Heteroaryl compounds and their use in treating diseases such as cancer
Heteroaryl compounds targeting NAMPT activity provide a more effective treatment for cancers, inflammatory disorders, and metabolic disorders by inhibiting NAMPT, reducing cell proliferation and promoting cell death with fewer side effects.
WO2026143213A1PCT designated stage Publication Date: 2026-07-02ALPHINA THERAPEUTICS INC
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- ALPHINA THERAPEUTICS INC
- Filing Date
- 2025-12-26
- Publication Date
- 2026-07-02
Smart Images
Figure US2025061333_02072026_PF_FP_ABST
Abstract
Provided herein are heteroaryl compounds, pharmaceutical compositions, and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, autoimmune disorder, or metabolic disorder. In some embodiments, the heteroaryl compounds are represented by Formula (I), or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., A1, A2, A3, A4, R1A) are as described herein.
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