A Chinese medicine composition for improving male impotence and premature ejaculation and its application

Abstract

The present application relates to a Chinese medicine composition for improving male impotence and premature ejaculation and its application, and relates to the technical field of Chinese medicine. The Chinese medicine composition for improving male impotence and premature ejaculation includes the following raw materials by weight: 100-200 parts of Ligusticum chuanxiong, 80-150 parts of Radix Achyranthis Bidentatae, 20-40 parts of Rhodiola rosea, 1-10 parts of Ginseng, 1-10 parts of Epimedium, 1-10 parts of Morus alba and 1-5 parts of Semen Lepidii. The Chinese medicine composition provided by the present invention uses Ligusticum chuanxiong and Radix Achyranthis Bidentatae as the main effective raw materials and is supplemented with a small amount of Rhodiola rosea, Ginseng, Epimedium, Morus alba and Semen Lepidii. Animal experiments show that the Chinese medicine composition has a significant relaxation effect on the isolated rat corpus cavernosum smooth muscle contracted by phenylephrine-induced contraction, has a strong effect of improving or treating male sexual dysfunction, and can be used to prepare a drug for male impotence and premature ejaculation.

Description

Technical Field

[0001] The present application relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for improving male impotence and premature ejaculation and its application. Background Art

[0002] Impotence, also known as erectile dysfunction (ED), is the most common male sexual dysfunction clinically. It usually refers to the inability of the penis to achieve or maintain an erection sufficient to complete a satisfactory sexual life, with a course of more than 3 months.

[0003] At present, Western medicines for treating ED include phosphodiesterase type 5 inhibitors (PDE5-Is), such as sildenafil, tadalafil, vardenafil, etc. In addition, there are many Chinese herbal medicines that can be used to treat or improve ED, such as wolfberry, deer antler, etc. However, there is no report in the prior art that the combination of Ligusticum chuanxiong and Ligusticum chuanxiong is used to prepare a product for improving male impotence and premature ejaculation. Summary of the invention

[0004] To solve the above problems, the present application provides a Chinese medicine composition for improving male impotence and premature ejaculation and its application.

[0005] In the first aspect, the present application provides a Chinese medicine composition for improving male impotence and premature ejaculation, wherein the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0006] 100-200 parts of Ligularia reticulata, 80-150 parts of Polygonum multiflorum, 20-40 parts of Rhodiola rosea, 1-10 parts of Ginseng, 1-10 parts of Epimedium, 1-10 parts of Morus alba and 1-5 parts of Semen serrata.

[0007] Furthermore, the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0008] 160-180 parts of Ligularia reticulata, 120-130 parts of Polygonum multiflorum, 25-30 parts of Rhodiola rosea, 5-10 parts of Ginseng, 4-8 parts of Epimedium, 5-10 parts of Morus alba and 1-5 parts of Semen serrata.

[0009] Furthermore, the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0010] 173 parts of Ligularia reticulata, 124 parts of Polygonum multiflorum, 25-30 parts of Rhodiola rosea, 5-10 parts of Ginseng, 4-8 parts of Epimedium, 5-10 parts of Morus alba and 1-5 parts of Semen Codonopsis pilosula.

[0011] Furthermore, the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0012] 173 parts of Ligularia reticulata, 124 parts of Polygonum multiflorum, 28 parts of Rhodiola rosea, 8 parts of Panax ginseng, 5 parts of Epimedium, 10 parts of Morus alba and 4 parts of Semen serrata.

[0013] Furthermore, the preparation method of the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following process:

[0014] Adding Ligularia reticulata and Achyranthes bidentata to water for a first reflux extraction and a first filtration to obtain a filter residue and a first extract;

[0015] Adding the filter residue, rhodiola rosea, ginseng, epimedium, mulberry and smilax glabra into ethanol for a second reflux extraction and a second filtration to obtain a second extract;

[0016] The first extract and the second extract are concentrated and dried to obtain the traditional Chinese medicine composition for improving male impotence and premature ejaculation.

[0017] Furthermore, the first reflux extraction is performed 1 to 3 times, and each reflux extraction lasts 2 to 3 hours.

[0018] Furthermore, the added weight of the water is 6 to 10 times the total weight of the Ligularia reticulata and the Achyranthes bidentata.

[0019] Furthermore, the volume fraction of the ethanol is 20-30%.

[0020] Furthermore, the second reflux extraction is performed 1 to 3 times, each reflux extraction lasts 1 to 2 hours, and the temperature of the second reflux extraction is 85 to 90°C.

[0021] Furthermore, the added weight of the ethanol is 8 to 12 times the total weight of the Chinese medicinal raw materials.

[0022] In a second aspect, the present application provides the use of the Chinese medicine composition described in any one of the first aspects in the preparation of a product for improving or treating male sexual dysfunction.

[0023] The above technical solution provided by the embodiment of the present application has at least the following advantages compared with the prior art:

[0024] The embodiment of the present application provides a traditional Chinese medicine composition for improving male impotence and premature ejaculation. The traditional Chinese medicine composition uses Ligularia reticulata and Achyranthes bidentata as main effective raw materials and is supplemented with a small amount of Rhodiola rosea, ginseng, epimedium, mulberry and rabbit silk seed. Animal experiments show that the traditional Chinese medicine composition has a significant relaxation effect on the isolated rat corpus cavernosum smooth muscle contracted by phenylephrine, has a strong effect of improving or treating male sexual dysfunction, and can be used to prepare a drug for male impotence and premature ejaculation. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution of the present application will be clearly and completely described below in combination with the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present application.

[0026] Unless otherwise specified, various raw materials, reagents, instruments and equipment used in this application can be purchased from the market or prepared by existing methods.

[0027] In the first aspect, the present application provides a Chinese medicine composition for improving male impotence and premature ejaculation, wherein the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0028] 100-200 parts of Ligularia reticulata, 80-150 parts of Polygonum multiflorum, 20-40 parts of Rhodiola rosea, 1-10 parts of Ginseng, 1-10 parts of Epimedium, 1-10 parts of Morus alba and 1-5 parts of Semen serrata.

[0029] Ligularia reticulata is the root of Ligularia reticulata, a plant of the genus Ligularia in the Asteraceae family. It has the effects of promoting lung function and regulating qi, relieving cough and removing phlegm. It is mainly used to treat colds and coughs.

[0030] Carduus crispus L. and C. acanthoides L. of the Asteraceae family are used as medicine in their entirety or in their roots. They have the effects of dispersing blood stasis and stopping bleeding, clearing away heat and promoting diuresis, and are used to treat dizziness, hematemesis, epistaxis, hematuria, functional uterine bleeding, leucorrhea, etc.

[0031] Rhodiola rosea is the dried root and rhizome of the Crassulaceae plant Rhodiola rosea. It has the effects of invigorating qi and promoting blood circulation, dredging meridians and relieving asthma.

[0032] Ginseng is the dried root and rhizome of the Araliaceae plant Panax ginseng. It has the effects of replenishing vital energy, restoring pulse and strengthening deficiency, nourishing spleen and lungs, promoting body fluid and nourishing blood, and calming the mind and improving intelligence.

[0033] Epimedium is the dried leaves of the plants Epimedium, Epimedium sagittatum, Epimedium pubescens or Epimedium koreanum of the Berberidaceae family. It has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism.

[0034] Mulberry is the dried fruit cluster of the mulberry plant of the Moraceae family. It has the effects of nourishing yin and blood, promoting body fluid and moistening dryness.

[0035] Cuscuta australis is the dried mature seeds of the Convolvulaceae plant Cuscuta australis or Cuscuta australis. It has the effects of nourishing the liver and kidneys, consolidating semen and reducing urination, stabilizing the fetus, improving eyesight, and stopping diarrhea.

[0036] The embodiment of the present application provides a traditional Chinese medicine composition for improving male impotence and premature ejaculation. The traditional Chinese medicine composition uses Ligularia reticulata and Achyranthes bidentata as main effective raw materials and is supplemented with a small amount of Rhodiola rosea, ginseng, epimedium, mulberry and rabbit silk seed. Animal experiments show that the traditional Chinese medicine composition has a significant relaxation effect on the isolated rat corpus cavernosum smooth muscle contracted by phenylephrine, has a strong effect of improving or treating male sexual dysfunction, and can be used to prepare a drug for male impotence and premature ejaculation.

[0037] Preferably, the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0038] 160-180 parts of Ligularia reticulata, 120-130 parts of Polygonum multiflorum, 25-30 parts of Rhodiola rosea, 5-10 parts of Ginseng, 4-8 parts of Epimedium, 5-10 parts of Morus alba and 1-5 parts of Semen serrata.

[0039] More preferably, the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0040] 173 parts of Ligularia reticulata, 124 parts of Polygonum multiflorum, 25-30 parts of Rhodiola rosea, 5-10 parts of Ginseng, 4-8 parts of Epimedium, 5-10 parts of Morus alba and 1-5 parts of Semen Codonopsis pilosula.

[0041] Most preferably, the Chinese medicine composition for improving male impotence and premature ejaculation comprises the following raw materials in parts by weight:

[0042] 173 parts of Ligularia reticulata, 124 parts of Polygonum multiflorum, 28 parts of Rhodiola rosea, 8 parts of Panax ginseng, 5 parts of Epimedium, 10 parts of Morus alba and 4 parts of Semen serrata.

[0043] It should be noted that, unless otherwise specified or specified, the components and raw materials involved in the traditional Chinese medicine composition for improving male impotence and premature ejaculation provided in the examples of the present application can be directly commercially available products.

[0044] As an implementation method of the present application, the preparation method of the Chinese medicine composition for improving male impotence and premature ejaculation includes the following process:

[0045] Adding Ligularia reticulata and Achyranthes bidentata to water for a first reflux extraction and a first filtration to obtain a filter residue and a first extract;

[0046] Adding the filter residue, rhodiola rosea, ginseng, epimedium, mulberry and smilax glabra into ethanol for a second reflux extraction and a second filtration to obtain a second extract;

[0047] The first extract and the second extract are concentrated and dried to obtain the traditional Chinese medicine composition for improving male impotence and premature ejaculation.

[0048] The preparation method of the Chinese medicine composition for improving male impotence and premature ejaculation provided in the present application combines water extraction and alcohol extraction, is simple to operate, does not require additional specific equipment, and is convenient for industrial production. The steps and parameters involved in the preparation method, unless otherwise specified or specifically described, can be carried out according to existing processes.

[0049] In some specific embodiments, the first reflux extraction is performed 1 to 3 times, and each reflux extraction lasts 2 to 3 hours.

[0050] In some specific embodiments, the added weight of the water is 6 to 10 times the total weight of the Ligularia reticulata and the Achyranthes bidentata.

[0051] In some specific embodiments, the volume fraction of the ethanol is 20-30%, and the added weight of the ethanol is 8-12 times the total weight of the traditional Chinese medicine raw material.

[0052] In some specific embodiments, the second reflux extraction is performed 1 to 3 times, each reflux extraction lasts 1 to 2 hours, and the temperature of the second reflux extraction is 85 to 90°C.

[0053] In a second aspect, based on a general inventive concept, the present application provides the use of the Chinese medicine composition described in any one of the first aspects in the preparation of a product for improving or treating male sexual dysfunction.

[0054] The Chinese medicine composition provided in the examples of the present application has been shown in animal experiments to have a significant relaxing effect on the isolated rat corpus cavernosum smooth muscle that was contracted induced by phenylephrine, has a strong effect in improving or treating male sexual dysfunction, and can be used to prepare drugs for male impotence and premature ejaculation.

[0055] The present application will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are intended only to illustrate the present application and are not intended to limit the scope of the present application. The experimental methods for which specific conditions are not specified in the following examples are usually measured according to national standards. If there is no corresponding national standard, then the conditions recommended by the manufacturer are followed.

[0056] Example 1

[0057] This example provides a traditional Chinese medicine composition for improving male impotence and premature ejaculation. Calculated by weight (each weight portion is 10g), the traditional Chinese medicine composition for improving male impotence and premature ejaculation includes the following raw materials: 100 parts of Ligularia reticulata, 80 parts of Polygonum multiflorum, 40 parts of Rhodiola rosea, 10 parts of ginseng, 10 parts of Epimedium, 10 parts of Morus alba and 5 parts of Semen Codonopsis pilosulae.

[0058] The preparation method of the above-mentioned Chinese medicine composition for improving male impotence and premature ejaculation comprises the following steps:

[0059] Step (1): crushing Ligularia reticulata and Achyranthes bidentata and adding them into water of 6 times the weight (the total weight of Ligularia reticulata and Achyranthes bidentata), performing a first reflux extraction at 110° C. for 2 hours, extracting once and filtering to obtain a filter residue and a first extract;

[0060] Step (2): adding the filter residue, rhodiola rosea, ginseng, epimedium, mulberry and radix strychnifoliae to ethanol for a second reflux extraction and a second filtration, adding the obtained second extract to 10 times the weight of ethanol with a volume fraction of 25%, performing reflux extraction at 86° C. for 2 hours, extracting twice, and obtaining a second extract;

[0061] Step (3): The first extract and the second extract are concentrated under reduced pressure and dried to a constant weight to obtain the Chinese medicine composition for improving male impotence and premature ejaculation.

[0062] Example 2

[0063] This example provides a Chinese medicine composition for improving male impotence and premature ejaculation, which differs from Example 1 only in that, by weight (each weight portion is 10 g), there are 200 parts of Ligularia reticulata, 150 parts of Achyranthes bidentata, 20 parts of Rhodiola rosea, 1 part of Ginseng, 1 part of Epimedium, 1 part of Morus alba and 1 part of Semen Codonopsis pilosulae; the remaining steps and parameters are the same.

[0064] Example 3

[0065] This example provides a traditional Chinese medicine composition for improving male impotence and premature ejaculation, which differs from Example 1 only in that, in terms of weight parts (each weight part is 10 g), the traditional Chinese medicine composition for improving male impotence and premature ejaculation includes the following raw materials: 160 parts of Ligularia reticulata, 120 parts of Polygonum multiflorum, 25 parts of Rhodiola rosea, 10 parts of Ginseng, 8 parts of Epimedium, 10 parts of Morus alba and 3 parts of Semen Codonopsis pilosulae; the remaining steps and parameters are the same.

[0066] Example 4

[0067] This example provides a traditional Chinese medicine composition for improving male impotence and premature ejaculation, which is different from Example 1 only in that: measured by weight (each weight portion is 10 g), the traditional Chinese medicine composition for improving male impotence and premature ejaculation includes the following raw materials: 180 parts of Ligularia reticulata, 130 parts of Polygonum multiflorum, 30 parts of Rhodiola rosea, 5 parts of Ginseng, 4 parts of Epimedium, 5 parts of Morus alba and 4 parts of Semen Oryzias; the remaining steps and parameters are the same.

[0068] Example 5

[0069] This example provides a traditional Chinese medicine composition for improving male impotence and premature ejaculation, which is different from Example 1 only in that: in terms of weight parts (each weight part is 10 g), the traditional Chinese medicine composition for improving male impotence and premature ejaculation includes the following raw materials: 173 parts of Ligularia reticulata, 124 parts of Achyranthes bidentata, 28 parts of Rhodiola rosea, 8 parts of Ginseng, 5 parts of Epimedium, 10 parts of Morus alba and 4 parts of Semen Oryzias; the remaining steps and parameters are the same.

[0070] Comparative Example 1

[0071] This example provides a Chinese medicine composition, which is different from Example 1 only in that the dosage of Ligularia reticulata is adjusted to 0 parts; the remaining steps and parameters are the same.

[0072] Comparative Example 2

[0073] This example provides a Chinese medicine composition, which is different from Example 1 only in that the amount of Achyranthes bidentata is adjusted to 0 parts; the other steps and parameters are the same.

[0074] Comparative Example 3

[0075] This example provides a Chinese medicine composition for improving male impotence and premature ejaculation, which is different from Example 1 only in that Rhodiola rosea is replaced with Carthamus tinctorius; the remaining steps and parameters are the same.

[0076] Comparative Example 4

[0077] This example provides a Chinese medicine composition, which is different from Example 1 only in that the amount of Ligularia reticulata is adjusted to 80 parts and the amount of Achyranthes bidentata is adjusted to 100 parts; the remaining steps and parameters are the same.

[0078] Test Case

[0079] In this example, the effects of the Chinese medicinal compositions for improving male impotence and premature ejaculation provided in Examples 1 to 5 and Comparative Examples 1 to 4 were tested.

[0080] Test method: 100 male SD rats weighing 255-300g were randomly divided into 10 groups, specifically a blank control group and experimental groups 1-9 (experimental groups 1-9 were given the Chinese medicine composition provided in Examples 1-5 and Comparative Examples 1-4, respectively). Experimental groups 1-9 were given intragastric administration at a dosage of 20 mg / kg / d, and the blank control group was given an equal volume of distilled water for 7 consecutive days. A rat penis erection reflex experiment was conducted 30 minutes after the last administration. The rats were placed in a glass experimental device, the environment was kept quiet and the light was dim, and the rats were filmed with a camera for 50 minutes, and the number of erections (the total number of erections of the rats within 50 minutes) and the erection time (the average time of each erection of the rats) were recorded. The test results are shown in Table 1.

[0081] Table 1

[0082]

[0083]

[0084] As can be seen from Table 1, compared with the blank control group and the comparative example group, the Chinese medicine composition provided in the embodiment of the present application has a significant relaxation effect on the isolated rat corpus cavernosum smooth muscle induced by phenylephrine, and has a strong effect of improving or treating male sexual dysfunction.

[0085] In summary, the embodiments of the present application provide a traditional Chinese medicine composition for improving male impotence and premature ejaculation. The traditional Chinese medicine composition uses Ligularia reticulata and Achyranthes bidentata as main effective raw materials and is supplemented with a small amount of Rhodiola rosea, ginseng, Epimedium, Morus alba and Semen Codonopsis pilosulae. Animal experiments have shown that the traditional Chinese medicine composition has a significant relaxation effect on the isolated rat corpus cavernosum smooth muscle contracted by phenylephrine-induced contraction, has a strong effect of improving or treating male sexual dysfunction, and can be used to prepare a drug for male impotence and premature ejaculation.

[0086] The above description is only a specific implementation of the present application, so that those skilled in the art can understand or implement the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest range consistent with the principles and novel features applied for herein.

Claims

1. A Chinese medicine composition for improving male impotence and premature ejaculation, characterized in that: The Chinese medicine composition for improving male impotence and premature ejaculation is composed of the following raw materials in parts by weight: 100-200 parts of Ligularia reticulata, 80-150 parts of Radix Achyranthis Bidentatae, 20-40 parts of Rhodiola rosea, 1-10 parts of Ginseng, 1-10 parts of Epimedium, 1-10 parts of Morus alba and 1-5 parts of Semen Codonopsis pilosulae.

2. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 1, characterized in that: The Chinese medicine composition for improving male impotence and premature ejaculation is composed of the following raw materials in parts by weight: 160-180 parts of Ligularia reticulata, 120-130 parts of Polygonum multiflorum, 25-30 parts of Rhodiola rosea, 5-10 parts of Ginseng, 4-8 parts of Epimedium, 5-10 parts of Morus alba and 1-5 parts of Semen serrata.

3. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 1, characterized in that: The Chinese medicine composition for improving male impotence and premature ejaculation is composed of the following raw materials in parts by weight: 173 parts of Ligularia reticulata, 124 parts of Polygonum multiflorum, 25-30 parts of Rhodiola rosea, 5-10 parts of Ginseng, 4-8 parts of Epimedium, 5-10 parts of Morus alba and 1-5 parts of Semen serrata.

4. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 1, characterized in that: The Chinese medicine composition for improving male impotence and premature ejaculation is composed of the following raw materials in parts by weight: 173 parts of Ligularia reticulata, 124 parts of Polygonum multiflorum, 28 parts of Rhodiola rosea, 8 parts of Panax ginseng, 5 parts of Epimedium, 10 parts of Morus alba and 4 parts of Semen serrata.

5. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 1, characterized in that: Preparation method of the traditional Chinese medicine composition for improving male impotence and premature ejaculation The process includes: Adding Ligularia reticulata and Achyranthes bidentata to water for a first reflux extraction and a first filtration to obtain a filter residue and a first extract; adding the filter residue, rhodiola rosea, ginseng, epimedium, mulberry and smilax glabra into ethanol for a second reflux extraction and a second filtration to obtain a second extract; The first extract and the second extract are concentrated and dried to obtain the traditional Chinese medicine composition for improving male impotence and premature ejaculation.

6. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 5, characterized in that: The number of the first reflux extraction is 1 to 3 times, and the time of each reflux extraction is 2 to 3 hours.

7. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 5, characterized in that: The added weight of the water is 6 to 10 times the total weight of the Ligularia reticulata and the Achyranthes bidentata.

8. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 5, characterized in that: The volume fraction of the ethanol is 20-30%, and the added weight of the ethanol is 8-12 times the total weight of the Chinese medicine raw material.

9. The Chinese medicine composition for improving male impotence and premature ejaculation according to claim 8, characterized in that: The number of the second reflux extraction is 1 to 3 times, the time of each reflux extraction is 1 to 2 hours, and the temperature of the second reflux extraction is 85 to 90°C.

10. Use of the Chinese medicine composition according to any one of claims 1 to 9 in the preparation of a drug for improving or treating male sexual dysfunction.

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