HIDROXIÁCIDOS PARA COURO CABELUDO E CABELO EM COMPOSIÇÕES PARA CUIDADOS PESSOAIS

Abstract

A personal care composition comprising from 2% to 10% of an anionic surfactant; from 0.5% to 5% of a hydroxy acid selected from the group consisting of salicylic acid in combination with citric acid; wherein the personal cleansing composition has a pH of about 2.5 to about 5.5.

Description

1 / 97 Hydroxy acids for scalp and hair in personal care compositions. FIELD OF THE INVENTION

[0001] The present invention relates to hydroxy acids for scalp and facial / body skin, hair in personal care compositions that can provide benefits to the scalp and facial / body skin and hair. BACKGROUND OF THE INVENTION

[0002] Hydroxy acids are a class of materials that have been commonly used in the skincare industry to improve skin health through chemical exfoliation and oil control. Typically, these ingredients are highly water-soluble and often applied via a topical lotion or ointment that is left on the skin after use, ensuring the application of the ingredients to the target treatment areas. In the hair and scalp and facial / body skin cleansing space, rinse-off bath treatments containing surfactants (i.e., shampoos, cleansing washes, and intimate washes) are far more common ways of applying beneficial ingredients to hair, scalp, and facial / body skin. Therefore, there is a need for the invention of a rinse-off cleansing product that can effectively apply hydroxy acid actives to hair, scalp, and facial / body skin. SUMMARY OF THE INVENTION

[0003] The present invention relates to a personal care composition comprising from 2% to 10% of a Petition 870250079886, dated 05 / 09 / 2025, page 7 / 204 2 / 97 anionic surfactant; from 0.5% to 5% of a hydroxy acid selected from the group consisting of salicylic acid in combination with citric acid; wherein the personal hygiene composition has a pH of about 2.5 to about 5.5. DETAILED DESCRIPTION OF THE INVENTION EMBODIMENTS

[0004] All percentages and ratios used herein are expressed by weight of the total composition, except where otherwise indicated. All measurements are understood to be made under ambient conditions, the term ambient conditions meaning conditions at approximately 25 °C, under approximately one atmosphere of pressure and approximately % relative humidity, except where otherwise indicated. All numerical ranges include narrower ranges; the upper and lower range limits delineated are combinable to create additional ranges not explicitly delineated.

[0005] The compositions of the present invention may comprise, consist essentially of, or consist of essential ingredients, as well as optional ingredients described herein. As used herein, the expression "consist essentially of" means that the composition or component may include additional ingredients, but only if these do not substantially alter the basic and innovative characteristics of the compositions or methods claimed.

[0006] To apply or application, as used in reference to a composition, means to apply or spread the Petition 870250079886, dated 05 / 09 / 2025, page 8 / 204 3 / 97 compositions of the present invention on a keratinous tissue such as hair.

[0007] Dermatologically acceptable means that the compositions or components described are suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability or allergic response, and the like.

[0008] Safe and effective amount means an amount of a compound or composition sufficient to significantly induce a positive benefit.

[0009] Although the descriptive report ends with claims that specifically point out and distinctly claim the invention, it is believed that the present invention will be better understood from the following description.

[0010] As used herein, the term fluid includes liquids and gels.

[0011] As used herein, the indefinite articles a and an, when used in a claim, are understood to refer to one or more of the items claimed or described.

[0012] As used herein, to understand means that other steps and other ingredients that do not affect the final result may be added. This term encompasses the terms to consist of and to consist essentially of.

[0013] As used herein, the term mixtures is intended to include a unique combination of materials and any compounds that may result from that combination.

[0014] As used herein, molecular weight or PM refers to the weight-average molecular weight, except where otherwise specified. Molecular weight is measured Petition 870250079886, dated 05 / 09 / 2025, page 9 / 204 4 / 97 using the industry standard method, gel permeation chromatography (GPC).

[0015] When ranges of quantities are given, these should be understood as the total quantity of said ingredient in the composition or when more than one species is covered by the scope of the ingredient definition, the total quantity of all ingredients present in the composition corresponds to that definition.

[0016] For example, if the composition comprises 1% to 5% fatty alcohol, then a composition comprising % stearyl alcohol and 1% cetyl alcohol and no other fatty alcohol would be covered by the scope.

[0017] The quantity of each particular ingredient, or mixtures thereof, described herein, may account for up to 100% (or 100%) of the total quantity of the ingredient(s) in the personal care composition.

[0018] As used herein, personal care compositions include products such as shampoos, shower gels, liquid hand cleaners, hair dyes, facial cleansers, liquid shaving soaps, liquid intimate washes, and other liquid surfactant-based compositions intended for cleansing the scalp, hair, body, and skin.

[0019] As used herein, the terms include, includes and include are intended to be non-limiting and are understood to mean comprise, comprehend and comprehend, respectively. Petition 870250079886, dated 05 / 09 / 2025, p. 10 / 204 5 / 97

[0020] All percentages, parts and proportions are based on the total weight of the compositions of the present invention, except where otherwise specified. All such weights, insofar as they refer to the ingredients in the list, are based on the active content and therefore do not include carriers or by-products that may be included in commercially available materials.

[0021] Except where otherwise specified, all component or composition contents refer to the active portion of that component or composition and exclude impurities, for example, residual solvents or by-products, which may be present in commercially available sources of such components or compositions.

[0022] It should be understood that each maximum numerical limit presented throughout this descriptive report includes each of the lower numerical limits, as if such lower numerical limits were expressly written in the present invention. Each minimum numerical limit presented throughout the descriptive report includes each of the upper numerical limits, as if such upper numerical limits were expressly written in the present invention. Each numerical range shown in this descriptive report includes each narrower numerical range falling within such a wider numerical range, as if such narrower numerical ranges were expressly written in the present invention. Petition 870250079886, dated 05 / 09 / 2025, p. 11 / 204 6 / 97 A. Hydroxy acids

[0023] Alpha and beta hydroxy acids are a class of materials that have long been used in the cosmetics industry. Some hydroxy acids, such as citric acid, are known to be effective metal chelators. It is presumed that chelation of metals from hair, scalp, and body hair enables health benefits for hair, scalp, and skin by removing an accumulation of excess metals within and on the surface. Knowing this, the present invention screened several hydroxy acids for their ability to chelate calcium from a lipid matrix (i.e., scalp / facial skin and body / hair). Some hydroxy acids performed better than others in the screening studies.The hypothesis for this is twofold, based on the fact that some hydroxy acids have a higher driving force to penetrate a lipid matrix, as determined by the octanol-water partition coefficient (LogP for neutral species, LogD for charged elements), and some have a greater affinity for binding metals (LogKmetal).

[0024] The present invention has discovered that a mixture of hydroxy acids (salicylic and citric) is capable of chelating metals from hair, scalp, and facial and body skin. Salicylic acid is used for internal metal chelation while citric acid is used for surface-level chelation. The removal and binding of metals from both locations is important because it can enable a reduction in surface-level accumulation from sources such as hard water, and Petition 870250079886, dated 05 / 09 / 2025, page 12 / 204 7 / 97 additionally, they can help regulate the pathways that allow this class of materials to function as chemical exfoliants.

[0025] Applying hydroxy acids to hair, scalp, and facial and body skin from a rinse-off cleansing treatment is not trivial because these ingredients are highly water-soluble under typical formulation conditions, which often results in them being washed away during the rinsing process. Several key formulation parameters were discovered in the rinse-off cleansing treatment space, which enabled increased application of hydroxy acids to hair, scalp, and facial and body skin.

[0026] Additionally, non-limiting examples of hydroxy acids may include salicylic, citric, acetic, glycolic, lactic, tartaric, malic, mandelic, capric, caprylic, azelaic, and gluconic acids.

[0027] In the present invention, hydroxy acid may be present from about 0.5% to about 5%; from about % to about 4%; and from about 2% to about 3%. B. Detergent surfactant

[0028] The composition for personal care may contain from about 2% to about 13% of one or more surfactants; from about 2% to about 10% of one or more surfactants; from about 2% to about 8% of one or more surfactants; from about 2% to about 5% of one or more surfactants that provide cleaning performance to the composition. The surfactant system comprises an anionic surfactant and / or a combination of surfactants. Petition 870250079886, dated 05 / 09 / 2025, p. 13 / 204 8 / 97 anionic and / or a combination of anionic and co-surfactants selected from the group consisting of amphoteric, zwitterionic, nonionic surfactants and mixtures thereof. Several examples and descriptions of detergent surfactants are presented in U.S. Patent No. 8,440,605; in U.S. Patent Application Publication No. 2009 / 155383; and in U.S. Patent Application Publication No. 2009 / 0221463, which are incorporated herein by reference in their entirety.

[0029] Suitable anionic surfactants for use in the compositions are alkyl and alkyl ether sulfates. Other suitable anionic surfactants are water-soluble salts of organic products of the sulfuric acid reaction. Additional suitable anionic surfactants are the reaction products of fatty acids esterified with isethionic acid and neutralized with sodium hydroxide. Other similar anionic surfactants are described in U.S. Patents Nos. 2,486,921; 2,486,922; and 2,396,278, which are incorporated herein by reference in their entirety.

[0030] Examples of anionic surfactants for use in personal hair care formulations include ammonium lauryl sulfate, ammonium laureth sulfate, C10-15 ammonium pareth sulfate, C10-15 alkyl ammonium sulfate, C11-15 alkyl ammonium sulfate, ammonium decyl sulfate, ammonium deceth sulfate, ammonium undecyl sulfate, ammonium undeceth sulfate, triethylamine lauryl sulfate, triethylamine laureth sulfate, triethanolamine lauryl sulfate, laureth Petition 870250079886, dated 05 / 09 / 2025, page 14 / 204 9 / 97 triethanolamine sulfate, monoethanolamine lauryl sulfate, monoethanolamine laureth sulfate, diethanolamine lauryl sulfate, diethanolamine laureth sulfate, sodium lauryl sulfate, sodium laureth sulfate, C10-15 pareth sulfate, sodium C10-15 alkyl sulfate, sodium C11-15 alkyl sulfate, sodium decyl sulfate, sodium deceth sulfate, sodium undecyl sulfate, sodium undeceth sulfate, potassium lauryl sulfate, potassium laureth sulfate, potassium C10-15 pareth sulfate, potassium C10-15 alkyl sulfate, potassium C11-15 alkyl sulfate, potassium decyl sulfate, potassium deceth sulfate, potassium undecyl sulfate, potassium lauryl sarcosinate, sodium lauroyl sarcosinate, lauryl sarcosinate, cocoyl sarcosine, ammonium cocoyl sulfate, ammonium lauroyl sulfate, sodium cocoyl sulfate, sodium lauroyl sulfate, potassium cocoyl sulfate, potassium lauryl sulfate,Triethanolamine lauryl sulfate, triethanolamine lauryl sulfate, monoethanolamine cocoyl sulfate, monoethanolamine lauryl sulfate, sodium tridecylbenzene sulfonate, sodium dodecylbenzene sulfonate, sodium cocoyl isethionate, and combinations thereof. The anionic surfactant may be sodium lauryl sulfate and sodium laureth sulfate.

[0031] The composition of the present invention may also include anionic surfactants selected from the group consisting of: a) Ri O(CH2CHR3O)y SO3M; Petition 870250079886, dated 05 / 09 / 2025, page 15 / 204 10 / 97 b) CH3 (CH2)z CHR2 CH2 O (CH2 CHR3O)y SO3M; and c) mixtures thereof, where Ri represents CH3 (CH2H0, R2 represents H or a hydrocarbon radical comprising 1 to 4 carbon atoms such that the sum of the carbon atoms in ze R2 is 8, R3 is H or CH3, y is 0 to 7, the average value of y is about 1 when y is not (0), and M is a positively charged monovalent or divalent cation.

[0032] Suitable anionic alkyl sulfates and alkyl ether sulfate surfactants include, but are not limited to, those having branched alkyl chains, which are synthesized from C8 to C18 branched alcohols that may be selected from the group consisting of: Guerbet alcohols, alcohols derived from aldol condensation, oxo alcohols, oxo FT and mixtures thereof.Some non-limiting examples of branched alcohols include 2-alkyl oxo alcohols such as 2-methyl-1-undecanol, 2-ethyl-1-decanol, 2-propyl-1-nonanol, 2-butyl-1-octanol, 2-methyl-1-dodecanol, 2-ethyl-1-undecanol, 2-propyl-1-decanol, 2-butyl-1-nonanol, 2-pentyl-1-octanol, 2-pentyl-1-heptanol, and those sold under the trade names LIAL® (Sasol), ISALCHEM® (Sasol), and NEODOL® (Shell), and alcohols derived from the condensation of Guerbet and aldol such as 2-ethyl-1-hexanol, 2-propyl-1-butanol, 2-butyl-1-octanol, 2-butyl-1-decanol, 2-pentyl-1-nonanol, 2-hexyl-1-octanol, 2-hexyl-1-decanol, and those sold under the trade name ISOFOL® (Sasol) or sold as alcohol ethoxylates and alkoxylates under the trade names LUTENSOL XP® (BASF) and LUTENSOL XL® (BASF). Petition 870250079886, dated 05 / 09 / 2025, page 16 / 204 11 / 97

[0033] Anionic alkyl sulfates and alkyl ether sulfates may also include those synthesized from C8 to C18 branched alcohols derived from butylene or propylene that are sold under the trade names EXXAL™ (Exxon) and Marlipal® (Sasol). These include anionic surfactants of the trideceth-n sodium sulfate (STnS) subclass, wherein n is between about 0.5 and about 3.5. Examples of surfactants of this subclass are trideceth-2 sodium sulfate and trideceth-3 sodium sulfate. The composition of the present invention may also include tridecyl sodium sulfate.

[0034] The composition may contain additional anionic surfactants selected from the group consisting of sulfosuccinates, isethionates, sulfonates, sulfoacetates, glucose carboxylates, alkyl ether carboxylates, acyl taurates and mixtures thereof.

[0035] Non-limiting examples of acyl taurates may include sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium caproyl methyl taurate, sodium methyl oleoyl taurate, and combinations thereof.

[0036] The composition of the present invention may also include alkyl and anionic alkyl ether sulfosuccinates and / or dialkyl ether and dialkyl sulfosuccinates and mixtures thereof. The dialkyl and dialkyl ether sulfosuccinates may be linear or branched C6-15 dialkyl and dialkyl ether sulfosuccinates. The alkyl moieties may be symmetrical (i.e., the same alkyl moieties) or asymmetrical (i.e., different alkyl moieties). Some non-limiting examples Petition 870250079886, dated 05 / 09 / 2025, page 17 / 204 12 / 97 includes: disodium lauryl sulfosuccinate, disodium laureth sulfosuccinate, sodium bistridecyl sulfosuccinate, sodium dioctyl sulfosuccinate, sodium dihexyl sulfosuccinate, sodium dicyclohexyl sulfosuccinate, sodium diamyl sulfosuccinate, sodium diisobutyl sulfosuccinate, linear bis(tridecyl) sulfosuccinate and mixtures thereof.

[0037] In the personal care composition, an anionic surfactant may be present from about 2% to about % of one or more surfactants; from about 2% to about 8% of one or more surfactants; from about 2% to about 5% of one or more surfactants.

[0038] The composition for personal care may comprise a co-surfactant. The co-surfactant may be selected from the group consisting of amphoteric surfactants, zwitterionic surfactants, nonionic surfactants and mixtures thereof. The co-surfactant may include, but is not limited to, lauramidopropyl betaine, cocoamidopropyl betaine, lauryl hydroxy sultaine, sodium lauroamphoacetate, disodium cocoamphodiacetate, cocamide monoethanolamide and mixtures thereof.

[0039] The personal care composition may additionally comprise from about 0.25% to about 8%; from about 1% to about 7%; from about 2% to about 6% by weight of one or more amphoteric, zwitterionic, nonionic co-surfactants or a mixture thereof.

[0040] Amphoteric or zwitterionic surfactants suitable for use in the personal care composition of the present invention include those that are known Petition 870250079886, dated 05 / 09 / 2025, page 18 / 204 13 / 97 for its use in cleaning for personal care. Non-limiting examples of suitable zwitterionic or amphoteric surfactants are described in U.S. Patents Nos. 5,104,646 and 5,106,609, which are incorporated herein by reference in their entirety.

[0041] Suitable amphoteric cosurfactants for use in the composition include those surfactants described as derivatives of secondary and tertiary aliphatic amines, wherein the aliphatic radical may be a linear or branched chain and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms, and one contains an anionic group, such as carboxy, sulfonate, sulfate, phosphate or phosphonate. Suitable amphoteric surfactants include, but are not limited to, those selected from the group consisting of: sodium cocaminopropionate, sodium cocaminodipropionate, sodium cocoamphoacetate, sodium cocoamphodiacetate, sodium cocoampho-hydroxypropylsulfonate, sodium cocoamphopropionate, sodium cornamphopropionate, sodium lauraminopropionate, sodium lauroamphoacetate, sodium lauroamphodiacetate, sodium lauroamphohydroxypropylsulfonate, sodium lauroamphopropionate, sodium cornamphopropionate, sodium lauriminodipropionate, ammonium cocaminopropionate, ammonium cocoamphoacetate, ammonium cocoamphodiacetate, ammonium cocoamphohydroxypropylsulfonate, ammonium cocoamphopropionate, ammonium cornamphopropionate, lauraminopropionate ammonium, ammonium lauroamphoacetate, ammonium lauroamphodiacetate, lauroampho Petition 870250079886, dated 05 / 09 / 2025, page 19 / 204 14 / 97 ammonium hydroxypropylsulfonate, ammonium lauroamphopropionate, ammonium cornamphopropionate, ammonium lauriminodipropionate, triethanolamine cocaminopropionate, triethanolamine cocaminodipropionate, triethanolamine cocoamphoacetate, triethanolamine cocoamphohydroxypropylsulfonate, triethanolamine cocoamphopropionate, triethanolamine cornamphopropionate, triethanolamine lauraminopropionate, triethanolamine lauroamphoacetate, triethanolamine lauroamphohydroxypropylsulfonate, triethanolamine lauroamphopropionate, triethanolamine cornamphopropionate, triethanolamine lauriminodipropionate, cocoamphodipropionic acid, disodium caproamphodiacetate, disodium caproamphoadipropionate, disodium capryloamphodiacetate, disodium capryloamphodipriopionate, disodium cocoamphocarboxyethylhydroxypropylsulfonate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, disodium dicarboxyethylcocopropylenediamine, disodium laureth-5 carboxyamphodiacetate,disodium lauriminodipropionate, disodium lauroamphodiacetate, disodium lauroamphodipropionate, disodium oleoamphodipropionate, disodium PPG-2-isodecetyl-7 carboxyamphodiacetate, lauraminopropionic acid, lauroamphodipropionic acid, lauryl aminopropylglycine, lauryl diethylenediaminoglycine and mixtures thereof.

[0042] The composition may comprise a zwitterionic cosurfactant, wherein the zwitterionic cosurfactant is, Petition 870250079886, dated 05 / 09 / 2025, page 20 / 204 15 / 97 is a derivative of aliphatic compounds of quaternary ammonium, phosphonium and sulfonium, wherein the aliphatic radicals may be linear or branched chain and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms, and one contains an anionic group, such as carboxy, sulfonate, sulfate, phosphate or phosphonate. The zwitterionic surfactant may be selected from the group consisting of: cocamido ethyl betaine, cocamido propylamine oxide, cocamido propyl betaine, collagen hydrolyzed with cocamido propyl dimethylaminohydroxypropyl, collagen hydrolyzed with cocamido propyl dimonium hydroxypropyl, cocamido propyl hydroxy sultaine, cocobetaine starch amphopropionate, coco-betaine, coco-hydroxy sultaine, coco / oleamidopropyl betaine, coco-sultaine, lauramid propyl betaine, lauryl betaine, lauryl hydroxy sultaine, lauryl sultaine and mixtures thereof.

[0043] Suitable non-ionic surfactants for use in the present invention include those described in McCutcheon's Detergents and Emulsifiers, North American edition (1986), by Allured Publishing Corp., and in McCutcheon's Functional Materials, North American edition (1992). Suitable non-ionic surfactants for use in the personal care compositions of the present invention include, but are not limited to, polyoxyethylenated alkyl phenols, polyoxyethylenated alcohols, polyoxyethylenated polyoxypropylene glycols, glyceryl esters of alkanoic acids, polyglyceryl esters of acids Petition 870250079886, dated 05 / 09 / 2025, p. 21 / 204 16 / 97 alkanoic acids, propylene glycol esters of alkanoic acids, sorbitol esters of alkanoic acids, polyoxyethylene glycol esters of alkanoic acids, polyoxyethylene glycol esters of alkanoic acids, polyoxyethylene glycol alkanoic acids, alkanolamides, N-alkyl pyrrolidones, alkyl glycosides, alkyl polyglycosides, alkylamine oxides and polyoxyethylene silicones.

[0044] The co-surfactant may be a nonionic surfactant selected from the group including alkanolamides: Cocamide, methyl MEA cocamide, DEA cocamide, MEA cocamide, MIPA cocamide, DEA lauramide, MEA lauramide, MIPA lauramide, DEA myristamide, MEA myristamide, MEA PEG-20 cocamide, PEG-2 cocamide, PEG-3 cocamide, PEG-4 cocamide, PEG-5 cocamide, PEG-6 cocamide, PEG-7 cocamide, PEG-3 lauramide, PEG-5 lauramide, PEG-3 oleamide, PPG-2 cocamide, PPG-2 hydroxyethyl cocamide, PPG-2 hydroxyethyl isostearamide and mixtures thereof.

[0045] Representative polyoxyethyleninated alcohols include alkyl chains in the range of C9 to C16 and having from about 1 to about 110 alkoxy groups including, but not limited to, laureth-3, laureth-23, ceteth-10, steareth- 10, steareth-100, benet-10, all commercially available from Shell Chemicals, Houston, Texas, USA, under the trade names Neodol® 91, Neodol® 23, Neodol® 25, Neodol® 45, Neodol® 135, Neodol® 67, Neodol® PC 100, Neodol® PC 200, Neodol® PC 600, and mixtures thereof.

[0046] Polyoxyethylene fatty ethers are also commercially available. Petition 870250079886, dated 05 / 09 / 2025, p. 22 / 204 17 / 97 under the trade name Brij®, near Uniqema, Wilmington, Delaware, USA, including but not limited to Brij® 30, Brij® 35, Brij® 52, Brij® 56, Brij® 58, Brij® 72, Brij® 76, Brij® 78, Brij® 93, Brij® 97, Brij® 98, Brij® 721 and mixtures thereof.

[0047] Suitable alkyl glycosides and alkyl polyglycosides may be represented by the formula (S)n-OR, wherein S is a sugar moiety, such as glucose, fructose, mannose, galactose and the like; n is an integer from about 1 to about 1000, and R is a C8-C30 alkyl group. Examples of long-chain alcohols from which the alkyl group may be derived include decyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol and the like. Examples of these surfactants include alkyl polyglycosides, where S is a glucose moiety, R is a C8-20 alkyl group, and n is an integer from about 1 to about 9. Commercially available examples of these surfactants include decyl polyglycoside and lauryl polyglycoside, available under the trade names APG® 325 CS, APG® 600 CS, and APG® 625. CS), near Cognis, Ambler, PA, USA. Also useful to the present invention are sucrose ester-based surfactants such as sucrose cocoate and sucrose laurate, as well as alkyl polyglycosides, available under the trade names Triton™ BG-10 and Triton™ CG-110, from Dow Chemical Company, Houston, TX, USA.

[0048] Other suitable non-ionic surfactants for use in the present invention are glyceryl esters and polyglyceryl esters, including, but not limited to Petition 870250079886, dated 05 / 09 / 2025, p. 23 / 204 18 / 97 limiting it to C12 glyceryl monoesters, glyceryl monoesters of -22 saturated, unsaturated and branched-chain fatty acids such as glyceryl oleate, glyceryl monostearate, glyceryl monopalmitate, C12 glyceryl monobeane and mixtures thereof, and polyglyceryl esters of -22 saturated, unsaturated and branched-chain fatty acids such as polyglyceryl-4 isostearate, polyglyceryl-3 oleate, polyglyceryl-2 sesquioleate, triglyceryl diisostearate, diglyceryl monooleate, tetraglyceryl monooleate and mixtures thereof.

[0049] Sorbitan esters are also usable as nonionic surfactants here. Sorbitan esters of saturated, unsaturated, and C12-22 branched-chain fatty acids are useful in the present invention. These sorbitan esters generally comprise mixtures of mono-, di-, tri-esters, etc. Representative examples of suitable sorbitan esters include sorbitan monolaurate (SPAN® 20), sorbitan monopalmitate (SPAN® 40), sorbitan monostearate (SPAN® 60), sorbitan tristearate (SPAN® 65), sorbitan monooleate (SPAN® 80), sorbitan trioleate (SPAN® 85) and sorbitan isostearate.

[0050] Also suitable for use in the present invention are alkoxylated derivatives of sorbitan esters including, but not limited to, polyoxyethylene (20) sorbitan monolaurate (Tween® 20), polyoxyethylene (20) sorbitan monopalmitate (Tween® 40), polyoxyethylene (20) sorbitan monostearate (Tween® 60), polyoxyethylene (20) sorbitan monooleate Petition 870250079886, dated 05 / 09 / 2025, page 24 / 204 19 / 97 (Tween® 80), polyoxyethylene (4) sorbitan monolaurate (Tween® 21), polyoxyethylene (4) sorbitan monostearate (Tween® 61), polyoxyethylene (5) sorbitan monooleate (Tween® 81) and mixtures thereof, all available from Uniqema.

[0051] Alkyl phenol ethoxylates, including but not limited to nonylphenol ethoxylates (Tergitol™ NP-4, are also suitable for use in the present invention. NP-6, NP-7, NP-8, NP-9, NP-10, NP-11, NP-12, NP-13, NP- 15, NP-30, NP-40, NP-50, NP-55, NP-70 available from The Dow Chemical Company, Houston, TX, USA) and octyl phenol ethoxylates (Triton™ X-15, X-35, X-45, X- 114, X-100, X-102, X-165, X-305, X-405, X-705 available from The Dow Chemical Company, Houston, TX, USA).

[0052] Tertiary alkylamine oxides, including lauramine oxide and cocamine oxide, are also suitable for use in the present invention.

[0053] Some non-limiting examples of other anionic, zwitterionic, amphoteric and nonionic surfactants suitable for use in personal care compositions are described in McCutcheon's, Emulsifiers and Detergents, 1989 Annual, published by MC Publishing. Co., and in US patents no. 3,929,678 and 2,658,072; 2,438,091; 2,528,378, which are incorporated herein by reference in their entirety.

[0054] Suitable surfactant combinations comprise an average weight percentage of alkyl branching of about 0.5% to about 30%, Petition 870250079886, dated 05 / 09 / 2025, p. 25 / 204 20 / 97 alternatively from about 1% to about 25%, alternatively from about 2% to about 20%.

[0055] The surfactant combination may have a cumulative average weight percentage of C8 to C12 alkyl chain lengths of about 7.5% to about 25%, alternatively, from about 10% to about 22.5%, alternatively, from about 10% to about 20%.

[0056] The surfactant combination may have an average C8-C12 / C13-C18 alkyl chain ratio of about 3 to about 200, alternatively, from about 25 to about 175.5, alternatively, from about 50 to about 150, alternatively, from about 75 to about 125. C. Cationic polymers

[0057] The personal care composition also comprises a cationic polymer. These cationic polymers may include at least one of (a) a guar gum cationic polymer, (b) a non-guar galactomannan cationic polymer, (c) a tapioca cationic polymer, (d) a cationic copolymer of acrylamide monomers and cationic monomers, and / or (e) a synthetic, non-crosslinked cationic polymer, which may or may not form lyotropic liquid crystals upon combination with the detergent surfactant, (f) a cellulose cationic polymer. Additionally, the cationic polymer may be a mixture of cationic polymers.

[0058] The personal care composition may comprise a cationic polymer of guar gum, which is a galactomannan (guar) gum derivative. Petition 870250079886, dated 05 / 09 / 2025, page 26 / 204 21 / 97 cationically substituted. Guar gum for use in the preparation of these guar gum derivatives is typically obtained as a naturally occurring material from the seeds of the guar plant. The guar gum molecule itself is a linear chain mannan, which is branched at regular intervals with single-membered galactose units into alternating mannose units. The mannose units are linked to each other via β(1-4) glycosidic linkages. The galactose branching occurs via an α(1-6) linkage. Cationic derivatives of guar gums are obtained through the reaction between the hydroxyl groups of polygalactomannan and reactive quaternary ammonium compounds. The degree of substitution of the cationic groups on the guar gum structure needs to be sufficient to provide the necessary cationic charge density described above.

[0059] In the present invention, the cationic polymer may be, including but not limited to, a guar gum cationic polymer, having an average molecular weight of less than 2.2 million g / mol, or from about 150,000 to about 2.2 million g / mol, or from about 200,000 to about 2.2 million g / mol, or from about 250,000 to about 2.5 million g / mol, or from about 300,000 to about 1.2 million g / mol, or from about 700,000 to about 1 million g / mol. Additionally, the guar gum cationic polymer may have a charge density of about 0.2 to about 2.2 meq / g, or from about 0.3 to about 2.0 meq / g, or from about 0.4 to about Petition 870250079886, dated 05 / 09 / 2025, p. 27 / 204 22 / 97 1.8 meq / g; or from about 0.5 meq / g to about 1.8 meq / g.

[0060] The cationic polymer of guar gum may have a weight-average molecular weight of less than about 1.5 million g / mol and has a charge density of about 0.1 meq / g to about 2.5 meq / g. The cationic polymer of guar gum may have a weight-average molecular weight of less than 900 thousand g / mol or from about 150 thousand to about 800 thousand g / mol or from about 200 thousand to about 700 thousand g / mol or from about 300 thousand to about 700 thousand g / mol or from about 400 thousand to about 600 thousand g / mol, from about 150,000 to about 800,000 g / mol or from about 200,000 to about 700,000 g / mol or from about 300,000 to about 700,000 g / mol or from about 400,000 to about 600,000 g / mol. The cationic guar gum polymer may have a charge density of about 0.2 to about 2.2 meq / g or from about 0.3 to about 2.0 meq / g or from about 0.4 to about 1.8 meq / g; or from about 0.5 meq / g to about 1.5 meq / g.

[0061] Guar gum cationic polymer can be formed from quaternary ammonium compounds. Quaternary ammonium compounds for the formation of guar gum cationic polymer conform to the general formula 1: R5 I R4~ N~ R6z· R3 Petition 870250079886, dated 05 / 09 / 2025, page 28 / 204 23 / 97 where R3, R4 and R5 are methyl or ethyl groups; R6 is an epoxy alkyl group of general formula 2: H2C-CH-R7— or R6 is a halohydrin group of the general formula 3: X CH2CH R7— OH, where R7 is a C1 to C3 alkylene; X is chlorine or bromine, and Z is an anion such as Cl-, Br-, I-, or HSO4-.

[0062] The cationic polymer of guar gum conforms to the general formula 4: R4 R8O CH2CH R7 N+R52I I OH R3 where R8 is guar gum; and where R4, R5, R6 and R7 are as defined above; and where Z is a halogen. The cationic polymer of guar gum can conform to formula 5: R8O-CH2 CH-CH2N+(CH3)3C|· OH Petition 870250079886, dated 05 / 09 / 2025, page 29 / 204 24 / 97

[0063] Other suitable cationic guar gum polymers include cationic guar gum derivatives, such as guar gum hydroxypropyltrimonium chloride. The cationic guar gum polymer may be a hydroxypropyltrimonium chloride. Specific examples of guar gum hydroxypropyltrimonium chlorides include the series Jaguar® is commercially available from Solvay, for example, Jaguar® C-500, commercially available from Solvay. Jaguar® C-500 has a load density of 0.8 meq / g and a molecular weight of 500,000 g / mol. Another suitable guar gum hydroxypropyltrimonium chloride is: guar gum hydroxypropyltrimonium chloride which has a charge density of about 1.3 meq / g and a molecular weight of about 500,000 g / mol and is available from Solvay as Jaguar®Optima. Another suitable guar gum hydroxypropyltrimonium chloride is: guar gum hydroxypropyltrimonium chloride which has a charge density of about 0.7 meq / g and a molecular weight of about 1,500,000 g / mol and is available from Solvay as Jaguar®Excel. Another suitable guar gum hydroxypropyltrimonium chloride is: guar gum hydroxypropyltrimonium chloride which has a charge density of about 1.1 meq / g and a molecular weight of about 500,000 g / mol and is available from ASI, a charge density of about 1.5 meq / g and a molecular weight of about 500,000 g / mol, which is available from ASI.Other suitable guar gum hydroxypropyltrimonium chlorides are: Hi-Care 1000, which has a charge density of approximately. Petition 870250079886, dated 05 / 09 / 2025, page 30 / 204 25 / 97 has a charge density of 0.7 meq / g and a molecular weight of approximately 600,000 g / mol, and is available from Solvay; N-Hance 3269 and N-Hance 3270 have a charge density of approximately 0.7 meq / g and a molecular weight of approximately 425,000 g / mol, and are available from ASI; N-Hance 3196 has a charge density of approximately 0.8 meq / g and a molecular weight of approximately 1,100,000 g / mol, and is available from ASI. AquaCat CG518 has a charge density of approximately 0.9 meq / g and a molecular weight of approximately 50,000 g / mol, and is available from ASI. BF-13, which is a borate-free guar gum with a charge density of approximately 1.1 meq / g and a molecular weight of approximately 800,000, and BF-17, which is a borate-free guar gum with a charge density of approximately 1.5 meq / g and a molecular weight of approximately 800,000, are both available from ASI.

[0064] The personal care compositions of the present invention may comprise a galactomannan polymer derivative with a mannose-to-galactose weight ratio greater than 2:1 on a monomer-to-monomer basis; the galactomannan polymer derivative selected from the group consisting of a cationic galactomannan polymer derivative and an amphoteric galactomannan polymer derivative with a net positive charge. As used herein, the term cationic galactomannan refers to a galactomannan polymer to which a cationic group is added. The term amphoteric galactomannan refers to a galactomannan polymer to which a cationic group is added. Petition 870250079886, dated 05 / 09 / 2025, page 31 / 204 26 / 97 cationic group and an anionic group, so that the polymer has a net positive charge.

[0065] Galactomannan polymers are present in the endosperm of seeds from the Legume family. Galactomannan polymers are created from a combination of mannose monomers and galactose monomers. The galactomannan molecule is a linear chain mannan branched at regular intervals with galactose units of one member on specific mannose units. The mannose units are linked to each other via β(1-4) glycosidic linkages. The galactose branching occurs via an α(1-6) linkage. The ratio between mannose monomers and galactose monomers varies according to the plant species and is also affected by the climate. Non-guar galactomannan polymer derivatives of the present invention have a mannose to galactose ratio greater than 2:1 on a monomer-to-monomer basis. Suitable ratios of mannose to galactose can be greater than about 3:1, and the ratio of mannose to galactose can be greater than about 4:1.The analysis of mannose-to-galactose ratios is well known in the art and is typically based on measuring galactose content.

[0066] The gum for use in the preparation of non-guar galactomannan polymer derivatives is typically obtained from naturally occurring material such as seeds or grains from plants. Examples of various non-guar galactomannan polymers include, but are not limited to, tara gum (3 parts mannose / 1 part galactose), locust bean gum or carob gum (4 parts mannose / 1 part galactose). Petition 870250079886, dated 05 / 09 / 2025, p. 32 / 204 27 / 97 mannose / 1 part galactose) and cassia gum (5 parts mannose / 1 part galactose).

[0067] Non-guar galactomannan polymer derivatives can have a molecular weight of about 1000 to about 10,000,000 and / or from approximately 5,000 to approximately 3,000,000.

[0068] The personal care compositions of the invention may also include galactomannan polymer derivatives with a cationic charge density of about 0.5 meq / g to about 7 meq / g. The galactomannan polymer derivatives may have a cationic charge density of about 1 meq / g to about 5 meq / g. The degree of substitution of cationic groups on the galactomannan structure needs to be sufficient to provide the cationic charge density described above.

[0069] The galactomannan polymer derivative may be a cationic derivative of the non-guar galactomannan polymer, which is obtained by reaction between the hydroxyl groups of the polygalactomannan polymer and reactive quaternary ammonium compounds. Quaternary ammonium compounds suitable for use in the formation of cationic galactomannan polymer derivatives include those conforming to general formulas 1 to 5, as defined above.

[0070] The cationic non-guar galactomannan polymer derivatives formed from the reagents described above are represented by the general formula 6: Petition 870250079886, dated 05 / 09 / 2025, page 33 / 204 28 / 97 RJs L . R—0—CH2—CH—R5—N — R2Z' OH R3 where R is the gum. The cationic galactomannan derivative can be a hydroxypropyl trimethyl ammonium chloride gum, which can be more specifically represented by the general formula 7: R—O —CH—CHXfCHjJ^CJ ' OH

[0071] Alternatively, the galactomannan polymer derivative may be an amphoteric galactomannan polymer derivative having a net positive charge, obtained when the cationic galactomannan polymer derivative further comprises an anionic group.

[0072] Non-guar cationic galactomannan may have a mannose to galactose weight ratio greater than about 4:1, a molecular weight of about 1000 g / mol to about 10,000,000 g / mol, and / or of about 50,000 g / mol to about 1,000,000 g / mol, and / or of about 100,000 g / mol to about 900,000 g / mol, and / or of about 150,000 g / mol to 400,000 g / mol, and about a cationic charge density of about 1 meq / g to 5 meq / g, and / or of about 2 meq / g to 4 meq / g, and may be derived from a cassia plant. Petition 870250079886, dated 05 / 09 / 2025, p. 34 / 204 29 / 97

[0073] Personal care compositions may comprise water-soluble cationically modified starch polymers. As used herein, the term cationically modified starch refers to a starch to which a cationic group is added before the starch is degraded to a lower molecular weight, or to which a cationic group is added after the starch has been modified to obtain a desired molecular weight. The definition of the term cationically modified starch also encompasses amphoteric modified starches. The term amphoteric modified starch refers to a hydrolyzed starch to which both a cationic and an anionic group are added.

[0074] The cationically modified starch polymers disclosed herein have a percentage of bound nitrogen of about 0.5% to about 4%.

[0075] Cationically modified starch polymers for use in personal care compositions may have a molecular weight of about 850000 g / mol to about 1500000 g / mol and / or about 900000 g / mol to about 1500000 g / mol.

[0076] Personal care compositions may include cationically modified starch polymers having a charge density of about 0.2 meq / g to about 5 meq / g or about 0.2 meq / g to about 2 meq / g. Chemical modification to obtain such charge density includes, but is not limited to, the addition of amino and / or ammonium groups to the starch molecules. Some non-limiting examples of these ammonium groups may include substituents such as trimonium chloride hydroxy Petition 870250079886, dated 05 / 09 / 2025, p. 35 / 204 30 / 97 propyl, trimethyl hydroxypropyl ammonium chloride, dimethyl stearyl hydroxypropyl ammonium chloride, and dimethyl dodecyl hydroxypropyl ammonium chloride. See Solarek, DB, Cationic Starches in Modified Starches: Properties and Uses, Wurzburg, OB, Ed., CRC Press, Inc., Boca Raton, Florida, USA, 1986, pages 113 to 125. Cationic groups can be added to starch before degradation to a lower molecular weight or they can be added after such modification.

[0077] Cationically modified starch polymers generally have a degree of substitution of a cationic group of about 0.2 to about 2.5. As used herein, the degree of substitution of cationically modified starch polymers is the average measurement of the number of hydroxyl groups in each anhydroglucose unit that is derivatized by substituent groups. Since each anhydroglucose unit has three potentially available hydroxyl groups for substitution, the maximum possible degree of substitution is 3. The degree of substitution is expressed as the number of moles of substituent groups per mole of anhydroglucose units, on a molar average basis. The degree of substitution can be determined using well-known proton nuclear magnetic resonance (¹H NMR) spectroscopy methods. Suitable techniques of ¹H NMR are available.1H NMR incluem aquelas descritas em Observation on NMR Spectra of Starches in Dimethyl Sulfoxide, Iodine-Complexing, and Solvating in WaterDimethyl Sulfoxide, Qin-Ji Peng e Arthur S. Perlin, Carbohydrate Research, 160 (1987), 57 a 72; e An. Petição 870250079886, de 05 / 09 / 2025, pág. 36 / 204 31 / 97 Approach to the Structural Analysis of Oligosaccharides by NMR Spectroscopy, J. Howard Bradbury e J. Grant Collins, Carbohydrate Research, 71, (1979), 15 a 25.

[0078] The starch source before chemical modification can be chosen from a variety, such as tubers, legumes, cereals, and grains. Some non-limiting examples of these sources may include corn starch, wheat starch, rice starch, waxy corn starch, oat starch, cassava starch, waxy barley, waxy rice starch, glutenous rice starch, sweet rice starch, amioca, potato starch, tapioca starch, oat starch, sago starch, sweet rice, or mixtures of these items.

[0079] Cationically modified starch polymers can be selected from degraded cationic maize starch, cationic tapioca, cationic potato starch, and mixtures thereof. Alternatively, the cationically modified starch polymers are cationic maize starch and cationic tapioca.

[0080] Starch, before degradation or after modification to a lower molecular weight, may comprise one or more additional modifications. For example, these modifications may include crosslinking, stabilization reactions, phosphorylations, and hydrolyses. Stabilization reactions may include alkylation and esterification.

[0081] Cationically modified starch polymers can be incorporated into the composition in the form of hydrolyzed starch (e.g., acid, enzyme, or alkaline degradation), oxidized starch (e.g., Petition 870250079886, dated 05 / 09 / 2025, page 37 / 204 32 / 97 peroxide, peracid, hypochlorite, alkali, or any other oxidizing agent), starch that is physically or mechanically degraded (for example, through the input of thermomechanical energy from processing equipment), or combinations thereof.

[0082] An optimal form of starch is one that is readily soluble in water and forms a substantially clear solution (% transmittance from about 80 to 600 nm) in water. The transparency of the composition is measured by ultraviolet / visible (UV / VIS) spectrophotometry, which determines the absorption or transmission of UV / VIS light by a sample, using a Gretag Macbeth Color i 5 colorimeter, according to the related instructions. A wavelength of light of 600 nm has proven suitable for characterizing the degree of clarity of cosmetic compositions.

[0083] Cationically modified starch suitable for use in personal care compositions is available from known starch suppliers. Also suitable for use in personal care compositions is non-ionic modified starch which can be further derivatized into a cationically modified starch as known in the art. Other suitable modified starch-based starting materials can be quaternized, as known in the art, to produce the cationically modified starch polymer suitable for use in personal care compositions.

[0084] Starch degradation procedure: a fluid starch paste can be prepared by mixing starch Petition 870250079886, dated 05 / 09 / 2025, page 38 / 204 33 / 97 granular in water. The temperature is raised to about 35 °C. An aqueous solution of potassium permanganate is then added at a concentration of about 50 ppm, based on the amount of starch. The pH is raised to about 11.5 with sodium hydroxide, and the fluid paste is stirred sufficiently to prevent starch settling. Next, a solution of hydrogen peroxide diluted to about 30% in water is added at a content of about 1% peroxide, based on the amount of starch. The pH of about 11.5 is then restored by the addition of further sodium hydroxide. The reaction is complete after a period of about 1 to about 20 hours. The mixture is then neutralized with dilute hydrochloric acid. The degraded starch is recovered by filtration followed by washing and drying.

[0085] The personal care composition may comprise a cationic copolymer of an acrylamide monomer and a cationic monomer, wherein the copolymer has a charge density of about 1.0 meq / g to about 3.0 meq / g. The cationic copolymer may be a synthetic cationic copolymer of acrylamide monomers and cationic monomers.

[0086] The cationic copolymer may comprise: (i) an acrylamide monomer of the following formula AM: Petition 870250079886, dated 05 / 09 / 2025, page 39 / 204 34 / 97 Formula AM wherein R9 is H or C1-4 alkyl; and R10 and R11 are independently selected from the group consisting of H, C1-4 alkyl, CH2OCH3, CH2OCH2CH(CH3)2 and phenyl, or together are C3-6 cycloalkyl; and (ii) a cationic monomer according to formula CM: H2 C ch3 O^=C ch3ch3 OH CH3 NH IX-ch3L H2II Cdc < / v' N+--CH2CHCH2—N+--CH3 XCH3j w Xch3 The CM formula, where k = 1, each of v, v', and v'' is independently an integer from 1 to 6, w is zero or an integer from 1 to 10, and X is an anion.

[0087] The cationic monomer may conform to the formula CM, where k = 1, v = 3, ew = 0, z = 1 and X- and Cl- combine to form the following structure: Petition 870250079886, dated 05 / 09 / 2025, page 40 / 204 35 / 97 । ÇH3oh ÇHj ΜΗ--(CHj)3--N+--CHjCHCHj--N+--CH3 CH3C1' CH3C1'

[0088] The structure above can be called diquaternary. Alternatively, the cationic monomer can conform to the formula CM, and since v and v'' are each 3, v' = 1, w = 1, y = 1, and X- is Cl-, as: CH3 CH3OHch II h η IIL C---N--VC J--N+--CH2CHCH2—N+CHX' 3 | Cl-| ClCH3CH3

[0089] The structure above can be called a triquaternary.

[0090] Suitable acrylamide monomers include, but are not limited to, acrylamide or methacrylamide.

[0091] The cationic copolymer (b) may be AM:TRIQUAT which is a copolymer of acrylamide and 1,3-Propanodiammonium, N[2-[[[dimethyl[3-[(2-methyl-1-oxo-2propenyl)amino]propyl]ammonium]acetyl]amino]ethyl]2hydroxy-N,N,N',N',N'-pentamethyl-, trichloride. Petition 870250079886, dated 05 / 09 / 2025, page 41 / 204 36 / 97 AM:TRIQUAT is also known as polyquaternium-76 (PQ76). AM:TRIQUAT can have a charge density of 1.6 meq / g and a molecular weight of 1.1 million g / mol.

[0092] Additionally, the cationic copolymer may be of an acrylamide monomer and a cationic monomer, wherein the cationic monomer is selected from the group consisting of: dimethylaminoethyl (meth)acrylate, dimethylaminopropyl (meth)acrylate, di-tert-thiobutylaminoethyl (meth)acrylate, dimethylaminomethyl(meth)acrylamide, dimethylaminopropyl(meth)acrylamide; ethyleneimine, vinylamine, 2-vinylpyridine, 4-vinylpyridine; trimethyl ammonium ethyl (meth)acrylate chloride, trimethyl ammonium ethyl (meth)acrylate methyl sulfate, benzyl dimethyl ammonium ethyl (meth)acrylate chloride, 4-benzoylbenzyl dimethyl ammonium ethyl acrylate chloride, trimethyl ammonium ethyl (meth)acrylamido chloride, trimethyl ammonium propyl (meth)acrylamido chloride, vinylbenzyl trimethyl ammonium chloride, diallyl dimethyl ammonium chloride and mixtures thereof.

[0093] The cationic copolymer may comprise a cationic monomer selected from the group consisting of: cationic monomers include trimethylammonium ethyl (meth)acrylate chloride, trimethylammonium ethyl (meth)acrylate methyl sulfate, dimethylammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyl dimethylammonium ethyl acrylate chloride, trimethylammonium ethyl (meth)acrylamido chloride, trimethylammonium propyl (meth)acrylamido chloride, trimethylammonium vinylbenzyl chloride and mixtures thereof. Petition 870250079886, dated 05 / 09 / 2025, page 42 / 204 37 / 97

[0094] The cationic copolymer may be water-soluble. The cationic copolymer is formed from (1) copolymers of (meth)acrylamide and (meth)acrylamide-based cationic monomers and / or hydrolysably stable cationic monomers, (2) terpolymers of (meth)acrylamide, (meth)acrylic acid cationic esters and (meth)acrylamide-based monomers and / or hydrolysably stable cationic monomers. The (meth)acrylic acid cationic esters may be cationized (meth)acrylic acid esters containing a quaternized N atom. Cationized esters of (meth)acrylic acid containing a quaternized N atom can be quaternized dialkyl amino alkyl (meth)acrylates with C1 to C3 alkyl and alkylene groups.Suitable cationized esters of (meth)acrylic acid containing a quaternized N atom may be selected from the group consisting of: ammonium salts of dimethyl amino methyl (meth)acrylate, dimethyl amino ethyl (meth)acrylate, dimethyl amino propyl (meth)acrylate, diethyl amino methyl (meth)acrylate, diethyl amino ethyl (meth)acrylate; and diethylaminopropyl (meth)acrylate quaternized with methyl chloride. The cationized esters of (meth)acrylic acid containing a quaternized N atom may be dimethylamino ethyl acrylate, which is quaternized with an alkyl halide, or with methyl chloride or benzyl chloride or dimethyl sulfate (ADAME-Quat). The cationic monomer when based on (meth)acrylamides may be dialkylamino alkyl(meth)acrylamides quaternized with C1 to C3 in the... Petition 870250079886, dated 05 / 09 / 2025, page 43 / 204 38 / 97 alkyl and alkylene groups, or dimethylaminopropylacrylamide, which is quaternized with an alkyl halide or methyl chloride or benzyl chloride or dimethyl sulfate.

[0095] The suitable cationic monomer based on a (meth)acrylamide includes dialkylamino alkyl(meth)acrylamide quaternized with C1 to C3 alkyl and alkylene groups. The cationic monomer based on a (meth)acrylamide may be dimethylaminopropylacrylamide, which is quaternized with an alkyl halide, specifically methyl chloride or benzyl chloride or dimethyl sulfate.

[0096] The cationic monomer may be a hydrolyzed cationic monomer. Hydrolyzed cationic monomers may be, in addition to dialkyl amino alkyl(meth)acrylamide, all monomers that can be observed to be stable in the OECD hydrolysis test. The hydrolyzed cationic monomer may be selected from the group consisting of: diallyl dimethylammonium chloride and water-soluble cationic styrene derivatives.

[0097] The cationic copolymer is a terpolymer of acrylamide, 2-dimethylammoniummethyl (meth)acrylate quaternized with methyl chloride (ADAME-Q) and 3-dimethylammoniumpropyl(meth)acrylamide quaternized with methyl chloride (DIMAPA-Q). The cationic copolymer can be formed from acrylamide and acrylamidopropyltrimethylammonium chloride, wherein the chloride of Petition 870250079886, dated 05 / 09 / 2025, page 44 / 204 39 / 97 acrylamidopropyltrimethylammonium has a charge density of about 1.0 meq / g to about 3.0 meq / g.

[0098] The cationic copolymer may have a charge density of about 1.1 meq / g or about 2.5 meq / g or about 1.1 meq / g or about 2.3 meq / g or about 1.2 meq / ga to about 2.2 meq / g or from about 1.2 meq / ga to about 2.1 meq / g or from about 1.3 meq / ga to about 2.0 meq / g or from about 1.3 meq / ga to about 1.9 meq / g.

[0099] The cationic copolymer may have a molecular weight of about 100 thousand g / mol to about 1.5 million g / mol or about 300 thousand g / mol to about 1.5 million g / mol or about 500 thousand g / mol to about 1.5 million g / mol or about 700 thousand g / mol to about 1.0 million g / mol or about 900 thousand g / mol to about 1.2 million g / mol.

[0100] The cationic copolymer may be a trimethylammoniopropylmethacrylamide chloride-N-acrylamide copolymer, which is also known as AM:MAPTAC. AM:MAPTAC may have a charge density of approximately 1.3 meq / g and a molecular weight of approximately 1.1 million g / mol. The cationic copolymer can be AM:ATPAC. AM:ATPAC can have a charge density of approximately 1.8 meq / g and a molecular weight of approximately 1.1 million g / mol. (a) Cationic synthetic polymers

[0101] The personal care composition may comprise a synthetic polymer that may be formed from i) one or more cationic monomeric units and, optionally, Petition 870250079886, dated 05 / 09 / 2025, page 45 / 204 40 / 97 ii) one or more monomeric units that have a negative charge and / or iii) a non-ionic monomer, wherein the subsequent charge of the copolymer is positive. The ratio between the three types of monomers is given by m, p, and q, where m is the number of cationic monomers, p is the number of monomers that have a negative charge, and q is the number of non-ionic monomers.

[0102] Cationic polymers can be water-soluble or water-dispersible, non-crosslinked, synthetic cationic polymers that have the following structure: where A can be one or more of the following cationic moieties: Petition 870250079886, dated 05 / 09 / 2025, page 46 / 204 41 / 97 where @ = starch, alkylamido, ester, ether, alkyl or alkylaryl; where Y = C1-C22 alkyl, alkoxy, alkylidene, alkyl or aryloxy; where ψ = C1-C22 alkyl, alkyloxy, alkylaryl or alkylaryloxy;. where Z = C1-C22 alkyl, alkyloxy, aryl or aryloxy; where R1 = H, C1-C4 linear or branched alkyl; where s = 0 or 1, n = 0 or > 1; where T and R7 = C1-C22 alkyl; and X- = halogen, hydroxide, alkoxide, sulfate or alkyl sulfate.

[0103] Where the monomer that has a negative charge is defined by R2' = H, C1-C4 linear or branched alkyl and R3 as: Petition 870250079886, dated 05 / 09 / 2025, page 47 / 204 D | Q | 0 (CH2)u I > (CH2)2 | (CH2)2 CH3N -CH3 CH3N ~CH3 1 0 + J t + (CH2)u 1 CH2 HO-P=OJIC=O 1 1 o- 1 0- 1 0- N-CH3 I (CH2)2o=s=o Given that D = 0, N, or S; where Q = NH2 or O; where u = 1 a6; where t = 0 to 1; and where J = oxygenated functional group containing the following elements: P, S, C.

[0104] Where the non-ionic monomer is defined by R2'' = H, C1-C4 linear or branched alkyl, R6 = linear or branched alkyl, alkylaryl, aryloxy, alkyloxy, alkylaryloxy and β is defined as [G=G' 1 L G” ; and where G' and G' ' are, independently of each other, 0, S or NH and L = 0 or 1.

[0105] Examples of cationic monomers include aminoalkyl (meth)acrylates, (meth)aminoalkyl (meth)acrylamides; monomers comprising at least Petition 870250079886, dated 05 / 09 / 2025, page 48 / 204 43 / 97 a secondary, tertiary or quaternary amine function, or a heterocyclic group containing a nitrogen atom, vinyl amine or ethyleneimine; diallyl dialkyl ammonium salts; mixtures thereof, their salts and macromonomers derived therefrom.

[0106] Additional examples of cationic monomers include dimethyl aminoethyl (meth)acrylate, dimethyl aminopropyl (meth)acrylate, diterthiobutylaminoethyl (meth)acrylate, dimethylaminomethyl (meth)acrylamide, dimethyl aminopropyl (meth)acrylamide, ethyleneimine, vinylamine, 2-vinylpyridine, 4-vinylpyridine, trimethyl ammonium ethyl (meth)acrylate chloride, trimethyl ammonium ethyl (meth)acrylate methylsulfate, dimethyl ammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyl dimethyl ammonium ethyl acrylate chloride, trimethyl ammonium ethyl (meth)acrylamido chloride, trimethyl ammonium propyl (meth)acrylamido chloride, vinylbenzyl trimethyl ammonium chloride, diallyl dimethyl ammonium chloride.

[0107] Cationic monomers include those comprising a quaternary ammonium group of the formula NR3+, wherein R, which is identical or different, represents a hydrogen atom, an alkyl group comprising from 1 to 10 carbon atoms or a benzyl group, optionally bearing a hydroxyl group, and comprising an anion (contraion). Examples of anions are halides, such as chlorides, bromides, sulfates, hydrosulfates, alkyl sulfates (e.g., comprising from 1 to 6 carbon atoms), phosphates, citrates, formates, and acetates. Petition 870250079886, dated 05 / 09 / 2025, page 49 / 204 44 / 97

[0108] Preferred cationic monomers include trimethyl ammonium ethyl (meth)acrylate chloride, trimethyl ammonium ethyl (meth)acrylate methyl sulfate, dimethyl ammonium ethyl (meth)acrylate benzyl chloride, 4-benzoylbenzyl dimethyl ammonium ethyl acrylate chloride, trimethyl ammonium ethyl (meth)acrylamido chloride, trimethyl ammonium propyl (meth)acrylamido chloride, trimethyl ammonium vinylbenzyl chloride.

[0109] Additional suitable cationic monomers include trimethylammonium propyl(meth)acrylamido chloride.

[0110] Examples of monomers with a negative charge include alpha ethylenically unsaturated monomers comprising a phosphate or phosphonate group, alpha ethylenically unsaturated monocarboxylic acids, monoalkyl esters of alpha ethylenically unsaturated dicarboxylic acids, monoalkylamides of alpha ethylenically unsaturated dicarboxylic acids, alpha ethylenically unsaturated compounds comprising a sulfonic acid group, and salts of alpha ethylenically unsaturated compounds comprising a sulfonic acid group.

[0111] Suitable monomers with a negative charge include acrylic acid, methacrylic acid, vinyl sulfonic acid, vinyl sulfonic acid salts, vinylbenzene sulfonic acid, vinylbenzene sulfonic acid salts, alpha-acrylamidomethyl propanesulfonic acid, alpha-acrylamidomethyl propanesulfonic acid salts, 2-sulfoethyl methacrylate, 2-sulfoethyl methacrylate salts, acrylamido-2-methylpropanesulfonic acid (AMPS), acid salts Petition 870250079886, dated 05 / 09 / 2025, page 50 / 204 45 / 97 acrylamido-2-methylpropanesulfonic acid and styrene sulfonate (SS).

[0112] Examples of nonionic monomers include vinyl acetate, amides of alpha ethylenically unsaturated carboxylic acids, esters of alpha ethylenically unsaturated monocarboxylic acids with a hydrogenated or fluorinated alcohol, (meth)acrylate of polyethylene oxide (i.e., polyethoxylated (meth)acrylic acid), monoalkyl esters of alpha ethylenically unsaturated dicarboxylic acids, monoalkylamides of alpha ethylenically unsaturated dicarboxylic acids, vinyl nitriles, vinyl amine amides, vinyl alcohol, vinyl pyrrolidone, and vinyl aromatic compounds.

[0113] Suitable nonionic monomers include styrene, acrylamide, methacrylamide, acrylonitrile, methyl acrylate, ethyl acrylate, n-propylacrylate, n-butyl acrylate, methyl methacrylate, ethyl methacrylate, n-propyl methacrylate, n-butyl methacrylate, 2-ethylhexyl acrylate, 2-ethylhexyl methacrylate, 2-hydroxyethyl acrylate and 2-hydroxyethyl methacrylate.

[0114] The anionic counterion (X-) associated with the synthetic cationic polymers may be any known counterion, provided that the polymers remain soluble or dispersible in water, in the personal care composition, or in a coacervate phase of the personal care composition, and provided that the counterions are physically and chemically compatible with the essential components of the personal care composition or otherwise not Petition 870250079886, dated 05 / 09 / 2025, page 51 / 204 46 / 97 unduly impair the performance, stability, or aesthetics of the product. Some non-limiting examples of these counterions include halides (e.g., chlorine, fluorine, bromine, iodine), sulfate, and methyl sulfate.

[0115] The cationic polymer described in the present invention can assist in providing damaged hair, particularly chemically treated hair, with a replacement hydrophobic F layer. The microscopically thin F layer provides natural resistance to weathering while helping to retain moisture and prevent further damage. Chemical treatments damage the hair cuticle and remove its protective F layer. As the F layer is removed, the hair becomes increasingly hydrophilic. It has been found that when lyotropic liquid crystals are applied to chemically treated hair, the hair becomes more hydrophobic and newer, both in appearance and to the touch. Without adhering to any particular theory, it is believed that the lyotropic liquid crystal complex creates a hydrophobic layer or film that coats the hair fibers, protecting them in a manner very similar to how the natural F layer does.The hydrophobic layer restores the hair to a generally new and healthier-looking state. Lyotropic liquid crystals are formed by combining the synthetic cationic polymers described herein with the aforementioned anionic detergent surfactant component of the personal care composition. The synthetic cationic polymer has a... Petition 870250079886, dated 05 / 09 / 2025, page 52 / 204 47 / 97 relatively high charge density. It should be noted that some synthetic polymers that have a relatively high cationic charge density do not form lyotropic liquid crystals, mainly due to their abnormal linear charge densities. Such synthetic cationic polymers are described in WO 94 / 06403 by Reich et al. The synthetic polymers described herein can be formulated into a stable personal care composition that provides optimized conditioning performance for damaged hair.

[0116] Synthetic cationic polymers that can form lyotropic liquid crystals may have a cationic charge density of about 2 meq / g to about 7 meq / g or about 3 meq / g to about 7 meq / g or about 4 meq / g to about 7 meq / g. The cationic charge density may be about 6.2 meq / g. The polymers also have a molecular weight of about 1000 to about 5000000 and / or about 10000 to about 1,500,000 and / or from approximately 100,000 to approximately 1,500,000.

[0117] Synthetic cationic polymers that provide improved conditioning and deposition of beneficial agents, but do not necessarily form lyotropic liquid crystals, may have a cationic charge density of about 0.7 meq / gm to about 7 meq / gm, and / or about 0.8 meq / gm to about 5 meq / gm, and / or about 1.0 meq / gm to about 3 meq / gm. The polymers also have a molecular weight of about 1000 to about 1500000, about 10000 to about 1500000, and about 100000 to about 1500000. Petition 870250079886, dated 05 / 09 / 2025, page 53 / 204 48 / 97

[0118] Suitable cationic cellulose polymers are hydroxyethyl cellulose salts reacted with substituted trimethyl ammonium epoxide, cited in the industry (CTFA) as polyquaternium-10 and available from Dow / Amerchol Corp. (Edison, NJ, USA) in their Polymer LR, JR, and KG series. Non-limiting examples include: JR-400, JR-125, JR-30M, KG-30M, JP, LR-400, and mixtures thereof. Other suitable types of cationic cellulose include polymeric quaternary ammonium salts of hydroxyethyl cellulose reacted with lauryl dimethyl ammonium substituted epoxide, industry referenced (CTFA) as Polyquaternium-24. These materials are available from Dow / Amerchol Corp. under the trade name Polymer LM200. Other suitable types of cationic cellulose include polymeric quaternary ammonium salts of hydroxyethyl cellulose reacted with lauryl dimethyl ammonium substituted epoxide and trimethyl ammonium substituted epoxide, industry referenced (CTFA) as Polyquaternium-67. These materials are available from Dow / Amerchol Corp. under the trade name SoftCAT Polymer SL-5, SoftCAT Polymer SL-30, Polymer SL-60, Polymer SL-100, Polymer SK-L, Polymer SK-M, Polymer SKMH and Polymer SK-H.

[0119] Suitable cationic cellulose polymers may have a cationic charge density of about 0.5 meq / g to about 2.5 meq / g, and / or about 0.6 meq / g to about 2.2 meq / g, or about 0.6 meq / g to about 2.0 meq / g. Additionally, the cationic charge density may be about 1.9 meq / g. The polymers Petition 870250079886, dated 05 / 09 / 2025, page 54 / 204 49 / 97 may also have a molecular weight of about 200,000 to about 3,000,000, and / or from about 300,000 to about 2,200,000, from about 1,000,000 to about 2,200,000, and / or from about 3,000,000 to about 1,500,000. The cationic cellulose polymer may have a cationic charge density of about 1.7 to about 2.1 meq / g and a molecular weight of about 1,000,000 to about 2,000,000.

[0120] The concentration of cationic polymers is in the range of about 0.01% to about 5%, of about 0.08% to about 3%, from about 0.1% to about 2% and / or from about 0.2% to about 1% by weight of the composition for personal care. Thickening polymers

[0121] The personal care composition may comprise a thickening polymer to increase the viscosity of the composition. Suitable thickening polymers may be used. The personal care composition may comprise from about 0.25% to about % of a thickening polymer, from about 0.5% to about 8% of a thickening polymer, from about 1.0% to about 5% of a thickening polymer, and from about 1% to about 4% of a thickening polymer. The modifying thickening polymer may be polyacrylate or polyacrylamide thickeners. The thickening polymer may be an anionic thickening polymer.

[0122] The composition for personal care may comprise thickening polymers that are homopolymers based on acrylic acid, methacrylic acid or other related derivatives; examples Petition 870250079886, dated 05 / 09 / 2025, page 55 / 204 50 / 97 non-limiting compounds include polyacrylate, polymethacrylate, polyethyl acrylate, and polyacrylamide.

[0123] Thickening polymers may be alkali-expandable acrylic copolymers and hydrophobically modified alkali-expandable acrylic copolymers or methacrylate copolymers; Non-limiting examples include acrylic acid / acrylonitrogen copolymer, acrylates / steareth-20 itaconate copolymer, acrylates / ceteth-20 itaconate copolymer, acrylates / aminoacrylates / C10-30 alkyl PEG-20 itaconate copolymer, acrylates / aminoacrylates copolymer, acrylates / steareth-20 methacrylate copolymer, acrylates / beenet-25 methacrylate copolymer, acrylates / steareth-20 methacrylate crosslinked polymer, acrylates / beenet-25 methacrylate / HEMA crosslinked polymer, acrylates / vinyl neodecanoate crosslinked polymer, acrylates / vinyl isodecanoate crosslinked polymer, acrylates / palmet-25 acrylate copolymer, acrylic acid / acrylamidomethylpropane copolymer. sulfonic acid and cross-linked acrylate / C10-C30 alkyl acrylate polymer.

[0124] Thickening polymers can be soluble cross-linked acrylic polymers; a non-limiting example includes carbomers.

[0125] Thickening polymers can be associative polymeric thickeners; non-limiting examples include: hydrophobically modified alkali-expandable emulsions; non-limiting examples include hydrophobically modified polyacrylates Petition 870250079886, dated 05 / 09 / 2025, page 56 / 204 51 / 97 modified; hydrophobically modified polyacrylic acids and hydrophobically modified polyacrylamides; hydrophobically modified polyethers, these materials having a hydrophobic agent that can be selected from cetyl, stearyl, oleayl, and combinations thereof.

[0126] Thickening polymers can be used in combination with polyvinylpyrrolidone, crosslinked polyvinylpyrrolidone and derivatives. Thickening polymers can be combined with polyvinyl alcohol and derivatives. Thickening polymers can be combined with polyethylene imine and its derivatives.

[0127] Thickening polymers can be combined with alginic acid-based materials; non-limiting examples include sodium alginate and propylene glycol esters of alginic acid.

[0128] Thickening polymers can be used in combination with polyurethane polymers; non-limiting examples include: hydrophobically modified alkoxylated urethane polymers; non-limiting examples include PEG-150 / decyl alcohol / SMDI copolymer, PEG-150 / stearyl alcohol / SMDI copolymer, polyurethane-39.

[0129] Thickening polymers can be combined with associative polymeric thickeners; non-limiting examples include: hydrophobically modified cellulose derivatives; and a hydrophilic moiety of repeating ethylene oxide groups with repeating units of about 10 to about 300, of about Petition 870250079886, dated 05 / 09 / 2025, page 57 / 204 52 / 97 to about 200, from about 40 to about 150. Non-limiting examples of this class include PEG-120 methylglucose dioleate, PEG-(40 or 60) sorbitan tetraoleate, PEG-150 pentaerythrityl tetrastearate, PEG-55 propylene glycol oleate, PEG-150 distearate.

[0130] Thickening polymers can be combined with cellulose and derivatives; non-limiting examples include microcrystalline cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl cellulose; nitrocellulose; cellulose sulfate; cellulose powder; hydrophobically modified celluloses.

[0131] Thickening polymers can be combined with guar gum and guar gum derivatives; non-limiting examples include hydroxypropyl guar and hydroxypropyltrimonium chloride of hydroxypropyl guar gum.

[0132] Thickening polymers can be combined with polyethylene oxide; polypropylene oxide; and POE-PPO copolymers.

[0133] Thickening polymers can be combined with polyalkylene glycols distinguished by the general formula: H(OCH2CH)n--OH where R is hydrogen, methyl or mixtures thereof, and additionally hydrogen, en is an integer that has a mean of 2000 to 180000, or 7000 to 90000, or Petition 870250079886, dated 05 / 09 / 2025, page 58 / 204 53 / 97 from 7000 to 45000. Non-limiting examples of this class include PEG-7M, PEG-14M, PEG-23M, PEG-25M, PEG-45M, PEG-90M, or PEG-100M.

[0134] Thickening polymers can be combined with silicas; non-limiting examples include pyrolyzed silica, precipitated silica, and silica treated with a silicone surface.

[0135] Thickening polymers can be combined with water-expandable clays; non-limiting examples include laponite, bentolite, montmorillonite, smectite and hectonite.

[0136] Thickening polymers can be combined with gums; non-limiting examples include xanthan gum, guar gum, hydroxypropyl guar gum, gum arabic, tragacanth, galactan, locust bean gum, karaya gum and locust bean gum.

[0137] Thickening polymers can be combined with dibenzylidene sorbitol, karaggenan, pectin, agar, quince seed (Cydonia oblonga Mill), starch (from rice, corn, potato, wheat, etc.), starch derivatives (e.g., carboxymethyl starch, methyl hydroxypropyl starch), seaweed extracts, dextran, succinoglucan, and pulleran.

[0138] Non-limiting examples of thickening polymers include acrylamide / ammonium acrylate (and) polyisobutene (and) polysorbate 20 copolymer; acrylamide / sodium acryloyl dimethyl taurate / isohexadecane / polysorbate 80 copolymer, ammonium acryloyl dimethyl taurate / VP copolymer, sodium acrylate / sodium acryloyl dimethyl taurate copolymer, Petition 870250079886, dated 05 / 09 / 2025, p. 59 / 204 54 / 97 acrylate copolymer, acrylate-4 crosspolymer, acrylate-3 crosspolymer, acrylate / beenet-25 methacrylate copolymer, acrylate / C10-C30 alkyl acrylate crosspolymer, acrylate / steareth-20 itaconate copolymer, ammonium polyacrylate / isohexadecane / PEG-40 castor oil; carbomer, sodium carbomer, crosslinked polyvinylpyrrolidone (PVP), polyacrylamide / C13-14 isoparaffin / laureth-7, polyacrylate 13 / polyisobutene / polysorbate 20, polyacrylate-6 crosspolymer, polyamide-3, polyquaternium-37 (and) hydrogenated polydecene (and) trideceth-6, acrylamide / sodium acryloyl dimethyl taurate / acrylic acid copolymer, sodium acrylate / acryloyl dimethyl taurate / dimethylacrylamide, crosspolymer (and) isohexadecane (and) polysorbate 60, sodium polyacrylate. Examples of commercially available thickening polymers include ACULYN™ 28, ACULYN™ 33, ACULYN™ 88, ACULYN™ 22, ACULYN™ Excel, Carbopol® Aqua SF-1, Carbopol® ETD 2020, Carbopol® Ultrez 20, Carbopol® Ultrez 21, Carbopol® Ultrez 10, Carbopol® Ultrez 30, Carbopol® 1342, Carbopol® Aqua SF2 Polymer, Sepigel™ 305, Simulgel™ 600, Sepimax Zen, Carbopol® SMART 1000, Rheocare® TTA, Rheomer® SC-Plus, STRUCTURE® PLUS, Aristoflex® AVC, Stabylen 30 and combinations thereof. Gel net

[0139] In the present invention, a gel network may be present. The gel network component of the present invention comprises at least one fatty amphiphile. As used herein, fatty amphiphile refers to a compound Petition 870250079886, dated 05 / 09 / 2025, p. 60 / 204 55 / 97 having a hydrophobic tail group defined as an alkyl, alkenyl (containing up to 3 double bonds), aromatic alkyl or branched alkyl group of length C12 to C70 and a hydrophilic head group that does not make the compound soluble in water, and the compound also has a neutral net charge at the pH of the composition for personal care.

[0140] The personal care compositions of the present invention comprise fatty amphiphile as part of the pre-formed dispersed gel network phase in an amount of about 0.05% to about 14%, preferably about 0.5% to about 10% and about 1% to about 8% by weight of the personal care composition.

[0141] According to the present invention, suitable fatty amphiphiles, or suitable mixtures of two or more fatty amphiphiles, have a melting point of at least about 27 °C. The melting point of the surfactants used according to the present invention can be measured by a standard melting point method, as described in the US Pharmacopeia, USP-NF, General Chapter <741> Melting range or temperature. The melting point of a mixture of two or more materials is determined by mixing the two or more materials at a temperature above their respective melting points and then allowing the mixture to cool. If the resulting composite is a homogeneous solid at a temperature below about 27 °C, then the mixture has a melting point suitable for use in the present invention. A mixture of two or more fatty amphiphiles, the mixture comprising at least one fatty amphiphile having Petition 870250079886, dated 05 / 09 / 2025, p. 61 / 204 56 / 97 an individual melting point lower than about 27 °C, is still suitable for use in the present invention provided that the composite melting point of the mixture is at least about 27 °C.

[0142] Suitable fatty amphiphiles of the present invention include fatty alcohols, alkoxylated fatty alcohols, fatty phenols, alkoxylated fatty phenols, fatty amides, alkoxylated fatty amides, fatty amines, alkylamidoalkylamines fatty acids, alkoxylated fatty amines, fatty carbamates, fatty amine oxides, fatty acids, alkoxylated fatty acids, fatty diesters, fatty sorbitan esters, fatty sugar esters, methyl glycoside esters, fatty glycol esters, mono-, di- and triglycerides, polyglycerin fatty esters, alkyl glyceryl ethers, propylene glycol fatty acid esters, cholesterol, ceramides, fatty silicone waxes, fatty glucose amides, phospholipids and combinations thereof.

[0143] The composition for personal care may comprise fatty alcohol gel networks. These gel networks are formed by combining fatty alcohols and surfactants in a ratio of about 1:1 to about 40:1, about 2:1 to about 20:1 and / or about 3:1 to about 10:1. The formation of a gel network involves heating a dispersion of fatty alcohol in water with the surfactant to a temperature above the melting point of the fatty alcohol. During the mixing process, the fatty alcohol melts, allowing the surfactant to partition into fatty alcohol droplets. The surfactant carries water along with it into the alcohol. Petition 870250079886, dated 05 / 09 / 2025, p. 62 / 204 57 / 97 fatty. This transforms the isotropic fatty alcohol droplets into liquid crystalline phase droplets. When the mixture is cooled below the chain melting temperature, the liquid crystalline phase is converted into a solid crystalline gel network. The gel network contributes a stabilizing benefit to cosmetic creams and hair conditioners. Additionally, it provides the conditioning feel benefits of hair conditioners.

[0144] Fatty alcohol may be included in the fatty alcohol gel network in a content, by weight, of about 0.05% by weight to about 14% by weight. For example, fatty alcohol may be present in an amount in the range of about 1% by weight to about 10% by weight and / or about 6% by weight to about 8% by weight.

[0145] Useful fatty alcohols here include those having from about 10 to about 40 carbon atoms, from about 12 to about 22 carbon atoms, from about 16 to about 22 carbon atoms, and / or from about to about 18 carbon atoms. These fatty alcohols may be straight-chain or branched, and may be saturated or unsaturated. Some non-limiting examples of fatty alcohols include cetyl alcohol, stearyl alcohol, behenyl alcohol, and mixtures of these substances. Mixtures of cetyl and stearyl alcohols in ratios of about 20:80 to about 80:20 are suitable.

[0146] Preparation of gel network: A container is filled with water and the water is heated to about 74 °C. Cetyl alcohol, stearyl alcohol, and surfactant Petition 870250079886, dated 05 / 09 / 2025, page 63 / 204 58 / 97 SLES are added to heated water. After incorporation, the resulting mixture is passed through a heat exchanger so that the mixture is cooled to about 35 °C. After cooling, the fatty alcohols and surfactant crystallize to form a crystalline gel network. Table 1 provides the components and their respective quantities for the example gel network composition. Table 1 Gel network components Ingredient %, by weight Water 78.27% Cetyl alcohol 4.18% Stearyl alcohol 7.52% Sodium laureth-3 sulfate (28% active) 10.00% 5-chloro-2-methyl-4-isothiazolin-3-one, Kathon CG 0.03% 1. Water-miscible solvents

[0147] The vehicle useful in the composition for personal care may include water and water solutions of lower alkyl alcohols, polyhydric alcohols, ketones having 3 to 4 carbon atoms, C1-C6 esters of C1-C6 alcohols, sulfoxides, amides, carbonate esters, C1-C10 ethoxylated and propoxylated alcohols, lactones, pyrrolidones and mixtures thereof. Examples of non-limiting lower alkyl alcohols are monohydric alcohols having 1 to 6 carbons, such as Petition 870250079886, dated 05 / 09 / 2025, page 64 / 204 59 / 97 ethanol and isopropanol. Some non-limiting examples of polyhydric alcohols useful in the present invention include propylene glycol, dipropylene glycol, butylene glycols, hexylene glycol, glycerin, propanediols, and mixtures thereof.

[0148] The personal care composition may comprise a hydrotrope / viscosity modifier that is an alkali metal or ammonium salt of a lower alkyl benzene sulfonate, such as sodium xylene sulfonate, sodium cumene sulfonate or sodium toluene sulfonate.

[0149] The composition for personal care may comprise silicone / PEG-8 silicone / PEG-9 silicone / PEG-n silicone / silicone ether (n could be another whole number), non-limiting examples including PEG8-dimethicone A208), MW 855, PEG 8 dimethicone D208, MW 2706. Active ingredients for scalp, facial / body skin and hair health.

[0150] Scalp, facial / body skin and hair health actives may be a material or a mixture selected from the group consisting of: azoles, such as climbazole, ketoconazole, itraconazole, econazole and elubiol; hydroxypyridones, such as octopirox (piroctone olamine), ciclopirox, rilopirox and MEAhydroxyoctyloxypyridinone; strobilurins, such as azoxystrobin and metal chelators, such as 1,10-phenanthroline, polyvalent metal salts of pyrithione, non-limiting examples include zinc pyrithione Petition 870250079886, dated 05 / 09 / 2025, page 65 / 204 60 / 97 (ZPT - zinc pyrithione) and copper pyrithione, sulfur, selenium sulfide, menthol or menthyl lactate.

[0151] In the present invention, the active ingredient for scalp, facial / body skin and hair health may be an imidazole selected from the group consisting of benzimidazole, benzothiazole, bifonazole, butaconazole nitrate, climbazole, clotrimazole, croconazole, eberconazole, econazole, elubiol, fenticonazole, fluconazole, flutimazole, isoconazole, ketoconazole, lanoconazole, metronidazole, miconazole, neticonazole, omoconazole, oxiconazole nitrate, sertaconazole, sulconazole nitrate, tioconazole, thiazole and mixtures thereof, or the active ingredient for scalp health is a triazole selected from the group consisting of: terconazole, itraconazole and mixtures thereof. The active ingredient for scalp, facial / body skin and hair health may be ketoconazole. Additionally, the only active ingredient for scalp, facial / body skin, and hair health may be ketoconazole.

[0152] The soluble scalp, facial / body skin and hair health active ingredient may be present in an amount of about 0.01% to about 10%, about 0.1% to about 9%, about 0.25% to about 8% and about 0.5% to 6%. The soluble scalp, facial / body skin and hair health active ingredient may be surfactant-soluble and therefore surfactant-soluble scalp, facial / body skin and hair health active ingredient. Petition 870250079886, dated 05 / 09 / 2025, page 66 / 204 61 / 97 Scalp, facial / body skin and hair health agents

[0153] In the present invention, one or more scalp, facial / body skin, and hair health agents can be added to provide scalp, facial / body skin, and hair benefits in addition to the antifungal / anti-dandruff efficacy provided by surfactant-soluble scalp, facial / body skin, and hair health actives. This group of materials is varied and provides a wide range of benefits, including hydration, barrier improvement, antifungal, antimicrobial, and antioxidant action, antipruritic properties, and sensory elements.Such scalp, facial / body skin and hair health agents include, but are not limited to: vitamins E and F, salicylic acid, niacinamide, caffeine, panthenol, zinc oxide, zinc carbonate, basic zinc carbonate, glycols, glycolic acid, PCA, PEGs, erythritol, glycerin, triclosan, lactates, hyaluronates, allantoin, and other ureas, betaines, sorbitol, glutamates, xylitols, menthol, menthyl lactate, isocyclomonone, benzyl alcohol, a compound comprising the following structure:. Petition 870250079886, dated 05 / 09 / 2025, p. 67 / 204 62 / 97 Ri is selected from H, alkyl, amino alkyl, alkoxy; Q = H2, O, -ORi, -N(Ri)2, -OPO(ORi)x, -PO(ORi)x, P(ORi)x, where x = ia 2; V = NRi, O, -OPO(ORi)x, -PO(ORi)x, -P(ORi)x, where x = ia 2; W=H2, O; X, Y = independently selected from H, aryl, naphthyl, for n=0; X, Y = aliphatic CH2 or aromatic CH for n^1 and Z is selected from aliphatic CH2, aromatic CH, or heteroatom; A = lower alkoxy, lower alkylthio, aryl, substituted aryl, or fused aryl; and the stereochemistry is variable at the positions marked with *. and natural extracts / oils including peppermint, spearmint, argan, jojoba and aloe vera. A. Optional ingredients [0i54] In the present invention, the personal care composition may further comprise one or more optional ingredients, including beneficial agents. Suitable beneficial agents include, but are not limited to, conditioning agents, cationic polymers, silicone emulsions, anti-dandruff agents, gel networks, chelating agents, and natural oils such as sunflower oil or castor oil. Additional suitable optional ingredients include, but are not limited to, perfumes, perfume microcapsules, colorants, particles, antimicrobials, and eliminators. Petition 870250079886, dated 05 / 09 / 2025, page 68 / 204 63 / 97 foam, antistatic agents, rheology modifiers and thickeners, suspending and structuring materials, pH adjusting agents and buffers, preservatives, pearlescent agents, solvents, diluents, antioxidants, vitamins and sensory ingredients such as menthol and methyl lactate, and combinations thereof. The composition may contain from about 0.5% to about 7% of a perfume.

[0155] Such optional ingredients must be physically and chemically compatible with the components of the composition and must not otherwise unduly impair the stability, aesthetics, or performance of the product. The CTFA Cosmetic Ingredient Handbook, 10th Edition (published by the Cosmetic, Toiletry, and Fragrance Association, Inc., Washington, DC, USA) (2004) (in this CTFA document), describes a wide variety of non-limiting materials that may be added to the composition of the present composition. 1. Conditioning agents

[0156] The conditioning agent in personal care compositions may be a silicone-based conditioning agent. The silicone-based conditioning agent may comprise volatile silicone, non-volatile silicone, or combinations thereof. The concentration of the silicone-based conditioning agent is typically in the range of about 0.01% to about 10% by weight of the composition, about 0.1% to about 8%, about 0.1% to about 5%, and / or about 0.2% to about 3%. Some non-limiting examples of silicone-based conditioning agents are Petition 870250079886, dated 05 / 09 / 2025, page 69 / 204 Suitable silicones, and optional suspending agents for silicones, are described in the re-granted patent. US Patent No. 34,584 and US Patents No. 5,104,646 and No. 5,106,609, the descriptions of which are incorporated herein by reference.

[0157] The silicone-based conditioning agents for use in the compositions of the present invention may have a viscosity, as measured at 25 °C, of ​​about 20 to about 2,000,000 centistokes (cSt), of about 1,000 to about 1,800,000 cSt, of about 10,000 to about 1,500,000 cSt and of about 20,000 to about 1,500,000 cSt.

[0158] Dispersed silicone-based conditioning agent particles typically have a volume average particle diameter in the range of about 0.01 micrometer to about 60 micrometers. For application of small particles to hair, the volume average particle diameters typically range from about 0.01 micrometer to about 4 micrometers, from about 0.01 micrometer to about 2 micrometers, and from about 0.01 micrometer to about 0.5 micrometers.

[0159] Additional materials on silicones, including sections discussing silicone fluids, gums, and resins, as well as on the manufacture of silicones, are found in Encyclopedia of Polymer Science and Engineering, vol. 15, 2nd ed., pages 204 to 308, John Wiley & Sons, Inc. (1989), incorporated herein by reference.

[0160] Silicone emulsions suitable for use in the present invention include, but are not limited to, Petition 870250079886, dated 05 / 09 / 2025, page 70 / 204 65 / 97 insoluble polysiloxane emulsions. These can be prepared by polymerization of the emulsion, according to the descriptions provided in U.S. Patent No. 6,316,541 or U.S. Patent No. 4,476,282 or U.S. Patent Application Publication No. 2007 / 0276087, or they can be emulsified after polymerization is complete, by means of various emulsification methods as described in U.S. Patent 9,255,184B2 or U.S. Patent 7,683,119 or Emulsions and Emulsion Stability, edited by Johan Sjoblom, CRC Press, 2005. These references can be consulted for a non-limiting list of suitable emulsifiers and emulsifying blends based on the functionality of the silicone used, the emulsification method, and the desired emulsion particle size.Consequently, suitable insoluble polysiloxanes include polysiloxanes, such as alpha, omega hydroxy terminated polysiloxanes or alpha, omega alkoxy terminated polysiloxanes, that have an internal phase viscosity of about 5 cSt to about 500,000 cSt. For example, the insoluble polysiloxane may have an internal phase viscosity of less than 400,000 cSt; less than 200,000 cSt; or from about 10,000 cSt to about 180,000 cSt. The insoluble polysiloxane may have an average particle size in the range of about 10 nm to about 10 microns. The average particle size can be in the range of about 15 nm to about 5 microns, about 20 nm to about 1 micron, or about 25 nm to about 550 nm, or about 1 to 10 microns. The concentration of silicone dispersed in the emulsion can be... Petition 870250079886, dated 05 / 09 / 2025, p. 71 / 204 66 / 97 in the range of about 5 to 90 percent, or 20 to 85 percent, or 30 to 80 percent by weight of the emulsion composition.

[0161] The average molecular weight of the insoluble polysiloxane, the internal phase viscosity of the insoluble polysiloxane, the viscosity of the silicone emulsion, and the particle size comprising the insoluble polysiloxane are determined by methods commonly used by those skilled in the art, such as the methods disclosed in Smith, AL The Analytical Chemistry of Silicones, John Wiley & Sons, Inc.: New York, 1991. For example, the viscosity of the silicone emulsion can be measured at 30 °C with a Brookfield viscometer with a spindle at 2.5 rpm. The silicone emulsion may also contain an additional emulsifier along with the anionic surfactant,

[0162] Other classes of silicones suitable for use in the compositions of the present invention include, but are not limited to: i) silicone fluids, including, but not limited to, silicone oils, which are fluxable materials having a viscosity less than about 1,000,000 cSt, as measured at 25 °C; ii) aminosilicones, which contain at least one primary, secondary or tertiary amine; iii) cationic silicones, which contain at least one quaternary ammonium functional group; iv) silicone gums, which include materials having a viscosity greater than or equal to 1,000,000 cSt, as measured at 25 °C; v) silicone resins, which include highly crosslinked polymeric siloxane systems; vi) silicones with a high viscosity index Petition 870250079886, dated 05 / 09 / 2025, page 72 / 204 67 / 97 refraction, having a refractive index of at least 1.46, and vii) mixtures thereof.

[0163] The conditioning agent of the personal care compositions of the present invention may also comprise at least one organic conditioning material such as oil or wax, either alone or in combination with other conditioning agents, such as the silicones described above. The organic material may be non-polymeric, oligomeric or polymeric. It may be in the form of oil or wax and may be added to the pure composition or in a pre-emulsified form.Some non-limiting examples of organic conditioning materials include, but are not limited to: i) hydrocarbon oils; ii) polyolefins; iii) fatty esters; iv) fluorinated conditioning compounds; v) fatty alcohols; vi) alkyl glycosides and alkyl glycoside derivatives; vii) hydrophobic quaternary ammonium compounds; viii) polyethylene glycols and polypropylene glycols having a molecular weight of up to about 2,000,000, such as those whose CTFA names are PEG-200, PEG-400, PEG-600, PEG-1000, PEG-2M, PEG-7M, PEG-14M, PEG-45M and mixtures thereof. 2. Emulsifiers

[0164] Various anionic and nonionic emulsifiers can be used in the personal care compositions of the present invention. Anionic and nonionic emulsifiers can be monomeric or polymeric in nature. Monomeric examples include, by way of illustration and not limitation, alkyl ethoxylates, alkyl sulfates, soaps, their derivatives, and acids. Petition 870250079886, dated 05 / 09 / 2025, page 73 / 204 68 / 97 and esters. Polymeric examples include, by way of illustration and not limitation, polyacrylates, polyethylene glycols, block copolymers and their derivatives. Naturally occurring emulsifiers such as lanolin, lecithin and lignin and their derivatives are also some non-limiting examples of useful emulsifiers. 3. Chelating agents

[0165] The personal care composition may also comprise a chelating agent. Suitable chelating agents include those listed in AE Martell & RM Smith, Critical Stability Constants, Vol. 1, Plenum Press, New York & London (1974) and AE Martell & RD Hancock, Metal Complexes in Aqueous Solution, Plenum Press, New York & London (1996), both incorporated herein by reference. When relating to chelating agents, the term salts and derivatives thereof means salts and derivatives comprising the same functional structure (e.g., the same chemical structure) as the chelating agent to which they refer and having similar or better chelating properties. This term includes salts of alkali metals, alkaline earth metals, ammonium, substituted ammonium (i.e., monoethanolammonium, diethanolammonium, triethanolammonium), chelating esters with an acidic moiety and mixtures thereof, in particular, all sodium, potassium or ammonium salts.The term derivatives also includes chelating surfactant compounds, such as those exemplified in US patent No. 5,284,972, and large molecules comprising one or more chelating groups that have the same structure. Petition 870250079886, dated 05 / 09 / 2025, page 74 / 204 69 / 97 functional of the original chelating agents, such as polymeric EDDS (ethylenediamine disuccinic acid), described in US patent no. 5,747,440.

[0166] Chelating agents may be incorporated into the compositions of the present invention in amounts ranging from 0.001% to 10.0% by weight of the total composition; from approximately 0.01% to 2.0%.

[0167] The classes of non-limiting chelating agents include carboxylic acids, aminocarboxylic acids, including amino acids, phosphoric acids, phosphonic acids, polyphosphonic acids, polyethylene imines, polyfunctionally substituted aromatics, their derivatives and salts.

[0168] Non-limiting chelating agents include the following materials and their salts. Ethylenediaminetetraacetic acid (EDTA), ethylenediamine triacetic acid, ethylenediamine-N,N'-disuccinic acid (EDDS), ethylenediamine-N,N'-diglutaric acid (EDDG), salicylic acid, aspartic acid, glutamic acid, glycine, malonic acid, histidine, diethylenetriaminepentaacetate (DTPA),Nhydroxyethylethylenediaminetriacetate, nitrilotriacetate, ethylenediaminetetrapropionate, trithylenetetraaminohexaacetate, ethanoldiglycine,propylenediaminetetraacetic acid (PDTA),methylglycinediacetic acid (MODA),diethylenetriaminepentaacetic acid,methylglycinediacetic acid (MGDA), N-acyl-N,N',N'ethylenediaminetriacetic acid, nitrilotriacetic acid, ethylenediaminediglutaric acid (EDGA), acid 2 Petition 870250079886, dated 05 / 09 / 2025, page 75 / 204 70 / 97 hydroxypropylenediamine disuccinic acid (HPDS), glycinamido-N,N'-disuccinic acid (GADS), 2-hydroxypropylenediamino-N,N'-disuccinic acid (HPDDS), N-2-hydroxyethyl-N,N-diacetic acid, glyceriliminodiacetic acid, iminodiacetic acid-N-2-hydroxypropyl sulfonic acid, aspartic acid, N-carboxymethyl-N-2-hydroxypropyl-3-sulfonic acid, alanine-N,N'-diacetic acid, aspartic acid-N,N'-diaceic acid, aspartic acid, N-monoacetic acid, iminodisuccinic acid, diamino-N,N'-dipolyacid, monoamide-N,N'-dipolyacid, diaminoalkyldi(sulfosuccinic) acids (DDS), ethylenediamine-N,N'-bis (ortho-hydroxyphenylacetic acid)), N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, ethylenediaminetetrapropionate, triethylenetetraaminohexacetate, diethylenetriaminepentaacetate, dipicolinic acid, ethylenedicisteic acid (EDC), ethylenediamineN,N'-bis(2-hydroxyphenylacetic acid) (EDDHA), glutamic acid diacetic acid (GLDA), hexadentedaminocarboxylate (HBED), polyethyleneimine,1-hydroxydiphosphonate, aminotri(methylenephosphonic) (ATMP), nitrilotrimethylenephosphonate (NTP), ethylenediaminetetramethylenephosphonate, diethylenetriaminepentamethylenephosphonate (DTPMP), ethane-1-hydroxydiphosphonate (HEDP), 2-phosphonobutane-1,2,4-tricarboxylic acid, polyphosphoric acid, sodium tripolyphosphate, tetrasodium diphosphate, hexametaphosphoric acid, sodium metaphosphate, phosphonic acid and derivatives, acid, Petition 870250079886, dated 05 / 09 / 2025, page 76 / 204 71 / 97 aminoalkylene-poly(alkylenephosphonic), aminotri(1-ethylphosphonic acid), ethylenediaminetetra(1-ethylphosphonic acid), aminotri(1-propylphosphonic acid), aminotri(isopropylphosphonic acid), ethylenediaminetetra(methylenephosphonic) acid (EDTMP), 1,2dihydroxy-3,5-disulfobenzene. water vehicle

[0169] Personal care compositions may be in the form of pourable liquids (under ambient conditions). Therefore, such compositions will typically comprise a vehicle, which is present in a proportion of about 40% to about 85%, alternatively, about 45% to about 80%, alternatively, about 50% to about 75% by weight of the personal care composition. The vehicle may contain water or a miscible mixture of water and organic solvent, and, in one aspect, may comprise water with little or no significant concentration of organic solvent, except when subsequently incorporated into the composition as secondary ingredients of other essential or optional components.

[0170] The vehicle that may be useful in the personal care compositions of the present invention may include water and water solutions of lower alkyl alcohols and polyhydric alcohols. The lower alkyl alcohols useful for the present invention are monohydric alcohols having from 1 to 6 carbons in one aspect, ethanol and isopropanol. Examples of polyhydric alcohols Petition 870250079886, dated 05 / 09 / 2025, page 77 / 204 72 / 97 useful for the present invention include propylene glycol, hexylene glycol, glycerin, and propanediol. G. Product form

[0171] The personal care compositions of the present invention may be presented in typical personal care formulations. They may be in the form of solutions, dispersions, emulsions, powders, talcs, encapsulated forms, spheres, sponges, solid dosage forms, foams, and other application mechanisms. The compositions of the present invention may be hair tonics, leave-in hair products such as treatment and styling products, rinse-out hair products such as shampoos and personal hygiene products, including liquid beard soaps and intimate liquid soaps, and treatment products; and any other form that may be applied to the hair. H. Applicator

[0172] In the present invention, the personal care composition can be dispensed from an applicator for direct dispensing onto the skin under the hair (e.g., scalp, skin under the beard, etc.). Direct dispensing onto the skin under the hair by means of a targeted application applicator enables the deposition of undiluted cleansing agents directly onto areas where cleaning needs are greatest. This also minimizes the risk of eye contact with the cleansing solution.

[0173] The applicator is attached or may be attached to a bottle containing the personal care cleansing composition. The applicator may consist of a base that Petition 870250079886, dated 05 / 09 / 2025, page 78 / 204 73 / 97 retains or extends to a single tip or to a plurality of tips. The tips have openings that may be located at the end, or at any point between the end and the base. These openings allow the product to be dispensed from the bottle and applied directly to the hair and / or the skin under the hair.

[0174] Alternatively, the applicator may also consist of brush-shaped bristles attached to or extending from a base. In this case, the product may be dispensed from the base and the bristles may enable the distribution of the product through a combing or brushing motion.

[0175] The design and materials of the applicator and bristles can be optimized to enable a massage for the skin under the hair (e.g., scalp, beard skin, etc.). In this case, it would be beneficial for the bristle or tooth geometry at the tips to be more rounded, similar to the spherical roller applicator used for eye creams. It may also be beneficial for the materials to be smoother and softer; for example, metallic or metal-like finishes, rubbery materials. Preparation of compositions for personal care

[0176] Compositions for personal care are prepared by adding surfactants, anti-dandruff agents, perfumes, viscosity modifiers, cationic polymers and the remaining water with vigorous stirring to ensure a homogeneous mixture. The mixture may be heated to 50 to 75 °C to accelerate the solubilization of the soluble agents, then cooled. The Petition 870250079886, dated 05 / 09 / 2025, page 79 / 204 74 / 97 The product pH can be adjusted, if necessary, to provide personal care compositions of the present invention that are suitable for application to the scalp, facial / body skin and hair, and can range from about a pH of about 2.5 to about 5.5 or from about 2.5 to about 5, or from about 2.5 to 3.5, or from about pH 3 to 5, and from about 3 to 4, based on the selection of particular detergent surfactants and / or other components. Hydroxy acid cocktail

[0177] Hydroxy Acid Cocktail Selection: A cocktail of hydroxy acids (salicylic and citric) is identified using a first-principles modeling approach. The model leveraged octanol / water hydroxy acid partition coefficients (LogP), acid dissociation constants (pKa), and calcium binding constants (logK) to define the ability of each hydroxy acid to chelate metals from the surface of both hair and skin under the hair, as well as to bind calcium in the upper layers of the skin. The present invention aimed to determine whether any of the hydroxy acids of interest has a driving force to penetrate / partition into a lipid matrix (skin and hair). Based on LogP, salicylic acid has the highest driving force for lipid partitioning while citric acid has low partitioning. The present invention further sought to understand the availability of each hydroxy acid to bind calcium once in its desired phase.Salicylic acid with a carboxylic group shows some ability to bind to... Petition 870250079886, dated 05 / 09 / 2025, pages 80 / 204 75 / 97 calcium within the lipid matrix and citric acid with three carboxylic groups shows a high capacity to bind calcium outside the lipid phase. With these two acids being the supports for penetration into a lipid matrix, as well as the ability to bind calcium, they are selected to be used in combination for product prototyping. Table 2 Dataset used for modeling: Hydroxy acid LogP pKa_1 pKa_2 pKa_3 logK_1 logK_2 logK_3 Acetic acid -0.280 4.756 1.180 Citric acid -1.640 3.128 4.761 6.396 1.100 3.090 4.680 Glyconic acid -1.870 3.600 1.880 Glycolic acid -1.050 3.830 1.590 Lactic acid -0.720 3.860 1.450 Salicylic acid 2.260 2.970 1.100 Tartaric acid -0.760 2.890 4.400 0.920 2.800 Petition 870250079886, dated 05 / 09 / 2025, page 81 / 204 76 / 97 In vitro calcium chelation screening of weak acids:

[0178] A high-throughput in vitro screening method is developed to help identify lead acids that could function as calcium chelators. The intention of the method is to mimic the lipid matrix of the scalp and quantify the amount of calcium that could be extracted from this matrix. A 1000 ppm CaCO3+ solution is prepared in octanol (substitute lipid phase). Water solutions containing 3% hydroxy acid by weight are also prepared (aqueous phase) and adjusted to a pH of approximately 3. Equal parts of the lipid and aqueous phases are added to a conical flask and vortexed for 2 minutes. The flasks are left to stand for 2 hours, and then the lower aqueous phase is extracted from the conical flask and subjected to calcium analysis by inductively coupled plasma optical emission spectroscopy (ICP-OES).The table below describes the amount of calcium present in the aqueous phase after the experimental procedure. % calcium in the aqueous phase = calcium measured in the aqueous phase (ppm) 40^4 1000 ppm of CaCO3 in the lipid phase * ---- m^rt (1002S * 100 Table 3 Hydroxy acid % of calcium in the aqueous phase Petition 870250079886, dated 05 / 09 / 2025, page 82 / 204 77 / 97 Citric acid 79% Lactic acid 78% Glycolic acid 78% Tartaric acid 38% Salicylic acid 29% Water (control) 8%

[0179] Discussion: Citric acid exhibits the highest calcium chelating capacity of the subset of hydroxy acids that is screened. Salicylic acid exhibits the lowest calcium chelating capacity. 1. Formulation parameters to enable the application of salicylic acid: 2a. Deposition on the scalp in vivo

[0180] Scalp deposition of the scalp active ingredient is measured by washing the subjects' hair with a composition comprising a scalp active ingredient, for example, a composition according to the present invention. A trained cosmetic specialist will dose 5 g of the liquid product control onto half of the examiner's scalp and wash according to conventional washing protocol. Then, 5 g of the test product are dosed onto the other half of the examiner's head and washed according to conventional washing protocol. The hair is then parted in one area of ​​the scalp to allow an open glass cylinder to be held over the surface while an aliquot of an extraction solution is added and stirred before recovery and analytical determination of the scalp active ingredient content. Petition 870250079886, dated 05 / 09 / 2025, pages 83 / 204 78 / 97 scalp by conventional methodology, such as high-performance liquid chromatography (HPLC). The scalp deposition method can be used as a substitute method to measure the application of an active ingredient (e.g., salicylic acid) to biological substrates. Active deposition measurement

[0181] The concentration of the agent in the ethanol extraction solvent is measured by HPLC. Quantification is performed by reference to a standard curve. The concentration detected by HPLC is converted to a collected quantity using the concentration in grams multiplied by volume. The deposition efficiency can be calculated using the following equation. The area of ​​the scalp extracted in each case is kept constant:

[0182] Deposition efficiency = mass of agent deposited using the example formula / mass of agent deposited using the control formula

[0183] Sample calculation for deposition efficiency, where: Mass of salicylic acid (SA) deposited using the example formula = 1.0 µg Mass of salicylic acid (SA) deposited using the control formula = 0.5 µg Deposition efficiency = 1.0 / 0.5 Deposition efficiency = 2X Table 4 Example ABC compositions Petition 870250079886, dated 05 / 09 / 2025, page 84 / 204 79 / 97 Sodium lauryl sulfate 1 9.00 9.00 9.00 Sodium laureth sulfate 2 Sodium methyl cocoyl taurate 3 Cocamidopropyl betaine 4 3.75 3.75 3.75 Salicylic acid 5 3.00 3.00 3.00 Citric acid 6 pH adjustment pH adjustment pH adjustment Guar gum hydroxypropyltrimonium chloride 7 0.40 0.40 Polyacrylate-6 crosspolymer 8 Polysorbate 20 9 Sodium benzoate 10 0.25 0.25 0.25 Methylchloroisothiazolinone / methylisothiazolinone 11 5 ppm 5 ppm 5 ppm Tetrasodium EDTA 12 0.16 0.16 0.16 Sodium hydroxide 13 pH adjustment pH adjustment pH adjustment pH Water (qs to 100%) qsqsqs pH 5.5 4.0 5.5 Leave for a while before rinsing (min) 3 3 3 Salicylic acid deposition 1.4 ug / cm2 Control 3.2 ug / cm2 + 1.6 ug / cm2 Petition 870250079886, dated 05 / 09 / 2025, page 85 / 204 80 / 97 *Significantly upward +, parity =, Significantly downward - Deposition efficiency Control 2.3X 1.1X Table 5 Example Compositions DEFGHI Sodium Lauryl Sulfate 1 9.00 Sodium Laureth Sulfate 2 2.50 Sodium Methyl Cocoyl Taurate 3 2.50 2.50 5.00 2.50 Cocamidopropyl Betaine 4 3.75 Salicylic Acid 5 3.00 3.00 3.00 3.00 3.00 3.00 Citric Acid 6 pH Adjustment 2.00 2.00 2.00 2.00 2.00 Guar Gum Hydroxypropyltrimonium Chloride 7 0.40 Polyacrylate-6 Crosspolymer 8 1.75 1.75 1.75 1.75 1.75 Polysorbate 20 9 0.20 0.20 0.20 0.20 0.20 Sodium benzoate 10 0.25 Methylchloroisothiazolinone / methylisothiazolinone 11 5 ppm Tetrasodium EDTA 12 0.16 Sodium hydroxide 13 pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment Petition 870250079886, dated 05 / 09 / 2025, page 86 / 204 81 / 97 Water (qs to 100%) qsqsqsqsqsqs pH 4.0 3.0 3.0 3.0 3.0 3.0 Leave for a while before rinsing (min) 3 3 3 3 3 3 Salicylic acid deposition *Significantly up +, parity =, Significantly down - 3.2 ug / cm2 + 8.5 ug / cm2 + 7.9 ug / cm2 + 7.8 ug / cm2 + 6.8 ug / cm2 + 9.1 ug / cm2 + Deposition efficiency 2.3X 6.1X 5.6X 5.6X 4.9X 6.5X Table 6 Example compositions KLMNOP Sodium lauryl sulfate 1 Sodium laureth sulfate 2 Sodium methyl cocoyl taurate 3 2.50 2.50 2.50 2.50 5.40 9.00 Cocamidopropyl betaine 4 3.00 5.00 Salicylic acid 5 3.00 3.00 3.00 1.00 3.00 3.00 Citric acid 6 2.00 2.00 2.00 2.00 2.00 2.00 Hydroxypropyltrimonium chloride of guar gum 7 Polyacrylate-6 crosspolymer 8 1.75 1.75 1.75 1.75 Polysorbate 20 9 0.20 0.20 0.20 0.20 Sodium benzoate 10 0.25 0.25 Petition 870250079886, dated 05 / 09 / 2025, page 87 / 204 82 / 97 Methylchloroisothiazolinone / methylisothiazolinone 11 Tetrasodium EDTA 12 Sodium hydroxide 13 pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment Water (qs to 100%) qsqsqsqsqsqs pH 3.0 3.0 3.0 3.0 4.0 4.0 Leave for a time before rinsing (min) 3 0 0 0 0 0 Salicylic acid deposition *Significantly up +, parity =, Significantly down - 7.1 ug / cm2 + 4.9 ug / cm2 + 5.5 ug / cm2 + 2.2 ug / cm2 + 2.7 ug / cm2 + 2.1 ug / cm2 Deposition efficiency 5.1X 3.5X 3.9X 1.6X 1.9X 1.5X Conclusions regarding deposition on the scalp: 1. Lower pH allows for greater deposition of salicylic acid on the scalp (A vs. B). 2. Deposition on the scalp is minimally enabled by the application of coacervate (A vs. C). 3. The low pH, low surfactant prototype applied significantly more deposition to the scalp vs. the control (A vs. I). 4. No difference in salicylic acid deposition between sulfate-free (sodium methyl cocoyl taurate) and sulfated (SLE1S) surfactants (E vs. F). Petition 870250079886, dated 05 / 09 / 2025, pages 88 / 204 83 / 97 5. Lower surfactant content allows for greater deposition of salicylic acid on the scalp (I vs. H, Q vs. P). 6. Shorter waiting time before rinsing reduces the amount of salicylic acid deposited on the scalp (L vs. K). 7. Lower salicylic acid content in the product will result in lower levels of salicylic acid being deposited on the scalp (N vs. M).

[0184] The personal care composition of the present invention may have a hydroxy acid deposition efficiency on the scalp of at least 1.5X. The personal care composition of the present invention may have a hydroxy acid deposition efficacy of 6.5X. Table 7 2b. Deposition in hair Example Compositions QR Sodium Lauryl Sulfate 1 9.00 Sodium Laureth Sulfate 2 2.00 Sodium Methyl Cocoyl Taurate 3 Cocamidopropyl Betaine 4 3.75 Salicylic Acid 5 3.00 3.00 Citric Acid 6 pH Adjustment pH Adjustment Guar Gum Hydroxypropyltrimonium Chloride 7 0.10 Polyacrylate-6 Crosspolymer 8 1.75 Petition 870250079886, dated 05 / 09 / 2025, pages 89 / 204 84 / 97 Polysorbate 20 9 0.20 Sodium benzoate 10 0.25 Methylchloroisothiazolinone / methylisothiazolinone 11 5 ppm Tetrasodium EDTA 12 0.16 Sodium hydroxide 13 pH adjustment pH adjustment Fragrance 1.00 Water (qs to 100%) qs qs pH 5.5 3.0 Leave for a time before rinsing (min) 0 min 3 min 5 min 0 min 3 min 5 min Salicylic acid deposition (ppm) 240 699 963 280 1124 1269 % water absorption at 90% RH 22.7 2 22.44 22.3 3 22.48 22.23 22.12 Conclusions regarding deposition in hair: 1. Leaving the product on the hair longer before rinsing allows for greater deposition of salicylic acid in the hair (Q, R). 2. Increased DVS benefit of (R) vs. (Q), which generates an indication that greater application of salicylic acid enables a reduction in water absorption. Table 8 Caption: 1. 2. SLS, 29% asset, supplier: Stepan Company SLE1S, 26% active ingredient, supplier: P&G Chemicals Petition 870250079886, dated 05 / 09 / 2025, pages 90 / 204 85 / 97 3. Pureact Conc., 30% active ingredient, supplier: Innospec 4. Tego Betain L 7 OK, 30% active ingredient, supplier: Evonik 5. Salicylic acid, USP, supplier: Novacyl 6. Anhydrous citric acid, supplier: Archer Daniels Midland 7. Jaguar Excel, supplier: Solvay 8. Sepimax Zen, supplier: Seppic 9. Tween 20-LQ-(AP), supplier: Croda 10. Dense sodium benzoate NF / FCC, supplier: Emerald Performance Materials 11. Kathon CG, 1.5% active ingredient, supplier: Rohm & Haas 12. Dissolvine 220-S, 84% active ingredient, supplier: Akzo Nobel 13. Liquid caustic soda, 50%, supplier: Univar 3. Perception of benefit: 3rd Scalp Benefit - flaking with a comb:

[0185] Example composition I is tested in a small-base (n=28) split-scalp consumer study in which consumers incorporated the composition I continued with my normal routine on one side of my scalp and proceeded with my normal routine on the other side. Examiners are asked to compare their overall results on the treated side vs. the untreated side on a scale of: treated side is MUCH worse (-2), treated side is SLIGHTLY worse (-1), treated side is the same (0), treated side is SLIGHTLY better (+1), treated side is MUCH better (+2). In addition, examiners Petition 870250079886, dated 05 / 09 / 2025, pages 91 / 204 86 / 97 participants completed an activity in which they combed away dry skin scales onto a black sheet of paper on each side of their scalp. These scales were then analyzed using image analysis to quantify the count of dry skin scales, as well as the area of ​​scales per side of the scalp. As shown below, examiners who responded that the treated side was MUCH better also had reduced dry skin scales on the treated side of their scalp. Table 9 Composition I Untreated control side Base size n=28 Scale count 856 s* 1151 Scale area 30471 38565 *s = assessed with a 20% risk Table 10 AVE DELTA (between sides) A ​​little WORSE (-1) EQUAL (0) A LITTLE better (+1) MUCH better (+2) Number of responses 2 5 9 12 COUNT - Ave Delta 149 -25 -293 -484 AREA - Ave Delta 10073 2949 -7744 -15986 3c. Benefits of technical hair

[0186] Method: A small-base split scalp hair harvesting study (n=12) where samples Petition 870250079886, dated 05 / 09 / 2025, pages 92 / 204 87 / 97 hair samples are harvested before and after treatment with sample composition I, as well as after 1 week of use. The examiner is instructed to maintain their normal routine across their head, but to add the test composition (i) as a second step between shampoo and conditioner on one side of their head. Hair samples are collected from both sides to variably compare the impact of adding the test composition (i) to their routine. The metal content in the hair is measured by ICP-OES and the measurements are reported as a % difference vs. baseline metal content in the hair. Table 11 Metallic chelation Control Treatment (I) Metal After 1 wash After 1 week After 1 wash After 1 week Calcium +23.4% +29.1% +6.8% -4.7% Copper +41.8% +56.5% +36.9% +36.0% Iron +3.8% +4.7% -7.3% -6.8% Magnesium +3.6% +2.6% -0.7% -17.6% Zinc +8.6% +4.7% +3.0% -11.8% Discussion on metal chelation: 1. The main metals present in hair at the baseline are calcium, magnesium, and zinc (>200 ug / g of hair). Petition 870250079886, dated 05 / 09 / 2025, pages 93 / 204 88 / 97 2. The addition of the composition in example I allows for a reduction in the metals present in the hair compared to current consumer habits. a. Significant (reduced) difference in Ca after 1 use of the product vs. current habit b. Significant (reduced) difference in Ca, Cu, Fe, Mg, and Zn after 1 week of product use vs. current habit. Non-limiting examples

[0187] The personal care compositions illustrated in the following examples are prepared using conventional formulation and mixing methods. All quantities exemplified are listed as percent by weight on an active basis and exclude minor materials such as diluents, preservatives, color solutions, image ingredients, botanicals, and so forth, except where otherwise specified. All percentages are based on weight, except where otherwise specified. Table 12 Ingredients Example, % by weight of active ingredient 1 2 3 4 5 Sodium lauryl sulfate 1 9.00 Sodium laureth sulfate 2 8.00 Sodium methyl cocoyl taurate 3 5.00 2.50 7.50 Sodium caproyl methyl taurate 4 2.50 Decyl glucoside 5 3.00 2.50 Petition 870250079886, dated 05 / 09 / 2025, pages 94 / 204 89 / 97 Cocamidopropyl betaine 6 3.75 2.00 3.00 Salicylic acid 7 3.00 1.80 3.00 Citric acid 8 2.00 1.00 Lactic acid 9 2.00 Glycolic acid 10 3.00 Tartaric acid 11 1.00 Hydroxypropyltrimonium chloride of guar gum 12 0.10 0.25 0.40 Polyquaternium-10 13 0.40 0.1 Polyacrylate-6 crosspolymer 14 0.50 2.00 Polysorbate 20 15 0.20 Piroctone olamine 16 0.5 Sodium benzoate 17 0.25 0.45 0.1 0.45 0.25 Methyl chloro Isothiazolinone / Methylisothiazolinone 18 5 ppm 5 ppm 5 ppm 5 ppm Tetrasodium EDTA 19 0.13 0.2 0.16 0.13 0.16 Fragrance 1.0 0.1 0.5 1.2 Sodium hydroxide 20 pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment Sodium chloride 21 Up to 3% Up to 3% Up to 3% Up to 3% Up to 3% Water (qs to 100%) qsqsqsqsqs pH 4.00 5.00 5.00 4.50 3.00 Table 13 Ingredients Example, % by weight of active ingredient 6 7 8 9 10 11 12 Sodium lauryl sulfate 1 2.00 Sodium laureth sulfate 2 5.00 Petition 870250079886, dated 05 / 09 / 2025, pages 95 / 204 90 / 97 Sodium methyl cocoyl taurate 3 2.50 5.00 Sodium caproyl methyl taurate 4 3.00 Decyl glucoside 5 1.00 Cocamidopropyl betaine 6 2.00 Sodium lauroamphoacetate 22 5.00 7.00 Sodium trideceth sulfate 23 2.50 1.00 Sodium myristoyl sarcosinate 24 2.50 1.00 Salicylic acid 7 3.00 1.00 2.00 1.80 1.80 Citric acid 8 2.00 2.00 1.60 Lactic acid 9 1.00 2.00 Glycolic acid 10 2.00 Tartaric acid 11 2.00 Guar gum hydroxypropyltrimonium chloride 12 0.10 0.10 0.50 Polyquaternium-10 13 0.40 Polyacrylate-6 crosspolymer 14 1.50 1.75 1.00 2.0 1.75 1.50 Polysorbate 20 15 0.1 0.50 0.20 1.0 Piroctone olamine 16 0.5 Sodium benzoate 17 0.25 0.45 0.15 0.45 0.25 0.45 0.45 Methylchloroisothiazolinone / methylisothiazolinone 18 5 ppm 5 ppm 5 ppm Tetrasodium EDTA 19 0.13 0.20 0.12 0.12 Menthol 25 up to 1% up to 1% Fragrance 1.0 0.1 1.2 0.5 0.50 0.75 Petition 870250079886, dated 05 / 09 / 2025, pages 96 / 204 91 / 97 Sodium hydroxide 20 pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment pH adjustment Sodium chloride 21 Up to 3% Up to 3% Up to 3% Up to 3% Up to 3% Water (qs to 100%) qsqsqsqsqsqsqs pH 4.00 3.50 3.00 2.50 4.50 4.00 4.00 Table 14 1. SLS, 29% active ingredient, supplier: Stepan Company 2. SLE1S, 26% active ingredient, supplier: P&G Chemicals 3. Pureact Conc., 30% active ingredient, supplier: Innospec 4. Diapon HF-SF, 27% active ingredient, supplier: NOF Corporation 5. Plantaren 2000 N UP, 50% active ingredient, supplier: BASF 6. Tego Betain L 7 OK, 30% active ingredient, supplier: Evonik 7. Salicylic acid, USP, supplier: Novacyl 8. Anhydrous citric acid, supplier: Archer Daniels Midland 9. Lactic acid, 90%, supplier: P&G 10. Glycolic acid, 70%, supplier: Dupont Chemical 11. Fine granular tartaric acid, supplier: American Tartaric Products INC. 12. Jaguar Excel, supplier: Solvay 13. UCARE LR-30M Polymer, supplier: Dow Chemical 14. Sepimax Zen, supplier: Seppic 15. Tween 20-LQ-(AP), supplier: Croda 16. Piroctone Olamine, supplier: Clariant Petition 870250079886, dated 05 / 09 / 2025, pages 97 / 204 92 / 97 17. Dense sodium benzoate NF / FCC, supplier: Emerald Performance Materials 18. Kathon CG, 1.5% active ingredient, supplier: Rohm & Haas 19. Dissolvine 220-S, 84% active ingredient, supplier: Akzo Nobel 20. Liquid caustic soda, 50%, supplier: Univar 21. Sodium chloride, supplier: Morton; adjustable level to achieve target viscosity 22. Miranol Ultra 32, supplier: Rhodia 23. Rhodapex Est-30, 30% active ingredient, supplier: Rhodia 24. Hamposyl M-30, 30% active ingredient, supplier: Croda 25. Menthol, supplier: Kerry Additional examples / combinations

[0188] A. A composition for personal care comprising: from 2% to 10% of an anionic surfactant; 0.5% to 5% of a hydroxy acid selected from the group consisting of salicylic acid in combination with citric acid; the personal hygiene composition having a pH of about 2.5 to about 5.5.

[0189] B. A personal care composition, according to paragraph A, having a hydroxy acid deposition efficiency on the scalp of at least 1.5X.

[0190] C. A composition for personal care, according to paragraphs A to B, having a hydroxy acid deposition efficacy of 6.5X.

[0191] D. A composition for personal care, according to paragraphs A to C, wherein the surfactant is Petition 870250079886, dated 05 / 09 / 2025, pages 98 / 204 93 / 97 selected from the group consisting of anionic, amphoteric, nonionic or zwitterionic surfactants, or mixtures thereof.

[0192] E. A composition for personal care, according to paragraphs A to D, additionally comprising from about 0.25% to about 8% of one or more amphoteric, nonionic or zwitterionic co-surfactants.

[0193] F. A composition for personal care, according to paragraphs A to E, wherein the pH is about 3 to about 4.

[0194] G. A composition for personal care, according to paragraphs A to F, wherein the hydroxy acid is present in about 1% to about 4%.

[0195] H. A composition for personal care, according to paragraphs A to G, wherein the hydroxy acid is present in about 2% to about 3%.

[0196] I. A composition for personal care, according to paragraphs A to H, wherein the anionic surfactant is present in about 2% to about 8%.

[0197] J. A composition for personal care, according to paragraphs A to I, wherein the composition additionally comprises a polymer.

[0198] K. A composition for personal care, according to paragraphs A to J, wherein the composition further comprises a cationic polymer.

[0199] L. A composition for personal care, according to paragraphs A to K, further comprising one or more cationic polymers selected from the group Petition 870250079886, dated 05 / 09 / 2025, pages 99 / 204 94 / 97 consisting of a cationic guar gum polymer, a non-guar galactomannan cationic polymer, a tapioca cationic polymer, a cationic copolymer of acrylamide monomers and cationic monomers, a synthetic, non-crosslinked, cationic polymer, which may or may not form lyotropic liquid crystals upon combination with the detergent surfactant, a cellulose cationic polymer and mixtures thereof.

[0200] M. A composition for personal care, according to paragraphs A to L, wherein one or more cationic polymers are selected from the group consisting of hydroxypropyltrimonium chloride of guar gum, hydroxyethyl cellulose salts reacted with trimethylammonium substituted epoxide, a cationic copolymer of acrylamide monomers and cationic monomers, a synthetic, non-crosslinked cationic polymer, which may or may not form lyotropic liquid crystals upon combination with the detergent surfactant.

[0201] N. A composition for personal care, according to paragraphs A to M, wherein one or more cationic polymers are present from about 0.08% to about 3%.

[0202] O. A composition for personal care, according to paragraphs A to N, wherein one or more cationic polymers are present from about 0.1% to about 2%.

[0203] P. A personal care composition, in accordance with paragraphs A to O, wherein one or more Petition 870250079886, dated 05 / 09 / 2025, pages 100 / 204 95 / 97 Cationic polymers are present from about 0.2% to about 1%.

[0204] Q. A composition for personal care, according to paragraphs A to P, additionally comprising from about 0.01% to about 10% of one or more thickening polymers.

[0205] R. A composition for personal care, according to paragraphs A to Q, wherein one or more thickening polymers are selected from the group consisting of homopolymers based on acrylic acid, methacrylic acid or other related derivatives, alkali expandable and hydrophobically modified alkali expandable acrylic copolymers or methacrylate copolymers, soluble crosslinked acrylic polymers, associative polymeric thickeners and mixtures thereof.

[0206] S. A personal care composition, according to paragraphs A to R, which additionally includes one or more active ingredients for scalp, facial / body skin or hair health.

[0207] T. A composition for personal care, according to paragraphs A to S, wherein one or more active ingredients for scalp, facial / body skin or hair health are selected from the group consisting of polyvalent metal salts of pyrithione, piroctone olamine, climbazole, sulfur, menthol, menthyl lactate and mixtures thereof.

[0208] U. A personal care composition, in accordance with paragraphs A to T, wherein one or more active ingredients Petition 870250079886, dated 05 / 09 / 2025, pages 101 / 204 96 / 97 scalp, facial / body skin or hair health are piroctone olamine.

[0209] V. A composition for personal care, according to paragraphs A to U, wherein one or more of the active ingredients for scalp, facial / body skin or hair health are zinc pyrithione.

[0210] W. A composition for personal care, according to paragraphs A to W, wherein one or more active ingredients for scalp, facial / body skin or hair health are present from about 0.01% to 10%.

[0211] X. A personal care composition, in accordance with paragraphs A to X, which additionally comprises one or more scalp, facial / body skin or hair health agents.

[0212] Y. A composition for personal care, according to paragraphs A to Y, wherein the scalp, facial / body skin or hair health agent is present in about 0.05% to 9%.

[0213] Z. A personal care composition, according to paragraphs A to Z, wherein one or more scalp, facial / body skin or hair health agents are present in amounts of approximately 0.1% to 8%.

[0214] The dimensions and values ​​disclosed herein should not be understood as strictly limited to the exact numerical values ​​mentioned. Instead, except where otherwise specified, each of these dimensions is intended to mean both the value mentioned and a range of functionally equivalent values. Petition 870250079886, dated 05 / 09 / 2025, pages 102 / 204 97 / 97 around that value. For example, a dimension revealed as 40 mm should mean approximately 40 mm.

[0215] Each document cited in the present invention, including any patent or patent application referenced or related, and any patent application or patent in which the present application claims priority or benefit thereof, is incorporated herein by reference, except where expressly excluded or otherwise limited. Mention of any document is not an admission that it constitutes prior art relating to any invention disclosed or claimed in the present invention, or that it alone, or in any combination with any other reference or references, teaches, suggests or reveals any such invention. Furthermore, if there is a conflict between any meaning or definition of a term in this document and any meaning or definition of the same term in a document incorporated by reference, the meaning or definition ascribed to that term in this document shall prevail.

[0216] Although specific embodiments of the present invention have been illustrated and described, it will be evident to those skilled in the art that various other alterations and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended that the appended claims encompass all such alterations and modifications that are within the scope of the present invention. Petition 870250079886, dated 05 / 09 / 2025, pp. 103 / 204

Claims

1 / 4 CLAIMS 1. Personal care composition characterized by comprising: a. 2% to 10% of an anionic surfactant; b. 0.5% to 5% of a hydroxy acid selected from the group consisting of salicylic acid in combination with citric acid; wherein the personal care composition has a pH of 2.5 to 5.

5.

2. A personal care composition, according to any of the preceding claims, characterized by having a hydroxy acid deposition efficiency on the scalp of at least 1.5X, preferably having a hydroxy acid deposition efficacy of 6.5X.

3. Personal care composition, according to any of the preceding claims, characterized in that the surfactant is selected from the group consisting of anionic, amphoteric, nonionic or zwitterionic surfactants, or mixtures thereof.

4. Personal care composition, according to any of the preceding claims, characterized by additionally comprising from 0.25% to 8% of one or more amphoteric, non-ionic or zwitterionic co-surfactants.

5. Personal care composition, according to any of the preceding claims, characterized by a pH of 3 to 4.

6. Personal care composition, according to any of the preceding claims, characterized in that the hydroxy acid is present from 1% to 4%, preferably from 2% to 3%. Petition 870250079886, dated 05 / 09 / 2025, pp. 196 / 204 2 / 4 7. Personal care composition, according to any of the preceding claims, characterized in that the anionic surfactant is present from 2% to 8%.

8. Personal care composition, according to any of the preceding claims, the composition being characterized by additionally comprising a polymer.

9. A composition for personal care, according to any of the preceding claims, the composition being characterized by further comprising a cationic polymer, preferably comprising one or more cationic polymers selected from the group consisting of a guar gum cationic polymer, a non-guar galactomannan cationic polymer, a tapioca cationic polymer, a cationic copolymer of acrylamide monomers and cationic monomers, a synthetic, non-crosslinked cationic polymer, which may or may not form lyotropic liquid crystals upon combination with the detergent surfactant, a cellulose cationic polymer and mixtures thereof, preferably the one or more cationic polymers being selected from the group consisting of guar gum hydroxypropyltrimonium chloride, epoxide-reacted hydroxyethyl cellulose salts substituted with trimethylammonium, a cationic copolymer of acrylamide monomers and cationic monomers,A synthetic, non-crosslinked, cationic polymer that may or may not form lyotropic liquid crystals upon combination with a detergent surfactant.

10. Personal care composition, according to any of the preceding claims, characterized by one or more cationic polymers being present from 0.08% to 3%, preferably one or more cationic polymers being present from 0.1% to 2%, preferably one or more cationic polymers being present from 0.2% to 1%.

11. A composition for personal care, according to any of the preceding claims, characterized by further comprising from 0.01% to 10% of one or more thickening polymers, preferably the one or more thickening polymers being selected from the group consisting of homopolymers based on acrylic acid, methacrylic acid or other related derivatives, alkali-expandable and hydrophobically modified alkali-expandable acrylic copolymers or methacrylate copolymers, soluble crosslinked acrylic polymers, associative polymeric thickeners and mixtures thereof.

12. Personal care composition, according to any of the preceding claims, characterized by further comprising one or more active ingredients for scalp, facial / body skin or hair health, preferably one or more of these active ingredients are selected from the group consisting of polyvalent metal salts of pyrithione, piroctone olamine, climbazole, sulfur, menthol, menthyl lactate and mixtures thereof, preferably one or more of these active ingredients are piroctone olamine, preferably one or more of these active ingredients are zinc pyrithione. Petition 870250079886, dated 05 / 09 / 2025, pp. 198 / 204 4 / 4 13. Personal care composition, according to any of the preceding claims, characterized by one or more active ingredients for scalp, facial / body skin or hair health being present from 0.01% to 10%.

14. Personal care composition, according to any of the preceding claims, characterized by additionally comprising one or more scalp, facial / body skin or hair health agents.

15. Personal care composition, according to claim 24, characterized in that the scalp, facial / body skin or hair health agent is present from 0.05% to 9%, preferably with one or more scalp, facial / body skin or hair health agents present from 0.1% to 8%. Petition 870250079886, dated 05 / 09 / 2025, pp. 199 / 204