Composite fish oil emulsion for preventing cardiovascular diseases and preparation process thereof

Abstract

The invention discloses a compound fish oil emulsion for preventing cardiovascular diseases and a preparation process thereof, and relates to the technical field of fish oil emulsions. Comprising the following raw materials: fish oil, rice bran fatty alkanol, a blood protein peptide concentrated solution, red yeast rice, haws, lotus leaves, flammulina velutipes extract powder, sorbitol, glycerin, citric acid fatty acid ester, monoglyceride and diglyceride, sweet orange oil, lemon oil and vitamins. According to the compound fish oil emulsion for preventing cardiovascular diseases and the preparation process thereof, the fish oil is beneficial to blood fat regulation, the red yeast rice contains lovastatin and can reduce cholesterol, and the hawthorn and the lotus leaves assist in reducing blood fat and act together with the fish oil, so that the blood fat regulation effect is enhanced, the blood viscosity is reduced, and the risk of cardiovascular diseases is reduced; the fish oil provides Omega-3 fatty acid, the blood protein peptide concentrated solution provides protein, and the rice bran fatty alkanol has nutritional and health-care effects, so that the nutritional value of the product is increased through synergism of the fish oil, the blood protein peptide concentrated solution and the rice bran fatty alkanol, the human immunity is enhanced, and the body function is improved.

Description

Technical Field

[0001] The invention relates to the technical field of fish oil emulsions, in particular to a composite fish oil emulsion for preventing cardiovascular diseases and a preparation process thereof. Background Art

[0002] The Chinese patent with publication number CN1229652A discloses a composite fish oil that can prevent cardiovascular diastolic dysfunction and arteriosclerosis. The composite fish oil is composed of conventional fish oil and quercetin or quercetin and vitamin E. It can effectively prevent the oxidation of fish oil in the human body, protect and enhance the original main function of fish oil in regulating the balance of prostacyclin and thromboxane, and obtain a new function of preventing arteriosclerosis by protecting the oxidation tolerance of low-density lipoprotein and endothelial-dependent vasodilator factor. However, the composite fish oil prepared by the above-mentioned prior art solution still has a fishy smell, and its antioxidant performance needs to be further improved; for this reason, the present invention provides a composite fish oil emulsion for preventing cardiovascular diseases and its preparation process to solve the above problems. Summary of the invention

[0003] In view of the deficiencies of the prior art, the present invention provides a composite fish oil emulsion for preventing cardiovascular diseases and a preparation process thereof, which solves the problems mentioned in the above background technology.

[0004] To achieve the above objectives, the present invention is implemented through the following technical scheme: a composite fish oil emulsion for preventing cardiovascular diseases, comprising the following raw materials: fish oil, rice bran fatty alkyl alcohol, hemoprotein peptide concentrate, red yeast rice, hawthorn, lotus leaf, enoki mushroom extract powder, sorbitol, glycerol, citric acid fatty acid esters, mono- and di-glycerides, sweet orange oil, lemon oil, and vitamins.

[0005] Preferably, the composite fish oil emulsion for preventing cardiovascular diseases further comprises the following auxiliary materials: antioxidant, emulsifier, pH regulator and sweetener.

[0006] Preferably, the antioxidant is a combination of tea polyphenols, soybean lecithin and ascorbic acid; the emulsifier is selected from one or more of soybean lecithin, sucrose fatty acid ester, polyglycerol fatty acid ester and egg yolk lecithin; the pH regulator is sodium hydroxide; and the sweetener is sucralose.

[0007] Preferably, the composite fish oil emulsion for preventing cardiovascular diseases comprises the following components in parts by weight: 10-15 parts of fish oil, 0.5-1.5 parts of rice bran fatty alkyl alcohol, 10-15 parts of hemoprotein peptide concentrate, 10-15 parts of red yeast rice, 10-15 parts of hawthorn, 10-15 parts of lotus leaves, 8-12 parts of enoki mushroom extract powder, 8-10 parts of sorbitol, 5-8 parts of glycerol, 1-2 parts of citric acid fatty acid esters, 1-2 parts of mono- and di-glycerides, 0.01-0.03 parts of sweet orange oil, 0.01-0.03 parts of lemon oil, 0.01-0.03 parts of vitamin E, 0.4-0.8 parts of emulsifier, 0.1-0.2 parts of pH regulator, 1.5-2.5 parts of sweetener, and 2.5-3.5 parts of antioxidant.

[0008] Preferably, the composite fish oil emulsion for preventing cardiovascular diseases specifically comprises the following components in parts by weight: 10 parts of fish oil, 0.5 parts of rice bran fatty alkyl alcohol, 10 parts of hemoprotein peptide concentrate, 10 parts of red yeast rice, 10 parts of hawthorn, 10 parts of lotus leaves, 8 parts of Flammulina velutipes extract powder, 8 parts of sorbitol, 5 parts of glycerol, 1 part of citric acid fatty acid esters, 1 part of mono- and di-glycerides, 0.01 parts of sweet orange oil, 0.01 parts of lemon oil, 0.01 parts of vitamin E, 0.4 parts of emulsifier, 0.1 parts of pH regulator, 1.5 parts of sweetener, and 2.5 parts of antioxidant.

[0009] Preferably, the composite fish oil emulsion for preventing cardiovascular diseases comprises the following components in parts by weight: 15 parts of fish oil, 1.5 parts of rice bran fatty alkyl alcohol, 15 parts of hemoprotein peptide concentrate, 15 parts of red yeast rice, 15 parts of hawthorn, 15 parts of lotus leaf, 12 parts of enoki mushroom extract powder, 10 parts of sorbitol, 8 parts of glycerol, 2 parts of citric acid fatty acid esters, 2 parts of mono- and di-glycerides, 0.03 parts of sweet orange oil, 0.03 parts of lemon oil, 0.03 parts of vitamin E, 0.8 parts of emulsifier, 0.2 parts of pH regulator, 2.5 parts of sweetener, and 3.5 parts of antioxidant.

[0010] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0011] Step 1, weigh each raw material;

[0012] Step 2: dispersing the emulsifier in deionized water, heating it and then performing magnetic stirring under the temperature condition;

[0013] Step 3: Pour the dispersed emulsion and the remaining raw materials into a homogenizer and homogenize at a speed of 8000-8500 r / min for 3-7 minutes to obtain a composite fish oil emulsion.

[0014] Preferably, in step 2, the temperature is raised to 50-60° C., the stirring speed is 600-1000 r / min, and the stirring time is 1.5-2 h.

[0015] Preferably, in step three, a dual-channel homogenizer with controllable temperature is used.

[0016] Beneficial Effects

[0017] The present invention provides a composite fish oil emulsion for preventing cardiovascular diseases and its preparation process. Compared with the prior art, it has the following beneficial effects:

[0018] (1) The composite fish oil emulsion for preventing cardiovascular diseases and its preparation process increase the bioavailability by making fish oil into an emulsion dosage form; and the emulsion is prepared by a dual-channel homogenizer with controllable temperature to reduce the fishy smell and increase the stability of the emulsion; and the appropriate temperature combined with the homogenization process can enable the emulsifier to better play its role in reducing the surface tension of the oil-water interface, forming a more stable emulsion structure, and preventing the effective ingredients in the fish oil from being exposed to environmental factors that can cause oxidation, thereby enhancing the antioxidant properties of the fish oil emulsion.

[0019] (2) The composite fish oil emulsion for preventing cardiovascular diseases and its preparation process are as follows: fish oil itself is beneficial to regulating blood lipids, red yeast rice contains lovastatin which can lower cholesterol, hawthorn and lotus leaves assist in lowering blood lipids, and work together with fish oil to enhance the regulating effect of blood lipids, reduce blood viscosity, and reduce the risk of cardiovascular diseases; fish oil provides omega-3 fatty acids, blood protein peptide concentrate provides protein, and rice bran fatty alkyl alcohol has a nutritional and health-care effect. The three synergistically increase the nutritional value of the product, help to enhance human immunity and improve body functions; at the same time, hawthorn can promote digestion, and enoki mushroom extract powder regulates intestinal function. When used together with fish oil, they can better promote nutrient absorption and reduce gastrointestinal burden.

[0020] (3) The composite fish oil emulsion for preventing cardiovascular diseases and its preparation process can prevent the product from drying up and maintaining its shape through glycerol and sorbitol; monoglycerides and diglycerides, citric acid fatty acid esters, soybean lecithin and sucrose fatty acid esters can make the fish oil and other ingredients evenly mixed, prevent oil phase separation, and ensure that the product has a uniform and stable texture; sweet orange oil and lemon oil improve the odor, sorbitol and glycerol improve the taste, and sucralose increases the sweetness, making the product more sensory acceptable and covering up the fishy smell of the fish oil itself; vitamin E and antioxidants can prevent the fish oil and other nutrients from being oxidized, and sodium hydroxide can adjust the pH value to create an environment that is not conducive to oxidation reactions, thereby jointly extending the shelf life of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a comparative diagram of antioxidant tests provided for a composite fish oil emulsion for preventing cardiovascular diseases and its preparation process of the present invention. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] Example 1

[0024] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0025] Step 1, weigh the following raw materials: 10g fish oil, 0.5g rice bran fatty alkyl alcohol, 10g hemoprotein peptide concentrate, 10g red yeast rice, 10g hawthorn, 10g lotus leaf, 8g enoki mushroom extract powder, 8g sorbitol, 5g glycerol, 1g citric acid fatty acid ester, 1g mono- and di-glycerides, 0.01g sweet orange oil, 0.01g lemon oil, 0.01g vitamin E, 0.4g soybean lecithin and sucrose fatty acid ester, 0.1g sodium hydroxide, 1.5g sucralose, and 2.5g antioxidant;

[0026] Step 2: Disperse soybean lecithin and sucrose fatty acid ester in deionized water, heat to 50°C, and stir magnetically at 600 r / min for 1.5 h under this temperature condition;

[0027] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8000 r / min for 3 minutes to obtain a composite fish oil emulsion.

[0028] Example 2

[0029] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0030] Step 1, weigh the following raw materials: 12g fish oil, 1g rice bran fatty alkyl alcohol, 13g hemoprotein peptide concentrate, 14g red yeast rice, 11g hawthorn, 12g lotus leaf, 10g enoki mushroom extract powder, 9g sorbitol, 7g glycerol, 1.5g citric acid fatty acid ester, 1.5g mono- and di-glycerides, 0.02g sweet orange oil, 0.02g lemon oil, 0.02g vitamin E, 0.6g polyglycerol fatty acid ester and egg yolk lecithin, 0.1g sodium hydroxide, 2g sucralose, and 3g antioxidant;

[0031] Step 2: Disperse polyglycerol fatty acid ester and egg yolk lecithin in deionized water, heat to 55° C., and stir magnetically at 800 r / min for 1.8 h under this temperature condition;

[0032] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8300 r / min for 5 minutes to obtain a composite fish oil emulsion.

[0033] Example 3

[0034] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0035] Step 1, weigh the following raw materials: 15g fish oil, 1.5g rice bran fatty alkyl alcohol, 15g hemoprotein peptide concentrate, 15g red yeast rice, 15g hawthorn, 15g lotus leaf, 12g enoki mushroom extract powder, 10g sorbitol, 8g glycerol, 2g citric acid fatty acid ester, 2g mono- and di-glycerides, 0.03g sweet orange oil, 0.03g lemon oil, 0.03g vitamin E, 0.8g sucrose fatty acid ester and polyglycerol fatty acid ester, 0.2g pH adjuster, 2.5g sweetener, 3.5g antioxidant;

[0036] Step 2: Disperse sucrose fatty acid ester and polyglycerol fatty acid ester in deionized water, heat to 60° C., and stir magnetically at 1000 r / min for 2 h under the same temperature condition;

[0037] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8500 r / min for 7 minutes to obtain a composite fish oil emulsion.

[0038] Comparative Example 1

[0039] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0040] Step 1, weigh the following raw materials: 10g fish oil, 10g hemoprotein peptide concentrate, 10g red yeast rice, 10g hawthorn, 10g lotus leaf, 8g enoki mushroom extract powder, 8g sorbitol, 5g glycerol, 1g citric acid fatty acid ester, 1g mono- and di-glycerides, 0.01g sweet orange oil, 0.01g lemon oil, 0.01g vitamin E, 0.4g soybean lecithin and sucrose fatty acid ester, 0.1g sodium hydroxide, 1.5g sucralose, and 2.5g antioxidant;

[0041] Step 2: Disperse soybean lecithin and sucrose fatty acid ester in deionized water, heat to 50°C, and stir magnetically at 600 r / min for 1.5 h under this temperature condition;

[0042] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8000 r / min for 3 minutes to obtain a composite fish oil emulsion.

[0043] Comparative Example 2

[0044] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0045] Step 1, weigh the following raw materials: 10g fish oil, 0.5g rice bran fatty alkyl alcohol, 10g hemoprotein peptide concentrate, 8g Flammulina velutipes extract powder, 8g sorbitol, 5g glycerol, 1g citric acid fatty acid ester, 1g mono- and di-glycerides, 0.01g sweet orange oil, 0.01g lemon oil, 0.01g vitamin E, 0.4g soybean lecithin and sucrose fatty acid ester, 0.1g sodium hydroxide, 1.5g sucralose, and 2.5g antioxidant;

[0046] Step 2: Disperse soybean lecithin and sucrose fatty acid ester in deionized water, heat to 50°C, and stir magnetically at 600 r / min for 1.5 h under this temperature condition;

[0047] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8000 r / min for 3 minutes to obtain a composite fish oil emulsion.

[0048] Comparative Example 3

[0049] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0050] Step 1, weigh the following raw materials: 10g fish oil, 0.5g rice bran fatty alkyl alcohol, 10g red yeast rice, 10g hawthorn, 10g lotus leaf, 8g enoki mushroom extract powder, 8g sorbitol, 5g glycerol, 1g citric acid fatty acid ester, 1g mono- and di-glycerides, 0.01g sweet orange oil, 0.01g lemon oil, 0.01g vitamin E, 0.4g soybean lecithin and sucrose fatty acid ester, 0.1g sodium hydroxide, 1.5g sucralose, and 2.5g antioxidant;

[0051] Step 2: Disperse soybean lecithin and sucrose fatty acid ester in deionized water, heat to 50°C, and stir magnetically at 600 r / min for 1.5 h under this temperature condition;

[0052] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8000 r / min for 3 minutes to obtain a composite fish oil emulsion.

[0053] Comparative Example 4

[0054] A preparation process of a composite fish oil emulsion for preventing cardiovascular diseases, specifically comprising the following preparation steps:

[0055] Step 1, weigh the following raw materials: 10g fish oil, 0.5g rice bran fatty alkyl alcohol, 10g hemoprotein peptide concentrate, 10g red yeast rice, 10g hawthorn, 10g lotus leaf, 8g enoki mushroom extract powder, 8g sorbitol, 5g glycerol, 1g citric acid fatty acid ester, 1g mono- and di-glycerides, 0.01g sweet orange oil, 0.01g lemon oil, 0.01g vitamin E, 0.4g soybean lecithin and sucrose fatty acid ester, 0.1g sodium hydroxide, and 1.5g sucralose;

[0056] Step 2: Disperse soybean lecithin and sucrose fatty acid ester in deionized water, heat to 50°C, and stir magnetically at 600 r / min for 1.5 h under this temperature condition;

[0057] Step 3: Pour the dispersed emulsion and the remaining raw materials into a temperature-controllable dual-channel homogenizer, and homogenize at a speed of 8000 r / min for 3 minutes to obtain a composite fish oil emulsion.

[0058] Antioxidant test: 50 g of the composite fish oil emulsion was placed into a 60 mL brown narrow-mouthed reagent bottle, sealed and stored in a 60°C oven, and samples were taken regularly to determine the peroxide value.

[0059] Experimental method: Healthy Wistar clean rats, each weighing about 180g, were selected. The rat thoracic aorta was isolated, the outer membrane was carefully peeled off, the inner membrane was scraped off, and the rat aortic vascular smooth muscle cells (VSMC) were cultured by the patch method. The cells were identified by immunohistochemical staining of anti-a-actin. After stasis in serum-free culture medium, 20% fetal bovine serum (FBS) was used to stimulate the proliferation of VSMC.

[0060] Table 1

[0061]

[0062]

[0063] As shown in Table 1, compared with Comparative Examples 1-4, Examples 1-3 can significantly inhibit VSMC proliferation under the culture conditions of high concentration of fetal bovine serum.

[0064] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0065] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0066] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A composite fish oil emulsion for preventing cardiovascular diseases, characterized in that: The invention comprises the following raw materials: fish oil, rice bran fatty alkyl alcohol, hemoprotein peptide concentrate, red yeast rice, hawthorn, lotus leaf, enoki mushroom extract powder, sorbitol, glycerin, citric acid fatty acid ester, monoglyceride and diglyceride, sweet orange oil, lemon oil and vitamins.

2. The composite fish oil emulsion for preventing cardiovascular diseases according to claim 1, characterized in that: The composite fish oil emulsion for preventing cardiovascular diseases also includes the following auxiliary materials: an antioxidant, an emulsifier, a pH regulator and a sweetener.

3. The composite fish oil emulsion for preventing cardiovascular diseases according to claim 2, characterized in that: The antioxidant is a composition of tea polyphenols, soybean lecithin and ascorbic acid; the emulsifier is selected from one or more of soybean lecithin, sucrose fatty acid ester, polyglycerol fatty acid ester and egg yolk lecithin; the pH regulator is sodium hydroxide; and the sweetener is sucralose.

4. The composite fish oil emulsion for preventing cardiovascular diseases according to claim 3, characterized in that: The composite fish oil emulsion for preventing cardiovascular diseases comprises the following components in parts by weight: 10-15 parts of fish oil, 0.5-1.5 parts of rice bran fatty alkyl alcohol, 10-15 parts of hemoprotein peptide concentrate, 10-15 parts of red yeast rice, 10-15 parts of hawthorn, 10-15 parts of lotus leaf, 8-12 parts of enoki mushroom extract powder, 8-10 parts of sorbitol, 5-8 parts of glycerol, 1-2 parts of citric acid fatty acid ester, 1-2 parts of mono- and di-glycerides, 0.01-0.03 parts of sweet orange oil, 0.01-0.03 parts of lemon oil, 0.01-0.03 parts of vitamin E, 0.4-0.8 parts of emulsifier, 0.1-0.2 parts of pH regulator, 1.5-2.5 parts of sweetener and 2.5-3.5 parts of antioxidant.

5. The composite fish oil emulsion for preventing cardiovascular diseases according to claim 4, characterized in that: The composite fish oil emulsion for preventing cardiovascular diseases specifically comprises the following components in parts by weight: 10 parts of fish oil, 0.5 parts of rice bran fatty alkyl alcohol, 10 parts of hemoprotein peptide concentrate, 10 parts of red yeast rice, 10 parts of hawthorn, 10 parts of lotus leaves, 8 parts of enoki mushroom extract powder, 8 parts of sorbitol, 5 parts of glycerol, 1 part of citric acid fatty acid ester, 1 part of mono- and di-glycerides, 0.01 parts of sweet orange oil, 0.01 parts of lemon oil, 0.01 parts of vitamin E, 0.4 parts of emulsifier, 0.1 parts of pH regulator, 1.5 parts of sweetener and 2.5 parts of antioxidant.

6. The composite fish oil emulsion for preventing cardiovascular diseases according to claim 4, characterized in that: The composite fish oil emulsion for preventing cardiovascular diseases comprises the following components in parts by weight: 15 parts of fish oil, 1.5 parts of rice bran fatty alkyl alcohol, 15 parts of hemoprotein peptide concentrate, 15 parts of red yeast rice, 15 parts of hawthorn, 15 parts of lotus leaf, 12 parts of enoki mushroom extract powder, 10 parts of sorbitol, 8 parts of glycerol, 2 parts of citric acid fatty acid esters, 2 parts of mono- and di-glycerides, 0.03 parts of sweet orange oil, 0.03 parts of lemon oil, 0.03 parts of vitamin E, 0.8 parts of emulsifier, 0.2 parts of pH regulator, 2.5 parts of sweetener and 3.5 parts of antioxidant.

7. A preparation process of the composite fish oil emulsion for preventing cardiovascular diseases according to claim 3, characterized in that: The specific preparation steps include the following: Step 1, weigh each raw material; Step 2: dispersing the emulsifier in deionized water, heating it and then performing magnetic stirring under the temperature condition; Step 3: Pour the dispersed emulsion and the remaining raw materials into a homogenizer and homogenize at a speed of 8000-8500 r / min for 3-7 minutes to obtain a composite fish oil emulsion.

8. The preparation process of the composite fish oil emulsion for preventing cardiovascular diseases according to claim 7, characterized in that: In the step 2, the temperature is raised to 50-60° C., the stirring speed is 600-1000 r / min, and the stirring time is 1.5-2 h.

9. The preparation process of the composite fish oil emulsion for preventing cardiovascular diseases according to claim 7, characterized in that: In the step three, a dual-channel homogenizer with controllable temperature is used.

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