Methods of minimising the effects of dust exposure

AONs that modulate RAGE production effectively treat and prevent silicosis by reducing inflammation and fibrosis, and enhancing silica recovery during lung lavage, addressing the lack of effective therapies for this lung condition.

WO2026112695A1PCT designated stage Publication Date: 2026-06-04RAGE BIOTECH PTY LTD
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
RAGE BIOTECH PTY LTD
Filing Date
2025-11-27
Publication Date
2026-06-04

AI Technical Summary

Technical Problem

There is a need for new or improved methods to treat and prevent silicosis, a common cause of lung damage with no proven specific therapy to reverse or halt the disease process once it starts, affecting millions of workers globally due to exposure to crystalline silica.

Method used

Administering antisense oligonucleotides (AONs) that promote the production of endogenous soluble RAGE and/or reduce the production of membrane-bound RAGE to treat or prevent silicosis, potentially combined with whole lung lavage.

Benefits of technology

AONs reduce inflammation and fibrosis, minimize silica particle accumulation, and enhance silica recovery during lung lavage, offering a potential treatment or prevention method for silicosis.

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Abstract

The present invention relates to compositions, methods and kits for the treatment or prevention of a silicosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of acute silicosis or acute silicoproteinosis, complicated or conglomerate silicosis, accelerated silicosis or chronic silicosis. In one aspect, the present invention provides method of treating or preventing silicosis, or subtype thereof, in a subject in need thereof, the method comprising administering to the subject an antisense oligonucleotide (AON) that promotes the production of endogenous soluble RAGE, thereby treating or preventing silicosis, or subtype thereof, in a subject.
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