Spatial analysis of whole genome and target genomic DNA
The method of spatial genomic DNA analysis using capture probes with barcodes and domains addresses the lack of spatial information in current sequencing techniques, enabling accurate identification of DNA sequences and their locations within tissues.
WO2026135910A1PCT designated stage Publication Date: 2026-06-2510X GENOMICS INC
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- 10X GENOMICS INC
- Filing Date
- 2025-11-19
- Publication Date
- 2026-06-25
AI Technical Summary
Technical Problem
Current whole genome and targeted genomic DNA sequencing approaches fail to provide spatial and cellular heterogeneity information, as they are typically performed on mixed populations of cells, lacking the ability to link DNA sequences with their spatial positions within tissues.
Method used
A method involving spatial analysis of genomic DNA using capture probes with spatial barcodes and capture domains, combined with genomic DNA amplification and sequencing, to determine the spatial positions and sequences of DNA in biological samples.
Benefits of technology
Provides whole genome and targeted genomic DNA sequencing data with spatial and cellular expression patterns, enabling identification of mutated or altered DNA sequences associated with diseases or conditions.
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Smart Images
Figure US2025056107_25062026_PF_FP_ABST
Abstract
Systems, compositions, methods, and kits for spatial analysis of whole genome DNA, including targeted genomic DNA sequences, are provided. The technology is related to combining genomic DNA sequence analysis with spatial information linking the whole genome and / or targeted genomic DNA sequences to their spatial positions in single cells within biological samples. The spatial analysis of genomic DNA can be used to determine the locations of DNA sequences of interest are present anywhere in an organism's entire genome (whole genome sequence) and to identify locations of any genetic mutations, such as mutations linked to diseases and disorders.
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