Transient oil-in-simethicone emulsion

A transient oil-in-simethicone emulsion with 50% to 80% simethicone content, stabilized by fumed silica, addresses dissolution interference and phase stability issues, ensuring uniformity and bioavailability of active ingredients like loperamide, suitable for gastrointestinal treatments.

WO2026127819A1 Publication Date: 2026-06-18NOVEX SCI PTE LTD
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
NOVEX SCI PTE LTD
Filing Date
2025-11-12
Publication Date
2026-06-18

AI Technical Summary

⚠Technical Problem

Existing formulations of simethicone with other active ingredients, such as loperamide, face issues with dissolution rate interference and phase stability, particularly in oil-in-water emulsions, leading to inconsistent bioavailability and formulation complexity.

⚗Method used

Development of a transient oil-in-simethicone emulsion with a specific range of simethicone content (50% to 80% by weight) that separates into phases after encapsulation, using fumed silica for stabilization without traditional surfactants, ensuring content uniformity and bioavailability of active ingredients.

🎯Benefits of technology

The transient emulsion maintains stability during preparation and filling, ensuring uniform distribution and avoids phase separation, enhancing the bioavailability of active ingredients like loperamide, while allowing for a smaller, bioequivalent capsule size compared to commercial products.

✦ Generated by Eureka AI based on patent content.

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Abstract

A transient oil-in-simethicone emulsion for oral administration wherein 5 simethicone is present from 50% to 80% by weight of the emulsion. Also described is the process for the preparation of the transient oil-in-simethicone emulsion and capsule dosage form.
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