Intravenous stimulation of dorsal root to affect organ function

Intravenous electrode systems deliver electrical stimulation to dorsal root nerve fibers via veins to address the challenges of dorsal root stimulation, enabling effective organ function modulation with reduced procedural pain and lead fracture risk.

WO2026110033A1PCT designated stage Publication Date: 2026-05-28MEDTRONIC INC
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
MEDTRONIC INC
Filing Date
2025-11-18
Publication Date
2026-05-28

AI Technical Summary

Technical Problem

Dorsal root stimulation for organ function modulation is challenging due to the complexity of the procedure, pain associated with lead placement through the foramen, susceptibility of leads to fracture, and potential exacerbation of foraminal stenosis, requiring multiple leads for effective stimulation.

Method used

Intravenous electrode systems and methods that deliver electrical stimulation to dorsal root nerve fibers through veins, such as the azygos, hemiazygos, and posterior intercostal veins, using implantable devices with processors to control the stimulation and activate afferent nerves for organ function modulation.

Benefits of technology

Easier electrode placement, reduced risk of lead fracture, and effective organ function modulation, including heart failure management, hypertension control, diabetes management, and inflammation reduction, by activating renal, cardiac, and pancreatic afferent nerves.

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Abstract

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.
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Citation Information

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