Fluid mixer unit device for nanoparticle production

The microplate device with fluid mixing units addresses the limitations of current lipid nanoparticle production by enabling high-throughput and cost-effective screening, optimizing geometric shapes for improved mRNA delivery systems.

JP2026521669APending Publication Date: 2026-07-01ASTRAZENECA AB
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
ASTRAZENECA AB
Filing Date
2024-04-04
Publication Date
2026-07-01

AI Technical Summary

Technical Problem

Current methods for producing lipid nanoparticles for mRNA delivery face limitations due to high costs and low throughput, primarily associated with commercially available platforms and screening tests, which hinder the identification of efficient delivery vehicles.

Method used

A device comprising a microplate with an array of fluid mixing units, each with unique flow paths, allows for simultaneous production and evaluation of lipid nanoparticles, enabling high-throughput screening and optimization of geometric shapes for improved delivery systems.

Benefits of technology

Enables the miniaturized, cost-effective, and high-throughput production of lipid nanoparticles, facilitating the systematic testing and development of novel formulations that meet industrial standards for mRNA therapeutic delivery.

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Abstract

The device 100 for producing nanoparticles includes a microplate 102 containing multiple fluid mixing units 104 arranged in an array. Each fluid mixing unit is configured to produce nanoparticles. The device is configured to enable high-throughput lipid nanoparticle testing and development and to generate a large number of novel or specific nanoparticle formulations.
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