Biological reaction device, assembly, and operating method

By designing a bioreactor that utilizes a rotating plate and a hollow shaft to transport fluid, the problem of generating uniform cell aggregates in existing cell cultures has been solved, enabling efficient and reliable large-scale production of cell aggregates to meet clinical needs.

WO2026149496A1PCT designated stage Publication Date: 2026-07-16OXFORD UNIV (SUZHOU) SCI & TECH CO LTD
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Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
OXFORD UNIV (SUZHOU) SCI & TECH CO LTD
Filing Date
2026-01-08
Publication Date
2026-07-16

AI Technical Summary

Technical Problem

Existing cell culture technologies struggle to generate uniform cell aggregates, diffusion conditions limit the delivery of oxygen and nutrients, and make it difficult to achieve large-scale production and high-purity cell products.

Method used

Design a bioreactor comprising a container, a plate, and a hollow shaft, through which fluid is delivered via openings in the rotating plate and shaft, and combined with disposable consumable components and automated cell culture components to achieve efficient fluid circulation and cell aggregate production.

Benefits of technology

It achieves highly reproducible and reliable cell aggregate generation, improves the controllability and scalability of biological reactions, meets the needs of large-scale clinical production, and the generated cell aggregates have high homogeneity and high survival rate.

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Abstract

A biological reaction device, an assembly and an operating method. The device comprises: a container, which creates a sealed accommodating space and is provided with at least two fluid ports, the fluid ports being in communication with the accommodating space; at least one plate, which is a flat plate or a microwell plate and which is arranged in parallel in the accommodating space; and a shaft, which is connected to at least one end of the container and passes through each plate, wherein the plate rotates as the shaft or the container rotates, the shaft is of a hollow structure and is provided with an opening for delivering a fluid in the shaft to each plate. The above technical solution is particularly suitable for the culturing of cells and spheroids, and can be used for mass production on the basis of the number and sizes of cell aggregates, thereby producing products having high repeatability, reliability, homogeneity and uniform size, improving the controllability, scalability, safety and compliance of biological reactions, improving the level of automated production, and meeting large-scale clinical production requirements.
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