Cosmetic composition

Abstract

Disclosed is a cosmetic composition comprising: (a) apricot oil; and (b) C7 to C30 hydroxy aromatic carboxylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of total component (b) to total component (a) is from 10:1 to 100:1; wherein said composition does not comprise guar hydroxypropyltrimonium chloride.

Description

[0001] COSMETIC COMPOSITION

[0002] Field of the Invention

[0003] The present invention relates to a cosmetic composition comprising: (a) apricot oil; and (b) C?to C30 hydroxy aromatic carboxylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of total component (b) to total component (a) is from 10:1 to 100:1 . It was surprisingly found that such composition is unexpectedly capable of delivering an improved anti-acne and anti-microbial benefit.

[0004] Background of the Invention

[0005] Acne, also known as Acne vulgaris, is a common skin condition that affects nearly all adolescents and adults at some point in their lives. It has been observed that acne usually occurs in areas rich in sebaceous glands like the face, neck and back. Bacteria Propionibacterium acnes (P. acnes) have also been implicated in occurrence of acne. It resides in the sebaceous glands. P. acnes uses sebum and by-product from surrounding skin tissue as sources of energy and nutrients, leading to acne or acne vulgaris.

[0006] Although many ways have been developed for treating acne, there is still a need to improve the efficacy of anti-acne. Therefore, the present inventors have developed a cosmetic composition comprising: (a) apricot oil; and (b) C?to C30 hydroxy aromatic carboxylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of total component (b) to total component (a) is from 10:1 to 100: 1 ; wherein said composition does not comprise guar hydroxypropyltrimonium chloride. It was surprisingly found that such composition is unexpectedly capable of providing an improved antiacne benefit.

[0007] Summary of the Invention

[0008] In a first aspect, the present invention is directed to a cosmetic composition comprising: (a) apricot oil; and (b) C?to C30 hydroxy aromatic carboxylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of total component (b) to total component (a) is from 10:1 to 100:1 ; wherein said composition does not comprise guar hydroxypropyltrimonium chloride.

[0009] In a second aspect, the present invention is directed to use of a cosmetic composition of the first aspect for providing benefit selected from anti-acne, anti-bacterial or a combination thereof. In a third aspect, the present invention is directed to a cosmetic composition of the first aspect for providing benefit selected from anti-acne, anti-bacterial or a combination thereof.

[0010] All other aspects of the present invention will more readily become apparent upon considering the detailed description and examples which follow.

[0011] Detailed Description of the Invention

[0012] Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and / or use may optionally be understood as modified by the word “about”.

[0013] All amounts are by weight of the composition, unless otherwise specified.

[0014] It should be noted that in specifying any range of values, any particular upper value can be associated with any particular lower value.

[0015] For the avoidance of doubt, the word “comprising” is intended to mean “including” but not necessarily “consisting of’ or “composed of’. In other words, the listed steps or options need not be exhaustive.

[0016] The disclosure of the invention as found herein is to be considered to cover all embodiments as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy.

[0017] Where a feature is disclosed with respect to a particular aspect of the invention (for example a composition of the invention), such disclosure is also to be considered to apply to any other aspect of the invention (for example a method of the invention) mutatis mutandis.

[0018] Typically, the apricot oil comprises or is apricot kernel oil. Preferably, the apricot oil is extracted from the kernels (seeds) of apricot (Prunus armeniaca) fruit, typically by separating the seeds of the apricot fruit and removing the hard woody coat. Preferably the apricot oil is extracted by cold pressing. Preferably, the amount of apricot oil is 0.00001 to 30% by weight of the composition. More preferably the amount of apricot oil is 0.0001 to 5%, even more preferably 0.001 to 1 % and still even more preferably 0.05 to 0.4% by weight of the composition.

[0019] The C? to C30 hydroxy aromatic carboxylic acid typically refers to the compound containing hydroxy group (other than the hydroxy group in carboxylic acid), aromatic group and carboxylic acid group; and having a total carbon number of 7 to 30. Preferably the C?to C30 hydroxy aromatic carboxylic acid comprises phenyl group. Preferably the C7 to C30 hydroxy aromatic carboxylic acid is C7 to C30 beta-hydroxy phenyl carboxylic acid. More preferably the C7 to C30 hydroxy aromatic carboxylic acid is salicylic acid.

[0020] Ester as used in the present invention typically refers to Ci to Ce alkyl ester thereof, preferably Ci to C4 alkyl ester.

[0021] Salt as used in the present invention comprises ammonium, calcium, magnesium, manganese, potassium, sodium, tetraalkylammonium, trialkylammonium, or a combination thereof, preferably the salt is potassium, sodium or a combination thereof.

[0022] Preferably, the amount of total C7to C30 hydroxy aromatic carboxylic acid, ester thereof, and salt thereof is 0.0001 to 5% by weight of the composition. More preferably the amount of total C7 to C30 hydroxy aromatic carboxylic acid, ester thereof, and salt thereof is 0.001 to 2.5%, even more preferably 0.02 to 1.5% and still even more preferably 0.1 to 0.8% by weight of the composition.

[0023] Preferably, the amount of total C7 to C30 beta-hydroxy phenyl carboxylic acid, ester thereof, and salt thereof is 0.0001 to 5% by weight of the composition. More preferably the amount of total C7 to C30 beta-hydroxy phenyl carboxylic acid, ester thereof, and salt thereof is 0.001 to 2.5%, even more preferably 0.02 to 1.5% and still even more preferably 0.1 to 0.8% by weight of the composition.

[0024] Preferably the weight ratio of total component (b) to total component (a) is from 10:1 to 100:1 , preferably 10:1 to 50:1 , more preferably from 10:1 to 20:1 , even more preferably from 10:1 to 15:1. Preferably the weight ratio of total C? to C30 beta-hydroxy phenyl carboxylic acid, ester thereof and salt thereof to total apricot oil is from 10:1 to 100:1 , preferably 10:1 to 50:1 , more preferably from 10:1 to 20: 1 , even more preferably from 10: 1 to 15: 1 .

[0025] Preferably, the present invention provides a cosmetic composition comprising: (a) apricot oil; and (b)salicylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of the total salicylic acid, ester thereof, and salt thereof to the apricot oil is from 10:1 to 100:1.

[0026] Preferably, the amount of total salicylic acid, ester thereof, and salt thereof is 0.0001 to 5% by weight of the composition. More preferably the amount of total salicylic acid, ester thereof, and salt thereof is 0.001 to 2.5%, even more preferably 0.02 to 1.5% and still even more preferably 0.1 to 0.8% by weight of the composition.

[0027] Preferably the weight ratio of total salicylic acid, ester thereof and salt thereof to total apricot oil is from 10:1 to 100:1 , preferably 10:1 to 50:1 , more preferably from 10:1 to 20:1 , even more preferably from 10: 1 to 15: 1 .

[0028] Preferably, the present invention provides a cosmetic composition comprising: (a) apricot kernel oil; and (b)salicylic acid, and / or salt thereof, wherein the weight ratio of the total salicylic acid and salt thereof to the apricot oil is from 10:1 to 100:1. Preferably, the salt of salicylic acid is sodium salicylate.

[0029] Preferably, the amount of apricot kernel oil is 0.00001 to 30% by weight of the composition. More preferably the amount of apricot kernel oil is 0.0001 to 5%, even more preferably 0.001 to 1% and still even more preferably 0.05 to 0.4% by weight of the composition.

[0030] Preferably, the amount of total salicylic acid, and salt thereof is 0.0001 to 5% by weight of the composition. More preferably the amount of total salicylic acid, and salt thereof is 0.001 to 2.5%, even more preferably 0.02 to 1.5% and still even more preferably 0.1 to 0.8% by weight of the composition.

[0031] Preferably the weight ratio of the total salicylic acid, and salt thereof to the apricot kernel oil is from 10: 1 to 100:1 , preferably from 10:1 to 50:1 , more preferably from 10:1 to 20:1 , even more preferably from 10: 1 to 15: 1 . The composition preferably comprises a cleansing surfactant. More than one cleansing surfactant may be included in the composition. The cleaning surfactant may be chosen from soap, non-soap anionic, cationic, non-ionic, amphoteric surfactant and mixtures thereof. The preferred surface-active compounds that can be used are soaps, non-soap anionic, non-ionic surfactant, amphoteric surfactant, or a mixture thereof.

[0032] Suitable non-soap anionic surfactants include linear alkylbenzene sulphonate, primary and secondary alkyl sulphates, particularly Cs to C15 primary alkyl sulphates; alkyl ether sulphates; olefin sulphonates; alkyl xylene sulphonates; dialkyl sulphosuccinates; fatty acid ester sulphonates; or a mixture thereof. Sodium salts are generally preferred.

[0033] Most preferred non-soap anionic surfactant are linear alkylbenzene sulphonate, particularly linear alkylbenzene sulphonates having an alkyl chain length of from Cs to C15. It is preferred if the level of linear alkylbenzene sulphonate is from 0 wt% to 30 wt%, more preferably from 1 wt% to 25 wt%, most preferably from 2 wt% to 15 wt%, by weight of the total composition.

[0034] Nonionic surfactants that may be used include the primary and secondary alcohol ethoxylates, especially the Cs to C20 aliphatic alcohols ethoxylated with an average of from 1 to 20 moles of ethylene oxide per mole of alcohol, and more especially the C10 to C15 primary and secondary aliphatic alcohols ethoxylated with an average of from 1 to 10 moles of ethylene oxide per mole of alcohol. Non ethoxylated nonionic surfactants include alkylpolyglycosides, glycerol monoethers, and polyhydroxyamides (glucamide). It is preferred if the level of non-ionic surfactant is from 0 wt% to 30 wt%, preferably from 1 wt% to 25 wt%, most preferably from 2 wt% to 15 wt%, by weight of the composition.

[0035] Suitable amphoteric surfactants preferably are betaine surfactants. Examples of suitable amphoteric surfactants include, but are not limited to, alkyl betaines, alkylamido betaines, alkyl sulfobetaines, alkyl sultaines and alkylamido sultaines; preferably, those having 8 to 18 carbons in the alkyl and acyl group. It is preferred that the amount of the amphoteric surfactant is 0 to 20 wt%, more preferably from 1 to 10 wt%, by weight of the composition.

[0036] It is also possible to include certain mono-alkyl cationic surfactants. Cationic surfactants that may be used include quaternary ammonium salts of the general formula R1R2R3R4N+X' wherein the R groups are long or short hydrocarbon chains, typically alkyl, hydroxyalkyl or ethoxylated alkyl groups, and X is a counter-ion (for example, compounds in which R1is a C8-C22 alkyl group, preferably a Cs-C or C12-C14 alkyl group, R2is a methyl group, and R3and R4, which may be the same or different, are methyl or hydroxyethyl groups); and cationic esters (for example, choline esters).

[0037] Water-soluble skin benefit agents may optionally be formulated into the compositions of the invention. A variety of water-soluble skin benefit agents can be used and the level can be from 0.1 to 50% but preferably from 1 to 30% by weight of the composition. These materials include, but are not limited to, polyhydroxy alcohols. Preferred water-soluble skin benefit agents are glycerin, sorbitol and polyethylene glycol.

[0038] Water-insoluble skin benefit agents may also be formulated into the compositions as conditioners and moisturizers. Examples include silicone oils; hydrocarbons such as liquid paraffins, petrolatum, microcrystalline wax, and mineral oil; and vegetable triglycerides such as sunflower seed and cottonseed oils.

[0039] Some compositions may include thickeners. These may be selected from cellulosics, natural gums and acrylic polymers, but are not limited to these thickening agent types. Among the cellulosics are sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose and combinations thereof. Suitable gums include xanthan, pectin, karaya, agar, alginate gums and combinations thereof. Among the acrylic thickeners are homopolymers and copolymers of acrylic and methacrylic acids including carbomers such as Carbopol 1382, Carbopol 982, llltrez, Aqua SF-1 and Aqua SF-2 available from the Lubrizol Corporation. Amounts of thickener may range from 0.01 to 3% by weight of compositions.

[0040] Preservatives can desirably be incorporated into the compositions of this invention to protect against the growth of potentially harmful microorganisms. Particularly preferred preservatives are phenoxyethanol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol. The preservatives should be selected having regard for the use of the composition and possible incompatabilities between the preservatives and other ingredients. Preservatives are preferably employed in amounts ranging from 0.01 % to 2% by weight of the composition.

[0041] A variety of other optional materials may be formulated into the compositions. These may include: antimicrobials such as 2-hydroxy-4,2’,4’-trichlorodiphenylether (triclosan), 2,6-dimethyl-4- hydroxychlorobenzene, and 3,4,4’-trichlorocarbanilide; scrub and exfoliating particles such as polyethylene and silica or alumina; cooling agents such as menthol; skin calming agents such as aloe vera; and colorants.

[0042] In addition, the compositions of the invention may further include 0.5 to 10% by weight of sequestering agents, such as tetra sodium ethylenediaminetetraacetate (EDTA), EHDP or mixtures; opacifiers and pearlizers such as ethylene glycol distearate, titanium dioxide or Lytron 621 (Styrene / Acrylate copolymer); all of which are useful in enhancing the appearance or properties of the product.

[0043] It is preferred that the composition comprises a cosmetically acceptable carrier. The cosmetically acceptable carrier is such that the composition can be prepared, e.g., as a shampoo, conditioner, body wash, hand wash or face wash product, cream, lotion, gel, powder, ointment, deodorant, hand sanitiser or a soap bar and the rest of the ingredients would vary accordingly. Preferably the composition comprises water in an amount of at least 5% by weight of the composition, more preferably at least 25%, even more preferably 40 to 90% and still even more preferably at least 60 to 85% by weight of the composition.

[0044] The composition of the present invention does not comprise guar hydroxypropyltrimonium chloride. Preferably, the composition does not comprise cationic guar polymer. More preferably, the composition does not comprise cationic galactomannans. Even more preferably, the composition does not comprise cationic polymer. Non-liming examples of cationic polymer can include cationic galactomannans, cationic cellulose.

[0045] Preferably, the composition has a viscosity of at least 5 mPa s, more preferably in the range 8 to 10000 mPa s, even more preferably 10 to 1000 mPa s, and most preferably 20 to 200 mPa s, when measured at 20 degrees C at a relatively high shear rate of about 20 s’1. Preferably, the composition is in the form of fluid.

[0046] The cosmetic composition refers to a composition suitable for topical application to human skin, preferably is a rinse-off product. The term "rinse-off" as used with reference to compositions herein means a composition that is applied to or rubbed on the skin, and then washed off. The term "skin" as used herein includes the skin on the face (except eye lids and lips), neck, chest, abdomen, back, arms, under arms, hands, and legs. Preferably “skin” means includes the skin on the face (except eye lids and lips) and under arms, more preferably skin means skin on the face other than lips and eyelids. The present invention also provides use of a cosmetic composition of the first aspect for providing benefit selected from anti-acne, anti-bacterial or a combination thereof.

[0047] The present invention also provides use of a cosmetic composition of the first aspect in a method for providing benefit selected from anti-acne, anti-bacterial or a combination thereof, the method comprising topical application of apricot oil or a cosmetic composition of the first aspect.

[0048] Preferably the use is non-therapeutic. Preferably the method is non-therapeutic. The term non- therapeutic typically means for cosmetic purposes and not curative or therapeutic purposes.

[0049] The following examples are provided to facilitate an understanding of the invention. The examples are not intended to limit the scope of the claims.

[0050] Examples

[0051] This example demonstrates the improved antibacterial effects.

[0052] Table 1

[0053] ‘Significantly better than any of A, B, C, D and E (p<0.05) a: Seatons Apricot Kernel Oil, procured from Croda.

[0054] Zone of Inhibition (ZOI) of different samples toward Propionibacterium acne (P. acnes) was tested. Samples were prepared according to Table 1 . 20 pL of each sample or control sample (aseptic distilled water) were dipped onto identical filter papers and all of these filter papers were dried. Cultures of Propionibacterium acnes were washed and diluted by PBS to provide a suspension with concentration of (1-10)x106cfu / mL. The suspension was evenly smeared on a nutrient agar culture medium plate by aseptic cotton swab. The dried filter papers with samples were closely applied onto the plated with sufficient distances. The plate was covered and cultured at 37°C for 16 to18 hours. The samples diffuse into the agar are assayed for an ability to produce a zone of inhibition. The diameters of ZOI for different samples were recorded in Table 1 . The bigger the ZOI is, the better anti-acne efficiency the sample provides. It is evident from Table 1 that Samples 1 and 2 provided significantly better antibacterial efficiency that any of sample A, B, C, D and E. It was surprisingly found that it is capable of providing significantly improved antibacterial effects when combining apricot kernel oil and salicylic acid in a weight ratio according to the present invention. Example 2

[0055] This example demonstrates a cometic composition of the present invention.

[0056] A skin cleansing composition was prepared according to Table 2 by following standard procedure.

[0057] Table 2

Claims

Claims1 . A cosmetic composition comprising:(a) apricot oil; and(b) Cyto C30 hydroxy aromatic carboxylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of total component (b) to total component (a) is from 10:1 to 100:1 ; wherein said composition does not comprise guar hydroxypropyltrimonium chloride.

2. The composition according to claim 1 wherein the apricot oil is apricot kernel oil.

3. The composition according to claim 1 or 2 wherein the amount of apricot oil is 0.00001 to 30% by weight of the composition, preferably the amount of apricot oil is 0.001 to 1 % by weight of the composition.

4. The composition according to any one of the preceding claims wherein the Cyto C30 hydroxy aromatic carboxylic acid is Cyto C30 beta-hydroxy phenyl carboxylic acid, preferably the Cy to C30 hydroxy aromatic carboxylic acid is salicylic acid.

5. The composition according to any one of the preceding claims wherein the amount of total Cy to C30 hydroxy aromatic carboxylic acid, ester thereof, and salt thereof is 0.0001 to 5% by weight of the composition, preferably the amount of apricot oil is 0.02 to 1.5% by weight of the composition.

6. The composition according to any one of the preceding claims wherein the weight ratio of total component (b) to total component (a) is from 10:1 to 50:1 , preferably from 10:1 to 20:1 , more preferably from 10: 1 to 15: 1 .

7. A cosmetic composition comprising: (a) apricot oil; and (b)salicylic acid, ester thereof, and / or salt thereof, wherein the weight ratio of the total salicylic acid, ester thereof, and salt thereof to the apricot oil is from 10:1 to 100:1.

8. The composition according to claim 7 wherein the amount of total salicylic acid, ester thereof, and salt thereof is 0.0001 to 5% by weight of the composition, preferably 0.1 to 0.8% by weight of the composition.

9. The composition according to claim 7 or 8 wherein the weight ratio of the total salicylic acid, ester thereof and salt thereof to the apricot oil is 10: 1 to 50: 1 , preferably from 10:1 to 20: 1 , more preferably from 10: 1 to 15: 1.

10. A cosmetic composition comprising: (a) apricot kernel oil; and (b)salicylic acid, and / or salt thereof, wherein the weight ratio of the total salicylic acid and salt thereof to the apricot oil is from 10:1 to 100:1.

11. The composition according to claim 10 wherein the amount of the apricot kernel oil is 0.00001 to 10% by weight of the composition, preferably 0.05 to 0.4% by weight of the composition.

12. The composition according to claim 10 or 11 wherein the amount of total salicylic acid, and salt thereof is 0.001 to 2.5%, preferably 0.02 to 1.5% by weight of the composition.

13. The composition according to any one of the preceding claims 10 to 12 wherein the weight ratio of the total salicylic acid and salt thereof to the apricot kernel oil is 10:1 to 50:1 , preferably from 10:1 to 20:1 , more preferably from 10:1 to 15:1.

14. Use of a cosmetic composition according to any one of the preceding claims for providing benefit selected from anti-acne, anti-bacterial or a combination thereof.

15. A cosmetic composition according to any one of the preceding claims for providing benefit selected from anti-acne, anti-bacterial or a combination thereof.

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