An external-use ointment for treating cervicitis and its preparation method

Abstract

The present invention relates to the technical field of traditional Chinese medicine, and in particular to a composition for treating cervicitis, comprising the following raw materials in parts by weight: 40-50 parts of euphorbia pulex root, 30-40 parts of groundsel, and 10-20 parts of white wormwood. The composition for treating cervicitis of the present invention is composed of euphorbia pulex root, groundsel, and white wormwood, and combines the anti-inflammatory and detoxifying effects of euphorbia pulex root with the heat-clearing and detoxifying effects of groundsel, as well as the sore-healing and pain-relieving effects. The combined use of the various prescriptions of the present invention interacts with each other, and has strong heat-clearing and detoxifying, antibacterial and anti-inflammatory, analgesic, damp-removing, and necrotizing effects, thereby having a good therapeutic effect on cervicitis. Mulberry branches have the effects of promoting blood circulation, removing blood stasis, eliminating edema, and relieving itching. After adding a small amount of mulberry branches, the effect of treating cervicitis is further improved, and the therapeutic effect is significant.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a composition and an ointment for treating cervicitis and a preparation method thereof. Background Art

[0002] Cervicitis is a common and frequently occurring gynecological condition. It is an inflammation of the cervix caused by pathogens and other pathogenic factors. Clinically, cervicitis is categorized into acute and chronic cervicitis, with chronic cervicitis being the most common. Acute cervicitis is an infectious disease of the cervical mucosa and submucosal tissues, extending from the external os of the uterus to the internal os of the cervix. Symptoms of acute cervicitis include cervical redness and swelling, edema of the endocervical mucosa, and increased vaginal discharge that may be mucopurulent or bloody. Irritation from the discharge may cause vulvar itching and burning. If acute cervicitis is not promptly diagnosed and treated, and if the pathogen persists, it can lead to chronic cervicitis. Chronic cervicitis is often caused by pathogens such as Staphylococcus, Streptococcus, and anaerobic bacteria. Gynecological examinations of patients with chronic cervicitis may reveal cervical erosions, yellow discharge covering or leaking from the cervical os, or cervical polyps or cervical hypertrophy.

[0003] Cervicitis seriously harms women's health. During the reproductive period, chronic cervicitis can impair sperm entry into the uterine cavity, leading to infertility. Furthermore, women with cervicitis are ten times more likely to develop cervical cancer, ranking first among gynecological malignancies and second in mortality. Therefore, the prevention, diagnosis, and treatment of cervicitis are crucial for improving women's health and quality of life. Currently, cervicitis and cervical erosion are mainly treated with drugs and physical methods. Drug treatment mainly uses Western medicine preparations. Although it has certain efficacy, it has large side effects, low patient compliance, and is prone to recurrence. Physical therapy is an effective treatment method commonly used in clinical practice, including laser, freezing, electric ironing, microwave, etc., which mainly causes necrosis and shedding of the eroded area, and the original columnar epithelium is covered by new epithelium. Although physical therapy can cause the inflammatory tissue to fall off and the cervical mucosa to be regenerated and repaired, it is prone to some side effects after treatment, such as long vaginal discharge time, bleeding during the descabbing period, difficulty in recovering from the trauma, damage to the muscle tissue structure, serious damage to the autoimmune system, easy recurrence, and even infertility. A variety of traditional Chinese medicine compositions for treating cervicitis are currently disclosed. They use traditional Chinese medicine external treatment methods to directly act on the affected area, achieving good therapeutic effects, with the beneficial effects of no surgery, no trauma, and few side effects. However, these drugs still have the disadvantages of strong medicinal smell, slow effect, poor therapeutic effect, and the possibility of recurrence. Existing drugs do not take into account the impact on the cervix and vaginal environment. Under normal circumstances, the cervix and vagina are weakly acidic environments. If the weakly acidic environment is destroyed, it is easy for bacteria to grow and cause recurrence of cervicitis. Summary of the Invention

[0004] The object of the present invention is to provide a composition, an ointment and a preparation method thereof for treating cervicitis, which overcome the deficiencies and defects mentioned in the background art.

[0005] To achieve the above object, the present invention provides a composition for treating cervicitis, comprising the following raw materials in parts by weight: 40-50 parts of euphorbia pulex roots, 30-40 parts of senecio herba, and 10-20 parts of artemisia annua.

[0006] Preferably, the composition for treating cervicitis further comprises 2 to 8 parts by weight of mulberry branches.

[0007] Preferably, the composition for treating cervicitis is composed of the following raw materials in parts by weight: 45 parts of angelica root, 35 parts of Senecio chinensis, 15 parts of Artemisia annua, and 5 parts of mulberry branches.

[0008] In the composition for treating cervicitis of the present invention, it has been found through research that the root of August melon has a good effect on chronic inflammation and has a unique effect on gynecological inflammation and erosion. The root of August melon has the effects of anti-inflammatory and detoxification, diuresis and swelling reduction, qi and blood circulation, kidney and essence nourishing, etc., and is the main medicine; Senecio has the effects of clearing away heat and detoxification, astringing sores and relieving pain, etc., and is the minister medicine; Artemisia annua has the effects of clearing heat and dampness, cooling blood, etc.; Morus alba has the effects of promoting blood circulation and removing blood stasis, dispelling wind and unblocking meridians, and promoting the circulation of qi and blood, and plays the role of a medicine guide in this prescription; the above four Chinese medicines are combined, and the components cooperate with each other and promote synergistically, and are used to treat cervicitis, with the advantages of significant efficacy, quick effect, and no recurrence.

[0009] The present invention also provides an ointment for treating cervicitis, which is prepared from the above-mentioned composition for treating cervicitis.

[0010] The present invention also provides a method for preparing the above-mentioned ointment for treating cervicitis, comprising the following steps:

[0011] (1) Weighing Senecio radix and Artemisia annua by weight, adding 4 to 8 times the amount of water for the first time and boiling for 1 hour, adding 4 to 8 times the amount of water for the second time, boiling for 1 hour, combining the filtrates, and concentrating the filtrates to a relative density of 1.2 to 1.3 to obtain extract A;

[0012] (2) Weigh the roots of the Chinese wax gourd by weight and decoct them twice, adding 4 to 8 times the amount of water each time and decocting for 1 hour. Combine the filtrates and concentrate the filtrates to a relative density of 1.1 to 1.18 to obtain extract B.

[0013] (3) The extract A and the extract B are mixed evenly to obtain an ointment for treating cervicitis.

[0014] Preferably, in the preparation method of the above-mentioned ointment for treating cervicitis, in the step (1), the mulberry branches are fried until yellow, and then the fried mulberry branches, Senecio radix and Artemisia annua are weighed by weight, 4 to 8 times of water are added for the first time and decocted for 1 hour, and 4 to 8 times of water are added for the second time and decocted for 1 hour, the filtrates are combined, and the filtrates are concentrated to a relative density of 1.2 to 1.3 to obtain extract A.

[0015] Preferably, in the preparation method of the above-mentioned ointment for treating cervicitis, in the step (1), 6 times of water are added for the first time and 6 times of water are added for the second time, and the filtrate is concentrated to a relative density of 1.25; in the step (2), 6 times of water are added each time and boiled for 1 hour, and the filtrate is concentrated to a relative density of 1.15.

[0016] Preferably, in the above-mentioned method for preparing the ointment for treating cervicitis, in step (3), an appropriate amount of auxiliary materials is added to the mixed extract to prepare the ointment.

[0017] Compared with the existing technology, the present invention has the following beneficial effects:

[0018] 1. The composition for treating cervicitis of the present invention is composed of the root of Glechoma longituba, Senecio chinensis, and Artemisia annua. It combines the anti-inflammatory and detoxifying effects of the root of Glechoma longituba with the heat-clearing and detoxifying effects of Senecio chinensis, as well as the sore-healing and pain-relieving effects. The combined effects of the present invention have strong heat-clearing and detoxifying, antibacterial and anti-inflammatory, analgesic, dampness-removing, and new-removing effects, and is significantly effective in treating cervicitis. Mulberry branches have the effects of promoting blood circulation, removing stasis, reducing edema, and relieving itching. The addition of a small amount of mulberry branches further enhances the therapeutic effect of cervicitis.

[0019] 2. The present invention prepares an ointment for treating cervicitis from the roots of Glechoma longituba, Senecio radix, Artemisia annua, and Morus alba. It acts directly on the affected area through the epidermis and has the advantages of rapid onset, good efficacy, and no recurrence after recovery. The ointment does not contain ingredients such as hormones, metals, and antibiotics, and is non-irritating to the skin, mucous membranes, or wound surfaces, with no toxic side effects. The ointment is weakly acidic, consistent with the pH of the vagina and cervix, and does not affect the acid-base balance of the vagina. It can reduce bacterial infection after treatment and prevent recurrence after recovery. DETAILED DESCRIPTION

[0020] The specific embodiments of the present invention are described in detail below, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0021] Example 1

[0022] A paste for treating cervicitis is prepared from the following raw materials in parts by weight: 45 parts of euphorbia pulex roots, 35 parts of senecio herba, and 15 parts of white wormwood.

[0023] A method for preparing an ointment for treating cervicitis comprises the following steps:

[0024] (1) Weigh Senecio radix and Artemisia annua by weight, add 6 times the amount of water for the first time and boil for 1 hour, add 6 times the amount of water for the second time, and boil for 1 hour, combine the two filtrates, and concentrate the filtrates to a relative density of 1.25 to obtain extract A;

[0025] (2) Weigh the roots of the Chinese calamus by weight and decoct them twice, adding 6 times the amount of water each time and decocting for 1 hour. Combine the two filtrates and concentrate the filtrates to a relative density of 1.15 to obtain extract B.

[0026] (3) The extract A and the extract B are mixed evenly to obtain an ointment for treating cervicitis.

[0027] Example 2

[0028] A paste for treating cervicitis is prepared from the following raw materials in parts by weight: 45 parts of euphorbia pulex roots, 35 parts of Senecio chinensis, 15 parts of Artemisia annua and 5 parts of mulberry branches.

[0029] A method for preparing an ointment for treating cervicitis comprises the following steps:

[0030] (1) Fry the mulberry branches until they turn yellow, then weigh the fried mulberry branches, Senecio radix, and Artemisia annua by weight, add 6 times the amount of water for the first time and boil for 1 hour, then add 6 times the amount of water for the second time and boil for 1 hour, combine the two filtrates, and concentrate the filtrates to a relative density of 1.25 to obtain extract A;

[0031] (2) Weigh the roots of the Chinese calamus by weight and decoct them twice, adding 6 times the amount of water each time and decocting for 1 hour. Combine the two filtrates and concentrate the filtrates to a relative density of 1.15 to obtain extract B.

[0032] (3) The extract A and the extract B are mixed evenly to obtain an ointment for treating cervicitis.

[0033] Weigh 5 g of the ointment to the nearest 0.01 g, place it in a beaker, add 20 mL of pre-boiled and cooled distilled water, stir thoroughly, and measure the pH at 20°C using a pH meter (with an accuracy of 0.01 pH unit). Read the indicated value within 10 minutes. Perform four replicate measurements and take the arithmetic mean of the pH values from the four replicates as the measurement result. The pH of the ointment of this example was measured to be 4.52.

[0034] Example 3

[0035] A paste for treating cervicitis is prepared from the following raw materials in parts by weight: 42 parts of radix aconiti Lateralis Preparata roots, 37 parts of senecio radix, 16 parts of white wormwood, and 5 parts of mulberry branches. The preparation method is the same as that of Example 1.

[0036] Example 4

[0037] A paste for treating cervicitis is prepared from the following raw materials in parts by weight: 41 parts of radix aconitifolia roots, 38 parts of senecio radix, 15 parts of white wormwood, and 3 parts of mulberry branches. The preparation method is the same as that of Example 1.

[0038] Example 5

[0039] A paste for treating cervicitis is prepared from the following raw materials in parts by weight: 48 parts of radix schoenoprasum roots, 32 parts of senecio herba, 13 parts of white wormwood, and 4 parts of mulberry branches. The preparation method is the same as that of Example 1.

[0040] Comparative Example 1

[0041] A paste for treating cervicitis is prepared from the following raw materials in parts by weight: 35 parts of Senecio herba, 15 parts of Artemisia annua, and 5 parts of Morus alba. The preparation method is the same as that of Example 1.

[0042] Comparative Example 2

[0043] An ointment for treating cervicitis is prepared from the roots of the wax gourd, and the preparation method is the same as that of Example 1.

[0044] Test Example 1 Clinical trial for the treatment of cervicitis (cervical erosion)

[0045] The clinical treatment effect test of the ointment for treating cervicitis of the present invention on chronic cervicitis was commissioned to be conducted by the Department of Obstetrics and Gynecology of the Eighth People's Hospital of Nanning City.

[0046] 1. Clinical data

[0047] All 160 patients were outpatients aged 25 to 47 years. All patients were free of major organ and coagulation disorders, acute genital tract inflammation, and had not received other medications or physical treatments within 3 months.

[0048] 2. Diagnostic criteria

[0049] According to the area of erosion, it is divided into three degrees: mild (grade I) erosion: the area of cervical erosion accounts for less than 1 / 3 of the cervical area; moderate (grade II) erosion: the area of cervical erosion accounts for 1 / 3-2 / 3 of the cervical area; severe (grade III) erosion: the area of cervical erosion exceeds 2 / 3 of the cervical area.

[0050] The degree of cervical erosion before treatment: 77 cases had grade I erosion, 51 cases had grade II erosion, and 32 cases had grade III erosion.

[0051] 3. Treatment Methods

[0052] The patients were randomly divided into four groups: Example 1 group, Example 2 group, Comparative Example 1 group and Comparative Example 2 group. Age and cervical erosion were used as grouping criteria. There was no significant difference among the four groups, and the groups were comparable.

[0053] Use the cervical buckle (patent number 201822176294.X) for external administration. Apply 5 grams of ointment to the concave surface and column of the buckle. Clean the entire vagina including the cervix. Then place the buckle with the ointment on the cervix, making it fit perfectly with the cervical surface. Remove it after 24 hours and place the medicine for the second time according to the first operation. The buckle is disposable and needs to be replaced with a new buckle each time it is administered. Subsequent administration should be done in the same way. For grade I erosion, the medicine should be used three times in a row, for grade II erosion, the medicine should be used five times in a row, and for grade III erosion, the medicine should be used nine times in a row. The results of the examination and statistics will be conducted on all patients on the fifth day after the end of the medication.

[0054] 4. Criteria for determining efficacy

[0055] Cure: Symptoms completely disappear, erosion surface disappears, and the cervical surface becomes smooth;

[0056] Markedly effective: original symptoms completely disappear or are significantly alleviated, and the erosion surface is reduced by 50% or more;

[0057] Effective: Symptoms are alleviated for those with symptoms, and the erosion area is reduced by less than 50% compared with the previous period;

[0058] Ineffective: There was no change in the erosion area and symptoms before and after treatment.

[0059] 5. Treatment effect

[0060] Comparison of efficacy

[0061] The results of Example 1 group are as follows: 22 cases (55%) were cured, 6 cases (15%) were markedly effective, 7 cases (17.5%) were effective, 5 cases (12.5%) were ineffective, and the total effective rate was 87.5%;

[0062] The results of Example 2 group are as follows: 35 cases (87.5%) were cured, 4 cases (10%) were markedly effective, 1 case (2.5%) was effective, and 0 cases (0%) were ineffective, with a total effective rate of 100%;

[0063] The results of comparative example 1 are as follows: 14 cases (35%) were cured, 6 cases (15%) were markedly effective, 9 cases (22.5%) were effective, 11 cases (27.5%) were ineffective, and the total effective rate was 72.5%;

[0064] The results of the comparative example 2 group were as follows: 12 cases were cured (30%), 5 cases were markedly effective (12.5%), 8 cases were effective (20%), 15 cases were ineffective (37.5%), and the total effective rate was 60%;

[0065] The comprehensive therapeutic effects of cervicitis in the four groups of patients after treatment are shown in Table 1, and the comparison of the therapeutic effects of the four groups of patients with different degrees of erosion after treatment is shown in Table 2. As can be seen from the table, the cure rate and the total effective rate of the example group are significantly higher than those of the comparative example group, and the addition of mulberry branches significantly improves the efficacy of the drug. After treatment, the cure rate reaches 87.5% and the total effective rate reaches 100%.

[0066] Table 1 Comprehensive efficacy of cervicitis in four groups of patients after treatment

[0067]

[0068]

[0069] Table 2 Comparison of therapeutic effects of four groups of patients with different degrees of erosion after treatment

[0070] Group Degree of erosion Number of cases cure Significantly effective efficient invalid Total effective rate (%) Example 1 group I degree 19 12 3 3 1 94.74 II degree 13 6 2 3 2 84.62 III degree 8 4 1 1 2 75.00 Example 2 group I degree 19 18 1 0 0 100.00 II degree 13 11 2 0 0 100.00 III degree 8 6 1 1 0 100.00 Comparative Example 1 I degree 19 9 2 4 4 78.95 II degree 13 5 2 2 4 69.23 III degree 8 0 2 3 3 62.50 Comparative Example 2 I degree 20 9 3 2 6 70.00 II degree 12 3 1 3 5 58.33 III degree 8 0 1 3 4 50.00

[0071] All patients in the treatment group had stable vital signs and no serious adverse reactions such as allergies during the treatment process. After the treatment, the patients in the treatment group were followed up for 3 months without obvious abnormal reactions such as allergies. No recurrence was observed in the patients in Example 1 and Example 2 groups who were cured after half a year of follow-up, indicating that the clinical application of this prescription is safe and effective, and worthy of further research and promotion and application.

[0072] The foregoing descriptions of specific exemplary embodiments of the present invention are for purposes of illustration and description. These descriptions are not intended to limit the invention to the precise forms disclosed, and it is apparent that many modifications and variations are possible in light of the foregoing teachings. The exemplary embodiments have been selected and described for the purpose of explaining the specific principles of the invention and their practical application, thereby enabling those skilled in the art to make and utilize a variety of exemplary embodiments of the invention and various options and variations. The scope of the invention is intended to be defined by the claims and their equivalents.

Claims

1. An external ointment for treating cervicitis, characterized in that: The invention comprises the following raw materials in parts by weight: 40-50 parts of wax gourd roots, 30-40 parts of groundsel and 10-20 parts of white wormwood.

2. The external ointment for treating cervicitis according to claim 1, characterized in that It also includes 2 to 8 parts by weight of mulberry branches.

3. The external ointment for treating cervicitis according to claim 2, characterized in that The invention is composed of the following raw materials in parts by weight: 45 parts of roots of wax gourd, 35 parts of groundsel, 15 parts of white wormwood and 5 parts of mulberry branches.

4. A method for preparing the external ointment for treating cervicitis according to claim 1, characterized in that: The following steps are involved: (1) Weighing Senecio radix and Artemisia annua by weight, adding 4 to 8 times the amount of water for the first time and boiling for 1 hour, adding 4 to 8 times the amount of water for the second time, boiling for 1 hour, combining the filtrates, and concentrating the filtrates to a relative density of 1.2 to 1.3 to obtain extract A; (2) Weigh the roots of the Chinese wax gourd by weight and decoct them twice, adding 4 to 8 times the amount of water each time and decocting for 1 hour. Combine the filtrates and concentrate the filtrates to a relative density of 1.1 to 1.18 to obtain extract B. (3) The extract A and the extract B are mixed evenly to obtain an ointment for treating cervicitis.

5. A method for preparing the external ointment for treating cervicitis according to claim 2 or 3, characterized in that: The following steps are involved: (1) Fry the mulberry branches until they turn yellow, then weigh the fried mulberry branches, Senecio radix, and Artemisia annua by weight, add 4 to 8 times the amount of water for the first time and boil for 1 hour, then add 4 to 8 times the amount of water for the second time and boil for 1 hour, combine the filtrates, and concentrate the filtrates to a relative density of 1.2 to 1.3 to obtain extract A; (2) Weigh the roots of the Chinese wax gourd by weight and decoct them twice, adding 4 to 8 times the amount of water each time and decocting for 1 hour. Combine the filtrates and concentrate the filtrates to a relative density of 1.1 to 1.18 to obtain extract B. (3) The extract A and the extract B are mixed evenly to obtain an ointment for treating cervicitis.

6. The method for preparing the external ointment for treating cervicitis according to claim 4 or 5, characterized in that: In the step (1), 6 times of water is added for the first time and 6 times of water is added for the second time, and the filtrate is concentrated to a relative density of 1.25; in the step (2), 6 times of water is added each time and boiled for 1 hour, and the filtrate is concentrated to a relative density of 1.

15.

7. The method for preparing the external ointment for treating cervicitis according to claim 4 or 5, characterized in that: In the step (3), an appropriate amount of auxiliary materials is added to the mixed extract to prepare an ointment.

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