and black leaf spot (Alternaria spp.), anther and pistil blight / black root rot / hard brown rot (Rhizoctonia spp.), charcoal rot (Macrophomina phaseolina), Coniothyrium diseases (Coniothyrium fuckelii, Coniella fragariae), Dematophora crown and root rot / white root rot (Rosellinia necatrix), Diplodina rot / leaf and stalk rot (Phoma lycopersici), fruit rots (Aspergillus niger, Cladosporium spp., Penicillium spp.), Byssochlamys rot (Byssochlamys fulva), Fruit blotch (Peronospora potentillae, Sphaeropsis malorum, Sclerotium rolfsii, Schizoparme straminea), Gray mold leaf blight and dry crown rot (Botrytis cinerea), leaf scorch (Diplocarpon earlianum), Pestalotia fruit rot (Pestalotia sp.), Leaf blight (Phomopsis obscurans), Postharvest rots (Botrytis cinerea, Pichia spp., Saccharomyces spp.), southern blight (Sclerotium rolfsii),

[0236] On durian: Phytophthora spp (rot and dieback) and anthracnose (Colletotrichum spp);

[0237] On bananas: Anthracnose (Colletotrichum musae, Armillaria corn rot (Armillaria mellea, Armillaria tabescens), Black cross (Phyllachora musicola), Black root rot (Rosellinia bunodes), Black Sigatoka (Mycosphaerella fijiensis), Brown blotch (Pestalotiopsis leprogena), Brown spot (Cercospora hayi), Ceratocystis fruit rot (Ceratocystis paradoxa), Cigar-end (Verticillium theobromae, Trachysphaera fructigena), Cladosporium speckle (Cladosporium musae), Corm dry rot (Junghuhnia vincta), Cordana leaf spot (Cordana johnstonii, Cordana musae), Crown rot (Colletotrichum musae, Verticillium theobromae, Fusarium spp., Acremonium spp.), Cylindrocladium root rot (Cylindr ocladium spp.), Deightoniella fruit speckle, damping off, leaf spot and tip rot (Deightoniella torulosa), Diamond spot (Cercospora hayi, Fusarium spp ), Dwarf Cavendish tip rot (Nattrassia mangiferae), Eyespot (Drechslera gigantean), Fruit freckle (Guignardia musae , Fruit rot (Botryosphaeria ribis), Fungal root-rot (Fusarium spp., Rhizoctonia spp.), Fungal scald (Colletotrichum musae , Leaf rust (Uredomusae, Uromyces musae), Leaf speckle (Acrodontium simplex) Leaf spot (Curvularia eragrostidis, Drechslera musae-sapientum, Leptosphaeria musarum, Pestalotiopsis disseminata), Main stalk rot (Ceratocystis paradoxa), Malayan leaf spot (Haplobasidion musae), Marasmiellus rot Marasmiellus inoderma), Panama disease (Fusarium oxysporum f. sp. cubense), Peduncle rot (Lasiodiplodia theobromae, Fusarium spp., Verticillium theobromae), Pestalotiopsis leaf spot (Pestalotiopsis palmarum), Phaeoseptoria leaf spot (Phaeoseptoria musae , Pitting (Pyricularia grisea), Pseudostem heart rot (Fusarium moniliforme), Root & rhizome rot (Cylindrocarpon musae), Sclerotinia fruit rot (Sclerotinia sclerotiorum), Septoria leaf spot (Septoria eumusae), Sheath rot (Nectria foliicola, Mycosphaerella musicola), Sooty mold (Limacinula tenuis), Speckle (Mycosphaerella musae), Black end disease (Nigrospora sphaerica), Stem-end rot (Colletotrichum musae), Tropical speckle (Ramichloridium musae), Verticillium tip rot (Verticillium theobromae), and Yellow Sigatoka (Mycosphaerella musicola),

[0238] On turfgrasses: Anthracnose (Glomerella graminicola, Colletotrichum graminicola), Ascochyta leaf blight (Ascochyta spp.), Brown and Large patch (Rhizoctonia solani), Brown ring patch (Waitea circinata), Copper spot (Gloeocercospora sorghi), Dead spot (Ophiosphaerella agrostis), Dollar spot (Sclerotinia homoeocarpa), Fairy ring (Agaricus spp., Lepiota spp., Marasmius oreades, Lycoperdon spp., Agrocybe pediades, etc.), Gray leaf spot (Pyricularia grisea), Gray snow mold (Typhula spp.), Leaf spot and Melting out (Drechslera spp., Bipolaris spp.), Leaf and sheath spot (Waitea circinata var. zeae, Waitea circinata var. oryzae), Necrotic ring spot (Ophiosphaerella spp ), Pink patch (Limonomyces roseipellis), Pink snow mold (Microdochium nivale), Powdery mildew (Blumeria graminis), Pythium blight (Pythium spp.), Red leaf spot (Drechslera (Pyrenophora) erythrospila). Red thread (Laetisaria fuciformis), Rust diseases (Puccinia spp.), Smut diseases (Ustilago spp.), Spring dead spot (Ophiosphaerella korrae, O. herpotrich, O. narmari), Summer patch (Magnaporthe poae), Take-all patch (Gaeumannomyces graminis), Yellow patch (Rhizoctonia cerealis), and Yellow tuft (Sclerophthora macrospora)

[0239] On avocado: Stem Anthracnose (Colletotrichum gloeosporioides), Sooty Mold ( accospora spp ), Scab Disease (Sphaceloma perseae), Cercospora Spot or Blotch (Cercospora purpurea), powdery mildew (Oidium sppi), Stem end rot (Diplodia natalensis Polo Evans,Phomopsis spp. and Dothiorella spp., Colletotrichum), Phomopsis (syn. Diaporthe) and Botryosphaeria, Phytophthora root rot (Phytophthora cinnamomi), scab (Sphaceloma persea), anthracnose (Colletotrichum gloeosporioides, C. acutatum, C. acutatum, C. Fioriniae) and Cercospora spot (Pseudocercospora purpurea),

[0240] On almond: Brown rot blossom blight (Monilinia laxa, Monilinia fructicola), Shot hole (Wilsonomyces carpophilus), Anthracnose (Colletotrichum acutatum), Alternaria leaf spot (Alternaria alternata), Scab (Cladosporium carpophilum), Leaf rust (Tranzschelia discolor), Powdery mildew (Podosphaera tridactyla), Hull rot (Monilinia spp., Rhizopus stolonifer), Cytospora canker (Cytospora spp.), Botryosphaeria canker and blight (Botryosphaeria dothidea), Sclerotinia blossom blight (Sclerotinia sclerotiorum), Green fruit rot (Botrytis cinerea), Aspergillus rot (Aspergillus flavus, Aspergillus niger), Pink rot (Trichothecium roseurn), Armillaria root rot (Armillaria mellea), Phytophthora root and crown rot (Phytophthora spp.), Verticillium wilt (Verticillium dahliae);

[0241] On dragon fruit: Anthracnose (Colletotrichum gloeosporioides), Stem Canker (CeoscyiaHdium dimidiatum), Brown Spot (Neoscytalidium dimidiatum), fruit spots (Botryosphaeria dothidea; Bipolaris cactivora).

[0242] On citrus: Citrus black spot (Phyllosticta citricarpa, syn. Guignardia citricarpa), Citrus scab (Elsinoe fawcettii, E. australis), Melanose (Diaporthe citri, syn. Phomopsis citri), Greasy spot (Mycosphaerella citri, syn. Zasmidium citri-griseum), Alternaria brown spot (Alternaria alternata pv. citri), Anthracnose (Colletotrichum gloeosporioides, C. acutatum), Citrus black rot (Alternaria citri). Gummosis (Foot rot, Root rot, Phytophthora nicotianae, P. citrophthora, P. palmivora), Septoria spot (Septoria citri), Botrytis gray mold (Botrytis cinerea), Phytophthora brown rot (Phytophthora spp.), Diplodia stem-end rot (Diplodia natalensis, syn. Lasiodiplodia theobromae), Pink disease (Corticium salmonicolor), Postharvest fruit rots of citrus (Phytophthora spp., Diaporthe citri, Penicillium spp., Physalospora rhodina, Colletotrichum gloeosporioides), Sooty mold (Capnodium sp., Septobasidium spp., Aschersonia aleyrodis).

[0243] On coffee: Coffee leaf rust (Hemileia vastatrix), Coffee berry disease (CDB, Colletotrichum kahawae), Coffee wilt disease (Fusarium xylarioides), Coffee leaf spot (Browneye spot, Cercospora coffeicola), Coffee leaf blight (Phoma costar rice nsis), Coffee anthracnose (Colletotrichum gloeosporioides), Coffee trunk canker (Colletotrichum gloeosporioides), Coffee black rot (Rosellinia bunodes), Armillaria root rot, (Armillaria mellea), Coffee berry blotch (Mycena citricolor, syn. Crinipellis perniciosa). Ascochyta blight of coffee (Ascochyta coffeae), Coffee black rot (Botryosphaeria dothidea), Blue mold (Penicillium spp.), Soft rot of coffee (Rhizopus spp.), Green mold of coffee (Aspergillus spp ), Fusarium wilt of coffee (Fusarium oxysporum f. sp. coffea), Verticillium wilt of coffee (Verticillium dahliae), Rosellinia root rot of coffee (Rosellinia pepo), Armillaria root rot of coffee (Armillaria mellea).

[0244] On oilseed rape: White mould (Sclerotinia sclerotiorum), Grey mould (Botryotinia fuckeliana (anamorph Botrytis cinerea)), Black spot of rape (Alternaria brassicae), Phoma leaf spot / black leg / canker (Plenodomus lingam, Leptosphaeria maculans), Stem canker (Plenodomus biglobosus, Leptosphaeria biglobosa), Downy mildew (Hyaloperonospora parasitica, Peronospora parasitica), Powdery mildew (Erysiphe crucifer arum), Light leaf spot (Pyrenopeziza brassicae), White leaf spot (Neopseudocercosporella capsellae, P seudocercosporella capsellae), Club root (Plasmodiophora brassicae).

[0245] On sorghum: Anthracnose (Colletotrichum sublineola, C. graminicola), Rust (Puccinia purpurea), Leaf Blight (Exserohilum turcicum), Sorghum grain mould (Fusarium semitectum and F. moniliforme), Curvularia lunata) Sooty stripe (Ramulispora sorgi and Ramulispora andropogonis), Head smut (Sporisorium reilianum), charcoal rot (Macrophomina phaseolina), Sorghum Ergot (Claviceps africana, C. sorgln). Leaf spot (Alternaria alternata and Colletotrichum sublineola).

[0246] On cotton: Fusarium wilt (Fusarium oxysporum f. sp. vasinfectum), Verticillium wilt (Verticillium dahliae), Ramulosis (Colletotrichum gossypii var. cephalosporioides), Areolate leaf spot (Ramulispora areola, syn. Ramularia areola), Boll rot (Sclerotinia rot, Sclerotinia sclerotiorum), Boll rot (Rhizoctonia rot, Rhizoctonia solani), Boll rot (Pythium rot, Pythium spp.), Anthracnose (Colletotrichum gossypii), Alternaria leaf spot (Alternaria macrospora, A. alternata Alternaria spp), Ascochyta blight (Ascochyta gossypii), Cercospora leaf spot (Cercospora gossypina), Diplodia boll rot (Diplodia gossypina), Stemphylium leaf spot(Stemphylium solani), Rust (Phakopsora gossypii) Myrothecium leaf spot Myrothecium roridum), Target spot (Corynespora cassiicola).

[0247] On ornamental crops (for example, rose, chrysanthemum, tulips): Black spot (Diplocarpon rosae), Powdery mildew (Sphaerotheca pannosa var. Rosae), Botrytis (Botrytis cinerea), Rust (Phragmidium tuberculatum), Anthracnose (Sphaceloma rosarum).

[0248] On bulbs: black mould (Aspergillus niger), black stalk rot (Stemphylium botryosum), Botrytis Botrytis cinerea), Basal rot Fusarium oxysporum f sp. Cepae), Leaf blight (Botrytis squamosa), Neck rot (Botrytis allii), Leaf spot (Cladosporium allii-cepae), Pink root (Setophoma terrestris), Purple blotch (Alternaria porri), Rust Puccinia allii), Anthracnose (Colletotrichum circinans), Southern blight (Sclerotium rolfsii), Colletotrichum gloeosporioides, White tip (Phytophthora porri), White Rot (Sclerotium cepivorum).

[0249] On sunflower: Stem canker of sunflower (Diaporthe helianthi (anamorph Phomopsis helianthi)), White mould (Sclerotinia sclerotiorum), Grey mould (Botryotinia fuckeliana (anamorph Botrytis cinerea)), Downy mildew (Plasmopara halstedii), Black stem of sunflower (Plenodomus lindquistii, Leptosphaeria lindquistii (anamorph Phoma macdonaldi), Blight of sunflower (Alternariaster (Alternaria) helianthiri), Leaf spot of sunflower (Alternaria helianthicola), Charcoal rot (Macrophomina phaseolina (known as Rhizoctonia bataticola)), Sunflower rust (Puccinia helianthi), Leaf spot of sunflower (Septoria helianthin).

[0250] On sugar cane: Red rot (Colletotrichum falcatum), Smut (Sporisorium scitamineum, syn. Ustilago scitaminea), Rust (Puccinia melanocephala), Brown rust (Puccinia melanocephala), Orange rust Puccinia kuehnii), Pineapple disease (Ceratocystis paradoxa, syn. Thielaviopsis paradoxa), Pokkah boeng (Fusarium verticillioides, F. sacchari), Eye spot (Bipolaris sacchari, syn. Helminthosporium sacchari), Ring spot (Leptosphaeria sacchari, syn. Leptosphaeria tompkinsii), Downy mildew (Peronosclerospora sacchari), Wilt (Fusarium sacchari, F. moniliforme), Fusarium rot of sugarcane (Fusarium spp.), Brown spot of sugarcane (Cercospora longipes), Red rot of sugarcane (Glomerella tucumanensis).

[0251] In some aspects, the mixture or composition disclosed herein may be used against a variety of diseases and / or a variety of Oomycetes, including, for example, the following representative diseases and / or Oomycetes species: Phytophthora diseases such as Phytophthorainfestans, Phytophthora megasperma, Phytophthora parasitica, Phytophthora cinnamomi and Phytophthora capsica, Pythium diseases such as Pythium aphanider malum, and diseases in the Peronosporaceae family such as Plasmopara viticola, Peronospora spp. (including Peronospora tabacina and Peronospora parasitica), Pseudoperonospora spp. (including Pseudoperonospora cubensis) and Bremia lactucae.

[0252] In some aspects, the disclosure provides for a method of controlling fungal attack on a plant, the method comprising contacting a seed, an area adjacent to the plant, soil adapted to support growth of the plant, a root of the plant, and / or foliage of the plant, with a phytologically acceptable amount of a mixture of any one of embodiments or aspects or in the Examples described herein, or an agricultural composition thereof. The mixtures may be useful both in a treatment or in a protectant and / or an eradicant fashion.

[0253] In some aspects, the disclosure provides for a method of controlling fungal attack on a plant, the method comprising contacting a seed, an area adjacent to the plant, soil adapted to support growth of the plant, a root of the plant, and / or foliage of the plant, with a fungicide composition comprising a phytologically acceptable amount of a mixture of any one of embodiments or aspects or in the Examples described herein and a carrier. The compositions may be useful both in a treatment or in a protectant and / or an eradicant fashion.

[0254] The present disclosure includes within its scope methods for control of fungal attack. These methods comprise applying to the locus of the fungus, or to a locus in which the infestation is to be prevented, a fungicidally effective amount of the composition disclosed herein.

[0255] The method according to any one of the previous aspects wherein the composition or mixture is applied at an application rate of between 20 g / ha to 3000 g / ha, based on the total amount of active ingredients in the composition.

[0256] In some aspects, the disclosure provides for methods wherein the composition carrier is one or more of a thickener, emulsifier, rheology agent, dispersant and / or solid carrier.

[0257] In some aspects, the present disclosure provides for a method of protecting a plant against attack by a phytopathogenic organism and / or a method of treating a plant infested by aphytopathogenic organism, wherein the provided compound inhibits one or more species of fungi at a minimum inhibitory concentration (MIC) of 0.1-2 pg / mL.

[0258] The composition of the present disclosure is suitable for treatment of plants at fungicidal levels, while exhibiting low phytotoxicity. The composition is useful in a protectant or eradicant fashion. The composition is applied by any of a variety of known techniques, either as the composition or as a formulation comprising the composition. For example, the compositions may be applied to the roots, seeds or foliage of plants for the control of various fungi, without damaging the commercial value of the plants. The composition is applied in the form of any of the generally used formulation types, for example, as solutions, dusts, wettable powders, flowable concentrates, or emulsifiable concentrates. These materials are conveniently applied in various known fashions.

[0259] The compositions of the present disclosure have a broad range of efficacy as a fungicide. The exact amount of the composition to be applied is dependent not only on the relative amounts of the components, but also on the particular action desired and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the composition. Thus, formulations containing the composition may not be equally effective at similar concentrations.

[0260] In some aspects, the disclosure provides for methods and / or processes that use mixtures and / or compositions as described herein. These mixtures and / or compositions are capable of preventing or curing, or both, diseases caused by Oomycetes and / or fungi of the classes Ascomycetes and Basidiomycetes. In accordance with this disclosure, compositions are provided along with methods for their use and in particular against certain pathogens.

[0261] The compounds of the present disclosure may be applied by any of a variety of known techniques, either as a mixture of the compounds or as formulations comprising the mixture of compounds. Further, the mixture or composition may be applied to the roots, seeds or foliage of plants for the control of various fungi, without damaging the commercial value of the plants. The materials may be applied in the form of any of the generally used formulation types, for example, as solutions, dusts, wettable powders, flowable concentrates, or emulsifiable concentrates.

[0262] The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally effective at similar concentrations.

[0263] In some aspects, the mixtures comprising compounds of Formula I and at least one biocontrol agent are effective for use in any amount. In some aspects, the mixtures comprising compounds of Formula I and at least one biocontrol agent are effective for use in an effective amount. In some aspects, the mixtures comprising compounds of Formula I and at least one biocontrol agent are effective for use in an agricultural composition in any amount. In some aspects, the mixtures comprising compounds of Formula I and at least one biocontrol agent are effective for use in in an agricultural composition in a phytologically acceptable amount. In some aspects, the mixtures comprising compounds of Formula I and at least one biocontrol agent are effective for use in in an agricultural composition in an effective amount.

[0264] In some aspects, mixtures comprising compounds of Formula I and at least one biocontrol agent are effective in use with plants in a phytologically acceptable amount. This amount will generally be from about 0.1 to about 1000 ppm (parts per million), with 1 to 500 ppm being preferred. The exact concentration of compound required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like. A suitable application rate is typically in the range from about 0.10 to about 4 pounds / acre (about 0.01 to 0.45 grams per square meter, g / m2).

[0265] The rate at which the composition is applied will depend upon the particular type of fungus to be controlled, the degree of control required and the timing and method of application. In general, the composition of the disclosure can be applied at an application rate of between about 20 grams per hectare (g / ha) and about 3000 g / ha based on the total amount of active ingredients in the composition.

[0266] In certain aspects, the composition is applied at an application rate of between about 65 grams per hectare (g / ha) and about 2300 g / ha based on the total amount of active ingredients in the composition.

[0267] In certain aspects, the composition is applied differentially with respect to the actives. In certain aspects, Bacillus amyloliquefaciens QST713 is applied at a rate between about 30 g / ha and about 125 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens D747is applied at a rate between about 50 g / ha and about 200 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens MBI600 is applied at a rate between about 50 g / ha and about 250 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens FZB24 is applied at a rate between about 50 g / ha and about 250 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens PTA-4838 is applied at a rate between about 30 g / ha and about 125 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus subtilis BV02 is applied at a rate between about 100 g / ha and about 2000 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus pumilus QST2808 is applied at a rate between about 50 g / ha and about 200 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Pseudomonas putida B2017 is applied at a rate between about 50 g / ha and about 200 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Pseudomonas chlororaphis AFS009 is applied at a rate between about 20 g / ha and about 300 g / ha and the compound of Formula I is applied at a rate between about 35 g / ha and about 300 g / ha.

[0268] In certain aspects, the composition is applied differentially with respect to the actives. In certain aspects, Bacillus amyloliquefaciens QST713 is applied at a rate between about 30 g / ha and about 125 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens D747is applied at a rate between about 50 g / ha and about 200 g / ha and the compound of Formula I-B is applied at a rate'll between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens MBI600 is applied at a rate between about 50 g / ha and about 250 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens FZB24 is applied at a rate between about 50 g / ha and about 250 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus amyloliquefaciens PTA-4838 is applied at a rate between about 30 g / ha and about 125 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus subtilis BV02 is applied at a rate between about 100 g / ha and about 2000 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Bacillus pumilus QST2808 is applied at a rate between about 50 g / ha and about 200 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Pseudomonas putida B2017 is applied at a rate between about 50 g / ha and about 200 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha. In certain aspects, Pseudomonas chlororaphis AFS009 is applied at a rate between about 20 g / ha and about 300 g / ha and the compound of Formula I-B is applied at a rate between about 35 g / ha and about 300 g / ha.

[0269] The components of the mixture of the present disclosure can be applied either separately or as part of a multipart fungicidal system.

[0270] In some aspects, the use according to any one of the previous aspects wherein the biocontrol agent is applied at a rate between 20 g / ha and 3000 g / ha and the compound of Formula I is applied at a rate between 20 g / ha and 300 g / ha, based on the total amount of active ingredients in the composition.

[0271] The mixture or the composition according to any one of the previous aspects wherein the composition or mixture is applied at an application rate of between 20 g / ha to 3000 g / ha, based on the total amount of active ingredients in the composition.

[0272] The mixture or the composition according to any one of the previous aspects wherein the biocontrol agent is applied at a rate between 20 g / ha and 3000 g / ha and the compound ofFormula I-B is applied at a rate between 20 g / ha and 300 g / ha, based on the total amount of active ingredients in the composition.

[0273] The method according to any one of the previous aspects wherein the biocontrol agent is applied at a rate between 20 g / ha to 3000 g / ha and the compound of Formula I-B is applied at a rate between 20 g / ha and 300 g / ha, based on the total amount of active ingredients in the composition.

[0274] The method according to any one of the previous aspects comprising one biocontrol agent .

[0275] The method according to any one of the previous aspects comprising two biocontrol agent.

[0276] The method according to any one of the previous aspects wherein the weight ratio of the compound of Formula I to each a biocontrol agent is between about 1 : 1 and about 1 : 100.

[0277] The method according to any one of the previous aspects wherein the weight ratio of the compound of Formula I to each a biocontrol agent is between about 1 : 1 and about 10: 1.

[0278] The method according to any one of the previous aspects wherein the mixture comprises one biocontrol agent and the compound of Formula T; and wherein the biocontrol agent and the compound of Formula I have a different mode of activity.

[0279] The method according to any one of the previous aspects wherein the mixture comprises two biocontrol agent and the compound of Formula I; and wherein one biocontrol agent and the compound of Formula I have a different mode of activity.

[0280] The method according to any one of the previous aspects wherein the mixture comprises two biocontrol agents; and wherein the two biocontrol agents each have a different mode of activity.

[0281] The method according to any one of the previous aspects wherein the method further comprises contacting with a fungicidal composition comprising the mixture and an agriculturally acceptable adjuvant or carrier.

[0282] Seed Treatment

[0283] In some aspects, the disclosure provides for a seed treated with a mixture of a compound of Formula I and at least one biocontrol agent, as described herein, or an agriculturalcomposition thereof. In some aspects, the disclosure provides for a seed treated with a mixture of a compound of Formula I and at least one biocontrol agent, as described in any one of embodiments or aspects or in the Examples described herein, or an agricultural composition thereof. In some of these aspects, the amount of a compound of Formula I and at least one biocontrol agent or the amount of at least one biocontrol agent of any one of embodiments or aspects or in the Examples described herein is a phytologically acceptable amount. In some of these aspects, the amount of compound of Formula I and at least one biocontrol agent of any one of embodiments or aspects or in the Examples described herein is an effective amount.

[0284] In some aspects, the disclosure provides for a method of controlling fungal attack on a plant, the method comprising contacting a seed with a mixture of a compound of Formula I and at least one biocontrol agent, as described herein, or an agricultural composition thereof. In some aspects, the disclosure provides for a method of controlling fungal attack on a plant, the method comprising contacting a seed with a compound of any one of embodiments or aspects or as those mixtures and / or compositions described in the Examples, or an agricultural composition thereof. In some of these aspects, the amount of a mixture of a compound of Formula I and at least one biocontrol agent of any one of embodiments or aspects or in the Examples described herein is an effective amount.

[0285] The compositions are effective in use with plants in a disease-inhibiting and phytologically acceptable amount. The term "disease-inhibiting and phytologically acceptable amount" refers to an amount of the composition that kills or inhibits the plant disease for which control is desired, but is not significantly toxic to the plant. The exact concentration of composition required varies with the fungal disease to be controlled, the type of formulation employed, the method of application, the particular plant species, climate conditions, and the like.

[0286] The present compositions can be applied to fungi or their locus by the use of conventional ground sprayers, granule applicators, and by other conventional means known to those skilled in the art.

[0287] The following examples illustrate various aspects of the compositions described herein, but of course, should not be construed as limiting the claims.EXAMPLES

[0288] Fungicides were evaluated against PHAKPA either alone or in binary mixtures by combining each fungicide with the compound of Formula 1. Technical grade of the compound of Formula I was dissolved in acetone, which was then mixed with nine volumes of water containing 0.01% Tween-20. Biological materials were diluted in 0.01% Tween-20 and combined with the compound of Formula I. The fungicide solutions were applied onto soybean seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air-dry prior to further handling. Soybean plants (variety Williams 82) were grown in soil-less mix, with one plant per pot. Ten-day old seedlings were used for testing. Plants were inoculated either 3-days prior to or 1-day after fungicide treatments. Plants were incubated for 24 h in a dark dew room at 22°C and 100% RH then transferred to a growth room at 23°C for disease to develop.

[0289] Fungicides were also evaluated against SEPTTR either alone or in binary mixtures by combining each fungicide with the compound of Formula I. Technical grade of the compound of Formula I was dissolved in acetone, which was then mixed with nine volumes of water containing 0.01% Triton-X. Biological materials were diluted in 0.01% Triton-x and combined with the compound of Formula I. The fungicide solutions were applied onto wheat seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air-dry prior to further handling. Wheat plants (variety Yuma) were grown in soil-less mix, with 7-10 plants per pot. Ten- day old seedlings were used for testing. Plants were inoculated 1-day after fungicide treatments. Plants were incubated for 24 h in a dark dew room at 20°C and an additional 72 h in light and 100% RH then transferred to a greenhouse at 18°C for disease to develop.

[0290] Fungicides were also evaluated against BOTRC1 either alone or in binary mixtures by combining each fungicide with the compound of Formula I. Technical grade of the compound of Formula I was dissolved in acetone, which was then mixed with nine volumes of water containing 0.01 % Triton-X. Biological materials were diluted in 0.01% Triton-x and combined with the compound of Formula I. The fungicide solutions were applied onto grape seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air-dry prior to further handling. Grape plants (variety Pinot noir) were grown in soil-less mix, with 1 plant per pot. 5-6- week-old seedlings, trimmed to one leaf were used for testing. Plants were inoculated 1-day afterfungicide treatments. Plants were incubated for 4 days in a dark dew room at 22°C and 100% RH until time of rating.

[0291] Fungicides were also evaluated against COLLLA either alone or in binary mixtures by combining each fungicide with the compound of Formula I. Technical grade of the compound of Formula I was dissolved in acetone, which was then mixed with nine volumes of water containing 0.01% Triton-X. Biological materials were diluted in 0.01% Triton-X and combined with the compound of Formula I. The fungicide solutions were applied onto cucumber seedlings using an automated booth sprayer to run-off. All sprayed plants were allowed to air-dry prior to further handling. Cucumber plants (variety Straight eight) were grown in soil-less mix, with 1 plant per pot. 10 tol2-day old seedlings were inoculated 1-day after fungicide treatments. Plants were incubated for 48 hrs in a dark dew room at 22°C and 100% RH then transferred to a growth room at 23°C for disease to develop.

[0292] Once disease was fully expressed on untreated plants, disease severity was assessed on the sprayed first true leaves.

[0293] Factors (Obs / Exp) were calculated using Colby’s method. The expected disease control (%DC exp) of a mixture consisting of two components was predicted by the following formula: %DC exp = (X + Y) - (XY / 100) where X and Y are the percent disease control given by the individual fungicide component at the defined rate in the mixture. If the ratio (Factor (Obs / Exp)) between the observed disease control of the mixture (%DC obs) and the expected disease control of the mixture (%DC exp) is greater than 1, enhanced efficacy is present.

[0294] Controlled chamber studies were conducted where treatments were applied as either a 1-day protectant (1DP) or as a 3-day curative (3DC) against PHAKPA or 1-day protectant (1DP) against PHAKPA, SEPTTR, BOTRCI or COLLLA to evaluate interactions of the compound of Formula I and other biologicals.Example 1. Interactions between the compound of Formula I and Serenade ASO S' (Bacillus subtilis strain QST 713) were detected in curative and protectant treatments vs. PHAKPA (Tables 1 and 2) and / or protectant treatments vs. SEPTTR, BOTRCI and COLLLA (Tables 3, 4 and 5).Table 1. Interactions between the compound of Formula I and Serenade ASO® in 3-day curative (3DC) PHAKPA testTable 2. Interactions between the compound of Formula I and Serenade ASO® in 1-day protectant (1DP) PHAKPA testTable 3. Interactions between the compound of Formula I and Serenade ASO® in 1-day protectant (1 DP) SEPTTR test *Table 4. Interactions between the compound of Formula I and Serenade ASO® in 1-dayTable 5. Interactions between the compound of Formula I and Serenade ASO® in 1-day protectant (1 DP) COLLLA testExample 2. Interactions between the compound of Formula I and Double Nickel® (Bacillus amyloliquefaciens strain D747) were detected in protectant treatments vs. PHAKPA and / or SEPTTR and COLLLA (Tables 6, 7 and 8).Table 6. Interactions between the compound of Formula I and Double Nickel® in 1-day protectant (1DP) PHAKPA testTable 7. Interactions between the compound of Formula I and Double Nickel® in 1-day protectant ( 1DP) SEPTTR test *Table 8. Interactions between the compound of Formula I and Double Nickel® in 1-day protectant (1DP) COLLLA testExample 3. Interactions between the compound of Formula I and Howler® (Pseudomonas chlororaphis strain AFS009) were detected in protectant treatments vs. SEPTTR, BOTRCI and COLLLA (Tables 9, 10 and 11).Table 9. Interactions between the compound of Formula I and Howler in 1-day protectant (1DP)SEPTTR testTable 10. Interactions between the compound of Formula I and Howler® in 1-day protectant(1DP) BOTRCI testTable 11. Interactions between the compound of Formula I and Howler® in 1-day protectant(1DP) COLLLA testExample 4. Interactions between the compound of Formula I and Actigard® (Acibenzolar-S- methyl) were detected in protectant treatments vs. BOTRCI and COLLLA (Tables 12 and 13).Table 12. Interactions between the compound of Formula I and Actigard® in 1-day protectant(1DP) BOTRCI testTable 13. Interactions between the compound of Formula I and Actigard® in 1-day protectant(1DP) COLLLA testExample 5. Interactions between the compound of Formula I and Vacciplant® (purified polysaccharide from Laminaria digitata) were detected in protectant treatments vs. PHAKPA (Table 14).Table 14. Interactions between the compound of Formula I and Vacciplant® in 1-day protectant (1DP) PHAKPA testExample 6. Interactions between the compound of Formula I and Regalia® (extract of Giant Knotweed (Reynoutria sachalinensis ) were detected in protectant treatments vs. COLLLA (Table 15).Table 15. Interactions between the compound of Formula I and Regalia® in 1-day protectantExample 7. Interactions between the compound of Formula I and Romeo (Cerevisane (cell walls of Saccharomyces cerevisiae strain LAS 117)) were detected in protectant treatments vs.PHAKPA (Table 16).Table 16. Interactions between the compound of Formula I and Romeo in 1-day protectant (1DP) PHAKPA testTable 17. Conversion of product concentration (Cone.; %v / v or %w / v) to product rate.

[0295] All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference are individually and specifically indicated to be incorporated by reference and are set forth in its entirety herein.

[0296] Preferred embodiments of this disclosure are described herein, including the best mode known to the inventors for carrying out the embodiments. Variations of those preferred embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventors expect skilled artisans to employ such variations as appropriate, and the inventors intend for the invention to be practiced otherwise than as specifically described herein. Accordingly, this invention includes all modifications andequivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.

Claims

CLAIMSWhat is claimed is:A fungicidal mixture, comprising: a) a fungi cidally effective amount of the compound of Formula I:Formula I or an acceptable salt, solvate, or hydrate thereof; and b) at least one biocontrol agent selected from the group consisting of micro-organism, macro-organism, semiochemical, botanical, plant growth regulator, plant immunity inducers, and mixtures or blends thereof.

2. The mixture of claim 1, wherein the micro-organism is selected from the group consisting of Oomycetes, Bacillus bacteria, Pseudomonas bacteria, and mixtures or blends thereof.

3. The mixture of claim 2 wherein the Bacillus bacteria is selected from the group consisting of Bacillus amyloliquefaciens, Bacillus subtihs. Bacillus velezensis, Bacillus mycoides, Bacillus pumilus, and mixtures or blends thereof.

4. The mixture of claim 2 wherein the Pseudomonas bacteria is selected from the group consisting of Pseudomonas putida, Pseudomonas syringae, Pseudomonas aeruginosa, Pseudomonas Fluorescens, Pseudomonas chlororaphis, and mixtures or blends thereof.

5. The mixture of claim 3 wherein Bacillus bacteria is selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Bacillus amyloliquefaciens MBI600, Bacillus amyloliquefaciens FZB24, Bacillus amyloliquefaciens PTA-4838, Bacillus subtilis BV02, Bacillus pumilus QST2808, and mixtures or blends thereof.

6. The mixture of claim 4 wherein the Pseudomonas bacteria is selected from the group consisting of Pseudomonas putida B2017, Pseudomonas chlororaphis AFS009, and mixtures or blends thereof.

7. The mixture of claim 1, wherein the at least biocontrol agent is selected from the group consisting of Bacillus amyloliquefaciens QST713, Bacillus amyloliquefaciens D747, Pseudomonas chlororaphis AFS009, the cell walls of Saccharomyces cerevisiae strain LAS 117, Laminarin, Reynoutria sachalinensis extract, salicylic acid, methyl salicylate, and mixtures or blends thereof.

8. The mixture of claim 1 wherein the fungicidal mixture comprises two biocontrol agents.

9. Use of the mixture of any one of claims 1-8 for fungal control.

10. A method for control of fungal pathogen, wherein the mixture of claims 1-8 is applied to one of the plant, foliage of the plant, a plant seed, and an area adjacent to the plant.

11. A fungicidal composition comprising a fungicidally effective amount of the mixtures of Claims 1-8 and an agriculturally acceptable carrier.

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