A spray composite disinfectant and its preparation method and application

Abstract

The present application relates to the technical field of disinfection in the breeding industry, and specifically discloses a spray composite disinfectant as well as a preparation method and application thereof.The spray composite disinfectant provided by the present application comprises the following components in mass percentage: 0.8-1% of quaternary ammonium salt surfactant, 1-1.5% of alkyl polyglycoside, 5-8% of cosolvent, and the balance of water; wherein the quaternary ammonium salt surfactant is a mixture of modified bisdecyl dimethyl ammonium chloride and hexadecyl dimethyl benzyl ammonium chloride; the alkyl polyglycoside is C12-C14 alkyl polyglycoside; and the modified bisdecyl dimethyl ammonium chloride is gamma-glycidyl ether oxygen propyl trimethoxysilane modified bisdecyl dimethyl ammonium chloride.The spray composite disinfectant provided by the present application is free of chlorine and phenols, is safe and non-toxic, is green and healthy, has a simple preparation and use method, has good compatibility, has good storage performance, and is easy to realize large-scale production.

Description

Technical Field

[0001] This invention relates to the field of disinfection technology in aquaculture, and in particular to a spray compound disinfectant, its preparation method, and its application. Background Technology

[0002] In pursuit of economies of scale, livestock and poultry farming has led to continuously increasing stocking densities. However, this increases can negatively impact animal populations, causing stress and resulting in weakened immunity and increased susceptibility to disease. Combined with factors such as inadequate technical management practices, this further exacerbates the problem, making animals more susceptible to disease and its rapid spread.

[0003] Disinfection is one of the most important aspects of aquaculture management. However, existing disinfectants generally have a certain degree of toxicity and irritation to the mucous membranes and respiratory tracts of organisms, and also possess corrosive, flammable, and even toxic properties, making them unsuitable for use in environments with organisms. Consequently, farms can only disinfect when the sheds are empty, and disinfection is not possible during the aquaculture period. Furthermore, long-term use can easily cause environmental damage. To reduce the irritation, toxicity, and cost of disinfectants, they can be diluted before use. However, existing disinfectants, especially after high-level dilution, exhibit a sharp decline in disinfection and sterilization effectiveness, failing to meet the requirements of the Ministry of Health's "Disinfection Technical Specifications." Therefore, providing an environmentally friendly, highly efficient, and long-lasting spray-on compound disinfectant is of great significance. Summary of the Invention

[0004] In view of this, in order to solve the problems of high toxicity and poor bactericidal effect of existing disinfectants, the present invention provides a spray compound disinfectant, its preparation method and application.

[0005] To solve the above-mentioned technical problems, the technical solution provided by the present invention is as follows:

[0006] This invention provides a spray-on composite disinfectant comprising the following components by mass percentage: 0.8%-1% quaternary ammonium salt surfactant, 1%-1.5% alkyl glycoside, 5%-8% cosolvent, and the balance being water;

[0007] The quaternary ammonium salt surfactant is a mixture of modified dicedyldimethylammonium chloride and hexadecyldimethylbenzylammonium chloride;

[0008] The alkyl glycoside is a C12-C14 alkyl glycoside;

[0009] The modified diecryldimethylammonium chloride is γ-glycidyl etheroxypropyltrimethoxysilane modified diecryldimethylammonium chloride.

[0010] Compared to existing technologies, the spray-on composite disinfectant provided by this invention solves the problem of the lack of long-lasting bactericidal effect of decyl dimethyl ammonium chloride by adding γ-glycidoxypropyltrimethoxysilane-modified dialcyl dimethyl ammonium chloride, greatly improving the disinfectant's long-lasting bactericidal effect. This invention also adds hexadecyl dimethyl benzyl ammonium chloride, which, through synergistic action with the modified dialcyl dimethyl ammonium chloride, enables the prepared disinfectant to achieve a highly efficient bactericidal effect. The specific alkyl glycosides and quaternary ammonium salt surfactants used in combination not only improve the dispersibility of the quaternary ammonium salt surfactants but also enhance the wetting properties of the disinfectant, giving the prepared spray-on composite disinfectant both a highly efficient and long-lasting bactericidal effect. The synergistic effect of the components of this invention greatly improves the performance of the spray-on composite disinfectant, enabling it to possess both highly efficient and long-lasting bactericidal characteristics.

[0011] Preferably, the alkyl glycoside is JC24PC from Guangzhou Jianchuang Biotechnology Co., Ltd.

[0012] Preferably, the preparation of the modified diecryldimethylammonium chloride includes the following steps:

[0013] Add diecryldimethylammonium chloride to a solvent, then add γ-glycidoxypropyltrimethoxysilane and a catalyst, react at 80℃-100℃, and distill under reduced pressure to obtain modified diecryldimethylammonium chloride.

[0014] By modifying dialcdimethylammonium chloride with γ-glycidoxypropyltrimethoxysilane, specific organosilicones are introduced into dialcdimethylammonium chloride, improving its adsorption performance on bacteria. Furthermore, the functional groups of dialcdimethylammonium chloride are modified to penetrate into the bacterial cell wall and kill bacteria, solving the problem of the short-lasting bactericidal effect of dialcdimethylammonium chloride when used alone, and greatly improving the durability of bactericidal action.

[0015] Preferably, the solvent is at least one of anhydrous ethanol or anhydrous methanol.

[0016] Preferably, the catalyst is potassium iodide.

[0017] Preferably, the molar ratio of the diecryldimethylammonium chloride and γ-glycidoxypropyltrimethoxysilane is 1:(4-6).

[0018] Preferably, the molar ratio of the diecryldimethylammonium chloride to the catalyst is 1:(0.2-0.3).

[0019] Preferably, the reaction time is 4-5 hours.

[0020] Preferably, the quaternary ammonium salt surfactant is a mixture of modified dicedyldimethylammonium chloride and hexadecyldimethylbenzylammonium chloride in a mass ratio of 1:(0.6-0.7).

[0021] Preferably, the co-solvent is at least one of anhydrous ethanol, isopropanol, or n-butanol.

[0022] The present invention also provides a method for preparing the above-mentioned spray compound disinfectant, comprising the following steps:

[0023] Weigh each component according to the mass ratio, add the weighed quaternary ammonium salt surfactant, alkyl glycoside, synergist and cosolvent to water, mix evenly to obtain a spray compound disinfectant.

[0024] This invention provides the application of the above-mentioned spray compound disinfectant in livestock and poultry farming.

[0025] The spray compound disinfectant provided by this invention is free of chlorine and phenols, is safe and non-toxic, green and healthy, and has a highly efficient and long-lasting bactericidal effect. It has a wide range of applications and causes less stress to livestock and poultry. Moreover, the preparation and use of the spray compound disinfectant are simple, it has good compatibility, good storage performance, and is easy to achieve large-scale production. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0027] To better illustrate the present invention, further examples are provided below.

[0028] Example 1

[0029] This embodiment provides a spray-on composite disinfectant, comprising the following components by mass percentage: 0.8% quaternary ammonium salt surfactant, 1.5% alkyl glycoside JC24PC, 5% n-butanol, and the balance being water;

[0030] The quaternary ammonium salt surfactant is a mixture of modified decyl dimethyl ammonium chloride and hexadecyl dimethyl benzyl ammonium chloride in a mass ratio of 1:0.7;

[0031] The preparation of the modified disedecyldimethylammonium chloride includes the following steps:

[0032] Add diecryldimethylammonium chloride to anhydrous ethanol, then add γ-glycidoxypropyltrimethoxysilane and potassium iodide, react at 80°C for 4 h, and distill under reduced pressure to obtain modified diecryldimethylammonium chloride.

[0033] The molar ratio of diecryldimethylammonium chloride to γ-glycidoxypropyltrimethoxysilane is 1:4, and the molar ratio of diecryldimethylammonium chloride to potassium iodide is 1:0.2.

[0034] Example 2

[0035] This embodiment provides a spray-on composite disinfectant, comprising the following components by mass percentage: 1% quaternary ammonium salt surfactant, 1% alkyl glycoside JC24PC, 8% isopropanol, and the balance being water;

[0036] The quaternary ammonium salt surfactant is a mixture of modified dicedyldimethylammonium chloride and hexadecyldimethylbenzylammonium chloride in a mass ratio of 1:0.6;

[0037] The preparation of the modified disedecyldimethylammonium chloride includes the following steps:

[0038] Add diecryldimethylammonium chloride to anhydrous methanol, then add γ-glycidoxypropyltrimethoxysilane and potassium iodide, react at 100°C for 5 h, and distill under reduced pressure to obtain modified diecryldimethylammonium chloride.

[0039] The molar ratio of diecryldimethylammonium chloride to γ-glycidoxypropyltrimethoxysilane is 1:6, and the molar ratio of diecryldimethylammonium chloride to potassium iodide is 1:0.3.

[0040] Example 3

[0041] This embodiment provides a spray-on composite disinfectant, comprising the following components by mass percentage: 0.9% quaternary ammonium salt surfactant, 1.3% alkyl glycoside JC24PC, 6% isopropanol, and the balance being water;

[0042] The quaternary ammonium salt surfactant is a mixture of modified dicedyldimethylammonium chloride and hexadecyldimethylbenzylammonium chloride in a mass ratio of 1:0.65;

[0043] The preparation of the modified disedecyldimethylammonium chloride includes the following steps:

[0044] Add diecryldimethylammonium chloride to anhydrous methanol, then add γ-glycidoxypropyltrimethoxysilane and potassium iodide, react at 90 °C for 4.5 h, and distill under reduced pressure to obtain modified diecryldimethylammonium chloride;

[0045] The molar ratio of diecryldimethylammonium chloride to γ-glycidoxypropyltrimethoxysilane is 1:5, and the molar ratio of diecryldimethylammonium chloride to potassium iodide is 1:0.25.

[0046] Comparative Example 1

[0047] Compared with Example 1, the difference between this comparative example and Example 1 is that the alkyl glycoside JC24PC is replaced with an equal amount of APG0810 from Jiangsu Wanqi Biotechnology Co., Ltd., and the other operating steps are the same as in Example 1.

[0048] Comparative Example 2

[0049] Compared with Example 1, the difference between this comparative example and Example 1 is that the alkyl glycoside JC24PC is replaced with an equal amount of alcohol ether glycoside AEG500 from Jiangsu Wanqi Biotechnology Co., Ltd., and the other operating steps are the same as in Example 1.

[0050] Comparative Example 3

[0051] Compared with Example 1, the difference between this comparative example and Example 1 is that γ-glycidoxypropyltrimethoxysilane is replaced with an equal amount of vinyltrimethoxysilane, and bisdecyldimethylammonium chloride is modified with vinyltrimethoxysilane. Other operating steps are the same as in Example 1.

[0052] Application examples

[0053] 1. Sterilization effect

[0054] Location: Livestock and poultry breeding base

[0055] Spray disinfection was performed using the spray composite disinfectants prepared in Examples 1-3 and Comparative Examples 1-3 of this invention, respectively, at a dosage of 100 mL / m³. 2 Samples were taken 30 minutes before disinfection, 60 minutes after disinfection, and 10 hours after disinfection for airborne microbial culture to observe the disinfection effect. The airborne microbial count was determined using the plate colony-forming method. 90mm diameter bacterial culture dishes were used, with one point each at the center of the room and at each of the four corners, 1m from the wall, at a height of 90cm from the ground. After exposing the bacterial culture dishes to the air for 5 minutes, microbial culture was performed, and the dishes were incubated at 37℃ for 48 hours. Colony counts were then recorded. The bacterial kill rate was calculated according to the Ministry of Health's "Hospital Disinfection Technical Specifications," as detailed in Table 1.

[0056] Table 1

[0057]

[0058]

[0059] The test data in Table 1 show that the disinfectant prepared by this invention has excellent bactericidal effect, with a bactericidal rate reaching over 99%. The bactericidal effect of the examples is significantly better than that of the comparative examples, indicating that the present invention, through reasonable formulation, obtains a scientifically sound disinfectant with the best bactericidal effect.

[0060] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions or improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A spray-on compound disinfectant, characterized in that, It comprises the following components by mass percentage: 0.8%-1% quaternary ammonium salt surfactant, 1%-1.5% alkyl glycoside, 5%-8% cosolvent, and the balance being water; The quaternary ammonium salt surfactant is a mixture of modified dicedyldimethylammonium chloride and hexadecyldimethylbenzylammonium chloride; The alkyl glycoside is a C12-C14 alkyl glycoside; The modified diecryldimethylammonium chloride is γ-glycidyl etheroxypropyltrimethoxysilane modified diecryldimethylammonium chloride; The preparation of the modified diecryldimethylammonium chloride includes the following steps: adding diecryldimethylammonium chloride to a solvent, then adding γ-glycidoxypropyltrimethoxysilane and a catalyst, reacting at 80℃-100℃, and distilling under reduced pressure to obtain modified diecryldimethylammonium chloride.

2. The spray-on composite disinfectant as described in claim 1, characterized in that, The solvent is at least one of anhydrous ethanol or anhydrous methanol.

3. The spray-on compound disinfectant as described in claim 1, characterized in that, The catalyst is potassium iodide.

4. The spray-on compound disinfectant as described in claim 1, characterized in that, The molar ratio of the dic(2-decyl)dimethylammonium chloride to γ-glycidoxypropyltrimethoxysilane is 1:(4-6).

5. The spray-on compound disinfectant as described in claim 1, characterized in that, The molar ratio of the diecryldimethylammonium chloride to the catalyst is 1:(0.2-0.3); and / or the reaction time is 4-5 h.

6. The spray-on compound disinfectant as described in claim 1, characterized in that, The quaternary ammonium salt surfactant is a mixture of modified dicedyldimethylammonium chloride and hexadecyldimethylbenzylammonium chloride in a mass ratio of 1:(0.6-0.7).

7. The spray-on compound disinfectant as described in claim 1, characterized in that, The co-solvent is at least one of anhydrous ethanol, isopropanol, or n-butanol.

8. A method for preparing a spray-on composite disinfectant according to any one of claims 1-7, characterized in that, Includes the following steps: Weigh each component according to the mass ratio, add the weighed quaternary ammonium salt surfactant, alkyl glycoside, synergist and cosolvent to water, mix evenly to obtain a spray compound disinfectant.

9. The application of the spray compound disinfectant according to any one of claims 1-7 in livestock and poultry farming.

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