Systems and methods for vessel debulking with radiofrequency ablation

The catheter-based system with an expandable support structure and evenly spaced electrode array addresses the challenges of in-stent restenosis by delivering controlled radiofrequency energy for efficient and durable debulking of fibrotic tissue, improving luminal expansion and reducing the need for repeated interventions.

WO2026136530A1PCT designated stage Publication Date: 2026-06-25ALARIS VASCULAR INC
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
ALARIS VASCULAR INC
Filing Date
2025-12-17
Publication Date
2026-06-25

AI Technical Summary

Technical Problem

Current therapies for post-thrombotic syndrome (PTS) due to chronic venous outflow obstruction, such as high-pressure balloons and mechanical atherectomy, face challenges like elastic recoil, vessel injury, and inconsistent outcomes, while surgical bypass is invasive and has limited durability, leading to high rates of in-stent restenosis (ISR) and recurrent pain.

Method used

A catheter-based system with an expandable support structure and evenly spaced electrode array delivers controlled radiofrequency energy to target fibrotic ISR tissue, sparing the scaffold and enhancing fatigue resistance, allowing for repeated deployments and efficient debulking of lesions.

Benefits of technology

The system provides durable luminal expansion and reduces the need for multiple catheters by achieving consistent ablation with controlled thermal remodeling of neointimal tissue, minimizing collateral damage and promoting long-term patency.

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Abstract

A device for treating a target lesion may include an elongate body comprising a tissue modification device on a distal end of the elongate body. The tissue modification device may include an electrode array and an expandable support structure configured to support the electrode array. When expanded, the expandable support structure is configured to space adjacent electrodes of the electrode array at a substantially equal distance. Further, when expanded, the electrode array is configured to generate one or more tissue modification energy fields around the expandable support structure when an electrical current is supplied to the electrode array. A method of treating a target lesion may include advancing a tissue modification device to a target tissue; expanding the tissue modification device to expand an electrode array; and generating a plurality of zones of radiofrequency (RF) fields through at least a part of the electrode array to ablate the target lesion.
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