Catheter pump with oxygenation function

Abstract

According to the catheter pump with the oxygenation function, the myocardial anoxia condition can be directly improved, the near end of a motor is connected with a catheter, the far end of the motor is coaxially connected with an impeller, the periphery of the impeller is covered with a blood outflow cage, the far end of the blood outflow cage is fixed to the near end of a blood inflow cage through a sleeve, and the far end of the blood inflow cage is further connected with a pigtail pipe; an oxygenation unit is arranged on the blood inflow cage, and the oxygenation unit is used for generating oxygen in the left ventricle on time and on demand according to the physiological signals collected by the sensing unit and releasing the oxygen into the blood of the left ventricle. The oxygenation unit enters the left ventricle along with the blood inflow cage, oxygen is directly produced in situ in the left ventricle, oxygen is supplied to blood of the left ventricle, the myocardial anoxia condition is rapidly improved, and heart recovery is promoted. The oxygenation unit is integrated on the catheter pump and intervenes through a blood vessel together with the catheter pump, operation is easy, and damage to the blood vessel can be reduced. By means of the oxygen supply mode, the myocardial anoxia condition can be directly improved, and the aortic valve regurgitation condition and the systemic circulation oxygen supply condition can also be improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a catheter pump with an oxygenation function. Background Art

[0002] The catheter pump can be introduced into the heart percutaneously and can be constructed to assist or replace the natural heart pump function by circulating or continuously pumping blood, providing hemodynamic support for cardiogenic shock and acute heart failure. The catheter pump generally includes a motor, the proximal end of the motor is connected to the catheter, and the distal end is connected to the impeller. The motor drives the impeller to rotate and then suck the blood in the ventricle from the blood inflow cage into the cannula, and the blood outflow cage at the proximal end of the cannula flows out into the artery, establishing a left ventricle-ascending aorta drainage pathway.

[0003] Some patients with severe coronary atherosclerotic heart disease and multiple coronary artery lesions will suffer from severe myocardial hypoxia and ischemia. In the existing technology, the catheter pump directly pumps the blood in the ventricle to the ascending aorta. Although it can assist the heart to pump blood, it cannot directly and quickly improve the myocardial hypoxia state. How to achieve this function is a major problem that needs to be solved in the industry. Summary of the invention

[0004] The purpose of the present invention is to provide a catheter pump with oxygenation function which can directly improve myocardial hypoxia.

[0005] In order to achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a catheter pump with oxygenation function, including a motor, the proximal end of the motor is connected to the catheter, and the distal end is coaxially connected to an impeller, the outer peripheral cover of the impeller is provided with a blood outflow cage, the distal end of the blood outflow cage is fixed to the proximal end of the blood inflow cage through a sleeve, and the distal end of the blood inflow cage is also connected to a pigtail tube, and the blood inflow cage is provided with an oxygenation unit. The oxygenation unit produces oxygen on time and on demand in the left ventricle according to the physiological signals collected by the sensing unit and releases oxygen into the blood in the left ventricle.

[0006] Furthermore, the oxygenation unit includes a microfluidic chip and an enzyme membrane. The hydrogen peroxide solution enters the microchannel from the liquid guide tube and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules contact the enzyme membrane and undergo a chemical reaction to generate and , and Escapes and enters the blood in the ascending aorta.

[0007] Furthermore, the oxygenation unit includes a microfluidic chip, a first liquid inlet pipe for delivering hydrogen peroxide and a second liquid inlet pipe for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip, and the hydrogen peroxide solution undergoes a chemical reaction in the mixing channel of the microfluidic chip to generate and , and It escapes from the substrate outlet of the microfluidic chip and enters the blood in the ascending aorta.

[0008] Furthermore, the blood inflow cage includes a circular tubular main body, a blood inlet is opened on the peripheral wall of the main body, the microfluidic chip is wrapped on the tube body of the circular tube proximal to the blood inlet, and the microfluidic chip is an arc-shaped structure that fits the shape of the outer wall of the circular tube, the wall thickness of the circular tube segment corresponding to the microfluidic chip is less than the wall thickness of the tube segments on both sides, the outer wall of the microfluidic chip is smoothly connected with the outer walls of the tube segments on both sides, the liquid guide tube is connected to the liquid inlet of the microfluidic chip, the substrate outlet of the microfluidic chip is connected to a micro reaction chamber, and the enzyme membrane is arranged in the micro reaction chamber.

[0009] Furthermore, the blood inflow cage includes a circular tubular main body, a blood inlet is opened on the peripheral wall of the main body, a water drop head is connected to the distal end of the main body, the distal end of the water drop head is a conical column section, the microfluidic chip is wrapped on the outer wall of the conical column section, and the microfluidic chip is an arc structure that fits the shape of the outer wall of the conical column section, the wall thickness of the circular tube section corresponding to the microfluidic chip is less than the wall thickness of the tube sections on both sides, the outer wall of the microfluidic chip is smoothly connected with the outer walls of the tube sections on both sides, the liquid guide tube is connected to the liquid inlet of the microfluidic chip, the substrate outlet of the microfluidic chip is connected to a micro reaction chamber, and the enzyme membrane is arranged in the micro reaction chamber.

[0010] Furthermore, the micro-reaction chamber is tubular as a whole, one end of the tube body is connected to the substrate outlet of the microfluidic chip, and the other end is provided with an outlet, the enzyme membrane is arranged in the tube cavity near the outlet, and the enzyme membrane separates the tube cavity, and the catalase is fixed on the membrane sheet near the outlet side.

[0011] Furthermore, the enzyme membrane is placed on a plastic sheet, and the electrode passes through and adheres to the plastic sheet. The enzyme membrane and the electrode constitute an enzymatic current sensor. The enzymatic current sensor collects current signals and feeds them back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid in the microfluidic chip in real time.

[0012] Furthermore, the sleeve includes a spring tube and an inner membrane and an outer membrane covering the inner and outer sides of the spring tube. The spring tube is formed by winding a shape memory wire. A channel is sandwiched between the spring tube and the outer membrane, and the liquid guide tube passes through the channel.

[0013] Furthermore, a plane is arranged on the outer wall of the blood inflow cage along its axial direction, the micro-reaction chamber is fixed on the plane, the outer cover of the micro-reaction chamber is provided with a protective cover, the outer wall of the protective cover is constructed as an arc-shaped guide surface extending from the distal end to the proximal end, and the two ends of the protective cover are also fixed on the plane.

[0014] Furthermore, a groove is provided on the motor housing, and the liquid guide tube passes through the groove and enters the catheter from the tail of the motor. The groove is filled with epoxy resin glue, and the catheter is also provided with a flushing tube, an electric cable, a reinforced steel cable and an optical fiber.

[0015] In the above scheme, the oxygenation unit is arranged on the blood inflow cage, that is, the oxygenation unit enters the left ventricle along with the blood inflow cage, and directly produces oxygen in situ in the left ventricle to supply oxygen to the blood in the left ventricle, thereby quickly improving myocardial hypoxia and promoting cardiac recovery. The oxygenation unit is integrated on the catheter pump and is inserted into the blood vessels together with the catheter pump. The operation is simple and can reduce damage to blood vessels. At the same time, the oxygenation unit produces oxygen in situ and on demand in the left ventricle, that is, we produce oxygen in situ in the left ventricle according to the amount of oxygen needed in the blood. This oxygen supply method can directly improve myocardial hypoxia, and can also improve aortic valve regurgitation and systemic oxygen supply. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of the overall structure of the catheter pump in Example 1; Figure 2 for Figure 1 Schematic diagram of the structure after removing the catheter and pigtail tube; Figure 3 This is a schematic diagram of the structure of the blood inflow cage and the oxygenation unit in Example 1; Figure 4 This is a schematic diagram of the structure of the blood inflow cage in Example 1; Figure 5 This is a planar expansion schematic diagram of the oxygenation unit in Example 1; Figure 6 for Figure 5 The middle part is an enlarged schematic diagram; Figure 7 Schematic diagram of the structure of the microfluidic chip; Figure 8 is a schematic diagram of the overall structure of the catheter pump in Example 2; Fig. 9 for Figure 8 Schematic diagram of the structure after removing the catheter and pigtail tube; Fig.10 This is a schematic diagram of the structure of the blood inflow cage and the oxygenation unit in Example 2; Fig.11 This is a schematic diagram of the structure of the blood inflow cage in Example 2; Fig.12 This is a planar expansion schematic diagram of the oxygenation unit in Example 2; Fig.13 is a cross-sectional view of the casing; Fig.14 for Fig.13 Middle AA section view; Fig.15 for Figure 1 Middle BB section view; Fig.16 Schematic diagram of the planar development of the microfluidic chip in Example 3; Fig.17 This is a schematic diagram of the catheter pump in use. DETAILED DESCRIPTION

[0017] To facilitate understanding, let us first define the direction: "proximal" and "proximal side" refer to the side close to the operator / doctor, and "distal" and "distal side" refer to the side away from the operator / doctor, that is, the side close to the heart. Figure 1-Figure 17 The invention is further described in detail.

[0018] A catheter pump with oxygenation function comprises a motor 10, wherein the proximal end of the motor 10 is connected to a catheter 20, and the distal end is coaxially connected to an impeller, a blood outflow cage 30 is provided on the outer peripheral cover of the impeller, the distal end of the blood outflow cage 30 is fixed to the proximal end of a blood inflow cage 50 through a sleeve 40, and a pigtail tube 60 is also connected to the distal end of the blood inflow cage 50, and an oxygenation unit 70 is provided on the blood inflow cage 50, and the oxygenation unit 70 produces oxygen in the left ventricle on time and on demand according to the physiological signal collected by the sensor unit and releases the oxygen into the blood in the ascending left ventricle.

[0019] In the above scheme, the catheter pump is inserted into the ventricle through the blood vessels. At this time, the pigtail tube 60, the blood inflow cage 50 and part of the sleeve 40 are located in the left ventricle, the sleeve 40 crosses the aortic valve, and part of the sleeve, the blood outflow cage 30 and the motor 10 are located in the ascending aorta. The motor 10 drives the impeller to rotate and pumps the blood in the left ventricle into the aorta, and then participates in the systemic circulation. The oxygenation unit 70 is arranged on the blood inflow cage 50, that is, the oxygenation unit enters the left ventricle with the blood inflow cage 50, directly produces oxygen in situ in the left ventricle, and supplies oxygen to the blood in the left ventricle, thereby quickly improving the myocardial hypoxia and promoting heart recovery. The oxygenation unit 70 is integrated on the catheter pump, and is inserted through the blood vessels together with the catheter pump. The operation is simple and can reduce the damage to the blood vessels. At the same time, the oxygenation unit 70 produces oxygen in the left ventricle on time and on demand, that is, how much oxygen is needed in the blood and when oxygen is needed, we produce how much oxygen in the left ventricle, when oxygen is needed, and in situ.

[0020] Another key point of the present invention is to directly supplement oxygen into the left ventricle. This arrangement also has the following beneficial effects: 1. Directly improve myocardial hypoxia: When oxygen is directly supplemented into the left ventricle, it can be absorbed by the myocardium more quickly, improving myocardial hypoxia and promoting the recovery of myocardial function.

[0021] 2. Improve aortic regurgitation: Supplementing oxygen into the ventricles will change the blood composition and pressure distribution in the ventricular cavity, thereby improving aortic regurgitation; at the same time, by precisely controlling the amount of oxygen generated, it will not affect the hemodynamics inside the heart.

[0022] 3. Improve the oxygen supply to the systemic circulation: The blood replenished into the ventricles enters the ascending aorta through the heart / catheter pump and then reaches the systemic circulation, thus improving the oxygen supply to the systemic circulation to a certain extent.

[0023] In order to achieve on-demand oxygen production, it is hoped that hydrogen peroxide and catalase can react in small amounts at a time to produce small amounts of In order to achieve the above purpose, the oxygenation unit 70 includes a microfluidic chip 71 and an enzyme membrane 72. The hydrogen peroxide solution enters the microchannel from the liquid guide tube 73 and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules contact the enzyme membrane 72 and undergo a chemical reaction to generate and , and Escapes and enters the blood in the left ventricle. Here, hydrogen peroxide and catalase react to produce oxygen. The product of the reaction is and ,in Mixed into the blood in the left ventricle, oxygenating the blood. It is also needed by the human body, so it will not cause any harm to the human body.

[0024] Membranes are good carriers for enzyme immobilization. Compared with common chemical reactions, the rate of hydrogen peroxide enzymatic reaction is fast and In the catalytic process, the higher the concentration of catalase, The faster the catalysis occurs, the higher the concentration of catalase. Therefore, we fix the catalase on the membrane to ensure the high concentration of catalase. The microfluidic chip 71 is made of a flexible material such as polydimethylsiloxane---PDMS, and is provided with a microchannel. The size of the microchannel is in the micrometer or even nanometer level, which can accurately control the reaction amount. The technology of the microfluidic chip 71 that can separate the hydrogen peroxide solution into microdroplets is a well-known technology and will not be described in detail here. After the hydrogen peroxide solution passes through the microchannel, it is separated into microdroplets arranged in a spaced manner, or even separated hydrogen peroxide molecules. Then, when the hydrogen peroxide molecules pass through the enzyme membrane 72, they react quickly with the enzyme to obtain Supply oxygen to the blood.

[0025] In order to achieve the above purpose, we use a microfluidic chip 71 to control the amount of hydrogen peroxide. The microfluidic chip 71 can achieve precise control of the fluid through microchannels and other functional components. Due to the setting of the microchannel, the micro-transport of the fluid is achieved, thereby achieving the purpose of in-situ oxygen production; the concentration of catalase on the enzyme membrane 72 is high, and a chemical reaction will occur the moment the hydrogen peroxide molecules come into contact with the enzyme membrane 72, thereby achieving the purpose of timely oxygen supply; through computer programming control, the transmission, mixing and separation of microdroplets in the channel can be accurately achieved, thereby achieving quantitative oxygen production.

[0026] Regarding the specific position of the oxygenation unit 70 on the blood inflow cage 50, the present invention provides two specific solutions. Example 1

[0027] See also Figure 1-Figure 7 As shown, the blood inflow cage 50 includes a circular tubular main body 51, a blood inlet 52 is provided on the peripheral wall of the main body 51, the microfluidic chip 71 is wrapped on the tube body of the circular tube near the blood inlet 12, and the microfluidic chip 71 is an arc-shaped structure that fits the outer wall of the circular tube, the wall thickness of the circular tube segment corresponding to the microfluidic chip 71 is less than the wall thickness of the tube segments on both sides, the outer wall of the microfluidic chip 71 is smoothly connected with the outer walls of the tube segments on both sides, the liquid guide tube 73 is connected with the liquid inlet of the microfluidic chip 71, the substrate outlet of the microfluidic chip 71 is connected with a micro reaction chamber 74, and the enzyme membrane 72 is arranged in the micro reaction chamber 74. The microfluidic chip 71 is made of a substrate with soft characteristics, such as PMDS, to adapt to the circular tube shape on the surface of the main body 51, which reduces the outer diameter of the catheter pump on the one hand, and enhances the contact area between the microfluidic chip 71 and the surface of the main body 51 on the other hand, and improves the reliability of the connection, and the two can be fixed by gluing. The wall thickness of the circular tube segment corresponding to the microfluidic chip 71 is smaller than the wall thickness of the tube segments on both sides. That is to say, there is an annular groove on the tube wall for installing the microfluidic chip 71. The outer wall of the microfluidic chip 71 is smoothly connected with the outer walls of the tube segments on both sides. From the outside, the outer diameters are similar or equal, thereby reducing the damage to the blood vessels caused by the catheter pump during intervention and withdrawal.

[0028] In this embodiment, the microfluidic chip 71 is wrapped on the outer wall of the circular tube, so its shape is regular, easy to manufacture, and the routing of the liquid guide tube 73 is relatively simple. However, the circular tube segment needs to have both the blood inlet 52 and the microfluidic chip 71, so the axial length of the circular tube segment needs to be lengthened. Example 2

[0029] See also Figure 8-Figure 12As shown, the blood inflow cage 50 includes a circular tubular main body 51, a blood inlet 52 is opened on the peripheral wall of the main body 51, a water drop head 53 is connected to the distal end of the main body 51, and the distal end of the water drop head 53 is a conical column section 54. The microfluidic chip 71 is wrapped on the outer wall of the conical column section 54, and the microfluidic chip 71 is an arc structure that fits the shape of the outer wall of the conical column section 54. The wall thickness of the circular tube section corresponding to the microfluidic chip 71 is less than the wall thickness of the tube sections on both sides. The outer wall of the microfluidic chip 71 is smoothly connected with the outer walls of the tube sections on both sides. The liquid guide tube 73 is connected to the liquid inlet of the microfluidic chip 71, and the substrate outlet of the microfluidic chip 71 is connected to a micro reaction chamber 74, and the enzyme membrane 72 is arranged in the micro reaction chamber 74.

[0030] In this embodiment, the microfluidic chip 71 is arranged on the conical column section 54, so the shape of the microfluidic chip 71 also needs to be curled into a conical column (not a complete conical column, with an opening), the manufacturing process is slightly more complicated than that of the embodiment 1, and the liquid guide tube 73 also needs to extend a distance from the outer wall of the blood inflow cage 50 to the proximal end. Since the outer diameter of the conical column section 54 itself is smaller than the outer diameter of the entire catheter pump, it is even unnecessary to do any treatment (reduce the wall thickness) to the wall thickness of the circular tube section, so the microfluidic chip 71 wrapped on the conical column section 54 will not increase the outer diameter of the entire catheter pump, and the damage to the blood vessels and heart tissues during the intervention process is small. Even if the wall thickness of the circular tube section corresponding to the microfluidic chip 71 is set to be smaller than the wall thickness of the tube sections on both sides, since the thickness of the conical column section 54 is thicker, the wall thickness treatment will not have any effect on the strength of the conical column section 54.

[0031] Further, such as Figure 6 As shown, the micro-reaction chamber 74 is tubular as a whole, i.e., a micro-channel reaction chamber, which is small in size. One end of the tube body is connected to the substrate outlet of the microfluidic chip 71, and the other end is provided with an outlet 741. The enzyme membrane 72 is provided in the tube cavity near the outlet, and the enzyme membrane 72 separates the tube cavity. The catalase is fixed on the membrane sheet on the side near the outlet 741. That is to say, when hydrogen peroxide passes through the membrane sheet and reaches the other side, it can react chemically with the enzyme, and the generated and It no longer needs to pass through the diaphragm again, so it can enter the blood more quickly and combine with the oxygen-deficient hemoglobin in the left ventricle at that moment, so as to achieve the purpose of timely and on-demand oxygen supply. A one-way valve / diaphragm structure can also be set at the outlet 741 to only allow and Alternatively, the enzyme membrane 72 allows hydrogen peroxide to pass easily, and blood, and Impassable material.

[0032] The enzyme membrane 72 is placed on a plastic sheet (shown in the figure), and the electrode (shown in the figure) passes through and adheres to the plastic sheet. The enzyme membrane 72 and the electrode constitute an enzymatic current sensor. The enzymatic current sensor collects current signals and feeds them back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid in the microfluidic chip 71 in real time. At the same time, the enzymatic current sensor can also detect the generation of chemical reactions. Concentration, real-time response The outflowing hydrogen peroxide undergoes a dismutation reaction with the catalase attached to the membrane:

[0033] In this way, the two The molecules encounter CAT successively and collide with the active center, and a disproportionation reaction occurs to generate two molecules and a molecular.

[0034] Since the microfluidic chip 71 is arranged on the blood inflow cage 50, and the liquid guide tube 73 needs to be led out to the proximal end and connected to the liquid storage tank, how to lead out the liquid guide tube 73 is a problem that needs to be considered. The sleeve 40 includes a spring tube 41 and an inner membrane 42 and an outer membrane 43 covering the inner and outer sides of the spring tube 41. The spring tube 43 is wound with a shape memory wire (such as a nickel-titanium alloy wire). A channel 44 is sandwiched between the spring tube 41 and the outer membrane 43, and the liquid guide tube 73 passes through the channel 44. In this way, the liquid guide tube 73 passes through the inner wall of the sleeve 40, on the one hand, to ensure the smoothness of the inner and outer walls of the sleeve 40, and on the other hand, the position of the liquid guide tube 73 is relatively fixed to prevent it from twisting and hindering the delivery of the hydrogen peroxide solution, and the liquid guide tube 73 is protected in the channel 44 to prevent the blood flow from affecting the delivery of the hydrogen peroxide solution, thereby ensuring the quantitative and stable delivery of the hydrogen peroxide solution.

[0035] During the process of catheter pump intervention through blood vessels, the tortuous path and / or calcified anatomical structure may hinder and damage the micro-reaction chamber 74, so a plane (not shown in the figure) is provided on the outer wall of the blood inflow cage 50 along its axial direction, and the micro-reaction chamber 74 is fixed on this plane to enhance the reliability of the connection. At the same time, the outer cover of the micro-reaction chamber 74 is provided with a protective cover 75, and the outer wall of the protective cover 75 is constructed as an arc-shaped guide surface extending from the distal end to the proximal end. The two ends of the protective cover 75 are also fixed on this plane, and the connection is firm and reliable. On the one hand, the protective cover 75 can prevent blood from directly flushing the micro-reaction chamber 74, and on the other hand, it can reduce the damage to blood vessels and other tissues during the intervention process. Example 3

[0036] like Fig.16As shown, the oxygenation unit 70 includes a microfluidic chip 71, a first liquid inlet pipe for delivering hydrogen peroxide and a second liquid inlet pipe for delivering catalase are respectively connected to the first sample port and the second sample port of the microfluidic chip 71, and the hydrogen peroxide solution undergoes a chemical reaction in the mixing channel of the microfluidic chip 71 to generate and , and Escape from the substrate outlet of the microfluidic chip 71 and enter the blood in the left ventricle. In this embodiment, two liquid inlet pipes are set to transport hydrogen peroxide and catalase respectively, so there is no need to set up structures such as enzyme membranes, and even the micro reaction chamber 74 can be set on the microfluidic chip 71 without additional settings. We use the microfluidic chip 71 to control the amount of hydrogen peroxide and catalase. The microfluidic chip 71 can accurately control the fluid through microchannels, reaction chambers and other functional components, and can accurately realize the transmission, mixing and separation of micro droplets in the channel, thereby realizing quantitative oxygen production. Compared with Example 1 and Example 2, the present embodiment can omit the enzyme membrane unit and the additional micro reaction chamber structure, so that the volume is reduced. But correspondingly, the design inside the microfluidic chip is also relatively complicated, and two liquid inlet pipes are required, and the lead-out design of the liquid inlet pipe is also more complicated.

[0037] A groove is provided on the housing of the motor 10 of the liquid guide tube 73. The liquid guide tube 73 passes through the groove and enters the catheter 20 from the tail of the motor 10. The groove is filled with epoxy resin glue. The liquid guide tube 73 is placed in the groove and fixed with epoxy resin glue and the groove is filled, so as to ensure the flatness and smoothness of the surface of the motor 10 housing, and further reduce the damage to blood vessels or other tissues during the intervention process. The catheter 20 is also provided with a flushing tube 21, a cable 22, a reinforced steel cable 23 and an optical fiber 24, wherein the optical fiber 24 is used to transmit optical signals, the liquid guide tube 73 is used to transport hydrogen peroxide solution, the flushing tube 21 is used to transport backwashing liquid to prevent blood from entering the motor 10 to form a thrombus, the cable 22 is used to power the motor 10, and the reinforced steel cable 23 is used to enhance the rigidity of the catheter 20 so that it can push the pumping assembly into the designated position.

[0038] The above structure can also be applied to a right ventricular catheter pump, a foldable blood pump and an IABP device to supplement oxygen into the human body.

[0039] Of course, it is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, but also includes the same or similar structures that can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-limiting, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention. Any reference numerals in the claims should not be regarded as limiting the claims involved.

[0040] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A catheter pump with oxygenation function, comprising a motor (10), wherein the proximal end of the motor (10) is connected to a catheter (20), and the distal end is coaxially connected to an impeller, a blood outflow cage (30) is provided on the outer periphery of the impeller, the distal end of the blood outflow cage (30) is fixed to the proximal end of a blood inflow cage (50) through a sleeve (40), and the distal end of the blood inflow cage (50) is also connected to a pigtail tube (60), characterized in that: The blood inflow cage (50) is provided with an oxygenation unit (70), which produces oxygen in the left ventricle on time and as needed according to the physiological signals collected by the sensor unit, and releases oxygen into the blood in the left ventricle.

2. A catheter pump with oxygenation function according to claim 1, characterized in that: The oxygenation unit (70) comprises a microfluidic chip (71) and an enzyme membrane (72). The hydrogen peroxide solution enters the microfluidic channel from the liquid guide tube (73) and is separated into independent hydrogen peroxide molecules. The hydrogen peroxide molecules contact the enzyme membrane (72) and undergo a chemical reaction to generate and , and Escapes and enters the blood in the ascending aorta.

3. The catheter pump with oxygen supply function according to claim 1, characterized in that: The oxygenation unit (70) comprises a microfluidic chip (71), wherein a first liquid inlet pipe for conveying hydrogen peroxide and a second liquid inlet pipe for conveying catalase are respectively connected to a first sample port and a second sample port of the microfluidic chip (71), and a hydrogen peroxide solution undergoes a chemical reaction in a mixing channel of the microfluidic chip (71) to generate and , and It escapes from the substrate outlet of the microfluidic chip (71) and enters the blood in the ascending aorta.

4. A catheter pump with oxygenation function according to claim 2, characterized in that: The blood inflow cage (50) comprises a main body (51) in the shape of a circular tube, a blood inlet (52) is provided on the peripheral wall of the main body (51), the microfluidic chip (71) is wrapped on the tube body of the circular tube proximal to the blood inlet (52), and the microfluidic chip (71) is an arc-shaped structure that fits the shape of the outer wall of the circular tube, the wall thickness of the circular tube section corresponding to the microfluidic chip (71) is smaller than the wall thickness of the tube sections on both sides, the outer wall of the microfluidic chip (71) is smoothly connected with the outer walls of the tube sections on both sides, the liquid guide tube (73) is connected to the liquid inlet of the microfluidic chip (71), the substrate outlet of the microfluidic chip (71) is connected to a micro reaction chamber (74), and the enzyme membrane (72) is arranged in the micro reaction chamber (74).

5. A catheter pump with oxygenation function according to claim 2, characterized in that: The blood inflow cage (50) comprises a main body (51) in the shape of a circular tube. A blood inlet (52) is provided on the peripheral wall of the main body (51). The distal end of the main body (51) is connected to a water drop head (53). The distal end of the water drop head (53) is a conical column section (54). The microfluidic chip (71) is wrapped on the outer wall of the conical column section (54). The microfluidic chip (71) is an arc-shaped structure that fits the shape of the outer wall of the conical column section (54). The wall thickness of the circular tube section corresponding to the microfluidic chip (71) is less than the wall thickness of the tube sections on both sides. The outer wall of the microfluidic chip (71) is smoothly connected to the outer walls of the tube sections on both sides. The liquid guide tube (73) is connected to the liquid inlet of the microfluidic chip (71). The substrate outlet of the microfluidic chip (71) is connected to a micro reaction chamber (74). The enzyme membrane (72) is arranged in the micro reaction chamber (74).

6. A catheter pump with oxygenation function according to claim 4 or 5, characterized in that: The micro-reaction chamber (74) is tubular as a whole, one end of the tube body is connected to the substrate outlet of the microfluidic chip (71), and the other end is provided with an outlet (741). The enzyme membrane (72) is arranged in the inner cavity of the tube near the outlet, and the enzyme membrane (72) divides the inner cavity of the tube. The catalase is fixed on the membrane sheet near the side of the outlet (741). The enzyme membrane (72) is placed on the plastic sheet. The electrode passes through and is bonded to the plastic sheet. The enzyme membrane (72) and the electrode constitute an enzymatic current sensor. The enzymatic current sensor collects current signals and feeds them back to the control host. The control host adjusts and controls the delivery amount of hydrogen peroxide liquid of the microfluidic chip (71) in real time.

7. A catheter pump with oxygen supply function according to claim 4 or 5, characterized in that: The sleeve (40) comprises a spring tube (41) and an inner membrane (42) and an outer membrane (43) covering the inner and outer sides of the spring tube (41); the spring tube (43) is formed by winding a shape memory wire; a channel (44) is sandwiched between the spring tube (41) and the outer membrane (43); and the liquid guide tube (73) passes through the channel (44).

8. A catheter pump with oxygen supply function according to claim 4 or 5, characterized in that: A plane is provided on the outer wall of the blood inflow cage (50) along its axial direction, and the micro-reaction chamber (74) is fixed on the plane. The outer cover of the micro-reaction chamber (74) is provided with a protective cover (75), and the outer wall of the protective cover (75) is constructed as an arc-shaped guide surface extending from the distal end to the proximal end, and both ends of the protective cover (75) are also fixed on the plane.

9. A catheter pump with oxygen supply function according to claim 4 or 5, characterized in that: A groove is provided on the housing of the motor (10), and the liquid guide tube (73) passes through the groove and enters the catheter (20) from the rear end of the motor (10). The groove is filled with epoxy resin glue. The catheter (20) is also provided with a flushing tube (21), an electric cable (22), a reinforced steel cable (23) and an optical fiber (24).

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