Dragonrna: DNA-primed RNA-extension activities by DNA-directed RNA

DragonRNA, a 5'-DNA-capped RNA molecule synthesized using DNA-dependent RNA polymerases, addresses the challenge of RNA degradation by enhancing stability and enabling stable RNA-based applications.

WO2026156187A2PCT designated stage Publication Date: 2026-07-23THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Filing Date
2026-01-15
Publication Date
2026-07-23

AI Technical Summary

Technical Problem

The natural degradation of RNA in cells and organisms limits its utility in genetic, immunological, and therapeutic applications, necessitating improved methods for enhancing RNA stability and preservation.

Method used

The synthesis of DragonRNA, a 5'-DNA-capped RNA molecule, which utilizes DNA sequences as primers and templates for RNA extension, providing enhanced stability and protection from hydrolysis through the use of DNA-dependent RNA polymerases.

Benefits of technology

DragonRNA exhibits increased stability and persistence, allowing for effective RNA-based medical applications and biological research by templating RNA sequences based on DNA input, offering protection against degradation.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure IMGF000043_0001
    Figure IMGF000043_0001
  • Figure IMGF000050_0001
    Figure IMGF000050_0001
  • Figure 00000060_0000
    Figure 00000060_0000
Patent Text Reader

Abstract

Compositions and methods are provided for the synthesis of RNA capped with DNA at the 5' end, herein termed "DragonRNA". In some embodiments the capped RNA is protected from hydrolysis, thereby enhancing RNA in-solution and enzymatic stability. This RNA synthesis platform enhances RNA stability and provides a solution for preserving RNAs.
Need to check novelty before this filing date? Find Prior Art