A method for preparing trifluoromethyl-containing pyridine derivatives based on fluoroform

CN117417294BActive Publication Date: 2026-08-28SHAANXI UNIV OF SCI & TECH
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Patent Information

Application Number
CN202311426711.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-10-30
Publication Date
2026-08-28
Estimated Expiration
2043-10-30

AI Technical Summary

Technical Problem

[0004]为了克服上述现有技术的缺点，本发明的目的在于提供一种基于氟仿制备的含三氟甲基吡啶衍生物及方法，用以解决现有的制备方法存在较为复杂的操作步骤，较为苛刻的制备条件以及依赖较为昂贵的三氟甲基试剂的技术问题

Benefits of technology

[0018]本发明公开了一种基于氟仿制备含三氟甲基吡啶衍生物的方法，以硫氰酸亚铜、叔丁醇钾、DMF、三乙胺盐酸盐和含硼酸基吡啶衍生物作为反应原料，利用高温室气体氟仿与含硼酸基吡啶衍生物反应得到目标产物，这些化合物在医药领域有广泛地应用，提供的三氟甲基吡啶衍生物合成方法简单，反应条件温和，实现高温室气体氟仿的高值利用等特点。

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Abstract

The application discloses a kind of preparation based on fluorine imitation containing trifluoromethyl pyridine derivatives and method, belong to the technical field of pharmaceutical intermediates preparation.The method disclosed in the application utilizes high-temperature greenhouse gas fluorine imitation and reacts with pyridine derivative containing boronic acid group to obtain target product, and these compounds have wide application in the field of medicine.The trifluoromethyl pyridine derivative synthesis method provided by the application has the advantages such as simple method, mild reaction condition, high-value utilization of high-temperature greenhouse gas fluorine imitation, and has wide application prospect.
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Citation Information

Patent Citations

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  • Preparation method of 3-chloro-4-iodine-2-tirfluoromethylpyridine

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