Traditional Chinese medicine composition, oral liquid for treating rhinitis, preparation method and application thereof

Abstract

The present invention relates to a traditional Chinese medicine composition, an oral liquid for treating rhinitis, and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: stir-fried Xanthii Fructus 10-45 parts, Magnoliae Flos 10-45 parts, Angelicae Dahuricae Radix 10-30 parts, Taraxaci Herba 10-35 parts, Gynostemmae Pentaphylli Herba 5-20 parts, Rhodiolae Roseae Radix 10-35 parts, Astragali Radix 10-30 parts, and stir-fried Atractylodis Macrocephalae Rhizoma 10-30 parts. The oral liquid prepared from the traditional Chinese medicine composition of the present invention can effectively treat mild and moderate rhinitis, has the effects of anti-allergy, immunosuppression, anti-inflammation and analgesia, has a relatively high total effective rate, and is not likely to relapse after drug withdrawal. At the same time, the present invention pays more attention to clearing and dispersing the lung qi, replenishing qi and strengthening the spleen, having supplementation in purgation, can regulate the body immunity, correct immune imbalance, and achieve the effect of treating both the symptoms and the root causes. The present invention has great medical value and broad application prospects in the field of treating rhinitis.

Description

Technical Field

[0001] The present invention relates to a traditional Chinese medicine composition, oral liquid for treating rhinitis, and its preparation method and application, belonging to the technical field of traditional Chinese medicine. Background Art

[0002] Rhinitis is a common and frequently-occurring disease in otorhinolaryngology. It is a group of inflammatory lesions occurring in the nasal mucosa caused by various factors, and its main clinical features are runny nose, nasal itching, nasal congestion, sneezing and headache, etc. The prevalence of rhinitis is relatively high (10% - 20%) worldwide and is increasing year by year. At the same time, because this disease is difficult to cure and there is no specific treatment method, it not only reduces the work efficiency and quality of life of patients, but also consumes a large amount of medical and health resources, increasing the social and economic burden.

[0003] At present, the first-line drugs for clinical treatment of acute and chronic rhinitis are mainly local nasal medications (nasal glucocorticoids, nasal antihistamines, nasal decongestants, nasal saline irrigation, etc.); systemic medications are often used as adjuvant treatment means (mainly oral), and oral antiviral drugs, antibacterial drugs, antihistamines, leukotriene antagonists, glucocorticoids, decongestants and mucolytics can be appropriately used according to the situation. Although these treatment means can quickly relieve symptoms, they cannot completely cure rhinitis. In addition, this disease is prone to recurrence, and long-term use of the above treatment methods will increase the incidence of adverse reactions.

[0004] Compared with modern medical treatment methods which have disadvantages such as easy recurrence and relatively large side effects, traditional Chinese medicine and its compound drugs have unique advantages in the clinical treatment of rhinitis, and can avoid the danger of anaphylactic shock that may be caused by desensitization treatment and adverse reactions such as drowsiness caused by antihistamine drugs. At the same time, traditional Chinese medicine adjusts the body's immunity as a whole from a dialectical thinking, thereby improving the curative effect of the drug, with relatively small toxic and side effects and can be applied for a long time. Therefore, it has important practical significance to devote to the research and development of modern traditional Chinese medicine drugs for the treatment of nasal diseases. Summary of the Invention

[0005] In order to solve the disadvantages of modern medicine in the clinical treatment of rhinitis, such as easy recurrence and relatively large side effects, the present invention provides a traditional Chinese medicine composition, oral liquid for treating rhinitis, and its preparation method and application. The traditional Chinese medicine composition described in the present invention and the oral liquid prepared by using the preparation process of the present invention can effectively treat mild and moderate rhinitis, have the effects of anti-allergy, immunosuppression, anti-inflammation and analgesia, with a relatively high total effective rate and not easy to relapse after stopping the drug. At the same time, the process method of the present invention has low cost, is safe, simple and convenient for quality control. The present invention has great medical value in the field of treating rhinitis.

[0006] The Chinese medicine composition for treating rhinitis of the present invention is obtained by adding and subtracting the famous prescription "Xinyi Powder" in "Pianyu Xinshu" written by Wan Quan, a doctor in the Ming Dynasty. In the field of traditional Chinese medicine, rhinitis is caused by lung and spleen deficiency, insufficient vital energy, loose pores, weak defensive surface, invasion of wind evil, cold evil or foreign air, etc. The lung governs qi and opens the orifices in the nose, the spleen and stomach are the source of qi and blood biochemical transformation, and the defensive qi originates from the water and grain essence transported by the spleen and stomach. Therefore, lung and spleen deficiency is closely related to the occurrence and development of rhinitis. The present invention not only treats rhinitis symptoms, relieves inflammation and clears the orifices in the clinic, but also focuses on clearing and dispersing lung qi, invigorating qi and strengthening spleen, and tonifying in purging, so as to treat both the symptoms and the root causes, not easily damage the vital energy of the human body, but also regulate the body's immunity and correct immune imbalance.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] The invention provides a traditional Chinese medicine composition for treating rhinitis. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-45 parts of stir-fried Xanthium sibiricum fruit, 10-45 parts of magnolia, 10-30 parts of angelica dahurica, 10-35 parts of dandelion, 5-20 parts of Gynostemma pentaphyllum, 10-35 parts of Rhodiola rosea, 10-30 parts of Astragalus and 10-30 parts of stir-fried Atractylodes macrocephala.

[0009] In the present invention, the Chinese medicine composition for treating rhinitis preferably further comprises 2-10 portions of raw licorice.

[0010] In the present invention, the stir-fried Xanthium sibiricum is preferably 10 parts, 20 parts, 30 parts, 40 parts and 45 parts.

[0011] In the present invention, the magnolia is preferably in an amount of 10 parts, 20 parts, 30 parts, 40 parts and 45 parts.

[0012] In the present invention, the Angelica dahurica is preferably in an amount of 10 parts, 12 parts, 20 parts, 24 parts and 30 parts.

[0013] In the present invention, the dandelion is preferably 10 parts, 15 parts, 30 parts and 35 parts.

[0014] In the present invention, the amount of Gynostemma pentaphyllum is preferably 10 parts and 20 parts.

[0015] In the present invention, the Rhodiola rosea is preferably 15 parts, 20 parts, 30 parts and 35 parts.

[0016] In the present invention, the Astragalus membranaceus is preferably 10 parts, 20 parts and 30 parts.

[0017] In the present invention, the stir-fried Atractylodes macrocephala is preferably 12 parts, 20 parts, 24 parts and 30 parts.

[0018] In the present invention, the raw liquorice is preferably 2 parts, 5 parts, 8 parts and 10 parts.

[0019] In some preferred embodiments of the present invention, the traditional Chinese medicine composition for treating rhinitis is composed of the following components in parts by weight: stir-fried Xanthii Fructus 10 - 45 parts, Magnoliae Flos 10 - 45 parts, Angelicae Dahuricae Radix 10 - 30 parts, Taraxaci Herba 10 - 35 parts, Gynostemmae Pentaphylli Herba 5 - 20 parts, Rhodiolae Crenulatae Radix et Rhizoma 10 - 35 parts, Astragali Radix 10 - 30 parts, stir-fried Atractylodis Macrocephalae Rhizoma 10 - 30 parts, and Glycyrrhizae Radix 2 - 10 parts.

[0020] In some preferred embodiments of the present invention, the traditional Chinese medicine composition for treating rhinitis includes the following components in parts by weight: stir-fried Xanthii Fructus 10 - 45 parts, Magnoliae Flos 20 - 45 parts, Angelicae Dahuricae Radix 12 - 30 parts, Taraxaci Herba 15 - 35 parts, Gynostemmae Pentaphylli Herba 10 - 20 parts, Rhodiolae Crenulatae Radix et Rhizoma 15 - 35 parts, Astragali Radix 10 - 30 parts, stir-fried Atractylodis Macrocephalae Rhizoma 12 - 30 parts, and Glycyrrhizae Radix 2 - 10 parts.

[0021] In some preferred embodiments of the present invention, the traditional Chinese medicine composition for treating rhinitis includes the following components in parts by weight: stir-fried Xanthii Fructus 20 - 40 parts, Magnoliae Flos 20 - 40 parts, Angelicae Dahuricae Radix 20 - 30 parts, Taraxaci Herba 15 - 30 parts, Gynostemmae Pentaphylli Herba 10 - 20 parts, Rhodiolae Crenulatae Radix et Rhizoma 20 - 30 parts, Astragali Radix 10 - 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 12 - 24 parts, and Glycyrrhizae Radix 5 - 10 parts.

[0022] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis includes the following components in parts by weight: stir-fried Xanthii Fructus 45 parts, Magnoliae Flos 45 parts, Angelicae Dahuricae Radix 30 parts, Taraxaci Herba 35 parts, Gynostemmae Pentaphylli Herba 20 parts, Rhodiolae Crenulatae Radix et Rhizoma 35 parts, Astragali Radix 30 parts, stir-fried Atractylodis Macrocephalae Rhizoma 30 parts, and Glycyrrhizae Radix 10 parts.

[0023] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis includes the following components in parts by weight: stir-fried Xanthii Fructus 45 parts, Magnoliae Flos 45 parts, Angelicae Dahuricae Radix 30 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Crenulatae Radix et Rhizoma 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix 8 parts.

[0024] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis includes the following components in parts by weight: stir-fried Xanthii Fructus 40 parts, Magnoliae Flos 40 parts, Angelicae Dahuricae Radix 24 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Crenulatae Radix et Rhizoma 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 24 parts, and Glycyrrhizae Radix 5 parts.

[0025] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis includes the following components in parts by weight: stir-fried Xanthii Fructus 40 parts, Magnoliae Flos 40 parts, Angelicae Dahuricae Radix 24 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Crenulatae Radix et Rhizoma 30 parts, Astragali Radix 10 parts, stir-fried Atractylodis Macrocephalae Rhizoma 12 parts, and Glycyrrhizae Radix 5 parts.

[0026] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 40 parts, Magnoliae Flos 40 parts, Angelicae Dahuricae Radix 24 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 15 parts, Astragali Radix 10 parts, stir-fried Atractylodis Macrocephalae Rhizoma 12 parts, and Glycyrrhizae Radix Preparata 5 parts.

[0027] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 30 parts, Magnoliae Flos 30 parts, Angelicae Dahuricae Radix 20 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 24 parts, and Glycyrrhizae Radix Preparata 10 parts.

[0028] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 30 parts, Magnoliae Flos 30 parts, Angelicae Dahuricae Radix 20 parts, Taraxaci Herba 15 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 20 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 24 parts, and Glycyrrhizae Radix Preparata 10 parts.

[0029] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 20 parts, Magnoliae Flos 20 parts, Angelicae Dahuricae Radix 12 parts, Taraxaci Herba 15 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 15 parts, Astragali Radix 10 parts, stir-fried Atractylodis Macrocephalae Rhizoma 12 parts, and Glycyrrhizae Radix 2 parts.

[0030] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 20 parts, Magnoliae Flos 20 parts, Angelicae Dahuricae Radix 12 parts, Taraxaci Herba 15 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix Preparata 5 parts.

[0031] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 10 parts, Magnoliae Flos 30 parts, Angelicae Dahuricae Radix 30 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix Preparata 5 parts.

[0032] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 10 parts, Magnoliae Flos 10 parts, Angelicae Dahuricae Radix 10 parts, Taraxaci Herba 10 parts, Gynostemmae Pentaphylli Herba 20 parts, Rhodiolae Roseae Radix 20 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 30 parts, and Glycyrrhizae Radix Preparata 5 parts.

[0033] In a specific embodiment of the present invention, the traditional Chinese medicine composition for treating rhinitis comprises the following components in parts by weight: stir-fried Xanthii Fructus 10 parts, Magnoliae Flos 10 parts, Angelicae Dahuricae Radix 20 parts, Taraxaci Herba 10 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 20 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix Preparata 5 parts.

[0034] In the present invention, the stir-fried Xanthium sibiricum has the effects of treating headache due to wind-cold, nasal sinusitis and itching; the Flos Magnoliae can cause vasoconstriction of the nasal mucosa, promote the absorption of mucosal secretions, and reduce inflammation; the Radix Angelicae Dahuricae dispels exterior cold and wind and opens the orifices. The combination of these three as the monarch drugs can enhance the effects of dispersing wind-cold and opening the nasal orifices.

[0035] In the present invention, the Taraxacum mongolicum can clear heat and detoxify, purge qi stagnation, disperse swelling and dissipate binds, and activate the body's immunity; the Gynostemma pentaphyllum has the curative effects of clearing heat and detoxifying, replenishing qi and strengthening the spleen, resolving phlegm and relieving cough, and increasing the cellular immunity, humoral immunity and non-specific immune functions of the body; the Rhodiola rosea can clear the lung and relieve cough, invigorate the spleen and replenish qi, promote blood circulation and remove stasis, and at the same time resist fatigue, antioxidize and improve mental activity. Both the Gynostemma pentaphyllum and the Rhodiola rosea belong to the lung and spleen meridians, with clearing and tonifying properties. The combination with the Taraxacum mongolicum as the ministerial drugs can not only treat the symptoms of deficiency of the lung and spleen with latent pathogenic heat, but also improve the problem of decreased learning ability or work efficiency caused by headache and dizziness in patients with rhinitis.

[0036] In the present invention, the Astragalus membranaceus and the stir-fried Atractylodes macrocephala are the adjuvant drugs, having the effects of replenishing qi and strengthening the spleen, invigorating the spleen and benefiting the lung. According to the theory of "strengthening the earth to generate metal" in the five-element theory, invigorating the spleen and replenishing qi can effectively improve the symptoms of deficiency of lung qi, and since the spleen and stomach are the sources of qi and blood generation, it can also effectively improve the symptoms of insecurity of the defensive exterior.

[0037] In the present invention, the raw Glycyrrhiza uralensis is the guiding drug, having the curative effect of clearing heat and detoxifying, and can harmonize the properties of various drugs.

[0038] The present invention also provides a preparation method of an oral liquid for treating rhinitis, which uses the above-mentioned traditional Chinese medicine composition for treating rhinitis as the raw material, and includes the following steps:

[0039] S1: Distill the Flos Magnoliae to obtain a Flos Magnoliae distillate;

[0040] S2: Add the other components except the Flos Magnoliae in the traditional Chinese medicine composition for treating rhinitis to the Flos Magnoliae medicinal residues obtained in step S1, decoct with water, and concentrate to obtain a primary concentrated liquid; add an ethanol aqueous solution to the primary concentrated liquid, and concentrate under reduced pressure to obtain a secondary concentrated liquid; add water to the secondary concentrated liquid, filter, and collect the filtrate;

[0041] S3: Mix the filtrate obtained in step S2 and the Flos Magnoliae distillate obtained in step S1 to obtain a mixed liquid, filter, and boil and sterilize.

[0042] In step S1, the distillation can be carried out by a conventional distillation method in the art. Preferably, the operation of the distillation includes soaking in water for 24 hours first, and then extracting at a slightly boiling state for 8 hours.

[0043] In step S2, the operation of the decoction can be conventional in the art. Preferably, the decoction is carried out twice, each time for 2 hours.

[0044] In step S2, the volume fraction of ethanol in the aqueous ethanol solution is preferably 50% to 80%, for example, 65%.

[0045] In step S2, the volume ratio of the primary concentrate to the aqueous ethanol solution is preferably 1:(5 - 20), for example, 1:10.

[0046] In step S2, preferably, after adding the aqueous ethanol solution to the primary concentrate, steps of standing and refrigerating are further included; among them, the refrigerating is preferably refrigerating at 2 - 10°C for 48 hours.

[0047] In step S2, preferably, after adding water to the secondary concentrate, a refrigerating step is further included; among them, the refrigerating is preferably refrigerating at 2 - 10°C for 48 hours.

[0048] In step S2, preferably, distilled water is added to the secondary concentrate.

[0049] In step S3, preferably, excipients and / or water are further added to the mixture.

[0050] Among them, the excipients can be excipients commonly used in oral liquids, such as sweeteners and / or preservatives. Further, the sweetener is, for example, granulated sugar; the preservative is, for example, sodium benzoate.

[0051] Among them, the water is preferably purified water.

[0052] In the present invention, operations such as concentration, filtration, mixing, and boiling sterilization can all be carried out by conventional operations in the art.

[0053] The present invention also provides an oral liquid for treating rhinitis, which is prepared by using the preparation method of the above-mentioned oral liquid for treating rhinitis.

[0054] In the present invention, the specification of the oral liquid can be 10 mL / branch.

[0055] The present invention also provides the application of the traditional Chinese medicine composition for treating rhinitis or the oral liquid for treating rhinitis in the preparation of a drug for treating rhinitis.

[0056] On the basis of conforming to common knowledge in the art, the above-mentioned preferred conditions can be combined arbitrarily to obtain various preferred examples of the present invention.

[0057] The reagents and raw materials used in the present invention are all commercially available.

[0058] The positive and progressive effects of the present invention are as follows:

[0059] (1) The traditional Chinese medicine composition and oral liquid for treating rhinitis according to the present invention have the advantages of being safe, non-toxic, mild in property, and having the effects of anti-allergy, immunosuppression, anti-inflammation, and analgesia. At the same time, compared with drugs such as antihistamines, anti-leukotrienes, glucocorticoids, decongestants, and mucolytics, the total effective rate is relatively high, and the recurrence frequency can be reduced after stopping the drug.

[0060] (2) The traditional Chinese medicine composition and oral liquid for treating rhinitis according to the present invention can not only effectively treat the surface symptoms of rhinitis, eliminate inflammation and open the orifices, but also focus on clearing and dispersing the lung qi, tonifying qi and strengthening the spleen, having supplement in purging, improving the symptoms of lung and spleen deficiency and insecurity of the defensive exterior, and achieving the effect of treating both the symptoms and the root causes.

[0061] (3) The traditional Chinese medicine composition and oral liquid for treating rhinitis according to the present invention can regulate the body's immunity, correct immune imbalance, and improve the problem of decreased learning ability or work efficiency caused by headache and dizziness in rhinitis patients.

[0062] (4) The preparation method of the traditional Chinese medicine composition and oral liquid for treating rhinitis according to the present invention has low cost, is safe and simple, and is convenient for quality control.

[0063] (5) The traditional Chinese medicine composition, oral liquid and their preparation methods for treating rhinitis according to the present invention have great medical value and broad application prospects in the field of treating rhinitis. Detailed implementation mode

[0064] The present invention will be further illustrated by the following examples, but the present invention is not limited to the scope of the described examples. The experimental methods without specific conditions noted in the following examples are carried out according to conventional methods and conditions, or selected according to the product instructions.

[0065] Example 1

[0066] A traditional Chinese medicine composition for treating rhinitis, which includes, by weight parts: stir-fried Xanthium sibiricum 45 parts, Magnolia liliflora Desr. 45 parts, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. 30 parts, Taraxacum mongolicum Hand.-Mazz. 35 parts, Gynostemma pentaphyllum (Thunb.) Makino 20 parts, Rhodiola rosea L. 35 parts, Astragalus membranaceus (Fisch.) Bunge 30 parts, stir-fried Atractylodes macrocephala Koidz. 30 parts, and raw Glycyrrhiza uralensis Fisch. 10 parts.

[0067] Using this traditional Chinese medicine composition as the raw material, an oral liquid for treating rhinitis is prepared, which specifically includes the following steps:

[0068] S1: Accurately weigh the ground Magnolia liliflora Desr. into a 1000 mL distillation flask, soak it in water for 24 hours first, and then carry out extraction. Start timing when it reaches a gentle boil, and extract for 8 hours under the gentle boiling state to obtain the Magnolia liliflora Desr. distillate;

[0069] S2: Add other components to the magnolia officinalis residue obtained in step S1, decoct with water twice, each time for 2 hours, and concentrate to obtain a primary concentrated solution; add 65% ethanol aqueous solution to the primary concentrated solution, let it stand, refrigerate at 2 - 10 °C for 48 hours, concentrate under reduced pressure to obtain a secondary concentrated solution, add distilled water to the secondary concentrated solution, refrigerate at 2 - 10 °C for 48 hours, filter, and collect the filtrate;

[0070] S3: Add the filtrate obtained in step S2 to the magnolia officinalis distillate obtained in step S1 to obtain a mixed solution, add granulated sugar, sodium benzoate and purified water, filter, boil and sterilize to obtain the oral liquid for treating rhinitis.

[0071] Example 2

[0072] A traditional Chinese medicine composition for treating rhinitis, which includes by weight: 45 parts of stir-fried xanthium sibiricum, 45 parts of magnolia officinalis, 30 parts of angelica dahurica, 30 parts of dandelion, 10 parts of gynostemma pentaphyllum, 30 parts of rhodiola rosea, 20 parts of astragalus membranaceus, 20 parts of stir-fried atractylodes macrocephala and 8 parts of raw licorice.

[0073] Using this traditional Chinese medicine composition as the raw material, prepare the oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0074] Example 3

[0075] A traditional Chinese medicine composition for treating rhinitis, which includes by weight: 40 parts of stir-fried xanthium sibiricum, 40 parts of magnolia officinalis, 24 parts of angelica dahurica, 30 parts of dandelion, 10 parts of gynostemma pentaphyllum, 30 parts of rhodiola rosea, 20 parts of astragalus membranaceus, 24 parts of stir-fried atractylodes macrocephala and 5 parts of raw licorice.

[0076] Using this traditional Chinese medicine composition as the raw material, prepare the oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0077] Example 4

[0078] A traditional Chinese medicine composition for treating rhinitis, which includes by weight: 40 parts of stir-fried xanthium sibiricum, 40 parts of magnolia officinalis, 24 parts of angelica dahurica, 30 parts of dandelion, 10 parts of gynostemma pentaphyllum, 30 parts of rhodiola rosea, 10 parts of astragalus membranaceus, 12 parts of stir-fried atractylodes macrocephala and 5 parts of raw licorice.

[0079] Using this traditional Chinese medicine composition as the raw material, prepare the oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0080] Example 5

[0081] A traditional Chinese medicine composition for treating rhinitis, which includes by weight: 40 parts of stir-fried xanthium sibiricum, 40 parts of magnolia officinalis, 24 parts of angelica dahurica, 30 parts of dandelion, 10 parts of gynostemma pentaphyllum, 15 parts of rhodiola rosea, 10 parts of astragalus membranaceus, 12 parts of stir-fried atractylodes macrocephala and 5 parts of raw licorice.

[0082] The Chinese medicine composition is used as a raw material to prepare an oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0083] Example 6

[0084] A traditional Chinese medicine composition for treating rhinitis comprises, by weight, 30 parts of stir-fried Xanthium sibiricum, 30 parts of Magnolia officinalis, 20 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 20 parts of Astragalus, 24 parts of stir-fried Atractylodes macrocephala and 10 parts of raw Licorice.

[0085] The Chinese medicine composition is used as a raw material to prepare an oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0086] Example 7

[0087] A traditional Chinese medicine composition for treating rhinitis comprises, by weight, 30 parts of stir-fried Xanthium sibiricum, 30 parts of Magnolia officinalis, 20 parts of Angelica dahurica, 15 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 20 parts of Rhodiola rosea, 20 parts of Astragalus, 24 parts of stir-fried Atractylodes macrocephala and 10 parts of raw Licorice.

[0088] The Chinese medicine composition is used as a raw material to prepare an oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0089] Example 8

[0090] A traditional Chinese medicine composition for treating rhinitis comprises, by weight, 20 parts of stir-fried Xanthium sibiricum, 20 parts of Magnolia officinalis, 12 parts of Angelica dahurica, 15 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 15 parts of Rhodiola rosea, 10 parts of Astragalus, 12 parts of stir-fried Atractylodes macrocephala and 2 parts of raw liquorice.

[0091] The Chinese medicine composition is used as a raw material to prepare an oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0092] Example 9

[0093] A traditional Chinese medicine composition for treating rhinitis comprises, by weight, 20 parts of stir-fried Xanthium sibiricum, 20 parts of Magnolia officinalis, 12 parts of Angelica dahurica, 15 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 20 parts of Astragalus, 20 parts of stir-fried Atractylodes macrocephala and 5 parts of raw liquorice.

[0094] The Chinese medicine composition is used as a raw material to prepare an oral liquid for treating rhinitis, and the preparation method is the same as that in Example 1.

[0095] Example 10

[0096] A traditional Chinese medicine composition for treating rhinitis comprises, by weight, 10 parts of stir-fried Xanthium sibiricum, 30 parts of Magnolia officinalis, 30 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 20 parts of Astragalus, 20 parts of stir-fried Atractylodes macrocephala and 5 parts of raw liquorice.

[0097] Using this traditional Chinese medicine composition as the raw material, an oral liquid for treating rhinitis is prepared, and the preparation method is the same as that in Example 1.

[0098] Example 11

[0099] A traditional Chinese medicine composition for treating rhinitis, which includes, by weight parts: 10 parts of stir-fried Xanthium sibiricum, 10 parts of Magnolia officinalis, 10 parts of Angelica dahurica, 10 parts of Taraxacum mongolicum, 20 parts of Gynostemma pentaphyllum, 20 parts of Rhodiola rosea, 20 parts of Astragalus membranaceus, 30 parts of stir-fried Atractylodes macrocephala and 5 parts of raw Glycyrrhiza uralensis.

[0100] Using this traditional Chinese medicine composition as the raw material, an oral liquid for treating rhinitis is prepared, and the preparation method is the same as that in Example 1.

[0101] Example 12

[0102] A traditional Chinese medicine composition for treating rhinitis, which includes, by weight parts: 10 parts of stir-fried Xanthium sibiricum, 10 parts of Magnolia officinalis, 20 parts of Angelica dahurica, 10 parts of Taraxacum mongolicum, 10 parts of Gynostemma pentaphyllum, 20 parts of Rhodiola rosea, 20 parts of Astragalus membranaceus, 20 parts of stir-fried Atractylodes macrocephala and 5 parts of raw Glycyrrhiza uralensis.

[0103] Using this traditional Chinese medicine composition as the raw material, an oral liquid for treating rhinitis is prepared, and the preparation method is the same as that in Example 1.

[0104] Effect Example

[0105] (1) Evaluation criteria:

[0106] ① Symptom grading evaluation

[0107] Table 1 Symptom grading quantitative scoring table

[0108]

[0109] ② Efficacy evaluation

[0110] Ineffective: (Total score of physical signs before treatment - Total score of physical signs after treatment) / (Total score of physical signs before treatment) * 100% ≤ 50%;

[0111] Effective: 50% < (Total score of physical signs before treatment - Total score of physical signs after treatment) / (Total score of physical signs before treatment) * 100% ≤ 75%;

[0112] Cured: (Total score of physical signs before treatment - Total score of physical signs after treatment) / (Total score of physical signs before treatment) * 100% > 75%.

[0113] The above "total score" refers to the sum of the scores corresponding to each symptom in Table 1.

[0114] (2) Experimental method:

[0115] Select rhinitis patients, and before treatment, grade the patients' symptoms according to the evaluation criteria shown in Table 1. Treat the patients with the oral liquid of the specific embodiment of the present invention, and then grade the patients' symptoms again according to Table 1. Finally, conduct the efficacy evaluation described in evaluation criterion ②.

[0116] (3) Specific cases:

[0117] ① Treat with the oral liquid of Example 3

[0118] Rhinitis patients numbered 1 - 15 took the oral liquid of Example 3 for treatment, 3 times a day, 10 mL orally each time. The specific symptoms and curative effects are shown in Table 2:

[0119] ② Treat with the oral liquid of Example 11

[0120] The rhinitis patient numbered 16 took the oral liquid of Example 11 for treatment, 3 times a day, 10 mL orally each time. The specific symptoms and curative effects are shown in Table 2:

[0121] ③ Treat with the oral liquid of Example 12

[0122] The rhinitis patient numbered 17 took the oral liquid of Example 12 for treatment, 3 times a day, 10 mL orally each time. The specific symptoms and curative effects are shown in Table 2:

[0123] Table 2 Summary table of patients' treatment conditions

[0124]

[0125]

[0126]

[0127] From the above experimental results, it can be concluded that the present invention has a good improvement effect on the symptoms of patients such as runny nose, nasal itching, nasal congestion, sneezing and headache, with a high total effective rate, obvious treatment effect, and can effectively inhibit the recurrence rate of rhinitis.

[0128] In the above text, the present invention has been described in detail with general descriptions and specific implementation examples. For those skilled in the art, modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection required by the present invention.

Claims

1. A Chinese medicine composition for treating rhinitis, It is characterized in that The invention comprises the following components by weight: 10-45 parts of stir-fried Xanthium sibiricum, 10-45 parts of Magnolia officinalis, 10-30 parts of Angelica dahurica, 10-35 parts of Taraxacum officinale, 5-20 parts of Gynostemma pentaphyllum, 10-35 parts of Rhodiola rosea, 10-30 parts of Astragalus, 10-30 parts of stir-fried Atractylodes macrocephala and 2-10 parts of raw Licorice root.

2. The Chinese medicine composition for treating rhinitis according to claim 1, It is characterized in that The invention comprises the following components by weight: 10-45 parts of stir-fried Xanthium sibiricum, 20-45 parts of Magnolia officinalis, 12-30 parts of Angelica dahurica, 15-35 parts of Taraxacum officinale, 10-20 parts of Gynostemma pentaphyllum, 15-35 parts of Rhodiola rosea, 10-30 parts of Astragalus, 12-30 parts of stir-fried Atractylodes macrocephala and 2-10 parts of raw Licorice root.

3. The Chinese medicine composition for treating rhinitis according to claim 2, It is characterized in that The invention comprises the following components by weight: 20-40 parts of stir-fried Xanthium sibiricum, 20-40 parts of Magnolia officinalis, 20-30 parts of Angelica dahurica, 15-30 parts of Taraxacum officinale, 10-20 parts of Gynostemma pentaphyllum, 20-30 parts of Rhodiola rosea, 10-20 parts of Astragalus, 12-24 parts of stir-fried Atractylodes macrocephala and 5-10 parts of raw Licorice root.

4. The Chinese medicine composition for treating rhinitis according to claim 1, It is characterized in that The invention is composed of the following components by weight: 45 parts of stir-fried Xanthium sibiricum, 45 parts of Magnolia officinalis, 30 parts of Angelica dahurica, 35 parts of Taraxacum officinale, 20 parts of Gynostemma pentaphyllum, 35 parts of Rhodiola rosea, 30 parts of Astragalus, 30 parts of stir-fried Atractylodes macrocephala and 10 parts of raw Licorice root; Or, it is composed of the following components by weight: 45 parts of stir-fried Xanthium sibiricum, 45 parts of Magnolia officinalis, 30 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 20 parts of Astragalus, 20 parts of stir-fried Atractylodes macrocephala and 8 parts of raw Licorice; Or, it is composed of the following components by weight: 40 parts of stir-fried Xanthium sibiricum, 40 parts of Magnolia officinalis, 24 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 20 parts of Astragalus, 24 parts of stir-fried Atractylodes macrocephala and 5 parts of raw Licorice; Or, it is composed of the following components by weight: 40 parts of stir-fried Xanthium sibiricum, 40 parts of Magnolia officinalis, 24 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 10 parts of Astragalus, 12 parts of stir-fried Atractylodes macrocephala and 5 parts of raw Licorice; Or, it is composed of the following components by weight: 40 parts of stir-fried Xanthium sibiricum, 40 parts of Magnolia officinalis, 24 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 15 parts of Rhodiola rosea, 10 parts of Astragalus, 12 parts of stir-fried Atractylodes macrocephala and 5 parts of raw Licorice; Or, it is composed of the following components by weight: 30 parts of stir-fried Xanthium sibiricum, 30 parts of Magnolia officinalis, 20 parts of Angelica dahurica, 30 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 30 parts of Rhodiola rosea, 20 parts of Astragalus, 24 parts of stir-fried Atractylodes macrocephala and 10 parts of raw Licorice; Or, it is composed of the following components by weight: 30 parts of stir-fried Xanthium sibiricum, 30 parts of Magnolia officinalis, 20 parts of Angelica dahurica, 15 parts of Taraxacum officinale, 10 parts of Gynostemma pentaphyllum, 20 parts of Rhodiola rosea, 20 parts of Astragalus, 24 parts of stir-fried Atractylodes macrocephala and 10 parts of raw Licorice; Or, it is composed of the following components by weight parts: stir-fried Xanthii Fructus 20 parts, Magnoliae Flos 20 parts, Angelicae Dahuricae Radix 12 parts, Taraxaci Herba 15 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 15 parts, Astragali Radix 10 parts, stir-fried Atractylodis Macrocephalae Rhizoma 12 parts, and Glycyrrhizae Radix Preparata 2 parts; Or, it is composed of the following components by weight parts: stir-fried Xanthii Fructus 20 parts, Magnoliae Flos 20 parts, Angelicae Dahuricae Radix 12 parts, Taraxaci Herba 15 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix Preparata 5 parts; Or, it is composed of the following components by weight parts: stir-fried Xanthii Fructus 10 parts, Magnoliae Flos 30 parts, Angelicae Dahuricae Radix 30 parts, Taraxaci Herba 30 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 30 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix Preparata 5 parts; Or, it is composed of the following components by weight parts: stir-fried Xanthii Fructus 10 parts, Magnoliae Flos 10 parts, Angelicae Dahuricae Radix 10 parts, Taraxaci Herba 10 parts, Gynostemmae Pentaphylli Herba 20 parts, Rhodiolae Roseae Radix 20 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 30 parts, and Glycyrrhizae Radix Preparata 5 parts; Or, it is composed of the following components by weight parts: stir-fried Xanthii Fructus 10 parts, Magnoliae Flos 10 parts, Angelicae Dahuricae Radix 20 parts, Taraxaci Herba 10 parts, Gynostemmae Pentaphylli Herba 10 parts, Rhodiolae Roseae Radix 20 parts, Astragali Radix 20 parts, stir-fried Atractylodis Macrocephalae Rhizoma 20 parts, and Glycyrrhizae Radix Preparata 5 parts.

5. A preparation method of an oral liquid for treating rhinitis, characterized in that, it uses the traditional Chinese medicine composition for treating rhinitis described in any one of claims 1-4 as raw materials, and includes the following steps: S1: Distill Magnoliae Flos to obtain Magnoliae Flos distillate; S2: Add the other components except Magnoliae Flos in the traditional Chinese medicine composition for treating rhinitis to the Magnoliae Flos residue obtained in step S1, decoct with water, and concentrate to obtain a first concentrated liquid; add an ethanol aqueous solution to the first concentrated liquid, and concentrate under reduced pressure to obtain a second concentrated liquid; add water to the second concentrated liquid, filter, and collect the filtrate; S3: Mix the filtrate obtained in step S2 and the Magnoliae Flos distillate obtained in step S1 to obtain a mixed liquid, filter, and boil and sterilize.

6. The preparation method of the oral liquid for treating rhinitis according to claim 5, characterized in that, in step S1, the distillation operation includes soaking in water for 24 hours first, and then extracting at a slightly boiling state for 8 hours; and / or, in step S2, the decoction is carried out twice, each time for 2 hours; and / or, in step S2, the volume fraction of ethanol in the ethanol aqueous solution is 50% - 80%; and / or, in step S2, the volume ratio of the first concentrated liquid to the ethanol aqueous solution is 1:(5 - 20); and / or, add distilled water to the second concentrated liquid.

7. The preparation method of the oral liquid for treating rhinitis according to claim 6, characterized in that, in step S2, the volume fraction of ethanol in the ethanol aqueous solution is 65%.

8. The preparation method of the oral liquid for treating rhinitis according to claim 6, characterized in that, in step S2, the volume ratio of the first concentrated liquid to the ethanol aqueous solution is 1:

10.

9. The preparation method of the oral liquid for treating rhinitis according to claim 5, characterized in that, after adding the ethanol aqueous solution to the first concentrated liquid in step S2, it further includes the steps of standing and refrigerating; And / or, in step S2, after adding water to the secondary concentrated solution, a refrigeration step is further included.

10. The method for preparing the oral liquid for treating rhinitis according to claim 5, wherein, in step S2, after adding an ethanol aqueous solution to the primary concentrated solution, a standing and refrigeration step are further included; wherein, the refrigeration is at 2-10°C for 48 hours.

11. The method for preparing the oral liquid for treating rhinitis according to claim 5, wherein, in step S2, after adding water to the secondary concentrated solution, a refrigeration step is further included; wherein, the refrigeration is at 2-10°C for 48 hours.

12. The method for preparing the oral liquid for treating rhinitis according to claim 5, wherein, in step S3, adding excipients and / or water to the mixed solution is further included.

13. The method for preparing the oral liquid for treating rhinitis according to claim 12, wherein, the excipients are sweeteners and / or preservatives.

14. The method for preparing the oral liquid for treating rhinitis according to claim 13, wherein, the sweetener is white granulated sugar.

15. The method for preparing the oral liquid for treating rhinitis according to claim 13, wherein, the preservative is sodium benzoate.

16. The method for preparing the oral liquid for treating rhinitis according to claim 12, wherein, the water is purified water.

17. An oral liquid for treating rhinitis, wherein, it is prepared by using the method for preparing the oral liquid for treating rhinitis according to any one of claims 5-16.

18. The application of a traditional Chinese medicine composition for treating rhinitis according to any one of claims 1-4 or the oral liquid for treating rhinitis according to claim 17 in the preparation of a drug for treating rhinitis.

Images