Neutral calcium supplement preparation

Abstract

The invention relates to the technical field of medicines, in particular to a neutral calcium supplement preparation. The neutral calcium supplement preparation is prepared from the following raw materials in parts by weight: 20-30 parts of a calcium source, 3-6 parts of multivitamins, 3-5 parts of corn starch, 2-4 parts of magnesium stearate, 4-7 parts of mannitol and 2-5 parts of a flavoring agent, the neutral calcium supplement preparation is prepared by taking a calcium source, multivitamins, corn starch, magnesium stearate, mannitol, a flavoring agent and the like as raw materials. The neutral calcium supplement preparation prepared by the invention not only has better solubility, can relieve the burden of the stomach, but also has excellent easy-to-absorb performance, is convenient to absorb by a human body and has no toxic or side effect, and the quality of the neutral calcium supplement preparation is effectively ensured.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, in particular to a neutral calcium supplement preparation. Background Art

[0002] Calcium is the main component of bones and teeth. 99% of the calcium in the body is in the bones, and 1% is distributed in the body fluids, maintaining normal nerve excitability and electrophysiological activity of the heart. Therefore, calcium has a very important physiological role and can maintain normal permeability of blood vessels. When the calcium content in body fluids decreases, especially when calcium is deficient, the permeability of capillaries will increase, allowing more water in the blood to penetrate into the extravascular tissues. This is also the pathogenesis of certain allergic diseases. At the same time, when allergic edema occurs, calcium supplements can effectively relieve these symptoms. In particular, the problem of calcium deficiency in women, children and the elderly has attracted widespread attention from the society. Effective calcium supplementation is not only a treatment for calcium deficiency and osteoporosis, but also the main means to prevent the occurrence of calcium deficiency.

[0003] At present, the calcium absorption rate of common calcium tablets is low, and a lot of supplemented calcium will be lost in vain; if the unabsorbed calcium cannot be excreted from the body in time, it is of great significance to improve the calcium absorption rate. In addition, many elderly people have a gradual decline in digestive system function, which reduces the secretion of digestive juices and causes a lack of gastric acid, which further affects the absorption of calcium. Some elderly people even experience nausea after taking calcium tablets. Therefore, promoting the secretion of digestive juices while supplementing calcium and promoting absorption is a more suitable method of calcium supplementation for the elderly.

[0004] Based on this, the present invention provides a neutral calcium supplement preparation to solve the above-mentioned technical problems! Summary of the invention

[0005] The purpose of the present invention is to provide a neutral calcium supplement preparation, and the prepared high-altitude light-transmitting projectable ceiling soft film not only has good mechanical properties, but also has excellent flame retardant properties, effectively ensuring its quality.

[0006] To achieve the above object, the present invention provides the following technical solutions:

[0007] The present invention provides a neutral calcium supplement preparation, which is composed of the following raw materials in parts by weight: 20 to 30 parts of calcium source, 3 to 6 parts of complex vitamins, 3 to 5 parts of corn starch, 2 to 4 parts of magnesium stearate, 4 to 7 parts of mannitol and 2 to 5 parts of flavoring agent;

[0008] The preparation process of the neutral calcium supplement preparation is as follows:

[0009] Step 1, accurately weighing the calcium source, multivitamins, corn starch, magnesium stearate, mannitol and flavoring agent, placing the corn starch in 2 to 4 times the mass of deionized water, stirring at 320 to 340 r / min for 2 to 5 minutes, then adding the flavoring agent thereto, and continuing stirring for 1 to 3 minutes to obtain a premix;

[0010] Step 2, add the calcium source, the multivitamin, and the mannitol into the wet granulator in order, dry mix for 12 to 22 minutes, add the premix, stir for 8 to 12 minutes at 50 to 60 r / min, stir for 15 to 20 minutes at 450 to 550 r / min, wet mix for 5 to 10 seconds, stir evenly, and then discharge to prepare wet granules of 12 to 14 meshes, dry at 50 to 60° C. for 30 to 40 minutes, take out, and prepare premixed granules;

[0011] Step 3: Add the premixed granules and magnesium stearate into a mixer, mix at 20 to 25 r / min for 10 to 18 minutes, and then tablet press to prepare a neutral calcium supplement preparation.

[0012] The present invention is further configured as follows: the calcium source is prepared by mixing composite calcium and cod bone extract in a mass ratio of 1:0.1-0.3.

[0013] The present invention is further configured as follows: the preparation process of the composite calcium is as follows:

[0014] The sheep bone powder is ultrasonically dispersed in deionized water at a dosage of 0.02-0.08 g / mL for 20-30 minutes, the pH is adjusted to 7.5-8.0 with a sodium hydroxide solution, the temperature is raised to 50-55° C., 2.1-2.4% alkaline protease by weight of the sheep bone powder is added thereto, enzymolysis is performed for 100-120 minutes, sterilization is performed, and freeze-drying is performed to obtain a base material;

[0015] The base material is placed in deionized water for ultrasonic dispersion for 20 to 30 minutes at a dosage ratio of 0.02 to 0.12 g / mL, and calcium powder of 200 to 240% of the mass of the base material is added thereto, and the mixture is treated at a temperature of 40 to 50° C. for 40 to 46 minutes, cooled to room temperature, filtered, sterilized, and freeze-dried to obtain composite calcium.

[0016] The present invention is further configured as follows: the calcium powder is selected from any one of calcium chloride and calcium carbonate.

[0017] The present invention is further configured as follows: the preparation process of the cod bone extract is as follows:

[0018] The cod bones are placed in a sodium chloride solution with a concentration of 2.6-2.8% at a dosage ratio of 0.005-0.01 g / mL, treated at 2-3° C. for 300-320 min, filtered, washed with deionized water 2-4 times, and dried at 55-65° C. to constant weight to obtain a first product;

[0019] The cod bones are placed in an isopropanol solution with a concentration of 11 to 13% at a dosage ratio of 0.002 to 0.08 g / mL, treated at 5 to 7° C. for 200 to 240 minutes, filtered, washed with deionized water for 2 to 4 times, and dried at 55 to 65° C. to constant weight to obtain a second product;

[0020] The second product is crushed into 60-80 meshes to obtain cod bone powder, and the cod bone powder is placed in a hydrochloric acid solution with a concentration of 8-9% at a dosage ratio of 0.12-0.24 g / mL, and extracted at 46-50° C. for 70-90 min. The obtained extraction product is centrifuged at 8000-10000 r / min for 30-40 min, and the obtained centrifuged product is dried at a temperature of 55-65° C. to constant weight to obtain a cod bone extract.

[0021] The present invention is further configured as follows: the compound vitamin is formed by mixing vitamin C and vitamin D in a mass ratio of 1:0.5-0.8.

[0022] The present invention is further configured as follows: the flavoring agent is selected from any one of citric acid, tartaric acid and malic acid.

[0023] The present invention is further configured as follows: the tabletting pressure is 3.0-5.0 MPa.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] The present invention uses calcium source, multivitamins, corn starch, magnesium stearate, mannitol and flavoring agent as raw materials, corn starch is placed in deionized water and stirred, and then flavoring agent is added thereto, and stirring is continued to obtain a premix, and the calcium source, multivitamins, and mannitol are added to the wet granulator in order in sequence by igniting a fire, and the premix is ​​added after dry mixing, and stirred at low speed and high speed, and then wet mixing is stirred and uniformly discharged to make wet granules, and after drying, the premixed granules are taken out to prepare the premixed granules, and finally the premixed granules and magnesium stearate are put into the mixer for mixing, and tableting is performed to prepare the neutral calcium supplement preparation. The neutral calcium supplement preparation prepared by the present invention not only has good solubility and can reduce the burden of the stomach, but also has excellent easy absorption performance, is convenient for human body absorption, has no toxic side effects, and effectively guarantees its quality and quality. The neutral calcium supplement preparation provided by the present invention has a broader market prospect and is more suitable for promotion. DETAILED DESCRIPTION

[0026] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Example 1

[0028] This embodiment provides a neutral calcium supplement preparation, which is composed of the following raw materials in parts by weight: 20 parts of calcium source, 3 parts of complex vitamins, 3 parts of corn starch, 2 parts of magnesium stearate, 4 parts of mannitol and 2 parts of flavoring agent.

[0029] The calcium source is prepared by mixing complex calcium and cod bone extract in a mass ratio of 1:0.1.

[0030] Further, the preparation process of composite calcium is as follows:

[0031] The sheep bone powder was ultrasonically dispersed in deionized water at a dosage of 0.02 g / mL for 20 minutes, the pH was adjusted to 7.5 with a sodium hydroxide solution, the temperature was raised to 50° C., 2.1% alkaline protease by mass of the sheep bone powder was added thereto, and after enzymolysis for 100 minutes, the base material was sterilized and freeze-dried to obtain the base material;

[0032] The base material was ultrasonically dispersed in deionized water at a dosage ratio of 0.02 g / mL for 20 minutes, 200% of the mass of the base material of calcium powder was added thereto, the mixture was treated at 40° C. for 40 minutes, cooled to room temperature, filtered, sterilized, and freeze-dried to obtain composite calcium.

[0033] In this example, it should be noted that alkaline protease was purchased from Nanning Dongheng Huadao Biotechnology Co., Ltd. (Alcalase 2.4L).

[0034] Furthermore, the calcium powder is calcium chloride.

[0035] Furthermore, the preparation process of cod bone extract is as follows:

[0036] The cod bones were placed in a 2.6% sodium chloride solution at a dosage ratio of 0.005 g / mL, treated at 2° C. for 300 min, filtered, washed twice with deionized water, and dried at 55° C. to constant weight to obtain a first product;

[0037] The cod bones were placed in an isopropanol solution with a concentration of 11-13% at a dosage ratio of 0.002 g / mL, treated at 5° C. for 200 min, filtered, washed twice with deionized water, and dried at 55° C. to constant weight to obtain a second product;

[0038] The second product was crushed into 60 mesh to obtain cod bone powder, and the cod bone powder was placed in a hydrochloric acid solution with a concentration of 8% at a dosage ratio of 0.12 g / mL, and extracted at 46° C. for 70 min. The obtained extract was centrifuged at 8000 r / min for 30 min, and the obtained centrifuged product was dried to constant weight at 55° C. to obtain a cod bone extract.

[0039] Among them, the multivitamin is a mixture of vitamin C and vitamin D in a mass ratio of 1:0.5.

[0040] Citric acid is used as flavoring agent.

[0041] In addition, this embodiment also provides the preparation process of the above-mentioned neutral calcium supplement preparation as follows:

[0042] Step 1: accurately weigh the calcium source, multivitamins, corn starch, magnesium stearate, mannitol and flavoring agent, place the corn starch in deionized water twice its mass, stir at 320 r / min for 2 min, add the flavoring agent thereto, and continue stirring for 1 min to obtain a premix;

[0043] Step 2, add the calcium source, multivitamin, and mannitol into the wet granulator in order, dry mix for 12 minutes, add the premix, stir for 8 minutes at 50r / min, stir for 15 minutes at 450r / min, wet mix for 5s, stir evenly, and then discharge to make 12-mesh wet granules, dry at 50°C for 30 minutes, take out, and prepare premixed granules;

[0044] Step 3: Add the premixed granules and magnesium stearate into a mixer, mix at 20 r / min for 10 min, and then tablet press to prepare a neutral calcium supplement preparation.

[0045] Among them, the tableting pressure is 3.0MP.

[0046] Example 2

[0047] This embodiment provides a neutral calcium supplement preparation, which is composed of the following raw materials in parts by weight: 25 parts of calcium source, 4 parts of complex vitamins, 4 parts of corn starch, 3 parts of magnesium stearate, 5 parts of mannitol and 3 parts of flavoring agent.

[0048] The calcium source is prepared by mixing complex calcium and cod bone extract in a mass ratio of 1:0.2.

[0049] Further, the preparation process of composite calcium is as follows:

[0050] The sheep bone powder was ultrasonically dispersed in deionized water at a dosage of 0.05 g / mL for 25 minutes, the pH was adjusted to 7.7 with a sodium hydroxide solution, the temperature was raised to 52° C., 2.3% alkaline protease by weight of the sheep bone powder was added thereto, and after enzymolysis for 110 minutes, the base material was sterilized and freeze-dried to obtain the base material;

[0051] The base material was ultrasonically dispersed in deionized water at a dosage ratio of 0.07 g / mL for 25 minutes, and calcium powder accounting for 220% of the base material's mass was added thereto. The mixture was treated at 45° C. for 43 minutes, cooled to room temperature, filtered, sterilized, and freeze-dried to obtain composite calcium.

[0052] In this example, it should be noted that alkaline protease was purchased from Nanning Dongheng Huadao Biotechnology Co., Ltd. (Alcalase 2.4L).

[0053] Furthermore, the calcium powder is calcium chloride.

[0054] Furthermore, the preparation process of cod bone extract is as follows:

[0055] The cod bones were placed in a 2.7% sodium chloride solution at a dosage ratio of 0.007 g / mL, treated at 3° C. for 310 min, filtered, washed with deionized water for 3 times, and dried at 60° C. to constant weight to obtain a first product;

[0056] The cod bones were placed in a 12% isopropanol solution at a dosage ratio of 0.048 g / mL, treated at 6° C. for 220 min, filtered, washed with deionized water for 3 times, and dried at 60° C. to constant weight to obtain a second product;

[0057] The second product was crushed into 70 meshes to obtain cod bone powder, and the cod bone powder was placed in a 9% hydrochloric acid solution at a dosage ratio of 0.18 g / mL, and extracted at 48° C. for 80 min. The obtained extract was centrifuged at 9000 r / min for 35 min, and the obtained centrifuged product was dried to constant weight at 60° C. to obtain a cod bone extract.

[0058] Among them, the multivitamin is a mixture of vitamin C and vitamin D in a mass ratio of 1:0.7.

[0059] Tartaric acid is used as the flavoring agent.

[0060] In addition, this embodiment also provides the preparation process of the above-mentioned neutral calcium supplement preparation as follows:

[0061] Step 1: accurately weigh the calcium source, multivitamins, corn starch, magnesium stearate, mannitol and flavoring agent, place the corn starch in 3 times the mass of deionized water, stir at 330 r / min for 4 min, then add the flavoring agent thereto, continue stirring for 2 min, and obtain a premix;

[0062] Step 2: Add the calcium source, multivitamins and mannitol to the wet granulator in order, dry mix for 17 minutes, add the premix, stir for 10 minutes at 55 r / min, stir for 17 minutes at 500 r / min, wet mix for 7 seconds, stir evenly and then discharge to make 13-mesh wet granules, dry at 55° C. for 35 minutes, take out and prepare premixed granules;

[0063] Step 3: Add the premixed granules and magnesium stearate into a mixer, mix at 22 r / min for 14 min, and then tablet press to prepare a neutral calcium supplement preparation.

[0064] Among them, the tableting pressure is 4.0MP.

[0065] Example 3

[0066] This embodiment provides a neutral calcium supplement preparation, which is composed of the following raw materials in parts by weight: 30 parts of calcium source, 6 parts of complex vitamins, 5 parts of corn starch, 4 parts of magnesium stearate, 7 parts of mannitol and 5 parts of flavoring agent.

[0067] The calcium source is a mixture of complex calcium and cod bone extract in a mass ratio of 1:0.3.

[0068] Further, the preparation process of composite calcium is as follows:

[0069] The sheep bone powder was ultrasonically dispersed in deionized water at a dosage of 0.08 g / mL for 30 minutes, the pH was adjusted to 8.0 with a sodium hydroxide solution, the temperature was raised to 55° C., 2.4% alkaline protease by weight of the sheep bone powder was added thereto, and after enzymolysis for 120 minutes, the base material was sterilized and freeze-dried to obtain the base material;

[0070] The base material was ultrasonically dispersed in deionized water at a dosage ratio of 0.12 g / mL for 30 minutes, and calcium powder accounting for 240% of the mass of the base material was added thereto. The mixture was treated at 50° C. for 46 minutes, cooled to room temperature, filtered, sterilized, and freeze-dried to obtain composite calcium.

[0071] In this example, it should be noted that alkaline protease was purchased from Nanning Dongheng Huadao Biotechnology Co., Ltd. (Alcalase 2.4L).

[0072] Furthermore, the calcium powder is calcium carbonate.

[0073] Furthermore, the preparation process of cod bone extract is as follows:

[0074] The cod bones were placed in a 2.8% sodium chloride solution at a dosage ratio of 0.01 g / mL, treated at 3° C. for 320 min, filtered, washed with deionized water 4 times, and dried at 65° C. to constant weight to obtain a first product;

[0075] The cod bones were placed in a 13% isopropanol solution at a dosage ratio of 0.08 g / mL, treated at 7° C. for 240 min, filtered, washed with deionized water 4 times, and dried at 65° C. to constant weight to obtain a second product;

[0076] The second product was crushed into 80 meshes to obtain cod bone powder, and the cod bone powder was placed in a 9% hydrochloric acid solution at a dosage ratio of 0.24 g / mL, and extracted at 50° C. for 90 min. The obtained extract was centrifuged at 10,000 r / min for 40 min, and the obtained centrifuged product was dried at 65° C. to constant weight to obtain a cod bone extract.

[0077] Among them, the multivitamin is a mixture of vitamin C and vitamin D in a mass ratio of 1:0.8.

[0078] Malic acid is used as the flavoring agent.

[0079] In addition, this embodiment also provides the preparation process of the above-mentioned neutral calcium supplement preparation as follows:

[0080] Step 1: accurately weigh the calcium source, multivitamins, corn starch, magnesium stearate, mannitol and flavoring agent, place the corn starch in deionized water 4 times its mass, stir at 340 r / min for 5 min, add the flavoring agent thereto, and continue stirring for 3 min to obtain a premix;

[0081] Step 2, add the calcium source, multivitamin, and mannitol into the wet granulator in order, dry mix for 22 minutes, add the premix, stir for 12 minutes at 60r / min, stir for 20 minutes at 550r / min, wet mix for 10s, stir evenly, and then discharge to make 14-mesh wet granules, dry at 60°C for 40 minutes, take out, and prepare premixed granules;

[0082] Step 3: Add the premixed granules and magnesium stearate into a mixer, mix at 25 r / min for 18 min, and then tablet press to prepare a neutral calcium supplement preparation.

[0083] The tableting pressure is 5.0 MPa.

[0084] Performance test: The neutral calcium supplement preparations provided in Examples 1 to 3 are respectively marked as Examples 1 to 3; and the relevant performances of the neutral calcium supplement preparations provided in Examples 1 to 3 are respectively tested as follows:

[0085] 1. Safety test:

[0086] Experimental animals: Kunming white mice, 18-22 g, 30 mice, half male and half female;

[0087] Feeding conditions: After entering the laboratory, the animals were raised for one week before use. They were managed by a dedicated person. The feeding room had sufficient light, ventilation and air conditioning equipment, room temperature of 18-25℃, humidity of 50.70%, 10 mice per cage, and males and females were raised separately.

[0088] Dosage setting: 50 g / kg / d;

[0089] Experimental method: Gavage once a day, observe changes in appearance and behavior and count the number of animal deaths within one week.

[0090] 2. Solubility test:

[0091] Each group of neutral calcium supplements was injected into pure water and soaked for 70 minutes, and then a conductivity experiment was conducted.

[0092] 3. Absorption performance test:

[0093] 40 male clean mice weighing 20±2g were prepared and randomly divided into 4 groups. Each group had 10 mice. After 3 days of adaptive feeding, the mice were gavaged with the neutral calcium supplement preparations of Examples 1 to 3 once a day at a specification of 0.005g / 20g. During the feeding process, the mice were fed with deionized water to avoid obtaining calcium from drinking water. The calcium absorption rate and bone calcium content were detected by atomic absorption spectrophotometry.

[0094] The obtained test data are recorded in Tables 1 and 2 below:

[0095] Table 1 Safety performance test results of each group

[0096] Group Behavioral status Number of deaths Example 1 Group Normal behavior 0 Example 2 Group Normal behavior 0 Example 3 Group Normal behavior 0

[0097] Table 2 Solubility test results of each group

[0098]

[0099]

[0100] Table 3 Absorption performance test results of each group

[0101] Group Calcium absorption rate (%) Bone calcium content (%) Example 1 Group 97.2 3.71 Example 2 Group 96.9 3.65 Example 3 Group 97.0 3.68

[0102] By comparing and analyzing the relevant data in Tables 1 to 3, it can be seen that the neutral calcium supplement preparation prepared by the present invention not only has good solubility and can reduce the burden on the stomach, but also has excellent easy absorption performance, is easy for human body to absorb, has no toxic side effects, and effectively guarantees its quality. This shows that the neutral calcium supplement preparation provided by the present invention has a broader market prospect and is more suitable for promotion.

[0103] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0104] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A neutral calcium supplement preparation, characterized in that: The invention is composed of the following raw materials in parts by weight: 20 to 30 parts of calcium source, 3 to 6 parts of complex vitamins, 3 to 5 parts of corn starch, 2 to 4 parts of magnesium stearate, 4 to 7 parts of mannitol and 2 to 5 parts of flavoring agent; The preparation process of the neutral calcium supplement preparation is as follows: Step 1, accurately weighing the calcium source, multivitamins, corn starch, magnesium stearate, mannitol and flavoring agent, placing the corn starch in 2 to 4 times the mass of deionized water, stirring at 320 to 340 r / min for 2 to 5 minutes, then adding the flavoring agent thereto, and continuing stirring for 1 to 3 minutes to obtain a premix; Step 2, adding the calcium source, the multivitamin, and the mannitol into the wet granulator in sequence, dry mixing for 12 to 22 minutes, adding the premix, stirring for 8 to 12 minutes at 50 to 60 r / min, stirring for 15 to 20 minutes at 450 to 550 r / min, wet mixing for 5 to 10 seconds, stirring evenly, and then discharging to prepare wet granules of 12 to 14 meshes, drying at 50 to 60° C. for 30 to 40 minutes, taking out, and preparing premixed granules; Step 3: Add the premixed granules and magnesium stearate into a mixer, mix at 20 to 25 r / min for 10 to 18 minutes, and then tablet press to prepare a neutral calcium supplement preparation.

2. The neutral calcium supplement preparation according to claim 1, characterized in that: The calcium source is prepared by mixing composite calcium and cod bone extract in a mass ratio of 1:0.1-0.

3.

3. The neutral calcium supplement preparation according to claim 2, characterized in that: The preparation process of the composite calcium is as follows: The sheep bone powder is ultrasonically dispersed in deionized water at a dosage of 0.02-0.08 g / mL for 20-30 minutes, the pH is adjusted to 7.5-8.0 with a sodium hydroxide solution, the temperature is raised to 50-55° C., 2.1-2.4% alkaline protease by weight of the sheep bone powder is added thereto, enzymolysis is performed for 100-120 minutes, sterilization is performed, and freeze-drying is performed to obtain a base material; The base material is placed in deionized water for ultrasonic dispersion for 20 to 30 minutes at a dosage ratio of 0.02 to 0.12 g / mL, and calcium powder of 200 to 240% of the mass of the base material is added thereto, and the mixture is treated at a temperature of 40 to 50° C. for 40 to 46 minutes, cooled to room temperature, filtered, sterilized, and freeze-dried to obtain composite calcium.

4. The neutral calcium supplement preparation according to claim 3, characterized in that: The calcium powder can be any one of calcium chloride and calcium carbonate.

5. The neutral calcium supplement preparation according to claim 2, characterized in that: The preparation process of the cod bone extract is as follows: The cod bones are placed in a sodium chloride solution with a concentration of 2.6-2.8% at a dosage ratio of 0.005-0.01 g / mL, treated at 2-3° C. for 300-320 min, filtered, washed with deionized water 2-4 times, and dried at 55-65° C. to constant weight to obtain a first product; The cod bones are placed in an isopropanol solution with a concentration of 11 to 13% at a dosage ratio of 0.002 to 0.08 g / mL, treated at 5 to 7° C. for 200 to 240 minutes, filtered, washed with deionized water for 2 to 4 times, and dried at 55 to 65° C. to constant weight to obtain a second product; The second product is crushed into 60-80 meshes to obtain cod bone powder, and the cod bone powder is placed in a hydrochloric acid solution with a concentration of 8-9% at a dosage ratio of 0.12-0.24 g / mL, and extracted at 46-50° C. for 70-90 min. The obtained extraction product is centrifuged at 8000-10000 r / min for 30-40 min, and the obtained centrifuged product is dried at a temperature of 55-65° C. to constant weight to obtain a cod bone extract.

6. The neutral calcium supplement preparation according to claim 1, characterized in that: The compound vitamin is prepared by mixing vitamin C and vitamin D in a mass ratio of 1:0.5-0.

8.

7. The neutral calcium supplement preparation according to claim 1, characterized in that: The flavoring agent is selected from any one of citric acid, tartaric acid and malic acid.

8. The neutral calcium supplement preparation according to claim 1, characterized in that: The tabletting pressure is 3.0-5.0 MPa.

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