Method and a device for applying an analyte to a detection element

By controlling solvent evaporation through a membrane with differential gaseous saturation, the coffee ring effect is suppressed, ensuring uniform analyte distribution and enhancing the accuracy and reproducibility of spectroscopic measurements on small analysis chips.

WO2026125564A1 Publication Date: 2026-06-18INVISIBLE LIGHT LABS GMBH
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
INVISIBLE LIGHT LABS GMBH
Filing Date
2025-12-11
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

The coffee ring effect in drop casting methods for applying analytes on small analysis chips leads to uneven distribution and non-uniform coatings, causing inaccuracies and reduced reproducibility in spectroscopic measurements, particularly in infrared spectroscopy.

⚗Method used

A method and device using a membrane with a deposition section that allows solvent evaporation through a gaseous atmosphere with controlled solvent saturation, where a higher saturation is maintained near the deposition surface and a lower saturation is maintained near the drying surface, preventing solvent flow and ensuring homogeneous analyte distribution.

🎯Benefits of technology

This approach suppresses the coffee ring effect, resulting in uniform analyte distribution and improved sensitivity, reproducibility, and accuracy of spectroscopic measurements.

✦ Generated by Eureka AI based on patent content.

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Abstract

Method for applying an analyte (2) to a detection element (3), wherein the detection element (3) comprises a membrane (4) with a deposition surface (5) and a drying surface (8) opposite of the deposition surface (5), wherein the membrane (4) comprises a deposition section (9), with the steps: - Casting a droplet (6) onto the deposition surface (5), wherein the droplet (6) comprises a solvent (7) in a liquid state and an analyte (2), wherein the analyte (2) is dissolved and / or dispersed in the solvent (7), wherein the deposition section (9) is permeable to the solvent (7) at least in a gaseous state, wherein the deposition section is preferably impermeable to the solvent (7) in the liquid state; - Providing a first gaseous atmosphere (13) adjacent to the deposition surface (5) with a first solvent saturation; - Providing a second gaseous atmosphere (11) adjacent to the drying surface (8) with a second solvent saturation, wherein the second solvent saturation is lower than the first solvent saturation; and - Evaporating the solvent (7) such that the analyte (4) is applied to the detection element (3).
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