Companion diagnostic methods of administering PDE4 inhibitors

Abstract

Personalized methods of determining a reference PDE4 Inhibitor Resistance Metric for treating a future patient in need of treatment, and methods of treating a subject with an inflammatory bowel disease are provided.

Description

[0001] Atorney Docket No. 4603.0133-132WO

[0002] COMPANION DIAGNOSTIC METHODS OF ADMINISTERING PDE4 INHIBITORS

[0003] This application claims benefit U.S. Application No. 63 / 733,390, filed December 12, 2024, which is hereby incorporated by reference in its entirety.

[0004] FIELD

[0005] The present disclosure generally relates to the field of precision medicine and personalized methods of administering PDE4 inhibitors.

[0006] BACKGROUND

[0007] A patient and doctor, confronted with a chronic disease such as inflammatory bowel disease (IBD), ideally has several treatment options to consider, while desiring to minimize the time to a successful outcome. It would be helpful to assist the patient to determine, in advance, if a particular therapy, such as a PDE4 inhibitor would be likely to deliver an effective treatment outcome, or if alternatively, another treatment modality would be more likely to deliver relief.

[0008] Prior efforts have been made to predict whether a patient would likely respond to treatment based on a patients’ unique genetic profile. In a prior published method, Pavlidis et al. (2019), PLoS Comput Biol 15(4) :e 1006951 , the authors noted that Crohn’s disease and ulcerative colitis exhibit heterogeneity and is characterized by variable clinic responses to therapeutic interventions. To address this challenge, the authors propose a Molecular Activity Disease Score (I MDS) based on 103 gene signatures, 58 of which were found to be overlapping in UC and CD patients, which are based on numerous genes within each signature. In summary, the MDS score proposed by Pavlidis et al. relies upon over 100 markers.

[0009] While beneficial for academic and discovery purposes, it is less useful in a managed-care clinical setting to assist patients, at least because it requires the measurement of a large number of markers, and thus a high expense to implement the diagnostic test. This expense is tougher to justify when dealing with chronic indications like IBD that are conventionally deemed non-life-threatening, and in which it is easier to justify having a patient blindly try a medication rather than spending a large amount of resources to get a better understanding of that medication’s potential effectiveness. This, however, comes at the expense of the patient potentially having to undergo continued suffering until the proper medication or treatment modality is found under a traditional trial and error approach.

[0010] Thus, there remains a need to accurately identify potential patients for therapy based on techniques requiring the measurement of fewer markers, while maintaining or even increasing the accuracy of the prior techniques.

[0011] SUMMARY

[0012] The subject disclosure addresses these needs and provides personalized methods for ascertaining with greater certainty whether a patient suffering from a disease or condition (e.g., an inflammatory disease or IBD, such as ulcerative colitis or Crohn’s disease) would be a responder or non-responder to therapy (e.g., PDE4 inhibitors). In certain exemplary embodiments, such methods can achieve comparable or even higher sensitivity and specificity with less than 10 markers, as compared to prior techniques requiring upwards of 130 markers. One aspect of the subject disclosure provides a method for treating a subject with an inflammatory disease such as an inflammatory bowel disease (e.g., ulcerative colitis or Crohn’s disease). In one exemplary embodiment, the method includes obtaining a biological sample from the subject with inflammatory bowel disease, measuring gene expression levels of one or more genes from group consisting of: DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, IL1B, CXCL8, S100A12, SELE, ITPRIP, PRPS1, AVPI1, NOS2, 0DC1, IL6, NFKBIZ, IGHG1, and CALR in the biological sample; applying an algorithm to the measured gene expression levels to generate a PDE4 Inhibitor Resistance Metric; classifying the human subject with inflammatory bowel disease as a likely responder or non-responder to a PDE4 inhibitor based on a comparison of the PDE4 Inhibitor Resistance Metric with a cut-off value obtained from a pool of research subjects with inflammatory bowel disease; and administering a PDE4 inhibitor drug treatment to the subject if identified as a responder (e.g., the PDE4 inhibitor is administered to the subject if the PDE4 Inhibitor Resistance Metric is below the cut-off value). In certain embodiments, gene expression levels of any subset of two to up to this entire gene set of these 21 genes can be measured.

[0013] For example, in an exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, five or more, or all six genes selected from the group consisting of: DU0XA2, LUCAT1, CXCR1, CCL4, MMP1 and MMP2 is measured. In another embodiment, the expression level of one or more, two or more, three or more, four or more, five or more, or all six genes selected from the group consisting of: CSF3, DU0XA2, HCAR3, CCL4, IL1B and CXCL8 is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, CXCR1, S100A12, LUCAT1 and SELE is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CCL4, ITPRIP, PRPS1, AVPI1 and NOS2 is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CCL4, ITPRIP, PRPS1, AVPI1 and NOS2 is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, HCAR3, CXCR1, LU CAT 1 and SELE is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, HCAR3, CCL4, S100A12 and SELE is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: 0DC1, IL6, ITPRIP, CXCR1 and NOS2 is measured. In another exemplary embodiment, the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: 0DC1, NFKBIZ, CCL4, IGHG1, and CALR is measured.

[0014] Another aspect of the subject disclosure provides a method of determining a PDE4 Inhibitor Resistance Metric and cut-off value for a future subject in need of treatment for an inflammatory bowel disease (e.g., ulcerative colitis or Crohn’s disease). In an exemplary embodiment, the method includes obtaining a data set from a set of reference patients, the data set including expression level data for genes from a sample domain of genes for each reference patient, and an indication as to whether each reference patient was a documented responder or non-responder to a previously -initiated therapeutic intervention; applying machine learning to obtain an algorithm to iteratively determine from the sample domain of genes a ranking and a weight factor for

[0015] 2

[0016] 4935-6038-7201 , v. 2 each gene in the sample domain to most accurately predict from the expression level data whether a reference patient would be classified as a responder or a non-responder, as compared to the documented responder or nonresponder status in the curated data set, and obtaining a top set of genes containing the highest-ranked genes, wherein the number of genes in the top set of genes is less than the number of genes in the sample domain; obtaining a PDE4 Inhibitor Resistance Metric for each reference patient based on the expression level data and the weight factor for each gene, and a cut-off value to separate the PDE4 Inhibitor Resistance Metric for responding patients and non-responding reference patients; determining, in an iterative manner, from the top set of genes which individual combination of x number of genes, from all possible permutations of x number amongst the top set of genes, most accurately predicts from the expression level data whether a reference patient would be classified as a responder or a non-responder, as compared to the documented responder or non- responder status in the curated data set to obtain a final gene set, wherein x is less than the number of genes in the top gene set; and providing the final gene set to obtain a personalized PDE4 Inhibitor Resistance Metric for the future subject in need of treatment for inflammatory bowel disease based on measured expression levels for the future subject and the weight factor for each gene in the final gene set.

[0017] Another aspect of the subject disclosure provides a method for treating a subject with inflammatory bowel disease, the method including obtaining a data set from a set of reference patients, the data set including expression level data for genes from a sample domain of genes for each reference patient, and an indication as to whether each reference patient was a documented responder or non-responder to a previously -initiated therapeutic intervention; applying machine learning to obtain an algorithm (e.g., a multinomial logistic algorithm) to iteratively determine from the sample domain of genes a ranking and a weight factor each gene in the sample domain to most accurately predict from the expression level data whether a reference patient would be classified as a responder or a non-responder, as compared to the documented responder or non-responder status in the curated data set, and obtaining a top set of genes (for example, about 10 to about 30 genes) containing the highest ranked genes, wherein the number of genes in the top set of genes is less than the number of genes in the sample domain; obtaining a PDE4 Inhibitor Resistance Metric for each reference patient based on the expression level data and the weight factor for each gene, and a cut-off value to separate the PDE4 Inhibitor Resistance Metric for responding patients and non-responding reference patients; determining, in an iterative manner, from the top set of genes which individual combination of x number of genes, from all possible permutations of x number amongst the top set of genes, most accurately predicts from the expression level data whether a reference patient would be classified as a responder or a non-responder, as compared to the documented responder or non-responder status in the curated data set to obtain a final gene set (e.g., about 4 to about 7 genes), wherein x is less than the number of genes in the top gene set; providing the final gene set to obtain a personalized PDE4 Inhibitor Resistance Metric for a future patient in need of treatment for inflammatory bowel disease based on measured expression levels for the future patient and the weight factor for each gene in the final gene set; obtaining a biological sample from the subject with inflammatory bowel disease; measuring gene expression levels of each gene in the final gene set; applying the weight factor to the measured gene expression levels to generate a personalized PDE4 Inhibitor Resistance Metric for the subject with inflammatory bowel disease; classifying the human subject with ulcerative colitis disease as a likely responder or non-responder to a PDE4 inhibitor if the personalized PDE4 Inhibitor Resistance Metric is below the cut-off value; and administering a PDE4 inhibitor drug treatment to the subject if identified as a likely responder.

[0018] 3

[0019] 4935-6038-7201 , v. 2 In one exemplary embodiment, top set of genes includes one or more of, AVPI1, CALR, CCL4, CSF3,

[0020] CXCL8, CXCR1, DU0XA2, HCAR3, IGHG1, IL1B, IL6, ITPRIP, LUCAT1, MMP1, MMP2, NFKBIZ, NOS2,

[0021] ODC1, PRPS1, S100A12, and SELE and gene expression levels are measured via a PCR assay or gene expression assay.

[0022] BRIEF DESCRIPTION OF FIGURES

[0023] For a more complete understanding of the invention, reference is now made to the Detailed Description and Examples in conjunction with the accompanying figures.

[0024] FIG. 1 and FIG. 2 depict an expression correlation across selected markers of interest depicting the correlation of expression in the pediatric RNAseq dataset (FIG. 1) and the adult microarray (FIG. 2) with PDE4B expression.

[0025] FIG. 3 is a schematic depiction of the multinomial logistic regression modelling of a sample domain of genes, as described in Example 3.

[0026] FIG. 4 depicts the results of a Prior Published Method (PPM) as originally published.

[0027] FIG. 5 depicts the results of the PPM, as replicated in house.

[0028] FIG. 6 depicts the results depicts the results as simulated based on the combinatorial approach with the gene sample domain of Example 1 based on only 5 gene signatures.

[0029] FIG. 7 depicts the results of the PPM in the pediatric RNAseq data set GSE 109142 based on 130 gene signatures.

[0030] FIG. 8 depicts the results of the combinatorial approach with the gene sample domain of Example 1 based on only 5 gene signatures.

[0031] FIG. 9 depicts the results of a GSVA Validation of Biomarkers as described in Example 8.

[0032] DETAILED DESCRIPTION

[0033] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

[0034] For the sake of brevity, all publications, including patent applications, patents, and other citations mentioned herein, are incorporated by reference in their entirety to the same extent as if each individual publication, patent or patent application was specifically and individually incorporated by reference. Citation of any such publication, however, shall not be construed as an admission that it is prior art to the present invention.

[0035] TERMS AND DEFINITIONS

[0036] Unless defined otherwise, all terms of art, notations and other technical and scientific terms or terminology used herein are intended to have the same meaning as is commonly understood by one of ordinary skill in the art to which the claimed subject matter pertains. In some cases, terms are defined herein for clarity or ready reference so that the present disclosure may be more readily understood, and the inclusion of such

[0037] 4

[0038] 4935-6038-7201 , v. 2 definitions herein should not necessarily be construed to represent a substantial difference over what is generally understood in the art.

[0039] As used herein, the terms “a,” “an,” and “the” are to be understood as meaning both singular and plural, unless explicitly stated otherwise. Thus, “a,” “an,” and “the” (and grammatical variations thereof where appropriate) refer to one or more. For example, the term “a capsule” includes a plurality of capsules, and mixtures thereof. The presence of broadening words and phrases such as “one or more,” “at least,” “but not limited to” or other like phrases in some instances shall not be read to mean that the narrower case is intended or required in instances where such broadening phrases may be absent. As will become apparent to one of ordinary skill in the art after reading this document, the illustrated embodiments and their various alternatives may be implemented without confinement to the illustrated examples.

[0040] A group of items linked with the conjunction “and” should not be read as requiring that each and every one of those items be present in the grouping, but rather should be read as “and / or” unless expressly stated otherwise. Similarly, a group of items linked with the conjunction “or” should not be read as requiring mutual exclusivity among that group, but rather should also be read as “and / or” unless expressly stated otherwise. Furthermore, although items, elements or components of the invention may be described or claimed in the singular, the plural is contemplated to be within the scope thereof, unless limitation to the singular is explicitly stated.

[0041] Throughout this application, various embodiments may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the disclosure. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range.

[0042] Moreover, any concentration range, percentage range, ratio range or integer range is to be understood to include the value of any integer within the recited range and, when appropriate, fractions thereof (such as one tenth and one hundredth of an integer), unless otherwise indicated.

[0043] As used herein, the term “about” or “approximately” means within an acceptable range for a particular value as determined by one skilled in the art and may depend in part on how the value is measured or determined, e.g., the limitations of the measurement system or technique. For example, “about” can mean a range of up to 20%, up to 10%, up to 5%, or up to 1% or less on either side of a given value. Thus, where a numerical limitation is used, unless indicated otherwise by the context, “about” means that the numerical value can vary by ±20%, and remain within the scope of the disclosed embodiments, and can be further narrowed, if so specified, to ±10%, 5%, or ±l%.

[0044] The terms “comprising” and “including” are used herein in their open, non-limiting sense. Other terms and phrases used in this document, and variations thereof, unless otherwise expressly stated, should be construed as open ended, as opposed to limiting. Thus, the term “example” is used to provide exemplary instances of the item in discussion, not an exhaustive or limiting list thereof. Similarly, adjectives such as

[0045] 5

[0046] 4935-6038-7201 , v. 2 “conventional,” “traditional,” “normal,” or “known” and terms of similar meaning should not be constmed as limiting the item described to a given time period or to an item available as of a given time, but they should be read to encompass conventional, traditional, or normal technologies that may be available or known now or at any time in the future. Likewise, where this document refers to technologies that would be apparent or known to one of ordinary skill in the art, such technologies encompass those apparent or known to the skilled artisan now or at any time in the future.

[0047] “Administering” refers to the physical introduction of a composition comprising a therapeutic agent, such as a PDE4 Inhibitor to a subject, using any of the various methods and delivery systems known to those skilled in the art. Preferred routes of administration for antibodies (Abs) of the invention include intravenous, intramuscular, subcutaneous, intraperitoneal, spinal or other parenteral routes of administration, for example by injection or infusion. The phrase “parenteral administration” as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intraarterial, intrathecal, intralymphatic, intralesional, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal, epidural and intrastemal injection and infusion, as well as in vivo electroporation. Alternatively, an Ab of the disclosure can be administered via a non-parenteral route, such as a topical, epidermal or mucosal route of administration, for example, intranasally, orally, vaginally, rectally, sublingually or topically. Administering can also be performed, for example, once, a plurality of times, and / or over one or more extended periods. In embodiments, administering refers to oral administration in the case of TQ compositions and parental administration in the case of antibodies used herein.

[0048] As used herein, the term "PDE4 Inhibitor Resistance Metric" refers to a numerical value generated by applying an algorithm to measured gene expression levels from a biological sample, wherein the algorithm incorporates a weight factor for each gene in a defined gene set. The PDE4 Inhibitor Resistance Metric may be used to classify a subject as a likely responder or non-responder to PDE4 inhibitor therapy by comparing the metric to a cut-off value. In some aspects, the cut-off value is derived from a pool of reference patients with documented responder or non-responder status to a previously -initiated PDE4 inhibitor therapeutic intervention. A subject may be classified as a likely responder when the PDE4 Inhibitor Resistance Metric is below (or above, depending on context) the cut-off value, and as a likely non-responder when the PDE4 Inhibitor Resistance Metric is at or above (or below, depending on context) the cut-off value.

[0049] The terms “individual,” “subject,” “participant,” and “patient” are used interchangeably herein and can be a vertebrate, in particular, a mammal, more particularly, a primate (including non-human primates and humans) and include a laboratory animal in the context of a clinical or pre-clinical trial or screening or activity experiment. Thus, as can be readily understood by one of ordinary skill in the art, the formulations of the present invention are particularly suited to administration to any vertebrate, particularly a mammal, and more particularly, a human.

[0050] As used in the present disclosure, the term “effective amount” is interchangeable with “therapeutically effective amount” and, unless the context dictates otherwise, generally means an amount or dose of a PDE4 Inhibitor effective in treating the particular disease, condition, or disorder disclosed herein, and thus “treating” includes producing a desired preventative, inhibitory, relieving, or ameliorative effect. In methods of treatment

[0051] 6

[0052] 4935-6038-7201 , v. 2 according to the invention, “an effective amount” of any one of the presently described formulations is administered to a subject (e.g., a mammal). The “effective amount” will vary, depending on numerous factors, such as the compound, the disease (and its severity), the treatment desired, and age and weight of the subject, and can be determined by persons of ordinary skill in the art based on the circumstance.

[0053] A “therapeutically effective amount” or “therapeutically effective dosage” of a drug or therapeutic agent, such as a PDE4 Inhibitor composition of the disclosure, is any amount of the dmg that, when used alone or in combination with another therapeutic agent, protects a subject against the onset of a disease or promotes disease regression evidenced by a decrease in severity of disease symptoms, an increase in frequency and duration of disease symptom-free periods, or a prevention of impairment or disability due to the disease affliction. The ability of a therapeutic agent to promote disease regression can be evaluated using a variety of methods known to the skilled practitioner, such as in human subjects during clinical trials, in animal model systems predictive of efficacy in humans, or by assaying the activity of the agent in in vitro assays.

[0054] The term “carrier” refers to an adjuvant, vehicle, or excipients, with which the compound is administered. In certain embodiments, the carrier is a solid carrier. Suitable pharmaceutical carriers include those described in Remington: The Science and Practice of Pharmacy, 23rd Edition (2020).

[0055] The term “formulation,” as used herein, is the form in which the dose is to be administered to the subject or patient.

[0056] The term “pharmaceutically acceptable,” as used in connection with formulations of the subject disclosure, refers to molecular entities and other ingredients of such formulations that are physiologically tolerable and do not typically produce untoward reactions when administered to an animal (e.g., human) according to their intended mode of administration (i.e., oral).

[0057] A “pharmaceutically acceptable excipient” refers to a substance that is non-toxic, biologically tolerable, and otherwise biologically suitable for administration to a subject, such as an inert substance, added to a pharmacological formulation or otherwise used as a vehicle, carrier, or diluents to facilitate administration of an agent and that is compatible therewith. Suitable pharmaceutical carriers include those described in Remington: The Science and Practice of Pharmacy, 23rd Ed. (2020).

[0058] As used herein, the term “inert” refers to any inactive ingredient of a described formulation. The definition of “inactive ingredient” as used herein follows that of the U.S. Food and Dmg Administration, as defined in 21 C.F.R. 201.3 (b)(8), which is any component of a drug product other than the active ingredient.

[0059] As used herein, “suitable for oral administration” refers to a sterile, pharmaceutical product, such as a product produced under good manufacturing practices (GMP), as understood in the art, suitable for administration to a subject (e.g., a human subject). As used herein, products suitable for oral administration include liquid dosage forms or formulations. Such products can also be a solid dosage form or a solid dosage formulation, which as used herein, includes formulation (such as capsules and soft gel capsules) that comprise an inner solution, such as black seed oil (BSO).

[0060] As used herein, the term “disorder” is used interchangeably with “disease” or “condition.” For example, a pulmonary disorder also means a pulmonary disease or a pulmonary condition, including neoplasms, cancers, carcinomas, tumors, and malignancies. Likewise, an extra-pulmonary disorder also means an

[0061] 7

[0062] 4935-6038-7201 , v. 2 extra-pulmonary disease or extra-pulmonary condition, including neoplasms, cancers, carcinomas, tumors, and malignancies.

[0063] The terms “treat,” “treating,” and “treatment” cover therapeutic methods directed to a disease-state in a subject and include: (i) preventing the disease-state from occurring, in particular, when the subject is predisposed to the disease-state but has not yet been diagnosed as having it; (ii) inhibiting the disease-state, e.g., arresting its development (progression) or delaying its onset; and (iii) relieving the disease-state, e.g., causing regression of the disease state until a desired endpoint is reached. These terms also include ameliorating a symptom of a disease (e.g., reducing the pain, discomfort, or deficit), wherein such amelioration may be directly affecting the disease (e.g., affecting the disease’s cause, transmission, or expression) or not directly affecting the disease.

[0064] As used herein, the term "machine learning" refers to computational methods and algorithms that enable a system to iteratively learn from data, identify patterns, and make predictions or classifications without being explicitly programmed for each specific outcome. Machine learning may encompass supervised learning techniques, such as regression and classification algorithms, as well as unsupervised learning approaches. In some aspects, machine learning may include methods such as multinomial logistic regression, which can be used to determine rankings, weight factors, or other parameters from training data sets to predict outcomes for new data inputs.

[0065] As used herein, the term "top set of genes" refers to a subset of genes selected from a sample domain of genes based on their ranking and predictive value as determined through machine learning analysis. The top set of genes may include genes that have been identified as having the highest-ranked weight factors for predicting whether a subject would be classified as a responder or non-responder to a therapeutic intervention. In some aspects, the selection of genes for inclusion in the top set of genes incorporates an analysis of cocorrelation among the genes, wherein co-correlation refers to the tendency of expression levels of the genes to increase or decrease in concert across the analysis domain. Without intending to be bound by theory, genes that display co-correlated expression patterns may share a common involvement in one or more biological functions or pathways relevant to the disease state or treatment response being evaluated. Accordingly, the top set of genes may be refined through iterative analysis to identify genes whose expression is coordinately regulated and that demonstrate a propensity to act in concert together across the entire analysis domain, such as across multiple patient samples, tissue types, or data sets. A ranking methodology that is based exclusively on simple gross numerical contribution of individual genes alone, without analysis of their likely co-correlation with other genes in the set, is likely to yield a poor predictive ranking that fails to capture the coordinated biological activity underlying treatment response.

[0066] Reference will now be made to the embodiments of the present invention, examples of which are illustrated by and described in conjunction with the accompanying examples. While certain embodiments are described herein, it is understood that the described embodiments are not intended to limit the scope of the invention. On the contrary, the present disclosure is intended to cover alternatives, modifications, and equivalents that can be included within the invention as defined by the presently disclosed embodiments.

[0067] 8

[0068] 4935-6038-7201 , v. 2 CURATED DATA SETS

[0069] The publicly available GSE109142 dataset relates to mucosal transcriptome of rectal biopsies in treatment-naive, pediatric ulcerative colitis patients with expression profiling by high throughput sequencing using recal mucosal biopsies. RNA sequencing was performed to generate transcriptomic profiles linked to pathogenesis, severity, and treatment response to corticosteroid-induced remission, as described in Haberman Y, Kams R, Dexheimer PJ, Schirmer M et al. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. See Nat Commun 2019 Jan 3; 10(l):38. PMID: 30604764, hereby incorporated by reference in its entirety.

[0070] The publicly available GSE16879 dataset provides a curated mucosal expression profile in patients with inflammatory bowel disease before and after their first infliximab treatment. Microarrays were used to identify mucosal gene signatures predictive of response to infliximab (IFX) in patients with inflammatory bowel disease (IBD) and to gain more insight into the pathogenesis of IBD. More particularly, Mucosal biopsies were obtained at endoscopy in actively inflamed mucosa from 61 IBD patients (24 ulcerative colitis (UC), 19 Crohn’s colitis (CDc) and 18 Crohn’s ileitis (CDi)), refractory to corticosteroids and / or immunosuppression, before and 4-6 weeks after (except for 1 CDc patient) their first infliximab infusion and in normal mucosa from 12 control patients (6 colon and 6 ileum). The patients were classified for response to infliximab based on endoscopic and histologic findings at 4-6 weeks after first infliximab treatment. Total RNA was isolated from intestinal mucosal biopsies, labelled and hybridized to Affymetrix Human Genome U133 Plus 2.0 Arrays. See Arijs I, De Hertogh G, Lemaire K, Quintens R et al. Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One 2009 Nov 24;4(ll):e7984. PMID: 19956723, hereby incorporated by reference.

[0071] The publicly available GSE150961 dataset provides a differential expression analysis between baseline rectal RNAseq biopsies of 21 patients who progressed to colectomy, and 310 who did not. Rectal gene expression of pediatric patients with ulcerative colitis at diagnosis and at one year follow-up was also reported.

[0072] The publicly available GSE83687 dataset provides IBD gene expression profiling in which surgical specimens from 134 patients undergoing bowel resection for inflammatory bowel disease (IBD) and non IBD controls at Mount Sinai Medical Center were collected as the source of tissue. Control samples (CLs) were harvested from normal non inflamed bowel located more than 10 cm away from the tumor from patients undergoing bowel resection for sporadic colon cancer. Ulcerative colitis (UC) and Crohn’s (CD) patient samples were all isolated from areas containing moderate to severe inflammation. Patients with UC and patients with CD shared common medications including corticosteroids, infliximab, azathioprine, and mesalamine.

[0073] The publicly available GSE166925 dataset provides expression profiling by high throughput sequencing of inflamed and non-inflamed resected intestinal tissue from IBD patients. Details regarding the identification of gene coexpression signatures, and further bulk RNA sequencing data availability can be found in Friedrich et al., “IL-l-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies,” Nat Med. (2021) Nov;27(ll): 1970-1981, doi: 10.1038 / s41591-021-01520-5. Epub 2021 Oct 21, which is hereby incorporated by reference in its entirety.

[0074] 9

[0075] 4935-6038-7201 , v. 2 The publicly available GSE193677 dataset provides whole transcriptome data generated in biopsy specimens sampled from a large cohort of adult IBD and control subjects in their attempt to provide molecular measures of disease activity in the gut and molecular mechanisms and biomarkers underlying IBD pathology. Further details regarding this dataset can be found in Argmann et al., Biopsy and blood-based molecular biomarker of inflammation in IBD. Gut 2023 Jul;72(7): 1271-1287. PMID: 36109152, which is hereby incorporated by reference in its entirety.

[0076] The publicly available GSE111889 dataset provides measurements from over 100 subjects, sampled biweekly over up to a year in both adult and pediatric patients with IBD (Crohn’s disease and ulcerative colitis), along with non-IBD controls. Data types include fecal metagenomes, metatranscriptomes, metabolomes, and proteomes, as well as host genetics, intestinal biopsy transcriptomes, epigenetics, and 16S amplicon profiles. Subjects’ medical histories and demographics are collected at baseline and medication, diet, and disease activity profiled longitudinally. Further details regarding this dataset can be found in the Inflammatory Bowel Disease Multi’omics Database [www<dot>ibdmdb<dot>com] and in Arze et al., Multi’omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature 2019 May;569(7758):655-662. PMID: 31142855, which is hereby incorporated by reference in its entirety.

[0077] The publicly available GSE165512 dataset also provides data from expression profiling by high throughput sequencing in order to investigate the molecular mechanisms of IL23-IL17 immune axis in IBD, with particular attention to its role in maintaining mucosal barrier integrity under both physiological and pathological conditions.

[0078] The publicly available GSE174159 dataset provides studies of the variations in VNN1 expression at different stages of the disease and under therapy. A IBD biobank was generated starting with biopsy samples collected from patients suffering from CD or UC and diagnosed as clinically quiescent (Q) or in active phase of the disease (A). Patients were even not-treated at the period of diagnosis (NT) or responders or not to various therapies such as 5-ASA, anti-TNFalpha biologies (aTNF), corticoids (Cort) or immunosuppressors (IS). Controls were taken from non-inflammatory healthy portions of colon (CTRL). Transcriptome profiling was performed with RNA-Seq. Further details regarding the dataset can be found in Millet V, Gensollen T, Maltese M, Serrero M et al., Harnessing the Vnnl pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis. Gut 2023 Jun;72(6):1115-1128. PMID: 36175116, which is hereby incorporated by reference in its entirety.

[0079] The publicly available GSE72819 dataset provides RNA sequencing data performed on RNA isolated from baseline biopsies from UC patients enrolled in the Phase II EUCALYPTUS study of etrolizumab. Gene expression differences were identified in a subset of anti-TNF naive patients that achieved clinical remission at 10 weeks in response to etrolizumab. Further details regarding the dataset can be found in Tew GW, Hackney JA, Gibbons D, Lamb CA et al., Association Between Response to Etrolizumab and Expression of Integrin aE and Granzyme A in Colon Biopsies of Patients with Ulcerative Colitis. Gastroenterology 2016 Feb;150(2):477- 87. e9. PMID: 26522261, which is hereby incorporated by reference in its entirety.

[0080] The publicly available GSE13987 dataset provides gene expression profiling data for PDE4 inhibitors, which activate cAMP signaling by reducing cAMP catabolism, are known to induce apoptosis in B lineage chronic lymphocytic leukemia (CLL) cells but not normal human T cells. The explanation for such differential

[0081] 10

[0082] 4935-6038-7201 , v. 2 sensitivity remains unknown. The studies reported contrasting the response to PDE4 inhibitor treatment in CLL cells and normal human T and B cells. Affymetrix gene chip analysis in the three cell populations following treatment with the PDE4 inhibitor rolipram identified a set of up-regulated transcripts with unusually high foldchanges in the CLL samples, several of which are likely part of compensatory negative feedback loops. The high fold-change were due to low basal transcript levels in CLL cells, suggesting that cAMP-mediated signaling may be unusually tightly regulated in this cell type. Further details regarding this dataset can be found in Meyers JA, Su DW, Lerner A., Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors. J Immunol 2009 May l;182(9):5400-ll. PMID: 19380787, which is hereby incorporated by reference in its entirety.

[0083] The publicly available GSE225904 dataset provides gene expression profiling data for Behcet disease (BD). BD is a systemic vasculitis with inflammatory lesions mediated by cytotoxic T cells and neutrophils. Apremilast, an orally available small-molecule that selectively inhibits phosphodiesterase 4 (PDE4), has been recently approved for the treatment of BD. The studies investigate the effect of PDE4 inhibition on neutrophil activation in BD. The study details can be found in Le Joncour A, Regnier P, Maciejewski-Duval A, Charles E et al., Reduction of Neutrophil Activation by Phosphodiesterase 4 Blockade in Behcet's Disease. Arthritis Rheumatol 2023 Sep;75(9): 1628-1637. PMID: 36862398, which hereby incorporated by reference in its entirety.

[0084] The publicly available GSE133477 dataset provides gene expression data obtained from a clinical trial for mild-to-moderate atopic dermatitis (AD) using crisaborole ointment, 2%, which is a nonsteroidal phosphodiesterase 4 (PDE4) inhibitor. The mechanism of action (MO A) of crisaborole and its effects on lesional measures of disease severity are not yet well-defined. This phase 2a, single-center, vehicle-controlled, intrapatient study was designed to further characterize the MOA of crisaborole through evaluation of clinical efficacy and changes in skin biomarkers in adults (N = 40) with mild-to-moderate AD. Further details of the study can be found in Bissonnette R, Pavel AB, Diaz A, Werth JL et al., Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial. J Allergy Clin Immunol 2019 Nov; 144(5): 1274-1289. PMID: 31419544, which is hereby incorporated by reference in its entirety.

[0085] The publicly available GSE106710 dataset provides microarray analysis that was performed on RNA extracted from BEAS-2B cells treated with indacaterol, GSK 256066 and indacaterol and GSK 256066 in combination to identify differentially expressed genes that may contribute to the beneficial and deleterious effects of 02 -adrenoceptor agonists and phosphodiesterase 4 inhibitors in obstructive lung diseases.

[0086] The publicly available GSE 126981 dataset provides gene expression data obtained from RNA- sequencing, which was performed to study the effect of phosphodiesterase 4 inhibition by Roflumilast N-oxide (RNO) on gene expression changes produced by sub-maximal concentrations of the long acting 02-adrenoceptor agonist, Salmeterol. Our results indicate that RNO enhanced the expression of all salmeterol-regulated genes, but the degree of enhancement varied between genes due to the difference in their sensitivities to salmeterol. Further details of the study can be found in Radhika Joshi, Mark A. Giembycz, et. al. Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol- Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis

[0087] 11

[0088] 4935-6038-7201 , v. 2 Molecular Pharmacology July 2019, 96 (1) 56-72; DOI: https: / / doi.org / 10.1124 / mol.118.115311, which is hereby incorporated by reference in its entirety.

[0089] The publicly available GSE84880 dataset provides microarray analysis that was performed on RNA from BEAS-2B cells treated with GS-5759 and a combination of indacaterol and GSK 256066 to identify differentialy expressed genes. GS-5759 is a bifunctional ligand composed of a quinolinone-containing pharmacophore found in several 02 -adrenoceptor agonists linked covalently to a phosphodiesterase 4 inhibitor (PDE4) related to GSK 256066 by a pent-l-yn-l-ylbenzene spacer. The object of the study was to detemine if gene expression changes induced by GS-5759 were replicated by a 02 -adrenoceptor agonist (indacaterol; Ind) and a PDE4 inhibitor (GSK 256066; GSK) in combination. Further details of the study can be found in Joshi T, Yan D, Hamed O, Tannheimer SL et al., GS-5759, a Bifunctional 02 -Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells. J Pharmacol Exp Ther 2017 Feb;360(2):324- 340. PMID: 27927912, which is hereby incorporated by reference in its entirety.

[0090] MULTINOMIAL LOGISTIC REGRESSION MODELS

[0091] Machine learning models can apply linear regression algorithms, non-linear regression , logistic regression algorithms , classification models , bootstrap resampling models , subset selection models , dimensionality reduction models , tree - based models ( such as bagging , boosting , and random forest), and other supervised or unsupervised models. As each model is selected, a target output may be requested from the user specifying which feature (s) the model should identify, classify, and / or report.

[0092] One embodiment of the invention discloses a multinomial logistic regression model. The multinomial logistic regression has been widely used to study multiple unordered outcome categories (and possibly their combination) simultaneously. See Biesheuvel et al., Polytomous logistic regression analysis could be applied more often in diagnostic research. J Clin Epidemiol. 2008;61(2):125-34. The multinomial logistic model can be considered to be an extension of the popular binary logistic regression model, which is often used in the presence of two mutually exclusive outcome categories. More specifically, multinomial logistic regression analysis can be viewed as a series of binary logistic regression analyses where one of the outcome categories is the reference category in each binary sub-model. See Smeden, et al.. Diagnostic and Prognostic Research (2017) 1:8, DOI 10.1186 / s41512-017-0010-5, which is hereby incorporated by reference in its entirety.

[0093] A multinomial logistic regression model for precision medicine can be represented by the formula: log(P(Y=j) / P(Y=ref)) = 0oj + 0ijXi + 02jX> + ... + 0pjXp; where "j" represents each possible treatment response category (e.g., "excellent response", "partial response", "no response"), "ref' is a chosen reference category, "X" are patient characteristics (like genetic markers) used as predictors, and "0" are the regression coefficients for each predictor in relation to each response category compared to the reference category. See Semden et al., Diagnostic and Prognostic Research (2017) 1:8 DOI 10.1186 / s41512-017-0010-5, which is hereby incorporated by reference in its entirety.

[0094] Furthermore, the multinomial logistic regression model (MLR) can be used in health care when the primary outcome of interest has more than two categories. The application of the multinomial logistic regression model in clinical settings where the prediction of a multicategory outcome is of interest provides specific

[0095] 12

[0096] 4935-6038-7201 , v. 2 advantages over a binary model. Thus future methodological research could focus on MLR-specific considerations for variable selection and sample size criteria for external validation. See Gehringer et al., Journal of Clinical Epidemiology 174 (2024) 111481, which is hereby incorporated by reference in its entirety.

[0097] Some machine learning algorithms may identify features of importance and identify a coefficient, or weight, to the features obtained from the machine learning operation. The coefficient may be multiplied with the occurrence frequency of the feature to generate a score, and once the scores of one or more features exceed a threshold, certain classifications may be predicted by the machine learning model. See U.S. Patent No. 11,699,507, which is hereby incorporated by reference in its entirety.

[0098] Weighted gene co-expression network analysis is a sophisticated systems biology method used to elucidate the correlation patterns among genes across microarray samples. This approach facilitates the identification of gene sets that exhibit strong covariation and can reveal potential candidate biomarker genes or therapeutic targets by exploring the inherent connections within the gene set and their correlation with the phenotype. See Yang, et al. Computers in Biology and Medicine 168 (2024) 107778, which is hereby incorporated by reference in its entirety. The weighted correlation network analysis can also be performed using an R package software. See BMC Bioinformatics 9, Article number: 559(2008) , which also is hereby incorporated by reference in its entirety.

[0099] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more of, two or more of, three or more of, four or more of, five or more of, six or more of, seven or more of, eight or more of, nine or more of, ten or more of, eleven or more of, twelve or more of, thirteen or more of , fourteen or more of, fifteen or more of, sixteen or more of, seventeen or more of, eighteen or more of, nineteen or more of, twenty or more of, or are all twenty one of genes selected from the group consisting of: AVPI1, CALR, CCL4, CSF3, CXCL8, CXCR1, DUOXA2, HCAR3, IGHG1, IL1B, IL6, ITPRIP, LUCAT1, MMP1, MMP2, NFKBIZ, NOS2, ODC1, PRPS1, S100A12, anASELE.

[0100] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, five or more, or all six genes selected from the group consisting of: DUOXA2, LUCAT1, CXCR1, CCL4, MMP1 wAMMP2.

[0101] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, five or more, or all six genes selected from the group consisting of: CSF3, DUOXA2, HCAR3, CCL4, IL1B and CXCL8.

[0102] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, CXCR1, S100A12, LUCAT1 and SELE.

[0103] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CCL4, ITPRIP, PRPS1 , A VPI1 and NOS2.

[0104] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, HCAR3, CXCR1, L UCAT1 and SELE.

[0105] 13

[0106] 4935-6038-7201 , v. 2 In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, HCAR3, CCL4, S100A12 and SELE.

[0107] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: 0DC1, IL6, ITPRIP, CXCR1 and NOS2.

[0108] In certain embodiments, the sample domain of genes, or the top set of genes includes one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: 0DC1, NFKBIZ, CCL4, IGHG1, and CALR.

[0109] CORRELATION

[0110] As used herein, “correlation” means, when applied to a set of genes, that expression levels of the members of the set display a statistically significant tendency to increase or decrease in concert, with a given type of tissue, e.g. colonic mucosal biopsy specimens. Without intending to be bound by theory, it noted that correlation is likely to indicate that the correlated genes share a common involvement in one or more biological functions.

[0111] Historically, many investigators have found correlations between expression levels of certain genes and a biological condition or phenotype of interest. Such correlations, however, have had very limited usefulness. This is because the correlations typically do not hold up across datasets, e.g., human colonic mucosal biopsy specimens vs. similar specimens from a mouse model; or one gene expression technology platform vs. another gene expression technology platform.

[0112] The subject disclosure overcomes this pitfail by identifying gene expression correlations that are observed across multiple, diverse datasets. By applying machine learning model analysis to measured RNA expression values across multiple independent data sets, the universe of transcribed human genes have been sorted, the “transcriptome,” into non-overlapping sets of genes whose expression levels, in terms of transcriptional flux, move (increase or decrease) together. The coordinated variation in gene transcript level observed across multiple data sets is an empirical phenomenon called “coherence.”

[0113] In some aspects, the correlation analysis may employ statistical methods such as Pearson correlation or Spearman correlation to quantify the relationship between expression levels of gene pairs across samples. For each gene in a candidate gene set, a correlation coefficient (R-value) may be calculated with respect to other genes in the set, wherein the R-value ranges from -1 to 1, with positive values indicating that expression levels tend to increase together and negative values indicating that expression levels tend to move in opposite directions. Genes displaying statistically significant correlation (e.g., passing a user-specified p-value cutoff such as p < 0.01) may be identified as co-correlated genes suitable for inclusion in a predictive gene signature.

[0114] 14

[0115] 4935-6038-7201 , v. 2 In some embodiments, the correlation analysis may identify an anchor gene, which may be defined as the gene within a candidate gene set that has the highest average correlation coefficient to the other genes in the set across all samples being evaluated. The anchor gene may serve as a reference point for assessing the correlation behavior of other genes in the set. Genes that positively correlate with the anchor gene and genes that negatively correlate (anti-correlate) with the anchor gene may both contribute to the overall predictive value of the gene signature, as anti-correlated genes may represent opposing biological processes or states relevant to the phenotype of interest.

[0116] The concept of coherence, as used herein, reflects the observation that genes participating in a common biological pathway or function tend to be regulated together, such that their expression levels show correlated patterns across diverse biological samples. Without intending to be bound by theory, this coordinated regulation may arise because genes in the same pathway are subject to common transcriptional regulatory mechanisms, respond to common signaling inputs, or are functionally interdependent. By identifying gene sets that display coherent expression patterns, the methods described herein may capture biologically meaningful relationships that are more likely to be reproducible across different experimental conditions, tissue types, and technology platforms.

[0117] In some aspects, the iterative refinement of a gene signature may involve repeated addition or removal of genes from a candidate gene set to maximize the number of genes whose expression is co-correlated across multiple independent datasets. This iterative process may strengthen the association of genes within a particular tissue or disease type while also broadening the applicability of the signature to multiple tissue types or patient populations. For example, genes that do not show consistent correlation patterns across datasets may be excluded, while genes that demonstrate robust co -correlation across diverse datasets may be retained or added to the signature.

[0118] In certain embodiments, the use of multiple independent datasets in developing and validating a gene signature may address limitations observed with prior approaches. Gene signatures developed using only a single dataset or a single experimental model system may fail to generalize to other contexts, such as different patient populations, different tissue sources, or different gene expression measurement platforms. By requiring that genes in a signature display coherent expression patterns across multiple, diverse datasets — such as datasets derived from different institutions, different microarray platforms, or different sequencing technologies — the methods described herein may yield gene signatures with improved robustness and predictive power in clinical applications.

[0119] In some embodiments, the coherence of a gene set may be visualized using correlation maps or heat maps that display the pairwise correlation coefficients between genes in the set. Waterfall plots may also be used to display index scores calculated from the gene signature across a population of samples, allowing visualization of the distribution of scores and identification of samples with high or low index values. Such visualizations may aid in assessing the quality of a gene signature and its ability to discriminate between biological states of interest, such as responder versus non-responder status.

[0120] 15

[0121] 4935-6038-7201 , v. 2 METHODS OF TREATMENT

[0122] According to exemplary embodiments, the present application provides methods of treating a subject with an inflammatory bowel disease that include classifying the human subject with inflammatory bowel disease as a likely responder or non-responder to a PDE4 inhibitor (e.g., a PDE4B inhibitor or a PDE4D inhibitor) based on a comparison of the PDE4 Inhibitor Resistance Metric (PIRM) with a reference PDE4 Inhibitor Resistance Metric. In certain embodiments, the reference PDE4 Inhibitor Resistance Metric corresponds to a cut-off value, wherein the PDE4 inhibitor is administered if the reference PDE4 Inhibitor Resistance Metric is below the cutoff value.

[0123] While a lower PDE4 Inhibitor Resistance Metric (PIRM) can, in certain embodiments, trend toward a treatment decision (vs. non-treatment) and a PDE4 inhibitor is administered if the PIRM is below the cutoff value (i.e., below the reference PIRM), it is understood that the inverse can apply within the scope of the present application. More precisely, the PDE4 Inhibitor Resistance Metric can represent a value such that a higher value will trend toward a decision to administer a PDE4 inhibitor, and where, for example, a PDE4 inhibitor is administered if the PIRM is above the reference PIRM.

[0124] The embodiments of the subject application are generally directed to inflammatory bowel diseases. Nevertheless, in certain embodiments, inflammatory response genes are measured and input into the instantly disclosed models. Accordingly, embodiments of the subject disclosure also relate to inflammatory diseases in general. For brevity, all references to inflammatory bowel diseases throughout the subject disclosure should be taken as the same reference to inflammatory diseases generally.

[0125] Tissue Samples

[0126] According to exemplary embodiments, a tissue sample from, for example, a colonic mucosal biopsy specimen, or a blood sample from a human patient, or in a mouse model can be used as a source of RNA, so that an individual mean expression score for each transcription cluster, and a population mean expression score for each transcription cluster, can be determined. The tissue sample can be obtained by using conventional tumor biopsy instruments and procedures. Endoscopic biopsy, excisional biopsy, incisional biopsy, fine needle biopsy, punch biopsy, shave biopsy and skin biopsy are examples of recognized medical procedures that can be used by one of skill in the art to obtain biopsy samples for use in practicing the invention. The tissue sample should be large enough to provide sufficient RNA for measuring individual gene expression levels.

[0127] The tissue sample can be in any form that allows quantitative analysis of gene expression or transcript abundance. In some exemplary embodiments, RNA is isolated from the tissue sample prior to quantitative analysis. Some methods of RNA analysis, however, do not require RNA extraction, e.g., the gNPA™ technology commercially available from High Throughput Genomics, Inc. (Tucson, Ariz.). Accordingly, the tissue sample can be fresh, preserved through suitable cryogenic techniques, or preserved through non- cryogenic techniques. Tissue samples used in the invention can be clinical biopsy specimens, which often are fixed in formalin and then embedded in paraffin. Samples in this form are commonly known as formalin-fixed, paraffin-embedded (FFPE) tissue. Techniques of tissue preparation and tissue preservation suitable for use in the present invention are well-known to those skilled in the art.

[0128] 16

[0129] 4935-6038-7201 , v. 2 In certain exemplary embodiments, since transcript profiling offers the largest coverage and a wide dynamic range of gene expression information that can often be performed genome wide, expression levels for a representative number of genes from a given transcription cluster are the input values used to calculate the individual mean expression score for that transcription cluster, in a given tissue sample. Each tissue sample is a member of a population, e.g., a sensitive population or a resistant population. The individual mean expression scores for all the individuals in a given population then are used to calculate the population mean expression score for a given transcription cluster, in a given population. So for each tissue sample, it is necessary to determine, i.e., measure, the expression levels of individual genes in a transcription cluster. Gene expression levels (transcript abundance) can be determined by any suitable method. Exemplary methods for measuring individual gene expression levels include DNA microarray analysis, qRT-PCR, gNPA™, the NanoString® technology, and the QuantiGene® Plex assay system.

[0130] Alternatively, protein levels can be measured directly according to another exemplary embodiment. Gene expression is a highly regulated, multistep process, and determining protein concentration or activity from the measurement of mRNA levels may prove to be difficult in certain circumstances. Proteomics has therefore become a key tool in systems biology because it provides quantitative and structural information about proteins, which are the major functional determinants of cells. Phenotypic alterations associated with genetic perturbations often result from changes in protein accumulation or stability, or changes in protein posttranslational modifications, which can disrupt protein-protein interactions and network connectivity. Gstaiger M, Aebersold R, Applying mass spectrometry-based proteomics to genetics, genomics and network bioiogv Nat Rev Genet 10 617-627. Quantitative protein information complements data from transcriptional profiling and metabolomics. It represents a key link between different levels of gene expression regulation and provides insights into their causal relationships.

[0131] In some embodiments, the methods described herein may be performed using a gene panel. A gene panel, as used herein, refers to a collection of genes whose expression levels are measured simultaneously or in a coordinated manner, such as through a multiplex assay, microarray, or sequencing platform. While the gene sets described herein include particular genes associated with predicting response to PDE4 inhibitor therapy, the gene panel may also encompass genes associated with other methodologies and biological pathways. For example, a gene panel may include biomarkers for assessing disease severity, monitoring treatment response, evaluating other therapeutic modalities, or analyzing additional signaling pathways relevant to inflammatory bowel disease or other conditions. Accordingly, in some embodiments, the gene panel consists of at least 30, at least 40, or at least 50 biomarkers (e.g. 50-100 biomarkers), thereby enabling comprehensive analysis across multiple methodologies and pathways in a single assay. Alternatively, in other embodiments, the gene panel may consist of a smaller number of biomarkers, such as from about 6 to about 9 biomarkers, wherein the methods described herein for predicting PDE4 inhibitor response may comprise the entirety of the analysis performed using the gene panel.

[0132] 17

[0133] 4935-6038-7201 , v. 2 RNA Isolation

[0134] DNA microarray analysis and qRT-PCR generally involves RNA isolation from a tissue sample. Methods for rapid and efficient extraction of eukaryotic mRNA, i.e., poly(a) RNA, from tissue samples are well-established and known to those of skill in the art. See, e.g., Ausubel et al., 1997, Current Protocols of Molecular Biology, John Wiley & Sons. The tissue sample can be fresh, frozen or fixed paraffin-embedded (FFPE) clinical study colonic mucosal biopsy specimens. In general, RNA isolated from fresh or frozen tissue samples tends to be less fragmented than RNA from FFPE samples and are preferred in certain embodiments. FFPE samples of colonic mucosal biopsy material, however, are more readily available, and FFPE samples are thus also suitable sources of RNA for use in methods of the subject disclosure and preferred according to other exemplary embodiments of the subject disclosure. For a discussion of FFPE samples as sources of RNA for gene expression profiling by RT-PCR, see, e.g., Clark-Langone et al., 2007, BMC Genomics 8:279. Also see, De Andres et al., 1995, Biotechniques 18:42044; and Baker et al., U.S. Patent Application Publication No. 2005 / 0095634. The use of commercially available kits with vendor's instructions for RNA extraction and preparation is widespread and common. Commercial vendors of various RNA isolation products and complete kits include Qiagen (Valencia, Calif.), Invitrogen (Carlsbad, Calif.), Ambion (Austin, Tex.) and Exiqon (Woburn, Mass.).

[0135] In general, RNA isolation involves an initial tissue / cell disruption operation. During tissue / cell disruption, it is desirable to minimize RNA degradation by RNases. One approach to limiting RNase activity during the RNA isolation process is to ensure that a denaturant is in contact with cellular contents as soon as the cells are disrupted. Another common practice is to include one or more proteases in the RNA isolation process. Optionally, fresh tissue samples are immersed in an RNA stabilization solution, at room temperature, as soon as they are collected. The stabilization solution rapidly permeates the cells, stabilizing the RNA for storage at 4° C., for subsequent isolation. One such stabilization solution is available commercially as RNAlater® (Ambion, Austin, Tex.). Other techniques will present themselves to one of ordinary skill in the art.

[0136] In certain exemplary embodiments, total RNA is isolated from disrupted colonic mucosal biopsy material by cesium chloride density gradient centrifugation. In general, mRNA makes up approximately 1% to 5% of total cellular RNA. Immobilized oligo(dT), e.g., oligo(dT) cellulose, is commonly used to separate mRNA from ribosomal RNA and transfer RNA. If stored after isolation, RNA must be stored under RNase-free conditions. Methods for stable storage of isolated RNA are known in the art. Various commercial products for stable storage of RNA are available.

[0137] Microarray Analysis

[0138] The mRNA expression level for multiple genes can be measured using conventional DNA microarray expression profiling technology. A DNA microarray is a collection of specific DNA segments or probes affixed to a solid surface or substrate such as glass, plastic or silicon, with each specific DNA segment occupying a known location in the array. Hybridization with a sample of labeled RNA, usually under stringent hybridization conditions, allows detection and quantitation of RNA molecules corresponding to each probe in the array. After stringent washing to remove non-specifically bound sample material, the microarray is scanned by confocal

[0139] 18

[0140] 4935-6038-7201 , v. 2 laser microscopy or other suitable detection method. Modem commercial DNA microarrays, often known as DNA chips, typically contain tens of thousands of probes, and thus can measure expression of tens of thousands of genes simultaneously. Such microarrays can be used in practicing the disclosed methods. Alternatively, custom chips containing as few probes as those needed to measure expression of the genes of the transcription clusters, plus any desired controls or standards.

[0141] To facilitate data normalization, a two-color microarray reader can be used according to exemplary embodiments of the subject disclosure. In an exemplary two-color (two-channel) system, samples are labeled with a first fluorophore that emits at a first wavelength, while an RNA or cDNA standard is labeled with a second fluorophore that emits at a different wavelength. For example, Cy3 (570 nm) and Cy5 (670 nm) often are employed together in two-color microarray systems.

[0142] DNA microarray technology is well-developed, commercially available, and widely employed. Therefore, in performing the methods disclosed herein, the skilled person can use microarray technology to measure expression levels of genes in the transcription cluster by additional techniques known in the art. DNA microarray chips, reagents (such as those for RNA or cDNA preparation, RNA or cDNA labeling, hybridization and washing solutions), instruments (such as microarray readers) and protocols are available from various commercial sources, including Agilent Technologies (Santa Clara, Calif.) and Affymetrix (Santa Clara, Calif.), although other microarray systems can be used.

[0143] Quantitative RT-PCR

[0144] The level of mRNA representing individual genes in a transcription cluster can be measured using conventional quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) technology. Advantages of qRT-PCR include sensitivity, flexibility, quantitative accuracy, and ability to discriminate between closely related mRNAs. Guidance concerning the processing of tissue samples for quantitative PCR is available from, for example, vendors of commercial products for qRT-PCR (e.g., Qiagen (Valencia, Calif.) and Ambion (Austin, Tex.)). Instrument systems for automated performance of qRT-PCR are commercially available and routinely used. An example of a well-known commercial system is the Applied Biosystems 7900HT Fast Real- Time PCR System (Applied Biosystems, Foster City, Calif.).

[0145] Once isolated mRNA is in hand, the first step in gene expression profiling by RT-PCR is the reverse transcription of the mRNA template into cDNA, which is then exponentially amplified in a PCR reaction. Two commonly used reverse transcriptases are avilo myeloblastosis virus reverse transcriptase (AMV-RT) and Moloney murine leukemia virus reverse transcriptase (MMLV-RT). The reverse transcription reaction typically is primed with specific primers, random hexamers, or oligo(dT) primers. Suitable primers are commercially available, e.g., GeneAmp® RNA PCR kit (Perkin Elmer, Waltham, Mass.). The resulting cDNA product can be used as a template in the subsequent polymerase chain reaction.

[0146] The PCR step can be carried out using a thermostable DNA-dependent DNA polymerase (e.g., a Thermus aquations (Taq) polymerase). The selectivity of PCR results from the use of primers that are complementary to the DNA region targeted for amplification, i.e., regions of the cDNAs reverse transcribed from the genes of the Transcription Cluster. Therefore, when qRT-PCR is employed in exemplary embodiments

[0147] 19

[0148] 4935-6038-7201 , v. 2 of the subject disclosure, primers specific to each gene in a given Transcription Cluster are based on the cDNA sequence of the gene. Commercial technologies such as SYBR® green or TaqMan® (Applied Biosystems, Foster City, Calif.) can be used in accordance with the vendor's instructions. Messenger RNA levels can be normalized for differences in loading among samples by comparing the levels of housekeeping genes such as beta-actin or GAPDH. The level of mRNA expression can be expressed relative to any single control sample such as mRNA from normal, non- colonic mucosal biopsy tissue or cells. Alternatively, it can be expressed relative to mRNA from a pool of colonic mucosal biopsy samples, or colonic mucosal biopsy cell lines, or from a commercially available set of control mRNA.

[0149] Suitable primer sets for PCR analysis of expression levels of genes in a transcription cluster can be designed and synthesized by one of skill in the art, without undue experimentation. Alternatively, complete PCR primer sets for practicing the disclosed methods can be purchased from commercial sources, e.g., Applied Biosystems, based on the identities of genes. PCR primers can be about 17 to 25 nucleotides in length. Primers can be designed to have a particular melting temperature (Tm), using conventional algorithms for Tm estimation. Software for primer design and Tm estimation are available commercially, e.g., Primer Express™ (Applied Biosystems), and also are available on the internet, e.g., Primer3 (Massachusetts Institute of Technology). By applying established principles of PCR primer design, a large number of different primers can be used to measure the expression level of any given gene. Accordingly, the disclosed methods are not limited with respect to which particular primers are used for any given gene in a transcription cluster.

[0150] In another embodiment, Proximity Extension Assay (PEA) technology, a proteomics platform enabling highly specific and scalable protein detection, available from Olink (now part of Thermo Fisher Scientific) is employed to analyze gene panels.

[0151] Quantitative Nuclease Protection Assay

[0152] An example of a suitable method for determining expression levels of genes in a transcription cluster without performing an RNA extraction step is the quantitative nuclease protection assay (qNPA™), which is commercially available from High Throughput Genomics, Inc. (aka “HTG”; Tucson, Ariz.). In the qNPA method, samples are treated in a 96-well plate with a proprietary Lysis Buffer (HTG), which releases total RNA into solution. Gene-specific DNA oligonucleotides, i.e., specific for each gene in a given Transcription Cluster, are added directly to the Lysis Buffer solution, and they hybridize to the RNA present in the Lysis Buffer solution. The DNA oligonucleotides are added in excess, to ensure that all RNA molecules complementary to the DNA oligonucleotides are hybridized. After the hybridization step, SI nuclease is added to the mixture. The SI nuclease digests the non-hybridized portion of the target RNA, all of the non-target RNA, and excess DNA oligonucleotides. Then the SI nuclease enzyme is inactivated. The RNA::DNA heteroduplexes are treated to remove the RNA portion of the duplex, leaving only the previously protected oligonucleotide probes. The surviving DNA oligonucleotides are a stoichiometrically representative library of the original RNA sample. The qNPA oligonucleotide library can be quantified using the ArrayPlate Detection System (HTG).

[0153] 20

[0154] 4935-6038-7201 , v. 2 NanoString® nCounter" Analysis

[0155] Another example of a technology suitable for determining expression levels of genes in a transcription cluster is a commercially available assay system based on probes with molecular “barcodes” is the NanoString® nCounter™ Analysis system (NanoString® Technologies, Seattle, Wash.). This system is designed to detect and count hundreds of unique transcripts in a single reaction. Each color-coded barcode is attached to a single targetspecific probe corresponding to a gene interest, e.g., a gene in a transcription cluster. When mixed together with controls, probes form a multiplexed “CodeSet.” The NanoString® technology employs two approximately 50- base probes per mRNA, that hybridize in solution. A “reporter probe” carries the signal, and a “capture probe” allows the complex to be immobilized for data collection. After hybridization, the excess probes are removed, and the probe / target complexes are aligned and immobilized in nCounter® cartridges, which are placed in a digital analyzer. The nCounter® analysis system is an integrated system comprising an automated sample prep station, a digital analyzer, the CodeSet (molecular barcodes), and all of the reagents and consumables needed to perform the analysis.

[0156] QuantiGene® Plex Assay

[0157] Another example of a technology suitable for determining expression levels of genes in a transcription cluster is a commercially available assay system known as the QuantiGene® Plex Assay (Panomics, Fremont, Calif.). This technology combines branched DNA signal amplification with xMAP (multi-analyte profiling) beads, to enable simultaneous quantification of multiple RNA targets directly from fresh, frozen or FFPE tissue samples, or purified RNA preparations. For further description of this technology, see, e.g., Flagella et al., 2006, Anal. Biochem. 352:50-60.

[0158] Embodiments of the present disclosure include methods for treating a subject with an inflammatory bowel disease (or other indications disclosed herein), the methods including obtaining a biological sample from the subject with the, e.g., inflammatory bowel disease; and measuring gene expression levels of, for example, 6 to 9 genes as part of a gene panel. In embodiments, the measured genes can include two, three, four, five, or six of the following genes: ; 1. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2; 2. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3; 3. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12; 4. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, SELE; 5. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, HCAR3; 6. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, ODC1; 7. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, IL6; 8. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, ITPRIP; 9. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, NOS2; 10. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3;11. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12; 12. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, SELE; 13. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, HCAR3; 14. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, ODC1; 15. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, IL6; 16. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, ITPRIP; 17. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, NOS2; 18. DUOXA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12; 19. DUOXA2, LUCAT1, CXCR1, CCL4, CSF3, SELE; 20. DUOXA2, LUCAT1, CXCR1, CCL4, CSF3, HCAR3; 21. DUOXA2, LUCAT1, CXCR1, CCL4, CSF3, ODC1; 22. DUOXA2, LUCAT1, CXCR1, CCL4, CSF3, IL6; 23. DUOXA2, LUCAT1, CXCR1,

[0159] 21

[0160] 4935-6038-7201 , v. 2 CCL4, CSF3, ITPRLP; 24. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, NOS2; 25. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, SELE; 26. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, HCAR3; 27. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, ODC1; 28. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, IL6; 29. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, ITPRIP; 30. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, N0S2; 31. DU0XA2, LUCAT1, CXCR1, CCL4, SELE, HCAR3; 32. DU0XA2, LUCAT1, CXCR1, CCL4, SELE, 0DC1; 33. DU0XA2, LUCAT1, CXCR1, CCL4, SELE, IL6; 34. DU0XA2, LUCAT1, CXCR1, CCL4, SELE, ITPRLP; 35. DU0XA2, LUCAT1, CXCR1, CCL4, SELE, N0S2; 36. DU0XA2, LUCAT1, CXCR1, CCL4, HCAR3, 0DC1; 37. DU0XA2, LUCAT1, CXCR1, CCL4, HCAR3, IL6; 38. DU0XA2, LUCAT1, CXCR1, CCL4, HCAR3, ITPRLP; 39. DU0XA2, LUCAT1, CXCR1, CCL4, HCAR3, N0S2; 40. DU0XA2, LUCAT1, CXCR1, CCL4, 0DC1, IL6; 41. DU0XA2, LUCAT1, CXCR1, CCL4, 0DC1, ITPRLP; 42. DU0XA2, LUCAT1, CXCR1, CCL4, 0DC1, N0S2; 43. DU0XA2, LUCAT1, CXCR1, CCL4, IL6, ITPRLP; 44. DU0XA2, LUCAT1, CXCR1, CCL4, IL6, N0S2; 45. DU0XA2, LUCAT1, CXCR1, CCL4, ITPRLP, N0S2; 46. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3; 47. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, S100A12; 48. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, SELE; 49. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, HCAR3; 50. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, 0DC1; 51. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, IL6; 52. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, ITPRLP; 53. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, N0S2; 54. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12; 55. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, SELE; 56. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, HCAR3; 57. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, 0DC1; 58. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, IL6; 59. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, ITPRLP; 60. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, N0S2; 61. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, SELE; 62. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, HCAR3; 63. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, 0DC1; 64. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, IL6; 65. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, ITPRLP; 66. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, N0S2; 67. DU0XA2, LUCAT1, CXCR1, MMP1, SELE, HCAR3; 68. DU0XA2, LUCAT1, CXCR1, MMP1, SELE, 0DC1; 69. DU0XA2, LUCAT1, CXCR1, MMP1, SELE, IL6; 70. DU0XA2, LUCAT1, CXCR1, MMP1, SELE, ITPRLP; 71. DU0XA2, LUCAT1, CXCR1, MMP1, SELE, N0S2; 72. DU0XA2, LUCAT1, CXCR1, MMP1, HCAR3, 0DC1; 73. DU0XA2, LUCAT1, CXCR1, MMP1, HCAR3, IL6; 74. DU0XA2, LUCAT1, CXCR1, MMP1, HCAR3, ITPRLP; 75. DU0XA2, LUCAT1, CXCR1, MMP1, HCAR3, N0S2; 76. DU0XA2, LUCAT1, CXCR1, MMP1, 0DC1, IL6; 77. DU0XA2, LUCAT1, CXCR1, MMP1, 0DC1, ITPRLP; 78. DU0XA2, LUCAT1, CXCR1, MMP1, 0DC1, N0S2; 79. DU0XA2, LUCAT1, CXCR1, MMP1, IL6, ITPRLP; 80. DU0XA2, LUCAT1, CXCR1, MMP1, IL6, N0S2; 81. DU0XA2, LUCAT1, CXCR1, MMP1, ITPRLP, N0S2; 82. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12; 83. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, SELE; 84. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, HCAR3; 85. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, 0DC1; 86. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, IL6; 87. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, ITPRLP; 88. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, N0S2; 89. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, SELE; 90. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, HCAR3; 91. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, 0DC1; 92. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, IL6; 93. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, ITPRLP; 94. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, N0S2; 95. DU0XA2, LUCAT1, CXCR1, MMP2, SELE, HCAR3; 96. DU0XA2, LUCAT1, CXCR1, MMP2, SELE, 0DC1; 97. DU0XA2, LUCAT1, CXCR1, MMP2, SELE, IL6; 98. DU0XA2, LUCAT1, CXCR1, MMP2, SELE, ITPRLP; 99. DU0XA2, LUCAT1,

[0161] 22

[0162] 4935-6038-7201 , v. 2 CXCR1, MMP2, SELE, NOS2; 100. DU0XA2, LUCAT1, CXCR1, MMP2, HCAR3, ODC1; 101. DU0XA2, LUCAT1, CXCR1, MMP2, HCAR3, IL6; 102. DU0XA2, LUCAT1, CXCR1, MMP2, HCAR3, ITPRIP; 103. DU0XA2, LUCAT1, CXCR1, MMP2, HCAR3, N0S2; 104. DU0XA2, LUCAT1, CXCR1, MMP2, 0DC1, IL6; 105. DU0XA2, LUCAT1, CXCR1, MMP2, 0DC1, ITPRIP; 106. DU0XA2, LUCAT1, CXCR1, MMP2, 0DC1, N0S2; 107. DU0XA2, LUCAT1, CXCR1, MMP2, IL6, ITPRIP; 108. DU0XA2, LUCAT1, CXCR1, MMP2, IL6, N0S2; 109. DU0XA2, LUCAT1, CXCR1, MMP2, ITPRIP, N0S2; 110. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12, SELE; 111. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12, HCAR3; 112. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12, 0DC1; 113. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12, IL6; 114. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12, ITPRIP; 115. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12, N0S2; 116. DU0XA2, LUCAT1, CXCR1, CSF3, SELE, HCAR3; 117. DU0XA2, LUCAT1, CXCR1, CSF3, SELE, 0DC1; 118. DU0XA2, LUCAT1, CXCR1, CSF3, SELE, IL6; 119. DU0XA2, LUCAT1, CXCR1, CSF3, SELE, ITPRLP; 120. DU0XA2, LUCAT1, CXCR1, CSF3, SELE, N0S2; 121. DU0XA2, LUCAT1, CXCR1, CSF3, HCAR3, 0DC1; 122. DU0XA2, LUCAT1, CXCR1, CSF3, HCAR3, IL6; 123. DU0XA2, LUCAT1, CXCR1, CSF3, HCAR3, ITPRLP; 124. DU0XA2, LUCAT1, CXCR1, CSF3, HCAR3, N0S2; 125. DU0XA2, LUCAT1, CXCR1, CSF3, 0DC1, IL6; 126. DU0XA2, LUCAT1, CXCR1, CSF3, 0DC1, ITPRLP; 127. DU0XA2, LUCAT1, CXCR1, CSF3, 0DC1, N0S2; 128. DU0XA2, LUCAT1, CXCR1, CSF3, IL6, ITPRLP; 129. DU0XA2, LUCAT1, CXCR1, CSF3, IL6, N0S2; 130. DU0XA2, LUCAT1, CXCR1, CSF3, ITPRLP, N0S2; 131. DU0XA2, LUCAT1, CXCR1, S100A12, SELE, HCAR3; 132. DU0XA2, LUCAT1, CXCR1, S100A12, SELE, 0DC1; 133. DU0XA2, LUCAT1, CXCR1, S100A12, SELE, IL6; 134. DU0XA2, LUCAT1, CXCR1, S100A12, SELE, ITPRLP; 135. DU0XA2, LUCAT1, CXCR1, S100A12, SELE, N0S2; 136. DU0XA2, LUCAT1, CXCR1, S100A12, HCAR3, 0DC1; 137. DU0XA2, LUCAT1, CXCR1, S100A12, HCAR3, IL6; 138. DU0XA2, LUCAT1, CXCR1, S100A12, HCAR3, ITPRLP; 139. DU0XA2, LUCAT1, CXCR1, S100A12, HCAR3, N0S2; 140. DU0XA2, LUCAT1, CXCR1, S100A12, 0DC1, IL6; 141. DU0XA2, LUCAT1, CXCR1, S100A12, 0DC1, ITPRLP; 142. DU0XA2, LUCAT1, CXCR1, S100A12, 0DC1, N0S2; 143. DU0XA2, LUCAT1, CXCR1, S100A12, IL6, ITPRLP; 144. DU0XA2, LUCAT1, CXCR1, S100A12, IL6, N0S2; 145. DU0XA2, LUCAT1, CXCR1, S100A12, ITPRLP, N0S2; 146. DU0XA2, LUCAT1, CXCR1, SELE, HCAR3, 0DC1; 147. DU0XA2, LUCAT1, CXCR1, SELE, HCAR3, IL6; 148. DU0XA2, LUCAT1, CXCR1, SELE, HCAR3, ITPRLP; 149. DU0XA2, LUCAT1, CXCR1, SELE, HCAR3, N0S2; 150. DU0XA2, LUCAT1, CXCR1, SELE, 0DC1, IL6; 151. DU0XA2, LUCAT1, CXCR1, SELE, 0DC1, ITPRLP; 152. DU0XA2, LUCAT1, CXCR1, SELE, 0DC1, N0S2; 153. DU0XA2, LUCAT1, CXCR1, SELE, IL6, ITPRLP; 154. DU0XA2, LUCAT1, CXCR1, SELE, IL6, N0S2; 155. DU0XA2, LUCAT1, CXCR1, SELE, ITPRLP, N0S2; 156. DU0XA2, LUCAT1, CXCR1, HCAR3, 0DC1, IL6; 157. DU0XA2, LUCAT1, CXCR1, HCAR3, 0DC1, ITPRLP; 158. DU0XA2, LUCAT1, CXCR1, HCAR3, 0DC1, N0S2; 159. DU0XA2, LUCAT1, CXCR1, HCAR3, IL6, ITPRLP; 160. DU0XA2, LUCAT1, CXCR1, HCAR3, IL6, N0S2; 161. DU0XA2, LUCAT1, CXCR1, HCAR3, ITPRLP, N0S2; 162. DU0XA2, LUCAT1, CXCR1, 0DC1, IL6, ITPRLP; 163. DU0XA2, LUCAT1, CXCR1, 0DC1, IL6, N0S2; 164. DU0XA2, LUCAT1, CXCR1, 0DC1, ITPRLP, N0S2; 165. DU0XA2, LUCAT1, CXCR1, IL6, ITPRLP, N0S2; 166. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3; 167. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12; 168. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, SELE; 169. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, HCAR3; 170. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, 0DC1; 171. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, IL6; 172. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, ITPRLP; 173. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, N0S2; 174.

[0163] 23

[0164] 4935-6038-7201 , v. 2 DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12; 175. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, SEL - 176. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, HCAR3; 177. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, ODC1; 178. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, IL6; 179. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, ITPRLP; 180. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, N0S2; 181. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, SELE; 182. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, HCAR3; 183. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, ODC1; 184. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, IL6; 185. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, ITPRLP; 186. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, N0S2; 187. DU0XA2, LUCAT1, CCL4, MMP1, SELE, HCAR3; 188. DU0XA2, LUCAT1, CCL4, MMP1, SELE, 0DC1; 189. DU0XA2, LUCAT1, CCL4, MMP1, SELE, IL6; 190. DU0XA2, LUCAT1, CCL4, MMP1, SELE, ITPRLP; 191. DU0XA2, LUCAT1, CCL4, MMP1, SELE, N0S2; 192. DU0XA2, LUCAT1, CCL4, MMP1, HCAR3, 0DC1; 193. DU0XA2, LUCAT1, CCL4, MMP1, HCAR3, IL6; 194. DU0XA2, LUCAT1, CCL4, MMP1, HCAR3, ITPRLP; 195. DU0XA2, LUCAT1, CCL4, MMP1, HCAR3, N0S2; 196. DU0XA2, LUCAT1, CCL4, MMP1, 0DC1, IL6; 197. DU0XA2, LUCAT1, CCL4, MMP1, 0DC1, ITPRLP; 198. DU0XA2, LUCAT1, CCL4, MMP1, 0DC1, N0S2; 199. DU0XA2, LUCAT1, CCL4, MMP1, IL6, ITPRLP; 200. DU0XA2, LUCAT1, CCL4, MMP1, IL6, N0S2; 201. DU0XA2, LUCAT1, CCL4, MMP1, ITPRLP, N0S2; 202. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12; 203. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, SELE; 204. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, HCAR3; 205. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, 0DC1; 206. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, IL6; 207. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, ITPRLP; 208. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, N0S2; 209. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, SELE; 210. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, HCAR3; 211. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, 0DC1; 212. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, IL6; 213. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, ITPRLP; 214. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, N0S2; 215. DU0XA2, LUCAT1, CCL4, MMP2, SELE, HCAR3; 216. DU0XA2, LUCAT1, CCL4, MMP2, SELE, 0DC1; 217. DU0XA2, LUCAT1, CCL4, MMP2, SELE, IL6; 218. DU0XA2, LUCAT1, CCL4, MMP2, SELE, ITPRLP; 219. DU0XA2, LUCAT1, CCL4, MMP2, SELE, N0S2; 220. DU0XA2, LUCAT1, CCL4, MMP2, HCAR3, 0DC1; 221. DU0XA2, LUCAT1, CCL4, MMP2, HCAR3, IL6; 222. DU0XA2, LUCAT1, CCL4, MMP2, HCAR3, ITPRLP; 223. DU0XA2, LUCAT1, CCL4, MMP2, HCAR3, N0S2; 224. DU0XA2, LUCAT1, CCL4, MMP2, 0DC1, IL6; 225. DU0XA2, LUCAT1, CCL4, MMP2, 0DC1, ITPRLP; 226. DU0XA2, LUCAT1, CCL4, MMP2, 0DC1, N0S2; 227. DU0XA2, LUCAT1, CCL4, MMP2, IL6, ITPRLP; 228. DU0XA2, LUCAT1, CCL4, MMP2, IL6, N0S2; 229. DU0XA2, LUCAT1, CCL4, MMP2, ITPRLP, N0S2; 230. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, SELE; 231. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, HCAR3; 232. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, 0DC1; 233. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, IL6; 234. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, ITPRLP; 235. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, N0S2; 236. DU0XA2, LUCAT1, CCL4, CSF3, SELE, HCAR3; 237. DU0XA2, LUCAT1, CCL4, CSF3, SELE, 0DC1; 238. DU0XA2, LUCAT1, CCL4, CSF3, SELE, IL6; 239. DU0XA2, LUCAT1, CCL4, CSF3, SELE, ITPRLP; 240. DU0XA2, LUCAT1, CCL4, CSF3, SELE, N0S2; 241. DU0XA2, LUCAT1, CCL4, CSF3, HCAR3, 0DC1; 242. DU0XA2, LUCAT1, CCL4, CSF3, HCAR3, IL6; 243. DU0XA2, LUCAT1, CCL4, CSF3, HCAR3, ITPRLP; 244. DU0XA2, LUCAT1, CCL4, CSF3, HCAR3, N0S2; 245. DU0XA2, LUCAT1, CCL4, CSF3, 0DC1, IL6; 246. DU0XA2, LUCAT1, CCL4, CSF3, 0DC1, ITPRLP; 247. DU0XA2, LUCAT1, CCL4, CSF3, 0DC1, N0S2; 248. DU0XA2, LUCAT1, CCL4, CSF3, IL6, ITPRLP; 249. DU0XA2, LUCAT1, CCL4, CSF3, IL6, N0S2; 250. DU0XA2, LUCAT1, CCL4,

[0165] 24

[0166] 4935-6038-7201 , v. 2 CSF3, ITPRLP, NOS2; 251. DU0XA2, LUCAT1, CCL4, S100A12, SELE, HCAR3; 252. DU0XA2, LUCAT1, CCL4, S100A12, SELE, ODC1; 253. DU0XA2, LUCAT1, CCL4, S100A12, SELE, IL6; 254. DU0XA2, LUCAT1, CCL4, S100A12, SELE, ITPRLP; 255. DU0XA2, LUCAT1, CCL4, S100A12, SELE, N0S2; 256. DU0XA2, LUCAT1, CCL4, S100A12, HCAR3, 0DC1; 257. DU0XA2, LUCAT1, CCL4, S100A12, HCAR3, IL6; 258. DU0XA2, LUCAT1, CCL4, S100A12, HCAR3, ITPRLP; 259. DU0XA2, LUCAT1, CCL4, S100A12, HCAR3, N0S2; 260. DU0XA2, LUCAT1, CCL4, S100A12, 0DC1, IL6; 261. DU0XA2, LUCAT1, CCL4, S100A12, 0DC1, ITPRLP; 262. DU0XA2, LUCAT1, CCL4, S100A12, 0DC1, N0S2; 263. DU0XA2, LUCAT1, CCL4, S100A12, IL6, ITPRLP; 264. DU0XA2, LUCAT1, CCL4, S100A12, IL6, N0S2; 265. DU0XA2, LUCAT1, CCL4, S100A12, ITPRLP, N0S2; 266. DU0XA2, LUCAT1, CCL4, SELE, HCAR3, 0DC1; 267. DU0XA2, LUCAT1, CCL4, SELE, HCAR3, IL6; 268. DU0XA2, LUCAT1, CCL4, SELE, HCAR3, ITPRLP; 269. DU0XA2, LUCAT1, CCL4, SELE, HCAR3, N0S2; 270. DU0XA2, LUCAT1, CCL4, SELE, 0DC1, IL6; 271. DU0XA2, LUCAT1, CCL4, SELE, 0DC1, ITPRLP; 272. DU0XA2, LUCAT1, CCL4, SELE, 0DC1, N0S2; 273. DU0XA2, LUCAT1, CCL4, SELE, IL6, ITPRLP; 274. DU0XA2, LUCAT1, CCL4, SELE, IL6, N0S2; 275. DU0XA2, LUCAT1, CCL4, SELE, ITPRLP, N0S2; 276. DU0XA2, LUCAT1, CCL4, HCAR3, 0DC1, IL6; 277. DU0XA2, LUCAT1, CCL4, HCAR3, 0DC1, ITPRLP; 278. DU0XA2, LUCAT1, CCL4, HCAR3, 0DC1, N0S2; 279. DU0XA2, LUCAT1, CCL4, HCAR3, IL6, ITPRLP; 280. DU0XA2, LUCAT1, CCL4, HCAR3, IL6, N0S2; 281. DU0XA2, LUCAT1, CCL4, HCAR3, ITPRLP, N0S2; 282. DU0XA2, LUCAT1, CCL4, 0DC1, IL6, ITPRLP; 283. DU0XA2, LUCAT1, CCL4, 0DC1, IL6, N0S2; 284. DU0XA2, LUCAT1, CCL4, 0DC1, ITPRLP, N0S2; 285. DU0XA2, LUCAT1, CCL4, IL6, ITPRLP, N0S2; 286. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12; 287. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, SELE; 288. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, HCAR3; 289. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, 0DC1; 290. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, IL6; 291. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, ITPRLP; 292. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, N0S2; 293. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, SELE; 294. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, HCAR3; 295. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, 0DC1; 296. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, IL6; 297. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, ITPRLP; 298. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, N0S2; 299. DU0XA2, LUCAT1, MMP1, MMP2, SELE, HCAR3; 300. DU0XA2, LUCAT1, MMP1, MMP2, SELE, 0DC1; 301. DU0XA2, LUCAT1, MMP1, MMP2, SELE, IL6; 302. DU0XA2, LUCAT1, MMP1, MMP2, SELE, ITPRLP; 303. DU0XA2, LUCAT1, MMP1, MMP2, SELE, N0S2; 304. DU0XA2, LUCAT1, MMP1, MMP2, HCAR3, 0DC1; 305. DU0XA2, LUCAT1, MMP1, MMP2, HCAR3, IL6; 306. DU0XA2, LUCAT1, MMP1, MMP2, HCAR3, ITPRLP; 307. DU0XA2, LUCAT1, MMP1, MMP2, HCAR3, N0S2; 308. DU0XA2, LUCAT1, MMP1, MMP2, 0DC1, IL6; 309. DU0XA2, LUCAT1, MMP1, MMP2, 0DC1, ITPRLP; 310. DU0XA2, LUCAT1, MMP1, MMP2, 0DC1, N0S2; 311.

[0167] DU0XA2, LUCAT1, MMP1, MMP2, IL6, ITPRLP; 312. DU0XA2, LUCAT1, MMP1, MMP2, IL6, N0S2; 313. DU0XA2, LUCAT1, MMP1, MMP2, ITPRLP, N0S2; 314. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, SELE; 315. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, HCAR3; 316. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, 0DC1; 317. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, IL6; 318. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, ITPRLP; 319. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, N0S2; 320. DU0XA2, LUCAT1, MMP1, CSF3, SELE, HCAR3; 321. DU0XA2, LUCAT1, MMP1, CSF3, SELE, 0DC1; 322. DU0XA2, LUCAT1, MMP1, CSF3, SELE, IL6; 323. DU0XA2, LUCAT1, MMP1, CSF3, SELE, ITPRLP; 324. DU0XA2, LUCAT1, MMP1, CSF3, SELE, N0S2; 325. DU0XA2, LUCAT1, MMP1, CSF3, HCAR3, 0DC1; 326. DU0XA2,

[0168] 25

[0169] 4935-6038-7201 , v. 2 LUCAT1, MMP1, CSF3, HCAR3, IL6; 327. DU0XA2, LUCAT1, MMP1, CSF3, HCAR3, ITPRLP; 328. DU0XA2, LUCAT1, MMP1, CSF3, HCAR3, N0S2; 329. DU0XA2, LUCAT1, MMP1, CSF3, 0DC1, IL6; 330. DU0XA2, LUCAT1, MMP1, CSF3, 0DC1, ITPRIP; 331. DU0XA2, LUCAT1, MMP1, CSF3, 0DC1, N0S2; 332. DU0XA2, LUCAT1, MMP1, CSF3, IL6, ITPRIP; 333. DU0XA2, LUCAT1, MMP1, CSF3, IL6, N0S2; 334. DU0XA2, LUCAT1, MMP1, CSF3, ITPRIP, N0S2; 335. DU0XA2, LUCAT1, MMP1, S100A12, SELE, HCAR3; 336. DU0XA2, LUCAT1, MMP1, S100A12, SELE, 0DC1; 337. DU0XA2, LUCAT1, MMP1, S100A12, SELE, IL6; 338. DU0XA2, LUCAT1, MMP1, S100A12, SELE, ITPRLP; 339. DU0XA2, LUCAT1, MMP1, S100A12, SELE, N0S2; 340. DU0XA2, LUCAT1, MMP1, S100A12, HCAR3, 0DC1; 341. DU0XA2, LUCAT1, MMP1, S100A12, HCAR3, IL6; 342. DU0XA2, LUCAT1, MMP1, S100A12, HCAR3, ITPRLP; 343. DU0XA2, LUCAT1, MMP1, S100A12, HCAR3, N0S2; 344. DU0XA2, LUCAT1, MMP1, S100A12, 0DC1, IL6; 345. DU0XA2, LUCAT1, MMP1, S100A12, 0DC1, ITPRLP; 346. DU0XA2, LUCAT1, MMP1, S100A12, 0DC1, N0S2; 347. DU0XA2, LUCAT1, MMP1, S100A12, IL6, ITPRLP; 348. DU0XA2, LUCAT1, MMP1, S100A12, IL6, N0S2; 349. DU0XA2, LUCAT1, MMP1, S100A12, ITPRLP, N0S2; 350. DU0XA2, LUCAT1, MMP1, SELE, HCAR3, 0DC1; 351. DU0XA2, LUCAT1, MMP1, SELE, HCAR3, IL6; 352. DU0XA2, LUCAT1, MMP1, SELE, HCAR3, ITPRLP; 353. DU0XA2, LUCAT1, MMP1, SELE, HCAR3, N0S2; 354. DU0XA2, LUCAT1, MMP1, SELE, 0DC1, IL6; 355. DU0XA2, LUCAT1, MMP1, SELE, 0DC1, ITPRLP; 356. DU0XA2, LUCAT1, MMP1, SELE, 0DC1, N0S2; 357. DU0XA2, LUCAT1, MMP1, SELE, IL6, ITPRLP; 358. DU0XA2, LUCAT1, MMP1, SELE, IL6, N0S2; 359. DU0XA2, LUCAT1, MMP1, SELE, ITPRLP, N0S2; 360. DU0XA2, LUCAT1, MMP1, HCAR3, 0DC1, IL6; 361. DU0XA2, LUCAT1, MMP1, HCAR3, 0DC1, ITPRLP; 362. DU0XA2, LUCAT1, MMP1, HCAR3, 0DC1, N0S2; 363. DU0XA2, LUCAT1, MMP1, HCAR3, IL6, ITPRLP; 364. DU0XA2, LUCAT1, MMP1, HCAR3, IL6, N0S2; 365. DU0XA2, LUCAT1, MMP1, HCAR3, ITPRLP, N0S2; 366. DU0XA2, LUCAT1, MMP1, 0DC1, IL6, ITPRLP; 367. DU0XA2, LUCAT1, MMP1, 0DC1, IL6, N0S2; 368. DU0XA2, LUCAT1, MMP1, 0DC1, ITPRLP, N0S2; 369. DU0XA2, LUCAT1, MMP1, IL6, ITPRLP, N0S2; 370. DU0XA2, LUCAT1, MMP2, CSF3, S100A12, SELE; 371. DU0XA2, LUCAT1, MMP2, CSF3, S100A12, HCAR3; 372. DU0XA2, LUCAT1, MMP2, CSF3, S100A12, 0DC1; 373. DU0XA2, LUCAT1, MMP2, CSF3, S100A12, IL6; 374. DU0XA2, LUCAT1, MMP2, CSF3, S100A12, ITPRLP; 375.

[0170] DU0XA2, LUCAT1, MMP2, CSF3, S100A12, N0S2; 376. DU0XA2, LUCAT1, MMP2, CSF3, SELE, HCAR3; 377. DU0XA2, LUCAT1, MMP2, CSF3, SELE, 0DC1; 378. DU0XA2, LUCAT1, MMP2, CSF3, SELE, IL6; 379. DU0XA2, LUCAT1, MMP2, CSF3, SELE, ITPRLP; 380. DU0XA2, LUCAT1, MMP2, CSF3, SELE, N0S2; 381. DU0XA2, LUCAT1, MMP2, CSF3, HCAR3, 0DC1; 382. DU0XA2, LUCAT1, MMP2, CSF3, HCAR3, IL6; 383. DU0XA2, LUCAT1, MMP2, CSF3, HCAR3, ITPRLP; 384. DU0XA2, LUCAT1, MMP2, CSF3, HCAR3, N0S2; 385. DU0XA2, LUCAT1, MMP2, CSF3, 0DC1, IL6; 386. DU0XA2, LUCAT1, MMP2, CSF3, 0DC1, ITPRLP; 387. DU0XA2, LUCAT1, MMP2, CSF3, 0DC1, N0S2; 388. DU0XA2, LUCAT1, MMP2, CSF3, IL6, ITPRLP; 389. DU0XA2, LUCAT1, MMP2, CSF3, IL6, N0S2; 390. DU0XA2, LUCAT1, MMP2, CSF3, ITPRLP, N0S2; 391. DU0XA2, LUCAT1, MMP2, S100A12, SELE, HCAR3; 392. DU0XA2, LUCAT1, MMP2, S100A12, SELE, 0DC1; 393. DU0XA2, LUCAT1, MMP2, S100A12, SELE, IL6; 394. DU0XA2, LUCAT1, MMP2, S100A12, SELE, ITPRLP; 395. DU0XA2, LUCAT1, MMP2, S100A12, SELE, N0S2; 396. DU0XA2, LUCAT1, MMP2, S100A12, HCAR3, 0DC1; 397. DU0XA2, LUCAT1, MMP2, S100A12, HCAR3, IL6; 398. DU0XA2, LUCAT1, MMP2, S100A12, HCAR3, ITPRLP; 399. DU0XA2, LUCAT1, MMP2, S100A12, HCAR3, N0S2; 400. DU0XA2, LUCAT1, MMP2, S100A12, 0DC1, IL6; 401. DU0XA2, LUCAT1, MMP2,

[0171] 26

[0172] 4935-6038-7201 , v. 2 S100A12, 0DC1, ITPRLP; 402. DU0XA2, LUCAT1, MMP2, S100A12, 0DC1, NOS2; 403. DU0XA2, LUCAT1, MMP2, S100A12, IL6, ITPRIP; 404. DU0XA2, LUCAT1, MMP2, S100A12, IL6, N0S2; 405. DU0XA2, LUCAT1, MMP2, S100A12, ITPRIP, N0S2; 406. DU0XA2, LUCAT1, MMP2, SELE, HCAR3, ODC1; 407.

[0173] 995 DU0XA2, LUCAT1, MMP2, SELE, HCAR3, IL6; 408. DU0XA2, LUCAT1, MMP2, SELE, HCAR3, ITPRLP; 409. DU0XA2, LUCAT1, MMP2, SELE, HCAR3, N0S2; 410. DU0XA2, LUCAT1, MMP2, SELE, 0DC1, IL6; 411. DU0XA2, LUCAT1, MMP2, SELE, 0DC1, ITPRLP; 412. DU0XA2, LUCAT1, MMP2, SELE, 0DC1, N0S2; 413. DU0XA2, LUCAT1, MMP2, SELE, IL6, ITPRLP; 414. DU0XA2, LUCAT1, MMP2, SELE, IL6, N0S2; 415. DU0XA2, LUCAT1, MMP2, SELE, ITPRLP, N0S2; 416. DU0XA2, LUCAT1, MMP2, HCAR3,

[0174] 1000 0DC1, IL6; 417. DU0XA2, LUCAT1, MMP2, HCAR3, 0DC1, ITPRLP; 418. DU0XA2, LUCAT1, MMP2, HCAR3, 0DC1, N0S2; 419. DU0XA2, LUCAT1, MMP2, HCAR3, IL6, ITPRLP; 420. DU0XA2, LUCAT1, MMP2, HCAR3, IL6, N0S2; 421. DU0XA2, LUCAT1, MMP2, HCAR3, ITPRLP, N0S2; 422. DU0XA2, LUCAT1, MMP2, 0DC1, IL6, ITPRLP; 423. DU0XA2, LUCAT1, MMP2, 0DC1, IL6, N0S2; 424. DU0XA2, LUCAT1, MMP2, 0DC1, ITPRLP, N0S2; 425. DU0XA2, LUCAT1, MMP2, IL6, ITPRLP, N0S2; 426.

[0175] 1005 DU0XA2, LUCAT1, CSF3, S100A12, SELE, HCAR3; 427. DU0XA2, LUCAT1, CSF3, S100A12, SELE, 0DC1; 428. DU0XA2, LUCAT1, CSF3, S100A12, SELE, IL6; 429. DU0XA2, LUCAT1, CSF3, S100A12, SELE, ITPRLP; 430. DU0XA2, LUCAT1, CSF3, S100A12, SELE, N0S2; 431. DU0XA2, LUCAT1, CSF3, S100A12, HCAR3, 0DC1; 432. DU0XA2, LUCAT1, CSF3, S100A12, HCAR3, IL6; 433. DU0XA2, LUCAT1, CSF3, S100A12, HCAR3, ITPRLP; 434. DU0XA2, LUCAT1, CSF3, S100A12, HCAR3, N0S2; 435. DU0XA2,

[0176] 1010 LUCAT1, CSF3, S100A12, 0DC1, IL6; 436. DU0XA2, LUCAT1, CSF3, S100A12, 0DC1, ITPRLP; 437. DU0XA2, LUCAT1, CSF3, S100A12, 0DC1, N0S2; 438. DU0XA2, LUCAT1, CSF3, S100A12, IL6, ITPRLP; 439. DU0XA2, LUCAT1, CSF3, S100A12, IL6, N0S2; 440. DU0XA2, LUCAT1, CSF3, S100A12, ITPRLP, N0S2; 441. DU0XA2, LUCAT1, CSF3, SELE, HCAR3, 0DC1; 442. DU0XA2, LUCAT1, CSF3, SELE, HCAR3, IL6; 443. DU0XA2, LUCAT1, CSF3, SELE, HCAR3, ITPRLP; 444. DU0XA2, LUCAT1, CSF3, SELE,

[0177] 1015 HCAR3, N0S2; 445. DU0XA2, LUCAT1, CSF3, SELE, 0DC1, IL6; 446. DU0XA2, LUCAT1, CSF3, SELE, 0DC1, ITPRLP; 447. DU0XA2, LUCAT1, CSF3, SELE, 0DC1, N0S2; 448. DU0XA2, LUCAT1, CSF3, SELE, IL6, ITPRLP; 449. DU0XA2, LUCAT1, CSF3, SELE, IL6, N0S2; 450. DU0XA2, LUCAT1, CSF3, SELE, ITPRLP, N0S2; 451. DU0XA2, LUCAT1, CSF3, HCAR3, 0DC1, IL6; 452. DU0XA2, LUCAT1, CSF3, HCAR3, 0DC1, ITPRLP; 453. DU0XA2, LUCAT1, CSF3, HCAR3, 0DC1, N0S2; 454. DU0XA2, LUCAT1,

[0178] 1020 CSF3, HCAR3, IL6, ITPRLP; 455. DU0XA2, LUCAT1, CSF3, HCAR3, IL6, N0S2; 456. DU0XA2, LUCAT1, CSF3, HCAR3, ITPRLP, N0S2; 457. DU0XA2, LUCAT1, CSF3, 0DC1, IL6, ITPRLP; 458. DU0XA2, LUCAT1, CSF3, 0DC1, IL6, N0S2; 459. DU0XA2, LUCAT1, CSF3, 0DC1, ITPRLP, N0S2; 460. DU0XA2, LUCAT1, CSF3, IL6, ITPRLP, N0S2; 461. DU0XA2, LUCAT1, S100A12, SELE, HCAR3, 0DC1; 462. DU0XA2, LUCAT1, S100A12, SELE, HCAR3, IL6; 463. DU0XA2, LUCAT1, S100A12, SELE, HCAR3, ITPRLP; 464.

[0179] 1025 DU0XA2, LUCAT1, S100A12, SELE, HCAR3, N0S2; 465. DU0XA2, LUCAT1, S100A12, SELE, 0DC1, IL6; 466. DU0XA2, LUCAT1, S100A12, SELE, 0DC1, ITPRLP; 467. DU0XA2, LUCAT1, S100A12, SELE, 0DC1, N0S2; 468. DU0XA2, LUCAT1, S100A12, SELE, IL6, ITPRLP; 469. DU0XA2, LUCAT1, S100A12, SELE, IL6, N0S2; 470. DU0XA2, LUCAT1, S100A12, SELE, ITPRLP, N0S2; 471. DU0XA2, LUCAT1, S100A12, HCAR3, 0DC1, IL6; 472. DU0XA2, LUCAT1, S100A12, HCAR3, 0DC1, ITPRLP; 473. DU0XA2, LUCAT1, S100A12,

[0180] 1030 HCAR3, 0DC1, N0S2; 474. DU0XA2, LUCAT1, S100A12, HCAR3, IL6, ITPRLP; 475. DU0XA2, LUCAT1, S100A12, HCAR3, IL6, N0S2; 476. DU0XA2, LUCAT1, S100A12, HCAR3, ITPRLP, N0S2; 477. DU0XA2,

[0181] 27

[0182] 4935-6038-7201 , v. 2 LUCAT1, S100A12, 0DC1, IL6, ITPRLP; 478. DU0XA2, LUCAT1, S100A12, 0DC1, IL6, NOS2; 479. DU0XA2, LUCAT1, S100A12, 0DC1, ITPRIP, N0S2; 480. DU0XA2, LUCAT1, S100A12, IL6, ITPRIP, N0S2; 481. DU0XA2, LUCAT1, SELE, HCAR3, 0DC1, IL6; 482. DU0XA2, LUCAT1, SELE, HCAR3, 0DC1,

[0183] 1035 ITPRIP; 483. DU0XA2, LUCAT1, SELE, HCAR3, 0DC1, N0S2; 484. DU0XA2, LUCAT1, SELE, HCAR3, IL6, ITPRIP; 485. DU0XA2, LUCAT1, SELE, HCAR3, IL6, N0S2; 486. DU0XA2, LUCAT1, SELE, HCAR3, ITPRIP, N0S2; 487. DU0XA2, LUCAT1, SELE, 0DC1, IL6, ITPRLP; 488. DU0XA2, LUCAT1, SELE, 0DC1, IL6, N0S2; 489. DU0XA2, LUCAT1, SELE, 0DC1, ITPRLP, N0S2; 490. DU0XA2, LUCAT1, SELE, IL6, ITPRLP, N0S2; 491. DU0XA2, LUCAT1, HCAR3, 0DC1, IL6, ITPRLP; 492. DU0XA2, LUCAT1, HCAR3,

[0184] 1040 0DC1, IL6, N0S2; 493. DU0XA2, LUCAT1, HCAR3, 0DC1, ITPRLP, N0S2; 494. DU0XA2, LUCAT1, HCAR3, IL6, ITPRLP, N0S2; 495. DU0XA2, LUCAT1, 0DC1, IL6, ITPRLP, N0S2; 496. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3; 497. DU0XA2, CXCR1, CCL4, MMP1, MMP2, S100A12; 498. DU0XA2, CXCR1, CCL4, MMP1, MMP2, SELE; 499. DU0XA2, CXCR1, CCL4, MMP1, MMP2, HCAR3; 500. DU0XA2, CXCR1, CCL4, MMP1, MMP2, 0DC1; 501. DU0XA2, CXCR1, CCL4, MMP1, MMP2, IL6; 502. DU0XA2,

[0185] 1045 CXCR1, CCL4, MMP1, MMP2, ITPRLP; 503. DU0XA2, CXCR1, CCL4, MMP1, MMP2, N0S2; 504.

[0186] DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12; 505. DU0XA2, CXCR1, CCL4, MMP1, CSF3, SELE; 506. DU0XA2, CXCR1, CCL4, MMP1, CSF3, HCAR3; 507. DU0XA2, CXCR1, CCL4, MMP1, CSF3, 0DC1; 508. DU0XA2, CXCR1, CCL4, MMP1, CSF3, IL6; 509. DU0XA2, CXCR1, CCL4, MMP1, CSF3, ITPRLP; 510. DU0XA2, CXCR1, CCL4, MMP1, CSF3, N0S2; 511. DU0XA2, CXCR1, CCL4, MMP1, S100A12, SELE; 512.

[0187] 1050 DU0XA2, CXCR1, CCL4, MMP1, S100A12, HCAR3; 513. DU0XA2, CXCR1, CCL4, MMP1, S100A12, 0DC1; 514. DU0XA2, CXCR1, CCL4, MMP1, S100A12, IL6; 515. DU0XA2, CXCR1, CCL4, MMP1, S100A12, ITPRLP; 516. DU0XA2, CXCR1, CCL4, MMP1, S100A12, N0S2; 517. DU0XA2, CXCR1, CCL4, MMP1, SELE, HCAR3; 518. DU0XA2, CXCR1, CCL4, MMP1, SELE, 0DC1; 519. DU0XA2, CXCR1, CCL4, MMP1, SELE, IL6; 520. DU0XA2, CXCR1, CCL4, MMP1, SELE, ITPRLP; 521. DU0XA2, CXCR1, CCL4, MMP1,

[0188] 1055 SELE, N0S2; 522. DU0XA2, CXCR1, CCL4, MMP1, HCAR3, 0DC1; 523. DU0XA2, CXCR1, CCL4, MMP1, HCAR3, IL6; 524. DU0XA2, CXCR1, CCL4, MMP1, HCAR3, ITPRLP; 525. DU0XA2, CXCR1, CCL4, MMP1, HCAR3, N0S2; 526. DU0XA2, CXCR1, CCL4, MMP1, 0DC1, IL6; 527. DU0XA2, CXCR1, CCL4, MMP1, 0DC1, ITPRLP; 528. DU0XA2, CXCR1, CCL4, MMP1, 0DC1, N0S2; 529. DU0XA2, CXCR1, CCL4, MMP1, IL6, ITPRLP; 530. DU0XA2, CXCR1, CCL4, MMP1, IL6, N0S2; 531. DU0XA2, CXCR1, CCL4, MMP1,

[0189] 1060 ITPRLP, N0S2; 532. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12; 533. DU0XA2, CXCR1, CCL4, MMP2, CSF3, SELE; 534. DU0XA2, CXCR1, CCL4, MMP2, CSF3, HCAR3; 535. DU0XA2, CXCR1, CCL4, MMP2, CSF3, 0DC1; 536. DU0XA2, CXCR1, CCL4, MMP2, CSF3, IL6; 537. DU0XA2, CXCR1, CCL4, MMP2, CSF3, ITPRLP; 538. DU0XA2, CXCR1, CCL4, MMP2, CSF3, N0S2; 539. DU0XA2, CXCR1, CCL4, MMP2, S100A12, SELE; 540. DU0XA2, CXCR1, CCL4, MMP2, S100A12, HCAR3; 541. DU0XA2, CXCR1,

[0190] 1065 CCL4, MMP2, S100A12, 0DC1; 542. DU0XA2, CXCR1, CCL4, MMP2, S100A12, IL6; 543. DU0XA2, CXCR1, CCL4, MMP2, S100A12, ITPRLP; 544. DU0XA2, CXCR1, CCL4, MMP2, S100A12, N0S2; 545. DU0XA2, CXCR1, CCL4, MMP2, SELE, HCAR3; 546. DU0XA2, CXCR1, CCL4, MMP2, SELE, 0DC1; 547. DU0XA2, CXCR1, CCL4, MMP2, SELE, IL6; 548. DU0XA2, CXCR1, CCL4, MMP2, SELE, ITPRLP; 549.

[0191] DU0XA2, CXCR1, CCL4, MMP2, SELE, N0S2; 550. DU0XA2, CXCR1, CCL4, MMP2, HCAR3, 0DC1; 551.

[0192] 1070 DU0XA2, CXCR1, CCL4, MMP2, HCAR3, IL6; 552. DU0XA2, CXCR1, CCL4, MMP2, HCAR3, ITPRLP; 553. DU0XA2, CXCR1, CCL4, MMP2, HCAR3, N0S2; 554. DU0XA2, CXCR1, CCL4, MMP2, 0DC1, IL6; 555.

[0193] 28

[0194] 4935-6038-7201 , v. 2 DU0XA2, CXCR1, CCL4, MMP2, 0DC1, ITPRLP; 556. DU0XA2, CXCR1, CCL4, MMP2, 0DC1, NOS2; 557. DU0XA2, CXCR1, CCL4, MMP2, IL6, ITPRIP; 558. DU0XA2, CXCR1, CCL4, MMP2, IL6, N0S2; 559. DU0XA2, CXCR1, CCL4, MMP2, ITPRIP, N0S2; 560. DU0XA2, CXCR1, CCL4, CSF3, S100A12, SELE; 561.

[0195] 1075 DU0XA2, CXCR1, CCL4, CSF3, S100A12, HCAR3; 562. DU0XA2, CXCR1, CCL4, CSF3, S100A12, ODC1; 563. DU0XA2, CXCR1, CCL4, CSF3, S100A12, IL6; 564. DU0XA2, CXCR1, CCL4, CSF3, S100A12, ITPRIP; 565. DU0XA2, CXCR1, CCL4, CSF3, S100A12, N0S2; 566. DU0XA2, CXCR1, CCL4, CSF3, SELE, HCAR3; 567. DU0XA2, CXCR1, CCL4, CSF3, SELE, 0DC1; 568. DU0XA2, CXCR1, CCL4, CSF3, SELE, IL6; 569. DU0XA2, CXCR1, CCL4, CSF3, SELE, ITPRLP; 570. DU0XA2, CXCR1, CCL4, CSF3, SELE, N0S2; 571.

[0196] 1080 DU0XA2, CXCR1, CCL4, CSF3, HCAR3, 0DC1; 572. DU0XA2, CXCR1, CCL4, CSF3, HCAR3, IL6; 573. DU0XA2, CXCR1, CCL4, CSF3, HCAR3, ITPRLP; 574. DU0XA2, CXCR1, CCL4, CSF3, HCAR3, N0S2; 575. DU0XA2, CXCR1, CCL4, CSF3, 0DC1, IL6; 576. DU0XA2, CXCR1, CCL4, CSF3, 0DC1, ITPRLP; 577. DU0XA2, CXCR1, CCL4, CSF3, 0DC1, N0S2; 578. DU0XA2, CXCR1, CCL4, CSF3, IL6, ITPRLP; 579. DU0XA2, CXCR1, CCL4, CSF3, IL6, N0S2; 580. DU0XA2, CXCR1, CCL4, CSF3, ITPRLP, N0S2; 581.

[0197] 1085 DU0XA2, CXCR1, CCL4, S100A12, SELE, HCAR3; 582. DU0XA2, CXCR1, CCL4, S100A12, SELE, 0DC1; 583. DU0XA2, CXCR1, CCL4, S100A12, SELE, IL6; 584. DU0XA2, CXCR1, CCL4, S100A12, SELE, ITPRLP; 585. DU0XA2, CXCR1, CCL4, S100A12, SELE, N0S2; 586. DU0XA2, CXCR1, CCL4, S100A12, HCAR3, 0DC1; 587. DU0XA2, CXCR1, CCL4, S100A12, HCAR3, IL6; 588. DU0XA2, CXCR1, CCL4, S100A12, HCAR3, ITPRLP; 589. DU0XA2, CXCR1, CCL4, S100A12, HCAR3, N0S2; 590. DU0XA2, CXCR1, CCL4,

[0198] 1090 S100A12, 0DC1, IL6; 591. DU0XA2, CXCR1, CCL4, S100A12, 0DC1, ITPRLP; 592. DU0XA2, CXCR1, CCL4, S100A12, 0DC1, N0S2; 593. DU0XA2, CXCR1, CCL4, S100A12, IL6, ITPRLP; 594. DU0XA2, CXCR1, CCL4, S100A12, IL6, N0S2; 595. DU0XA2, CXCR1, CCL4, S100A12, ITPRLP, N0S2; 596. DU0XA2, CXCR1, CCL4, SELE, HCAR3, 0DC1; 597. DU0XA2, CXCR1, CCL4, SELE, HCAR3, IL6; 598. DU0XA2, CXCR1, CCL4, SELE, HCAR3, ITPRLP; 599. DU0XA2, CXCR1, CCL4, SELE, HCAR3, N0S2; 600. DU0XA2,

[0199] 1095 CXCR1, CCL4, SELE, 0DC1, IL6; 601. DU0XA2, CXCR1, CCL4, SELE, 0DC1, ITPRLP; 602. DU0XA2, CXCR1, CCL4, SELE, 0DC1, N0S2; 603. DU0XA2, CXCR1, CCL4, SELE, IL6, ITPRLP; 604. DU0XA2, CXCR1, CCL4, SELE, IL6, N0S2; 605. DU0XA2, CXCR1, CCL4, SELE, ITPRLP, N0S2; 606. DU0XA2, CXCR1, CCL4, HCAR3, 0DC1, IL6; 607. DU0XA2, CXCR1, CCL4, HCAR3, 0DC1, ITPRLP; 608. DU0XA2, CXCR1, CCL4, HCAR3, 0DC1, N0S2; 609. DU0XA2, CXCR1, CCL4, HCAR3, IL6, ITPRLP; 610. DU0XA2,

[0200] 1100 CXCR1, CCL4, HCAR3, IL6, N0S2; 611. DU0XA2, CXCR1, CCL4, HCAR3, ITPRLP, N0S2; 612. DU0XA2, CXCR1, CCL4, 0DC1, IL6, ITPRLP; 613. DU0XA2, CXCR1, CCL4, 0DC1, IL6, N0S2; 614. DU0XA2, CXCR1, CCL4, 0DC1, ITPRLP, N0S2; 615. DU0XA2, CXCR1, CCL4, IL6, ITPRLP, N0S2; 616. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12; 617. DU0XA2, CXCR1, MMP1, MMP2, CSF3, SELE; 618.

[0201] DU0XA2, CXCR1, MMP1, MMP2, CSF3, HCAR3; 619. DU0XA2, CXCR1, MMP1, MMP2, CSF3, 0DC1;

[0202] 1105 620. DU0XA2, CXCR1, MMP1, MMP2, CSF3, IL6; 621. DU0XA2, CXCR1, MMP1, MMP2, CSF3, ITPRLP; 622. DU0XA2, CXCR1, MMP1, MMP2, CSF3, N0S2; 623. DU0XA2, CXCR1, MMP1, MMP2, S100A12, SELE; 624. DU0XA2, CXCR1, MMP1, MMP2, S100A12, HCAR3; 625. DU0XA2, CXCR1, MMP1, MMP2, S100A12, 0DC1; 626. DU0XA2, CXCR1, MMP1, MMP2, S100A12, IL6; 627. DU0XA2, CXCR1, MMP1, MMP2, S100A12, ITPRLP; 628. DU0XA2, CXCR1, MMP1, MMP2, S100A12, N0S2; 629. DU0XA2, CXCR1,

[0203] 1110 MMP1, MMP2, SELE, HCAR3; 630. DU0XA2, CXCR1, MMP1, MMP2, SELE, 0DC1; 631. DU0XA2, CXCR1, MMP1, MMP2, SELE, IL6; 632. DU0XA2, CXCR1, MMP1, MMP2, SELE, ITPRLP; 633. DU0XA2,

[0204] 29

[0205] 4935-6038-7201 , v. 2 CXCR1, MMP1, MMP2, SELE, NOS2; 634. DU0XA2, CXCR1, MMP1, MMP2, HCAR3, ODC1; 635. DU0XA2, CXCR1, MMP1, MMP2, HCAR3, IL6; 636. DU0XA2, CXCR1, MMP1, MMP2, HCAR3, ITPRIP; 637. DU0XA2, CXCR1, MMP1, MMP2, HCAR3, N0S2; 638. DU0XA2, CXCR1, MMP1, MMP2, 0DC1, IL6;

[0206] 1115 639. DU0XA2, CXCR1, MMP1, MMP2, 0DC1, ITPRIP; 640. DU0XA2, CXCR1, MMP1, MMP2, 0DC1, N0S2; 641. DU0XA2, CXCR1, MMP1, MMP2, IL6, ITPRIP; 642. DU0XA2, CXCR1, MMP1, MMP2, IL6, N0S2; 643. DU0XA2, CXCR1, MMP1, MMP2, ITPRIP, N0S2; 644. DU0XA2, CXCR1, MMP1, CSF3, S100A12, SELE; 645. DU0XA2, CXCR1, MMP1, CSF3, S100A12, HCAR3; 646. DU0XA2, CXCR1, MMP1, CSF3, S100A12, 0DC1; 647. DU0XA2, CXCR1, MMP1, CSF3, S100A12, IL6; 648. DU0XA2, CXCR1,

[0207] 1120 MMP1, CSF3, S100A12, ITPRIP; 649. DU0XA2, CXCR1, MMP1, CSF3, S100A12, N0S2; 650. DU0XA2, CXCR1, MMP1, CSF3, SELE, HCAR3; 651. DU0XA2, CXCR1, MMP1, CSF3, SELE, 0DC1; 652. DU0XA2, CXCR1, MMP1, CSF3, SELE, IL6; 653. DU0XA2, CXCR1, MMP1, CSF3, SELE, ITPRLP; 654. DU0XA2, CXCR1, MMP1, CSF3, SELE, N0S2; 655. DU0XA2, CXCR1, MMP1, CSF3, HCAR3, 0DC1; 656. DU0XA2, CXCR1, MMP1, CSF3, HCAR3, IL6; 657. DU0XA2, CXCR1, MMP1, CSF3, HCAR3, ITPRLP; 658. DU0XA2,

[0208] 1125 CXCR1, MMP1, CSF3, HCAR3, N0S2; 659. DU0XA2, CXCR1, MMP1, CSF3, 0DC1, IL6; 660. DU0XA2, CXCR1, MMP1, CSF3, 0DC1, ITPRLP; 661. DU0XA2, CXCR1, MMP1, CSF3, 0DC1, N0S2; 662. DU0XA2, CXCR1, MMP1, CSF3, IL6, ITPRLP; 663. DU0XA2, CXCR1, MMP1, CSF3, IL6, N0S2; 664. DU0XA2, CXCR1, MMP1, CSF3, ITPRLP, N0S2; 665. DU0XA2, CXCR1, MMP1, S100A12, SELE, HCAR3; 666. DU0XA2, CXCR1, MMP1, S100A12, SELE, 0DC1; 667. DU0XA2, CXCR1, MMP1, S100A12, SELE, IL6;

[0209] 1130 668. DU0XA2, CXCR1, MMP1, S100A12, SELE, ITPRLP; 669. DU0XA2, CXCR1, MMP1, S100A12, SELE, N0S2; 670. DU0XA2, CXCR1, MMP1, S100A12, HCAR3, 0DC1; 671. DU0XA2, CXCR1, MMP1, S100A12, HCAR3, IL6; 672. DU0XA2, CXCR1, MMP1, S100A12, HCAR3, ITPRLP; 673. DU0XA2, CXCR1, MMP1, S100A12, HCAR3, N0S2; 674. DU0XA2, CXCR1, MMP1, S100A12, 0DC1, IL6; 675. DU0XA2, CXCR1, MMP1, S100A12, 0DC1, ITPRLP; 676. DU0XA2, CXCR1, MMP1, S100A12, 0DC1, N0S2; 677. DU0XA2,

[0210] 1135 CXCR1, MMP1, S100A12, IL6, ITPRLP; 678. DU0XA2, CXCR1, MMP1, S100A12, IL6, N0S2; 679. DU0XA2, CXCR1, MMP1, S100A12, ITPRLP, N0S2; 680. DU0XA2, CXCR1, MMP1, SELE, HCAR3, 0DC1; 681. DU0XA2, CXCR1, MMP1, SELE, HCAR3, IL6; 682. DU0XA2, CXCR1, MMP1, SELE, HCAR3, ITPRLP; 683. DU0XA2, CXCR1, MMP1, SELE, HCAR3, N0S2; 684. DU0XA2, CXCR1, MMP1, SELE, 0DC1, IL6; 685. DU0XA2, CXCR1, MMP1, SELE, 0DC1, ITPRLP; 686. DU0XA2, CXCR1, MMP1, SELE, 0DC1, N0S2; 687.

[0211] 1140 DU0XA2, CXCR1, MMP1, SELE, IL6, ITPRLP; 688. DU0XA2, CXCR1, MMP1, SELE, IL6, N0S2; 689. DU0XA2, CXCR1, MMP1, SELE, ITPRLP, N0S2; 690. DU0XA2, CXCR1, MMP1, HCAR3, 0DC1, IL6; 691. DU0XA2, CXCR1, MMP1, HCAR3, 0DC1, ITPRLP; 692. DU0XA2, CXCR1, MMP1, HCAR3, 0DC1, N0S2; 693. DU0XA2, CXCR1, MMP1, HCAR3, IL6, ITPRLP; 694. DU0XA2, CXCR1, MMP1, HCAR3, IL6, N0S2; 695. DU0XA2, CXCR1, MMP1, HCAR3, ITPRLP, N0S2; 696. DU0XA2, CXCR1, MMP1, 0DC1, IL6, ITPRLP;

[0212] 1145 697. DU0XA2, CXCR1, MMP1, 0DC1, IL6, N0S2; 698. DU0XA2, CXCR1, MMP1, 0DC1, ITPRLP, N0S2; 699. DU0XA2, CXCR1, MMP1, IL6, ITPRLP, N0S2; 700. DU0XA2, CXCR1, MMP2, CSF3, S100A12, SELE; 701. DU0XA2, CXCR1, MMP2, CSF3, S100A12, HCAR3; 702. DU0XA2, CXCR1, MMP2, CSF3, S100A12, 0DC1; 703. DU0XA2, CXCR1, MMP2, CSF3, S100A12, IL6; 704. DU0XA2, CXCR1, MMP2, CSF3, S100A12, ITPRLP; 705. DU0XA2, CXCR1, MMP2, CSF3, S100A12, N0S2; 706. DU0XA2, CXCR1, MMP2,

[0213] 1150 CSF3, SELE, HCAR3; 707. DU0XA2, CXCR1, MMP2, CSF3, SELE, 0DC1; 708. DU0XA2, CXCR1, MMP2, CSF3, SELE, IL6; 709. DU0XA2, CXCR1, MMP2, CSF3, SELE, ITPRLP; 710. DU0XA2, CXCR1, MMP2,

[0214] 30

[0215] 4935-6038-7201 , v. 2 CSF3, SELE, N0S2; 711. DU0XA2, CXCR1, MMP2, CSF3, HCAR3, ODC1; 712. DU0XA2, CXCR1, MMP2, CSF3, HCAR3, IL6; 713. DU0XA2, CXCR1, MMP2, CSF3, HCAR3, ITPRIP; 714. DU0XA2, CXCR1, MMP2, CSF3, HCAR3, N0S2; 715. DU0XA2, CXCR1, MMP2, CSF3, 0DC1, IL6; 716. DU0XA2, CXCR1, MMP2,

[0216] 1155 CSF3, 0DC1, ITPRIP; 717. DU0XA2, CXCR1, MMP2, CSF3, 0DC1, N0S2; 718. DU0XA2, CXCR1, MMP2, CSF3, IL6, ITPRIP; 719. DU0XA2, CXCR1, MMP2, CSF3, IL6, N0S2; 720. DU0XA2, CXCR1, MMP2, CSF3, ITPRIP, N0S2; 721. DU0XA2, CXCR1, MMP2, S100A12, SELE, HCAR3; 722. DU0XA2, CXCR1, MMP2, S100A12, SELE, 0DC1; 723. DU0XA2, CXCR1, MMP2, S100A12, SELE, IL6; 724. DU0XA2, CXCR1, MMP2, S100A12, SELE, ITPRLP; 725. DU0XA2, CXCR1, MMP2, S100A12, SELE, N0S2; 726. DU0XA2,

[0217] 1160 CXCR1, MMP2, S100A12, HCAR3, 0DC1; 727. DU0XA2, CXCR1, MMP2, S100A12, HCAR3, IL6; 728. DU0XA2, CXCR1, MMP2, S100A12, HCAR3, ITPRLP; 729. DU0XA2, CXCR1, MMP2, S100A12, HCAR3, N0S2; 730. DU0XA2, CXCR1, MMP2, S100A12, 0DC1, IL6; 731. DU0XA2, CXCR1, MMP2, S100A12, 0DC1, ITPRLP; 732. DU0XA2, CXCR1, MMP2, S100A12, 0DC1, N0S2; 733. DU0XA2, CXCR1, MMP2, S100A12, IL6, ITPRLP; 734. DU0XA2, CXCR1, MMP2, S100A12, IL6, N0S2; 735. DU0XA2, CXCR1, MMP2,

[0218] 1165 S100A12, ITPRLP, N0S2; 736. DU0XA2, CXCR1, MMP2, SELE, HCAR3, 0DC1; 737. DU0XA2, CXCR1, MMP2, SELE, HCAR3, IL6; 738. DU0XA2, CXCR1, MMP2, SELE, HCAR3, ITPRLP; 739. DU0XA2, CXCR1, MMP2, SELE, HCAR3, N0S2; 740. DU0XA2, CXCR1, MMP2, SELE, 0DC1, IL6; 741. DU0XA2, CXCR1, MMP2, SELE, 0DC1, ITPRLP; 742. DU0XA2, CXCR1, MMP2, SELE, 0DC1, N0S2; 743. DU0XA2, CXCR1, MMP2, SELE, IL6, ITPRLP; 744. DU0XA2, CXCR1, MMP2, SELE, IL6, N0S2; 745. DU0XA2, CXCR1,

[0219] 1170 MMP2, SELE, ITPRLP, N0S2; 746. DU0XA2, CXCR1, MMP2, HCAR3, 0DC1, IL6; 747. DU0XA2, CXCR1, MMP2, HCAR3, 0DC1, ITPRLP; 748. DU0XA2, CXCR1, MMP2, HCAR3, 0DC1, N0S2; 749. DU0XA2, CXCR1, MMP2, HCAR3, IL6, ITPRLP; 750. DU0XA2, CXCR1, MMP2, HCAR3, IL6, N0S2; 751. DU0XA2, CXCR1, MMP2, HCAR3, ITPRLP, N0S2; 752. DU0XA2, CXCR1, MMP2, 0DC1, IL6, ITPRLP; 753. DU0XA2, CXCR1, MMP2, 0DC1, IL6, N0S2; 754. DU0XA2, CXCR1, MMP2, 0DC1, ITPRLP, N0S2; 755. DU0XA2,

[0220] 1175 CXCR1, MMP2, IL6, ITPRLP, N0S2; 756. DU0XA2, CXCR1, CSF3, S100A12, SELE, HCAR3; 757. DU0XA2, CXCR1, CSF3, S100A12, SELE, 0DC1; 758. DU0XA2, CXCR1, CSF3, S100A12, SELE, IL6; 759. DU0XA2, CXCR1, CSF3, S100A12, SELE, ITPRLP; 760. DU0XA2, CXCR1, CSF3, S100A12, SELE, N0S2; 761.

[0221] DU0XA2, CXCR1, CSF3, S100A12, HCAR3, 0DC1; 762. DU0XA2, CXCR1, CSF3, S100A12, HCAR3, IL6; 763. DU0XA2, CXCR1, CSF3, S100A12, HCAR3, ITPRLP; 764. DU0XA2, CXCR1, CSF3, S100A12, HCAR3,

[0222] 1180 N0S2; 765. DU0XA2, CXCR1, CSF3, S100A12, 0DC1, IL6; 766. DU0XA2, CXCR1, CSF3, S100A12, 0DC1, ITPRLP; 767. DU0XA2, CXCR1, CSF3, S100A12, 0DC1, N0S2; 768. DU0XA2, CXCR1, CSF3, S100A12, IL6, ITPRLP; 769. DU0XA2, CXCR1, CSF3, S100A12, IL6, N0S2; 770. DU0XA2, CXCR1, CSF3, S100A12, ITPRLP, N0S2; 771. DU0XA2, CXCR1, CSF3, SELE, HCAR3, 0DC1; 772. DU0XA2, CXCR1, CSF3, SELE, HCAR3, IL6; 773. DU0XA2, CXCR1, CSF3, SELE, HCAR3, ITPRLP; 774. DU0XA2, CXCR1, CSF3, SELE,

[0223] 1185 HCAR3, N0S2; 775. DU0XA2, CXCR1, CSF3, SELE, 0DC1, IL6; 776. DU0XA2, CXCR1, CSF3, SELE, 0DC1, ITPRLP; 777. DU0XA2, CXCR1, CSF3, SELE, 0DC1, N0S2; 778. DU0XA2, CXCR1, CSF3, SELE, IL6, ITPRLP; 779. DU0XA2, CXCR1, CSF3, SELE, IL6, N0S2; 780. DU0XA2, CXCR1, CSF3, SELE, ITPRLP, N0S2; 781. DU0XA2, CXCR1, CSF3, HCAR3, 0DC1, IL6; 782. DU0XA2, CXCR1, CSF3, HCAR3, 0DC1, ITPRLP; 783. DU0XA2, CXCR1, CSF3, HCAR3, 0DC1, N0S2; 784. DU0XA2, CXCR1, CSF3, HCAR3, IL6,

[0224] 1190 ITPRLP; 785. DU0XA2, CXCR1, CSF3, HCAR3, IL6, N0S2; 786. DU0XA2, CXCR1, CSF3, HCAR3, ITPRLP, N0S2; 787. DU0XA2, CXCR1, CSF3, 0DC1, IL6, ITPRLP; 788. DU0XA2, CXCR1, CSF3, 0DC1, IL6, N0S2;

[0225] 31

[0226] 4935-6038-7201 , v. 2 789. DU0XA2, CXCR1, CSF3, 0DC1, ITPRIP, NOS2; 790. DU0XA2, CXCR1, CSF3, IL6, ITPRIP, NOS2; 791. DU0XA2, CXCR1, S100A12, SELE, HCAR3, ODC1; 792. DU0XA2, CXCR1, S100A12, SELE, HCAR3, IL6; 793. DU0XA2, CXCR1, S100A12, SELE, HCAR3, ITPRIP; 794. DU0XA2, CXCR1, S100A12, SELE,

[0227] 1195 HCAR3, N0S2; 795. DU0XA2, CXCR1, S100A12, SELE, 0DC1, IL6; 796. DU0XA2, CXCR1, S100A12, SELE, 0DC1, ITPRIP; 797. DU0XA2, CXCR1, S100A12, SELE, 0DC1, N0S2; 798. DU0XA2, CXCR1, S100A12, SELE, IL6, ITPRIP; 799. DU0XA2, CXCR1, S100A12, SELE, IL6, N0S2; 800. DU0XA2, CXCR1, S100A12, SELE, ITPRIP, N0S2; 801. DU0XA2, CXCR1, S100A12, HCAR3, 0DC1, IL6; 802. DU0XA2, CXCR1, S100A12, HCAR3, 0DC1, ITPRIP; 803. DU0XA2, CXCR1, S100A12, HCAR3, 0DC1, N0S2; 804. DU0XA2,

[0228] 1200 CXCR1, S100A12, HCAR3, IL6, ITPRIP; 805. DU0XA2, CXCR1, S100A12, HCAR3, IL6, N0S2; 806. DU0XA2, CXCR1, S100A12, HCAR3, ITPRIP, N0S2; 807. DU0XA2, CXCR1, S100A12, 0DC1, IL6, ITPRIP; 808. DU0XA2, CXCR1, S100A12, 0DC1, IL6, N0S2; 809. DU0XA2, CXCR1, S100A12, 0DC1, ITPRIP, N0S2; 810. DU0XA2, CXCR1, S100A12, IL6, ITPRIP, N0S2; 811. DU0XA2, CXCR1, SELE, HCAR3, 0DC1, IL6; 812. DU0XA2, CXCR1, SELE, HCAR3, 0DC1, ITPRIP; 813. DU0XA2, CXCR1, SELE, HCAR3, 0DC1,

[0229] 1205 N0S2; 814. DU0XA2, CXCR1, SELE, HCAR3, IL6, ITPRIP; 815. DU0XA2, CXCR1, SELE, HCAR3, IL6, N0S2; 816. DU0XA2, CXCR1, SELE, HCAR3, ITPRIP, N0S2; 817. DU0XA2, CXCR1, SELE, 0DC1, IL6, ITPRIP; 818. DU0XA2, CXCR1, SELE, 0DC1, IL6, N0S2; 819. DU0XA2, CXCR1, SELE, 0DC1, ITPRIP, N0S2; 820. DU0XA2, CXCR1, SELE, IL6, ITPRIP, N0S2; 821. DU0XA2, CXCR1, HCAR3, 0DC1, IL6, ITPRIP; 822. DU0XA2, CXCR1, HCAR3, 0DC1, IL6, N0S2; 823. DU0XA2, CXCR1, HCAR3, 0DC1,

[0230] 1210 ITPRIP, N0S2; 824. DU0XA2, CXCR1, HCAR3, IL6, ITPRIP, N0S2; 825. DU0XA2, CXCR1, 0DC1, IL6, ITPRIP, N0S2; 826. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12; 827. DU0XA2, CCL4, MMP1, MMP2, CSF3, SELE; 828. DU0XA2, CCL4, MMP1, MMP2, CSF3, HCAR3; 829. DU0XA2, CCL4, MMP1, MMP2, CSF3, 0DC1; 830. DU0XA2, CCL4, MMP1, MMP2, CSF3, IL6; 831. DU0XA2, CCL4, MMP1, MMP2, CSF3, ITPRIP; 832. DU0XA2, CCL4, MMP1, MMP2, CSF3, N0S2; 833. DU0XA2, CCL4, MMP1, MMP2, S100A12,

[0231] 1215 SELE; 834. DU0XA2, CCL4, MMP1, MMP2, S100A12, HCAR3; 835. DU0XA2, CCL4, MMP1, MMP2, S100A12, 0DC1; 836. DU0XA2, CCL4, MMP1, MMP2, S100A12, IL6; 837. DU0XA2, CCL4, MMP1, MMP2, S100A12, ITPRIP; 838. DU0XA2, CCL4, MMP1, MMP2, S100A12, N0S2; 839. DU0XA2, CCL4, MMP1, MMP2, SELE, HCAR3; 840. DU0XA2, CCL4, MMP1, MMP2, SELE, 0DC1; 841. DU0XA2, CCL4, MMP1, MMP2, SELE, IL6; 842. DU0XA2, CCL4, MMP1, MMP2, SELE, ITPRIP; 843. DU0XA2, CCL4, MMP1,

[0232] 1220 MMP2, SELE, N0S2; 844. DU0XA2, CCL4, MMP1, MMP2, HCAR3, 0DC1; 845. DU0XA2, CCL4, MMP1, MMP2, HCAR3, IL6; 846. DU0XA2, CCL4, MMP1, MMP2, HCAR3, ITPRIP; 847. DU0XA2, CCL4, MMP1, MMP2, HCAR3, N0S2; 848. DU0XA2, CCL4, MMP1, MMP2, 0DC1, IL6; 849. DU0XA2, CCL4, MMP1, MMP2, 0DC1, ITPRIP; 850. DU0XA2, CCL4, MMP1, MMP2, 0DC1, N0S2; 851. DU0XA2, CCL4, MMP1, MMP2, IL6, ITPRIP; 852. DU0XA2, CCL4, MMP1, MMP2, IL6, N0S2; 853. DU0XA2, CCL4, MMP1, MMP2,

[0233] 1225 ITPRIP, N0S2; 854. DU0XA2, CCL4, MMP1, CSF3, S100A12, SELE; 855. DU0XA2, CCL4, MMP1, CSF3, S100A12, HCAR3; 856. DU0XA2, CCL4, MMP1, CSF3, S100A12, 0DC1; 857. DU0XA2, CCL4, MMP1, CSF3, S100A12, IL6; 858. DU0XA2, CCL4, MMP1, CSF3, S100A12, ITPRIP; 859. DU0XA2, CCL4, MMP1, CSF3, S100A12, N0S2; 860. DU0XA2, CCL4, MMP1, CSF3, SELE, HCAR3; 861. DU0XA2, CCL4, MMP1, CSF3, SELE, 0DC1; 862. DU0XA2, CCL4, MMP1, CSF3, SELE, IL6; 863. DU0XA2, CCL4, MMP1, CSF3,

[0234] 1230 SELE, ITPRIP; 864. DU0XA2, CCL4, MMP1, CSF3, SELE, N0S2; 865. DU0XA2, CCL4, MMP1, CSF3, HCAR3, 0DC1; 866. DU0XA2, CCL4, MMP1, CSF3, HCAR3, IL6; 867. DU0XA2, CCL4, MMP1, CSF3,

[0235] 32

[0236] 4935-6038-7201 , v. 2 HCAR3, ITPRLP; 868. DU0XA2, CCL4, MMP1, CSF3, HCAR3, NOS2; 869. DU0XA2, CCL4, MMP1, CSF3, 0DC1, IL6; 870. DU0XA2, CCL4, MMP1, CSF3, 0DC1, ITPRIP; 871. DU0XA2, CCL4, MMP1, CSF3, 0DC1, N0S2; 872. DU0XA2, CCL4, MMP1, CSF3, IL6, ITPRIP; 873. DU0XA2, CCL4, MMP1, CSF3, IL6,

[0237] 1235 N0S2; 874. DU0XA2, CCL4, MMP1, CSF3, ITPRIP, N0S2; 875. DU0XA2, CCL4, MMP1, S100A12, SELE, HCAR3; 876. DU0XA2, CCL4, MMP1, S100A12, SELE, 0DC1; 877. DU0XA2, CCL4, MMP1, S100A12, SELE, IL6; 878. DU0XA2, CCL4, MMP1, S100A12, SELE, ITPRLP; 879. DU0XA2, CCL4, MMP1, S100A12, SELE, N0S2; 880. DU0XA2, CCL4, MMP1, S100A12, HCAR3, 0DC1; 881. DU0XA2, CCL4, MMP1, S100A12, HCAR3, IL6; 882. DU0XA2, CCL4, MMP1, S100A12, HCAR3, ITPRLP; 883. DU0XA2, CCL4,

[0238] 1240 MMP1, S100A12, HCAR3, N0S2; 884. DU0XA2, CCL4, MMP1, S100A12, 0DC1, IL6; 885. DU0XA2, CCL4, MMP1, S100A12, 0DC1, ITPRLP; 886. DU0XA2, CCL4, MMP1, S100A12, 0DC1, N0S2; 887. DU0XA2, CCL4, MMP1, S100A12, IL6, ITPRLP; 888. DU0XA2, CCL4, MMP1, S100A12, IL6, N0S2; 889. DU0XA2, CCL4, MMP1, S100A12, ITPRLP, N0S2; 890. DU0XA2, CCL4, MMP1, SELE, HCAR3, 0DC1; 891. DU0XA2, CCL4, MMP1, SELE, HCAR3, IL6; 892. DU0XA2, CCL4, MMP1, SELE, HCAR3, ITPRLP; 893. DU0XA2,

[0239] 1245 CCL4, MMP1, SELE, HCAR3, N0S2; 894. DU0XA2, CCL4, MMP1, SELE, 0DC1, IL6; 895. DU0XA2, CCL4, MMP1, SELE, 0DC1, ITPRLP; 896. DU0XA2, CCL4, MMP1, SELE, 0DC1, N0S2; 897. DU0XA2, CCL4, MMP1, SELE, IL6, ITPRLP; 898. DU0XA2, CCL4, MMP1, SELE, IL6, N0S2; 899. DU0XA2, CCL4, MMP1, SELE, ITPRLP, N0S2; 900. DU0XA2, CCL4, MMP1, HCAR3, 0DC1, IL6; 901. DU0XA2, CCL4, MMP1, HCAR3, 0DC1, ITPRLP; 902. DU0XA2, CCL4, MMP1, HCAR3, 0DC1, N0S2; 903. DU0XA2, CCL4, MMP1,

[0240] 1250 HCAR3, IL6, ITPRLP; 904. DU0XA2, CCL4, MMP1, HCAR3, IL6, N0S2; 905. DU0XA2, CCL4, MMP1, HCAR3, ITPRLP, N0S2; 906. DU0XA2, CCL4, MMP1, 0DC1, IL6, ITPRLP; 907. DU0XA2, CCL4, MMP1, 0DC1, IL6, N0S2; 908. DU0XA2, CCL4, MMP1, 0DC1, ITPRLP, N0S2; 909. DU0XA2, CCL4, MMP1, IL6, ITPRLP, N0S2; 910. DU0XA2, CCL4, MMP2, CSF3, S100A12, SELE; 911. DU0XA2, CCL4, MMP2, CSF3, S100A12, HCAR3; 912. DU0XA2, CCL4, MMP2, CSF3, S100A12, 0DC1; 913. DU0XA2, CCL4, MMP2,

[0241] 1255 CSF3, S100A12, IL6; 914. DU0XA2, CCL4, MMP2, CSF3, S100A12, ITPRLP; 915. DU0XA2, CCL4, MMP2, CSF3, S100A12, N0S2; 916. DU0XA2, CCL4, MMP2, CSF3, SELE, HCAR3; 917. DU0XA2, CCL4, MMP2, CSF3, SELE, 0DC1; 918. DU0XA2, CCL4, MMP2, CSF3, SELE, IL6; 919. DU0XA2, CCL4, MMP2, CSF3, SELE, ITPRLP; 920. DU0XA2, CCL4, MMP2, CSF3, SELE, N0S2; 921. DU0XA2, CCL4, MMP2, CSF3, HCAR3, 0DC1; 922. DU0XA2, CCL4, MMP2, CSF3, HCAR3, IL6; 923. DU0XA2, CCL4, MMP2, CSF3,

[0242] 1260 HCAR3, ITPRLP; 924. DU0XA2, CCL4, MMP2, CSF3, HCAR3, N0S2; 925. DU0XA2, CCL4, MMP2, CSF3, 0DC1, IL6; 926. DU0XA2, CCL4, MMP2, CSF3, 0DC1, ITPRLP; 927. DU0XA2, CCL4, MMP2, CSF3, 0DC1, N0S2; 928. DU0XA2, CCL4, MMP2, CSF3, IL6, ITPRLP; 929. DU0XA2, CCL4, MMP2, CSF3, IL6, N0S2; 930. DU0XA2, CCL4, MMP2, CSF3, ITPRLP, N0S2; 931. DU0XA2, CCL4, MMP2, S100A12, SELE, HCAR3; 932. DU0XA2, CCL4, MMP2, S100A12, SELE, 0DC1; 933. DU0XA2, CCL4, MMP2, S100A12,

[0243] 1265 SELE, IL6; 934. DU0XA2, CCL4, MMP2, S100A12, SELE, ITPRLP; 935. DU0XA2, CCL4, MMP2, S100A12, SELE, N0S2; 936. DU0XA2, CCL4, MMP2, S100A12, HCAR3, 0DC1; 937. DU0XA2, CCL4, MMP2, S100A12, HCAR3, IL6; 938. DU0XA2, CCL4, MMP2, S100A12, HCAR3, ITPRLP; 939. DU0XA2, CCL4, MMP2, S100A12, HCAR3, N0S2; 940. DU0XA2, CCL4, MMP2, S100A12, 0DC1, IL6; 941. DU0XA2, CCL4, MMP2, S100A12, 0DC1, ITPRLP; 942. DU0XA2, CCL4, MMP2, S100A12, 0DC1, N0S2; 943. DU0XA2,

[0244] 1270 CCL4, MMP2, S100A12, IL6, ITPRLP; 944. DU0XA2, CCL4, MMP2, S100A12, IL6, N0S2; 945. DU0XA2, CCL4, MMP2, S100A12, ITPRLP, N0S2; 946. DU0XA2, CCL4, MMP2, SELE, HCAR3, 0DC1; 947. DU0XA2,

[0245] 33

[0246] 4935-6038-7201 , v. 2 CCL4, MMP2, SELE, HCAR3, IL6; 948. DU0XA2, CCL4, MMP2, SELE, HCAR3, ITPRIP; 949. DU0XA2, CCL4, MMP2, SELE, HCAR3, N0S2; 950. DU0XA2, CCL4, MMP2, SELE, 0DC1, IL6; 951. DU0XA2, CCL4, MMP2, SELE, 0DC1, ITPRLP; 952. DU0XA2, CCL4, MMP2, SELE, 0DC1, N0S2; 953. DU0XA2, CCL4,

[0247] 1275 MMP2, SELE, IL6, ITPRLP; 954. DU0XA2, CCL4, MMP2, SELE, IL6, N0S2; 955. DU0XA2, CCL4, MMP2, SELE, ITPRLP, N0S2; 956. DU0XA2, CCL4, MMP2, HCAR3, 0DC1, IL6; 957. DU0XA2, CCL4, MMP2, HCAR3, 0DC1, ITPRLP; 958. DU0XA2, CCL4, MMP2, HCAR3, 0DC1, N0S2; 959. DU0XA2, CCL4, MMP2, HCAR3, IL6, ITPRLP; 960. DU0XA2, CCL4, MMP2, HCAR3, IL6, N0S2; 961. DU0XA2, CCL4, MMP2, HCAR3, ITPRLP, N0S2; 962. DU0XA2, CCL4, MMP2, 0DC1, IL6, ITPRLP; 963. DU0XA2, CCL4, MMP2,

[0248] 1280 0DC1, IL6, N0S2; 964. DU0XA2, CCL4, MMP2, 0DC1, ITPRLP, N0S2; 965. DU0XA2, CCL4, MMP2, IL6, ITPRLP, N0S2; 966. DU0XA2, CCL4, CSF3, S100A12, SELE, HCAR3; 967. DU0XA2, CCL4, CSF3, S100A12, SELE, 0DC1; 968. DU0XA2, CCL4, CSF3, S100A12, SELE, IL6; 969. DU0XA2, CCL4, CSF3, S100A12, SELE, ITPRLP; 970. DU0XA2, CCL4, CSF3, S100A12, SELE, N0S2; 971. DU0XA2, CCL4, CSF3, S100A12, HCAR3, 0DC1; 972. DU0XA2, CCL4, CSF3, S100A12, HCAR3, IL6; 973. DU0XA2, CCL4, CSF3, S100A12,

[0249] 1285 HCAR3, ITPRLP; 974. DU0XA2, CCL4, CSF3, S100A12, HCAR3, N0S2; 975. DU0XA2, CCL4, CSF3, S100A12, 0DC1, IL6; 976. DU0XA2, CCL4, CSF3, S100A12, 0DC1, ITPRLP; 977. DU0XA2, CCL4, CSF3, S100A12, 0DC1, N0S2; 978. DU0XA2, CCL4, CSF3, S100A12, IL6, ITPRLP; 979. DU0XA2, CCL4, CSF3, S100A12, IL6, N0S2; 980. DU0XA2, CCL4, CSF3, S100A12, ITPRLP, N0S2; 981. DU0XA2, CCL4, CSF3, SELE, HCAR3, 0DC1; 982. DU0XA2, CCL4, CSF3, SELE, HCAR3, IL6; 983. DU0XA2, CCL4, CSF3, SELE,

[0250] 1290 HCAR3, ITPRLP; 984. DU0XA2, CCL4, CSF3, SELE, HCAR3, N0S2; 985. DU0XA2, CCL4, CSF3, SELE, 0DC1, IL6; 986. DU0XA2, CCL4, CSF3, SELE, 0DC1, ITPRLP; 987. DU0XA2, CCL4, CSF3, SELE, 0DC1, N0S2; 988. DU0XA2, CCL4, CSF3, SELE, IL6, ITPRLP; 989. DU0XA2, CCL4, CSF3, SELE, IL6, N0S2; 990. DU0XA2, CCL4, CSF3, SELE, ITPRLP, N0S2; 991. DU0XA2, CCL4, CSF3, HCAR3, 0DC1, IL6; 992. DU0XA2, CCL4, CSF3, HCAR3, 0DC1, ITPRLP; 993. DU0XA2, CCL4, CSF3, HCAR3, 0DC1, N0S2; 994.

[0251] 1295 DU0XA2, CCL4, CSF3, HCAR3, IL6, ITPRLP; 995. DU0XA2, CCL4, CSF3, HCAR3, IL6, N0S2; 996. DU0XA2, CCL4, CSF3, HCAR3, ITPRLP, N0S2; 997. DU0XA2, CCL4, CSF3, 0DC1, IL6, ITPRLP; 998. DU0XA2, CCL4, CSF3, 0DC1, IL6, N0S2; 999. DU0XA2, CCL4, CSF3, 0DC1, ITPRLP, N0S2; 1000. DU0XA2, CCL4, CSF3, IL6, ITPRLP, N0S2; 1001. DU0XA2, CCL4, S100A12, SELE, HCAR3, 0DC1; 1002. DU0XA2, CCL4, S100A12, SELE, HCAR3, IL6; 1003. DU0XA2, CCL4, S100A12, SELE, HCAR3, ITPRLP;

[0252] 1300 1004. DU0XA2, CCL4, S100A12, SELE, HCAR3, N0S2; 1005. DU0XA2, CCL4, S100A12, SELE, 0DC1, IL6; 1006. DU0XA2, CCL4, S100A12, SELE, 0DC1, ITPRLP; 1007. DU0XA2, CCL4, S100A12, SELE, 0DC1, N0S2; 1008. DU0XA2, CCL4, S100A12, SELE, IL6, ITPRLP; 1009. DU0XA2, CCL4, S100A12, SELE, IL6, N0S2; 1010. DU0XA2, CCL4, S100A12, SELE, ITPRLP, N0S2; 1011. DU0XA2, CCL4, S100A12, HCAR3, 0DC1, IL6; 1012. DU0XA2, CCL4, S100A12, HCAR3, 0DC1, ITPRLP; 1013. DU0XA2, CCL4, S100A12,

[0253] 1305 HCAR3, 0DC1, N0S2; 1014. DU0XA2, CCL4, S100A12, HCAR3, IL6, ITPRLP; 1015. DU0XA2, CCL4, S100A12, HCAR3, IL6, N0S2; 1016. DU0XA2, CCL4, S100A12, HCAR3, ITPRLP, N0S2; 1017. DU0XA2, CCL4, S100A12, 0DC1, IL6, ITPRLP; 1018. DU0XA2, CCL4, S100A12, 0DC1, IL6, N0S2; 1019. DU0XA2, CCL4, S100A12, 0DC1, ITPRLP, N0S2; 1020. DU0XA2, CCL4, S100A12, IL6, ITPRLP, N0S2; 1021. DU0XA2, CCL4, SELE, HCAR3, 0DC1, IL6; 1022. DU0XA2, CCL4, SELE, HCAR3, 0DC1, ITPRLP; 1023.

[0254] 1310 DU0XA2, CCL4, SELE, HCAR3, 0DC1, N0S2; 1024. DU0XA2, CCL4, SELE, HCAR3, IL6, ITPRLP; 1025. DU0XA2, CCL4, SELE, HCAR3, IL6, N0S2; 1026. DU0XA2, CCL4, SELE, HCAR3, ITPRLP, N0S2; 1027.

[0255] 34

[0256] 4935-6038-7201 , v. 2 DU0XA2, CCL4, SELE, 0DC1, IL6, ITPRIP; 1028. DU0XA2, CCL4, SELE, 0DC1, IL6, NOS2; 1029. DU0XA2, CCL4, SELE, 0DC1, ITPRIP, N0S2; 1030. DU0XA2, CCL4, SELE, IL6, ITPRIP, N0S2; 1031. DU0XA2, CCL4, HCAR3, 0DC1, IL6, ITPRIP; 1032. DU0XA2, CCL4, HCAR3, 0DC1, IL6, N0S2; 1033.

[0257] 1315 DU0XA2, CCL4, HCAR3, 0DC1, ITPRIP, N0S2; 1034. DU0XA2, CCL4, HCAR3, IL6, ITPRIP, N0S2; 1035. DU0XA2, CCL4, 0DC1, IL6, ITPRIP, N0S2; 1036. DU0XA2, MMP1, MMP2, CSF3, S100A12, SELE; 1037. DU0XA2, MMP1, MMP2, CSF3, S100A12, HCAR3; 1038. DU0XA2, MMP1, MMP2, CSF3, S100A12, 0DC1; 1039. DU0XA2, MMP1, MMP2, CSF3, S100A12, IL6; 1040. DU0XA2, MMP1, MMP2, CSF3, S100A12, ITPRIP; 1041. DU0XA2, MMP1, MMP2, CSF3, S100A12, N0S2; 1042. DU0XA2, MMP1, MMP2, CSF3,

[0258] 1320 SELE, HCAR3; 1043. DU0XA2, MMP1, MMP2, CSF3, SELE, 0DC1; 1044. DU0XA2, MMP1, MMP2, CSF3, SELE, IL6; 1045. DU0XA2, MMP1, MMP2, CSF3, SELE, ITPRIP; 1046. DU0XA2, MMP1, MMP2, CSF3, SELE, N0S2; 1047. DU0XA2, MMP1, MMP2, CSF3, HCAR3, 0DC1; 1048. DU0XA2, MMP1, MMP2, CSF3, HCAR3, IL6; 1049. DU0XA2, MMP1, MMP2, CSF3, HCAR3, ITPRIP; 1050. DU0XA2, MMP1, MMP2, CSF3, HCAR3, N0S2; 1051. DU0XA2, MMP1, MMP2, CSF3, 0DC1, IL6; 1052. DU0XA2, MMP1, MMP2, CSF3,

[0259] 1325 0DC1, ITPRIP; 1053. DU0XA2, MMP1, MMP2, CSF3, 0DC1, N0S2; 1054. DU0XA2, MMP1, MMP2, CSF3, IL6, ITPRIP; 1055. DU0XA2, MMP1, MMP2, CSF3, IL6, N0S2; 1056. DU0XA2, MMP1, MMP2, CSF3, ITPRIP, N0S2; 1057. DU0XA2, MMP1, MMP2, S100A12, SELE, HCAR3; 1058. DU0XA2, MMP1, MMP2, S100A12, SELE, 0DC1; 1059. DU0XA2, MMP1, MMP2, S100A12, SELE, IL6; 1060. DU0XA2, MMP1, MMP2, S100A12, SELE, ITPRIP; 1061. DU0XA2, MMP1, MMP2, S100A12, SELE, N0S2; 1062. DU0XA2,

[0260] 1330 MMP1, MMP2, S100A12, HCAR3, 0DC1; 1063. DU0XA2, MMP1, MMP2, S100A12, HCAR3, IL6; 1064. DU0XA2, MMP1, MMP2, S100A12, HCAR3, ITPRIP; 1065. DU0XA2, MMP1, MMP2, S100A12, HCAR3, N0S2; 1066. DU0XA2, MMP1, MMP2, S100A12, 0DC1, IL6; 1067. DU0XA2, MMP1, MMP2, S100A12, 0DC1, ITPRIP; 1068. DU0XA2, MMP1, MMP2, S100A12, 0DC1, N0S2; 1069. DU0XA2, MMP1, MMP2, S100A12, IL6, ITPRIP; 1070. DU0XA2, MMP1, MMP2, S100A12, IL6, N0S2; 1071. DU0XA2, MMP1,

[0261] 1335 MMP2, S100A12, ITPRIP, N0S2; 1072. DU0XA2, MMP1, MMP2, SELE, HCAR3, 0DC1; 1073. DU0XA2, MMP1, MMP2, SELE, HCAR3, IL6; 1074. DU0XA2, MMP1, MMP2, SELE, HCAR3, ITPRIP; 1075. DU0XA2, MMP1, MMP2, SELE, HCAR3, N0S2; 1076. DU0XA2, MMP1, MMP2, SELE, 0DC1, IL6; 1077. DU0XA2, MMP1, MMP2, SELE, 0DC1, ITPRIP; 1078. DU0XA2, MMP1, MMP2, SELE, 0DC1, N0S2; 1079. DU0XA2, MMP1, MMP2, SELE, IL6, ITPRIP; 1080. DU0XA2, MMP1, MMP2, SELE, IL6, N0S2; 1081. DU0XA2,

[0262] 1340 MMP1, MMP2, SELE, ITPRIP, N0S2; 1082. DU0XA2, MMP1, MMP2, HCAR3, 0DC1, IL6; 1083. DU0XA2, MMP1, MMP2, HCAR3, 0DC1, ITPRIP; 1084. DU0XA2, MMP1, MMP2, HCAR3, 0DC1, N0S2; 1085. DU0XA2, MMP1, MMP2, HCAR3, IL6, ITPRIP; 1086. DU0XA2, MMP1, MMP2, HCAR3, IL6, N0S2; 1087. DU0XA2, MMP1, MMP2, HCAR3, ITPRIP, N0S2; 1088. DU0XA2, MMP1, MMP2, 0DC1, IL6, ITPRIP; 1089. DU0XA2, MMP1, MMP2, 0DC1, IL6, N0S2; 1090. DU0XA2, MMP1, MMP2, 0DC1, ITPRIP, N0S2;

[0263] 1345 1091. DU0XA2, MMP1, MMP2, IL6, ITPRIP, N0S2; 1092. DU0XA2, MMP1, CSF3, S100A12, SELE, HCAR3; 1093. DU0XA2, MMP1, CSF3, S100A12, SELE, 0DC1; 1094. DU0XA2, MMP1, CSF3, S100A12, SELE, IL6; 1095. DU0XA2, MMP1, CSF3, S100A12, SELE, ITPRIP; 1096. DU0XA2, MMP1, CSF3, S100A12, SELE, N0S2; 1097. DU0XA2, MMP1, CSF3, S100A12, HCAR3, 0DC1; 1098. DU0XA2, MMP1, CSF3, S100A12, HCAR3, IL6; 1099. DU0XA2, MMP1, CSF3, S100A12, HCAR3, ITPRIP; 1100. DU0XA2, MMP1,

[0264] 1350 CSF3, S100A12, HCAR3, N0S2; 1101. DU0XA2, MMP1, CSF3, S100A12, 0DC1, IL6; 1102. DU0XA2, MMP1, CSF3, S100A12, 0DC1, ITPRIP; 1103. DU0XA2, MMP1, CSF3, S100A12, 0DC1, N0S2; 1104.

[0265] 35

[0266] 4935-6038-7201 , v. 2 DU0XA2, MMP1, CSF3, S100A12, IL6, ITPRLP; 1105. DU0XA2, MMP1, CSF3, S100A12, IL6, NOS2; 1106. DU0XA2, MMP1, CSF3, S100A12, ITPRIP, N0S2; 1107. DU0XA2, MMP1, CSF3, SELE, HCAR3, ODC1; 1108. DU0XA2, MMP1, CSF3, SELE, HCAR3, IL6; 1109. DU0XA2, MMP1, CSF3, SELE, HCAR3, ITPRLP;

[0267] 1355 1110. DU0XA2, MMP1, CSF3, SELE, HCAR3, N0S2; 1111. DU0XA2, MMP1, CSF3, SELE, 0DC1, IL6; 1112. DU0XA2, MMP1, CSF3, SELE, 0DC1, ITPRLP; 1113. DU0XA2, MMP1, CSF3, SELE, 0DC1, N0S2; 1114. DU0XA2, MMP1, CSF3, SELE, IL6, ITPRLP; 1115. DU0XA2, MMP1, CSF3, SELE, IL6, N0S2; 1116. DU0XA2, MMP1, CSF3, SELE, ITPRLP, N0S2; 1117. DU0XA2, MMP1, CSF3, HCAR3, 0DC1, IL6; 1118. DU0XA2, MMP1, CSF3, HCAR3, 0DC1, ITPRLP; 1119. DU0XA2, MMP1, CSF3, HCAR3, 0DC1, N0S2;

[0268] 1360 1120. DU0XA2, MMP1, CSF3, HCAR3, IL6, ITPRLP; 1121. DU0XA2, MMP1, CSF3, HCAR3, IL6, N0S2; 1122. DU0XA2, MMP1, CSF3, HCAR3, ITPRLP, N0S2; 1123. DU0XA2, MMP1, CSF3, 0DC1, IL6, ITPRLP; 1124. DU0XA2, MMP1, CSF3, 0DC1, IL6, N0S2; 1125. DU0XA2, MMP1, CSF3, 0DC1, ITPRLP, N0S2; 1126. DU0XA2, MMP1, CSF3, IL6, ITPRLP, N0S2; 1127. DU0XA2, MMP1, S100A12, SELE, HCAR3, 0DC1; 1128. DU0XA2, MMP1, S100A12, SELE, HCAR3, IL6; 1129. DU0XA2, MMP1, S100A12, SELE, HCAR3,

[0269] 1365 ITPRLP; 1130. DU0XA2, MMP1, S100A12, SELE, HCAR3, N0S2; 1131. DU0XA2, MMP1, S100A12, SELE, 0DC1, IL6; 1132. DU0XA2, MMP1, S100A12, SELE, 0DC1, ITPRLP; 1133. DU0XA2, MMP1, S100A12, SELE, 0DC1, N0S2; 1134. DU0XA2, MMP1, S100A12, SELE, IL6, ITPRLP; 1135. DU0XA2, MMP1, S100A12, SELE, IL6, N0S2; 1136. DU0XA2, MMP1, S100A12, SELE, ITPRLP, N0S2; 1137. DU0XA2, MMP1, S100A12, HCAR3, 0DC1, IL6; 1138. DU0XA2, MMP1, S100A12, HCAR3, 0DC1, ITPRLP; 1139.

[0270] 1370 DU0XA2, MMP1, S100A12, HCAR3, 0DC1, N0S2; 1140. DU0XA2, MMP1, S100A12, HCAR3, IL6, ITPRLP; 1141. DU0XA2, MMP1, S100A12, HCAR3, IL6, N0S2; 1142. DU0XA2, MMP1, S100A12, HCAR3, ITPRLP, N0S2; 1143. DU0XA2, MMP1, S100A12, 0DC1, IL6, ITPRLP; 1144. DU0XA2, MMP1, S100A12, 0DC1, IL6, N0S2; 1145. DU0XA2, MMP1, S100A12, 0DC1, ITPRLP, N0S2; 1146. DU0XA2, MMP1, S100A12, IL6, ITPRLP, N0S2; 1147. DU0XA2, MMP1, SELE, HCAR3, 0DC1, IL6; 1148. DU0XA2, MMP1, SELE, HCAR3,

[0271] 1375 0DC1, ITPRLP; 1149. DU0XA2, MMP1, SELE, HCAR3, 0DC1, N0S2; 1150. DU0XA2, MMP1, SELE, HCAR3, IL6, ITPRLP; 1151. DU0XA2, MMP1, SELE, HCAR3, IL6, N0S2; 1152. DU0XA2, MMP1, SELE, HCAR3, ITPRLP, N0S2; 1153. DU0XA2, MMP1, SELE, 0DC1, IL6, ITPRLP; 1154. DU0XA2, MMP1, SELE, 0DC1, IL6, N0S2; 1155. DU0XA2, MMP1, SELE, 0DC1, ITPRLP, N0S2; 1156. DU0XA2, MMP1, SELE, IL6, ITPRLP, N0S2; 1157. DU0XA2, MMP1, HCAR3, 0DC1, IL6, ITPRLP; 1158. DU0XA2, MMP1, HCAR3,

[0272] 1380 0DC1, IL6, N0S2; 1159. DU0XA2, MMP1, HCAR3, 0DC1, ITPRLP, N0S2; 1160. DU0XA2, MMP1, HCAR3, IL6, ITPRLP, N0S2; 1161. DU0XA2, MMP1, 0DC1, IL6, ITPRLP, N0S2; 1162. DU0XA2, MMP2, CSF3, S100A12, SELE, HCAR3; 1163. DU0XA2, MMP2, CSF3, S100A12, SELE, 0DC1; 1164. DU0XA2, MMP2, CSF3, S100A12, SELE, IL6; 1165. DU0XA2, MMP2, CSF3, S100A12, SELE, ITPRLP; 1166. DU0XA2, MMP2, CSF3, S100A12, SELE, N0S2; 1167. DU0XA2, MMP2, CSF3, S100A12, HCAR3, 0DC1; 1168. DU0XA2,

[0273] 1385 MMP2, CSF3, S100A12, HCAR3, IL6; 1169. DU0XA2, MMP2, CSF3, S100A12, HCAR3, ITPRLP; 1170.

[0274] DU0XA2, MMP2, CSF3, S100A12, HCAR3, N0S2; 1171. DU0XA2, MMP2, CSF3, S100A12, 0DC1, IL6; 1172. DU0XA2, MMP2, CSF3, S100A12, 0DC1, ITPRLP; 1173. DU0XA2, MMP2, CSF3, S100A12, 0DC1, N0S2; 1174. DU0XA2, MMP2, CSF3, S100A12, IL6, ITPRLP; 1175. DU0XA2, MMP2, CSF3, S100A12, IL6, N0S2; 1176. DU0XA2, MMP2, CSF3, S100A12, ITPRLP, N0S2; 1177. DU0XA2, MMP2, CSF3, SELE,

[0275] 1390 HCAR3, 0DC1; 1178. DU0XA2, MMP2, CSF3, SELE, HCAR3, IL6; 1179. DU0XA2, MMP2, CSF3, SELE, HCAR3, ITPRLP; 1180. DU0XA2, MMP2, CSF3, SELE, HCAR3, N0S2; 1181. DU0XA2, MMP2, CSF3, SELE,

[0276] 36

[0277] 4935-6038-7201 , v. 2 0DC1, IL6; 1182. DU0XA2, MMP2, CSF3, SELE, 0DC1, ITPRIP; 1183. DU0XA2, MMP2, CSF3, SELE, 0DC1, N0S2; 1184. DU0XA2, MMP2, CSF3, SELE, IL6, ITPRIP; 1185. DU0XA2, MMP2, CSF3, SELE, IL6, N0S2; 1186. DU0XA2, MMP2, CSF3, SELE, ITPRIP, N0S2; 1187. DU0XA2, MMP2, CSF3, HCAR3, 0DC1,

[0278] 1395 IL6; 1188. DU0XA2, MMP2, CSF3, HCAR3, 0DC1, ITPRIP; 1189. DU0XA2, MMP2, CSF3, HCAR3, 0DC1, N0S2; 1190. DU0XA2, MMP2, CSF3, HCAR3, IL6, ITPRIP; 1191. DU0XA2, MMP2, CSF3, HCAR3, IL6, N0S2; 1192. DU0XA2, MMP2, CSF3, HCAR3, ITPRIP, N0S2; 1193. DU0XA2, MMP2, CSF3, 0DC1, IL6, ITPRIP; 1194. DU0XA2, MMP2, CSF3, 0DC1, IL6, N0S2; 1195. DU0XA2, MMP2, CSF3, 0DC1, ITPRIP, N0S2; 1196. DU0XA2, MMP2, CSF3, IL6, ITPRIP, N0S2; 1197. DU0XA2, MMP2, S100A12, SELE, HCAR3,

[0279] 1400 0DC1; 1198. DU0XA2, MMP2, S100A12, SELE, HCAR3, IL6; 1199. DU0XA2, MMP2, S100A12, SELE, HCAR3, ITPRIP; 1200. DU0XA2, MMP2, S100A12, SELE, HCAR3, N0S2; 1201. DU0XA2, MMP2, S100A12, SELE, 0DC1, IL6; 1202. DU0XA2, MMP2, S100A12, SELE, 0DC1, ITPRIP; 1203. DU0XA2, MMP2, S100A12, SELE, 0DC1, N0S2; 1204. DU0XA2, MMP2, S100A12, SELE, IL6, ITPRIP; 1205. DU0XA2, MMP2, S100A12, SELE, IL6, N0S2; 1206. DU0XA2, MMP2, S100A12, SELE, ITPRIP, N0S2; 1207.

[0280] 1405 DU0XA2, MMP2, S100A12, HCAR3, 0DC1, IL6; 1208. DU0XA2, MMP2, S100A12, HCAR3, 0DC1, ITPRIP; 1209. DU0XA2, MMP2, S100A12, HCAR3, 0DC1, N0S2; 1210. DU0XA2, MMP2, S100A12, HCAR3, IL6, ITPRIP; 1211. DU0XA2, MMP2, S100A12, HCAR3, IL6, N0S2; 1212. DU0XA2, MMP2, S100A12, HCAR3, ITPRIP, N0S2; 1213. DU0XA2, MMP2, S100A12, 0DC1, IL6, ITPRIP; 1214. DU0XA2, MMP2, S100A12, 0DC1, IL6, N0S2; 1215. DU0XA2, MMP2, S100A12, 0DC1, ITPRIP, N0S2; 1216. DU0XA2, MMP2,

[0281] 1410 S100A12, IL6, ITPRIP, N0S2; 1217. DU0XA2, MMP2, SELE, HCAR3, 0DC1, IL6; 1218. DU0XA2, MMP2, SELE, HCAR3, 0DC1, ITPRIP; 1219. DU0XA2, MMP2, SELE, HCAR3, 0DC1, N0S2; 1220. DU0XA2, MMP2, SELE, HCAR3, IL6, ITPRIP; 1221. DU0XA2, MMP2, SELE, HCAR3, IL6, N0S2; 1222. DU0XA2, MMP2, SELE, HCAR3, ITPRIP, N0S2; 1223. DU0XA2, MMP2, SELE, 0DC1, IL6, ITPRIP; 1224. DU0XA2, MMP2, SELE, 0DC1, IL6, N0S2; 1225. DU0XA2, MMP2, SELE, 0DC1, ITPRIP, N0S2; 1226. DU0XA2,

[0282] 1415 MMP2, SELE, IL6, ITPRIP, N0S2; 1227. DU0XA2, MMP2, HCAR3, 0DC1, IL6, ITPRIP; 1228. DU0XA2, MMP2, HCAR3, 0DC1, IL6, N0S2; 1229. DU0XA2, MMP2, HCAR3, 0DC1, ITPRIP, N0S2; 1230. DU0XA2, MMP2, HCAR3, IL6, ITPRIP, N0S2; 1231. DU0XA2, MMP2, 0DC1, IL6, ITPRIP, N0S2; 1232. DU0XA2, CSF3, S100A12, SELE, HCAR3, 0DC1; 1233. DU0XA2, CSF3, S100A12, SELE, HCAR3, IL6; 1234.

[0283] DU0XA2, CSF3, S100A12, SELE, HCAR3, ITPRIP; 1235. DU0XA2, CSF3, S100A12, SELE, HCAR3, N0S2;

[0284] 1420 1236. DU0XA2, CSF3, S100A12, SELE, 0DC1, IL6; 1237. DU0XA2, CSF3, S100A12, SELE, 0DC1, ITPRIP; 1238. DU0XA2, CSF3, S100A12, SELE, 0DC1, N0S2; 1239. DU0XA2, CSF3, S100A12, SELE, IL6, ITPRIP; 1240. DU0XA2, CSF3, S100A12, SELE, IL6, N0S2; 1241. DU0XA2, CSF3, S100A12, SELE, ITPRIP, N0S2; 1242. DU0XA2, CSF3, S100A12, HCAR3, 0DC1, IL6; 1243. DU0XA2, CSF3, S100A12, HCAR3, 0DC1, ITPRIP; 1244. DU0XA2, CSF3, S100A12, HCAR3, 0DC1, N0S2; 1245. DU0XA2, CSF3, S100A12, HCAR3,

[0285] 1425 IL6, ITPRIP; 1246. DU0XA2, CSF3, S100A12, HCAR3, IL6, N0S2; 1247. DU0XA2, CSF3, S100A12, HCAR3, ITPRIP, N0S2; 1248. DU0XA2, CSF3, S100A12, 0DC1, IL6, ITPRIP; 1249. DU0XA2, CSF3, S100A12, 0DC1, IL6, N0S2; 1250. DU0XA2, CSF3, S100A12, 0DC1, ITPRIP, N0S2; 1251. DU0XA2, CSF3, S100A12, IL6, ITPRIP, N0S2; 1252. DU0XA2, CSF3, SELE, HCAR3, 0DC1, IL6; 1253. DU0XA2, CSF3, SELE, HCAR3, 0DC1, ITPRIP; 1254. DU0XA2, CSF3, SELE, HCAR3, 0DC1, N0S2; 1255. DU0XA2, CSF3, SELE,

[0286] 1430 HCAR3, IL6, ITPRIP; 1256. DU0XA2, CSF3, SELE, HCAR3, IL6, N0S2; 1257. DU0XA2, CSF3, SELE, HCAR3, ITPRIP, N0S2; 1258. DU0XA2, CSF3, SELE, 0DC1, IL6, ITPRIP; 1259. DU0XA2, CSF3, SELE,

[0287] 37

[0288] 4935-6038-7201 , v. 2 0DC1, IL6, NOS2; 1260. DU0XA2, CSF3, SELE, 0DC1, ITPRLP, NOS2; 1261. DU0XA2, CSF3, SELE, IL6, ITPRIP, N0S2; 1262. DU0XA2, CSF3, HCAR3, 0DC1, IL6, ITPRIP; 1263. DU0XA2, CSF3, HCAR3, 0DC1, IL6, N0S2; 1264. DU0XA2, CSF3, HCAR3, 0DC1, ITPRIP, N0S2; 1265. DU0XA2, CSF3, HCAR3, IL6,

[0289] 1435 ITPRIP, N0S2; 1266. DU0XA2, CSF3, 0DC1, IL6, ITPRIP, N0S2; 1267. DU0XA2, S100A12, SELE, HCAR3, 0DC1, IL6; 1268. DU0XA2, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 1269. DU0XA2, S100A12, SELE, HCAR3, 0DC1, N0S2; 1270. DU0XA2, S100A12, SELE, HCAR3, IL6, ITPRLP; 1271. DU0XA2, S100A12, SELE, HCAR3, IL6, N0S2; 1272. DU0XA2, S100A12, SELE, HCAR3, ITPRLP, N0S2; 1273. DU0XA2, S100A12, SELE, 0DC1, IL6, ITPRLP; 1274. DU0XA2, S100A12, SELE, 0DC1, IL6, N0S2; 1275. DU0XA2,

[0290] 1440 S100A12, SELE, 0DC1, ITPRLP, N0S2; 1276. DU0XA2, S100A12, SELE, IL6, ITPRLP, N0S2; 1277. DU0XA2, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 1278. DU0XA2, S100A12, HCAR3, 0DC1, IL6, N0S2; 1279. DU0XA2, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 1280. DU0XA2, S100A12, HCAR3, IL6, ITPRLP, N0S2; 1281. DU0XA2, S100A12, 0DC1, IL6, ITPRLP, N0S2; 1282. DU0XA2, SELE, HCAR3, 0DC1, IL6, ITPRLP; 1283. DU0XA2, SELE, HCAR3, 0DC1, IL6, N0S2; 1284. DU0XA2, SELE, HCAR3, 0DC1, ITPRLP,

[0291] 1445 N0S2; 1285. DU0XA2, SELE, HCAR3, IL6, ITPRLP, N0S2; 1286. DU0XA2, SELE, 0DC1, IL6, ITPRLP, N0S2; 1287. DU0XA2, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 1288. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3; 1289. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12; 1290. LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE; 1291. LUCAT1, CXCR1, CCL4, MMP1, MMP2, HCAR3; 1292. LUCAT1, CXCR1, CCL4, MMP1, MMP2, 0DC1; 1293. LUCAT1, CXCR1, CCL4, MMP1, MMP2, IL6; 1294. LUCAT1, CXCR1, CCL4,

[0292] 1450 MMP1, MMP2, ITPRLP; 1295. LUCAT1, CXCR1, CCL4, MMP1, MMP2, N0S2; 1296. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12; 1297. LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE; 1298. LUCAT1, CXCR1, CCL4, MMP1, CSF3, HCAR3; 1299. LUCAT1, CXCR1, CCL4, MMP1, CSF3, 0DC1; 1300. LUCAT1, CXCR1, CCL4, MMP1, CSF3, IL6; 1301. LUCAT1, CXCR1, CCL4, MMP1, CSF3, ITPRLP; 1302. LUCAT1, CXCR1, CCL4, MMP1, CSF3, N0S2; 1303. LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE; 1304. LUCAT1,

[0293] 1455 CXCR1, CCL4, MMP1, S100A12, HCAR3; 1305. LUCAT1, CXCR1, CCL4, MMP1, S100A12, 0DC1; 1306. LUCAT1, CXCR1, CCL4, MMP1, S100A12, IL6; 1307. LUCAT1, CXCR1, CCL4, MMP1, S100A12, ITPRLP; 1308. LUCAT1, CXCR1, CCL4, MMP1, S100A12, N0S2; 1309. LUCAT1, CXCR1, CCL4, MMP1, SELE, HCAR3; 1310. LUCAT1, CXCR1, CCL4, MMP1, SELE, 0DC1; 1311. LUCAT1, CXCR1, CCL4, MMP1, SELE, IL6; 1312. LUCAT1, CXCR1, CCL4, MMP1, SELE, ITPRLP; 1313. LUCAT1, CXCR1, CCL4, MMP1, SELE,

[0294] 1460 N0S2; 1314. LUCAT1, CXCR1, CCL4, MMP1, HCAR3, 0DC1; 1315. LUCAT1, CXCR1, CCL4, MMP1, HCAR3, IL6; 1316. LUCAT1, CXCR1, CCL4, MMP1, HCAR3, ITPRLP; 1317. LUCAT1, CXCR1, CCL4, MMP1, HCAR3, N0S2; 1318. LUCAT1, CXCR1, CCL4, MMP1, 0DC1, IL6; 1319. LUCAT1, CXCR1, CCL4, MMP1, 0DC1, ITPRLP; 1320. LUCAT1, CXCR1, CCL4, MMP1, 0DC1, N0S2; 1321. LUCAT1, CXCR1, CCL4, MMP1, IL6, ITPRLP; 1322. LUCAT1, CXCR1, CCL4, MMP1, IL6, N0S2; 1323. LUCAT1, CXCR1,

[0295] 1465 CCL4, MMP1, ITPRLP, N0S2; 1324. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12; 1325. LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE; 1326. LUCAT1, CXCR1, CCL4, MMP2, CSF3, HCAR3; 1327. LUCAT1, CXCR1, CCL4, MMP2, CSF3, 0DC1; 1328. LUCAT1, CXCR1, CCL4, MMP2, CSF3, IL6; 1329. LUCAT1, CXCR1, CCL4, MMP2, CSF3, ITPRLP; 1330. LUCAT1, CXCR1, CCL4, MMP2, CSF3, N0S2; 1331. LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE; 1332. LUCAT1, CXCR1, CCL4, MMP2, S100A12, HCAR3; 1333.

[0296] 1470 LUCAT1, CXCR1, CCL4, MMP2, S100A12, 0DC1; 1334. LUCAT1, CXCR1, CCL4, MMP2, S100A12, IL6; 1335. LUCAT1, CXCR1, CCL4, MMP2, S100A12, ITPRLP; 1336. LUCAT1, CXCR1, CCL4, MMP2, S100A12,

[0297] 38

[0298] 4935-6038-7201 , v. 2 NOS2; 1337. LUCAT1, CXCR1, CCL4, MMP2, SELE, HCAR3; 1338. LUCAT1, CXCR1, CCL4, MMP2, SELE, ODC1; 1339. LUCAT1, CXCR1, CCL4, MMP2, SELE, IL6; 1340. LUCAT1, CXCR1, CCL4, MMP2, SELE, ITPRLP; 1341. LUCAT1, CXCR1, CCL4, MMP2, SELE, N0S2; 1342. LUCAT1, CXCR1, CCL4, MMP2,

[0299] 1475 HCAR3, 0DC1; 1343. LUCAT1, CXCR1, CCL4, MMP2, HCAR3, IL6; 1344. LUCAT1, CXCR1, CCL4, MMP2, HCAR3, ITPRLP; 1345. LUCAT1, CXCR1, CCL4, MMP2, HCAR3, N0S2; 1346. LUCAT1, CXCR1, CCL4, MMP2, 0DC1, IL6; 1347. LUCAT1, CXCR1, CCL4, MMP2, 0DC1, ITPRLP; 1348. LUCAT1, CXCR1, CCL4, MMP2, 0DC1, N0S2; 1349. LUCAT1, CXCR1, CCL4, MMP2, IL6, ITPRLP; 1350. LUCAT1, CXCR1, CCL4, MMP2, IL6, N0S2; 1351. LUCAT1, CXCR1, CCL4, MMP2, ITPRLP, N0S2; 1352. LUCAT1, CXCR1, CCL4,

[0300] 1480 CSF3, S100A12, SELE; 1353. LUCAT1, CXCR1, CCL4, CSF3, S100A12, HCAR3; 1354. LUCAT1, CXCR1, CCL4, CSF3, S100A12, 0DC1; 1355. LUCAT1, CXCR1, CCL4, CSF3, S100A12, IL6; 1356. LUCAT1, CXCR1, CCL4, CSF3, S100A12, ITPRLP; 1357. LUCAT1, CXCR1, CCL4, CSF3, S100A12, N0S2; 1358. LUCAT1, CXCR1, CCL4, CSF3, SELE, HCAR3; 1359. LUCAT1, CXCR1, CCL4, CSF3, SELE, 0DC1; 1360. LUCAT1, CXCR1, CCL4, CSF3, SELE, IL6; 1361. LUCAT1, CXCR1, CCL4, CSF3, SELE, ITPRLP; 1362. LUCAT1,

[0301] 1485 CXCR1, CCL4, CSF3, SELE, N0S2; 1363. LUCAT1, CXCR1, CCL4, CSF3, HCAR3, 0DC1; 1364. LUCAT1, CXCR1, CCL4, CSF3, HCAR3, IL6; 1365. LUCAT1, CXCR1, CCL4, CSF3, HCAR3, ITPRLP; 1366. LUCAT1, CXCR1, CCL4, CSF3, HCAR3, N0S2; 1367. LUCAT1, CXCR1, CCL4, CSF3, 0DC1, IL6; 1368. LUCAT1, CXCR1, CCL4, CSF3, 0DC1, ITPRLP; 1369. LUCAT1, CXCR1, CCL4, CSF3, 0DC1, N0S2; 1370. LUCAT1, CXCR1, CCL4, CSF3, IL6, ITPRLP; 1371. LUCAT1, CXCR1, CCL4, CSF3, IL6, N0S2; 1372. LUCAT1,

[0302] 1490 CXCR1, CCL4, CSF3, ITPRLP, N0S2; 1373. LUCAT1, CXCR1, CCL4, S100A12, SELE, HCAR3; 1374. LUCAT1, CXCR1, CCL4, S100A12, SELE, 0DC1; 1375. LUCAT1, CXCR1, CCL4, S100A12, SELE, IL6; 1376. LUCAT1, CXCR1, CCL4, S100A12, SELE, ITPRLP; 1377. LUCAT1, CXCR1, CCL4, S100A12, SELE, N0S2; 1378. LUCAT1, CXCR1, CCL4, S100A12, HCAR3, 0DC1; 1379. LUCAT1, CXCR1, CCL4, S100A12, HCAR3, IL6; 1380. LUCAT1, CXCR1, CCL4, S100A12, HCAR3, ITPRLP; 1381. LUCAT1, CXCR1, CCL4, S100A12,

[0303] 1495 HCAR3, N0S2; 1382. LUCAT1, CXCR1, CCL4, S100A12, 0DC1, IL6; 1383. LUCAT1, CXCR1, CCL4, S100A12, 0DC1, ITPRLP; 1384. LUCAT1, CXCR1, CCL4, S100A12, 0DC1, N0S2; 1385. LUCAT1, CXCR1, CCL4, S100A12, IL6, ITPRLP; 1386. LUCAT1, CXCR1, CCL4, S100A12, IL6, N0S2; 1387. LUCAT1, CXCR1, CCL4, S100A12, ITPRLP, N0S2; 1388. LUCAT1, CXCR1, CCL4, SELE, HCAR3, 0DC1; 1389. LUCAT1, CXCR1, CCL4, SELE, HCAR3, IL6; 1390. LUCAT1, CXCR1, CCL4, SELE, HCAR3, ITPRLP; 1391. LUCAT1,

[0304] 1500 CXCR1, CCL4, SELE, HCAR3, N0S2; 1392. LUCAT1, CXCR1, CCL4, SELE, 0DC1, IL6; 1393. LUCAT1, CXCR1, CCL4, SELE, 0DC1, ITPRLP; 1394. LUCAT1, CXCR1, CCL4, SELE, 0DC1, N0S2; 1395. LUCAT1, CXCR1, CCL4, SELE, IL6, ITPRLP; 1396. LUCAT1, CXCR1, CCL4, SELE, IL6, N0S2; 1397. LUCAT1, CXCR1, CCL4, SELE, ITPRLP, N0S2; 1398. LUCAT1, CXCR1, CCL4, HCAR3, 0DC1, IL6; 1399. LUCAT1, CXCR1, CCL4, HCAR3, 0DC1, ITPRLP; 1400. LUCAT1, CXCR1, CCL4, HCAR3, 0DC1, N0S2; 1401.

[0305] 1505 LUCAT1, CXCR1, CCL4, HCAR3, IL6, ITPRLP; 1402. LUCAT1, CXCR1, CCL4, HCAR3, IL6, N0S2; 1403. LUCAT1, CXCR1, CCL4, HCAR3, ITPRLP, N0S2; 1404. LUCAT1, CXCR1, CCL4, 0DC1, IL6, ITPRLP; 1405. LUCAT1, CXCR1, CCL4, 0DC1, IL6, N0S2; 1406. LUCAT1, CXCR1, CCL4, 0DC1, ITPRLP, N0S2; 1407. LUCAT1, CXCR1, CCL4, IL6, ITPRLP, N0S2; 1408. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12; 1409. LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE; 1410. LUCAT1, CXCR1, MMP1, MMP2, CSF3, HCAR3;

[0306] 1510 1411. LUCAT1, CXCR1, MMP1, MMP2, CSF3, 0DC1; 1412. LUCAT1, CXCR1, MMP1, MMP2, CSF3, IL6; 1413. LUCAT1, CXCR1, MMP1, MMP2, CSF3, ITPRLP; 1414. LUCAT1, CXCR1, MMP1, MMP2, CSF3,

[0307] 39

[0308] 4935-6038-7201 , v. 2 NOS2; 1415. LUCAT1, CXCR1, MMP1, MMP2, S100A12, SELE; 1416. LUCAT1, CXCR1, MMP1, MMP2, S100A12, HCAR3; 1417. LUCAT1, CXCR1, MMP1, MMP2, S100A12, ODC1; 1418. LUCAT1, CXCR1, MMP1, MMP2, S100A12, IL6; 1419. LUCAT1, CXCR1, MMP1, MMP2, S100A12, ITPRIP; 1420. LUCAT1, CXCR1,

[0309] 1515 MMP1, MMP2, S100A12, N0S2; 1421. LUCAT1, CXCR1, MMP1, MMP2, SELE, HCAR3; 1422. LUCAT1, CXCR1, MMP1, MMP2, SELE, 0DC1; 1423. LUCAT1, CXCR1, MMP1, MMP2, SELE, IL6; 1424. LUCAT1, CXCR1, MMP1, MMP2, SELE, ITPRLP; 1425. LUCAT1, CXCR1, MMP1, MMP2, SELE, N0S2; 1426. LUCAT1, CXCR1, MMP1, MMP2, HCAR3, 0DC1; 1427. LUCAT1, CXCR1, MMP1, MMP2, HCAR3, IL6; 1428. LUCAT1, CXCR1, MMP1, MMP2, HCAR3, ITPRLP; 1429. LUCAT1, CXCR1, MMP1, MMP2, HCAR3,

[0310] 1520 N0S2; 1430. LUCAT1, CXCR1, MMP1, MMP2, 0DC1, IL6; 1431. LUCAT1, CXCR1, MMP1, MMP2, 0DC1, ITPRLP; 1432. LUCAT1, CXCR1, MMP1, MMP2, 0DC1, N0S2; 1433. LUCAT1, CXCR1, MMP1, MMP2, IL6, ITPRLP; 1434. LUCAT1, CXCR1, MMP1, MMP2, IL6, N0S2; 1435. LUCAT1, CXCR1, MMP1, MMP2, ITPRLP, N0S2; 1436. LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE; 1437. LUCAT1, CXCR1, MMP1, CSF3, S100A12, HCAR3; 1438. LUCAT1, CXCR1, MMP1, CSF3, S100A12, 0DC1; 1439. LUCAT1, CXCR1,

[0311] 1525 MMP1, CSF3, S100A12, IL6; 1440. LUCAT1, CXCR1, MMP1, CSF3, S100A12, ITPRLP; 1441. LUCAT1, CXCR1, MMP1, CSF3, S100A12, N0S2; 1442. LUCAT1, CXCR1, MMP1, CSF3, SELE, HCAR3; 1443. LUCAT1, CXCR1, MMP1, CSF3, SELE, 0DC1; 1444. LUCAT1, CXCR1, MMP1, CSF3, SELE, IL6; 1445. LUCAT1, CXCR1, MMP1, CSF3, SELE, ITPRLP; 1446. LUCAT1, CXCR1, MMP1, CSF3, SELE, N0S2; 1447. LUCAT1, CXCR1, MMP1, CSF3, HCAR3, 0DC1; 1448. LUCAT1, CXCR1, MMP1, CSF3, HCAR3, IL6; 1449.

[0312] 1530 LUCAT1, CXCR1, MMP1, CSF3, HCAR3, ITPRLP; 1450. LUCAT1, CXCR1, MMP1, CSF3, HCAR3, N0S2;

[0313] 1451. LUCAT1, CXCR1, MMP1, CSF3, 0DC1, IL6; 1452. LUCAT1, CXCR1, MMP1, CSF3, 0DC1, ITPRLP; 1453. LUCAT1, CXCR1, MMP1, CSF3, 0DC1, N0S2; 1454. LUCAT1, CXCR1, MMP1, CSF3, IL6, ITPRLP; 1455. LUCAT1, CXCR1, MMP1, CSF3, IL6, N0S2; 1456. LUCAT1, CXCR1, MMP1, CSF3, ITPRLP, N0S2; 1457. LUCAT1, CXCR1, MMP1, S100A12, SELE, HCAR3; 1458. LUCAT1, CXCR1, MMP1, S100A12, SELE,

[0314] 1535 0DC1; 1459. LUCAT1, CXCR1, MMP1, S100A12, SELE, IL6; 1460. LUCAT1, CXCR1, MMP1, S100A12, SELE, ITPRLP; 1461. LUCAT1, CXCR1, MMP1, S100A12, SELE, N0S2; 1462. LUCAT1, CXCR1, MMP1, S100A12, HCAR3, 0DC1; 1463. LUCAT1, CXCR1, MMP1, S100A12, HCAR3, IL6; 1464. LUCAT1, CXCR1, MMP1, S100A12, HCAR3, ITPRLP; 1465. LUCAT1, CXCR1, MMP1, S100A12, HCAR3, N0S2; 1466. LUCAT1, CXCR1, MMP1, S100A12, 0DC1, IL6; 1467. LUCAT1, CXCR1, MMP1, S100A12, 0DC1, ITPRLP;

[0315] 1540 1468. LUCAT1, CXCR1, MMP1, S100A12, 0DC1, N0S2; 1469. LUCAT1, CXCR1, MMP1, S100A12, IL6, ITPRLP; 1470. LUCAT1, CXCR1, MMP1, S100A12, IL6, N0S2; 1471. LUCAT1, CXCR1, MMP1, S100A12, ITPRLP, N0S2; 1472. LUCAT1, CXCR1, MMP1, SELE, HCAR3, 0DC1; 1473. LUCAT1, CXCR1, MMP1, SELE, HCAR3, IL6; 1474. LUCAT1, CXCR1, MMP1, SELE, HCAR3, ITPRLP; 1475. LUCAT1, CXCR1, MMP1, SELE, HCAR3, N0S2; 1476. LUCAT1, CXCR1, MMP1, SELE, 0DC1, IL6; 1477. LUCAT1, CXCR1, MMP1,

[0316] 1545 SELE, 0DC1, ITPRLP; 1478. LUCAT1, CXCR1, MMP1, SELE, 0DC1, N0S2; 1479. LUCAT1, CXCR1, MMP1, SELE, IL6, ITPRLP; 1480. LUCAT1, CXCR1, MMP1, SELE, IL6, N0S2; 1481. LUCAT1, CXCR1, MMP1, SELE, ITPRLP, N0S2; 1482. LUCAT1, CXCR1, MMP1, HCAR3, 0DC1, IL6; 1483. LUCAT1, CXCR1, MMP1, HCAR3, 0DC1, ITPRLP; 1484. LUCAT1, CXCR1, MMP1, HCAR3, 0DC1, N0S2; 1485. LUCAT1, CXCR1, MMP1, HCAR3, IL6, ITPRLP; 1486. LUCAT1, CXCR1, MMP1, HCAR3, IL6, N0S2; 1487. LUCAT1, CXCR1,

[0317] 1550 MMP1, HCAR3, ITPRLP, N0S2; 1488. LUCAT1, CXCR1, MMP1, 0DC1, IL6, ITPRLP; 1489. LUCAT1, CXCR1, MMP1, 0DC1, IL6, N0S2; 1490. LUCAT1, CXCR1, MMP1, 0DC1, ITPRLP, N0S2; 1491. LUCAT1,

[0318] 40

[0319] 4935-6038-7201 , v. 2 CXCR1, MMP1, IL6, ITPRLP, NOS2; 1492. LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE; 1493. LUCAT1, CXCR1, MMP2, CSF3, S100A12, HCAR3; 1494. LUCAT1, CXCR1, MMP2, CSF3, S100A12, ODC1; 1495. LUCAT1, CXCR1, MMP2, CSF3, S100A12, IL6; 1496. LUCAT1, CXCR1, MMP2, CSF3, S100A12, ITPRIP;

[0320] 1555 1497. LUCAT1, CXCR1, MMP2, CSF3, S100A12, N0S2; 1498. LUCAT1, CXCR1, MMP2, CSF3, SELE, HCAR3; 1499. LUCAT1, CXCR1, MMP2, CSF3, SELE, 0DC1; 1500. LUCAT1, CXCR1, MMP2, CSF3, SELE, IL6; 1501. LUCAT1, CXCR1, MMP2, CSF3, SELE, ITPRLP; 1502. LUCAT1, CXCR1, MMP2, CSF3, SELE, N0S2; 1503. LUCAT1, CXCR1, MMP2, CSF3, HCAR3, 0DC1; 1504. LUCAT1, CXCR1, MMP2, CSF3, HCAR3, IL6; 1505. LUCAT1, CXCR1, MMP2, CSF3, HCAR3, ITPRLP; 1506. LUCAT1, CXCR1, MMP2, CSF3,

[0321] 1560 HCAR3, N0S2; 1507. LUCAT1, CXCR1, MMP2, CSF3, 0DC1, IL6; 1508. LUCAT1, CXCR1, MMP2, CSF3, 0DC1, ITPRLP; 1509. LUCAT1, CXCR1, MMP2, CSF3, 0DC1, N0S2; 1510. LUCAT1, CXCR1, MMP2, CSF3, IL6, ITPRLP; 1511. LUCAT1, CXCR1, MMP2, CSF3, IL6, N0S2; 1512. LUCAT1, CXCR1, MMP2, CSF3, ITPRLP, N0S2; 1513. LUCAT1, CXCR1, MMP2, S100A12, SELE, HCAR3; 1514. LUCAT1, CXCR1, MMP2, S100A12, SELE, 0DC1; 1515. LUCAT1, CXCR1, MMP2, S100A12, SELE, IL6; 1516. LUCAT1, CXCR1,

[0322] 1565 MMP2, S100A12, SELE, ITPRLP; 1517. LUCAT1, CXCR1, MMP2, S100A12, SELE, N0S2; 1518. LUCAT1, CXCR1, MMP2, S100A12, HCAR3, 0DC1; 1519. LUCAT1, CXCR1, MMP2, S100A12, HCAR3, IL6; 1520. LUCAT1, CXCR1, MMP2, S100A12, HCAR3, ITPRLP; 1521. LUCAT1, CXCR1, MMP2, S100A12, HCAR3, N0S2; 1522. LUCAT1, CXCR1, MMP2, S100A12, 0DC1, IL6; 1523. LUCAT1, CXCR1, MMP2, S100A12, 0DC1, ITPRLP; 1524. LUCAT1, CXCR1, MMP2, S100A12, 0DC1, N0S2; 1525. LUCAT1, CXCR1, MMP2,

[0323] 1570 S100A12, IL6, ITPRLP; 1526. LUCAT1, CXCR1, MMP2, S100A12, IL6, N0S2; 1527. LUCAT1, CXCR1, MMP2, S100A12, ITPRLP, N0S2; 1528. LUCAT1, CXCR1, MMP2, SELE, HCAR3, 0DC1; 1529. LUCAT1, CXCR1, MMP2, SELE, HCAR3, IL6; 1530. LUCAT1, CXCR1, MMP2, SELE, HCAR3, ITPRLP; 1531. LUCAT1, CXCR1, MMP2, SELE, HCAR3, N0S2; 1532. LUCAT1, CXCR1, MMP2, SELE, 0DC1, IL6; 1533. LUCAT1, CXCR1, MMP2, SELE, 0DC1, ITPRLP; 1534. LUCAT1, CXCR1, MMP2, SELE, 0DC1, N0S2; 1535. LUCAT1,

[0324] 1575 CXCR1, MMP2, SELE, IL6, ITPRLP; 1536. LUCAT1, CXCR1, MMP2, SELE, IL6, N0S2; 1537. LUCAT1, CXCR1, MMP2, SELE, ITPRLP, N0S2; 1538. LUCAT1, CXCR1, MMP2, HCAR3, 0DC1, IL6; 1539. LUCAT1, CXCR1, MMP2, HCAR3, 0DC1, ITPRLP; 1540. LUCAT1, CXCR1, MMP2, HCAR3, 0DC1, N0S2; 1541.

[0325] LUCAT1, CXCR1, MMP2, HCAR3, IL6, ITPRLP; 1542. LUCAT1, CXCR1, MMP2, HCAR3, IL6, N0S2; 1543. LUCAT1, CXCR1, MMP2, HCAR3, ITPRLP, N0S2; 1544. LUCAT1, CXCR1, MMP2, 0DC1, IL6, ITPRLP;

[0326] 1580 1545. LUCAT1, CXCR1, MMP2, 0DC1, IL6, N0S2; 1546. LUCAT1, CXCR1, MMP2, 0DC1, ITPRLP, N0S2; 1547. LUCAT1, CXCR1, MMP2, IL6, ITPRLP, N0S2; 1548. LUCAT1, CXCR1, CSF3, S100A12, SELE, HCAR3; 1549. LUCAT1, CXCR1, CSF3, S100A12, SELE, 0DC1; 1550. LUCAT1, CXCR1, CSF3, S100A12, SELE, IL6; 1551. LUCAT1, CXCR1, CSF3, S100A12, SELE, ITPRLP; 1552. LUCAT1, CXCR1, CSF3, S100A12, SELE, N0S2; 1553. LUCAT1, CXCR1, CSF3, S100A12, HCAR3, 0DC1; 1554. LUCAT1, CXCR1, CSF3,

[0327] 1585 S100A12, HCAR3, IL6; 1555. LUCAT1, CXCR1, CSF3, S100A12, HCAR3, ITPRLP; 1556. LUCAT1, CXCR1, CSF3, S100A12, HCAR3, N0S2; 1557. LUCAT1, CXCR1, CSF3, S100A12, 0DC1, IL6; 1558. LUCAT1, CXCR1, CSF3, S100A12, 0DC1, ITPRLP; 1559. LUCAT1, CXCR1, CSF3, S100A12, 0DC1, N0S2; 1560. LUCAT1, CXCR1, CSF3, S100A12, IL6, ITPRLP; 1561. LUCAT1, CXCR1, CSF3, S100A12, IL6, N0S2; 1562. LUCAT1, CXCR1, CSF3, S100A12, ITPRLP, N0S2; 1563. LUCAT1, CXCR1, CSF3, SELE, HCAR3, 0DC1;

[0328] 1590 1564. LUCAT1, CXCR1, CSF3, SELE, HCAR3, IL6; 1565. LUCAT1, CXCR1, CSF3, SELE, HCAR3, ITPRLP; 1566. LUCAT1, CXCR1, CSF3, SELE, HCAR3, N0S2; 1567. LUCAT1, CXCR1, CSF3, SELE, 0DC1, IL6;

[0329] 41

[0330] 4935-6038-7201 , v. 2 1568. LUCAT1, CXCR1, CSF3, SELE, 0DC1, ITPRIP; 1569. LUCAT1, CXCR1, CSF3, SELE, 0DC1, NOS2; 1570. LUCAT1, CXCR1, CSF3, SELE, IL6, ITPRIP; 1571. LUCAT1, CXCR1, CSF3, SELE, IL6, N0S2; 1572. LUCAT1, CXCR1, CSF3, SELE, ITPRIP, N0S2; 1573. LUCAT1, CXCR1, CSF3, HCAR3, 0DC1, IL6; 1574.

[0331] 1595 LUCAT1, CXCR1, CSF3, HCAR3, 0DC1, ITPRIP; 1575. LUCAT1, CXCR1, CSF3, HCAR3, 0DC1, N0S2; 1576. LUCAT1, CXCR1, CSF3, HCAR3, IL6, ITPRIP; 1577. LUCAT1, CXCR1, CSF3, HCAR3, IL6, N0S2; 1578. LUCAT1, CXCR1, CSF3, HCAR3, ITPRIP, N0S2; 1579. LUCAT1, CXCR1, CSF3, 0DC1, IL6, ITPRIP; 1580. LUCAT1, CXCR1, CSF3, 0DC1, IL6, N0S2; 1581. LUCAT1, CXCR1, CSF3, 0DC1, ITPRIP, N0S2; 1582. LUCAT1, CXCR1, CSF3, IL6, ITPRIP, N0S2; 1583. LUCAT1, CXCR1, S100A12, SELE, HCAR3, 0DC1;

[0332] 1600 1584. LUCAT1, CXCR1, S100A12, SELE, HCAR3, IL6; 1585. LUCAT1, CXCR1, S100A12, SELE, HCAR3, ITPRIP; 1586. LUCAT1, CXCR1, S100A12, SELE, HCAR3, N0S2; 1587. LUCAT1, CXCR1, S100A12, SELE, 0DC1, IL6; 1588. LUCAT1, CXCR1, S100A12, SELE, 0DC1, ITPRIP; 1589. LUCAT1, CXCR1, S100A12, SELE, 0DC1, N0S2; 1590. LUCAT1, CXCR1, S100A12, SELE, IL6, ITPRIP; 1591. LUCAT1, CXCR1, S100A12, SELE, IL6, N0S2; 1592. LUCAT1, CXCR1, S100A12, SELE, ITPRIP, N0S2; 1593. LUCAT1,

[0333] 1605 CXCR1, S100A12, HCAR3, 0DC1, IL6; 1594. LUCAT1, CXCR1, S100A12, HCAR3, 0DC1, ITPRIP; 1595. LUCAT1, CXCR1, S100A12, HCAR3, 0DC1, N0S2; 1596. LUCAT1, CXCR1, S100A12, HCAR3, IL6, ITPRIP; 1597. LUCAT1, CXCR1, S100A12, HCAR3, IL6, N0S2; 1598. LUCAT1, CXCR1, S100A12, HCAR3, ITPRIP, N0S2; 1599. LUCAT1, CXCR1, S100A12, 0DC1, IL6, ITPRIP; 1600. LUCAT1, CXCR1, S100A12, 0DC1, IL6, N0S2; 1601. LUCAT1, CXCR1, S100A12, 0DC1, ITPRIP, N0S2; 1602. LUCAT1, CXCR1, S100A12, IL6,

[0334] 1610 ITPRIP, N0S2; 1603. LUCAT1, CXCR1, SELE, HCAR3, 0DC1, IL6; 1604. LUCAT1, CXCR1, SELE, HCAR3, 0DC1, ITPRIP; 1605. LUCAT1, CXCR1, SELE, HCAR3, 0DC1, N0S2; 1606. LUCAT1, CXCR1, SELE, HCAR3, IL6, ITPRIP; 1607. LUCAT1, CXCR1, SELE, HCAR3, IL6, N0S2; 1608. LUCAT1, CXCR1, SELE, HCAR3, ITPRIP, N0S2; 1609. LUCAT1, CXCR1, SELE, 0DC1, IL6, ITPRIP; 1610. LUCAT1, CXCR1, SELE, 0DC1, IL6, N0S2; 1611. LUCAT1, CXCR1, SELE, 0DC1, ITPRIP, N0S2; 1612. LUCAT1, CXCR1, SELE,

[0335] 1615 IL6, ITPRIP, N0S2; 1613. LUCAT1, CXCR1, HCAR3, 0DC1, IL6, ITPRIP; 1614. LUCAT1, CXCR1, HCAR3, 0DC1, IL6, N0S2; 1615. LUCAT1, CXCR1, HCAR3, 0DC1, ITPRIP, N0S2; 1616. LUCAT1, CXCR1, HCAR3, IL6, ITPRIP, N0S2; 1617. LUCAT1, CXCR1, 0DC1, IL6, ITPRIP, N0S2; 1618. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12; 1619. LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE; 1620. LUCAT1, CCL4, MMP1, MMP2, CSF3, HCAR3; 1621. LUCAT1, CCL4, MMP1, MMP2, CSF3, 0DC1; 1622. LUCAT1, CCL4, MMP1,

[0336] 1620 MMP2, CSF3, IL6; 1623. LUCAT1, CCL4, MMP1, MMP2, CSF3, ITPRIP; 1624. LUCAT1, CCL4, MMP1, MMP2, CSF3, N0S2; 1625. LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE; 1626. LUCAT1, CCL4, MMP1, MMP2, S100A12, HCAR3; 1627. LUCAT1, CCL4, MMP1, MMP2, S100A12, 0DC1; 1628. LUCAT1, CCL4, MMP1, MMP2, S100A12, IL6; 1629. LUCAT1, CCL4, MMP1, MMP2, S100A12, ITPRIP; 1630. LUCAT1, CCL4, MMP1, MMP2, S100A12, N0S2; 1631. LUCAT1, CCL4, MMP1, MMP2, SELE, HCAR3; 1632.

[0337] 1625 LUCAT1, CCL4, MMP1, MMP2, SELE, 0DC1; 1633. LUCAT1, CCL4, MMP1, MMP2, SELE, IL6; 1634. LUCAT1, CCL4, MMP1, MMP2, SELE, ITPRIP; 1635. LUCAT1, CCL4, MMP1, MMP2, SELE, N0S2; 1636. LUCAT1, CCL4, MMP1, MMP2, HCAR3, 0DC1; 1637. LUCAT1, CCL4, MMP1, MMP2, HCAR3, IL6; 1638. LUCAT1, CCL4, MMP1, MMP2, HCAR3, ITPRIP; 1639. LUCAT1, CCL4, MMP1, MMP2, HCAR3, N0S2; 1640. LUCAT1, CCL4, MMP1, MMP2, 0DC1, IL6; 1641. LUCAT1, CCL4, MMP1, MMP2, 0DC1, ITPRIP;

[0338] 1630 1642. LUCAT1, CCL4, MMP1, MMP2, 0DC1, N0S2; 1643. LUCAT1, CCL4, MMP1, MMP2, IL6, ITPRIP; 1644. LUCAT1, CCL4, MMP1, MMP2, IL6, N0S2; 1645. LUCAT1, CCL4, MMP1, MMP2, ITPRIP, N0S2;

[0339] 42

[0340] 4935-6038-7201 , v. 2 1646. LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE; 1647. LUCAT1, CCL4, MMP1, CSF3, S100A12, HCAR3; 1648. LUCAT1, CCL4, MMP1, CSF3, S100A12, ODC1; 1649. LUCAT1, CCL4, MMP1, CSF3, S100A12, IL6; 1650. LUCAT1, CCL4, MMP1, CSF3, S100A12, ITPRIP; 1651. LUCAT1, CCL4, MMP1, CSF3,

[0341] 1635 S100A12, N0S2; 1652. LUCAT1, CCL4, MMP1, CSF3, SELE, HCAR3; 1653. LUCAT1, CCL4, MMP1, CSF3, SELE, 0DC1; 1654. LUCAT1, CCL4, MMP1, CSF3, SELE, IL6; 1655. LUCAT1, CCL4, MMP1, CSF3, SELE, ITPRLP; 1656. LUCAT1, CCL4, MMP1, CSF3, SELE, N0S2; 1657. LUCAT1, CCL4, MMP1, CSF3, HCAR3, 0DC1; 1658. LUCAT1, CCL4, MMP1, CSF3, HCAR3, IL6; 1659. LUCAT1, CCL4, MMP1, CSF3, HCAR3, ITPRLP; 1660. LUCAT1, CCL4, MMP1, CSF3, HCAR3, N0S2; 1661. LUCAT1, CCL4, MMP1, CSF3, 0DC1,

[0342] 1640 IL6; 1662. LUCAT1, CCL4, MMP1, CSF3, 0DC1, ITPRLP; 1663. LUCAT1, CCL4, MMP1, CSF3, 0DC1, N0S2; 1664. LUCAT1, CCL4, MMP1, CSF3, IL6, ITPRLP; 1665. LUCAT1, CCL4, MMP1, CSF3, IL6, N0S2; 1666. LUCAT1, CCL4, MMP1, CSF3, ITPRLP, N0S2; 1667. LUCAT1, CCL4, MMP1, S100A12, SELE, HCAR3; 1668. LUCAT1, CCL4, MMP1, S100A12, SELE, 0DC1; 1669. LUCAT1, CCL4, MMP1, S100A12, SELE, IL6; 1670. LUCAT1, CCL4, MMP1, S100A12, SELE, ITPRLP; 1671. LUCAT1, CCL4, MMP1, S100A12,

[0343] 1645 SELE, N0S2; 1672. LUCAT1, CCL4, MMP1, S100A12, HCAR3, 0DC1; 1673. LUCAT1, CCL4, MMP1, S100A12, HCAR3, IL6; 1674. LUCAT1, CCL4, MMP1, S100A12, HCAR3, ITPRLP; 1675. LUCAT1, CCL4, MMP1, S100A12, HCAR3, N0S2; 1676. LUCAT1, CCL4, MMP1, S100A12, 0DC1, IL6; 1677. LUCAT1, CCL4, MMP1, S100A12, 0DC1, ITPRLP; 1678. LUCAT1, CCL4, MMP1, S100A12, 0DC1, N0S2; 1679. LUCAT1, CCL4, MMP1, S100A12, IL6, ITPRLP; 1680. LUCAT1, CCL4, MMP1, S100A12, IL6, N0S2; 1681.

[0344] 1650 LUCAT1, CCL4, MMP1, S100A12, ITPRLP, N0S2; 1682. LUCAT1, CCL4, MMP1, SELE, HCAR3, 0DC1; 1683. LUCAT1, CCL4, MMP1, SELE, HCAR3, IL6; 1684. LUCAT1, CCL4, MMP1, SELE, HCAR3, ITPRLP; 1685. LUCAT1, CCL4, MMP1, SELE, HCAR3, N0S2; 1686. LUCAT1, CCL4, MMP1, SELE, 0DC1, IL6; 1687. LUCAT1, CCL4, MMP1, SELE, 0DC1, ITPRLP; 1688. LUCAT1, CCL4, MMP1, SELE, 0DC1, N0S2; 1689. LUCAT1, CCL4, MMP1, SELE, IL6, ITPRLP; 1690. LUCAT1, CCL4, MMP1, SELE, IL6, N0S2; 1691.

[0345] 1655 LUCAT1, CCL4, MMP1, SELE, ITPRLP, N0S2; 1692. LUCAT1, CCL4, MMP1, HCAR3, 0DC1, IL6; 1693. LUCAT1, CCL4, MMP1, HCAR3, 0DC1, ITPRLP; 1694. LUCAT1, CCL4, MMP1, HCAR3, 0DC1, N0S2; 1695. LUCAT1, CCL4, MMP1, HCAR3, IL6, ITPRLP; 1696. LUCAT1, CCL4, MMP1, HCAR3, IL6, N0S2; 1697. LUCAT1, CCL4, MMP1, HCAR3, ITPRLP, N0S2; 1698. LUCAT1, CCL4, MMP1, 0DC1, IL6, ITPRLP; 1699. LUCAT1, CCL4, MMP1, 0DC1, IL6, N0S2; 1700. LUCAT1, CCL4, MMP1, 0DC1, ITPRLP, N0S2;

[0346] 1660 1701. LUCAT1, CCL4, MMP1, IL6, ITPRLP, N0S2; 1702. LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE; 1703. LUCAT1, CCL4, MMP2, CSF3, S100A12, HCAR3; 1704. LUCAT1, CCL4, MMP2, CSF3, S100A12, 0DC1; 1705. LUCAT1, CCL4, MMP2, CSF3, S100A12, IL6; 1706. LUCAT1, CCL4, MMP2, CSF3, S100A12, ITPRLP; 1707. LUCAT1, CCL4, MMP2, CSF3, S100A12, N0S2; 1708. LUCAT1, CCL4, MMP2, CSF3, SELE, HCAR3; 1709. LUCAT1, CCL4, MMP2, CSF3, SELE, 0DC1; 1710. LUCAT1, CCL4, MMP2, CSF3, SELE,

[0347] 1665 IL6; 1711. LUCAT1, CCL4, MMP2, CSF3, SELE, ITPRLP; 1712. LUCAT1, CCL4, MMP2, CSF3, SELE, N0S2; 1713. LUCAT1, CCL4, MMP2, CSF3, HCAR3, 0DC1; 1714. LUCAT1, CCL4, MMP2, CSF3, HCAR3, IL6; 1715. LUCAT1, CCL4, MMP2, CSF3, HCAR3, ITPRLP; 1716. LUCAT1, CCL4, MMP2, CSF3, HCAR3, N0S2; 1717. LUCAT1, CCL4, MMP2, CSF3, 0DC1, IL6; 1718. LUCAT1, CCL4, MMP2, CSF3, 0DC1, ITPRLP;

[0348] 1719. LUCAT1, CCL4, MMP2, CSF3, 0DC1, N0S2; 1720. LUCAT1, CCL4, MMP2, CSF3, IL6, ITPRLP; 1721.

[0349] 1670 LUCAT1, CCL4, MMP2, CSF3, IL6, N0S2; 1722. LUCAT1, CCL4, MMP2, CSF3, ITPRLP, N0S2; 1723. LUCAT1, CCL4, MMP2, S100A12, SELE, HCAR3; 1724. LUCAT1, CCL4, MMP2, S100A12, SELE, 0DC1;

[0350] 43

[0351] 4935-6038-7201 , v. 2 1725. LUCAT1, CCL4, MMP2, S100A12, SELE, IL6; 1726. LUCAT1, CCL4, MMP2, S100A12, SELE, ITPRIP; 1727. LUCAT1, CCL4, MMP2, S100A12, SELE, N0S2; 1728. LUCAT1, CCL4, MMP2, S100A12, HCAR3, ODC1; 1729. LUCAT1, CCL4, MMP2, S100A12, HCAR3, IL6; 1730. LUCAT1, CCL4, MMP2, S100A12,

[0352] 1675 HCAR3, ITPRIP; 1731. LUCAT1, CCL4, MMP2, S100A12, HCAR3, N0S2; 1732. LUCAT1, CCL4, MMP2, S100A12, 0DC1, IL6; 1733. LUCAT1, CCL4, MMP2, S100A12, 0DC1, ITPRIP; 1734. LUCAT1, CCL4, MMP2, S100A12, 0DC1, N0S2; 1735. LUCAT1, CCL4, MMP2, S100A12, IL6, ITPRIP; 1736. LUCAT1, CCL4, MMP2, S100A12, IL6, N0S2; 1737. LUCAT1, CCL4, MMP2, S100A12, ITPRIP, N0S2; 1738. LUCAT1, CCL4, MMP2, SELE, HCAR3, 0DC1; 1739. LUCAT1, CCL4, MMP2, SELE, HCAR3, IL6; 1740. LUCAT1,

[0353] 1680 CCL4, MMP2, SELE, HCAR3, ITPRIP; 1741. LUCAT1, CCL4, MMP2, SELE, HCAR3, N0S2; 1742. LUCAT1, CCL4, MMP2, SELE, 0DC1, IL6; 1743. LUCAT1, CCL4, MMP2, SELE, 0DC1, ITPRIP; 1744. LUCAT1, CCL4, MMP2, SELE, 0DC1, N0S2; 1745. LUCAT1, CCL4, MMP2, SELE, IL6, ITPRIP; 1746. LUCAT1, CCL4, MMP2, SELE, IL6, N0S2; 1747. LUCAT1, CCL4, MMP2, SELE, ITPRIP, N0S2; 1748. LUCAT1, CCL4, MMP2, HCAR3, 0DC1, IL6; 1749. LUCAT1, CCL4, MMP2, HCAR3, 0DC1, ITPRIP; 1750. LUCAT1,

[0354] 1685 CCL4, MMP2, HCAR3, 0DC1, N0S2; 1751. LUCAT1, CCL4, MMP2, HCAR3, IL6, ITPRIP; 1752. LUCAT1, CCL4, MMP2, HCAR3, IL6, N0S2; 1753. LUCAT1, CCL4, MMP2, HCAR3, ITPRIP, N0S2; 1754. LUCAT1, CCL4, MMP2, 0DC1, IL6, ITPRIP; 1755. LUCAT1, CCL4, MMP2, 0DC1, IL6, N0S2; 1756. LUCAT1, CCL4, MMP2, 0DC1, ITPRIP, N0S2; 1757. LUCAT1, CCL4, MMP2, IL6, ITPRIP, N0S2; 1758. LUCAT1, CCL4, CSF3, S100A12, SELE, HCAR3; 1759. LUCAT1, CCL4, CSF3, S100A12, SELE, 0DC1; 1760. LUCAT1, CCL4,

[0355] 1690 CSF3, S100A12, SELE, IL6; 1761. LUCAT1, CCL4, CSF3, S100A12, SELE, ITPRIP; 1762. LUCAT1, CCL4, CSF3, S100A12, SELE, N0S2; 1763. LUCAT1, CCL4, CSF3, S100A12, HCAR3, 0DC1; 1764. LUCAT1, CCL4, CSF3, S100A12, HCAR3, IL6; 1765. LUCAT1, CCL4, CSF3, S100A12, HCAR3, ITPRIP; 1766. LUCAT1, CCL4, CSF3, S100A12, HCAR3, N0S2; 1767. LUCAT1, CCL4, CSF3, S100A12, 0DC1, IL6; 1768. LUCAT1, CCL4, CSF3, S100A12, 0DC1, ITPRIP; 1769. LUCAT1, CCL4, CSF3, S100A12, 0DC1, N0S2; 1770.

[0356] 1695 LUCAT1, CCL4, CSF3, S100A12, IL6, ITPRIP; 1771. LUCAT1, CCL4, CSF3, S100A12, IL6, N0S2; 1772. LUCAT1, CCL4, CSF3, S100A12, ITPRIP, N0S2; 1773. LUCAT1, CCL4, CSF3, SELE, HCAR3, 0DC1; 1774. LUCAT1, CCL4, CSF3, SELE, HCAR3, IL6; 1775. LUCAT1, CCL4, CSF3, SELE, HCAR3, ITPRIP; 1776. LUCAT1, CCL4, CSF3, SELE, HCAR3, N0S2; 1777. LUCAT1, CCL4, CSF3, SELE, 0DC1, IL6; 1778. LUCAT1, CCL4, CSF3, SELE, 0DC1, ITPRIP; 1779. LUCAT1, CCL4, CSF3, SELE, 0DC1, N0S2; 1780.

[0357] 1700 LUCAT1, CCL4, CSF3, SELE, IL6, ITPRIP; 1781. LUCAT1, CCL4, CSF3, SELE, IL6, N0S2; 1782. LUCAT1, CCL4, CSF3, SELE, ITPRIP, N0S2; 1783. LUCAT1, CCL4, CSF3, HCAR3, 0DC1, IL6; 1784. LUCAT1, CCL4, CSF3, HCAR3, 0DC1, ITPRIP; 1785. LUCAT1, CCL4, CSF3, HCAR3, 0DC1, N0S2; 1786. LUCAT1, CCL4, CSF3, HCAR3, IL6, ITPRIP; 1787. LUCAT1, CCL4, CSF3, HCAR3, IL6, N0S2; 1788. LUCAT1, CCL4, CSF3, HCAR3, ITPRIP, N0S2; 1789. LUCAT1, CCL4, CSF3, 0DC1, IL6, ITPRIP; 1790. LUCAT1, CCL4,

[0358] 1705 CSF3, 0DC1, IL6, N0S2; 1791. LUCAT1, CCL4, CSF3, 0DC1, ITPRIP, N0S2; 1792. LUCAT1, CCL4, CSF3, IL6, ITPRIP, N0S2; 1793. LUCAT1, CCL4, S100A12, SELE, HCAR3, 0DC1; 1794. LUCAT1, CCL4, S100A12, SELE, HCAR3, IL6; 1795. LUCAT1, CCL4, S100A12, SELE, HCAR3, ITPRIP; 1796. LUCAT1, CCL4, S100A12, SELE, HCAR3, N0S2; 1797. LUCAT1, CCL4, S100A12, SELE, 0DC1, IL6; 1798. LUCAT1, CCL4, S100A12, SELE, 0DC1, ITPRIP; 1799. LUCAT1, CCL4, S100A12, SELE, 0DC1, N0S2; 1800. LUCAT1,

[0359] 1710 CCL4, S100A12, SELE, IL6, ITPRIP; 1801. LUCAT1, CCL4, S100A12, SELE, IL6, N0S2; 1802. LUCAT1, CCL4, S100A12, SELE, ITPRIP, N0S2; 1803. LUCAT1, CCL4, S100A12, HCAR3, 0DC1, IL6; 1804. LUCAT1,

[0360] 44

[0361] 4935-6038-7201 , v. 2 CCL4, S100A12, HCAR3, 0DC1, ITPRLP; 1805. LUCAT1, CCL4, S100A12, HCAR3, 0DC1, NOS2; 1806. LUCAT1, CCL4, S100A12, HCAR3, IL6, ITPRIP; 1807. LUCAT1, CCL4, S100A12, HCAR3, IL6, N0S2; 1808. LUCAT1, CCL4, S100A12, HCAR3, ITPRIP, N0S2; 1809. LUCAT1, CCL4, S100A12, 0DC1, IL6, ITPRIP;

[0362] 1715 1810. LUCAT1, CCL4, S100A12, 0DC1, IL6, N0S2; 1811. LUCAT1, CCL4, S100A12, 0DC1, ITPRIP, N0S2; 1812. LUCAT1, CCL4, S100A12, IL6, ITPRIP, N0S2; 1813. LUCAT1, CCL4, SELE, HCAR3, 0DC1, IL6; 1814. LUCAT1, CCL4, SELE, HCAR3, 0DC1, ITPRIP; 1815. LUCAT1, CCL4, SELE, HCAR3, 0DC1, N0S2; 1816. LUCAT1, CCL4, SELE, HCAR3, IL6, ITPRLP; 1817. LUCAT1, CCL4, SELE, HCAR3, IL6, N0S2; 1818. LUCAT1, CCL4, SELE, HCAR3, ITPRLP, N0S2; 1819. LUCAT1, CCL4, SELE, 0DC1, IL6, ITPRLP; 1820.

[0363] 1720 LUCAT1, CCL4, SELE, 0DC1, IL6, N0S2; 1821. LUCAT1, CCL4, SELE, 0DC1, ITPRLP, N0S2; 1822. LUCAT1, CCL4, SELE, IL6, ITPRLP, N0S2; 1823. LUCAT1, CCL4, HCAR3, 0DC1, IL6, ITPRLP; 1824. LUCAT1, CCL4, HCAR3, 0DC1, IL6, N0S2; 1825. LUCAT1, CCL4, HCAR3, 0DC1, ITPRLP, N0S2; 1826. LUCAT1, CCL4, HCAR3, IL6, ITPRLP, N0S2; 1827. LUCAT1, CCL4, 0DC1, IL6, ITPRLP, N0S2; 1828. LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE; 1829. LUCAT1, MMP1, MMP2, CSF3, S100A12, HCAR3;

[0364] 1725 1830. LUCAT1, MMP1, MMP2, CSF3, S100A12, 0DC1; 1831. LUCAT1, MMP1, MMP2, CSF3, S100A12, IL6; 1832. LUCAT1, MMP1, MMP2, CSF3, S100A12, ITPRLP; 1833. LUCAT1, MMP1, MMP2, CSF3, S100A12, N0S2; 1834. LUCAT1, MMP1, MMP2, CSF3, SELE, HCAR3; 1835. LUCAT1, MMP1, MMP2, CSF3, SELE, 0DC1; 1836. LUCAT1, MMP1, MMP2, CSF3, SELE, IL6; 1837. LUCAT1, MMP1, MMP2, CSF3, SELE, ITPRLP; 1838. LUCAT1, MMP1, MMP2, CSF3, SELE, N0S2; 1839. LUCAT1, MMP1, MMP2, CSF3, HCAR3,

[0365] 1730 0DC1; 1840. LUCAT1, MMP1, MMP2, CSF3, HCAR3, IL6; 1841. LUCAT1, MMP1, MMP2, CSF3, HCAR3, ITPRLP; 1842. LUCAT1, MMP1, MMP2, CSF3, HCAR3, N0S2; 1843. LUCAT1, MMP1, MMP2, CSF3, 0DC1, IL6; 1844. LUCAT1, MMP1, MMP2, CSF3, 0DC1, ITPRLP; 1845. LUCAT1, MMP1, MMP2, CSF3, 0DC1, N0S2; 1846. LUCAT1, MMP1, MMP2, CSF3, IL6, ITPRLP; 1847. LUCAT1, MMP1, MMP2, CSF3, IL6, N0S2; 1848. LUCAT1, MMP1, MMP2, CSF3, ITPRLP, N0S2; 1849. LUCAT1, MMP1, MMP2, S100A12, SELE,

[0366] 1735 HCAR3; 1850. LUCAT1, MMP1, MMP2, S100A12, SELE, 0DC1; 1851. LUCAT1, MMP1, MMP2, S100A12, SELE, IL6; 1852. LUCAT1, MMP1, MMP2, S100A12, SELE, ITPRLP; 1853. LUCAT1, MMP1, MMP2, S100A12, SELE, N0S2; 1854. LUCAT1, MMP1, MMP2, S100A12, HCAR3, 0DC1; 1855. LUCAT1, MMP1, MMP2, S100A12, HCAR3, IL6; 1856. LUCAT1, MMP1, MMP2, S100A12, HCAR3, ITPRLP; 1857. LUCAT1, MMP1, MMP2, S100A12, HCAR3, N0S2; 1858. LUCAT1, MMP1, MMP2, S100A12, 0DC1, IL6; 1859.

[0367] 1740 LUCAT1, MMP1, MMP2, S100A12, 0DC1, ITPRLP; 1860. LUCAT1, MMP1, MMP2, S100A12, 0DC1, N0S2; 1861. LUCAT1, MMP1, MMP2, S100A12, IL6, ITPRLP; 1862. LUCAT1, MMP1, MMP2, S100A12, IL6, N0S2; 1863. LUCAT1, MMP1, MMP2, S100A12, ITPRLP, N0S2; 1864. LUCAT1, MMP1, MMP2, SELE, HCAR3, 0DC1; 1865. LUCAT1, MMP1, MMP2, SELE, HCAR3, IL6; 1866. LUCAT1, MMP1, MMP2, SELE, HCAR3, ITPRLP; 1867. LUCAT1, MMP1, MMP2, SELE, HCAR3, N0S2; 1868. LUCAT1, MMP1, MMP2, SELE, 0DC1,

[0368] 1745 IL6; 1869. LUCAT1, MMP1, MMP2, SELE, 0DC1, ITPRLP; 1870. LUCAT1, MMP1, MMP2, SELE, 0DC1, N0S2; 1871. LUCAT1, MMP1, MMP2, SELE, IL6, ITPRLP; 1872. LUCAT1, MMP1, MMP2, SELE, IL6, N0S2; 1873. LUCAT1, MMP1, MMP2, SELE, ITPRLP, N0S2; 1874. LUCAT1, MMP1, MMP2, HCAR3, 0DC1, IL6; 1875. LUCAT1, MMP1, MMP2, HCAR3, 0DC1, ITPRLP; 1876. LUCAT1, MMP1, MMP2, HCAR3, 0DC1, N0S2; 1877. LUCAT1, MMP1, MMP2, HCAR3, IL6, ITPRLP; 1878. LUCAT1, MMP1, MMP2, HCAR3, IL6,

[0369] 1750 N0S2; 1879. LUCAT1, MMP1, MMP2, HCAR3, ITPRLP, N0S2; 1880. LUCAT1, MMP1, MMP2, 0DC1, IL6, ITPRLP; 1881. LUCAT1, MMP1, MMP2, 0DC1, IL6, N0S2; 1882. LUCAT1, MMP1, MMP2, 0DC1, ITPRLP,

[0370] 45

[0371] 4935-6038-7201 , v. 2 NOS2; 1883. LUCAT1, MMP1, MMP2, IL6, ITPRLP, NOS2; 1884. LUCAT1, MMP1, CSF3, S100A12, SELE, HCAR3; 1885. LUCAT1, MMP1, CSF3, S100A12, SELE, ODC1; 1886. LUCAT1, MMP1, CSF3, S100A12, SELE, IL6; 1887. LUCAT1, MMP1, CSF3, S100A12, SELE, ITPRLP; 1888. LUCAT1, MMP1, CSF3, S100A12,

[0372] 1755 SELE, N0S2; 1889. LUCAT1, MMP1, CSF3, S100A12, HCAR3, 0DC1; 1890. LUCAT1, MMP1, CSF3, S100A12, HCAR3, IL6; 1891. LUCAT1, MMP1, CSF3, S100A12, HCAR3, ITPRLP; 1892. LUCAT1, MMP1, CSF3, S100A12, HCAR3, N0S2; 1893. LUCAT1, MMP1, CSF3, S100A12, 0DC1, IL6; 1894. LUCAT1, MMP1, CSF3, S100A12, 0DC1, ITPRLP; 1895. LUCAT1, MMP1, CSF3, S100A12, 0DC1, N0S2; 1896. LUCAT1, MMP1, CSF3, S100A12, IL6, ITPRLP; 1897. LUCAT1, MMP1, CSF3, S100A12, IL6, N0S2; 1898. LUCAT1,

[0373] 1760 MMP1, CSF3, S100A12, ITPRLP, N0S2; 1899. LUCAT1, MMP1, CSF3, SELE, HCAR3, 0DC1; 1900. LUCAT1, MMP1, CSF3, SELE, HCAR3, IL6; 1901. LUCAT1, MMP1, CSF3, SELE, HCAR3, ITPRLP; 1902. LUCAT1, MMP1, CSF3, SELE, HCAR3, N0S2; 1903. LUCAT1, MMP1, CSF3, SELE, 0DC1, IL6; 1904. LUCAT1, MMP1, CSF3, SELE, 0DC1, ITPRLP; 1905. LUCAT1, MMP1, CSF3, SELE, 0DC1, N0S2; 1906. LUCAT1, MMP1, CSF3, SELE, IL6, ITPRLP; 1907. LUCAT1, MMP1, CSF3, SELE, IL6, N0S2; 1908.

[0374] 1765 LUCAT1, MMP1, CSF3, SELE, ITPRLP, N0S2; 1909. LUCAT1, MMP1, CSF3, HCAR3, 0DC1, IL6; 1910. LUCAT1, MMP1, CSF3, HCAR3, 0DC1, ITPRLP; 1911. LUCAT1, MMP1, CSF3, HCAR3, 0DC1, N0S2; 1912. LUCAT1, MMP1, CSF3, HCAR3, IL6, ITPRLP; 1913. LUCAT1, MMP1, CSF3, HCAR3, IL6, N0S2; 1914. LUCAT1, MMP1, CSF3, HCAR3, ITPRLP, N0S2; 1915. LUCAT1, MMP1, CSF3, 0DC1, IL6, ITPRLP; 1916. LUCAT1, MMP1, CSF3, 0DC1, IL6, N0S2; 1917. LUCAT1, MMP1, CSF3, 0DC1, ITPRLP, N0S2;

[0375] 1770 1918. LUCAT1, MMP1, CSF3, IL6, ITPRLP, N0S2; 1919. LUCAT1, MMP1, S100A12, SELE, HCAR3, 0DC1; 1920. LUCAT1, MMP1, S100A12, SELE, HCAR3, IL6; 1921. LUCAT1, MMP1, S100A12, SELE, HCAR3, ITPRLP; 1922. LUCAT1, MMP1, S100A12, SELE, HCAR3, N0S2; 1923. LUCAT1, MMP1, S100A12, SELE, 0DC1, IL6; 1924. LUCAT1, MMP1, S100A12, SELE, 0DC1, ITPRLP; 1925. LUCAT1, MMP1, S100A12, SELE, 0DC1, N0S2; 1926. LUCAT1, MMP1, S100A12, SELE, IL6, ITPRLP; 1927. LUCAT1, MMP1, S100A12,

[0376] 1775 SELE, IL6, N0S2; 1928. LUCAT1, MMP1, S100A12, SELE, ITPRLP, N0S2; 1929. LUCAT1, MMP1, S100A12, HCAR3, 0DC1, IL6; 1930. LUCAT1, MMP1, S100A12, HCAR3, 0DC1, ITPRLP; 1931. LUCAT1, MMP1, S100A12, HCAR3, 0DC1, N0S2; 1932. LUCAT1, MMP1, S100A12, HCAR3, IL6, ITPRLP; 1933. LUCAT1, MMP1, S100A12, HCAR3, IL6, N0S2; 1934. LUCAT1, MMP1, S100A12, HCAR3, ITPRLP, N0S2; 1935. LUCAT1, MMP1, S100A12, 0DC1, IL6, ITPRLP; 1936. LUCAT1, MMP1, S100A12, 0DC1, IL6, N0S2; 1937.

[0377] 1780 LUCAT1, MMP1, S100A12, 0DC1, ITPRLP, N0S2; 1938. LUCAT1, MMP1, S100A12, IL6, ITPRLP, N0S2; 1939. LUCAT1, MMP1, SELE, HCAR3, 0DC1, IL6; 1940. LUCAT1, MMP1, SELE, HCAR3, 0DC1, ITPRLP; 1941. LUCAT1, MMP1, SELE, HCAR3, 0DC1, N0S2; 1942. LUCAT1, MMP1, SELE, HCAR3, IL6, ITPRLP; 1943. LUCAT1, MMP1, SELE, HCAR3, IL6, N0S2; 1944. LUCAT1, MMP1, SELE, HCAR3, ITPRLP, N0S2; 1945. LUCAT1, MMP1, SELE, 0DC1, IL6, ITPRLP; 1946. LUCAT1, MMP1, SELE, 0DC1, IL6, N0S2; 1947.

[0378] 1785 LUCAT1, MMP1, SELE, 0DC1, ITPRLP, N0S2; 1948. LUCAT1, MMP1, SELE, IL6, ITPRLP, N0S2; 1949. LUCAT1, MMP1, HCAR3, 0DC1, IL6, ITPRLP; 1950. LUCAT1, MMP1, HCAR3, 0DC1, IL6, N0S2; 1951. LUCAT1, MMP1, HCAR3, 0DC1, ITPRLP, N0S2; 1952. LUCAT1, MMP1, HCAR3, IL6, ITPRLP, N0S2; 1953. LUCAT1, MMP1, 0DC1, IL6, ITPRLP, N0S2; 1954. LUCAT1, MMP2, CSF3, S100A12, SELE, HCAR3; 1955. LUCAT1, MMP2, CSF3, S100A12, SELE, 0DC1; 1956. LUCAT1, MMP2, CSF3, S100A12, SELE, IL6; 1957.

[0379] 1790 LUCAT1, MMP2, CSF3, S100A12, SELE, ITPRLP; 1958. LUCAT1, MMP2, CSF3, S100A12, SELE, N0S2; 1959. LUCAT1, MMP2, CSF3, S100A12, HCAR3, 0DC1; 1960. LUCAT1, MMP2, CSF3, S100A12, HCAR3,

[0380] 46

[0381] 4935-6038-7201 , v. 2 IL6; 1961. LUCAT1, MMP2, CSF3, S100A12, HCAR3, ITPRLP; 1962. LUCAT1, MMP2, CSF3, S100A12, HCAR3, N0S2; 1963. LUCAT1, MMP2, CSF3, S100A12, 0DC1, IL6; 1964. LUCAT1, MMP2, CSF3, S100A12, 0DC1, ITPRIP; 1965. LUCAT1, MMP2, CSF3, S100A12, 0DC1, N0S2; 1966. LUCAT1, MMP2, CSF3,

[0382] 1795 S100A12, IL6, ITPRIP; 1967. LUCAT1, MMP2, CSF3, S100A12, IL6, N0S2; 1968. LUCAT1, MMP2, CSF3, S100A12, ITPRIP, N0S2; 1969. LUCAT1, MMP2, CSF3, SELE, HCAR3, 0DC1; 1970. LUCAT1, MMP2, CSF3, SELE, HCAR3, IL6; 1971. LUCAT1, MMP2, CSF3, SELE, HCAR3, ITPRLP; 1972. LUCAT1, MMP2, CSF3, SELE, HCAR3, N0S2; 1973. LUCAT1, MMP2, CSF3, SELE, 0DC1, IL6; 1974. LUCAT1, MMP2, CSF3, SELE, 0DC1, ITPRLP; 1975. LUCAT1, MMP2, CSF3, SELE, 0DC1, N0S2; 1976. LUCAT1, MMP2, CSF3,

[0383] 1800 SELE, IL6, ITPRLP; 1977. LUCAT1, MMP2, CSF3, SELE, IL6, N0S2; 1978. LUCAT1, MMP2, CSF3, SELE, ITPRLP, N0S2; 1979. LUCAT1, MMP2, CSF3, HCAR3, 0DC1, IL6; 1980. LUCAT1, MMP2, CSF3, HCAR3, 0DC1, ITPRLP; 1981. LUCAT1, MMP2, CSF3, HCAR3, 0DC1, N0S2; 1982. LUCAT1, MMP2, CSF3, HCAR3, IL6, ITPRLP; 1983. LUCAT1, MMP2, CSF3, HCAR3, IL6, N0S2; 1984. LUCAT1, MMP2, CSF3, HCAR3, ITPRLP, N0S2; 1985. LUCAT1, MMP2, CSF3, 0DC1, IL6, ITPRLP; 1986. LUCAT1, MMP2, CSF3,

[0384] 1805 0DC1, IL6, N0S2; 1987. LUCAT1, MMP2, CSF3, 0DC1, ITPRLP, N0S2; 1988. LUCAT1, MMP2, CSF3, IL6, ITPRLP, N0S2; 1989. LUCAT1, MMP2, S100A12, SELE, HCAR3, 0DC1; 1990. LUCAT1, MMP2, S100A12, SELE, HCAR3, IL6; 1991. LUCAT1, MMP2, S100A12, SELE, HCAR3, ITPRLP; 1992. LUCAT1, MMP2, S100A12, SELE, HCAR3, N0S2; 1993. LUCAT1, MMP2, S100A12, SELE, 0DC1, IL6; 1994. LUCAT1, MMP2, S100A12, SELE, 0DC1, ITPRLP; 1995. LUCAT1, MMP2, S100A12, SELE, 0DC1, N0S2; 1996. LUCAT1,

[0385] 1810 MMP2, S100A12, SELE, IL6, ITPRLP; 1997. LUCAT1, MMP2, S100A12, SELE, IL6, N0S2; 1998. LUCAT1, MMP2, S100A12, SELE, ITPRLP, N0S2; 1999. LUCAT1, MMP2, S100A12, HCAR3, 0DC1, IL6; 2000. LUCAT1, MMP2, S100A12, HCAR3, 0DC1, ITPRLP; 2001. LUCAT1, MMP2, S100A12, HCAR3, 0DC1, N0S2; 2002. LUCAT1, MMP2, S100A12, HCAR3, IL6, ITPRLP; 2003. LUCAT1, MMP2, S100A12, HCAR3, IL6, N0S2; 2004. LUCAT1, MMP2, S100A12, HCAR3, ITPRLP, N0S2; 2005. LUCAT1, MMP2, S100A12,

[0386] 1815 0DC1, IL6, ITPRLP; 2006. LUCAT1, MMP2, S100A12, 0DC1, IL6, N0S2; 2007. LUCAT1, MMP2, S100A12, 0DC1, ITPRLP, N0S2; 2008. LUCAT1, MMP2, S100A12, IL6, ITPRLP, N0S2; 2009. LUCAT1, MMP2, SELE, HCAR3, 0DC1, IL6; 2010. LUCAT1, MMP2, SELE, HCAR3, 0DC1, ITPRLP; 2011. LUCAT1, MMP2, SELE, HCAR3, 0DC1, N0S2; 2012. LUCAT1, MMP2, SELE, HCAR3, IL6, ITPRLP; 2013. LUCAT1, MMP2, SELE, HCAR3, IL6, N0S2; 2014. LUCAT1, MMP2, SELE, HCAR3, ITPRLP, N0S2; 2015. LUCAT1, MMP2, SELE,

[0387] 1820 0DC1, IL6, ITPRLP; 2016. LUCAT1, MMP2, SELE, 0DC1, IL6, N0S2; 2017. LUCAT1, MMP2, SELE, 0DC1, ITPRLP, N0S2; 2018. LUCAT1, MMP2, SELE, IL6, ITPRLP, N0S2; 2019. LUCAT1, MMP2, HCAR3, 0DC1, IL6, ITPRLP; 2020. LUCAT1, MMP2, HCAR3, 0DC1, IL6, N0S2; 2021. LUCAT1, MMP2, HCAR3, 0DC1, ITPRLP, N0S2; 2022. LUCAT1, MMP2, HCAR3, IL6, ITPRLP, N0S2; 2023. LUCAT1, MMP2, 0DC1, IL6, ITPRLP, N0S2; 2024. LUCAT1, CSF3, S100A12, SELE, HCAR3, 0DC1; 2025. LUCAT1, CSF3, S100A12,

[0388] 1825 SELE, HCAR3, IL6; 2026. LUCAT1, CSF3, S100A12, SELE, HCAR3, ITPRLP; 2027. LUCAT1, CSF3, S100A12, SELE, HCAR3, N0S2; 2028. LUCAT1, CSF3, S100A12, SELE, 0DC1, IL6; 2029. LUCAT1, CSF3, S100A12, SELE, 0DC1, ITPRLP; 2030. LUCAT1, CSF3, S100A12, SELE, 0DC1, N0S2; 2031. LUCAT1, CSF3, S100A12, SELE, IL6, ITPRLP; 2032. LUCAT1, CSF3, S100A12, SELE, IL6, N0S2; 2033. LUCAT1, CSF3, S100A12, SELE, ITPRLP, N0S2; 2034. LUCAT1, CSF3, S100A12, HCAR3, 0DC1, IL6; 2035. LUCAT1,

[0389] 1830 CSF3, S100A12, HCAR3, 0DC1, ITPRLP; 2036. LUCAT1, CSF3, S100A12, HCAR3, 0DC1, N0S2; 2037. LUCAT1, CSF3, S100A12, HCAR3, IL6, ITPRLP; 2038. LUCAT1, CSF3, S100A12, HCAR3, IL6, N0S2; 2039.

[0390] 47

[0391] 4935-6038-7201 , v. 2 LUCAT1, CSF3, S100A12, HCAR3, ITPRLP, NOS2; 2040. LUCAT1, CSF3, S100A12, 0DC1, IL6, ITPRLP; 2041. LUCAT1, CSF3, S100A12, 0DC1, IL6, N0S2; 2042. LUCAT1, CSF3, S100A12, 0DC1, ITPRIP, N0S2; 2043. LUCAT1, CSF3, S100A12, IL6, ITPRIP, N0S2; 2044. LUCAT1, CSF3, SELE, HCAR3, 0DC1, IL6; 2045.

[0392] 1835 LUCAT1, CSF3, SELE, HCAR3, 0DC1, ITPRIP; 2046. LUCAT1, CSF3, SELE, HCAR3, 0DC1, N0S2; 2047. LUCAT1, CSF3, SELE, HCAR3, IL6, ITPRLP; 2048. LUCAT1, CSF3, SELE, HCAR3, IL6, N0S2; 2049. LUCAT1, CSF3, SELE, HCAR3, ITPRLP, N0S2; 2050. LUCAT1, CSF3, SELE, 0DC1, IL6, ITPRLP; 2051. LUCAT1, CSF3, SELE, 0DC1, IL6, N0S2; 2052. LUCAT1, CSF3, SELE, 0DC1, ITPRLP, N0S2; 2053. LUCAT1, CSF3, SELE, IL6, ITPRLP, N0S2; 2054. LUCAT1, CSF3, HCAR3, 0DC1, IL6, ITPRLP; 2055.

[0393] 1840 LUCAT1, CSF3, HCAR3, 0DC1, IL6, N0S2; 2056. LUCAT1, CSF3, HCAR3, 0DC1, ITPRLP, N0S2; 2057. LUCAT1, CSF3, HCAR3, IL6, ITPRLP, N0S2; 2058. LUCAT1, CSF3, 0DC1, IL6, ITPRLP, N0S2; 2059. LUCAT1, S100A12, SELE, HCAR3, 0DC1, IL6; 2060. LUCAT1, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 2061. LUCAT1, S100A12, SELE, HCAR3, 0DC1, N0S2; 2062. LUCAT1, S100A12, SELE, HCAR3, IL6, ITPRLP; 2063. LUCAT1, S100A12, SELE, HCAR3, IL6, N0S2; 2064. LUCAT1, S100A12, SELE, HCAR3,

[0394] 1845 ITPRLP, N0S2; 2065. LUCAT1, S100A12, SELE, 0DC1, IL6, ITPRLP; 2066. LUCAT1, S100A12, SELE, 0DC1, IL6, N0S2; 2067. LUCAT1, S100A12, SELE, 0DC1, ITPRLP, N0S2; 2068. LUCAT1, S100A12, SELE, IL6, ITPRLP, N0S2; 2069. LUCAT1, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 2070. LUCAT1, S100A12, HCAR3, 0DC1, IL6, N0S2; 2071. LUCAT1, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 2072. LUCAT1, S100A12, HCAR3, IL6, ITPRLP, N0S2; 2073. LUCAT1, S100A12, 0DC1, IL6, ITPRLP, N0S2; 2074. LUCAT1, SELE,

[0395] 1850 HCAR3, 0DC1, IL6, ITPRLP; 2075. LUCAT1, SELE, HCAR3, 0DC1, IL6, N0S2; 2076. LUCAT1, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 2077. LUCAT1, SELE, HCAR3, IL6, ITPRLP, N0S2; 2078. LUCAT1, SELE, 0DC1, IL6, ITPRLP, N0S2; 2079. LUCAT1, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 2080. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12; 2081. CXCR1, CCL4, MMP1, MMP2, CSF3, SELE; 2082. CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3; 2083. CXCR1, CCL4, MMP1, MMP2, CSF3, 0DC1; 2084. CXCR1, CCL4,

[0396] 1855 MMP1, MMP2, CSF3, IL6; 2085. CXCR1, CCL4, MMP1, MMP2, CSF3, ITPRLP; 2086. CXCR1, CCL4, MMP1, MMP2, CSF3, N0S2; 2087. CXCR1, CCL4, MMP1, MMP2, S100A12, SELE; 2088. CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3; 2089. CXCR1, CCL4, MMP1, MMP2, S100A12, 0DC1; 2090. CXCR1, CCL4, MMP1, MMP2, S100A12, IL6; 2091. CXCR1, CCL4, MMP1, MMP2, S100A12, ITPRLP; 2092. CXCR1, CCL4, MMP1, MMP2, S100A12, N0S2; 2093. CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3; 2094. CXCR1,

[0397] 1860 CCL4, MMP1, MMP2, SELE, 0DC1; 2095. CXCR1, CCL4, MMP1, MMP2, SELE, IL6; 2096. CXCR1, CCL4, MMP1, MMP2, SELE, ITPRLP; 2097. CXCR1, CCL4, MMP1, MMP2, SELE, N0S2; 2098. CXCR1, CCL4, MMP1, MMP2, HCAR3, 0DC1; 2099. CXCR1, CCL4, MMP1, MMP2, HCAR3, IL6; 2100. CXCR1, CCL4, MMP1, MMP2, HCAR3, ITPRLP; 2101. CXCR1, CCL4, MMP1, MMP2, HCAR3, N0S2; 2102. CXCR1, CCL4, MMP1, MMP2, 0DC1, IL6; 2103. CXCR1, CCL4, MMP1, MMP2, 0DC1, ITPRLP; 2104. CXCR1, CCL4,

[0398] 1865 MMP1, MMP2, 0DC1, N0S2; 2105. CXCR1, CCL4, MMP1, MMP2, IL6, ITPRLP; 2106. CXCR1, CCL4, MMP1, MMP2, IL6, N0S2; 2107. CXCR1, CCL4, MMP1, MMP2, ITPRLP, N0S2; 2108. CXCR1, CCL4, MMP1, CSF3, S100A12, SELE; 2109. CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3; 2110. CXCR1, CCL4, MMP1, CSF3, S100A12, 0DC1; 2111. CXCR1, CCL4, MMP1, CSF3, S100A12, IL6; 2112. CXCR1, CCL4, MMP1, CSF3, S100A12, ITPRLP; 2113. CXCR1, CCL4, MMP1, CSF3, S100A12, N0S2; 2114. CXCR1, CCL4,

[0399] 1870 MMP1, CSF3, SELE, HCAR3; 2115. CXCR1, CCL4, MMP1, CSF3, SELE, 0DC1; 2116. CXCR1, CCL4, MMP1, CSF3, SELE, IL6; 2117. CXCR1, CCL4, MMP1, CSF3, SELE, ITPRLP; 2118. CXCR1, CCL4, MMP1,

[0400] 48

[0401] 4935-6038-7201 , v. 2 CSF3, SELE, N0S2; 2119. CXCR1, CCL4, MMP1, CSF3, HCAR3, ODC1; 2120. CXCR1, CCL4, MMP1, CSF3, HCAR3, IL6; 2121. CXCR1, CCL4, MMP1, CSF3, HCAR3, ITPRIP; 2122. CXCR1, CCL4, MMP1, CSF3, HCAR3, N0S2; 2123. CXCR1, CCL4, MMP1, CSF3, 0DC1, IL6; 2124. CXCR1, CCL4, MMP1, CSF3, 0DC1,

[0402] 1875 ITPRIP; 2125. CXCR1, CCL4, MMP1, CSF3, 0DC1, N0S2; 2126. CXCR1, CCL4, MMP1, CSF3, IL6, ITPRIP; 2127. CXCR1, CCL4, MMP1, CSF3, IL6, N0S2; 2128. CXCR1, CCL4, MMP1, CSF3, ITPRIP, N0S2; 2129. CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3; 2130. CXCR1, CCL4, MMP1, S100A12, SELE, 0DC1; 2131. CXCR1, CCL4, MMP1, S100A12, SELE, IL6; 2132. CXCR1, CCL4, MMP1, S100A12, SELE, ITPRLP; 2133. CXCR1, CCL4, MMP1, S100A12, SELE, N0S2; 2134. CXCR1, CCL4, MMP1, S100A12, HCAR3, 0DC1; 2135.

[0403] 1880 CXCR1, CCL4, MMP1, S100A12, HCAR3, IL6; 2136. CXCR1, CCL4, MMP1, S100A12, HCAR3, ITPRLP; 2137. CXCR1, CCL4, MMP1, S100A12, HCAR3, N0S2; 2138. CXCR1, CCL4, MMP1, S100A12, 0DC1, IL6; 2139. CXCR1, CCL4, MMP1, S100A12, 0DC1, ITPRLP; 2140. CXCR1, CCL4, MMP1, S100A12, 0DC1, N0S2; 2141. CXCR1, CCL4, MMP1, S100A12, IL6, ITPRLP; 2142. CXCR1, CCL4, MMP1, S100A12, IL6, N0S2; 2143. CXCR1, CCL4, MMP1, S100A12, ITPRLP, N0S2; 2144. CXCR1, CCL4, MMP1, SELE, HCAR3,

[0404] 1885 0DC1; 2145. CXCR1, CCL4, MMP1, SELE, HCAR3, IL6; 2146. CXCR1, CCL4, MMP1, SELE, HCAR3, ITPRLP; 2147. CXCR1, CCL4, MMP1, SELE, HCAR3, N0S2; 2148. CXCR1, CCL4, MMP1, SELE, 0DC1, IL6; 2149. CXCR1, CCL4, MMP1, SELE, 0DC1, ITPRLP; 2150. CXCR1, CCL4, MMP1, SELE, 0DC1, N0S2; 2151. CXCR1, CCL4, MMP1, SELE, IL6, ITPRLP; 2152. CXCR1, CCL4, MMP1, SELE, IL6, N0S2; 2153. CXCR1, CCL4, MMP1, SELE, ITPRLP, N0S2; 2154. CXCR1, CCL4, MMP1, HCAR3, 0DC1, IL6; 2155. CXCR1, CCL4,

[0405] 1890 MMP1, HCAR3, 0DC1, ITPRLP; 2156. CXCR1, CCL4, MMP1, HCAR3, 0DC1, N0S2; 2157. CXCR1, CCL4, MMP1, HCAR3, IL6, ITPRLP; 2158. CXCR1, CCL4, MMP1, HCAR3, IL6, N0S2; 2159. CXCR1, CCL4, MMP1, HCAR3, ITPRLP, N0S2; 2160. CXCR1, CCL4, MMP1, 0DC1, IL6, ITPRLP; 2161. CXCR1, CCL4, MMP1, 0DC1, IL6, N0S2; 2162. CXCR1, CCL4, MMP1, 0DC1, ITPRLP, N0S2; 2163. CXCR1, CCL4, MMP1, IL6, ITPRLP, N0S2; 2164. CXCR1, CCL4, MMP2, CSF3, S100A12, SELE; 2165. CXCR1, CCL4, MMP2, CSF3,

[0406] 1895 S100A12, HCAR3; 2166. CXCR1, CCL4, MMP2, CSF3, S100A12, 0DC1; 2167. CXCR1, CCL4, MMP2, CSF3, S100A12, IL6; 2168. CXCR1, CCL4, MMP2, CSF3, S100A12, ITPRLP; 2169. CXCR1, CCL4, MMP2, CSF3, S100A12, N0S2; 2170. CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3; 2171. CXCR1, CCL4, MMP2, CSF3, SELE, 0DC1; 2172. CXCR1, CCL4, MMP2, CSF3, SELE, IL6; 2173. CXCR1, CCL4, MMP2, CSF3, SELE, ITPRLP; 2174. CXCR1, CCL4, MMP2, CSF3, SELE, N0S2; 2175. CXCR1, CCL4, MMP2, CSF3, HCAR3,

[0407] 1900 0DC1; 2176. CXCR1, CCL4, MMP2, CSF3, HCAR3, IL6; 2177. CXCR1, CCL4, MMP2, CSF3, HCAR3, ITPRLP; 2178. CXCR1, CCL4, MMP2, CSF3, HCAR3, N0S2; 2179. CXCR1, CCL4, MMP2, CSF3, 0DC1, IL6; 2180. CXCR1, CCL4, MMP2, CSF3, 0DC1, ITPRLP; 2181. CXCR1, CCL4, MMP2, CSF3, 0DC1, N0S2; 2182. CXCR1, CCL4, MMP2, CSF3, IL6, ITPRLP; 2183. CXCR1, CCL4, MMP2, CSF3, IL6, N0S2; 2184. CXCR1, CCL4, MMP2, CSF3, ITPRLP, N0S2; 2185. CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3; 2186. CXCR1,

[0408] 1905 CCL4, MMP2, S100A12, SELE, 0DC1; 2187. CXCR1, CCL4, MMP2, S100A12, SELE, IL6; 2188. CXCR1, CCL4, MMP2, S100A12, SELE, ITPRLP; 2189. CXCR1, CCL4, MMP2, S100A12, SELE, N0S2; 2190. CXCR1, CCL4, MMP2, S100A12, HCAR3, 0DC1; 2191. CXCR1, CCL4, MMP2, S100A12, HCAR3, IL6; 2192. CXCR1, CCL4, MMP2, S100A12, HCAR3, ITPRLP; 2193. CXCR1, CCL4, MMP2, S100A12, HCAR3, N0S2; 2194. CXCR1, CCL4, MMP2, S100A12, 0DC1, IL6; 2195. CXCR1, CCL4, MMP2, S100A12, 0DC1, ITPRLP; 2196.

[0409] 1910 CXCR1, CCL4, MMP2, S100A12, 0DC1, N0S2; 2197. CXCR1, CCL4, MMP2, S100A12, IL6, ITPRLP; 2198. CXCR1, CCL4, MMP2, S100A12, IL6, N0S2; 2199. CXCR1, CCL4, MMP2, S100A12, ITPRLP, N0S2; 2200.

[0410] 49

[0411] 4935-6038-7201 , v. 2 CXCR1, CCL4, MMP2, SELE, HCAR3, ODC1; 2201. CXCR1, CCL4, MMP2, SELE, HCAR3, IL6; 2202. CXCR1, CCL4, MMP2, SELE, HCAR3, ITPRIP; 2203. CXCR1, CCL4, MMP2, SELE, HCAR3, N0S2; 2204. CXCR1, CCL4, MMP2, SELE, 0DC1, IL6; 2205. CXCR1, CCL4, MMP2, SELE, 0DC1, ITPRLP; 2206.

[0412] 1915 CXCR1, CCL4, MMP2, SELE, 0DC1, N0S2; 2207. CXCR1, CCL4, MMP2, SELE, IL6, ITPRLP; 2208. CXCR1, CCL4, MMP2, SELE, IL6, N0S2; 2209. CXCR1, CCL4, MMP2, SELE, ITPRLP, N0S2; 2210. CXCR1, CCL4, MMP2, HCAR3, 0DC1, IL6; 2211. CXCR1, CCL4, MMP2, HCAR3, 0DC1, ITPRLP; 2212. CXCR1, CCL4, MMP2, HCAR3, 0DC1, N0S2; 2213. CXCR1, CCL4, MMP2, HCAR3, IL6, ITPRLP; 2214. CXCR1, CCL4, MMP2, HCAR3, IL6, N0S2; 2215. CXCR1, CCL4, MMP2, HCAR3, ITPRLP, N0S2; 2216. CXCR1, CCL4,

[0413] 1920 MMP2, 0DC1, IL6, ITPRLP; 2217. CXCR1, CCL4, MMP2, 0DC1, IL6, N0S2; 2218. CXCR1, CCL4, MMP2, 0DC1, ITPRLP, N0S2; 2219. CXCR1, CCL4, MMP2, IL6, ITPRLP, N0S2; 2220. CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3; 2221. CXCR1, CCL4, CSF3, S100A12, SELE, 0DC1; 2222. CXCR1, CCL4, CSF3, S100A12, SELE, IL6; 2223. CXCR1, CCL4, CSF3, S100A12, SELE, ITPRLP; 2224. CXCR1, CCL4, CSF3, S100A12, SELE, N0S2; 2225. CXCR1, CCL4, CSF3, S100A12, HCAR3, 0DC1; 2226. CXCR1, CCL4, CSF3,

[0414] 1925 S100A12, HCAR3, IL6; 2227. CXCR1, CCL4, CSF3, S100A12, HCAR3, ITPRLP; 2228. CXCR1, CCL4, CSF3, S100A12, HCAR3, N0S2; 2229. CXCR1, CCL4, CSF3, S100A12, 0DC1, IL6; 2230. CXCR1, CCL4, CSF3, S100A12, 0DC1, ITPRLP; 2231. CXCR1, CCL4, CSF3, S100A12, 0DC1, N0S2; 2232. CXCR1, CCL4, CSF3, S100A12, IL6, ITPRLP; 2233. CXCR1, CCL4, CSF3, S100A12, IL6, N0S2; 2234. CXCR1, CCL4, CSF3, S100A12, ITPRLP, N0S2; 2235. CXCR1, CCL4, CSF3, SELE, HCAR3, 0DC1; 2236. CXCR1, CCL4, CSF3,

[0415] 1930 SELE, HCAR3, IL6; 2237. CXCR1, CCL4, CSF3, SELE, HCAR3, ITPRLP; 2238. CXCR1, CCL4, CSF3, SELE, HCAR3, N0S2; 2239. CXCR1, CCL4, CSF3, SELE, 0DC1, IL6; 2240. CXCR1, CCL4, CSF3, SELE, 0DC1, ITPRLP; 2241. CXCR1, CCL4, CSF3, SELE, 0DC1, N0S2; 2242. CXCR1, CCL4, CSF3, SELE, IL6, ITPRLP; 2243. CXCR1, CCL4, CSF3, SELE, IL6, N0S2; 2244. CXCR1, CCL4, CSF3, SELE, ITPRLP, N0S2; 2245. CXCR1, CCL4, CSF3, HCAR3, 0DC1, IL6; 2246. CXCR1, CCL4, CSF3, HCAR3, 0DC1, ITPRLP; 2247.

[0416] 1935 CXCR1, CCL4, CSF3, HCAR3, 0DC1, N0S2; 2248. CXCR1, CCL4, CSF3, HCAR3, IL6, ITPRLP; 2249.

[0417] CXCR1, CCL4, CSF3, HCAR3, IL6, N0S2; 2250. CXCR1, CCL4, CSF3, HCAR3, ITPRLP, N0S2; 2251. CXCR1, CCL4, CSF3, 0DC1, IL6, ITPRLP; 2252. CXCR1, CCL4, CSF3, 0DC1, IL6, N0S2; 2253. CXCR1, CCL4, CSF3, 0DC1, ITPRLP, N0S2; 2254. CXCR1, CCL4, CSF3, IL6, ITPRLP, N0S2; 2255. CXCR1, CCL4, S100A12, SELE, HCAR3, 0DC1; 2256. CXCR1, CCL4, S100A12, SELE, HCAR3, IL6; 2257. CXCR1, CCL4,

[0418] 1940 S100A12, SELE, HCAR3, ITPRLP; 2258. CXCR1, CCL4, S100A12, SELE, HCAR3, N0S2; 2259. CXCR1, CCL4, S100A12, SELE, 0DC1, IL6; 2260. CXCR1, CCL4, S100A12, SELE, 0DC1, ITPRLP; 2261. CXCR1, CCL4, S100A12, SELE, 0DC1, N0S2; 2262. CXCR1, CCL4, S100A12, SELE, IL6, ITPRLP; 2263. CXCR1, CCL4, S100A12, SELE, IL6, N0S2; 2264. CXCR1, CCL4, S100A12, SELE, ITPRLP, N0S2; 2265. CXCR1, CCL4, S100A12, HCAR3, 0DC1, IL6; 2266. CXCR1, CCL4, S100A12, HCAR3, 0DC1, ITPRLP; 2267. CXCR1,

[0419] 1945 CCL4, S100A12, HCAR3, 0DC1, N0S2; 2268. CXCR1, CCL4, S100A12, HCAR3, IL6, ITPRLP; 2269. CXCR1, CCL4, S100A12, HCAR3, IL6, N0S2; 2270. CXCR1, CCL4, S100A12, HCAR3, ITPRLP, N0S2; 2271. CXCR1, CCL4, S100A12, 0DC1, IL6, ITPRLP; 2272. CXCR1, CCL4, S100A12, 0DC1, IL6, N0S2; 2273. CXCR1, CCL4, S100A12, 0DC1, ITPRLP, N0S2; 2274. CXCR1, CCL4, S100A12, IL6, ITPRLP, N0S2; 2275. CXCR1, CCL4, SELE, HCAR3, 0DC1, IL6; 2276. CXCR1, CCL4, SELE, HCAR3, 0DC1, ITPRLP; 2277. CXCR1,

[0420] 1950 CCL4, SELE, HCAR3, 0DC1, N0S2; 2278. CXCR1, CCL4, SELE, HCAR3, IL6, ITPRLP; 2279. CXCR1, CCL4, SELE, HCAR3, IL6, N0S2; 2280. CXCR1, CCL4, SELE, HCAR3, ITPRLP, N0S2; 2281. CXCR1, CCL4, SELE,

[0421] 50

[0422] 4935-6038-7201 , v. 2 0DC1, IL6, ITPRIP; 2282. CXCR1, CCL4, SELE, 0DC1, IL6, NOS2; 2283. CXCR1, CCL4, SELE, 0DC1, ITPRIP, N0S2; 2284. CXCR1, CCL4, SELE, IL6, ITPRIP, N0S2; 2285. CXCR1, CCL4, HCAR3, 0DC1, IL6, ITPRIP; 2286. CXCR1, CCL4, HCAR3, 0DC1, IL6, N0S2; 2287. CXCR1, CCL4, HCAR3, 0DC1, ITPRIP,

[0423] 1955 N0S2; 2288. CXCR1, CCL4, HCAR3, IL6, ITPRIP, N0S2; 2289. CXCR1, CCL4, 0DC1, IL6, ITPRIP, N0S2; 2290. CXCR1, MMP1, MMP2, CSF3, S100A12, SELE; 2291. CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3; 2292. CXCR1, MMP1, MMP2, CSF3, S100A12, 0DC1; 2293. CXCR1, MMP1, MMP2, CSF3, S100A12, IL6; 2294. CXCR1, MMP1, MMP2, CSF3, S100A12, ITPRIP; 2295. CXCR1, MMP1, MMP2, CSF3, S100A12, N0S2; 2296. CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3; 2297. CXCR1, MMP1, MMP2, CSF3,

[0424] 1960 SELE, 0DC1; 2298. CXCR1, MMP1, MMP2, CSF3, SELE, IL6; 2299. CXCR1, MMP1, MMP2, CSF3, SELE, ITPRIP; 2300. CXCR1, MMP1, MMP2, CSF3, SELE, N0S2; 2301. CXCR1, MMP1, MMP2, CSF3, HCAR3, 0DC1; 2302. CXCR1, MMP1, MMP2, CSF3, HCAR3, IL6; 2303. CXCR1, MMP1, MMP2, CSF3, HCAR3, ITPRIP; 2304. CXCR1, MMP1, MMP2, CSF3, HCAR3, N0S2; 2305. CXCR1, MMP1, MMP2, CSF3, 0DC1, IL6; 2306. CXCR1, MMP1, MMP2, CSF3, 0DC1, ITPRIP; 2307. CXCR1, MMP1, MMP2, CSF3, 0DC1,

[0425] 1965 N0S2; 2308. CXCR1, MMP1, MMP2, CSF3, IL6, ITPRIP; 2309. CXCR1, MMP1, MMP2, CSF3, IL6, N0S2; 2310. CXCR1, MMP1, MMP2, CSF3, ITPRIP, N0S2; 2311. CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3; 2312. CXCR1, MMP1, MMP2, S100A12, SELE, 0DC1; 2313. CXCR1, MMP1, MMP2, S100A12, SELE, IL6; 2314. CXCR1, MMP1, MMP2, S100A12, SELE, ITPRIP; 2315. CXCR1, MMP1, MMP2, S100A12, SELE, N0S2; 2316. CXCR1, MMP1, MMP2, S100A12, HCAR3, 0DC1; 2317. CXCR1, MMP1, MMP2, S100A12,

[0426] 1970 HCAR3, IL6; 2318. CXCR1, MMP1, MMP2, S100A12, HCAR3, ITPRIP; 2319. CXCR1, MMP1, MMP2, S100A12, HCAR3, N0S2; 2320. CXCR1, MMP1, MMP2, S100A12, 0DC1, IL6; 2321. CXCR1, MMP1, MMP2, S100A12, 0DC1, ITPRIP; 2322. CXCR1, MMP1, MMP2, S100A12, 0DC1, N0S2; 2323. CXCR1, MMP1, MMP2, S100A12, IL6, ITPRIP; 2324. CXCR1, MMP1, MMP2, S100A12, IL6, N0S2; 2325. CXCR1, MMP1, MMP2, S100A12, ITPRIP, N0S2; 2326. CXCR1, MMP1, MMP2, SELE, HCAR3, 0DC1; 2327. CXCR1,

[0427] 1975 MMP1, MMP2, SELE, HCAR3, IL6; 2328. CXCR1, MMP1, MMP2, SELE, HCAR3, ITPRIP; 2329. CXCR1, MMP1, MMP2, SELE, HCAR3, N0S2; 2330. CXCR1, MMP1, MMP2, SELE, 0DC1, IL6; 2331. CXCR1, MMP1, MMP2, SELE, 0DC1, ITPRIP; 2332. CXCR1, MMP1, MMP2, SELE, 0DC1, N0S2; 2333. CXCR1, MMP1, MMP2, SELE, IL6, ITPRIP; 2334. CXCR1, MMP1, MMP2, SELE, IL6, N0S2; 2335. CXCR1, MMP1, MMP2, SELE, ITPRIP, N0S2; 2336. CXCR1, MMP1, MMP2, HCAR3, 0DC1, IL6; 2337. CXCR1, MMP1,

[0428] 1980 MMP2, HCAR3, 0DC1, ITPRIP; 2338. CXCR1, MMP1, MMP2, HCAR3, 0DC1, N0S2; 2339. CXCR1, MMP1, MMP2, HCAR3, IL6, ITPRIP; 2340. CXCR1, MMP1, MMP2, HCAR3, IL6, N0S2; 2341. CXCR1, MMP1, MMP2, HCAR3, ITPRIP, N0S2; 2342. CXCR1, MMP1, MMP2, 0DC1, IL6, ITPRIP; 2343. CXCR1, MMP1, MMP2, 0DC1, IL6, N0S2; 2344. CXCR1, MMP1, MMP2, 0DC1, ITPRIP, N0S2; 2345. CXCR1, MMP1, MMP2, IL6, ITPRIP, N0S2; 2346. CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3; 2347. CXCR1, MMP1,

[0429] 1985 CSF3, S100A12, SELE, 0DC1; 2348. CXCR1, MMP1, CSF3, S100A12, SELE, IL6; 2349. CXCR1, MMP1, CSF3, S100A12, SELE, ITPRIP; 2350. CXCR1, MMP1, CSF3, S100A12, SELE, N0S2; 2351. CXCR1, MMP1, CSF3, S100A12, HCAR3, 0DC1; 2352. CXCR1, MMP1, CSF3, S100A12, HCAR3, IL6; 2353. CXCR1, MMP1, CSF3, S100A12, HCAR3, ITPRIP; 2354. CXCR1, MMP1, CSF3, S100A12, HCAR3, N0S2; 2355. CXCR1, MMP1, CSF3, S100A12, 0DC1, IL6; 2356. CXCR1, MMP1, CSF3, S100A12, 0DC1, ITPRIP; 2357. CXCR1,

[0430] 1990 MMP1, CSF3, S100A12, 0DC1, N0S2; 2358. CXCR1, MMP1, CSF3, S100A12, IL6, ITPRIP; 2359. CXCR1, MMP1, CSF3, S100A12, IL6, N0S2; 2360. CXCR1, MMP1, CSF3, S100A12, ITPRIP, N0S2; 2361. CXCR1,

[0431] 51

[0432] 4935-6038-7201 , v. 2 MMP1, CSF3, SELE, HCAR3, ODC1; 2362. CXCR1, MMP1, CSF3, SELE, HCAR3, IL6; 2363. CXCR1, MMP1, CSF3, SELE, HCAR3, ITPRIP; 2364. CXCR1, MMP1, CSF3, SELE, HCAR3, N0S2; 2365. CXCR1, MMP1, CSF3, SELE, 0DC1, IL6; 2366. CXCR1, MMP1, CSF3, SELE, 0DC1, ITPRLP; 2367. CXCR1, MMP1,

[0433] 1995 CSF3, SELE, 0DC1, N0S2; 2368. CXCR1, MMP1, CSF3, SELE, IL6, ITPRLP; 2369. CXCR1, MMP1, CSF3, SELE, IL6, N0S2; 2370. CXCR1, MMP1, CSF3, SELE, ITPRLP, N0S2; 2371. CXCR1, MMP1, CSF3, HCAR3, 0DC1, IL6; 2372. CXCR1, MMP1, CSF3, HCAR3, 0DC1, ITPRLP; 2373. CXCR1, MMP1, CSF3, HCAR3, 0DC1, N0S2; 2374. CXCR1, MMP1, CSF3, HCAR3, IL6, ITPRLP; 2375. CXCR1, MMP1, CSF3, HCAR3, IL6, N0S2; 2376. CXCR1, MMP1, CSF3, HCAR3, ITPRLP, N0S2; 2377. CXCR1, MMP1, CSF3, 0DC1, IL6,

[0434] 2000 ITPRLP; 2378. CXCR1, MMP1, CSF3, 0DC1, IL6, N0S2; 2379. CXCR1, MMP1, CSF3, 0DC1, ITPRLP, N0S2; 2380. CXCR1, MMP1, CSF3, IL6, ITPRLP, N0S2; 2381. CXCR1, MMP1, S100A12, SELE, HCAR3, 0DC1; 2382. CXCR1, MMP1, S100A12, SELE, HCAR3, IL6; 2383. CXCR1, MMP1, S100A12, SELE, HCAR3, ITPRLP; 2384. CXCR1, MMP1, S100A12, SELE, HCAR3, N0S2; 2385. CXCR1, MMP1, S100A12, SELE, 0DC1, IL6; 2386. CXCR1, MMP1, S100A12, SELE, 0DC1, ITPRLP; 2387. CXCR1, MMP1, S100A12, SELE,

[0435] 2005 0DC1, N0S2; 2388. CXCR1, MMP1, S100A12, SELE, IL6, ITPRLP; 2389. CXCR1, MMP1, S100A12, SELE, IL6, N0S2; 2390. CXCR1, MMP1, S100A12, SELE, ITPRLP, N0S2; 2391. CXCR1, MMP1, S100A12, HCAR3, 0DC1, IL6; 2392. CXCR1, MMP1, S100A12, HCAR3, 0DC1, ITPRLP; 2393. CXCR1, MMP1, S100A12, HCAR3, 0DC1, N0S2; 2394. CXCR1, MMP1, S100A12, HCAR3, IL6, ITPRLP; 2395. CXCR1, MMP1, S100A12, HCAR3, IL6, N0S2; 2396. CXCR1, MMP1, S100A12, HCAR3, ITPRLP, N0S2; 2397. CXCR1,

[0436] 2010 MMP1, S100A12, 0DC1, IL6, ITPRLP; 2398. CXCR1, MMP1, S100A12, 0DC1, IL6, N0S2; 2399. CXCR1, MMP1, S100A12, 0DC1, ITPRLP, N0S2; 2400. CXCR1, MMP1, S100A12, IL6, ITPRLP, N0S2; 2401. CXCR1, MMP1, SELE, HCAR3, 0DC1, IL6; 2402. CXCR1, MMP1, SELE, HCAR3, 0DC1, ITPRLP; 2403. CXCR1, MMP1, SELE, HCAR3, 0DC1, N0S2; 2404. CXCR1, MMP1, SELE, HCAR3, IL6, ITPRLP; 2405. CXCR1, MMP1, SELE, HCAR3, IL6, N0S2; 2406. CXCR1, MMP1, SELE, HCAR3, ITPRLP, N0S2; 2407. CXCR1,

[0437] 2015 MMP1, SELE, 0DC1, IL6, ITPRLP; 2408. CXCR1, MMP1, SELE, 0DC1, IL6, N0S2; 2409. CXCR1, MMP1, SELE, 0DC1, ITPRLP, N0S2; 2410. CXCR1, MMP1, SELE, IL6, ITPRLP, N0S2; 2411. CXCR1, MMP1, HCAR3, 0DC1, IL6, ITPRLP; 2412. CXCR1, MMP1, HCAR3, 0DC1, IL6, N0S2; 2413. CXCR1, MMP1, HCAR3, 0DC1, ITPRLP, N0S2; 2414. CXCR1, MMP1, HCAR3, IL6, ITPRLP, N0S2; 2415. CXCR1, MMP1, 0DC1, IL6, ITPRLP, N0S2; 2416. CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3; 2417. CXCR1, MMP2,

[0438] 2020 CSF3, S100A12, SELE, 0DC1; 2418. CXCR1, MMP2, CSF3, S100A12, SELE, IL6; 2419. CXCR1, MMP2, CSF3, S100A12, SELE, ITPRLP; 2420. CXCR1, MMP2, CSF3, S100A12, SELE, N0S2; 2421. CXCR1, MMP2, CSF3, S100A12, HCAR3, 0DC1; 2422. CXCR1, MMP2, CSF3, S100A12, HCAR3, IL6; 2423. CXCR1, MMP2, CSF3, S100A12, HCAR3, ITPRLP; 2424. CXCR1, MMP2, CSF3, S100A12, HCAR3, N0S2; 2425. CXCR1, MMP2, CSF3, S100A12, 0DC1, IL6; 2426. CXCR1, MMP2, CSF3, S100A12, 0DC1, ITPRLP; 2427. CXCR1,

[0439] 2025 MMP2, CSF3, S100A12, 0DC1, N0S2; 2428. CXCR1, MMP2, CSF3, S100A12, IL6, ITPRLP; 2429. CXCR1, MMP2, CSF3, S100A12, IL6, N0S2; 2430. CXCR1, MMP2, CSF3, S100A12, ITPRLP, N0S2; 2431. CXCR1, MMP2, CSF3, SELE, HCAR3, 0DC1; 2432. CXCR1, MMP2, CSF3, SELE, HCAR3, IL6; 2433. CXCR1, MMP2, CSF3, SELE, HCAR3, ITPRLP; 2434. CXCR1, MMP2, CSF3, SELE, HCAR3, N0S2; 2435. CXCR1, MMP2, CSF3, SELE, 0DC1, IL6; 2436. CXCR1, MMP2, CSF3, SELE, 0DC1, ITPRLP; 2437. CXCR1, MMP2,

[0440] 2030 CSF3, SELE, 0DC1, N0S2; 2438. CXCR1, MMP2, CSF3, SELE, IL6, ITPRLP; 2439. CXCR1, MMP2, CSF3, SELE, IL6, N0S2; 2440. CXCR1, MMP2, CSF3, SELE, ITPRLP, N0S2; 2441. CXCR1, MMP2, CSF3, HCAR3,

[0441] 52

[0442] 4935-6038-7201 , v. 2 0DC1, IL6; 2442. CXCR1, MMP2, CSF3, HCAR3, 0DC1, ITPRLP; 2443. CXCR1, MMP2, CSF3, HCAR3, 0DC1, N0S2; 2444. CXCR1, MMP2, CSF3, HCAR3, IL6, ITPRIP; 2445. CXCR1, MMP2, CSF3, HCAR3, IL6, N0S2; 2446. CXCR1, MMP2, CSF3, HCAR3, ITPRIP, N0S2; 2447. CXCR1, MMP2, CSF3, 0DC1, IL6,

[0443] 2035 ITPRIP; 2448. CXCR1, MMP2, CSF3, 0DC1, IL6, N0S2; 2449. CXCR1, MMP2, CSF3, 0DC1, ITPRIP, N0S2; 2450. CXCR1, MMP2, CSF3, IL6, ITPRIP, N0S2; 2451. CXCR1, MMP2, S100A12, SELE, HCAR3, 0DC1; 2452. CXCR1, MMP2, S100A12, SELE, HCAR3, IL6; 2453. CXCR1, MMP2, S100A12, SELE, HCAR3, ITPRIP; 2454. CXCR1, MMP2, S100A12, SELE, HCAR3, N0S2; 2455. CXCR1, MMP2, S100A12, SELE, 0DC1, IL6; 2456. CXCR1, MMP2, S100A12, SELE, 0DC1, ITPRLP; 2457. CXCR1, MMP2, S100A12, SELE,

[0444] 2040 0DC1, N0S2; 2458. CXCR1, MMP2, S100A12, SELE, IL6, ITPRLP; 2459. CXCR1, MMP2, S100A12, SELE, IL6, N0S2; 2460. CXCR1, MMP2, S100A12, SELE, ITPRLP, N0S2; 2461. CXCR1, MMP2, S100A12, HCAR3, 0DC1, IL6; 2462. CXCR1, MMP2, S100A12, HCAR3, 0DC1, ITPRLP; 2463. CXCR1, MMP2, S100A12, HCAR3, 0DC1, N0S2; 2464. CXCR1, MMP2, S100A12, HCAR3, IL6, ITPRLP; 2465. CXCR1, MMP2, S100A12, HCAR3, IL6, N0S2; 2466. CXCR1, MMP2, S100A12, HCAR3, ITPRLP, N0S2; 2467. CXCR1,

[0445] 2045 MMP2, S100A12, 0DC1, IL6, ITPRLP; 2468. CXCR1, MMP2, S100A12, 0DC1, IL6, N0S2; 2469. CXCR1, MMP2, S100A12, 0DC1, ITPRLP, N0S2; 2470. CXCR1, MMP2, S100A12, IL6, ITPRLP, N0S2; 2471. CXCR1, MMP2, SELE, HCAR3, 0DC1, IL6; 2472. CXCR1, MMP2, SELE, HCAR3, 0DC1, ITPRLP; 2473. CXCR1, MMP2, SELE, HCAR3, 0DC1, N0S2; 2474. CXCR1, MMP2, SELE, HCAR3, IL6, ITPRLP; 2475. CXCR1, MMP2, SELE, HCAR3, IL6, N0S2; 2476. CXCR1, MMP2, SELE, HCAR3, ITPRLP, N0S2; 2477. CXCR1,

[0446] 2050 MMP2, SELE, 0DC1, IL6, ITPRLP; 2478. CXCR1, MMP2, SELE, 0DC1, IL6, N0S2; 2479. CXCR1, MMP2, SELE, 0DC1, ITPRLP, N0S2; 2480. CXCR1, MMP2, SELE, IL6, ITPRLP, N0S2; 2481. CXCR1, MMP2, HCAR3, 0DC1, IL6, ITPRLP; 2482. CXCR1, MMP2, HCAR3, 0DC1, IL6, N0S2; 2483. CXCR1, MMP2, HCAR3, 0DC1, ITPRLP, N0S2; 2484. CXCR1, MMP2, HCAR3, IL6, ITPRLP, N0S2; 2485. CXCR1, MMP2, 0DC1, IL6, ITPRLP, N0S2; 2486. CXCR1, CSF3, S100A12, SELE, HCAR3, 0DC1; 2487. CXCR1, CSF3,

[0447] 2055 S100A12, SELE, HCAR3, IL6; 2488. CXCR1, CSF3, S100A12, SELE, HCAR3, ITPRLP; 2489. CXCR1, CSF3, S100A12, SELE, HCAR3, N0S2; 2490. CXCR1, CSF3, S100A12, SELE, 0DC1, IL6; 2491. CXCR1, CSF3, S100A12, SELE, 0DC1, ITPRLP; 2492. CXCR1, CSF3, S100A12, SELE, 0DC1, N0S2; 2493. CXCR1, CSF3, S100A12, SELE, IL6, ITPRLP; 2494. CXCR1, CSF3, S100A12, SELE, IL6, N0S2; 2495. CXCR1, CSF3, S100A12, SELE, ITPRLP, N0S2; 2496. CXCR1, CSF3, S100A12, HCAR3, 0DC1, IL6; 2497. CXCR1, CSF3,

[0448] 2060 S100A12, HCAR3, 0DC1, ITPRLP; 2498. CXCR1, CSF3, S100A12, HCAR3, 0DC1, N0S2; 2499. CXCR1, CSF3, S100A12, HCAR3, IL6, ITPRLP; 2500. CXCR1, CSF3, S100A12, HCAR3, IL6, N0S2; 2501. CXCR1, CSF3, S100A12, HCAR3, ITPRLP, N0S2; 2502. CXCR1, CSF3, S100A12, 0DC1, IL6, ITPRLP; 2503. CXCR1, CSF3, S100A12, 0DC1, IL6, N0S2; 2504. CXCR1, CSF3, S100A12, 0DC1, ITPRLP, N0S2; 2505. CXCR1, CSF3, S100A12, IL6, ITPRLP, N0S2; 2506. CXCR1, CSF3, SELE, HCAR3, 0DC1, IL6; 2507. CXCR1, CSF3,

[0449] 2065 SELE, HCAR3, 0DC1, ITPRLP; 2508. CXCR1, CSF3, SELE, HCAR3, 0DC1, N0S2; 2509. CXCR1, CSF3, SELE, HCAR3, IL6, ITPRLP; 2510. CXCR1, CSF3, SELE, HCAR3, IL6, N0S2; 2511. CXCR1, CSF3, SELE, HCAR3, ITPRLP, N0S2; 2512. CXCR1, CSF3, SELE, 0DC1, IL6, ITPRLP; 2513. CXCR1, CSF3, SELE, 0DC1, IL6, N0S2; 2514. CXCR1, CSF3, SELE, 0DC1, ITPRLP, N0S2; 2515. CXCR1, CSF3, SELE, IL6, ITPRLP, N0S2; 2516. CXCR1, CSF3, HCAR3, 0DC1, IL6, ITPRLP; 2517. CXCR1, CSF3, HCAR3, 0DC1, IL6, N0S2;

[0450] 2070 2518. CXCR1, CSF3, HCAR3, 0DC1, ITPRLP, N0S2; 2519. CXCR1, CSF3, HCAR3, IL6, ITPRLP, N0S2;

[0451] 2520. CXCR1, CSF3, 0DC1, IL6, ITPRLP, N0S2; 2521. CXCR1, S100A12, SELE, HCAR3, 0DC1, IL6; 2522.

[0452] 53

[0453] 4935-6038-7201 , v. 2 CXCR1, S100A12, SELE, HCAR3, 0DC1, ITPRIP; 2523. CXCR1, S100A12, SELE, HCAR3, 0DC1, NOS2; 2524. CXCR1, S100A12, SELE, HCAR3, IL6, ITPRIP; 2525. CXCR1, S100A12, SELE, HCAR3, IL6, N0S2; 2526. CXCR1, S100A12, SELE, HCAR3, ITPRIP, N0S2; 2527. CXCR1, S100A12, SELE, 0DC1, IL6, ITPRIP;

[0454] 2075 2528. CXCR1, S100A12, SELE, 0DC1, IL6, N0S2; 2529. CXCR1, S100A12, SELE, 0DC1, ITPRIP, N0S2; 2530. CXCR1, S100A12, SELE, IL6, ITPRIP, N0S2; 2531. CXCR1, S100A12, HCAR3, 0DC1, IL6, ITPRIP; 2532. CXCR1, S100A12, HCAR3, 0DC1, IL6, N0S2; 2533. CXCR1, S100A12, HCAR3, 0DC1, ITPRIP, N0S2; 2534. CXCR1, S100A12, HCAR3, IL6, ITPRIP, N0S2; 2535. CXCR1, S100A12, 0DC1, IL6, ITPRIP, N0S2; 2536. CXCR1, SELE, HCAR3, 0DC1, IL6, ITPRIP; 2537. CXCR1, SELE, HCAR3, 0DC1, IL6, N0S2; 2538.

[0455] 2080 CXCR1, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 2539. CXCR1, SELE, HCAR3, IL6, ITPRIP, N0S2; 2540. CXCR1, SELE, 0DC1, IL6, ITPRIP, N0S2; 2541. CXCR1, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 2542. CCL4, MMP1, MMP2, CSF3, S100A12, SELE; 2543. CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3; 2544. CCL4, MMP1, MMP2, CSF3, S100A12, 0DC1; 2545. CCL4, MMP1, MMP2, CSF3, S100A12, IL6; 2546. CCL4, MMP1, MMP2, CSF3, S100A12, ITPRIP; 2547. CCL4, MMP1, MMP2, CSF3, S100A12, N0S2; 2548. CCL4,

[0456] 2085 MMP1, MMP2, CSF3, SELE, HCAR3; 2549. CCL4, MMP1, MMP2, CSF3, SELE, 0DC1; 2550. CCL4, MMP1, MMP2, CSF3, SELE, IL6; 2551. CCL4, MMP1, MMP2, CSF3, SELE, ITPRIP; 2552. CCL4, MMP1, MMP2, CSF3, SELE, N0S2; 2553. CCL4, MMP1, MMP2, CSF3, HCAR3, 0DC1; 2554. CCL4, MMP1, MMP2, CSF3, HCAR3, IL6; 2555. CCL4, MMP1, MMP2, CSF3, HCAR3, ITPRIP; 2556. CCL4, MMP1, MMP2, CSF3, HCAR3, N0S2; 2557. CCL4, MMP1, MMP2, CSF3, 0DC1, IL6; 2558. CCL4, MMP1, MMP2, CSF3, 0DC1,

[0457] 2090 ITPRIP; 2559. CCL4, MMP1, MMP2, CSF3, 0DC1, N0S2; 2560. CCL4, MMP1, MMP2, CSF3, IL6, ITPRIP; 2561. CCL4, MMP1, MMP2, CSF3, IL6, N0S2; 2562. CCL4, MMP1, MMP2, CSF3, ITPRIP, N0S2; 2563. CCL4, MMP1, MMP2, S100A12, SELE, HCAR3; 2564. CCL4, MMP1, MMP2, S100A12, SELE, 0DC1; 2565. CCL4, MMP1, MMP2, S100A12, SELE, IL6; 2566. CCL4, MMP1, MMP2, S100A12, SELE, ITPRIP; 2567.

[0458] CCL4, MMP1, MMP2, S100A12, SELE, N0S2; 2568. CCL4, MMP1, MMP2, S100A12, HCAR3, 0DC1; 2569.

[0459] 2095 CCL4, MMP1, MMP2, S100A12, HCAR3, IL6; 2570. CCL4, MMP1, MMP2, S100A12, HCAR3, ITPRIP; 2571. CCL4, MMP1, MMP2, S100A12, HCAR3, N0S2; 2572. CCL4, MMP1, MMP2, S100A12, 0DC1, IL6; 2573. CCL4, MMP1, MMP2, S100A12, 0DC1, ITPRIP; 2574. CCL4, MMP1, MMP2, S100A12, 0DC1, N0S2; 2575. CCL4, MMP1, MMP2, S100A12, IL6, ITPRIP; 2576. CCL4, MMP1, MMP2, S100A12, IL6, N0S2; 2577. CCL4, MMP1, MMP2, S100A12, ITPRIP, N0S2; 2578. CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1; 2579.

[0460] 2100 CCL4, MMP1, MMP2, SELE, HCAR3, IL6; 2580. CCL4, MMP1, MMP2, SELE, HCAR3, ITPRIP; 2581. CCL4, MMP1, MMP2, SELE, HCAR3, N0S2; 2582. CCL4, MMP1, MMP2, SELE, 0DC1, IL6; 2583. CCL4, MMP1, MMP2, SELE, 0DC1, ITPRIP; 2584. CCL4, MMP1, MMP2, SELE, 0DC1, N0S2; 2585. CCL4, MMP1, MMP2, SELE, IL6, ITPRIP; 2586. CCL4, MMP1, MMP2, SELE, IL6, N0S2; 2587. CCL4, MMP1, MMP2, SELE, ITPRIP, N0S2; 2588. CCL4, MMP1, MMP2, HCAR3, 0DC1, IL6; 2589. CCL4, MMP1, MMP2,

[0461] 2105 HCAR3, 0DC1, ITPRIP; 2590. CCL4, MMP1, MMP2, HCAR3, 0DC1, N0S2; 2591. CCL4, MMP1, MMP2, HCAR3, IL6, ITPRIP; 2592. CCL4, MMP1, MMP2, HCAR3, IL6, N0S2; 2593. CCL4, MMP1, MMP2, HCAR3, ITPRIP, N0S2; 2594. CCL4, MMP1, MMP2, 0DC1, IL6, ITPRIP; 2595. CCL4, MMP1, MMP2, 0DC1, IL6, N0S2; 2596. CCL4, MMP1, MMP2, 0DC1, ITPRIP, N0S2; 2597. CCL4, MMP1, MMP2, IL6, ITPRIP, N0S2; 2598. CCL4, MMP1, CSF3, S100A12, SELE, HCAR3; 2599. CCL4, MMP1, CSF3, S100A12, SELE, 0DC1;

[0462] 2110 2600. CCL4, MMP1, CSF3, S100A12, SELE, IL6; 2601. CCL4, MMP1, CSF3, S100A12, SELE, ITPRIP; 2602. CCL4, MMP1, CSF3, S100A12, SELE, N0S2; 2603. CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1; 2604.

[0463] 54

[0464] 4935-6038-7201 , v. 2 CCL4, MMP1, CSF3, S100A12, HCAR3, IL6; 2605. CCL4, MMP1, CSF3, S100A12, HCAR3, ITPRLP; 2606. CCL4, MMP1, CSF3, S100A12, HCAR3, N0S2; 2607. CCL4, MMP1, CSF3, S100A12, 0DC1, IL6; 2608. CCL4, MMP1, CSF3, S100A12, 0DC1, ITPRIP; 2609. CCL4, MMP1, CSF3, S100A12, 0DC1, N0S2; 2610.

[0465] 2115 CCL4, MMP1, CSF3, S100A12, IL6, ITPRIP; 2611. CCL4, MMP1, CSF3, S100A12, IL6, N0S2; 2612. CCL4, MMP1, CSF3, S100A12, ITPRIP, N0S2; 2613. CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1; 2614. CCL4, MMP1, CSF3, SELE, HCAR3, IL6; 2615. CCL4, MMP1, CSF3, SELE, HCAR3, ITPRLP; 2616. CCL4, MMP1, CSF3, SELE, HCAR3, N0S2; 2617. CCL4, MMP1, CSF3, SELE, 0DC1, IL6; 2618. CCL4, MMP1, CSF3, SELE, 0DC1, ITPRLP; 2619. CCL4, MMP1, CSF3, SELE, 0DC1, N0S2; 2620. CCL4, MMP1, CSF3, SELE,

[0466] 2120 IL6, ITPRLP; 2621. CCL4, MMP1, CSF3, SELE, IL6, N0S2; 2622. CCL4, MMP1, CSF3, SELE, ITPRLP, N0S2; 2623. CCL4, MMP1, CSF3, HCAR3, 0DC1, IL6; 2624. CCL4, MMP1, CSF3, HCAR3, 0DC1, ITPRLP; 2625. CCL4, MMP1, CSF3, HCAR3, 0DC1, N0S2; 2626. CCL4, MMP1, CSF3, HCAR3, IL6, ITPRLP; 2627. CCL4, MMP1, CSF3, HCAR3, IL6, N0S2; 2628. CCL4, MMP1, CSF3, HCAR3, ITPRLP, N0S2; 2629. CCL4, MMP1, CSF3, 0DC1, IL6, ITPRLP; 2630. CCL4, MMP1, CSF3, 0DC1, IL6, N0S2; 2631. CCL4, MMP1,

[0467] 2125 CSF3, 0DC1, ITPRLP, N0S2; 2632. CCL4, MMP1, CSF3, IL6, ITPRLP, N0S2; 2633. CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1; 2634. CCL4, MMP1, S100A12, SELE, HCAR3, IL6; 2635. CCL4, MMP1, S100A12, SELE, HCAR3, ITPRLP; 2636. CCL4, MMP1, S100A12, SELE, HCAR3, N0S2; 2637. CCL4, MMP1, S100A12, SELE, 0DC1, IL6; 2638. CCL4, MMP1, S100A12, SELE, 0DC1, ITPRLP; 2639. CCL4, MMP1, S100A12, SELE, 0DC1, N0S2; 2640. CCL4, MMP1, S100A12, SELE, IL6, ITPRLP; 2641. CCL4, MMP1, S100A12,

[0468] 2130 SELE, IL6, N0S2; 2642. CCL4, MMP1, S100A12, SELE, ITPRLP, N0S2; 2643. CCL4, MMP1, S100A12, HCAR3, 0DC1, IL6; 2644. CCL4, MMP1, S100A12, HCAR3, 0DC1, ITPRLP; 2645. CCL4, MMP1, S100A12, HCAR3, 0DC1, N0S2; 2646. CCL4, MMP1, S100A12, HCAR3, IL6, ITPRLP; 2647. CCL4, MMP1, S100A12, HCAR3, IL6, N0S2; 2648. CCL4, MMP1, S100A12, HCAR3, ITPRLP, N0S2; 2649. CCL4, MMP1, S100A12, 0DC1, IL6, ITPRLP; 2650. CCL4, MMP1, S100A12, 0DC1, IL6, N0S2; 2651. CCL4, MMP1, S100A12, 0DC1,

[0469] 2135 ITPRLP, N0S2; 2652. CCL4, MMP1, S100A12, IL6, ITPRLP, N0S2; 2653. CCL4, MMP1, SELE, HCAR3, 0DC1, IL6; 2654. CCL4, MMP1, SELE, HCAR3, 0DC1, ITPRLP; 2655. CCL4, MMP1, SELE, HCAR3, 0DC1, N0S2; 2656. CCL4, MMP1, SELE, HCAR3, IL6, ITPRLP; 2657. CCL4, MMP1, SELE, HCAR3, IL6, N0S2; 2658. CCL4, MMP1, SELE, HCAR3, ITPRLP, N0S2; 2659. CCL4, MMP1, SELE, 0DC1, IL6, ITPRLP; 2660. CCL4, MMP1, SELE, 0DC1, IL6, N0S2; 2661. CCL4, MMP1, SELE, 0DC1, ITPRLP, N0S2; 2662. CCL4,

[0470] 2140 MMP1, SELE, IL6, ITPRLP, N0S2; 2663. CCL4, MMP1, HCAR3, 0DC1, IL6, ITPRLP; 2664. CCL4, MMP1, HCAR3, 0DC1, IL6, N0S2; 2665. CCL4, MMP1, HCAR3, 0DC1, ITPRLP, N0S2; 2666. CCL4, MMP1, HCAR3, IL6, ITPRLP, N0S2; 2667. CCL4, MMP1, 0DC1, IL6, ITPRLP, N0S2; 2668. CCL4, MMP2, CSF3, S100A12, SELE, HCAR3; 2669. CCL4, MMP2, CSF3, S100A12, SELE, 0DC1; 2670. CCL4, MMP2, CSF3, S100A12, SELE, IL6; 2671. CCL4, MMP2, CSF3, S100A12, SELE, ITPRLP; 2672. CCL4, MMP2, CSF3,

[0471] 2145 S100A12, SELE, N0S2; 2673. CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1; 2674. CCL4, MMP2, CSF3, S100A12, HCAR3, IL6; 2675. CCL4, MMP2, CSF3, S100A12, HCAR3, ITPRLP; 2676. CCL4, MMP2, CSF3, S100A12, HCAR3, N0S2; 2677. CCL4, MMP2, CSF3, S100A12, 0DC1, IL6; 2678. CCL4, MMP2, CSF3, S100A12, 0DC1, ITPRLP; 2679. CCL4, MMP2, CSF3, S100A12, 0DC1, N0S2; 2680. CCL4, MMP2, CSF3, S100A12, IL6, ITPRLP; 2681. CCL4, MMP2, CSF3, S100A12, IL6, N0S2; 2682. CCL4, MMP2, CSF3,

[0472] 2150 S100A12, ITPRLP, N0S2; 2683. CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1; 2684. CCL4, MMP2, CSF3, SELE, HCAR3, IL6; 2685. CCL4, MMP2, CSF3, SELE, HCAR3, ITPRLP; 2686. CCL4, MMP2, CSF3, SELE,

[0473] 55

[0474] 4935-6038-7201 , v. 2 HCAR3, NOS2; 2687. CCL4, MMP2, CSF3, SELE, 0DC1, IL6; 2688. CCL4, MMP2, CSF3, SELE, 0DC1, ITPRLP; 2689. CCL4, MMP2, CSF3, SELE, 0DC1, N0S2; 2690. CCL4, MMP2, CSF3, SELE, IL6, ITPRLP; 2691. CCL4, MMP2, CSF3, SELE, IL6, N0S2; 2692. CCL4, MMP2, CSF3, SELE, ITPRLP, N0S2; 2693. CCL4,

[0475] 2155 MMP2, CSF3, HCAR3, 0DC1, IL6; 2694. CCL4, MMP2, CSF3, HCAR3, 0DC1, ITPRLP; 2695. CCL4, MMP2, CSF3, HCAR3, 0DC1, N0S2; 2696. CCL4, MMP2, CSF3, HCAR3, IL6, ITPRLP; 2697. CCL4, MMP2, CSF3, HCAR3, IL6, N0S2; 2698. CCL4, MMP2, CSF3, HCAR3, ITPRLP, N0S2; 2699. CCL4, MMP2, CSF3, 0DC1, IL6, ITPRLP; 2700. CCL4, MMP2, CSF3, 0DC1, IL6, N0S2; 2701. CCL4, MMP2, CSF3, 0DC1, ITPRLP, N0S2; 2702. CCL4, MMP2, CSF3, IL6, ITPRLP, N0S2; 2703. CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1;

[0476] 2160 2704. CCL4, MMP2, S100A12, SELE, HCAR3, IL6; 2705. CCL4, MMP2, S100A12, SELE, HCAR3, ITPRLP; 2706. CCL4, MMP2, S100A12, SELE, HCAR3, N0S2; 2707. CCL4, MMP2, S100A12, SELE, 0DC1, IL6; 2708. CCL4, MMP2, S100A12, SELE, 0DC1, ITPRLP; 2709. CCL4, MMP2, S100A12, SELE, 0DC1, N0S2; 2710. CCL4, MMP2, S100A12, SELE, IL6, ITPRLP; 2711. CCL4, MMP2, S100A12, SELE, IL6, N0S2; 2712. CCL4, MMP2, S100A12, SELE, ITPRLP, N0S2; 2713. CCL4, MMP2, S100A12, HCAR3, 0DC1, IL6; 2714. CCL4,

[0477] 2165 MMP2, S100A12, HCAR3, 0DC1, ITPRLP; 2715. CCL4, MMP2, S100A12, HCAR3, 0DC1, N0S2; 2716. CCL4, MMP2, S100A12, HCAR3, IL6, ITPRLP; 2717. CCL4, MMP2, S100A12, HCAR3, IL6, N0S2; 2718. CCL4, MMP2, S100A12, HCAR3, ITPRLP, N0S2; 2719. CCL4, MMP2, S100A12, 0DC1, IL6, ITPRLP; 2720. CCL4, MMP2, S100A12, 0DC1, IL6, N0S2; 2721. CCL4, MMP2, S100A12, 0DC1, ITPRLP, N0S2; 2722. CCL4, MMP2, S100A12, IL6, ITPRLP, N0S2; 2723. CCL4, MMP2, SELE, HCAR3, 0DC1, IL6; 2724. CCL4,

[0478] 2170 MMP2, SELE, HCAR3, 0DC1, ITPRLP; 2725. CCL4, MMP2, SELE, HCAR3, 0DC1, N0S2; 2726. CCL4, MMP2, SELE, HCAR3, IL6, ITPRLP; 2727. CCL4, MMP2, SELE, HCAR3, IL6, N0S2; 2728. CCL4, MMP2, SELE, HCAR3, ITPRLP, N0S2; 2729. CCL4, MMP2, SELE, 0DC1, IL6, ITPRLP; 2730. CCL4, MMP2, SELE, 0DC1, IL6, N0S2; 2731. CCL4, MMP2, SELE, 0DC1, ITPRLP, N0S2; 2732. CCL4, MMP2, SELE, IL6, ITPRLP, N0S2; 2733. CCL4, MMP2, HCAR3, 0DC1, IL6, ITPRLP; 2734. CCL4, MMP2, HCAR3, 0DC1, IL6,

[0479] 2175 N0S2; 2735. CCL4, MMP2, HCAR3, 0DC1, ITPRLP, N0S2; 2736. CCL4, MMP2, HCAR3, IL6, ITPRLP, N0S2; 2737. CCL4, MMP2, 0DC1, IL6, ITPRLP, N0S2; 2738. CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1; 2739. CCL4, CSF3, S100A12, SELE, HCAR3, IL6; 2740. CCL4, CSF3, S100A12, SELE, HCAR3, ITPRLP; 2741. CCL4, CSF3, S100A12, SELE, HCAR3, N0S2; 2742. CCL4, CSF3, S100A12, SELE, 0DC1, IL6; 2743. CCL4, CSF3, S100A12, SELE, 0DC1, ITPRLP; 2744. CCL4, CSF3, S100A12, SELE, 0DC1, N0S2; 2745.

[0480] 2180 CCL4, CSF3, S100A12, SELE, IL6, ITPRLP; 2746. CCL4, CSF3, S100A12, SELE, IL6, N0S2; 2747. CCL4, CSF3, S100A12, SELE, ITPRLP, N0S2; 2748. CCL4, CSF3, S100A12, HCAR3, 0DC1, IL6; 2749. CCL4, CSF3, S100A12, HCAR3, 0DC1, ITPRLP; 2750. CCL4, CSF3, S100A12, HCAR3, 0DC1, N0S2; 2751. CCL4, CSF3, S100A12, HCAR3, IL6, ITPRLP; 2752. CCL4, CSF3, S100A12, HCAR3, IL6, N0S2; 2753. CCL4, CSF3, S100A12, HCAR3, ITPRLP, N0S2; 2754. CCL4, CSF3, S100A12, 0DC1, IL6, ITPRLP; 2755. CCL4, CSF3,

[0481] 2185 S100A12, 0DC1, IL6, N0S2; 2756. CCL4, CSF3, S100A12, 0DC1, ITPRLP, N0S2; 2757. CCL4, CSF3, S100A12, IL6, ITPRLP, N0S2; 2758. CCL4, CSF3, SELE, HCAR3, 0DC1, IL6; 2759. CCL4, CSF3, SELE, HCAR3, 0DC1, ITPRLP; 2760. CCL4, CSF3, SELE, HCAR3, 0DC1, N0S2; 2761. CCL4, CSF3, SELE, HCAR3, IL6, ITPRLP; 2762. CCL4, CSF3, SELE, HCAR3, IL6, N0S2; 2763. CCL4, CSF3, SELE, HCAR3, ITPRLP, N0S2; 2764. CCL4, CSF3, SELE, 0DC1, IL6, ITPRLP; 2765. CCL4, CSF3, SELE, 0DC1, IL6, N0S2;

[0482] 2190 2766. CCL4, CSF3, SELE, 0DC1, ITPRLP, N0S2; 2767. CCL4, CSF3, SELE, IL6, ITPRLP, N0S2; 2768. CCL4, CSF3, HCAR3, 0DC1, IL6, ITPRLP; 2769. CCL4, CSF3, HCAR3, 0DC1, IL6, N0S2; 2770. CCL4, CSF3,

[0483] 56

[0484] 4935-6038-7201 , v. 2 HCAR3, 0DC1, ITPRLP, NOS2; 2771. CCL4, CSF3, HCAR3, IL6, ITPRLP, NOS2; 2772. CCL4, CSF3, 0DC1, IL6, ITPRIP, N0S2; 2773. CCL4, S100A12, SELE, HCAR3, 0DC1, IL6; 2774. CCL4, S100A12, SELE, HCAR3, 0DC1, ITPRIP; 2775. CCL4, S100A12, SELE, HCAR3, 0DC1, N0S2; 2776. CCL4, S100A12, SELE, HCAR3,

[0485] 2195 IL6, ITPRIP; 2777. CCL4, S100A12, SELE, HCAR3, IL6, N0S2; 2778. CCL4, S100A12, SELE, HCAR3, ITPRIP, N0S2; 2779. CCL4, S100A12, SELE, 0DC1, IL6, ITPRLP; 2780. CCL4, S100A12, SELE, 0DC1, IL6, N0S2; 2781. CCL4, S100A12, SELE, 0DC1, ITPRLP, N0S2; 2782. CCL4, S100A12, SELE, IL6, ITPRLP, N0S2; 2783. CCL4, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 2784. CCL4, S100A12, HCAR3, 0DC1, IL6, N0S2; 2785. CCL4, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 2786. CCL4, S100A12, HCAR3, IL6, ITPRLP,

[0486] 2200 N0S2; 2787. CCL4, S100A12, 0DC1, IL6, ITPRLP, N0S2; 2788. CCL4, SELE, HCAR3, 0DC1, IL6, ITPRLP; 2789. CCL4, SELE, HCAR3, 0DC1, IL6, N0S2; 2790. CCL4, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 2791. CCL4, SELE, HCAR3, IL6, ITPRLP, N0S2; 2792. CCL4, SELE, 0DC1, IL6, ITPRLP, N0S2; 2793. CCL4, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 2794. MMP1, MMP2, CSF3, S100A12, SELE, HCAR3; 2795. MMP1, MMP2, CSF3, S100A12, SELE, 0DC1; 2796. MMP1, MMP2, CSF3, S100A12, SELE, IL6; 2797. MMP1,

[0487] 2205 MMP2, CSF3, S100A12, SELE, ITPRLP; 2798. MMP1, MMP2, CSF3, S100A12, SELE, N0S2; 2799. MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1; 2800. MMP1, MMP2, CSF3, S100A12, HCAR3, IL6; 2801. MMP1, MMP2, CSF3, S100A12, HCAR3, ITPRLP; 2802. MMP1, MMP2, CSF3, S100A12, HCAR3, N0S2; 2803. MMP1, MMP2, CSF3, S100A12, 0DC1, IL6; 2804. MMP1, MMP2, CSF3, S100A12, 0DC1, ITPRLP; 2805. MMP1, MMP2, CSF3, S100A12, 0DC1, N0S2; 2806. MMP1, MMP2, CSF3, S100A12, IL6, ITPRLP; 2807.

[0488] 2210 MMP1, MMP2, CSF3, S100A12, IL6, N0S2; 2808. MMP1, MMP2, CSF3, S100A12, ITPRLP, N0S2; 2809. MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1; 2810. MMP1, MMP2, CSF3, SELE, HCAR3, IL6; 2811. MMP1, MMP2, CSF3, SELE, HCAR3, ITPRLP; 2812. MMP1, MMP2, CSF3, SELE, HCAR3, N0S2; 2813. MMP1, MMP2, CSF3, SELE, 0DC1, IL6; 2814. MMP1, MMP2, CSF3, SELE, 0DC1, ITPRLP; 2815. MMP1, MMP2, CSF3, SELE, 0DC1, N0S2; 2816. MMP1, MMP2, CSF3, SELE, IL6, ITPRLP; 2817. MMP1, MMP2, CSF3,

[0489] 2215 SELE, IL6, N0S2; 2818. MMP1, MMP2, CSF3, SELE, ITPRLP, N0S2; 2819. MMP1, MMP2, CSF3, HCAR3, 0DC1, IL6; 2820. MMP1, MMP2, CSF3, HCAR3, 0DC1, ITPRLP; 2821. MMP1, MMP2, CSF3, HCAR3, 0DC1, N0S2; 2822. MMP1, MMP2, CSF3, HCAR3, IL6, ITPRLP; 2823. MMP1, MMP2, CSF3, HCAR3, IL6, N0S2; 2824. MMP1, MMP2, CSF3, HCAR3, ITPRLP, N0S2; 2825. MMP1, MMP2, CSF3, 0DC1, IL6, ITPRLP; 2826. MMP1, MMP2, CSF3, 0DC1, IL6, N0S2; 2827. MMP1, MMP2, CSF3, 0DC1, ITPRLP, N0S2;

[0490] 2220 2828. MMP1, MMP2, CSF3, IL6, ITPRLP, N0S2; 2829. MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1; 2830. MMP1, MMP2, S100A12, SELE, HCAR3, IL6; 2831. MMP1, MMP2, S100A12, SELE, HCAR3, ITPRLP; 2832. MMP1, MMP2, S100A12, SELE, HCAR3, N0S2; 2833. MMP1, MMP2, S100A12, SELE, 0DC1, IL6; 2834. MMP1, MMP2, S100A12, SELE, 0DC1, ITPRLP; 2835. MMP1, MMP2, S100A12, SELE, 0DC1, N0S2; 2836. MMP1, MMP2, S100A12, SELE, IL6, ITPRLP; 2837. MMP1, MMP2, S100A12, SELE, IL6, N0S2; 2838.

[0491] 2225 MMP1, MMP2, S100A12, SELE, ITPRLP, N0S2; 2839. MMP1, MMP2, S100A12, HCAR3, 0DC1, IL6; 2840. MMP1, MMP2, S100A12, HCAR3, 0DC1, ITPRLP; 2841. MMP1, MMP2, S100A12, HCAR3, 0DC1, N0S2; 2842. MMP1, MMP2, S100A12, HCAR3, IL6, ITPRLP; 2843. MMP1, MMP2, S100A12, HCAR3, IL6, N0S2; 2844. MMP1, MMP2, S100A12, HCAR3, ITPRLP, N0S2; 2845. MMP1, MMP2, S100A12, 0DC1, IL6, ITPRLP; 2846. MMP1, MMP2, S100A12, 0DC1, IL6, N0S2; 2847. MMP1, MMP2, S100A12, 0DC1, ITPRLP, N0S2;

[0492] 2230 2848. MMP1, MMP2, S100A12, IL6, ITPRLP, N0S2; 2849. MMP1, MMP2, SELE, HCAR3, 0DC1, IL6; 2850. MMP1, MMP2, SELE, HCAR3, 0DC1, ITPRLP; 2851. MMP1, MMP2, SELE, HCAR3, 0DC1, N0S2; 2852.

[0493] 57

[0494] 4935-6038-7201 , v. 2 MMP1, MMP2, SELE, HCAR3, IL6, ITPRIP; 2853. MMP1, MMP2, SELE, HCAR3, IL6, NOS2; 2854. MMP1, MMP2, SELE, HCAR3, ITPRIP, N0S2; 2855. MMP1, MMP2, SELE, 0DC1, IL6, ITPRIP; 2856. MMP1, MMP2, SELE, 0DC1, IL6, N0S2; 2857. MMP1, MMP2, SELE, 0DC1, ITPRIP, N0S2; 2858. MMP1, MMP2,

[0495] 2235 SELE, IL6, ITPRIP, N0S2; 2859. MMP1, MMP2, HCAR3, 0DC1, IL6, ITPRIP; 2860. MMP1, MMP2, HCAR3, 0DC1, IL6, N0S2; 2861. MMP1, MMP2, HCAR3, 0DC1, ITPRIP, N0S2; 2862. MMP1, MMP2, HCAR3, IL6, ITPRIP, N0S2; 2863. MMP1, MMP2, 0DC1, IL6, ITPRIP, N0S2; 2864. MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1; 2865. MMP1, CSF3, S100A12, SELE, HCAR3, IL6; 2866. MMP1, CSF3, S100A12, SELE, HCAR3, ITPRIP; 2867. MMP1, CSF3, S100A12, SELE, HCAR3, N0S2; 2868. MMP1, CSF3, S100A12, SELE,

[0496] 2240 0DC1, IL6; 2869. MMP1, CSF3, S100A12, SELE, 0DC1, ITPRIP; 2870. MMP1, CSF3, S100A12, SELE, 0DC1, N0S2; 2871. MMP1, CSF3, S100A12, SELE, IL6, ITPRIP; 2872. MMP1, CSF3, S100A12, SELE, IL6, N0S2; 2873. MMP1, CSF3, S100A12, SELE, ITPRIP, N0S2; 2874. MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6; 2875. MMP1, CSF3, S100A12, HCAR3, 0DC1, ITPRIP; 2876. MMP1, CSF3, S100A12, HCAR3, 0DC1, N0S2; 2877. MMP1, CSF3, S100A12, HCAR3, IL6, ITPRIP; 2878. MMP1, CSF3, S100A12, HCAR3, IL6,

[0497] 2245 N0S2; 2879. MMP1, CSF3, S100A12, HCAR3, ITPRIP, N0S2; 2880. MMP1, CSF3, S100A12, 0DC1, IL6, ITPRIP; 2881. MMP1, CSF3, S100A12, 0DC1, IL6, N0S2; 2882. MMP1, CSF3, S100A12, 0DC1, ITPRIP, N0S2; 2883. MMP1, CSF3, S100A12, IL6, ITPRIP, N0S2; 2884. MMP1, CSF3, SELE, HCAR3, 0DC1, IL6; 2885. MMP1, CSF3, SELE, HCAR3, 0DC1, ITPRIP; 2886. MMP1, CSF3, SELE, HCAR3, 0DC1, N0S2; 2887. MMP1, CSF3, SELE, HCAR3, IL6, ITPRIP; 2888. MMP1, CSF3, SELE, HCAR3, IL6, N0S2; 2889. MMP1,

[0498] 2250 CSF3, SELE, HCAR3, ITPRIP, N0S2; 2890. MMP1, CSF3, SELE, 0DC1, IL6, ITPRIP; 2891. MMP1, CSF3, SELE, 0DC1, IL6, N0S2; 2892. MMP1, CSF3, SELE, 0DC1, ITPRIP, N0S2; 2893. MMP1, CSF3, SELE, IL6, ITPRIP, N0S2; 2894. MMP1, CSF3, HCAR3, 0DC1, IL6, ITPRIP; 2895. MMP1, CSF3, HCAR3, 0DC1, IL6, N0S2; 2896. MMP1, CSF3, HCAR3, 0DC1, ITPRIP, N0S2; 2897. MMP1, CSF3, HCAR3, IL6, ITPRIP, N0S2; 2898. MMP1, CSF3, 0DC1, IL6, ITPRIP, N0S2; 2899. MMP1, S100A12, SELE, HCAR3, 0DC1, IL6;

[0499] 2255 2900. MMP1, S100A12, SELE, HCAR3, 0DC1, ITPRIP; 2901. MMP1, S100A12, SELE, HCAR3, 0DC1, N0S2; 2902. MMP1, S100A12, SELE, HCAR3, IL6, ITPRIP; 2903. MMP1, S100A12, SELE, HCAR3, IL6, N0S2; 2904. MMP1, S100A12, SELE, HCAR3, ITPRIP, N0S2; 2905. MMP1, S100A12, SELE, 0DC1, IL6, ITPRIP; 2906. MMP1, S100A12, SELE, 0DC1, IL6, N0S2; 2907. MMP1, S100A12, SELE, 0DC1, ITPRIP, N0S2; 2908. MMP1, S100A12, SELE, IL6, ITPRIP, N0S2; 2909. MMP1, S100A12, HCAR3, 0DC1, IL6,

[0500] 2260 ITPRIP; 2910. MMP1, S100A12, HCAR3, 0DC1, IL6, N0S2; 2911. MMP1, S100A12, HCAR3, 0DC1, ITPRIP, N0S2; 2912. MMP1, S100A12, HCAR3, IL6, ITPRIP, N0S2; 2913. MMP1, S100A12, 0DC1, IL6, ITPRIP, N0S2; 2914. MMP1, SELE, HCAR3, 0DC1, IL6, ITPRIP; 2915. MMP1, SELE, HCAR3, 0DC1, IL6, N0S2; 2916. MMP1, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 2917. MMP1, SELE, HCAR3, IL6, ITPRIP, N0S2; 2918. MMP1, SELE, 0DC1, IL6, ITPRIP, N0S2; 2919. MMP1, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 2920. MMP2,

[0501] 2265 CSF3, S100A12, SELE, HCAR3, 0DC1; 2921. MMP2, CSF3, S100A12, SELE, HCAR3, IL6; 2922. MMP2, CSF3, S100A12, SELE, HCAR3, ITPRIP; 2923. MMP2, CSF3, S100A12, SELE, HCAR3, N0S2; 2924. MMP2, CSF3, S100A12, SELE, 0DC1, IL6; 2925. MMP2, CSF3, S100A12, SELE, 0DC1, ITPRIP; 2926. MMP2, CSF3, S100A12, SELE, 0DC1, N0S2; 2927. MMP2, CSF3, S100A12, SELE, IL6, ITPRIP; 2928. MMP2, CSF3, S100A12, SELE, IL6, N0S2; 2929. MMP2, CSF3, S100A12, SELE, ITPRIP, N0S2; 2930. MMP2, CSF3,

[0502] 2270 S100A12, HCAR3, 0DC1, IL6; 2931. MMP2, CSF3, S100A12, HCAR3, 0DC1, ITPRIP; 2932. MMP2, CSF3, S100A12, HCAR3, 0DC1, N0S2; 2933. MMP2, CSF3, S100A12, HCAR3, IL6, ITPRIP; 2934. MMP2, CSF3,

[0503] 58

[0504] 4935-6038-7201 , v. 2 S100A12, HCAR3, IL6, NOS2; 2935. MMP2, CSF3, S100A12, HCAR3, ITPRLP, NOS2; 2936. MMP2, CSF3, S100A12, 0DC1, IL6, ITPRIP; 2937. MMP2, CSF3, S100A12, 0DC1, IL6, N0S2; 2938. MMP2, CSF3, S100A12, 0DC1, ITPRIP, N0S2; 2939. MMP2, CSF3, S100A12, IL6, ITPRIP, N0S2; 2940. MMP2, CSF3,

[0505] 2275 SELE, HCAR3, 0DC1, IL6; 2941. MMP2, CSF3, SELE, HCAR3, 0DC1, ITPRIP; 2942. MMP2, CSF3, SELE, HCAR3, 0DC1, N0S2; 2943. MMP2, CSF3, SELE, HCAR3, IL6, ITPRLP; 2944. MMP2, CSF3, SELE, HCAR3, IL6, N0S2; 2945. MMP2, CSF3, SELE, HCAR3, ITPRLP, N0S2; 2946. MMP2, CSF3, SELE, 0DC1, IL6, ITPRLP; 2947. MMP2, CSF3, SELE, 0DC1, IL6, N0S2; 2948. MMP2, CSF3, SELE, 0DC1, ITPRLP, N0S2; 2949. MMP2, CSF3, SELE, IL6, ITPRLP, N0S2; 2950. MMP2, CSF3, HCAR3, 0DC1, IL6, ITPRLP; 2951.

[0506] 2280 MMP2, CSF3, HCAR3, 0DC1, IL6, N0S2; 2952. MMP2, CSF3, HCAR3, 0DC1, ITPRLP, N0S2; 2953. MMP2, CSF3, HCAR3, IL6, ITPRLP, N0S2; 2954. MMP2, CSF3, 0DC1, IL6, ITPRLP, N0S2; 2955. MMP2, S100A12, SELE, HCAR3, 0DC1, IL6; 2956. MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 2957. MMP2, S100A12, SELE, HCAR3, 0DC1, N0S2; 2958. MMP2, S100A12, SELE, HCAR3, IL6, ITPRLP; 2959. MMP2, S100A12, SELE, HCAR3, IL6, N0S2; 2960. MMP2, S100A12, SELE, HCAR3, ITPRLP, N0S2; 2961. MMP2, S100A12,

[0507] 2285 SELE, 0DC1, IL6, ITPRLP; 2962. MMP2, S100A12, SELE, 0DC1, IL6, N0S2; 2963. MMP2, S100A12, SELE, 0DC1, ITPRLP, N0S2; 2964. MMP2, S100A12, SELE, IL6, ITPRLP, N0S2; 2965. MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 2966. MMP2, S100A12, HCAR3, 0DC1, IL6, N0S2; 2967. MMP2, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 2968. MMP2, S100A12, HCAR3, IL6, ITPRLP, N0S2; 2969. MMP2, S100A12, 0DC1, IL6, ITPRLP, N0S2; 2970. MMP2, SELE, HCAR3, 0DC1, IL6, ITPRLP; 2971. MMP2, SELE, HCAR3, 0DC1,

[0508] 2290 IL6, N0S2; 2972. MMP2, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 2973. MMP2, SELE, HCAR3, IL6, ITPRLP, N0S2; 2974. MMP2, SELE, 0DC1, IL6, ITPRLP, N0S2; 2975. MMP2, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 2976. CSF3, S100A12, SELE, HCAR3, 0DC1, IL6; 2977. CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 2978. CSF3, S100A12, SELE, HCAR3, 0DC1, N0S2; 2979. CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP; 2980. CSF3, S100A12, SELE, HCAR3, IL6, N0S2; 2981. CSF3, S100A12, SELE, HCAR3, ITPRLP, N0S2;

[0509] 2295 2982. CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP; 2983. CSF3, S100A12, SELE, 0DC1, IL6, N0S2; 2984.

[0510] CSF3, S100A12, SELE, 0DC1, ITPRLP, N0S2; 2985. CSF3, S100A12, SELE, IL6, ITPRLP, N0S2; 2986. CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 2987. CSF3, S100A12, HCAR3, 0DC1, IL6, N0S2; 2988. CSF3, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 2989. CSF3, S100A12, HCAR3, IL6, ITPRLP, N0S2; 2990. CSF3, S100A12, 0DC1, IL6, ITPRLP, N0S2; 2991. CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP; 2992. CSF3, SELE,

[0511] 2300 HCAR3, 0DC1, IL6, N0S2; 2993. CSF3, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 2994. CSF3, SELE, HCAR3, IL6, ITPRLP, N0S2; 2995. CSF3, SELE, 0DC1, IL6, ITPRLP, N0S2; 2996. CSF3, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 2997. S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 2998. S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 2999. S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 3000. S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 3001. S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 3002. S100A12, HCAR3, 0DC1, IL6,

[0512] 2305 ITPRLP, N0S2; and 3003. SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2. Collectively, the above genes are referred to as " selBM comb list". In embodiments, ; each gene 1-3003 of "selBM comb list" is used individually, e.g., as part of, or the entirety of, a gene panel (e.g., a gene panel of 50-100 markers). The above selBM comb list is understood to be used in any of the methods described herein, such as part of a patient treatment regimen, such as part of a gene panel.

[0513] 2310 Embodiments of the present disclosure include methods for treating a subject with an inflammatory bowel disease (or other indications disclosed herein), the methods including obtaining a biological sample from

[0514] 59

[0515] 4935-6038-7201 , v. 2 the subject with the, e.g., inflammatory bowel disease; and measuring gene expression levels of a larger number of genes, as part of a gene panel. In embodiments, the measured genes can include the following genes:

[0516] 1. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODCE, 2.

[0517] 2315 DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6; 3. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ITPRLP; 4. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, NOS2; 5. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, IL6; 6. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, ITPRLP; 7. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3,

[0518] 2320 S100A12, SELE, ODC1, NOS2; 8. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, IL6, ITPRLP; 9. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, IL6, NOS2; 10. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ITPRLP, NOS2; 11. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, IL6; 12. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, ITPRLP; 13. DU0XA2, LUCAT1, CXCR1,

[0519] 2325 CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, NOS2; 14. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, ITPRLP; 15. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, NOS2; 16. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ITPRLP, NOS2; 17. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, ODC1, IL6, ITPRLP; 18. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, ODC1, IL6,

[0520] 2330 NOS2; 19. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, ODC1, ITPRLP, NOS2; 20. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, IL6, ITPRLP, NOS2; 21. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, IL6; 22. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, ITPRLP; 23. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, NOS2; 24. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3,

[0521] 2335 SELE, HCAR3, IL6, ITPRLP; 25. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, IL6, NOS2; 26. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ITPRLP, NOS2; 27. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, ODC1, IL6, ITPRLP; 28. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, ODC1, IL6, NOS2; 29. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, ODC1, ITPRLP, NOS2; 30. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1,

[0522] 2340 MMP2, CSF3, SELE, IL6, ITPRLP, NOS2; 31. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, ODC1, IL6, ITPRLP; 32. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, ODC1, IL6, NOS2; 33. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, ODC1, ITPRLP, NOS2;

[0523] 60

[0524] 4935-6038-7201 , v. 2 34. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, IL6, ITPRLP, NOS2; 35. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, 0DC1, IL6, ITPRIP, N0S2; 36. DU0XA2, LUCAT1, CXCR1,

[0525] 2345 CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6; 37. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRIP; 38. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, N0S2; 39. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, ITPRLP; 40. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, N0S2; 41. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3,

[0526] 2350 ITPRLP, N0S2; 42. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, 0DC1, IL6, ITPRLP; 43. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, 0DC1, IL6, N0S2; 44. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, 0DC1, ITPRLP, N0S2; 45. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, IL6, ITPRLP, N0S2; 46. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 47. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1,

[0527] 2355 MMP2, S100A12, HCAR3, 0DC1, IL6, N0S2; 48. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 49. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3, IL6, ITPRLP, N0S2; 50. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, 0DC1, IL6, ITPRLP, N0S2; 51. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1, IL6, ITPRLP; 52. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1, IL6, N0S2; 53. DU0XA2,

[0528] 2360 LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 54. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, IL6, ITPRLP, N0S2; 55. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, 0DC1, IL6, ITPRLP, N0S2; 56. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 57. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6; 58. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1,

[0529] 2365 ITPRLP; 59. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, N0S2; 60. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP; 61. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, IL6, N0S2; 62. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, ITPRLP, N0S2; 63. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP; 64. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1,

[0530] 2370 CSF3, S100A12, SELE, 0DC1, IL6, N0S2; 65. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, 0DC1, ITPRLP, N0S2; 66. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, IL6, ITPRLP, N0S2; 67. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 68. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6, N0S2; 69.

[0531] 61

[0532] 4935-6038-7201 , v. 2 DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1, ITPRLP, NOS2; 70. DU0XA2,

[0533] 2375 LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, IL6, ITPRIP, N0S2; 71. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, 0DC1, IL6, ITPRIP, N0S2; 72. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP; 73. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, N0S2; 74. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 75. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, IL6, ITPRLP,

[0534] 2380 N0S2; 76. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, 0DC1, IL6, ITPRLP, N0S2; 77. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 78. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 79. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 80. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 81. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1,

[0535] 2385 S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 82. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 83. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 84. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 85. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6; 86. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 87. DU0XA2,

[0536] 2390 LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, N0S2; 88. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP; 89. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, N0S2; 90. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, ITPRLP, N0S2; 91. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP; 92. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1,

[0537] 2395 IL6, N0S2; 93. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1, ITPRLP, N0S2; 94. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, IL6, ITPRLP, N0S2; 95. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 96. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, N0S2; 97. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 98. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2,

[0538] 2400 CSF3, S100A12, HCAR3, IL6, ITPRLP, N0S2; 99. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, 0DC1, IL6, ITPRLP, N0S2; 100. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP; 101. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, N0S2; 102. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 103. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, IL6, ITPRLP, N0S2; 104. DU0XA2,

[0539] 62

[0540] 4935-6038-7201 , v. 2 2405 LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, 0DC1, IL6, ITPRLP, NOS2; 105. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 106. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 107. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 108. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 109. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, IL6,

[0541] 2410 ITPRIP, N0S2; 110. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 111. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 112. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 113. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 114. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 115. DU0XA2, LUCAT1, CXCR1, CCL4,

[0542] 2415 CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 116. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 117. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 118. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 119. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 120. DU0XA2, LUCAT1, CXCR1, CCL4, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 121.

[0543] 2420 DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6; 122. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 123. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, N0S2; 124. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP; 125. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, N0S2; 126. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3,

[0544] 2425 S100A12, SELE, HCAR3, ITPRLP, N0S2; 127. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP; 128. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, N0S2; 129. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, ITPRLP, N0S2; 130. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, IL6, ITPRLP, N0S2; 131. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 132. DU0XA2, LUCAT1,

[0545] 2430 CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, N0S2; 133. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 134. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, ITPRLP, N0S2; 135. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, 0DC1, IL6, ITPRLP, N0S2; 136. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP; 137. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1,

[0546] 2435 IL6, N0S2; 138. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, ITPRLP, N0S2;

[0547] 63

[0548] 4935-6038-7201 , v. 2 139. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, IL6, ITPRIP, NOS2; 140. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, 0DC1, IL6, ITPRIP, N0S2; 141. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 142. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 143. DU0XA2, LUCAT1, CXCR1, MMP1,

[0549] 2440 MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 144. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 145. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 146. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 147. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 148. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2;

[0550] 2445 149. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 150.

[0551] DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 151. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 152. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 153. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 154. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3,

[0552] 2450 S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 155. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 156. DU0XA2, LUCAT1, CXCR1, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 157. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 158. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 159. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 160.

[0553] 2455 DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 161. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 162. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 163. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 164. DU0XA2, LUCAT1, CXCR1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 165. DU0XA2, LUCAT1, CXCR1, CSF3, S100A12,

[0554] 2460 SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 166. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6; 167. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP; 168. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, N0S2; 169. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP; 170. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, N0S2; 171. DU0XA2,

[0555] 2465 LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ITPRIP, N0S2; 172. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP; 173. DU0XA2, LUCAT1, CCL4, MMP1,

[0556] 64

[0557] 4935-6038-7201 , v. 2 MMP2, CSF3, S100A12, SELE, 0DC1, IL6, NOS2; 174. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, ITPRLP, N0S2; 175. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, IL6, ITPRLP, N0S2; 176. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1,

[0558] 2470 IL6, ITPRLP; 177. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, N0S2; 178. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, ITPRLP, N0S2; 179. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, ITPRLP, N0S2; 180. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, 0DC1, IL6, ITPRLP, N0S2; 181. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP; 182. DU0XA2, LUCAT1, CCL4, MMP1,

[0559] 2475 MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, N0S2; 183. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 184. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, IL6, ITPRLP, N0S2; 185. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE, 0DC1, IL6, ITPRLP, N0S2; 186. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 187. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 188. DU0XA2,

[0560] 2480 LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 189. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 190. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 191. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 192. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 193. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, SELE,

[0561] 2485 HCAR3, 0DC1, IL6, ITPRLP, N0S2; 194. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 195. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 196. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 197. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 198. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 199. DU0XA2, LUCAT1, CCL4,

[0562] 2490 MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 200. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 201. DU0XA2, LUCAT1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 202. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 203. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 204. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 205.

[0563] 2495 DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 206. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 207. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 208. DU0XA2, LUCAT1, CCL4, MMP2, CSF3,

[0564] 65

[0565] 4935-6038-7201 , v. 2 SELE, HCAR3, 0DC1, IL6, ITPRLP, NOS2; 209. DU0XA2, LUCAT1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 210. DU0XA2, LUCAT1, CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6,

[0566] 2500 ITPRIP, N0S2; 211. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 212. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 213. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 214. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 215. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 216. DU0XA2, LUCAT1, MMP1, MMP2,

[0567] 2505 CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 217. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 218. DU0XA2, LUCAT1, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 219. DU0XA2, LUCAT1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 220. DU0XA2, LUCAT1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 221. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6; 222. DU0XA2,

[0568] 2510 CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP; 223. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, N0S2; 224. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP; 225. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, N0S2; 226. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ITPRLP, N0S2; 227. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6,

[0569] 2515 ITPRLP; 228. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, N0S2; 229. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, ITPRLP, N0S2; 230. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, IL6, ITPRLP, N0S2; 231. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP; 232. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, N0S2; 233. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12,

[0570] 2520 HCAR3, 0DC1, ITPRLP, N0S2; 234. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, ITPRLP, N0S2; 235. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, 0DC1, IL6, ITPRLP, N0S2; 236. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP; 237. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, N0S2; 238. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 239. DU0XA2, CXCR1, CCL4, MMP1, MMP2,

[0571] 2525 CSF3, SELE, HCAR3, IL6, ITPRLP, N0S2; 240. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, 0DC1, IL6, ITPRLP, N0S2; 241. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 242. DU0XA2, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 243. DU0XA2, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 244. DU0XA2,

[0572] 66

[0573] 4935-6038-7201 , v. 2 CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRIP, NOS2; 245. DU0XA2, CXCR1,

[0574] 2530 CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 246. DU0XA2, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 247. DU0XA2, CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 248. DU0XA2, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 249. DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 250. DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 251.

[0575] 2535 DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 252. DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 253. DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 254. DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 255. DU0XA2, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 256. DU0XA2, CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6,

[0576] 2540 ITPRIP, N0S2; 257. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 258. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 259. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 260. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 261. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 262. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12,

[0577] 2545 HCAR3, 0DC1, IL6, ITPRIP, N0S2; 263. DU0XA2, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 264. DU0XA2, CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 265. DU0XA2, CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 266. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 267. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 268. DU0XA2, CXCR1, MMP1,

[0578] 2550 MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 269. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 270. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 271. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 272. DU0XA2, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 273. DU0XA2, CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 274.

[0579] 2555 DU0XA2, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 275. DU0XA2, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 276. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 277. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 278. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 279. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6,

[0580] 67

[0581] 4935-6038-7201 , v. 2 2560 ITPRLP, NOS2; 280. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, NOS2;

[0582] 281. DUOXA2, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, IL6, ITPRIP, NOS2; 282. DUOXA2, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, IL6, ITPRIP, NOS2; 283. DUOXA2, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 284. DUOXA2, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 285. DUOXA2, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3,

[0583] 2565 ODC1, IL6, ITPRLP, NOS2; 286. DUOXA2, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 287. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6; 288. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, ITPRLP; 289. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, NOS2; 290. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP; 291. LUCAT1, CXCR1, CCL4, MMP1, MMP2,

[0584] 2570 CSF3, S100A12, SELE, HCAR3, IL6, NOS2; 292. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ITPRLP, NOS2; 293. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, IL6, ITPRLP; 294. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, IL6, NOS2; 295. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, ITPRLP, NOS2; 296. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, IL6, ITPRLP, NOS2; 297. LUCAT1, CXCR1, CCL4,

[0585] 2575 MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, IL6, ITPRLP; 298. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, IL6, NOS2; 299. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, ITPRLP, NOS2; 300. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, ITPRLP, NOS2; 301. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, ODC1, IL6, ITPRLP, NOS2; 302. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, IL6, ITPRLP; 303. LUCAT1,

[0586] 2580 CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, IL6, NOS2; 304. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, ITPRLP, NOS2; 305. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, IL6, ITPRLP, NOS2; 306. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, ODC1, IL6, ITPRLP, NOS2; 307. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, ODC1, IL6, ITPRLP, NOS2; 308. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP;

[0587] 2585 309. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, IL6, NOS2; 310. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, ITPRLP, NOS2; 311. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, IL6, NOS2; 312. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, ITPRLP, NOS2; 313. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, ITPRLP, NOS2; 314. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE,

[0588] 2590 ODC1, IL6, ITPRLP, NOS2; 315. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3, ODC1, IL6,

[0589] 68

[0590] 4935-6038-7201 , v. 2 ITPRIP, NOS2; 316. LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1, IL6, ITPRIP, NOS2; 317. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 318. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 319. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 320. LUCAT1, CXCR1, CCL4, MMP1, CSF3,

[0591] 2595 S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 321. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 322. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 323. LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 324. LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 325. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 326. LUCAT1, CXCR1, CCL4,

[0592] 2600 MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 327. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 328. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 329. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 330. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 331. LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 332. LUCAT1,

[0593] 2605 CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 333. LUCAT1, CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 334. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 335. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 336. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 337. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2;

[0594] 2610 338. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 339. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 340. LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 341. LUCAT1, CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 342. LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 343. LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6,

[0595] 2615 ITPRIP, N0S2; 344. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 345. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 346. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 347. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 348. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 349. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3,

[0596] 2620 0DC1, IL6, ITPRIP, N0S2; 350. LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 351. LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 352.

[0597] 69

[0598] 4935-6038-7201 , v. 2 LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, NOS2; 353. LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 354. LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 355. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12,

[0599] 2625 SELE, HCAR3, 0DC1, IL6, ITPRIP; 356. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 357. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 358. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 359. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 360. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 361. CXCR1, CCL4, MMP1, MMP2, CSF3,

[0600] 2630 SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 362. CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 363. CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 364. CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2;

[0601] In embodiments, the measured genes can include the following genes:

[0602] 2635 1. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6; 2. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, ITPRIP; 3. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, NOS2; 4. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP; 5. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, NOS2; 6. DUOXA2,

[0603] 2640 LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ITPRIP, NOS2; 7. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, IL6, ITPRIP; 8. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, IL6, NOS2; 9. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, ITPRIP, NOS2; 10. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, IL6, ITPRIP, NOS2; 11. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1,

[0604] 2645 MMP2, CSF3, S100A12, HCAR3, ODC1, IL6, ITPRIP; 12. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, IL6, NOS2; 13. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, ITPRIP, NOS2; 14. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, IL6, ITPRIP, NOS2; 15. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, ODC1, IL6, ITPRIP, NOS2; 16. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE,

[0605] 2650 HCAR3, ODC1, IL6, ITPRIP; 17. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, IL6, NOS2; 18. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, ITPRIP, NOS2; 19. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, IL6, ITPRIP,

[0606] 70

[0607] 4935-6038-7201 , v. 2 NOS2; 20. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, 0DC1, IL6, ITPRLP, NOS2; 21. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 22. DU0XA2,

[0608] 2655 LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 23. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 24. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 25. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 26. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 27. DU0XA2,

[0609] 2660 LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 28. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 29. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 30. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 31. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 32. DU0XA2, LUCAT1, CXCR1, CCL4,

[0610] 2665 MMP1, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 33. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 34. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 35. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 36. DU0XA2, LUCAT1, CXCR1, CCL4, MMP1, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 37. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE,

[0611] 2670 HCAR3, 0DC1, IL6, ITPRLP; 38. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 39. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 40. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 41. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 42. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 43.

[0612] 2675 DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 44. DU0XA2, LUCAT1, CXCR1, CCL4, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 45. DU0XA2, LUCAT1, CXCR1, CCL4, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 46. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP; 47. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 48. DU0XA2,

[0613] 2680 LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRLP, N0S2; 49. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, N0S2; 50. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRLP, N0S2; 51. DU0XA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 52. DU0XA2,

[0614] 71

[0615] 4935-6038-7201 , v. 2 LUCAT1, CXCR1, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, NOS2; 53. DU0XA2, LUCAT1,

[0616] 2685 CXCR1, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 54. DU0XA2, LUCAT1, CXCR1, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 55. DU0XA2, LUCAT1, CXCR1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 56. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 57. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 58. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3,

[0617] 2690 S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 59. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 60. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 61. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 62. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 63. DU0XA2, LUCAT1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP,

[0618] 2695 N0S2; 64. DU0XA2, LUCAT1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 65. DU0XA2, LUCAT1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 66. DU0XA2, LUCAT1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 67.

[0619] DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 68. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 69. DU0XA2, CXCR1,

[0620] 2700 CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 70. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 71. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 72. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 73. DU0XA2, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 74. DU0XA2, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE,

[0621] 2705 HCAR3, 0DC1, IL6, ITPRIP, N0S2; 75. DU0XA2, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 76. DU0XA2, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 77. DU0XA2, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 78. DU0XA2, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 79. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP; 80.

[0622] 2710 LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, N0S2; 81. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, ITPRIP, N0S2; 82. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRIP, N0S2; 83. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, 0DC1, IL6, ITPRIP, N0S2; 84. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 85. LUCAT1, CXCR1, CCL4, MMP1, MMP2,

[0623] 72

[0624] 4935-6038-7201 , v. 2 2715 CSF3, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2; 86. LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 87. LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 88. LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 89. LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRIP, N0S2; 90. LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP,

[0625] 2720 N0S2; 91. CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, 0DC1, IL6, ITPRLP, N0S2

[0626] In embodiments, the measured genes can include the following genes:

[0627] 1. LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 2. DUOXA2, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 3.

[0628] 2725 DUOXA2, LUCAT1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 4. DUOXA2, LUCAT1, CXCR1, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 5. DUOXA2, LUCAT1, CXCR1, CCL4, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 6. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 7. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 8.

[0629] 2730 DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, SELE, HCAR3, ODC1, IL6, ITPRLP, NOS2; 9. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, HCAR3, ODC1, IL6, ITPRLP, NOS2; 10. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, ODC1, IL6, ITPRLP, NOS2; 11. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, IL6, ITPRLP, NOS2; 12. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, ITPRLP, NOS2;

[0630] 2735 13. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, NOS2;

[0631] 14. DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, MMP2, CSF3, S100A12, SELE, HCAR3, ODC1, IL6, ITPRLP.

[0632] Embodiments of the present disclosure include methods for treating a subject with an inflammatory bowel disease, the methods including obtaining a biological sample from the subject with inflammatory bowel

[0633] 2740 disease; and measuring gene expression levels of, for example, 6 to 9 genes. In embodiments, the measured genes can include two, three, four, five, or six of the following genes:; 1. NOS2, DU0XA2, MMP2, IGHG1, PRPS1, CSF3; 2. NOS2, DU0XA2, MMP2, IGHG1, PRPS1, CXCR1; 3. NOS2, DU0XA2, MMP2, IGHG1, PRPSL AVPIl; 4. NOS2, DU0XA2, MMP2, IGHG1, PRPS1, HCAR3; 5. NOS2, DU0XA2, MMP2, IGHG1, PRPS1, CALR; 6. NOS2, DU0XA2, MMP2, IGHG1, PRPS1, LUCAT1; 7. NOS2, DU0XA2, MMP2, IGHG1,

[0634] 2745 PRPS1, CCL4; 8. NOS2, DU0XA2, MMP2, IGHG1, PRPS1, CXCL8; 9. NOS2, DU0XA2, MMP2, IGHG1,

[0635] 73

[0636] 4935-6038-7201 , v. 2 PRPS1, S100A12; 10. N0S2, DU0XA2, MMP2, IGHG1, CSF3, CXCR1; 11. N0S2, DU0XA2, MMP2, IGHG1, CSF3, AVPI1; 12. N0S2, DU0XA2, MMP2, IGHG1, CSF3, HCAR3; 13. N0S2, DU0XA2, MMP2, IGHG1, CSF3, CALR; 14. N0S2, DU0XA2, MMP2, IGHG1, CSF3, LUCAT1; 15. N0S2, DU0XA2, MMP2, IGHG1, CSF3, CCL4; 16. N0S2, DU0XA2, MMP2, IGHG1, CSF3, CXCL8; 17. N0S2, DU0XA2, MMP2, IGHG1,

[0637] 2750 CSF3, S100A12; 18. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, AVPI1; 19. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, HCAR3; 20. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, CALR; 21. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, LUCAT1; 22. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, CCL4; 23. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, CXCL8; 24. N0S2, DU0XA2, MMP2, IGHG1, CXCR1, S100A12; 25. N0S2, DU0XA2, MMP2, IGHG1, AVPI1, HCAR3; 26. N0S2, DU0XA2, MMP2, IGHG1, AVPI1, CALR; 27. N0S2, DU0XA2,

[0638] 2755 MMP2, IGHG1, AVPI1, LUCAT1; 28. N0S2, DU0XA2, MMP2, IGHG1, AVPI1, CCL4; 29. N0S2, DU0XA2, MMP2, IGHG AVPIl, CXCL8; 30. N0S2, DU0XA2, MMP2, IGHG1, AVPI1, S100A12; 31. N0S2, DU0XA2, MMP2, IGHG1, HCAR3, CALR; 32. N0S2, DU0XA2, MMP2, IGHG1, HCAR3, LUCAT1; 33. N0S2, DU0XA2, MMP2, IGHG1, HCAR3, CCL4; 34. N0S2, DU0XA2, MMP2, IGHG1, HCAR3, CXCL8; 35. N0S2, DU0XA2, MMP2, IGHG1, HCAR3, S100A12; 36. N0S2, DU0XA2, MMP2, IGHG1, CALR, LUCAT1; 37.

[0639] 2760 N0S2, DU0XA2, MMP2, IGHG1, CALR, CCL4; 38. N0S2, DU0XA2, MMP2, IGHG1, CALR, CXCL8; 39.

[0640] N0S2, DU0XA2, MMP2, IGHG1, CALR, S100A12; 40. N0S2, DU0XA2, MMP2, IGHG1, LUCAT1, CCL4; 41. N0S2, DU0XA2, MMP2, IGHG1, LUCAT1, CXCL8; 42. N0S2, DU0XA2, MMP2, IGHG1, LUCAT1, S100A12; 43. N0S2, DU0XA2, MMP2, IGHG1, CCL4, CXCL8; 44. N0S2, DU0XA2, MMP2, IGHG1, CCL4, S100A12; 45. N0S2, DU0XA2, MMP2, IGHG1, CXCL8, S100A12; 46. N0S2, DU0XA2, MMP2, PRPS1,

[0641] 2765 CSF3, CXCR1; 47. N0S2, DU0XA2, MMP2, PRPS1, CSF3, AVPI1; 48. N0S2, DU0XA2, MMP2, PRPS1, CSF3, HCAR3; 49. N0S2, DU0XA2, MMP2, PRPS1, CSF3, CALR; 50. N0S2, DU0XA2, MMP2, PRPS1, CSF3, LUCAT1; 51. N0S2, DU0XA2, MMP2, PRPS1, CSF3, CCL4; 52. N0S2, DU0XA2, MMP2, PRPS1, CSF3, CXCL8; 53. N0S2, DU0XA2, MMP2, PRPS1, CSF3, S100A12; 54. N0S2, DU0XA2, MMP2, PRPS1, CXCR AVPIl; 55. N0S2, DU0XA2, MMP2, PRPS1, CXCR1, HCAR3; 56. N0S2, DU0XA2, MMP2, PRPS1,

[0642] 2770 CXCR1, CALR; 57. N0S2, DU0XA2, MMP2, PRPS1, CXCR1, LUCAT1; 58. N0S2, DU0XA2, MMP2, PRPS1, CXCR1, CCL4; 59. N0S2, DU0XA2, MMP2, PRPS1, CXCR1, CXCL8; 60. N0S2, DU0XA2, MMP2, PRPS1, CXCR1, S100A12; 61. N0S2, DU0XA2, MMP2, PRPS1, AVPI1, HCAR3; 62. N0S2, DU0XA2, MMP2, PRPS AVPIl, CALR; 63. N0S2, DU0XA2, MMP2, PRPS1, AVPI1, LUCAT1; 64. N0S2, DU0XA2, MMP2, PRPS AVPIl, CCL4; 65. N0S2, DU0XA2, MMP2, PRPS1, AVPI1, CXCL8; 66. N0S2, DU0XA2, MMP2,

[0643] 2775 PRPS AVPIl, S100A12; 67. N0S2, DU0XA2, MMP2, PRPS1, HCAR3, CALR; 68. N0S2, DU0XA2, MMP2, PRPS1, HCAR3, LUCAT1; 69. N0S2, DU0XA2, MMP2, PRPS1, HCAR3, CCL4; 70. N0S2, DU0XA2, MMP2,

[0644] 74

[0645] 4935-6038-7201 , v. 2 PRPS1, HCAR3, CXCL8; 71. N0S2, DU0XA2, MMP2, PRPS1, HCAR3, S100A12; 72. NOS2, DU0XA2, MMP2, PRPS1, CALR, LUCAT1; 73. N0S2, DU0XA2, MMP2, PRPS1, CALR, CCL4; 74. N0S2, DU0XA2, MMP2, PRPS1, CALR, CXCL8; 75. N0S2, DU0XA2, MMP2, PRPS1, CALR, S100A12; 76. N0S2, DU0XA2,

[0646] 2780 MMP2, PRPS1, LUCAT1, CCL4; 77. N0S2, DU0XA2, MMP2, PRPS1, LUCAT1, CXCL8; 78. N0S2, DU0XA2, MMP2, PRPS1, LUCAT1, S100A12; 79. N0S2, DU0XA2, MMP2, PRPS1, CCL4, CXCL8; 80. N0S2, DU0XA2, MMP2, PRPS1, CCL4, S100A12; 81. N0S2, DU0XA2, MMP2, PRPS1, CXCL8, S100A12; 82. N0S2, DU0XA2, MMP2, CSF3, CXCR AVPIl; 83. N0S2, DU0XA2, MMP2, CSF3, CXCR1, HCAR3; 84. N0S2, DU0XA2, MMP2, CSF3, CXCR1, CALR; 85. N0S2, DU0XA2, MMP2, CSF3, CXCR1, LUCAT1; 86.

[0647] 2785 N0S2, DU0XA2, MMP2, CSF3, CXCR1, CCL4; 87. N0S2, DU0XA2, MMP2, CSF3, CXCR1, CXCL8; 88. N0S2, DU0XA2, MMP2, CSF3, CXCR1, S100A12; 89. N0S2, DU0XA2, MMP2, CSF3, AVPI1, HCAR3; 90. N0S2, DU0XA2, MMP2, CSF3, AVPI1, CALR; 91. N0S2, DU0XA2, MMP2, CSF3, AVPI1, LUCAT1; 92. N0S2, DU0XA2, MMP2, CSF3, AVPI1, CCL4; 93. N0S2, DU0XA2, MMP2, CSF3, AVPI1, CXCL8; 94. N0S2, DU0XA2, MMP2, CSF3, AVPI1, S100A12; 95. N0S2, DU0XA2, MMP2, CSF3, HCAR3, CALR; 96.

[0648] 2790 N0S2, DU0XA2, MMP2, CSF3, HCAR3, LUCAT1; 97. N0S2, DU0XA2, MMP2, CSF3, HCAR3, CCL4; 98. N0S2, DU0XA2, MMP2, CSF3, HCAR3, CXCL8; 99. N0S2, DU0XA2, MMP2, CSF3, HCAR3, S100A12; 100. N0S2, DU0XA2, MMP2, CSF3, CALR, LUCAT1; 101. N0S2, DU0XA2, MMP2, CSF3, CALR, CCL4; 102. N0S2, DU0XA2, MMP2, CSF3, CALR, CXCL8; 103. N0S2, DU0XA2, MMP2, CSF3, CALR, S100A12; 104. N0S2, DU0XA2, MMP2, CSF3, LUCAT1, CCL4; 105. N0S2, DU0XA2, MMP2, CSF3, LUCAT1, CXCL8;

[0649] 2795 106. N0S2, DU0XA2, MMP2, CSF3, LUCAT1, S100A12; 107. N0S2, DU0XA2, MMP2, CSF3, CCL4, CXCL8; 108. N0S2, DU0XA2, MMP2, CSF3, CCL4, S100A12; 109. N0S2, DU0XA2, MMP2, CSF3, CXCL8, S100A12; 110. N0S2, DU0XA2, MMP2, CXCR1, AVPI1, HCAR3; 111. N0S2, DU0XA2, MMP2, CXCR1, AVPI1, CALR; 112. N0S2, DU0XA2, MMP2, CXCR1, AVPI1, LUCAT1; 113. N0S2, DU0XA2, MMP2, CXCR AVPIl, CCL4; 114. N0S2, DU0XA2, MMP2, CXCR1, AVPI1, CXCL8; 115. N0S2, DU0XA2, MMP2,

[0650] 2800 CXCR AVPIl, S100A12; 116. N0S2, DU0XA2, MMP2, CXCR1, HCAR3, CALR; 117. N0S2, DU0XA2, MMP2, CXCR1, HCAR3, LUCAT1; 118. N0S2, DU0XA2, MMP2, CXCR1, HCAR3, CCL4; 119. N0S2, DU0XA2, MMP2, CXCR1, HCAR3, CXCL8; 120. N0S2, DU0XA2, MMP2, CXCR1, HCAR3, S100A12; 121. N0S2, DU0XA2, MMP2, CXCR1, CALR, LUCAT1; 122. N0S2, DU0XA2, MMP2, CXCR1, CALR, CCL4; 123. N0S2, DU0XA2, MMP2, CXCR1, CALR, CXCL8; 124. N0S2, DU0XA2, MMP2, CXCR1, CALR, S100A12;

[0651] 2805 125. N0S2, DU0XA2, MMP2, CXCR1, LUCAT1, CCL4; 126. N0S2, DU0XA2, MMP2, CXCR1, LUCAT1, CXCL8; 127. N0S2, DU0XA2, MMP2, CXCR1, LUCAT1, S100A12; 128. N0S2, DU0XA2, MMP2, CXCR1, CCL4, CXCL8; 129. N0S2, DU0XA2, MMP2, CXCR1, CCL4, S100A12; 130. N0S2, DU0XA2, MMP2,

[0652] 75

[0653] 4935-6038-7201 , v. 2 CXCR1, CXCL8, S100A12; 131. N0S2, DU0XA2, MMP2, AVPI1, HCAR3, CALR; 132. N0S2, DU0XA2, MMP2, AVPI1, HCAR3, LUCAT1; 133. N0S2, DU0XA2, MMP2, AVPI1, HCAR3, CCL4; 134. N0S2,

[0654] 2810 DU0XA2, MMP2, AVPI1, HCAR3, CXCL8; 135. N0S2, DU0XA2, MMP2, AVPI1, HCAR3, S100A12; 136. N0S2, DU0XA2, MMP2, AVPI1, CALR, LUCAT1; 137. N0S2, DU0XA2, MMP2, AVPI1, CALR, CCL4; 138. N0S2, DU0XA2, MMP2, AVPI1, CALR, CXCL8; 139. N0S2, DU0XA2, MMP2, AVPI1, CALR, S100A12; 140. N0S2, DU0XA2, MMP2, AVPI1, LUCAT1, CCL4; 141. N0S2, DU0XA2, MMP2, AVPI1, LUCAT1, CXCL8; 142. N0S2, DU0XA2, MMP2, AVPI1, LUCAT1, S100A12; 143. N0S2, DU0XA2, MMP2, AVPI1, CCL4,

[0655] 2815 CXCL8; 144. N0S2, DU0XA2, MMP2, AVPI1, CCL4, S100A12; 145. N0S2, DU0XA2, MMP2, AVPI1, CXCL8, S100A12; 146. N0S2, DU0XA2, MMP2, HCAR3, CALR, LUCAT1; 147. N0S2, DU0XA2, MMP2, HCAR3, CALR, CCL4; 148. N0S2, DU0XA2, MMP2, HCAR3, CALR, CXCL8; 149. N0S2, DU0XA2, MMP2, HCAR3, CALR, S100A12; 150. N0S2, DU0XA2, MMP2, HCAR3, LUCAT1, CCL4; 151. N0S2, DU0XA2, MMP2, HCAR3, LUCAT1, CXCL8; 152. N0S2, DU0XA2, MMP2, HCAR3, LUCAT1, S100A12; 153. N0S2,

[0656] 2820 DU0XA2, MMP2, HCAR3, CCL4, CXCL8; 154. N0S2, DU0XA2, MMP2, HCAR3, CCL4, S100A12; 155. N0S2, DU0XA2, MMP2, HCAR3, CXCL8, S100A12; 156. N0S2, DU0XA2, MMP2, CALR, LUCAT1, CCL4; 157. N0S2, DU0XA2, MMP2, CALR, LUCAT1, CXCL8; 158. N0S2, DU0XA2, MMP2, CALR, LUCAT1, S100A12; 159. N0S2, DU0XA2, MMP2, CALR, CCL4, CXCL8; 160. N0S2, DU0XA2, MMP2, CALR, CCL4, S100A12; 161. N0S2, DU0XA2, MMP2, CALR, CXCL8, S100A12; 162. N0S2, DU0XA2, MMP2, LUCAT1,

[0657] 2825 CCL4, CXCL8; 163. N0S2, DU0XA2, MMP2, LUCAT1, CCL4, S100A12; 164. N0S2, DU0XA2, MMP2, LUCAT1, CXCL8, S100A12; 165. N0S2, DU0XA2, MMP2, CCL4, CXCL8, S100A12; 166. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, CXCR1; 167. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, AVPI1; 168. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, HCAR3; 169. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, CALR; 170. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, LUCAT1; 171. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, CCL4; 172. N0S2, DU0XA2,

[0658] 2830 IGHG1, PRPS1, CSF3, CXCL8; 173. N0S2, DU0XA2, IGHG1, PRPS1, CSF3, S100A12; 174. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, AVPI1; 175. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, HCAR3; 176. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, CALR; 177. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, LUCAT1; 178. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, CCL4; 179. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, CXCL8; 180. N0S2, DU0XA2, IGHG1, PRPS1, CXCR1, S100A12; 181. N0S2, DU0XA2, IGHG1, PRPS1,

[0659] 2835 AVPI1, HCAR3; 182. N0S2, DU0XA2, IGHG1, PRPS1, AVPI1, CALR; 183. N0S2, DU0XA2, IGHG1, PRPS1, AVPI1, LUCAT1; 184. N0S2, DU0XA2, IGHG1, PRPS1, AVPI1, CCL4; 185. N0S2, DU0XA2, IGHG1, PRPSL AVPIl, CXCL8; 186. N0S2, DU0XA2, IGHG1, PRPS1, AVPI1, S100A12; 187. N0S2, DU0XA2, IGHG1, PRPS1, HCAR3, CALR; 188. N0S2, DU0XA2, IGHG1, PRPS1, HCAR3, LUCAT1; 189. N0S2,

[0660] 76

[0661] 4935-6038-7201 , v. 2 DU0XA2, IGHG1, PRPS1, HCAR3, CCL4; 190. N0S2, DU0XA2, IGHG1, PRPS1, HCAR3, CXCL8; 191.

[0662] 2840 N0S2, DU0XA2, IGHG1, PRPS1, HCAR3, S100A12; 192. N0S2, DU0XA2, IGHG1, PRPS1, CALR, LUCAT1; 193. N0S2, DU0XA2, IGHG1, PRPS1, CALR, CCL4; 194. N0S2, DU0XA2, IGHG1, PRPS1, CALR, CXCL8; 195. N0S2, DU0XA2, IGHG1, PRPS1, CALR, S100A12; 196. N0S2, DU0XA2, IGHG1, PRPS1, LUCAT1, CCL4; 197. N0S2, DU0XA2, IGHG1, PRPS1, LUCAT1, CXCL8; 198. N0S2, DU0XA2, IGHG1, PRPS1, LUCAT1, S100A12; 199. N0S2, DU0XA2, IGHG1, PRPS1, CCL4, CXCL8; 200. N0S2, DU0XA2, IGHG1,

[0663] 2845 PRPS1, CCL4, S100A12; 201. N0S2, DU0XA2, IGHG1, PRPS1, CXCL8, S100A12; 202. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, AVPI1; 203. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, HCAR3; 204. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, CALR; 205. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, LUCAT1; 206. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, CCL4; 207. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, CXCL8; 208. N0S2, DU0XA2, IGHG1, CSF3, CXCR1, S100A12; 209. N0S2, DU0XA2, IGHG1, CSF3, AVPI1, HCAR3; 210.

[0664] 2850 N0S2, DU0XA2, IGHG1, CSF3, AVPI1, CALR; 211. N0S2, DU0XA2, IGHG1, CSF3, AVPI1, LUCAT1; 212. N0S2, DU0XA2, IGHG1, CSF3, AVPI1, CCL4; 213. N0S2, DU0XA2, IGHG1, CSF3, AVPI1, CXCL8; 214. N0S2, DU0XA2, IGHG1, CSF3, AVPI1, S100A12; 215. N0S2, DU0XA2, IGHG1, CSF3, HCAR3, CALR; 216. N0S2, DU0XA2, IGHG1, CSF3, HCAR3, LUCAT1; 217. N0S2, DU0XA2, IGHG1, CSF3, HCAR3, CCL4; 218. N0S2, DU0XA2, IGHG1, CSF3, HCAR3, CXCL8; 219. N0S2, DU0XA2, IGHG1, CSF3, HCAR3,

[0665] 2855 S100A12; 220. N0S2, DU0XA2, IGHG1, CSF3, CALR, LUCAT1; 221. N0S2, DU0XA2, IGHG1, CSF3, CALR, CCL4; 222. N0S2, DU0XA2, IGHG1, CSF3, CALR, CXCL8; 223. N0S2, DU0XA2, IGHG1, CSF3, CALR, S100A12; 224. N0S2, DU0XA2, IGHG1, CSF3, LUCAT1, CCL4; 225. N0S2, DU0XA2, IGHG1, CSF3, LUCAT1, CXCL8; 226. N0S2, DU0XA2, IGHG1, CSF3, LUCAT1, S100A12; 227. N0S2, DU0XA2, IGHG1, CSF3, CCL4, CXCL8; 228. N0S2, DU0XA2, IGHG1, CSF3, CCL4, S100A12; 229. N0S2, DU0XA2, IGHG1,

[0666] 2860 CSF3, CXCL8, S100A12; 230. N0S2, DU0XA2, IGHG1, CXCR1, AVPI1, HCAR3; 231. N0S2, DU0XA2, IGHG1, CXCRL AVPIl, CALR; 232. N0S2, DU0XA2, IGHG1, CXCR1, AVPI1, LUCAT1; 233. N0S2, DU0XA2, IGHG1, CXCR1, AVPI1, CCL4; 234. N0S2, DU0XA2, IGHG1, CXCR1, AVPI1, CXCL8; 235. N0S2, DU0XA2, IGHG1, CXCRL AVPIl, S100A12; 236. N0S2, DU0XA2, IGHG1, CXCR1, HCAR3, CALR; 237. N0S2, DU0XA2, IGHG1, CXCR1, HCAR3, LUCAT1; 238. N0S2, DU0XA2, IGHG1, CXCR1, HCAR3,

[0667] 2865 CCL4; 239. N0S2, DU0XA2, IGHG1, CXCR1, HCAR3, CXCL8; 240. N0S2, DU0XA2, IGHG1, CXCR1, HCAR3, S100A12; 241. N0S2, DU0XA2, IGHG1, CXCR1, CALR, LUCAT1; 242. N0S2, DU0XA2, IGHG1, CXCR1, CALR, CCL4; 243. N0S2, DU0XA2, IGHG1, CXCR1, CALR, CXCL8; 244. N0S2, DU0XA2, IGHG1, CXCR1, CALR, S100A12; 245. N0S2, DU0XA2, IGHG1, CXCR1, LUCAT1, CCL4; 246. N0S2, DU0XA2, IGHG1, CXCR1, LUCAT1, CXCL8; 247. N0S2, DU0XA2, IGHG1, CXCR1, LUCAT1, S100A12; 248. N0S2,

[0668] 77

[0669] 4935-6038-7201 , v. 2 2870 DU0XA2, IGHG1, CXCR1, CCL4, CXCL8; 249. N0S2, DU0XA2, IGHG1, CXCR1, CCL4, S100A12; 250. N0S2, DU0XA2, IGHG1, CXCR1, CXCL8, S100A12; 251. N0S2, DU0XA2, IGHG1, AVPI1, HCAR3, CALR; 252. N0S2, DU0XA2, IGHG1, AVPI1, HCAR3, LUCAT1; 253. N0S2, DU0XA2, IGHG1, AVPI1, HCAR3, CCL4; 254. N0S2, DU0XA2, IGHG1, AVPI1, HCAR3, CXCL8; 255. N0S2, DU0XA2, IGHG1, AVPI1, HCAR3, S100A12; 256. N0S2, DU0XA2, IGHG1, AVPI1, CALR, LUCAT1; 257. N0S2, DU0XA2, IGHG1,

[0670] 2875 AVPI1, CALR, CCL4; 258. N0S2, DU0XA2, IGHG1, AVPI1, CALR, CXCL8; 259. N0S2, DU0XA2, IGHG1, AVPI1, CALR, S100A12; 260. N0S2, DU0XA2, IGHG1, AVPI1, LUCAT1, CCL4; 261. N0S2, DU0XA2, IGHGL AVPIl, LUCAT1, CXCL8; 262. N0S2, DU0XA2, IGHG1, AVPI1, LUCAT1, S100A12; 263. N0S2, DU0XA2, IGHG1, AVPI1, CCL4, CXCL8; 264. N0S2, DU0XA2, IGHG1, AVPI1, CCL4, S100A12; 265. N0S2, DU0XA2, IGHG1, AVPI1, CXCL8, S100A12; 266. N0S2, DU0XA2, IGHG1, HCAR3, CALR, LUCAT1;

[0671] 2880 267. N0S2, DU0XA2, IGHG1, HCAR3, CALR, CCL4; 268. N0S2, DU0XA2, IGHG1, HCAR3, CALR, CXCL8; 269. N0S2, DU0XA2, IGHG1, HCAR3, CALR, S100A12; 270. N0S2, DU0XA2, IGHG1, HCAR3, LUCAT1, CCL4; 271. N0S2, DU0XA2, IGHG1, HCAR3, LUCAT1, CXCL8; 272. N0S2, DU0XA2, IGHG1, HCAR3, LUCAT1, S100A12; 273. N0S2, DU0XA2, IGHG1, HCAR3, CCL4, CXCL8; 274. N0S2, DU0XA2, IGHG1, HCAR3, CCL4, S100A12; 275. N0S2, DU0XA2, IGHG1, HCAR3, CXCL8, S100A12; 276. N0S2, DU0XA2,

[0672] 2885 IGHG1, CALR, LUCAT1, CCL4; 277. N0S2, DU0XA2, IGHG1, CALR, LUCAT1, CXCL8; 278. N0S2, DU0XA2, IGHG1, CALR, LUCAT1, S100A12; 279. N0S2, DU0XA2, IGHG1, CALR, CCL4, CXCL8; 280. N0S2, DU0XA2, IGHG1, CALR, CCL4, S100A12; 281. N0S2, DU0XA2, IGHG1, CALR, CXCL8, S100A12; 282. N0S2, DU0XA2, IGHG1, LUCAT1, CCL4, CXCL8; 283. N0S2, DU0XA2, IGHG1, LUCAT1, CCL4, S100A12; 284. N0S2, DU0XA2, IGHG1, LUCAT1, CXCL8, S100A12; 285. N0S2, DU0XA2, IGHG1, CCL4,

[0673] 2890 CXCL8, S100A12; 286. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, AVPI1; 287. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, HCAR3; 288. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, CALR; 289. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, LUCAT1; 290. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, CCL4; 291. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, CXCL8; 292. N0S2, DU0XA2, PRPS1, CSF3, CXCR1, S100A12; 293. N0S2, DU0XA2, PRPS1, CSF3, AVPI1, HCAR3; 294. N0S2, DU0XA2, PRPS1, CSF3, AVPI1, CALR; 295. N0S2, DU0XA2, PRPS1,

[0674] 2895 CSF3, AVPI1, LUCAT1; 296. N0S2, DU0XA2, PRPS1, CSF3, AVPI1, CCL4; 297. N0S2, DU0XA2, PRPS1, CSF3, AVPI1, CXCL8; 298. N0S2, DU0XA2, PRPS1, CSF3, AVPI1, S100A12; 299. N0S2, DU0XA2, PRPS1, CSF3, HCAR3, CALR; 300. N0S2, DU0XA2, PRPS1, CSF3, HCAR3, LUCAT1; 301. N0S2, DU0XA2, PRPS1, CSF3, HCAR3, CCL4; 302. N0S2, DU0XA2, PRPS1, CSF3, HCAR3, CXCL8; 303. N0S2, DU0XA2, PRPS1, CSF3, HCAR3, S100A12; 304. N0S2, DU0XA2, PRPS1, CSF3, CALR, LUCAT1; 305. N0S2, DU0XA2,

[0675] 2900 PRPS1, CSF3, CALR, CCL4; 306. N0S2, DU0XA2, PRPS1, CSF3, CALR, CXCL8; 307. N0S2, DU0XA2,

[0676] 78

[0677] 4935-6038-7201 , v. 2 PRPS1, CSF3, CALR, S100A12; 308. N0S2, DU0XA2, PRPS1, CSF3, LUCAT1, CCL4; 309. N0S2, DU0XA2, PRPS1, CSF3, LUCAT1, CXCL8; 310. N0S2, DU0XA2, PRPS1, CSF3, LUCAT1, S100A12; 311. N0S2, DU0XA2, PRPS1, CSF3, CCL4, CXCL8; 312. N0S2, DU0XA2, PRPS1, CSF3, CCL4, S100A12; 313. N0S2, DU0XA2, PRPS1, CSF3, CXCL8, S100A12; 314. N0S2, DU0XA2, PRPS1, CXCR1, AVPI1, HCAR3; 315.

[0678] 2905 N0S2, DU0XA2, PRPS1, CXCR1, AVPI1, CALR; 316. N0S2, DU0XA2, PRPS1, CXCR1, AVPI1, LUCAT1; 317. N0S2, DU0XA2, PRPS1, CXCR1, AVPI1, CCL4; 318. N0S2, DU0XA2, PRPS1, CXCR1, AVPI1, CXCL8; 319. N0S2, DU0XA2, PRPS1, CXCR1, AVPI1, S100A12; 320. N0S2, DU0XA2, PRPS1, CXCR1, HCAR3, CALR; 321. N0S2, DU0XA2, PRPS1, CXCR1, HCAR3, LUCAT1; 322. N0S2, DU0XA2, PRPS1, CXCR1, HCAR3, CCL4; 323. N0S2, DU0XA2, PRPS1, CXCR1, HCAR3, CXCL8; 324. N0S2, DU0XA2, PRPS1,

[0679] 2910 CXCR1, HCAR3, S100A12; 325. N0S2, DU0XA2, PRPS1, CXCR1, CALR, LUCAT1; 326. N0S2, DU0XA2, PRPS1, CXCR1, CALR, CCL4; 327. N0S2, DU0XA2, PRPS1, CXCR1, CALR, CXCL8; 328. N0S2, DU0XA2, PRPS1, CXCR1, CALR, S100A12; 329. N0S2, DU0XA2, PRPS1, CXCR1, LUCAT1, CCL4; 330. N0S2, DU0XA2, PRPS1, CXCR1, LUCAT1, CXCL8; 331. N0S2, DU0XA2, PRPS1, CXCR1, LUCAT1, S100A12; 332. N0S2, DU0XA2, PRPS1, CXCR1, CCL4, CXCL8; 333. N0S2, DU0XA2, PRPS1, CXCR1, CCL4,

[0680] 2915 S100A12; 334. N0S2, DU0XA2, PRPS1, CXCR1, CXCL8, S100A12; 335. N0S2, DU0XA2, PRPS1, AVPI1, HCAR3, CALR; 336. N0S2, DU0XA2, PRPS1, AVPI1, HCAR3, LUCAT1; 337. N0S2, DU0XA2, PRPS1, AVPI1, HCAR3, CCL4; 338. N0S2, DU0XA2, PRPS1, AVPI1, HCAR3, CXCL8; 339. N0S2, DU0XA2, PRPS1, AVPI1, HCAR3, S100A12; 340. N0S2, DU0XA2, PRPS1, AVPI1, CALR, LUCAT1; 341. N0S2, DU0XA2, PRPS AVPIl, CALR, CCL4; 342. N0S2, DU0XA2, PRPS1, AVPI1, CALR, CXCL8; 343. N0S2, DU0XA2,

[0681] 2920 PRPS1, AVPI1, CALR, S100A12; 344. N0S2, DU0XA2, PRPS1, AVPI1, LUCAT1, CCL4; 345. N0S2, DU0XA2, PRPS1, AVPI1, LUCAT1, CXCL8; 346. N0S2, DU0XA2, PRPS1, AVPI1, LUCAT1, S100A12; 347. N0S2, DU0XA2, PRPS1, AVPI1, CCL4, CXCL8; 348. N0S2, DU0XA2, PRPS AVPIl, CCL4, S100A12; 349. N0S2, DU0XA2, PRPS1, AVPI1, CXCL8, S100A12; 350. N0S2, DU0XA2, PRPS1, HCAR3, CALR, LUCAT1; 351. N0S2, DU0XA2, PRPS1, HCAR3, CALR, CCL4; 352. N0S2, DU0XA2, PRPS1, HCAR3, CALR, CXCL8;

[0682] 2925 353. N0S2, DU0XA2, PRPS1, HCAR3, CALR, S100A12; 354. N0S2, DU0XA2, PRPS1, HCAR3, LUCAT1, CCL4; 355. N0S2, DU0XA2, PRPS1, HCAR3, LUCAT1, CXCL8; 356. N0S2, DU0XA2, PRPS1, HCAR3, LUCAT1, S100A12; 357. N0S2, DU0XA2, PRPS1, HCAR3, CCL4, CXCL8; 358. N0S2, DU0XA2, PRPS1, HCAR3, CCL4, S100A12; 359. N0S2, DU0XA2, PRPS1, HCAR3, CXCL8, S100A12; 360. N0S2, DU0XA2, PRPS1, CALR, LUCAT1, CCL4; 361. N0S2, DU0XA2, PRPS1, CALR, LUCAT1, CXCL8; 362. N0S2,

[0683] 2930 DU0XA2, PRPS1, CALR, LUCAT1, S100A12; 363. N0S2, DU0XA2, PRPS1, CALR, CCL4, CXCL8; 364. N0S2, DU0XA2, PRPS1, CALR, CCL4, S100A12; 365. N0S2, DU0XA2, PRPS1, CALR, CXCL8, S100A12;

[0684] 79

[0685] 4935-6038-7201 , v. 2 366. N0S2, DU0XA2, PRPS1, LUCAT1, CCL4, CXCL8; 367. N0S2, DU0XA2, PRPS1, LUCAT1, CCL4, S100A12; 368. N0S2, DU0XA2, PRPS1, LUCAT1, CXCL8, S100A12; 369. N0S2, DU0XA2, PRPS1, CCL4, CXCL8, S100A12; 370. N0S2, DU0XA2, CSF3, CXCR1, AVPI1, HCAR3; 371. N0S2, DU0XA2, CSF3,

[0686] 2935 CXCR1, AVPI1, CALR; 372. N0S2, DU0XA2, CSF3, CXCR1, AVPI1, LUCAT1; 373. N0S2, DU0XA2, CSF3, CXCR1, AVPI1, CCL4; 374. N0S2, DU0XA2, CSF3, CXCR1, AVPI1, CXCL8; 375. N0S2, DU0XA2, CSF3, CXCR1, AVPI1, S100A12; 376. N0S2, DU0XA2, CSF3, CXCR1, HCAR3, CALR; 377. N0S2, DU0XA2, CSF3, CXCR1, HCAR3, LUCAT1; 378. N0S2, DU0XA2, CSF3, CXCR1, HCAR3, CCL4; 379. N0S2, DU0XA2, CSF3, CXCR1, HCAR3, CXCL8; 380. N0S2, DU0XA2, CSF3, CXCR1, HCAR3, S100A12; 381. N0S2,

[0687] 2940 DU0XA2, CSF3, CXCR1, CALR, LUCAT1; 382. N0S2, DU0XA2, CSF3, CXCR1, CALR, CCL4; 383. N0S2, DU0XA2, CSF3, CXCR1, CALR, CXCL8; 384. N0S2, DU0XA2, CSF3, CXCR1, CALR, S100A12; 385. N0S2, DU0XA2, CSF3, CXCR1, LUCAT1, CCL4; 386. N0S2, DU0XA2, CSF3, CXCR1, LUCAT1, CXCL8; 387. N0S2, DU0XA2, CSF3, CXCR1, LUCAT1, S100A12; 388. N0S2, DU0XA2, CSF3, CXCR1, CCL4, CXCL8; 389. N0S2, DU0XA2, CSF3, CXCR1, CCL4, S100A12; 390. N0S2, DU0XA2, CSF3, CXCR1, CXCL8,

[0688] 2945 S100A12; 391. N0S2, DU0XA2, CSF3, AVPI1, HCAR3, CALR; 392. N0S2, DU0XA2, CSF3, AVPI1, HCAR3, LUCAT1; 393. N0S2, DU0XA2, CSF3, AVPI1, HCAR3, CCL4; 394. N0S2, DU0XA2, CSF3, AVPI1, HCAR3, CXCL8; 395. N0S2, DU0XA2, CSF3, AVPI1, HCAR3, S100A12; 396. N0S2, DU0XA2, CSF3, AVPI1, CALR, LUCAT1; 397. N0S2, DU0XA2, CSF3, AVPI1, CALR, CCL4; 398. N0S2, DU0XA2, CSF3, AVPI1, CALR, CXCL8; 399. N0S2, DU0XA2, CSF3, AVPI1, CALR, S100A12; 400. N0S2, DU0XA2, CSF3, AVPI1, LUCAT1,

[0689] 2950 CCL4; 401. N0S2, DU0XA2, CSF3, AVPI1, LUCAT1, CXCL8; 402. N0S2, DU0XA2, CSF3, AVPI1, LUCAT1, S100A12; 403. N0S2, DU0XA2, CSF3, AVPI1, CCL4, CXCL8; 404. N0S2, DU0XA2, CSF3, AVPI1, CCL4, S100A12; 405. N0S2, DU0XA2, CSF3, AVPI1, CXCL8, S100A12; 406. N0S2, DU0XA2, CSF3, HCAR3, CALR, LUCAT1; 407. N0S2, DU0XA2, CSF3, HCAR3, CALR, CCL4; 408. N0S2, DU0XA2, CSF3, HCAR3, CALR, CXCL8; 409. N0S2, DU0XA2, CSF3, HCAR3, CALR, S100A12; 410. N0S2, DU0XA2, CSF3, HCAR3,

[0690] 2955 LUCAT1, CCL4; 411. N0S2, DU0XA2, CSF3, HCAR3, LUCAT1, CXCL8; 412. N0S2, DU0XA2, CSF3, HCAR3, LUCAT1, S100A12; 413. N0S2, DU0XA2, CSF3, HCAR3, CCL4, CXCL8; 414. N0S2, DU0XA2, CSF3, HCAR3, CCL4, S100A12; 415. N0S2, DU0XA2, CSF3, HCAR3, CXCL8, S100A12; 416. N0S2, DU0XA2, CSF3, CALR, LUCAT1, CCL4; 417. N0S2, DU0XA2, CSF3, CALR, LUCAT1, CXCL8; 418. N0S2, DU0XA2, CSF3, CALR, LUCAT1, S100A12; 419. N0S2, DU0XA2, CSF3, CALR, CCL4, CXCL8; 420. N0S2,

[0691] 2960 DU0XA2, CSF3, CALR, CCL4, S100A12; 421. N0S2, DU0XA2, CSF3, CALR, CXCL8, S100A12; 422. N0S2, DU0XA2, CSF3, LUCAT1, CCL4, CXCL8; 423. N0S2, DU0XA2, CSF3, LUCAT1, CCL4, S100A12; 424. N0S2, DU0XA2, CSF3, LUCAT1, CXCL8, S100A12; 425. N0S2, DU0XA2, CSF3, CCL4, CXCL8, S100A12;

[0692] 80

[0693] 4935-6038-7201 , v. 2 426. N0S2, DU0XA2, CXCR1, AVPI1, HCAR3, CALR; 427. N0S2, DU0XA2, CXCR1, AVPI1, HCAR3, LUCAT1; 428. N0S2, DU0XA2, CXCR1, AVPI1, HCAR3, CCL4; 429. N0S2, DU0XA2, CXCR1, AVPI1,

[0694] 2965 HCAR3, CXCL8; 430. N0S2, DU0XA2, CXCR1, AVPI1, HCAR3, S100A12; 431. N0S2, DU0XA2, CXCR1, AVPI1, CALR, LUCAT1; 432. N0S2, DU0XA2, CXCR AVPIl, CALR, CCL4; 433. N0S2, DU0XA2, CXCR1, AVPI1, CALR, CXCL8; 434. N0S2, DU0XA2, CXCR1, AVPI1, CALR, S100A12; 435. N0S2, DU0XA2, CXCR AVPIl, LUCAT1, CCL4; 436. N0S2, DU0XA2, CXCR1, AVPI1, LUCAT1, CXCL8; 437. N0S2, DU0XA2, CXCR AVPIl, LUCAT1, S100A12; 438. N0S2, DU0XA2, CXCR AVPIl, CCL4, CXCL8; 439.

[0695] 2970 N0S2, DU0XA2, CXCR1, AVPI1, CCL4, S100A12; 440. N0S2, DU0XA2, CXCR AVPIl, CXCL8, S100A12; 441. N0S2, DU0XA2, CXCR1, HCAR3, CALR, LUCAT1; 442. N0S2, DU0XA2, CXCR1, HCAR3, CALR, CCL4; 443. N0S2, DU0XA2, CXCR1, HCAR3, CALR, CXCL8; 444. N0S2, DU0XA2, CXCR1, HCAR3, CALR, S100A12; 445. N0S2, DU0XA2, CXCR1, HCAR3, LUCAT1, CCL4; 446. N0S2, DU0XA2, CXCR1, HCAR3, LUCAT1, CXCL8; 447. N0S2, DU0XA2, CXCR1, HCAR3, LUCAT1, S100A12; 448. N0S2, DU0XA2, CXCR1,

[0696] 2975 HCAR3, CCL4, CXCL8; 449. N0S2, DU0XA2, CXCR1, HCAR3, CCL4, S100A12; 450. N0S2, DU0XA2, CXCR1, HCAR3, CXCL8, S100A12; 451. N0S2, DU0XA2, CXCR1, CALR, LUCAT1, CCL4; 452. N0S2, DU0XA2, CXCR1, CALR, LUCAT1, CXCL8; 453. N0S2, DU0XA2, CXCR1, CALR, LUCAT1, S100A12; 454. N0S2, DU0XA2, CXCR1, CALR, CCL4, CXCL8; 455. N0S2, DU0XA2, CXCR1, CALR, CCL4, S100A12; 456. N0S2, DU0XA2, CXCR1, CALR, CXCL8, S100A12; 457. N0S2, DU0XA2, CXCR1, LUCAT1, CCL4, CXCL8;

[0697] 2980 458. N0S2, DU0XA2, CXCR1, LUCAT1, CCL4, S100A12; 459. N0S2, DU0XA2, CXCR1, LUCAT1, CXCL8, S100A12; 460. N0S2, DU0XA2, CXCR1, CCL4, CXCL8, S100A12; 461. N0S2, DU0XA2, AVPI1, HCAR3, CALR, LUCAT1; 462. N0S2, DU0XA2, AVPI1, HCAR3, CALR, CCL4; 463. N0S2, DU0XA2, AVPI1, HCAR3, CALR, CXCL8; 464. N0S2, DU0XA2, AVPI1, HCAR3, CALR, S100A12; 465. N0S2, DU0XA2, AVPI1, HCAR3, LUCAT1, CCL4; 466. N0S2, DU0XA2, AVPI1, HCAR3, LUCAT1, CXCL8; 467. N0S2, DU0XA2,

[0698] 2985 AVPI1, HCAR3, LUCAT1, S100A12; 468. N0S2, DU0XA2, AVPI1, HCAR3, CCL4, CXCL8; 469. N0S2, DU0XA2, AVPI1, HCAR3, CCL4, S100A12; 470. N0S2, DU0XA2, AVPI1, HCAR3, CXCL8, S100A12; 471. N0S2, DUOXA2, AVPI1, CALR, LUCAT1, CCL4; 472. N0S2, DU0XA2, AVPI1, CALR, LUCAT1, CXCL8; 473. N0S2, DU0XA2, AVPI1, CALR, LUCAT1, S100A12; 474. N0S2, DU0XA2, AVPI1, CALR, CCL4, CXCL8; 475. N0S2, DU0XA2, AVPI1, CALR, CCL4, S100A12; 476. N0S2, DU0XA2, AVPI1, CALR, CXCL8,

[0699] 2990 S100A12; 477. N0S2, DU0XA2, AVPI1, LUCAT1, CCL4, CXCL8; 478. N0S2, DU0XA2, AVPI1, LUCAT1, CCL4, S100A12; 479. N0S2, DU0XA2, AVPI1, LUCAT1, CXCL8, S100A12; 480. N0S2, DU0XA2, AVPI1, CCL4, CXCL8, S100A12; 481. N0S2, DU0XA2, HCAR3, CALR, LUCAT1, CCL4; 482. N0S2, DU0XA2, HCAR3, CALR, LUCAT1, CXCL8; 483. N0S2, DU0XA2, HCAR3, CALR, LUCAT1, S100A12; 484. N0S2,

[0700] 81

[0701] 4935-6038-7201 , v. 2 DU0XA2, HCAR3, CALR, CCL4, CXCL8; 485. N0S2, DU0XA2, HCAR3, CALR, CCL4, S100A12; 486. N0S2,

[0702] 2995 DU0XA2, HCAR3, CALR, CXCL8, S100A12; 487. N0S2, DU0XA2, HCAR3, LUCAT1, CCL4, CXCL8; 488. N0S2, DU0XA2, HCAR3, LUCAT1, CCL4, S100A12; 489. N0S2, DU0XA2, HCAR3, LUCAT1, CXCL8, S100A12; 490. N0S2, DU0XA2, HCAR3, CCL4, CXCL8, S100A12; 491. N0S2, DU0XA2, CALR, LUCAT1, CCL4, CXCL8; 492. N0S2, DU0XA2, CALR, LUCAT1, CCL4, S100A12; 493. N0S2, DU0XA2, CALR, LUCAT1, CXCL8, S100A12; 494. N0S2, DU0XA2, CALR, CCL4, CXCL8, S100A12; 495. N0S2, DU0XA2,

[0703] 3000 LUCAT1, CCL4, CXCL8, S100A12; 496. N0S2, MMP2, IGHG1, PRPS1, CSF3, CXCR1; 497. N0S2, MMP2, IGHG1, PRPS1, CSF3, AVPI1; 498. N0S2, MMP2, IGHG1, PRPS1, CSF3, HCAR3; 499. N0S2, MMP2, IGHG1, PRPS1, CSF3, CALR; 500. N0S2, MMP2, IGHG1, PRPS1, CSF3, LUCAT1; 501. N0S2, MMP2, IGHG1, PRPS1, CSF3, CCL4; 502. N0S2, MMP2, IGHG1, PRPS1, CSF3, CXCL8; 503. N0S2, MMP2, IGHG1, PRPS1, CSF3, S100A12; 504. N0S2, MMP2, IGHG1, PRPS1, CXCR1, AVPI; 505. N0S2, MMP2,

[0704] 3005 IGHG1, PRPS1, CXCR1, HCAR3; 506. N0S2, MMP2, IGHG1, PRPS1, CXCR1, CALR; 507. N0S2, MMP2, IGHG1, PRPS1, CXCR1, LUCAT1; 508. N0S2, MMP2, IGHG1, PRPS1, CXCR1, CCL4; 509. N0S2, MMP2, IGHG1, PRPS1, CXCR1, CXCL8; 510. N0S2, MMP2, IGHG1, PRPS1, CXCR1, S100A12; 511. N0S2, MMP2, IGHG1, PRPS1, AVPI1, HCAR3; 512. N0S2, MMP2, IGHG1, PRPS1, AVPI1, CALR; 513. N0S2, MMP2, IGHG1, PRPS1, AVPI1, LUCAT1; 514. N0S2, MMP2, IGHG1, PRPS1, AVPI1, CCL4; 515. N0S2, MMP2,

[0705] 3010 IGHG1, PRPS1, AVPI1, CXCL8; 516. N0S2, MMP2, IGHG1, PRPS1, AVPI1, S100A12; 517. N0S2, MMP2, IGHG1, PRPS1, HCAR3, CALR; 518. N0S2, MMP2, IGHG1, PRPS1, HCAR3, LUCAT1; 519. N0S2, MMP2, IGHG1, PRPS1, HCAR3, CCL4; 520. N0S2, MMP2, IGHG1, PRPS1, HCAR3, CXCL8; 521. N0S2, MMP2, IGHG1, PRPS1, HCAR3, S100A12; 522. N0S2, MMP2, IGHG1, PRPS1, CALR, LUCAT1; 523. N0S2, MMP2, IGHG1, PRPS1, CALR, CCL4; 524. N0S2, MMP2, IGHG1, PRPS1, CALR, CXCL8; 525. N0S2, MMP2,

[0706] 3015 IGHG1, PRPS1, CALR, S100A12; 526. N0S2, MMP2, IGHG1, PRPS1, LUCAT1, CCL4; 527. N0S2, MMP2, IGHG1, PRPS1, LUCAT1, CXCL8; 528. N0S2, MMP2, IGHG1, PRPS1, LUCAT1, S100A12; 529. N0S2, MMP2, IGHG1, PRPS1, CCL4, CXCL8; 530. N0S2, MMP2, IGHG1, PRPS1, CCL4, S100A12; 531. N0S2, MMP2, IGHG1, PRPS1, CXCL8, S100A12; 532. N0S2, MMP2, IGHG1, CSF3, CXCR1, AVPI1; 533. N0S2, MMP2, IGHG1, CSF3, CXCR1, HCAR3; 534. N0S2, MMP2, IGHG1, CSF3, CXCR1, CALR; 535. N0S2,

[0707] 3020 MMP2, IGHG1, CSF3, CXCR1, LUCAT1; 536. N0S2, MMP2, IGHG1, CSF3, CXCR1, CCL4; 537. N0S2, MMP2, IGHG1, CSF3, CXCR1, CXCL8; 538. N0S2, MMP2, IGHG1, CSF3, CXCR1, S100A12; 539. N0S2, MMP2, IGHG1, CSF3, AVPI1, HCAR3; 540. N0S2, MMP2, IGHG1, CSF3, AVPI1, CALR; 541. N0S2, MMP2, IGHG1, CSF3, AVPI1, LUCAT1; 542. N0S2, MMP2, IGHG1, CSF3, AVPI1, CCL4; 543. N0S2, MMP2, IGHG1, CSF3, AVPI1, CXCL8; 544. N0S2, MMP2, IGHG1, CSF3, AVPI1, S100A12; 545. N0S2, MMP2,

[0708] 82

[0709] 4935-6038-7201 , v. 2 3025 IGHG1, CSF3, HCAR3, CALR; 546. N0S2, MMP2, IGHG1, CSF3, HCAR3, LUCAT1; 547. N0S2, MMP2, IGHG1, CSF3, HCAR3, CCL4; 548. N0S2, MMP2, IGHG1, CSF3, HCAR3, CXCL8; 549. N0S2, MMP2, IGHG1, CSF3, HCAR3, S100A12; 550. N0S2, MMP2, IGHG1, CSF3, CALR, LUCAT1; 551. N0S2, MMP2, IGHG1, CSF3, CALR, CCL4; 552. N0S2, MMP2, IGHG1, CSF3, CALR, CXCL8; 553. N0S2, MMP2, IGHG1, CSF3, CALR, S100A12; 554. N0S2, MMP2, IGHG1, CSF3, LUCAT1, CCL4; 555. N0S2, MMP2, IGHG1,

[0710] 3030 CSF3, LUCAT1, CXCL8; 556. N0S2, MMP2, IGHG1, CSF3, LUCAT1, S100A12; 557. N0S2, MMP2, IGHG1, CSF3, CCL4, CXCL8; 558. N0S2, MMP2, IGHG1, CSF3, CCL4, S100A12; 559. N0S2, MMP2, IGHG1, CSF3, CXCL8, S100A12; 560. N0S2, MMP2, IGHG1, CXCR1, AVPI1, HCAR3; 561. N0S2, MMP2, IGHG1, CXCR1, AVPI1, CALR; 562. N0S2, MMP2, IGHG1, CXCR1, AVPI1, LUCAT1; 563. N0S2, MMP2, IGHG1, CXCR1, AVPI1, CCL4; 564. N0S2, MMP2, IGHG1, CXCR1, AVPI1, CXCL8; 565. N0S2, MMP2, IGHG1, CXCR1,

[0711] 3035 AVPI1, S100A12; 566. N0S2, MMP2, IGHG1, CXCR1, HCAR3, CALR; 567. N0S2, MMP2, IGHG1, CXCR1, HCAR3, LUCAT1; 568. N0S2, MMP2, IGHG1, CXCR1, HCAR3, CCL4; 569. N0S2, MMP2, IGHG1, CXCR1, HCAR3, CXCL8; 570. N0S2, MMP2, IGHG1, CXCR1, HCAR3, S100A12; 571. N0S2, MMP2, IGHG1, CXCR1, CALR, LUCAT1; 572. N0S2, MMP2, IGHG1, CXCR1, CALR, CCL4; 573. N0S2, MMP2, IGHG1, CXCR1, CALR, CXCL8; 574. N0S2, MMP2, IGHG1, CXCR1, CALR, S100A12; 575. N0S2, MMP2, IGHG1,

[0712] 3040 CXCR1, LUCAT1, CCL4; 576. N0S2, MMP2, IGHG1, CXCR1, LUCAT1, CXCL8; 577. N0S2, MMP2, IGHG1, CXCR1, LUCAT1, S100A12; 578. N0S2, MMP2, IGHG1, CXCR1, CCL4, CXCL8; 579. N0S2, MMP2, IGHG1, CXCR1, CCL4, S100A12; 580. N0S2, MMP2, IGHG1, CXCR1, CXCL8, S100A12; 581. N0S2, MMP2, IGHG1, AVPI1, HCAR3, CALR; 582. N0S2, MMP2, IGHG1, AVPI1, HCAR3, LUCAT1; 583. N0S2, MMP2, IGHG1, AVPI1, HCAR3, CCL4; 584. N0S2, MMP2, IGHG1, AVPI1, HCAR3, CXCL8; 585. N0S2, MMP2, IGHG1,

[0713] 3045 AVPI1, HCAR3, S100A12; 586. N0S2, MMP2, IGHG1, AVPI1, CALR, LUCAT1; 587. N0S2, MMP2, IGHG1, AVPI1, CALR, CCL4; 588. N0S2, MMP2, IGHG1, AVPI1, CALR, CXCL8; 589. N0S2, MMP2, IGHG1, AVPI1, CALR, S100A12; 590. N0S2, MMP2, IGHG1, AVPI1, LUCAT1, CCL4; 591. N0S2, MMP2, IGHG1, AVPI1, LUCAT1, CXCL8; 592. N0S2, MMP2, IGHG1, AVPI1, LUCAT1, S100A12; 593. N0S2, MMP2, IGHG1, AVPI1, CCL4, CXCL8; 594. N0S2, MMP2, IGHG1, AVPI1, CCL4, S100A12; 595. N0S2, MMP2, IGHG1,

[0714] 3050 AVPI1, CXCL8, S100A12; 596. N0S2, MMP2, IGHG1, HCAR3, CALR, LUCAT1; 597. N0S2, MMP2, IGHG1, HCAR3, CALR, CCL4; 598. N0S2, MMP2, IGHG1, HCAR3, CALR, CXCL8; 599. N0S2, MMP2, IGHG1, HCAR3, CALR, S100A12; 600. N0S2, MMP2, IGHG1, HCAR3, LUCAT1, CCL4; 601. N0S2, MMP2, IGHG1, HCAR3, LUCAT1, CXCL8; 602. N0S2, MMP2, IGHG1, HCAR3, LUCAT1, S100A12; 603. N0S2, MMP2, IGHG1, HCAR3, CCL4, CXCL8; 604. N0S2, MMP2, IGHG1, HCAR3, CCL4, S100A12; 605. N0S2, MMP2,

[0715] 3055 IGHG1, HCAR3, CXCL8, S100A12; 606. N0S2, MMP2, IGHG1, CALR, LUCAT1, CCL4; 607. N0S2, MMP2,

[0716] 83

[0717] 4935-6038-7201 , v. 2 IGHG1, CALR, LUCAT1, CXCL8; 608. N0S2, MMP2, IGHG1, CALR, LUCAT1, S100A12; 609. N0S2, MMP2, IGHG1, CALR, CCL4, CXCL8; 610. N0S2, MMP2, IGHG1, CALR, CCL4, S100A12; 611. N0S2, MMP2, IGHG1, CALR, CXCL8, S100A12; 612. N0S2, MMP2, IGHG1, LUCAT1, CCL4, CXCL8; 613. N0S2, MMP2, IGHG1, LUCAT1, CCL4, S100A12; 614. N0S2, MMP2, IGHG1, LUCAT1, CXCL8, S100A12; 615. N0S2,

[0718] 3060 MMP2, IGHG1, CCL4, CXCL8, S100A12; 616. N0S2, MMP2, PRPS1, CSF3, CXCR1, AVPI1; 617. N0S2, MMP2, PRPS1, CSF3, CXCR1, HCAR3; 618. N0S2, MMP2, PRPS1, CSF3, CXCR1, CALR; 619. N0S2, MMP2, PRPS1, CSF3, CXCR1, LUCAT1; 620. N0S2, MMP2, PRPS1, CSF3, CXCR1, CCL4; 621. N0S2, MMP2, PRPS1, CSF3, CXCR1, CXCL8; 622. N0S2, MMP2, PRPS1, CSF3, CXCR1, S100A12; 623. N0S2, MMP2, PRPS1, CSF3, AVPI1, HCAR3; 624. N0S2, MMP2, PRPS1, CSF3, AVPI1, CALR; 625. N0S2, MMP2,

[0719] 3065 PRPS1, CSF3, AVPI1, LUCAT1; 626. N0S2, MMP2, PRPS1, CSF3, AVPI1, CCL4; 627. N0S2, MMP2, PRPS1, CSF3, AVPI1, CXCL8; 628. N0S2, MMP2, PRPS1, CSF3, AVPI1, S100A12; 629. N0S2, MMP2, PRPS1, CSF3, HCAR3, CALR; 630. N0S2, MMP2, PRPS1, CSF3, HCAR3, LUCAT1; 631. N0S2, MMP2, PRPS1, CSF3, HCAR3, CCL4; 632. N0S2, MMP2, PRPS1, CSF3, HCAR3, CXCL8; 633. N0S2, MMP2, PRPS1, CSF3, HCAR3, S100A12; 634. N0S2, MMP2, PRPS1, CSF3, CALR, LUCAT1; 635. N0S2, MMP2,

[0720] 3070 PRPS1, CSF3, CALR, CCL4; 636. N0S2, MMP2, PRPS1, CSF3, CALR, CXCL8; 637. N0S2, MMP2, PRPS1, CSF3, CALR, S100A12; 638. N0S2, MMP2, PRPS1, CSF3, LUCAT1, CCL4; 639. N0S2, MMP2, PRPS1, CSF3, LUCAT1, CXCL8; 640. N0S2, MMP2, PRPS1, CSF3, LUCAT1, S100A12; 641. N0S2, MMP2, PRPS1, CSF3, CCL4, CXCL8; 642. N0S2, MMP2, PRPS1, CSF3, CCL4, S100A12; 643. N0S2, MMP2, PRPS1, CSF3, CXCL8, S100A12; 644. N0S2, MMP2, PRPS1, CXCR1, AVPI1, HCAR3; 645. N0S2, MMP2, PRPS1, CXCR1,

[0721] 3075 AVPI1, CALR; 646. N0S2, MMP2, PRPS1, CXCR1, AVPI1, LUCAT1; 647. N0S2, MMP2, PRPS1, CXCR1, AVPI1, CCL4; 648. N0S2, MMP2, PRPS1, CXCR1, AVPI1, CXCL8; 649. N0S2, MMP2, PRPS1, CXCR1, AVPI1, S100A12; 650. N0S2, MMP2, PRPS1, CXCR1, HCAR3, CALR; 651. N0S2, MMP2, PRPS1, CXCR1, HCAR3, LUCAT1; 652. N0S2, MMP2, PRPS1, CXCR1, HCAR3, CCL4; 653. N0S2, MMP2, PRPS1, CXCR1, HCAR3, CXCL8; 654. N0S2, MMP2, PRPS1, CXCR1, HCAR3, S100A12; 655. N0S2, MMP2, PRPS1, CXCR1,

[0722] 3080 CALR, LUCAT1; 656. N0S2, MMP2, PRPS1, CXCR1, CALR, CCL4; 657. N0S2, MMP2, PRPS1, CXCR1, CALR, CXCL8; 658. N0S2, MMP2, PRPS1, CXCR1, CALR, S100A12; 659. N0S2, MMP2, PRPS1, CXCR1, LUCAT1, CCL4; 660. N0S2, MMP2, PRPS1, CXCR1, LUCAT1, CXCL8; 661. N0S2, MMP2, PRPS1, CXCR1, LUCAT1, S100A12; 662. N0S2, MMP2, PRPS1, CXCR1, CCL4, CXCL8; 663. N0S2, MMP2, PRPS1, CXCR1, CCL4, S100A12; 664. N0S2, MMP2, PRPS1, CXCR1, CXCL8, S100A12; 665. N0S2, MMP2, PRPS1, AVPI1,

[0723] 3085 HCAR3, CALR; 666. N0S2, MMP2, PRPS1, AVPI1, HCAR3, LUCAT1; 667. N0S2, MMP2, PRPS1, AVPI1, HCAR3, CCL4; 668. N0S2, MMP2, PRPS1, AVPI1, HCAR3, CXCL8; 669. N0S2, MMP2, PRPS1, AVPI1,

[0724] 84

[0725] 4935-6038-7201 , v. 2 HCAR3, S100A12; 670. N0S2, MMP2, PRPS1, AVPI1, CALR, LUCAT1; 671. N0S2, MMP2, PRPS1, AVPI1, CALR, CCL4; 672. N0S2, MMP2, PRPS1, AVPI1, CALR, CXCL8; 673. N0S2, MMP2, PRPS1, AVPI1, CALR, S100A12; 674. N0S2, MMP2, PRPS1, AVPI1, LUCAT1, CCL4; 675. N0S2, MMP2, PRPS1, AVPI1, LUCAT1,

[0726] 3090 CXCL8; 676. N0S2, MMP2, PRPS1, AVPI1, LUCAT1, S100A12; 677. N0S2, MMP2, PRPS1, AVPI1, CCL4, CXCL8; 678. N0S2, MMP2, PRPS1, AVPI1, CCL4, S100A12; 679. N0S2, MMP2, PRPS1, AVPI1, CXCL8, S100A12; 680. N0S2, MMP2, PRPS1, HCAR3, CALR, LUCAT1; 681. N0S2, MMP2, PRPS1, HCAR3, CALR, CCL4; 682. N0S2, MMP2, PRPS1, HCAR3, CALR, CXCL8; 683. N0S2, MMP2, PRPS1, HCAR3, CALR, S100A12; 684. N0S2, MMP2, PRPS1, HCAR3, LUCAT1, CCL4; 685. N0S2, MMP2, PRPS1, HCAR3,

[0727] 3095 LUCAT1, CXCL8; 686. N0S2, MMP2, PRPS1, HCAR3, LUCAT1, S100A12; 687. N0S2, MMP2, PRPS1, HCAR3, CCL4, CXCL8; 688. N0S2, MMP2, PRPS1, HCAR3, CCL4, S100A12; 689. N0S2, MMP2, PRPS1, HCAR3, CXCL8, S100A12; 690. N0S2, MMP2, PRPS1, CALR, LUCAT1, CCL4; 691. N0S2, MMP2, PRPS1, CALR, LUCAT1, CXCL8; 692. N0S2, MMP2, PRPS1, CALR, LUCAT1, S100A12; 693. N0S2, MMP2, PRPS1, CALR, CCL4, CXCL8; 694. N0S2, MMP2, PRPS1, CALR, CCL4, S100A12; 695. N0S2, MMP2, PRPS1,

[0728] 3100 CALR, CXCL8, S100A12; 696. N0S2, MMP2, PRPS1, LUCAT1, CCL4, CXCL8; 697. N0S2, MMP2, PRPS1, LUCAT1, CCL4, S100A12; 698. N0S2, MMP2, PRPS1, LUCAT1, CXCL8, S100A12; 699. N0S2, MMP2, PRPS1, CCL4, CXCL8, S100A12; 700. N0S2, MMP2, CSF3, CXCR1, AVPI1, HCAR3; 701. N0S2, MMP2, CSF3, CXCR1, AVPI1, CALR; 702. N0S2, MMP2, CSF3, CXCRL AVPIl, LUCAT1; 703. N0S2, MMP2, CSF3, CXCRL AVPIl, CCL4; 704. N0S2, MMP2, CSF3, CXCR1, AVPI1, CXCL8; 705. N0S2, MMP2, CSF3,

[0729] 3105 CXCRL AVPIl, S100A12; 706. N0S2, MMP2, CSF3, CXCR1, HCAR3, CALR; 707. N0S2, MMP2, CSF3, CXCR1, HCAR3, LUCAT1; 708. N0S2, MMP2, CSF3, CXCR1, HCAR3, CCL4; 709. N0S2, MMP2, CSF3, CXCR1, HCAR3, CXCL8; 710. N0S2, MMP2, CSF3, CXCR1, HCAR3, S100A12; 711. N0S2, MMP2, CSF3, CXCR1, CALR, LUCAT1; 712. N0S2, MMP2, CSF3, CXCR1, CALR, CCL4; 713. N0S2, MMP2, CSF3, CXCR1, CALR, CXCL8; 714. N0S2, MMP2, CSF3, CXCR1, CALR, S100A12; 715. N0S2, MMP2, CSF3,

[0730] 3110 CXCR1, LUCAT1, CCL4; 716. N0S2, MMP2, CSF3, CXCR1, LUCAT1, CXCL8; 717. N0S2, MMP2, CSF3, CXCR1, LUCAT1, S100A12; 718. N0S2, MMP2, CSF3, CXCR1, CCL4, CXCL8; 719. N0S2, MMP2, CSF3, CXCR1, CCL4, S100A12; 720. N0S2, MMP2, CSF3, CXCR1, CXCL8, S100A12; 721. N0S2, MMP2, CSF3, AVPI1, HCAR3, CALR; 722. N0S2, MMP2, CSF3, AVPI1, HCAR3, LUCAT1; 723. N0S2, MMP2, CSF3, AVPI1, HCAR3, CCL4; 724. N0S2, MMP2, CSF3, AVPI1, HCAR3, CXCL8; 725. N0S2, MMP2, CSF3, AVPI1,

[0731] 3115 HCAR3, S100A12; 726. N0S2, MMP2, CSF3, AVPI1, CALR, LUCAT1; 727. N0S2, MMP2, CSF3, AVPI1, CALR, CCL4; 728. N0S2, MMP2, CSF3, AVPI1, CALR, CXCL8; 729. N0S2, MMP2, CSF3, AVPI1, CALR, S100A12; 730. N0S2, MMP2, CSF3, AVPI1, LUCAT1, CCL4; 731. N0S2, MMP2, CSF3, AVPI1, LUCAT1,

[0732] 85

[0733] 4935-6038-7201 , v. 2 CXCL8; 732. N0S2, MMP2, CSF3, AVPI1, LUCAT1, S100A12; 733. NOS2, MMP2, CSF3, AVPI1, CCL4, CXCL8; 734. N0S2, MMP2, CSF3, AVPI1, CCL4, S100A12; 735. N0S2, MMP2, CSF3, AVPI1, CXCL8,

[0734] 3120 S100A12; 736. N0S2, MMP2, CSF3, HCAR3, CALR, LUCAT1; 737. N0S2, MMP2, CSF3, HCAR3, CALR, CCL4; 738. N0S2, MMP2, CSF3, HCAR3, CALR, CXCL8; 739. N0S2, MMP2, CSF3, HCAR3, CALR, S100A12; 740. N0S2, MMP2, CSF3, HCAR3, LUCAT1, CCL4; 741. N0S2, MMP2, CSF3, HCAR3, LUCAT1, CXCL8; 742. N0S2, MMP2, CSF3, HCAR3, LUCAT1, S100A12; 743. N0S2, MMP2, CSF3, HCAR3, CCL4, CXCL8; 744. N0S2, MMP2, CSF3, HCAR3, CCL4, S100A12; 745. N0S2, MMP2, CSF3, HCAR3, CXCL8,

[0735] 3125 S100A12; 746. N0S2, MMP2, CSF3, CALR, LUCAT1, CCL4; 747. N0S2, MMP2, CSF3, CALR, LUCAT1, CXCL8; 748. N0S2, MMP2, CSF3, CALR, LUCAT1, S100A12; 749. N0S2, MMP2, CSF3, CALR, CCL4, CXCL8; 750. N0S2, MMP2, CSF3, CALR, CCL4, S100A12; 751. N0S2, MMP2, CSF3, CALR, CXCL8, S100A12; 752. N0S2, MMP2, CSF3, LUCAT1, CCL4, CXCL8; 753. N0S2, MMP2, CSF3, LUCAT1, CCL4, S100A12; 754. N0S2, MMP2, CSF3, LUCAT1, CXCL8, S100A12; 755. N0S2, MMP2, CSF3, CCL4, CXCL8,

[0736] 3130 S100A12; 756. N0S2, MMP2, CXCR1, AVPI1, HCAR3, CALR; 757. N0S2, MMP2, CXCR1, AVPI1, HCAR3, LUCAT1; 758. N0S2, MMP2, CXCR1, AVPI1, HCAR3, CCL4; 759. N0S2, MMP2, CXCR1, AVPI1, HCAR3, CXCL8; 760. N0S2, MMP2, CXCR1, AVPI1, HCAR3, S100A12; 761. N0S2, MMP2, CXCR1, AVPI1, CALR, LUCAT1; 762. N0S2, MMP2, CXCR1, AVPI1, CALR, CCL4; 763. N0S2, MMP2, CXCR1, AVPI1, CALR, CXCL8; 764. N0S2, MMP2, CXCR1, AVPI1, CALR, S100A12; 765. N0S2, MMP2, CXCR1, AVPI1, LUCAT1,

[0737] 3135 CCL4; 766. N0S2, MMP2, CXCR1, AVPI1, LUCAT1, CXCL8; 767. N0S2, MMP2, CXCR1, AVPI1, LUCAT1, S100A12; 768. N0S2, MMP2, CXCR1, AVPI1, CCL4, CXCL8; 769. N0S2, MMP2, CXCR1, AVPI1, CCL4, S100A12; 770. N0S2, MMP2, CXCR1, AVPI1, CXCL8, S100A12; 771. N0S2, MMP2, CXCR1, HCAR3, CALR, LUCAT1; 772. N0S2, MMP2, CXCR1, HCAR3, CALR, CCL4; 773. N0S2, MMP2, CXCR1, HCAR3, CALR, CXCL8; 774. N0S2, MMP2, CXCR1, HCAR3, CALR, S100A12; 775. N0S2, MMP2, CXCR1, HCAR3,

[0738] 3140 LUCAT1, CCL4; 776. N0S2, MMP2, CXCR1, HCAR3, LUCAT1, CXCL8; 777. N0S2, MMP2, CXCR1, HCAR3, LUCAT1, S100A12; 778. N0S2, MMP2, CXCR1, HCAR3, CCL4, CXCL8; 779. N0S2, MMP2, CXCR1, HCAR3, CCL4, S100A12; 780. N0S2, MMP2, CXCR1, HCAR3, CXCL8, S100A12; 781. N0S2, MMP2, CXCR1, CALR, LUCAT1, CCL4; 782. N0S2, MMP2, CXCR1, CALR, LUCAT1, CXCL8; 783. N0S2, MMP2, CXCR1, CALR, LUCAT1, S100A12; 784. N0S2, MMP2, CXCR1, CALR, CCL4, CXCL8; 785. N0S2,

[0739] 3145 MMP2, CXCR1, CALR, CCL4, S100A12; 786. N0S2, MMP2, CXCR1, CALR, CXCL8, S100A12; 787. N0S2, MMP2, CXCR1, LUCAT1, CCL4, CXCL8; 788. N0S2, MMP2, CXCR1, LUCAT1, CCL4, S100A12; 789. N0S2, MMP2, CXCR1, LUCAT1, CXCL8, S100A12; 790. NOS2, MMP2, CXCR1, CCL4, CXCL8, S100A12; 791. N0S2, MMP2, AVPI1, HCAR3, CALR, LUCAT1; 792. N0S2, MMP2, AVPI1, HCAR3, CALR, CCL4; 793.

[0740] 86

[0741] 4935-6038-7201 , v. 2 N0S2, MMP2, AVPI1, HCAR3, CALR, CXCL8; 794. N0S2, MMP2, AVPI1, HCAR3, CALR, S100A12; 795.

[0742] 3150 N0S2, MMP2, AVPI1, HCAR3, LUCAT1, CCL4; 796. N0S2, MMP2, AVPI1, HCAR3, LUCAT1, CXCL8; 797.

[0743] N0S2, MMP2, AVPI1, HCAR3, LUCAT1, S100A12; 798. N0S2, MMP2, AVPI1, HCAR3, CCL4, CXCL8; 799.

[0744] N0S2, MMP2, AVPI1, HCAR3, CCL4, S100A12; 800. N0S2, MMP2, AVPI1, HCAR3, CXCL8, S100A12; 801.

[0745] N0S2, MMP2, AVPI1, CALR, LUCAT1, CCL4; 802. N0S2, MMP2, AVPI1, CALR, LUCAT1, CXCL8; 803.

[0746] N0S2, MMP2, AVPI1, CALR, LUCAT1, S100A12; 804. N0S2, MMP2, AVPI1, CALR, CCL4, CXCL8; 805.

[0747] 3155 N0S2, MMP2, AVPI1, CALR, CCL4, S100A12; 806. N0S2, MMP2, AVPI1, CALR, CXCL8, S100A12; 807.

[0748] N0S2, MMP2, AVPI1, LUCAT1, CCL4, CXCL8; 808. N0S2, MMP2, AVPI1, LUCAT1, CCL4, S100A12; 809.

[0749] N0S2, MMP2, AVPI1, LUCAT1, CXCL8, S100A12; 810. N0S2, MMP2, AVPI1, CCL4, CXCL8, S100A12; 811.

[0750] N0S2, MMP2, HCAR3, CALR, LUCAT1, CCL4; 812. N0S2, MMP2, HCAR3, CALR, LUCAT1, CXCL8; 813.

[0751] N0S2, MMP2, HCAR3, CALR, LUCAT1, S100A12; 814. N0S2, MMP2, HCAR3, CALR, CCL4, CXCL8; 815.

[0752] 3160 N0S2, MMP2, HCAR3, CALR, CCL4, S100A12; 816. N0S2, MMP2, HCAR3, CALR, CXCL8, S100A12; 817.

[0753] N0S2, MMP2, HCAR3, LUCAT1, CCL4, CXCL8; 818. N0S2, MMP2, HCAR3, LUCAT1, CCL4, S100A12; 819.

[0754] N0S2, MMP2, HCAR3, LUCAT1, CXCL8, S100A12; 820. N0S2, MMP2, HCAR3, CCL4, CXCL8, S100A12;

[0755] 821. N0S2, MMP2, CALR, LUCAT1, CCL4, CXCL8; 822. N0S2, MMP2, CALR, LUCAT1, CCL4, S100A12;

[0756] 823. N0S2, MMP2, CALR, LUCAT1, CXCL8, S100A12; 824. N0S2, MMP2, CALR, CCL4, CXCL8, S100A12;

[0757] 3165 825. N0S2, MMP2, LUCAT1, CCL4, CXCL8, S100A12; 826. N0S2, IGHG1, PRPS1, CSF3, CXCR1, AVPI1;

[0758] 827. N0S2, IGHG1, PRPS1, CSF3, CXCR1, HCAR3; 828. N0S2, IGHG1, PRPS1, CSF3, CXCR1, CALR; 829.

[0759] N0S2, IGHG1, PRPS1, CSF3, CXCR1, LUCAT1; 830. N0S2, IGHG1, PRPS1, CSF3, CXCR1, CCL4; 831.

[0760] N0S2, IGHG1, PRPS1, CSF3, CXCR1, CXCL8; 832. N0S2, IGHG1, PRPS1, CSF3, CXCR1, S100A12; 833.

[0761] N0S2, IGHG1, PRPS1, CSF3, AVPI1, HCAR3; 834. N0S2, IGHG1, PRPS1, CSF3, AVPI1, CALR; 835. N0S2,

[0762] 3170 IGHG1, PRPS1, CSF3, AVPI1, LUCAT1; 836. N0S2, IGHG1, PRPS1, CSF3, AVPI1, CCL4; 837. N0S2,

[0763] IGHG1, PRPS1, CSF3, AVPI1, CXCL8; 838. N0S2, IGHG1, PRPS1, CSF3, AVPI1, S100A12; 839. N0S2,

[0764] IGHG1, PRPS1, CSF3, HCAR3, CALR; 840. N0S2, IGHG1, PRPS1, CSF3, HCAR3, LUCAT1; 841. N0S2,

[0765] IGHG1, PRPS1, CSF3, HCAR3, CCL4; 842. N0S2, IGHG1, PRPS1, CSF3, HCAR3, CXCL8; 843. N0S2,

[0766] IGHG1, PRPS1, CSF3, HCAR3, S100A12; 844. N0S2, IGHG1, PRPS1, CSF3, CALR, LUCAT1; 845. N0S2,

[0767] 3175 IGHG1, PRPS1, CSF3, CALR, CCL4; 846. N0S2, IGHG1, PRPS1, CSF3, CALR, CXCL8; 847. N0S2, IGHG1,

[0768] PRPS1, CSF3, CALR, S100A12; 848. N0S2, IGHG1, PRPS1, CSF3, LUCAT1, CCL4; 849. N0S2, IGHG1,

[0769] PRPS1, CSF3, LUCAT1, CXCL8; 850. N0S2, IGHG1, PRPS1, CSF3, LUCAT1, S100A12; 851. N0S2, IGHG1,

[0770] PRPS1, CSF3, CCL4, CXCL8; 852. N0S2, IGHG1, PRPS1, CSF3, CCL4, S100A12; 853. N0S2, IGHG1,

[0771] PRPS1, CSF3, CXCL8, S100A12; 854. N0S2, IGHG1, PRPS1, CXCR1, AVPI1, HCAR3; 855. N0S2, IGHG1,

[0772] 87

[0773] 4935-6038-7201 , v. 2 3180 PRPS1, CXCR1, AVPI1, CALR; 856. N0S2, IGHG1, PRPS1, CXCR1, AVPI1, LUCAT1; 857. N0S2, IGHG1,

[0774] PRPS1, CXCR1, AVPI1, CCL4; 858. N0S2, IGHG1, PRPS1, CXCR1, AVPI1, CXCL8; 859. N0S2, IGHG1, PRPS1, CXCR1, AVPI1, S100A12; 860. N0S2, IGHG1, PRPS1, CXCR1, HCAR3, CALR; 861. N0S2, IGHG1, PRPS1, CXCR1, HCAR3, LUCAT1; 862. N0S2, IGHG1, PRPS1, CXCR1, HCAR3, CCL4; 863. N0S2, IGHG1,

[0775] PRPS1, CXCR1, HCAR3, CXCL8; 864. N0S2, IGHG1, PRPS1, CXCR1, HCAR3, S100A12; 865. N0S2,

[0776] 3185 IGHG1, PRPS1, CXCR1, CALR, LUCAT1; 866. N0S2, IGHG1, PRPS1, CXCR1, CALR, CCL4; 867. N0S2,

[0777] IGHG1, PRPS1, CXCR1, CALR, CXCL8; 868. N0S2, IGHG1, PRPS1, CXCR1, CALR, S100A12; 869. N0S2,

[0778] IGHG1, PRPS1, CXCR1, LUCAT1, CCL4; 870. N0S2, IGHG1, PRPS1, CXCR1, LUCAT1, CXCL8; 871. N0S2, IGHG1, PRPS1, CXCR1, LUCAT1, S100A12; 872. N0S2, IGHG1, PRPS1, CXCR1, CCL4, CXCL8; 873. N0S2, IGHG1, PRPS1, CXCR1, CCL4, S100A12; 874. N0S2, IGHG1, PRPS1, CXCR1, CXCL8, S100A12; 875. N0S2,

[0779] 3190 IGHG1, PRPS1, AVPI1, HCAR3, CALR; 876. N0S2, IGHG1, PRPS1, AVPI1, HCAR3, LUCAT1; 877. N0S2,

[0780] IGHG1, PRPS1, AVPI1, HCAR3, CCL4; 878. N0S2, IGHG1, PRPS1, AVPI1, HCAR3, CXCL8; 879. N0S2,

[0781] IGHG1, PRPS1, AVPI1, HCAR3, S100A12; 880. N0S2, IGHG1, PRPS1, AVPI1, CALR, LUCAT1; 881. N0S2,

[0782] IGHG1, PRPS1, AVPI1, CALR, CCL4; 882. N0S2, IGHG...

Claims

CLAIMS1. A method for treating a subject with an inflammatory bowel disease, comprising:5265 obtaining a biological sample from the subject with inflammatory bowel disease; measuring gene expression levels of one or more genes selected from the group consisting of: DUOXA2, LUCAT1, CXCR1, CCL4, MMP1, \I\IP2. CSF3, HCAR3, IL1B, CXCL8, S100A12, SELE, ITPRIP, PRPS1,AVPI1, NOS2, ODC1, IL6, NFKBIZ, IGHG1, and CALR in the biological sample; applying an algorithm to the measured gene expression levels to generate a PDE4 Inhibitor Resistance 70 Metric; classifying the subject as a likely responder or non-responder to a PDE4 inhibitor based on a comparison of the PDE4 Inhibitor Resistance Metric with a cut-off value obtained from a pool of research subjects with inflammatory bowel disease; and administering a PDE4 inhibitor drug treatment to the subject if identified as a responder. 75 2. The method of claim 1, wherein the PDE4 inhibitor is administered to the subject if the PDE4 Inhibitor Resistance Metric is below the cut-off value.

3. The method of claim 1, wherein the expression level of one or more, two or more, three or more, four or more, five or more, or all six genes selected from the group consisting of: DUOXA2, LUCAT1, CXCR1, CCL4, MMP1 wAMMP2 is measured. 80 4. The method of claim 1, wherein the expression level of one or more, two or more, three or more, four or more, five or more, or all six genes selected from the group consisting of: CSF3, DUOXA2, HCAR3, CCL4, IL1B and CXCL8 is measured.

5. The method of claim 1, wherein the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CSF3, CXCR1, S100A12, LUCAT1 85 and SELE is measured.

6. The method of claim 1, wherein the expression level of one or more, two or more, three or more, four or more, or all five genes selected from the group consisting of: CCL4, ITPRIP, PRPS1, A VPI1 and NOS2 is measured.

7. The method of claim 1, wherein the expression level of one or more, two or more, three or 90 more, four or more, or all five genes selected from the group consisting of: ODC1, IL6, ITPRIP, CXCR1 and NOS2 is measured.

8. The method of claim 1, wherein the inflammatory bowel disease is ulcerative colitis.

9. The method of claim 8, wherein the biological sample is a colon sample.

10. The method of claim 1, wherein the algorithm is a multinomial logistic regression algorithm.1574935-6038-7201 , v. 25295 11. A method of determining a PDE4 Inhibitor Resistance Metric and cut-off value for a future subject in need of treatment for an inflammatory bowel disease, comprising: obtaining a data set from a set of reference patients, the data set including expression level data for genes from a sample domain of genes for each reference patient, and an indication as to whether each reference patient was a documented responder or non-responder to a previously-initiated therapeutic intervention;5300 applying machine learning to obtain an algorithm to iteratively determine from the sample domain of genes a ranking and a weight factor for each gene in the sample domain to most accurately predict from the expression level data whether a reference patient would be classified as a responder or a non-responder, as compared to the documented responder or non-responder status in the curated data set, and obtaining a top set of genes containing the highest-ranked genes, wherein the number of genes in the top set of genes is less than the 05 number of genes in the sample domain; obtaining a PDE4 Inhibitor Resistance Metric for each reference patient based on the expression level data and the weight factor for each gene, and a cut-off value to separate the PDE4 Inhibitor Resistance Metric for responding patients and non-responding reference patients; determining, in an iterative manner, from the top set of genes which individual combination of x 10 number of genes, from all possible permutations of x number amongst the top set of genes, most accurately predicts from the expression level data whether a reference patient would be classified as a responder or a non- responder, as compared to the documented responder or non-responder status in the curated data set to obtain a final gene set, wherein x is less than the number of genes in the top gene set; and providing the final gene set to obtain a personalized PDE4 Inhibitor Resistance Metric for the future 15 subject in need of treatment for inflammatory bowel disease based on measured expression levels for the future subject and the weight factor for each gene in the final gene set.

12. The method of claim 11, wherein the inflammatory bowel disease is selected from ulcerative colitis and Crohn's disease, and the previously -initiated therapeutic intervention is administration of a PDE4 inhibitor to the reference patients. 20 13. The method of claim 11, wherein the top set of genes comprises from about 10 to about 30 genes.

14. The method of claim 13, wherein the final gene set comprises from about 4 to about 7 genes.

15. The method of claim 11, wherein the top set of genes includes one or more genes selected from the group consisting of: A VPI1, CALR, CCL4, CSF3, CXCL8, CXCR1, DUOXA2, HCAR3, IGHG1, IL1B, 25 IL6, ITPRIP, LUCAT1,MMP1, \I\IP2. NFKBIZ, NOS2, ODC1, PRPS1, S100A12, and SELE.

16. The method of claim 15, wherein the algorithm is a multinomial logistic regression algorithm.

17. A method for treating a subject with inflammatory bowel disease, comprising: applying machine learning to a data set from reference patients to obtain an algorithm that determines a ranking and weight factor for genes in a sample domain to predict responder or non-responder status;1584935-6038-7201 , v. 25330 obtaining a final gene set from the sample domain through iterative analysis; obtaining a biological sample from the subject with inflammatory bowel disease; measuring gene expression levels of each gene in the final gene set; applying the weight factor to the measured gene expression levels to generate a personalized PDE4 Inhibitor Resistance Metric for the subject; 35 classifying the subject as a likely responder or non-responder to a PDE4 inhibitor based on comparison of the personalized PDE4 Inhibitor Resistance Metric with a cut-off value; and administering a PDE4 inhibitor drug treatment to the subject if identified as a likely responder.

18. The method of claim 17, wherein the inflammatory bowel disease is ulcerative colitis.

19. The method of claim 18, wherein the biological sample is a colon sample. 40 20. The method of claim 17, wherein the final gene set comprises from about 4 to about 7 genes selected from the group consisting of: AVPI1, CALR, CCL4, CSF3, CXCL8, CXCR1, DUOXA2, HCAR3, IGHG1, IL1B, IL6, ITPRIP, LUCAT1,MMP1, MMP2, NFKBIZ, NOS2, ODC1, PRPS1, S100A12, and SELF1594935-6038-7201 , v. 2

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