Synthesis method of tetracycline from bamboo

A novel method synthesizes tetracycline from bamboo through a two-step process, addressing complexity and cost issues in conventional methods while reducing side effects.

WO2026147356A1PCT designated stage Publication Date: 2026-07-09NATCHRUNGSUNKH PHANAWISITTHA

Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
NATCHRUNGSUNKH PHANAWISITTHA
Filing Date
2025-12-23
Publication Date
2026-07-09

AI Technical Summary

Technical Problem

Conventional methods for producing tetracycline are complex, costly, and may cause undesirable side effects, while bamboo, a natural resource, does not naturally contain tetracycline, lacking a known synthesis method.

Method used

A two-step process involving reacting bamboo with a water-based agent for 30 days, followed by air-drying and soaking in 99.9% ethyl alcohol for 30 days to produce tetracycline from bamboo.

Benefits of technology

The method simplifies production, reduces costs, and minimizes side effects by utilizing bamboo as a biological raw material to synthesize tetracycline.

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Abstract

The invention relates to a composition, production method, or synthesis method for obtaining Tetracycline (Chemical formula C22H24N2O8) from bamboo. The raw materials consist of 1) Bamboo, 2) A substance for reacting with bamboo (water / aqueous agent), and 3) Ethyl Alcohol. The synthesis process involves two main steps: reacting the bamboo with the water-based agent, followed by reacting the resulting substance with Ethyl Alcohol.
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Description

Synthesis Method of Tetracycline from Bamboo

[0001] Chemistry , Biology , Medicine , Pharmacy

[0002] Tetracycline is an antibiotic used to treat several types of infections, such as acne, cholera, plague, and malaria, among others. Methods for producing Tetracycline can be performed in various ways. For example, Tetracycline can be obtained from Chlortetracycline through a Hydrogenation process using palladium as a catalyst (patent US2699054A). Natural bamboo does not contain Tetracycline as a constituent. The creation of Tetracycline from bamboo has never been discovered before.

[0003] The present invention relates to a composition, production method, or synthesis method for obtaining Tetracycline (Chemical formula C22H24N2O8) from bamboo.The raw materials consist of three types:

[0004] 1. Bamboo;

[0005] 2. A substance for reacting with bamboo (reaction agent) and;

[0006] 3. Ethyl Alcohol.

[0007] The production or synthesis method comprises two main steps:

[0008] 1. Synthesizing a substance from raw materials by reacting bamboo with the substance used to react with bamboo. Specifically, this involves preparing bamboo (such asThyrsostachyssiamensisGamble orThyrsostachysoliveriGamble), submerging it in the reaction agent (e.g., water, aqueous solution, or steam) for a period of 30 days, and then separating and air-drying the solid material.

[0009] 2. Reacting the substance obtained from step 1 with Ethyl Alcohol. This involves soaking the dried material in 99.9% Ethyl Alcohol for a period of 30 days to produce Tetracycline.

[0010] Conventionally, Tetracycline is produced through chemical synthesis methods, such as the hydrogenation of Chlortetracycline using palladium as a catalyst (as disclosed in patent US2699054A). These conventional methods may be complex, costly, or result in undesirable side effects. Furthermore, although bamboo is a natural resource, it does not naturally contain Tetracycline as a constituent , and there has been no prior known method to synthesize Tetracycline utilizing bamboo as a raw material. Therefore, there is a need for a novel method to synthesize Tetracycline from biological materials like bamboo to simplify production, reduce costs, and minimize side effects compared to traditional chemical synthesis

[0011] The present invention solves the aforementioned problem by providing a method for synthesizing Tetracycline from bamboo (specifically the genusThyrsostachysGamble). The method comprises the steps of preparing bamboo raw material, reacting said raw material with water or a water-based agent (submerging for 30 days), separating and air-drying the solids, and subsequently soaking the dried material in 99.9% Ethyl Alcohol for a period of 30 days to produce Tetracycline.

[0012] This invention utilizes bamboo as a raw material, which makes the creation of Tetracycline easier, reduces expenses, and reduces side effects and inflammation because it is produced via a biological method.

[0013] The method for creating or synthesizing Tetracycline comprises the following steps:

[0014] 1. Preparation of Raw Materials: The raw material utilized is bamboo, specifically from one or many of the following:

[0015] 1.1ThyrsostachyssiamensisGamble.

[0016] 1.2ThyrsostachysoliveriGamble.

[0017] 1.3 Any bamboo within the genusThyrsostachysGamble, including those currently classified, unclassified, unnamed, or to be named / classified in the future.

[0018] 1.4 Plants with botanical characteristics similar to or sharing the same genetic characteristics as the genusThyrsostachysGamble.

[0019] 1.5 Plant varieties or other biological cells resulting from breeding, genetic modification, or genetic transfer fromThyrsostachyssiamensisGamble,ThyrsostachysoliveriGamble, or the genusThyrsostachysGamble.

[0020] 1.6 Substances, chemical compositions, or organisms cultured or grown from a part of the genetics derived from the aforementioned bamboo.

[0021] 1.7 Plant varieties or other biological cells obtained from breedingThyrsostachyssiamensisGamble,ThyrsostachysoliveriGamble, or bamboo in the genusThyrsostachysGamble, or plants, substances, or other biological cells as described in items 1.1 – 1.6.

[0022] 1.8 Plant varieties or other biological cells resulting from genetic modification ofThyrsostachyssiamensisGamble,ThyrsostachysoliveriGamble, or bamboo in the genusThyrsostachysGamble, or plants, substances, or other biological cells as described in items 1.1 – 1.7.

[0023] 1.9 Any plant variety or other biological cell that has received genetics fromThyrsostachyssiamensisGamble,ThyrsostachysoliveriGamble, or bamboo in the genusThyrsostachysGamble, or plants, substances, or other biological cells as described in items 1.1 – 1.8.

[0024] 1.10 Substances, chemical compositions, or organisms that have been cultured or grown from a part of the genetics derived fromThyrsostachyssiamensisGamble,ThyrsostachysoliveriGamble, or bamboo in the genusThyrsostachysGamble, or substances, chemical compositions, or organisms cultured from the description in items 1.1 – 1.9.

[0025] 1.11 Part or all of the substances, chemical compositions, or organisms from the description in items 1.1 – 1.10.

[0026] 2. If the raw material exceeds 50 cm in length, it is cut into 50 cm in length and split into 4 pieces.

[0027] 3. Preparation of Reaction Agent: The agent reacting with the bamboo is prepared from one or many of the following:

[0028] 3.1 Pure water or distilled water.

[0029] 3.2 Aqueous solutions or mixtures containing water (e.g., canal water, sea water, tap water).

[0030] 3.3 Steam water.

[0031] 3.4 Substances that react to release or dissociate into water or steam.

[0032] 3.5 Substances that provide water or steam.

[0033] 4. Soaking Process: The prepared raw material (from 1. and 2.) is submerged in the reaction agent (from step 3.) for a period of 30 days.

[0034] 5. Separate only the solids for further use.

[0035] 6. Drying: the separated solids are air-dried.

[0036] 7. Alcohol Soaking: The dried material is then soaked in 99.9% Ethyl Alcohol for a period of 30 days.

[0037] 8. Result: Upon completion, Tetracycline is produced.

[0038] The invention can be utilized in the pharmaceutical and medical industries for the production of antibiotics.Patent Literature

[0039] US2699054A

Claims

A method of synthesizing Tetracycline (C22H24N2O8) from bamboo comprising the following steps:1.1 Preparing raw material by using any one of the following materials:1.1.1ThyrsostachyssiamensisGamble1.1.2ThyrsostachysoliveriGamble1.1.3 All bamboo in the genusThyrsostachysGamble, whether appearing in any current classification system, unclassified, unnamed, or named and / or classified after the filing date of the patent application.1.1.4 Bamboo in the genusThyrsostachysGamble that is named and / or classified after the filing date of the patent application.1.1.5 Every type of plant with botanical characteristics similar to bamboo in the genusThyrsostachysGamble.1.1.6 Plants having the same genetic characteristics as bamboo in the genusThyrsostachysGamble.1.1.7 Plant varieties or other biological cells obtained from breedingThyrsostachyssiamensisGamble orThyrsostachysoliveriGamble or bamboo in the genusThyrsostachysGamble, or plants or substances or other biological cells according to the description in 1.1.1 – 1.1.6.1.1.8 Plant varieties or other biological cells resulting from genetic modification ofThyrsostachyssiamensisGamble orThyrsostachysoliveriGamble or bamboo in the genusThyrsostachysGamble, or plants or substances or other biological cells according to the description in 1.1.1 – 1.1.7.1.1.9 Any plant variety or other biological cell that has received genetics fromThyrsostachyssiamensisGamble orThyrsostachysoliveriGamble or bamboo in the genusThyrsostachysGamble, or plants or substances or other biological cells according to the description in 1.1.1 – 1.1.8.1.1.10 Substances, chemical compositions, or organisms cultured or grown from a part of the genetics derivedfromThyrsostachyssiamensisGamble orThyrsostachysoliveriGamble or bamboo in the genusThyrsostachysGamble, or substances or chemical compositions or organisms cultured from the description in 1.1.1 – 1.1.9.1.1.11 Part or all of the substances, chemical compositions, or organisms from the description in 1.1.1 – 1.1.10.1.2 If the raw material obtained from 1.1 is longer than 50 cm, take the raw material from 1.1 and cut it into sections of 50 cm in length and split into 4 pieces.1.3 Preparing a substance to react with the bamboo from any one of the following substances:1.3.1 Pure water or distilled water.1.3.2 Solutions containing water as a constituent or mixture, such as canal water, sea water, tap water.1.3.3 Steam Water.1.3.4 Substances that react or react with other substances to provide or dissociate to provide water or steam.1.3.5 Substances that provide water or steam.1.4 Taking the raw material obtained from 1.1 and soaking it submerged in the substance from 1.3 for a period of 30 days.1.5 From 1.4, separating only the solids for further use.1.6 Taking the raw material obtained from 1.5 and air drying.1.7 Taking the raw material obtained from 1.6 and soaking in Ethyl Alcohol 99.9% for a period of 30 days.1.8 Tetracycline will be found to have been produced.