A gastrointestinal symptom prediction system

Abstract

The present application relates to the technical field of medical data processing, and discloses a gastrointestinal symptom prediction system, which compares the change trend of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of a to-be-tested newborn with the change trend of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of a group of newborns without gastrointestinal symptoms and a group of newborns with gastrointestinal symptoms in a corresponding gestational age range, so as to accurately predict whether the to-be-tested newborn has gastrointestinal symptoms, help to deeply understand the gastrointestinal condition of the newborn, provide reliable data guidance for the clinical nursing of the newborn, and reduce the probability of the newborn suffering from gastrointestinal diseases.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical data processing, and particularly relates to a gastrointestinal symptom prediction system. BACKGROUND

[0002] With the continuous improvement of medical technology, premature infants (PI) and very low birth weight infants (VLBW) with a body weight less than 1500g have become the most important part of the neonatal intensive care unit (NICU), and they need individualized treatment and delicate care due to small gestational age, low body weight and complex conditions. Timely nutrition and proper feeding not only can reduce the incidence of complications in the early stage of birth, especially necrotizing enterocolitis (NEC) in newborns, but also can have an important impact on long-term prognosis. The gastrointestinal organs of newborns are still relatively immature after birth. The stomach is small and the gastric acid secretion is limited, which limits their ability to digest and absorb a large amount of food. In addition, the barrier function of the gastric mucosa is not strong enough and is easily affected by external stimuli and infection. The surface area of the small intestine is relatively small, which limits the nutrient absorption capacity. Therefore, their gastrointestinal symptoms need to be monitored at all times. At present, the gastrointestinal symptoms of newborns are observed by medical staff, which is low in efficiency and poor in accuracy.

[0003] Therefore, there is an urgent need for a gastrointestinal symptom prediction system to assist in understanding the gastrointestinal symptoms of newborns, provide data guidance for the clinical care of newborns, and reduce the probability of gastrointestinal diseases in newborns. SUMMARY

[0004] The present application provides a gastrointestinal symptom prediction system to solve the defects that the current observation of the gastrointestinal symptoms of newborns by medical staff is low in efficiency and poor in accuracy.

[0005] The present application provides a gastrointestinal symptom prediction system, which comprises:

[0006] The first data receiving module is configured to receive the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages from at least one terminal, wherein the subject is a newborn;

[0007] The first data processing module is configured to obtain the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages;

[0008] The prediction module is configured to: according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, and by using a preset determination standard, obtain a prediction result of whether the subject has gastrointestinal symptoms.

[0009] The data output module is configured to: send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal.

[0010] According to the gastrointestinal symptom prediction system provided by the application, the prediction module comprises:

[0011] The trend obtaining submodule is configured to: according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, obtain the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject.

[0012] The determination submodule is configured to: according to the preset determination standard, compare the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject with the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data corresponding to the gestational age range of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms, to obtain the prediction result of whether the subject has gastrointestinal symptoms.

[0013] According to the gastrointestinal symptom prediction system provided by the application, the superior mesenteric artery ultrasound data comprises any one or any combination of the following: the highest flow rate of the superior mesenteric artery in the systolic period, the lowest flow rate of the superior mesenteric artery in the diastolic period, and the resistance index of the superior mesenteric artery.

[0014] According to the gastrointestinal symptom prediction system provided by the application, the different gestational ages comprise the first day after birth, the third day after birth, and the seventh day after birth.

[0015] According to the gastrointestinal symptom prediction system provided by the application, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data corresponding to the gestational age range of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms comprise:

[0016] The highest flow rate of the middle cerebral artery in the systolic period and the lowest flow rate of the middle cerebral artery in the diastolic period of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms increase from the first day after birth to the seventh day after birth, and the resistance index of the middle cerebral artery decreases.

[0017] According to the gastrointestinal symptom prediction system provided by the application, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data corresponding to the gestational age range of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms comprise:

[0018] The mesenteric artery resistance index of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms is less than the middle cerebral artery resistance index on the first day after birth, and the mesenteric artery resistance index of the newborn group with gastrointestinal symptoms is greater than the middle cerebral artery resistance index on the third day after birth and the seventh day after birth, and the mesenteric artery resistance index of the newborn group without gastrointestinal symptoms is less than the middle cerebral artery resistance index.

[0019] According to the gastrointestinal symptom prediction system provided by the application, the change trend of the mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms corresponding to the gestational age range, comprising:

[0020] The mesenteric artery resistance index of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms increases on the first day after birth, and the mesenteric artery resistance index of the newborn group without gastrointestinal symptoms increases on the third day after birth and the seventh day after birth, and the mesenteric artery resistance index of the newborn group with gastrointestinal symptoms decreases.

[0021] According to the gastrointestinal symptom prediction system provided by the application, the change trend of the mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms corresponding to the gestational age range, comprising:

[0022] The mesenteric artery systolic peak flow of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms increases from the first day after birth to the seventh day after birth, and the mesenteric artery diastolic minimum flow of the newborn group with gastrointestinal symptoms is greater than that of the newborn group without gastrointestinal symptoms on the third day after birth and the seventh day after birth, and the mesenteric artery resistance index of the newborn group with gastrointestinal symptoms is less than that of the newborn group without gastrointestinal symptoms.

[0023] According to the gastrointestinal symptom prediction system provided by the application, the preset determination standard comprises: when the change trend of the mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the testee are consistent with the change trend of the mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the newborn group without gastrointestinal symptoms corresponding to the gestational age range, it is determined that the testee has not appeared gastrointestinal symptoms, and when the change trend of the mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the testee are consistent with the change trend of the mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the newborn group with gastrointestinal symptoms corresponding to the gestational age range, it is determined that the testee has appeared gastrointestinal symptoms.

[0024] In one specific embodiment, the neonate can be a full-term neonate. In another embodiment, the neonate can also be a preterm infant, especially a very low birth weight infant. The present application is particularly suitable for predicting gastrointestinal symptoms in preterm infants, especially very low birth weight infants.

[0025] The gastrointestinal symptom prediction system provided by the present application further comprises:

[0026] The first cause analysis module is configured to, when the prediction result is that the subject has developed gastrointestinal symptoms, obtain the cause of the development of the gastrointestinal symptoms of the subject according to the diastolic minimum flow rate of the superior mesenteric artery of the subject.

[0027] The gastrointestinal symptom prediction system provided by the present application further comprises:

[0028] The second data receiving module is configured to receive the gastric bubble sonogram of the subject before and after feeding.

[0029] The second data processing module is configured to obtain the gastric emptying rate and the gastric emptying time of the subject according to the gastric bubble sonogram of the subject before and after feeding.

[0030] The second cause analysis module is configured to, when the prediction result is that the subject has developed gastrointestinal symptoms, obtain the cause of the development of the gastrointestinal symptoms of the subject in combination with the gastric emptying rate and the gastric emptying time of the subject.

[0031] The present application further provides an electronic device comprising a processor and a memory storing a computer program, wherein the processor implements the following steps when executing the computer program:

[0032] The processor receives the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages from at least one terminal.

[0033] The processor obtains the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages.

[0034] The processor obtains the prediction result of whether the subject has developed gastrointestinal symptoms by using a preset determination standard according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages.

[0035] The processor sends the prediction result of whether the subject has developed gastrointestinal symptoms to at least one terminal.

[0036] The present application further provides a non-transitory computer readable storage medium having a computer program stored thereon, wherein the computer program is executed by a processor to implement the following steps:

[0037] receive, from the at least one terminal, the Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0038] obtain, according to the Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0039] obtain, according to the ultrasound data of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages, the prediction result of whether the subject has the gastrointestinal symptom by using a preset determination standard;

[0040] send the prediction result of whether the subject has the gastrointestinal symptom to the at least one terminal.

[0041] The present application also provides a computer program product, which comprises a computer program, the computer program can be stored on a non-transitory computer readable storage medium, and the computer program can be executed by a processor to enable a computer to perform the following steps:

[0042] receive, from the at least one terminal, the Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0043] obtain, according to the Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages, the ultrasound data of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0044] obtain, according to the ultrasound data of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages, the prediction result of whether the subject has the gastrointestinal symptom by using a preset determination standard;

[0045] send the prediction result of whether the subject has the gastrointestinal symptom to the at least one terminal.

[0046] It should be noted that the terminal refers to an input and output device connected to the computer system, and according to different functions, the terminal can be divided into various types: smart terminal or intelligent terminal, dumb terminal, interactive terminal or online terminal, and the terminal can be various mobile communication devices such as mobile phones and tablet computers, which are intended to provide the user with the function of inputting and outputting data.

[0047] The gastrointestinal symptom prediction system provided by the present application compares the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the to-be-tested person with the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn population without gastrointestinal symptoms and the newborn population with gastrointestinal symptoms, so as to accurately predict whether the to-be-tested newborn has gastrointestinal symptoms, help to deeply understand the gastrointestinal condition of the newborn, provide reliable data guidance for the clinical nursing of the newborn, and reduce the probability of the newborn suffering from gastrointestinal diseases. BRIEF DESCRIPTION OF DRAWINGS

[0048] In order to more clearly illustrate the technical solutions in the present application or prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description are some embodiments of the present application, and those skilled in the art can obtain other drawings according to these drawings without creative labor.

[0049] Figure 1 The structural schematic diagram of the gastrointestinal symptom prediction model construction system provided by the present application.

[0050] Figure 2A The comparison schematic diagram of the PSV of SMA and MCA of the experimental group and the control group, Figure 2B The comparison schematic diagram of the EDV of SMA and MCA of the experimental group and the control group, Figure 2C The comparison schematic diagram of the RI of SMA and MCA of the experimental group and the control group.

[0051] Figure 3 The second comparison schematic diagram of the RI of SMA and MCA of the experimental group and the control group.

[0052] Figure 4 The structural schematic diagram of the electronic device provided by the present application. DETAILED DESCRIPTION

[0053] In order to make the purpose, technical solutions and advantages of the present application more clear, the technical solutions in the present application will be described clearly and completely in the following combined with the drawings in the present application. Obviously, the described embodiments are some embodiments of the present application, not all the embodiments, and they should not be understood as the limitation of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the protection scope of the present application. In the description of the present application, it should be understood that the terms used are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0054] Figure 1A structural schematic diagram of a gastrointestinal symptom prediction system provided by the present application.

[0055] Referring to Figure 1 The gastrointestinal symptom prediction system provided by the present application can include:

[0056] The first data receiving module is configured to receive, from the at least one terminal, the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages, wherein the subject is a neonate.

[0057] The first data processing module is configured to obtain, according to the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages, the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, wherein, in the present embodiment, the superior mesenteric artery ultrasound data includes any one or any combination of the following: the superior mesenteric artery systolic peak flow rate, the superior mesenteric artery diastolic minimum flow rate, and the superior mesenteric artery resistance index, and the different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth.

[0058] The prediction module is configured to obtain, according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, the prediction result of whether the subject has gastrointestinal symptoms by using a preset determination standard.

[0059] The data output module is configured to send the prediction result of whether the subject has gastrointestinal symptoms to the at least one terminal.

[0060] In one embodiment, the prediction module includes:

[0061] The trend obtaining submodule is configured to obtain, according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject.

[0062] The determination submodule is configured to compare, according to the preset determination standard, the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject with the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of a group of neonates without gastrointestinal symptoms and a group of neonates with gastrointestinal symptoms corresponding to the gestational age range, to obtain the prediction result of whether the subject has gastrointestinal symptoms.

[0063] The change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the group of neonates without gastrointestinal symptoms and the group of neonates with gastrointestinal symptoms corresponding to the gestational age range can include:

[0064] The peak systolic velocity of the middle cerebral artery and the minimum diastolic velocity of the middle cerebral artery of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms increase from the first day after birth to the seventh day after birth, and the middle cerebral artery resistance index decreases;

[0065] The superior mesenteric artery resistance index of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms increases on the first day after birth, the superior mesenteric artery resistance index of the group of newborns without gastrointestinal symptoms increases on the third day after birth and the seventh day after birth, and the superior mesenteric artery resistance index of the group of newborns with gastrointestinal symptoms decreases;

[0066] The peak systolic velocity of the superior mesenteric artery of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms increases from the first day after birth to the seventh day after birth, the minimum diastolic velocity of the superior mesenteric artery of the group of newborns with gastrointestinal symptoms is greater than that of the group of newborns without gastrointestinal symptoms on the third day after birth and the seventh day after birth, and the superior mesenteric artery resistance index of the group of newborns with gastrointestinal symptoms is less than that of the group of newborns without gastrointestinal symptoms;

[0067] The superior mesenteric artery resistance index of the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms is less than the middle cerebral artery resistance index on the first day after birth, the superior mesenteric artery resistance index of the group of newborns with gastrointestinal symptoms is greater than the middle cerebral artery resistance index on the third day after birth and the seventh day after birth, and the superior mesenteric artery resistance index of the group of newborns without gastrointestinal symptoms is less than the middle cerebral artery resistance index.

[0068] Specifically, the preset determination criteria include: when the change trend of the superior mesenteric artery ultrasound data of the to-be-tested person and the change trend of the middle cerebral artery ultrasound data are consistent with the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the group of newborns without gastrointestinal symptoms corresponding to the gestational age range, it is determined that the to-be-tested person has not appeared gastrointestinal symptoms, and when the change trend of the superior mesenteric artery ultrasound data of the to-be-tested person and the change trend of the middle cerebral artery ultrasound data are consistent with the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the group of newborns with gastrointestinal symptoms corresponding to the gestational age range, it is determined that the to-be-tested person has appeared gastrointestinal symptoms.

[0069] In the use of the gastrointestinal symptom prediction system, medical staff can obtain the mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the newborn at different gestational ages in advance and input them into the gastrointestinal symptom prediction system, which is received by the first data receiving module and processed and predicted by the first data processing module and the prediction module, and then output by the data output module to obtain the prediction result of whether the subject has gastrointestinal symptoms. Medical staff can formulate appropriate nursing plans for the newborn according to the prediction result output by the gastrointestinal symptom prediction system and their own judgment of the newborn, which can improve the work efficiency of medical staff and the accuracy of nursing plans, so as to ensure the reasonable care of the newborn and reduce the probability of the newborn getting sick.

[0070] In an embodiment, the gastrointestinal symptom prediction system can further comprise:

[0071] The first cause analysis module is configured to, when the prediction result is that the subject has gastrointestinal symptoms, obtain the cause of the gastrointestinal symptoms of the subject according to the diastolic minimum flow rate of the mesenteric artery of the subject.

[0072] In an embodiment, the gastrointestinal symptom prediction system can further comprise:

[0073] The second data receiving module is configured to receive the gastric bubble sonogram of the subject before and after feeding.

[0074] The second data processing module is configured to obtain the gastric emptying rate and the gastric emptying time of the subject according to the gastric bubble sonogram of the subject before and after feeding.

[0075] The second cause analysis module is configured to, when the prediction result is that the subject has gastrointestinal symptoms, obtain the cause of the gastrointestinal symptoms of the subject in combination with the gastric emptying rate and the gastric emptying time of the subject.

[0076] The present embodiment selects 176 cases of newborns treated in Beijing Chaoyang Hospital Affiliated to Capital Medical University from January 2018 to January 2023, of which 90 cases are male and 86 cases are female. Through the inclusion and exclusion criteria, the enrolled children are divided into two groups. The gastrointestinal symptoms during hospitalization are the experimental group (i.e. the group of newborns with gastrointestinal symptoms), and the control group is the group of newborns without gastrointestinal symptoms during hospitalization. Color Doppler ultrasound is used to measure the superior mesenteric artery (SMA) and middle cerebral artery (MCA) of the children on the first day, third day and seventh day after birth. The peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index (RI) of the two are compared respectively. The results show that there are statistical differences in the comparison of SMA in different time periods between the experimental group and the control group, and there are also statistical differences in SMA between different time periods in the same group of children (statistical value: P value). MCA only has statistical differences between different time periods in the same group of children (statistical value: P value). The PSV and EDV of MCA slowly increase over time, and the RI decreases, and the RI decreases to below 0.80 from the third day to the seventh day. The PSV of SMA in the experimental group and the control group slowly increases, and there are differences in EDV and RI between the experimental group and the control group (statistical value: P value). The EDV of the experimental group is greater than that of the control group on the third day and the seventh day, and the RI of the experimental group is less than that of the control group on the third day and the seventh day. If the RI of SMA and MCA is compared, the RI value of SMA is less than that of MCA in the experimental group and the control group on the first day after birth; a change occurs on the third day and the seventh day after birth, the RI value of SMA in the experimental group is greater than that of MCA, and the RI value of SMA in the control group is less than that of MCA (statistical value: P value). Therefore, the present invention believes that color Doppler ultrasound monitoring of the hemodynamic changes of the superior mesenteric artery and the gastric emptying condition can play an important role in the gastrointestinal diseases of premature infants.

[0077] Therefore, the present embodiment includes the superior mesenteric artery ultrasound data of the 176 newborns. Among them, the gestational age is 28-34 weeks, and the average gestational age is (28.13±5.6) weeks; the average weight is (1.36±0.57) kg. The inclusion criteria are: (1) diagnosis: the children meet the diagnosis of premature infants and very low birth weight infants; (2) the children's families sign the informed consent form; (3) color Doppler ultrasound monitoring of the superior mesenteric artery (SMA) and middle cerebral artery (MCA) hemodynamics operation. The exclusion criteria are: (1) children with birth defects and congenital diseases; (2) children who cannot undergo ultrasound examination due to various factors. The enrolled children are divided into two groups. The experimental group has gastrointestinal symptoms (including: abdominal distension, hematochezia, abdominal tenderness or stiffness [1-4]) during hospitalization, and the control group has no gastrointestinal symptoms during hospitalization. All patients are treated according to the doctor's advice, including warming, respiratory support, prevention and treatment of infection, symptomatic support, etc.

[0078] The Doppler color ultrasound instrument (Japan, Japan) with 7.5 MHz imaging and 5 MHz Doppler transducer was used to measure the superior mesenteric artery. The linear array probe (2-9 MHz) or small convex array probe (2-8 MHz) was selected. The child was in a supine position, and the probe was placed under the xiphoid process of the child. The small convex array probe (2-8 MHz) was selected to measure the middle cerebral artery. The probe was placed in the temporal part of the child. Clear images of the blood vessels were obtained in real-time ultrasound, and corrections were made for the incident angle. According to the recorded Doppler tracing, the peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), and resistance index (RI) were obtained from the peak velocity envelope cycle of the heart for 5 consecutive times. It should be noted that the Doppler ultrasound measurement of the superior mesenteric artery is in the stable period of heart and lung (defined as mean arterial blood pressure of 30 mmHg, continuous oxygen saturation monitoring of 88%-95%, and / or recent blood gas shows pH value of 7.25, PaCO2 of 4.6-7 kPa and PaO2 of 7-10 kPa).

[0079] The linear array probe (2-9 MHz) was selected. The child was in a supine position, and the probe was placed under the left costal part of the child, below the spleen, to display the gastric bubble sonogram. The volume was calculated by taking the maximum diameter of the cross-section and the longitudinal section to obtain the gastric content volume. The measurement was taken before feeding, immediately after feeding, every 5 minutes after feeding, until the gastric content volume and the volume before feeding were the same and no longer changed, usually before the next feeding. The 5-minute gastric emptying rate and gastric emptying time were calculated.

[0080] SPSS 26.0 statistical software was used to statistically analyze all the data. The measurement data conforming to the normal distribution were represented by mean ± standard deviation, and the non-normal distribution data were represented by quartiles. For measurement data conforming to the normal distribution, t-test was used for comparison of data between two groups; for measurement data not conforming to the normal distribution, Mann-Whitney U rank sum test was used for comparison of data between two groups. P<0.05 was considered statistically significant.

[0081] The multiple comparisons of the experimental group and the control group are shown in Table 1. There was no statistically significant difference in body weight; there was a statistically significant difference in gestational age. The PSV, EDV and RI of the experimental group and the control group were compared on the first day, the third day and the seventh day, respectively. The results showed that there were statistically significant differences in SMA between the experimental group and the control group at different time periods, and there were also statistically significant differences in SMA between different time periods of the same group of children; MCA only had statistically significant differences between different time periods of the same group of children.

[0082] Table 1. Comparison of SMA and MCA between experimental group and control group

[0083]

[0084]

[0085] Note: *: PSV comparison; **: EDV comparison; ***: RI comparison

[0086] The change trend of PSV, EDV and RI of SMA and MCA between experimental group and control group is shown in FIGS. Figure 2A , 2B , 2C, it can be seen that whether it is an experimental group or a control group, the PSV and EDV of MCA slowly increase with time, and the RI decreases, and the RI decreases to below 0.80 from the third day to the seventh day; the PSV of the experimental group and the control group of SMA slowly increases, and the EDV and RI are different between the experimental group and the control group, the EDV of the experimental group is greater than that of the control group at the third day and the seventh day, and the RI of the experimental group is less than that of the control group at the third day and the seventh day.

[0087] If the RIs of SMA and MCA are compared (as shown in Table 2), it can be found that the RI value of SMA is less than that of MCA in the experimental group and the control group on the first day after birth; a change occurs on the third day and the seventh day after birth, the RI value of SMA in the experimental group is greater than that of MCA, and the RI value of SMA in the control group is less than that of MCA; the RI value of SMA in the experimental group is decreased, and that in the control group is increased (as shown in Figure 3 ).

[0088] Table 2. Comparison of RI of SMA and MCA

[0089]

[0090] Note: *: experimental group comparison; **: control group comparison

[0091] In this embodiment, the change trend of the superior mesenteric artery ultrasound data of the subject at different gestational ages is compared with the change trend of the superior mesenteric artery ultrasound data of the population of newborns without gastrointestinal symptoms and the population of newborns with gastrointestinal symptoms corresponding to the gestational age range, which can accurately predict whether the newborn to be tested has gastrointestinal symptoms, helps to deeply understand the gastrointestinal condition of the newborn, provides reliable data guidance for the clinical nursing of the newborn, and reduces the probability of the newborn suffering from gastrointestinal diseases.

[0092] Premature infants, especially very low birth weight infants, are an important part of the patients in the neonatal intensive care unit (NICU), and due to their own immaturity, they need to be placed with a gastric tube for a long time for treatment and feeding. Premature infants have slower gastric emptying, higher reflux rates, and more feeding-related apnea. The embodiment shows that the perfusion flow rate of the superior mesenteric artery in the early stage of birth is low, and the resistance index is high; as the time of birth is prolonged, the intestinal perfusion flow rate of the newborn slowly rises, the resistance index gradually rises, and is higher than the resistance index of the middle cerebral artery, and gradually approaches that of normal children, but if the child has gastrointestinal symptoms, the resistance index will tend to be flat, less than the resistance index of the middle cerebral artery, and the blood in the intestinal vessels will stagnate. This also confirms that premature infants have small stomach capacity, poor gastrointestinal motility, are prone to vomiting, abdominal distension, and gastric retention, and even necrotizing enterocolitis.

[0093] Children, especially newborns, develop rapidly, whether they improve or worsen, often in an instant. The embodiment effectively combines the color Doppler of the superior mesenteric artery and the middle cerebral artery. On the one hand, MCA has now become a routine examination item for newborns, and pediatric ultrasound doctors can master it very skillfully. The SMA measurement time is selected at one day, three days, and seven days after birth in order to correspond to the internationally recognized examination time of the brain, so as to facilitate the comparison of the results of the superior mesenteric artery and the results of the brain color Doppler. On the other hand, the middle cerebral artery itself is a project that deserves close attention in newborns, especially premature infants, as it changes quickly and has high sensitivity. MCA can early reflect various neonatal brain diseases such as hypoxic-ischemic encephalopathy and brain edema.

[0094] PSV is the highest flow rate in the systolic phase, that is, the highest blood flow per second, which can feedback the blood flow of organ perfusion; EDV is the lowest flow rate in the diastolic phase, that is, the blood flow after the blood vessels dilate. The embodiment shows that when the child has gastrointestinal symptoms, the EDV flow rate of the experimental group is higher than that of the control group, that is, blood stasis occurs, from which it can be inferred that the cause of premature infant gastrointestinal complications is intestinal blood stasis and decreased intestinal blood circulation speed.

[0095] Figure 4 An example of a schematic diagram of the physical structure of an electronic device is shown in Figure 4 The electronic device can include a processor 810, a communications interface 820, a memory 830, and a communications bus 840, wherein the processor 810, the communications interface 820, and the memory 830 complete mutual communication through the communications bus 840. The processor 810 can invoke the logical instructions in the memory 830 to perform the following steps:

[0096] receive, from the at least one terminal, the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages;

[0097] obtain superior mesenteric artery ultrasound data and middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages;

[0098] obtain the prediction result of whether the subject has the gastrointestinal symptom according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and by using a preset determination standard;

[0099] send the prediction result of whether the subject has the gastrointestinal symptom to the at least one terminal.

[0100] In addition, the logic instructions in the memory 830 described above can be implemented in the form of a software function unit and sold or used as an independent product, and can be stored in a computer readable storage medium. Based on such understanding, the technical solutions of the present application essentially or the part that contributes to the prior art or part of the technical solutions can be embodied in the form of a software product. The computer software product is stored in a storage medium, and includes a plurality of instructions for causing a computer device (which can be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of the present application. The aforementioned storage medium includes: a U disk, a mobile hard disk, a read-only memory (ROM, Read-Only Memory), a random access memory (RAM, Random Access Memory), a magnetic disk or an optical disk, and various program code storage media.

[0101] On the other hand, the present application also provides a computer program product, which comprises a computer program, the computer program can be stored on a non-transitory computer readable storage medium, and the computer program can be executed by a processor, so that the computer can execute the following steps:

[0102] receive, from the at least one terminal, the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages;

[0103] obtain superior mesenteric artery ultrasound data and middle cerebral artery ultrasound data of the subject at different gestational ages according to the superior mesenteric artery Doppler ultrasound image and the middle cerebral artery Doppler ultrasound image of the subject at different gestational ages;

[0104] obtain the prediction result of whether the subject has the gastrointestinal symptom according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and by using a preset determination standard;

[0105] send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal. In another aspect, the present application also provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements the following steps:

[0106] receive, from at least one terminal, the Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0107] obtain the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages according to the Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of the subject at different gestational ages;

[0108] obtain the prediction result of whether the subject has gastrointestinal symptoms according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, using a preset determination standard;

[0109] send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal.

[0110] The apparatus embodiments described above are merely illustrative, wherein the units described as separate components can or can not be physically separate, and the components displayed as units can or can not be physical units, i.e., can be located in one place, or can be distributed on multiple network units. Part or all of the modules can be selected to achieve the purpose of the present embodiment according to actual needs. Those skilled in the art can understand and implement without creative labor.

[0111] From the above description of the embodiments, those skilled in the art can clearly understand that the embodiments can be realized by means of software plus necessary general hardware platforms, and of course can also be realized by hardware. Based on such understanding, the above technical solutions, essentially or in other words, the part that contributes to the prior art, can be embodied in the form of a software product, which can be stored in a computer readable storage medium, such as a ROM / RAM, a magnetic disk, an optical disk, etc., and includes a number of instructions to make a computer device (which can be a personal computer, a server, or a network device, etc.) execute the methods described in the various embodiments or some parts of the embodiments.

[0112] It should be pointed out finally that the above embodiments are only used to illustrate the technical solutions of the present application, but not to limit the same; and although the present application has been described in detail with reference to the foregoing embodiments, it should be appreciated by those skilled in the art that the technical solutions recorded in the foregoing embodiments can be modified, or some technical features thereof can be replaced equivalently; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. A gastrointestinal symptom prediction system, characterized in that: include: The first data receiving module is configured to receive, from at least one terminal, Doppler ultrasound images of the superior mesenteric artery and the middle cerebral artery of a subject at different gestational ages, wherein the subject is a newborn; The first data processing module is configured to obtain the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages based on the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages; The prediction module is used to: obtain a prediction result of whether the subject has gastrointestinal symptoms based on the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages using preset judgment criteria; A data output module is used to: send the prediction result of whether the subject has gastrointestinal symptoms to at least one terminal; Among them, the prediction module includes: The trend obtaining submodule is used to obtain the change trend of the superior mesenteric artery ultrasound data and the change trend of the middle cerebral artery ultrasound data of the subject according to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages; a determination submodule, configured to compare, based on preset determination criteria, the changing trends of the superior mesenteric artery ultrasound data and the changing trends of the middle cerebral artery ultrasound data of the subject with the changing trends of the superior mesenteric artery ultrasound data and the changing trends of the middle cerebral artery ultrasound data of the subject within the corresponding gestational age range of a group of newborns without gastrointestinal symptoms and a group of newborns with gastrointestinal symptoms, to obtain a prediction result of whether the subject has gastrointestinal symptoms; The superior mesenteric artery ultrasound data include any one of the following or any combination thereof: the highest systolic velocity of the superior mesenteric artery, the lowest diastolic velocity of the superior mesenteric artery, and the superior mesenteric artery resistance index; the middle cerebral artery ultrasound data include any one of the following or any combination thereof: the highest systolic velocity of the middle cerebral artery, the lowest diastolic velocity of the middle cerebral artery, and the middle cerebral artery resistance index; Among them, different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth; Among them, the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age ranges of the newborn groups without gastrointestinal symptoms and the newborn groups with gastrointestinal symptoms include: On the first day after birth, the superior mesenteric artery resistance index of both the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms was lower than the middle cerebral artery resistance index. On the third and seventh days after birth, the superior mesenteric artery resistance index of the newborn group with gastrointestinal symptoms was higher than the middle cerebral artery resistance index, while the superior mesenteric artery resistance index of the newborn group without gastrointestinal symptoms was lower than the middle cerebral artery resistance index.

2. The gastrointestinal symptom prediction system according to claim 1, characterized in that: The changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age ranges for the newborn groups without gastrointestinal symptoms and the newborn groups with gastrointestinal symptoms include: On the first day after birth, the superior mesenteric artery resistance index increased in the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms. On the third and seventh days after birth, the superior mesenteric artery resistance index increased in the group of newborns without gastrointestinal symptoms, while the superior mesenteric artery resistance index decreased in the group of newborns with gastrointestinal symptoms.

3. The gastrointestinal symptom prediction system according to claim 1, characterized in that: The changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age ranges for the newborn groups without gastrointestinal symptoms and the newborn groups with gastrointestinal symptoms include: From the first day to the seventh day after birth, the maximum systolic flow velocity of the superior mesenteric artery increased in both the group of newborns without gastrointestinal symptoms and the group of newborns with gastrointestinal symptoms. On the third and seventh days after birth, the minimum diastolic flow velocity of the superior mesenteric artery of the group of newborns with gastrointestinal symptoms was greater than that of the group of newborns without gastrointestinal symptoms, and the superior mesenteric artery resistance index of the group of newborns with gastrointestinal symptoms was lower than that of the group of newborns without gastrointestinal symptoms.

4. The gastrointestinal symptom prediction system according to any one of claims 1 to 3, characterized in that: The preset judgment criteria include: when the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the subject are consistent with the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the newborn group without gastrointestinal symptoms, it is judged that the subject has no gastrointestinal symptoms; when the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the subject are consistent with the changing trend of the superior mesenteric artery ultrasound data and the changing trend of the middle cerebral artery ultrasound data of the newborn group with gastrointestinal symptoms, it is judged that the subject has developed gastrointestinal symptoms.

5. An electronic device comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein: When the processor executes the program, the following steps are implemented: receiving, from at least one terminal, a superior mesenteric artery Doppler ultrasound image and a middle cerebral artery Doppler ultrasound image of a subject at different gestational ages, wherein the subject is a newborn; Obtaining superior mesenteric artery ultrasound data and middle cerebral artery ultrasound data of the subject at different gestational ages based on the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages; Based on the superior mesenteric artery ultrasound data and middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, a prediction result of whether the subject has gastrointestinal symptoms is obtained; Sending a prediction result of whether the subject has gastrointestinal symptoms to at least one terminal; The method of obtaining a prediction result of whether the subject has gastrointestinal symptoms based on the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and using a preset judgment standard includes: According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, a change trend of the superior mesenteric artery ultrasound data and a change trend of the middle cerebral artery ultrasound data of the subject are obtained; Based on the preset judgment criteria, the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the test subject are compared with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms to obtain the prediction result of whether the test subject has gastrointestinal symptoms; The superior mesenteric artery ultrasound data include any one of the following or any combination thereof: the highest systolic velocity of the superior mesenteric artery, the lowest diastolic velocity of the superior mesenteric artery, and the superior mesenteric artery resistance index; the middle cerebral artery ultrasound data include any one of the following or any combination thereof: the highest systolic velocity of the middle cerebral artery, the lowest diastolic velocity of the middle cerebral artery, and the middle cerebral artery resistance index; Among them, different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth; Among them, the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age ranges of the newborn groups without gastrointestinal symptoms and the newborn groups with gastrointestinal symptoms include: On the first day after birth, the superior mesenteric artery resistance index of both the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms was lower than the middle cerebral artery resistance index. On the third and seventh days after birth, the superior mesenteric artery resistance index of the newborn group with gastrointestinal symptoms was higher than the middle cerebral artery resistance index, while the superior mesenteric artery resistance index of the newborn group without gastrointestinal symptoms was lower than the middle cerebral artery resistance index.

6. A non-transitory computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the following steps are implemented: receiving, from at least one terminal, a superior mesenteric artery Doppler ultrasound image and a middle cerebral artery Doppler ultrasound image of a subject at different gestational ages, wherein the subject is a newborn; Obtaining superior mesenteric artery ultrasound data and middle cerebral artery ultrasound data of the subject at different gestational ages based on the superior mesenteric artery Doppler ultrasound images and the middle cerebral artery Doppler ultrasound images of the subject at different gestational ages; Based on the superior mesenteric artery ultrasound data and middle cerebral artery ultrasound data of the subject at different gestational ages, using the preset judgment criteria, a prediction result of whether the subject has gastrointestinal symptoms is obtained; Sending a prediction result of whether the subject has gastrointestinal symptoms to at least one terminal; The method of obtaining a prediction result of whether the subject has gastrointestinal symptoms based on the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages and using a preset judgment standard includes: According to the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the subject at different gestational ages, a change trend of the superior mesenteric artery ultrasound data and a change trend of the middle cerebral artery ultrasound data of the subject are obtained; Based on the preset judgment criteria, the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the test subject are compared with the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data of the corresponding gestational age range of the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms to obtain the prediction result of whether the test subject has gastrointestinal symptoms; The superior mesenteric artery ultrasound data include any one of the following or any combination thereof: the highest systolic velocity of the superior mesenteric artery, the lowest diastolic velocity of the superior mesenteric artery, and the superior mesenteric artery resistance index; the middle cerebral artery ultrasound data include any one of the following or any combination thereof: the highest systolic velocity of the middle cerebral artery, the lowest diastolic velocity of the middle cerebral artery, and the middle cerebral artery resistance index; Among them, different gestational ages include the first day after birth, the third day after birth, and the seventh day after birth; Among them, the changing trends of the superior mesenteric artery ultrasound data and the middle cerebral artery ultrasound data in the corresponding gestational age ranges of the newborn groups without gastrointestinal symptoms and the newborn groups with gastrointestinal symptoms include: On the first day after birth, the superior mesenteric artery resistance index of both the newborn group without gastrointestinal symptoms and the newborn group with gastrointestinal symptoms was lower than the middle cerebral artery resistance index. On the third and seventh days after birth, the superior mesenteric artery resistance index of the newborn group with gastrointestinal symptoms was higher than the middle cerebral artery resistance index, while the superior mesenteric artery resistance index of the newborn group without gastrointestinal symptoms was lower than the middle cerebral artery resistance index.

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