Methods of determining natural time progression of immune response and methods and compositions for altering intracellular pH to control disease

By regulating the pHi and MMP of lymphocytes and using energy metabolism regulators to control the natural time course of the immune response, the problem of difficulty in effectively controlling the immune response in the prior art is solved, and the fine regulation and efficient effect of immune diseases and cancer treatments are achieved.

CN120051275APending Publication Date: 2025-05-27THERAZWIMM CORP
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Patent Information

Application Number
CN202380072977.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2023-09-06
Filing Date
2023-10-17
Publication Date
2025-05-27

AI Technical Summary

Technical Problem

The prior art is difficult to effectively control the natural time course of the immune response, resulting in adverse side effects in the treatment of immune diseases and cancer.

Method used

By regulating the intracellular pH (pHi) and mitochondrial membrane potential (MMP) of lymphocytes, the natural time course of the immune response is controlled, and energy metabolism regulators such as pyruvate, fatty acids, amino acids, etc. are used to reduce or increase pHi, thereby regulating lymphocyte death and proliferation.

Benefits of technology

The fine regulation of the immune response has been achieved, the adverse side effects of immune diseases and cancer treatment have been reduced, and the treatment effect has been improved.

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Abstract

The present invention provides a method of determining a stage in a natural time progression of an immune response in an individual. It describes a method for controlling an immune response by a modulation mechanism for differential operation in lymphocytes at different stages in the natural time progress of the immune response. Wherein one regulating mechanism is an energy metabolism mechanism for controlling intracellular pH (pHi) so as to control cell death and proliferation. Also described are combined methods of reducing the pHi of tumor cells to induce death thereof using compositions combined by energy metabolism modulators. Finally, the present invention provides methods of treating skin or mucosal infections or neoplasia by topical administration of a pH regulator that reduces pH.
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