Methods of treating vascular diseases
Administering hemogenic endothelial cells derived from pluripotent stem cells addresses the inadequacies of current treatments for vascular diseases by reducing blood pressure and improving blood flow, providing a promising therapeutic option for conditions like pulmonary hypertension.
AU2020337929B2Pending Publication Date: 2026-07-16ADVANCED CELL TECH INC
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Patent Information
- Application Number
- AU2020337929
- Authority / Receiving Office
- AU · AU
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2019-08-28
- Filing Date
- 2020-08-27
- Publication Date
- 2026-07-16
AI Technical Summary
Technical Problem
Current treatments for cardiovascular diseases such as pulmonary hypertension, coronary artery disease, and peripheral arterial disease are inadequate in preventing pathogenic remodeling and often have significant side effects, with no effective treatment for critical limb ischemia.
Method used
Administering a composition of hemogenic endothelial cells (HEs) derived from in vitro differentiation of pluripotent stem cells to treat vascular diseases, which can reduce mean pulmonary pressure, increase blood flow, and lower blood pressure.
Benefits of technology
The method effectively reduces blood pressure and improves blood flow in pulmonary arteries, offering a potential treatment for pulmonary hypertension and other vascular diseases with minimal side effects.
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Abstract
The present invention provides methods for treating vascular diseases with hemogenic endothelial cells (HEs) obtained in vitro from pluripotent stem cells. The present invention also provides compositions and methods of producing the HEs.
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