Autologous blood reinfusion system and method
Patent Information
- Application Number
- PCT/CN2025/078619
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2025-02-21
- Publication Date
- 2026-08-27
Smart Images
Figure CN2025078619_27082026_PF_FP_ABST
Abstract
Description
An autologous blood reinfusion system and method Technical Field
[0001] This application relates to the field of medical device technology, and in particular to an autologous blood reinfusion system and method. Background Technology
[0002] Autologous blood transfusion systems are used to collect and store blood lost by patients during surgery, and then return the stored blood to the patient after filtration to prevent further blood loss and avoid the risk of infectious diseases caused by allogeneic blood transfusions. Summary of the Invention
[0003] This application discloses an autologous blood reinfusion system, comprising a collection module, a storage module, an output module, and a control module. The collection module collects blood from a target object and transmits the blood to the storage module. The storage module stores the blood, acquires the blood level height value, and sends the blood level height value to the control module. The output module includes a first power unit, a filtration unit, and a first pressure monitoring unit connected in sequence. The first power unit is connected to the storage module. The first power unit has a start mode and a stop mode. In the start mode, the first power unit delivers the blood from the storage module to the filtration unit. The first power unit is used to filter blood and deliver the filtered blood to the target object; the first pressure monitoring unit is used to acquire a first pressure value of the filtering unit and send it to the control module; the control module is used to compare the blood level height value with a first threshold, and if the blood level height value is less than the first threshold, send a stop signal to the first power unit; the control module is used to compare the first pressure value with a second threshold, and if the first pressure value is greater than the second threshold, send a stop signal to the first power unit; the stop signal is used to control the first power unit to switch from the start mode to the stop mode to stop delivering the filtered blood to the target object.
[0004] This application also discloses an autologous blood reinfusion method, which is applied to the autologous blood reinfusion system described in any of the above embodiments; the method includes:
[0005] The first power unit is controlled to be in start-up mode;
[0006] Obtain the initial pressure value and blood level value;
[0007] Compare the blood level height value with a first threshold. If the blood level height value is less than the first threshold, send a stop signal to the first power unit.
[0008] By comparing the first pressure value with the second threshold, if the first pressure value is greater than the second threshold, a stop signal is sent to the first power unit. Attached Figure Description
[0009] Figure 1 is a schematic diagram of an autologous blood reinfusion system provided in an embodiment of this application;
[0010] Figure 2 is a schematic diagram of an autologous blood reinfusion system provided in an embodiment of this application;
[0011] Figure 3 is a schematic diagram of the structure of a storage module provided in an embodiment of this application;
[0012] Figure 4 is a schematic diagram of the structure of a data acquisition module provided in an embodiment of this application;
[0013] Figure 5 is a schematic diagram of the structure of a suction head provided in an embodiment of this application;
[0014] Figure 6 is a schematic diagram of the structure of an suction head provided in an embodiment of this application;
[0015] Figure 7 is a schematic diagram of an autologous blood reinfusion system provided in an embodiment of this application;
[0016] Figure 8 is a schematic diagram of the structure of a heating unit provided in an embodiment of this application;
[0017] Figure 9 is a schematic diagram of the structure of an output module provided in an embodiment of this application;
[0018] Figure 10 is a schematic diagram of the structure of an autologous blood reinfusion system provided in an embodiment of this application;
[0019] Figure 11 is a schematic flowchart of an autologous blood reinfusion method provided in an embodiment of this application. Detailed Implementation
[0020] To facilitate understanding of the various aspects, features, and advantages of the technical solution of this application, the application will be described in detail below with reference to the accompanying drawings. It should be understood that the various embodiments described below are for illustrative purposes only and are not intended to limit the scope of protection of this application.
[0021] In the description of this application, it should be noted that throughout the specification and claims, the term "coupled" is defined as a direct or indirect connection in an electrical or non-electrical manner. When an element is described as "connected" or "coupled" to another element, it may be directly connected or coupled to the other element, or one or more intermediate elements may be present. Conversely, when an element is described as "directly connected" or "directly coupled" to another element, no intermediate elements are present. Throughout the specification, references to "an embodiment," "an example," or "example" mean that a particular feature, structure, or characteristic described in connection with that embodiment or example is included in at least one embodiment of this application. Therefore, the phrases "in an embodiment," "in an embodiment," "an example," or "example" appearing in various places throughout the specification do not necessarily refer to the same embodiment or example. Furthermore, specific features, structures, or characteristics may be combined in one or more embodiments or examples in any suitable combination and / or sub-combination. Moreover, those skilled in the art should understand that the accompanying drawings provided herein are for illustrative purposes and are not necessarily drawn to scale. The same reference numerals indicate the same devices. The term “and / or” as used herein includes any and all combinations of one or more of the related listed items.
[0022] The applicant has conducted research on autologous blood transfusion systems. The applicant found that autologous blood transfusion systems lack monitoring and control devices; therefore, abnormalities during the blood transfusion process cannot be detected in a timely manner, nor can the autologous blood transfusion system be controlled when abnormalities occur.
[0023] This application provides an autologous blood reinfusion system and method, which can achieve at least the following technical effects: it enables timely reinfusion of autologous blood, avoiding blood loss; compared to allogeneic blood transfusion, it reduces adverse reactions and the risk of infectious disease transmission; and it maintains hemodynamic stability even during significant intraoperative blood loss. Furthermore, this application can promptly detect abnormalities such as insufficient blood storage or blockages in the transfusion pathway, and stop the transfusion when abnormalities occur, reducing intraoperative risks.
[0024] Referring to Figure 1, this application proposes an autologous blood reinfusion system. The system includes a collection module 1, a storage module 2, an output module 3, and a control module 4. The collection module 1 collects blood from a target object 5 and transmits the blood to the storage module 2. The storage module 2 stores the blood, obtains the blood level height value, and sends the blood level height value to the control module 4. The output module 3 includes a first power unit 31, a filtration unit 32, and a first pressure monitoring unit 33 connected in sequence. The first power unit 31 is connected to the storage module 2. The first power unit 31 has a start mode and a stop mode. In the start mode, the first power unit 31 delivers the blood from the storage module 2 to the filtration unit 32, and... The filtration unit 32 filters the blood to remove air bubbles and impurities, and delivers the filtered blood to the target object 5. The first pressure monitoring unit 33 acquires the first pressure value of the filtration unit 32 and sends it to the control module 4. The control module 4 compares the blood level height with a first threshold, and sends a stop signal to the first power unit 31 if the blood level height is less than the first threshold. The control module 4 also compares the first pressure value with a second threshold, and sends a stop signal to the first power unit 31 if the first pressure value is greater than the second threshold. The stop signal controls the first power unit 31 to switch from the start mode to the stop mode to stop delivering the filtered blood to the target object 5. The target object 5 is a patient undergoing surgery. The acquisition module 1 collects the lost blood from the surgical field of the target object 5, and the output module 3 delivers the filtered blood to the blood vessels of the target object 5.
[0025] Specifically, the first threshold can be set to 2cm, 3cm, etc., and the second threshold can be set to 60mmhg, 65mmhg, 70mmhg, etc.
[0026] Specifically, the first power unit 31 can be a roller pump, the first pressure monitoring unit 33 can be a pressure gauge, and the filtration unit 32 can be a micro-plug filter.
[0027] If the blood level is less than the first threshold, it means that the amount of blood stored in the storage module 2 is insufficient. Therefore, the first power unit 31 needs to be switched to the stop mode in time to stop the blood transfusion to the target object 5, prevent air in the storage module 2 from entering the blood vessels of the target object 5, and reduce the surgical risk.
[0028] If the first pressure value is greater than the second threshold, it indicates that there is a blockage in the autologous blood reinfusion system, and the blood cannot be smoothly reinfused to the target object 5. Therefore, it is necessary to switch the first power unit 31 to the stop mode in time to stop the blood transfusion to the target object 5.
[0029] In some embodiments, the control module 4 also has a display function. When the first pressure value is greater than the second threshold, and / or when the blood level is less than the first threshold, the control module 4 can display corresponding alarm information to remind medical personnel to check the location of the blockage in time, or to remind medical personnel to transfuse foreign blood to make up for the lack of autologous blood.
[0030] Based on the above embodiments, this application enables timely reinfusion of autologous blood, avoiding loss of autologous blood. Compared to allogeneic blood transfusion, it reduces adverse reactions and the risk of infectious disease transmission, and maintains hemodynamic stability even with significant intraoperative blood loss. Furthermore, the reinfused blood in this application is whole blood, including red blood cells, platelets, clotting factors, albumin, and other components. Compared to methods that only reinfuse red blood cells, this significantly reduces the need for non-red blood cell allogeneic blood products, protects the body's own coagulation function, mitigates damage to coagulation function, lung function, and kidney function caused by surgery, and lowers surgical costs. Furthermore, this application can promptly detect abnormalities such as insufficient blood storage and blockages in the transfusion pathway, and stop transfusion when abnormalities occur, reducing intraoperative risks.
[0031] In some embodiments, referring to FIG2, the storage module 2 includes a first container 21 and a liquid level monitoring unit 22; the first container 21 is connected to the acquisition module 1 and the first power unit 31, and is used to store blood; the liquid level monitoring unit 22 is used to acquire the blood liquid level height value in the first container 21 and send it to the control module 4. The control module 4 is communicatively connected to the first power unit 31, the liquid level monitoring unit 22, and the first pressure monitoring unit 33.
[0032] In some embodiments, the first container 21 may be a medical blood storage tank. The liquid level monitoring unit 22 may be an ultrasonic liquid level gauge.
[0033] In some embodiments, referring to FIG3, the storage module 2 further includes a second container 23 connected to the first container 21; the second container 23 is used to store an anticoagulant and deliver the anticoagulant to the first container 21. The anticoagulant is used to prevent blood clotting in the first container 21.
[0034] In some embodiments, as shown in FIG10, a filter membrane 211 is provided inside the first container 21. After the blood from the collection module 1 passes through the filter membrane 211, it is stored at the bottom of the first container 21. The filter membrane 211 is used to filter the blood and initially remove impurities and air bubbles from the blood.
[0035] In some embodiments, referring to FIG4, the acquisition module 1 includes a suction tube 11, a second pressure monitoring unit 12, and a second power unit 13; the suction tube 11 is connected to the second power unit 13 and the second pressure monitoring unit 12 respectively; the second power unit 13 is connected to the storage module 2; the second pressure monitoring unit 12 and the second power unit 13 are communicatively connected to the control module 4; the second power unit 13 has a start mode and a stop mode; in the start mode, the second power unit 13 is used to collect blood from the target object 5 through the suction tube 11 and transmit the blood to the storage module 2; the second pressure monitoring unit 12 is used to obtain a second pressure value of the suction tube 11 and send it to the control module 4; the control module 4 is used to compare the second pressure value with a third threshold, and if the second pressure value is greater than the third threshold, send a stop signal to the second power unit 13; the stop signal is used to control the second power unit 13 to switch from the start mode to the stop mode to stop collecting blood from the target object 5.
[0036] Specifically, the second pressure monitoring unit 12 can be a pressure gauge, and the second power unit 13 can be a roller pump. The second power unit 13 is connected to the first container 21 (not shown in Figure 4) in the storage module 2.
[0037] Specifically, the third threshold can be set to -70 mmHg. If the second pressure value is greater than the third threshold, it indicates that the blood pressure in the suction line 11 is too high, which may cause blood cells in the blood to rupture and affect the blood transfusion effect.
[0038] Based on the above embodiments, blood collection from the target object 5 is stopped when the second pressure value is greater than the third threshold, which can avoid collecting unqualified blood under excessive pressure conditions and prevent the cells and effective components in the blood from being destroyed.
[0039] In some embodiments, referring to Figures 4, 5, and 6, a suction head 111 is provided at the end of the suction tube 11 away from the second power unit 13. The suction head 111 has a hollow structure and multiple suction holes 112 penetrating its surface. The suction holes 112 may be elliptical. The second power unit 13 provides power, and blood enters the suction tube 11 through the suction holes 112 and is transported to the storage module 2 through the suction tube 11. The suction head 111 can suction blood with a relatively small negative pressure, reducing damage to blood cells.
[0040] In some embodiments, referring to FIG7, the output module 3 further includes a heating unit 34; the heating unit 34 is connected to the first power unit 31 and the filtration unit 32, and is used to heat the blood. Correspondingly, the filtration unit 32 is used to filter the heated blood.
[0041] In some embodiments, referring to FIG8, the heating unit 34 includes a heat exchange tube 341 and a heat exchange water tank 342. The heat exchange tube 341 is connected to the first power unit 31 and the filter unit 32, and is used to transport blood and increase heat exchange efficiency. The heat exchange water tank 342 is used to heat the heat exchange tube 341 in a water bath. Specifically, the heat exchange water tank 342 stores water, and the heat exchange tube 341 can be placed in the water. The heat exchange water tank 342 heats the heat exchange tube 341 in a water bath, thereby heating the blood as it passes through the heat exchange tube 341. Delivering the heated blood to the target subject 5 can avoid the risk of hypothermia during surgery and help maintain the normal body temperature of the target subject 5. The two ends of the heat exchange tube 341 have openings, which are respectively connected to the filter unit 32 and the first power unit 31. The heat exchange tube 341 has a larger diameter, which increases the contact area between the heat exchange tube 341 and water, and the contact area between blood and the heat exchange tube 341. Therefore, the heat exchange efficiency can be increased, and blood can be heated in a shorter time, achieving a more efficient blood heating effect.
[0042] In some embodiments, referring to FIG9, the output module 3 further includes a first infusion line 35, which includes a first port 351, a second port 352, a third port 353, and a tubing clamp 354. The first port 351 is connected to the storage module 2, the second port 352 is connected to the first power unit 31, and the third port 353 is connected to an external medical system. The tubing clamp 354 is disposed between the second port 352 and the third port 353. When the tubing clamp 354 is closed, the first infusion line 35 is used to deliver blood from the storage module 2 to the external medical system for blood supply to the medical system, which may be an on-pump cardiac surgery system. When the tubing clamp 354 is open, the first power unit 31 is used to deliver blood from the storage module 2 to the filtration unit 32.
[0043] In some embodiments, referring to FIG9, the first infusion line 35 further includes a T-connector 355, which is disposed between the second port 352 and the tubing clamp 354. When the tubing clamp 354 is closed, the first infusion line 35 obtains the target drug solution through the T-connector 355. The first power unit 31 is used to deliver the target drug solution to the target object 5. The T-connector 355 has three ports, two of which are connected to the first port 351 and the second port 352 respectively, and the other port is used to receive the target drug solution (e.g., cardioplegic solution). When the tubing clamp 354 is closed, the blood transfusion is stopped, and the first power unit 31 is used to deliver the target drug solution to the target object 5. When the tubing clamp 354 is open, the target drug solution can also be received from the T-connector 355, and the first power unit 31 is used to deliver the mixture of blood and target drug solution to the filter unit 32 and then to the target object 5.
[0044] In some embodiments, the liquid level monitoring unit 22 may further include a densitometer. The densitometer is communicatively connected to the control module 4 and is used to acquire the density value of the blood in the first container 21 and send the density value to the control module 4. The control module 4 compares the density value with a fourth threshold. If the density value is less than the fourth threshold, it indicates that a large amount of air has mixed in with the blood, and it cannot be input to the target object 5. The control module 4 then sends a stop signal to the first pressure monitoring unit 33.
[0045] In some embodiments, referring to FIG10, this application proposes a specific autologous blood reinfusion system. A second power unit 13 is in activation mode to provide power. A suction head 111 absorbs lost blood from the surgical field of the target patient 5. The blood passes through a suction line 11 and a second infusion line 36, and is then introduced into a first container 21 for storage. A second container 23 stores an anticoagulant, which can enter the first container 21 from the second container 23 to prevent blood clotting. A filter membrane 211 is provided inside the first container 21 to perform a first filtration of the blood to remove air bubbles and impurities. The first power unit 31 is in start-up mode to provide power. Blood enters the heat exchange tube 341 through the first infusion tube 35 and the second infusion tube 36. The heat exchange water tank 342 heats the heat exchange tube 341 in a water bath, thereby raising the temperature of the blood passing through the heat exchange tube 341. The heated blood then enters the filtration unit 32 through the second infusion tube 36 for a second filtration. The filtered blood then enters the blood vessels of the target object 5 through the second infusion tube 36 and the Luer connector 37 to achieve autologous blood reinfusion. The control module 4 is communicatively connected to the first power unit 31, the second power unit 13, the liquid level monitoring unit 22, the first pressure monitoring unit 33, and the second pressure monitoring unit 12. The first pressure monitoring unit 33 is used to acquire the first pressure value of the filtration unit 32 and send it to the control module 4. The control module 4 compares the first pressure value with a second threshold. If the first pressure value is greater than the second threshold, it sends a stop signal to the first power unit 31. The stop signal is used to control the first power unit 31 to switch from start-up mode to stop the delivery of filtered blood to the target object 5. A liquid level monitoring unit 22 can be installed inside the first container 21 to acquire the blood level height value in the first container 21 and send it to the control module 4. The control module 4 compares the blood level height value with a first threshold, and sends a stop signal to the first power unit 31 if the blood level height value is less than the first threshold. A second pressure monitoring unit 12 acquires the second pressure value of the suction tube 11 and sends it to the control module 4. The control module 4 compares the second pressure value with a third threshold, and sends a stop signal to the second power unit 13 if the second pressure value is greater than the third threshold. The stop signal controls the second power unit 13 to switch from the start mode to the stop mode to stop collecting blood from the target object 5. A first infusion tube 35 connects the first container 21 and the first power unit 31. The first infusion tube 35 has a first port 351, a second port 352, a third port 353, a tube clamp 354, and a tee connector 355.A third port 353, a pipe clamp 354, and a tee connector 355 are arranged between the first port 351 and the second port 352. The third port 353 is located closer to the first port 351, the tee connector 355 is located closer to the first power unit 31, and the pipe clamp 354 is located between the third port 353 and the tee connector 355. The first port 351 is connected to the first container 21, the second port 352 is connected to the first power unit 31, and the third port 353 is connected to an external medical system. When the pipe clamp 354 on the first infusion line 35 is closed, the blood transfusion stops, and the blood in the first container 21 cannot enter the heat exchange tube 341. The blood can enter the medical system through the third port 353 to supply blood to the medical system. When the pipe clamp 354 on the first infusion line 35 is closed, the blood transfusion stops, and the target drug solution can be obtained through the tee connector 355 on the first infusion line 35. The first power unit 31 is used to deliver the target drug solution to the target object 5. The filter unit 32 and the target object 5 are connected via a second transfusion line 36, which has a tubing clamp 354 and a Luer connector 37. The Luer connector 37 can be connected to the target object 5 or to another tee connector. The tubing clamp 354 in the second transfusion line 36 is used to control whether to terminate the transfusion; when closed, the transfusion is terminated, and when open, the transfusion continues normally.
[0046] This application proposes an autologous blood reinfusion method, as shown in Figure 11. The method is applied to the autologous blood reinfusion system described in any embodiment, and the method includes:
[0047] S101: Controls the first power unit to be in start-up mode;
[0048] S102: Obtain the first pressure value and blood level height value;
[0049] S103: Compare the blood level height value with the first threshold. If the blood level height value is less than the first threshold, send a stop signal to the first power unit.
[0050] S104: Compare the first pressure value with the second threshold. If the first pressure value is greater than the second threshold, send a stop signal to the first power unit.
[0051] It should be noted that the above method may include other implementation methods according to the description of the system embodiments. For specific implementation methods, please refer to the description of the relevant system embodiments, which will not be elaborated here.
[0052] Those skilled in the art should understand that the above-disclosed embodiments are merely implementations of this application and should not be construed as limiting the scope of the patent protection claimed in this application. Equivalent variations made according to the implementations of this application shall still fall within the scope of the claims of this application.
Claims
1. An autologous blood reinfusion system, wherein, The system includes a data acquisition module, a storage module, an output module, and a control module; The acquisition module is used to collect blood from the target object and transmit the blood to the storage module; The storage module is used to store blood, obtain the blood level height value, and send the blood level height value to the control module; The output module includes a first power unit, a filter unit, and a first pressure monitoring unit connected in sequence; the first power unit is connected to the storage module. The first power unit has a start mode and a stop mode; in the start mode, the first power unit is used to deliver blood from the storage module to the filtration unit, the filtration unit is used to filter the blood, and deliver the filtered blood to the target object; The first pressure monitoring unit is used to acquire the first pressure value of the filter unit and send it to the control module; The control module is used to compare the blood level height value with a first threshold, and send a stop signal to the first power unit when the blood level height value is less than the first threshold. The control module is used to compare the first pressure value with the second threshold. If the first pressure value is greater than the second threshold, a stop signal is sent to the first power unit. The stop signal is used to control the first power unit to switch from the start mode to the stop mode, so as to stop delivering filtered blood to the target object.
2. The system according to claim 1, wherein, The storage module includes a first container and a liquid level monitoring unit; the first container is connected to the acquisition module and the first power unit and is used to store blood; the liquid level monitoring unit is used to acquire the blood level height value in the first container and send it to the control module.
3. The system according to claim 2, wherein, The control module is communicatively connected to the first power unit, the liquid level monitoring unit, and the first pressure monitoring unit.
4. The system according to claim 2, wherein, The storage module further includes a second container connected to the first container; the second container is used to store anticoagulants and deliver anticoagulants to the first container.
5. The system according to claim 2, wherein, The first container is equipped with a filter membrane, which is used to filter blood.
6. The system according to claim 1, wherein, The acquisition module includes a suction pipe, a second pressure monitoring unit, and a second power unit; the suction pipe is connected to the second power unit and the second pressure monitoring unit respectively; the second power unit is connected to the storage module; the second pressure monitoring unit and the second power unit are communicatively connected to the control module. The second power unit has a start mode and a stop mode; in the start mode, the second power unit is used to collect blood from the target object through the suction tube and transfer the blood to the storage module; The second pressure monitoring unit is used to acquire the second pressure value of the suction line and send it to the control module; The control module is used to compare the second pressure value with the third threshold. If the second pressure value is greater than the third threshold, a stop signal is sent to the second power unit. The stop signal is used to control the second power unit to switch from the start mode to the stop mode to stop collecting blood from the target object.
7. The system according to claim 6, wherein, The suction pipe is provided with a suction head at one end away from the second power unit. The suction head has a hollow structure and multiple suction holes that penetrate its surface.
8. The system according to claim 1, wherein, The output module further includes a heating unit; the heating unit is connected to the first power unit and the filtration unit, and is used to heat the blood.
9. The system according to claim 8, wherein, The heating unit includes heat exchange tubes and a heat exchange water tank; The heat exchange tube is connected to the first power unit and the filter unit, and is used to transfer blood and increase heat exchange efficiency; the heat exchange water tank is used to heat the heat exchange tube in a water bath.
10. The system according to claim 1, wherein, The output module further includes a first infusion line, which includes a first port, a second port, a third port, and a tubing clamp. The first port is connected to the storage module, the second port is connected to the first power unit, and the third port is connected to an external medical system; The pipe clamp is installed between the second port and the third port; When the tubing clamp is closed, the first transfusion tubing is used to deliver blood from the storage module to an external medical system.
11. The system according to claim 10, wherein, The first infusion line also includes a T-connector, which is disposed between the second port and the pipeline clamp; When the pipeline clamp is closed, the first infusion pipeline obtains the target drug solution through the three-way connector; The first power unit is used to deliver the target drug solution to the target object.
12. A method for autologous blood reinfusion, wherein, The method is applied to the autologous blood reinfusion system as described in any one of claims 1 to 11, the method comprising: The first power unit is controlled to be in start-up mode; Obtain the initial pressure value and blood level value; Compare the blood level height value with a first threshold. If the blood level height value is less than the first threshold, send a stop signal to the first power unit. By comparing the first pressure value with the second threshold, if the first pressure value is greater than the second threshold, a stop signal is sent to the first power unit.