Spirocyclic annulated 2-amino-3-cyano thiophene derivatives as KRAS inhibitors for the treatment of cancer
Spirocyclic annulated 2-amino-3-cyano thiophene derivatives provide selective inhibition of KRAS mutants, addressing treatment resistance in cancers by enhancing metabolic stability and permeability, thereby inhibiting uncontrolled cellular proliferation.
WO2026114918A1PCT designated stage Publication Date: 2026-06-04BOEHRINGER INGELHEIM INT GMBH +1
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- BOEHRINGER INGELHEIM INT GMBH
- Filing Date
- 2025-11-26
- Publication Date
- 2026-06-04
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Figure EP2025084289_04062026_PF_FP_ABST
Abstract
The present invention encompasses compounds of formula (I) the compounds of formula (I) for use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and the compounds of formula (I) for use as medicaments / medical uses, especially as agents for treatment and / or prevention of oncological diseases.
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