Traditional Chinese medicine composition and medicine for treating throat diseases as well as preparation method and application of traditional Chinese medicine composition and medicine

Abstract

The invention belongs to the technical field of traditional Chinese medicine research, and particularly relates to a traditional Chinese medicine composition for treating throat diseases, a medicine, a preparation method and application. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of scorpion, 15-25 parts of borneol and 55-65 parts of lithospermum erythrorhizon. The traditional Chinese medicine composition provided by the invention has a good curative effect on throat diseases, especially acute and chronic pharyngitis and acute and chronic tonsillitis.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine research, and particularly relates to a traditional Chinese medicine composition for treating throat diseases, a medicine, a preparation method, and an application thereof. Background Art

[0002] Physiologically, the throat refers to the larynx, including the pharynx, the upper part of the esophagus, the larynx, and the passages of the trachea leading to the stomach and lungs, and the upper front part of the neck adjacent to the cheeks. The throat is an organ for eating, breathing, and making sounds. The throat connects the mouth and nose above and the lungs and stomach below, is a passage connecting the oral cavity and the lungs and stomach, and is also a key point for the circulation of meridians. There are many types of throat diseases, and the common ones are as follows: (1) Foreign body stuck in the throat. If when eating foods such as fish and nuts, a fish bone or a sharp substance such as a nut shell is accidentally swallowed and stuck in the throat, the disease of foreign body stuck in the throat will occur. At this time, the foreign body in the throat needs to be removed as soon as possible to effectively restore ventilation. (2) Acute pharyngitis or chronic pharyngitis. After being infected by viruses or bacteria, and under the influence of rhinitis and gastroesophageal reflux disease, acute pharyngitis and chronic pharyngitis may occur. Patients will show discomfort such as congestion, edema, pain, and burning in the throat.

[0003] At present, there are still many technical deficiencies in the treatment of throat diseases. Modern medicine mostly uses antibiotics to treat common throat diseases such as pharyngitis and tonsillitis. However, the long-term and extensive use of antibiotics is likely to cause the problem of bacterial drug resistance, making the subsequent treatment of infections more difficult. Moreover, while antibiotics kill harmful bacteria, they also disrupt the normal flora balance in the human throat, which may lead to secondary infections and prolong the recovery period of patients. In terms of symptomatic treatment, for throat pain, common antipyretic and analgesic drugs can only relieve the pain temporarily and cannot fundamentally solve the cause. Once the drug effect passes, the pain often recurs. And some drugs are also accompanied by side effects such as gastrointestinal irritation, bringing additional burdens to patients, especially those with poor gastrointestinal function. Summary of the Invention

[0004] Based on the above technical problems, the present invention provides a traditional Chinese medicine composition for treating throat diseases. This traditional Chinese medicine composition has good curative effects on throat diseases, especially acute and chronic pharyngitis and acute and chronic tonsillitis, and has low toxicity and side effects.

[0005] The technical solution provided by the present invention is as follows: In the first aspect of the present invention, a traditional Chinese medicine composition for treating throat diseases is provided, which is prepared from the following raw materials by weight: 15 - 25 parts of scorpion, 15 - 25 parts of borneol, and 55 - 65 parts of lithospermum root.

[0006] As a preferred embodiment of the present invention, the traditional Chinese medicine composition is made from the following raw materials by weight: 20 parts of scorpion, 20 parts of borneol, and 60 parts of Arnebia euchroma (Royle) Johnst.

[0007] More preferably, the Arnebia euchroma (Royle) Johnst. is Arnebia euchroma (Royle) Johnst. from Xinjiang.

[0008] In the second aspect of the present invention, a preparation method of the traditional Chinese medicine composition is provided, including the following steps: Weigh scorpion, borneol, and Arnebia euchroma (Royle) Johnst. according to the weight parts and set aside; Crush the dried scorpion and Arnebia euchroma (Royle) Johnst., then mix with borneol, crush again, and sieve to obtain the product.

[0009] As a preferred embodiment of the present invention, the drying is carried out at 60 °C for 4 - 8 hours.

[0010] In the third aspect of the present invention, a use of the traditional Chinese medicine composition in the preparation of a drug for treating throat-related diseases is provided.

[0011] As a preferred embodiment of the present invention, the traditional Chinese medicine composition is used for the preparation of a drug for treating acute and chronic pharyngitis.

[0012] As a preferred embodiment of the present invention, the traditional Chinese medicine composition is used for the preparation of a drug for treating acute and chronic tonsillitis.

[0013] In the fourth aspect of the present invention, a drug for treating throat-related diseases is provided, and the drug uses the traditional Chinese medicine composition as the only effective active ingredient.

[0014] As a preferred embodiment of the present invention, the drug is prepared by mixing the traditional Chinese medicine composition with pharmaceutically acceptable traditional excipients.

[0015] As a preferred embodiment of the present invention, the drug is an external preparation.

[0016] More preferably, the drug is a powder. The powder is prepared into the traditional Chinese medicine composition according to the above method. When in use, it is mixed with sesame oil and then applied to specific acupoints in the pharynx. Specifically, it is applied to the bilateral Renying acupoints.

[0017] Scorpion has analgesic effect and antithrombotic effect. It is commonly used in the treatment of: 1. Epilepsy, tetanus and other diseases; 2. Headache, rheumatic arthralgia and other diseases; 3. Swelling and pain of sores and ulcers. Scorpion powder is used externally for acupoint application therapy. Although it is a toxic traditional Chinese medicine, it has the effects of attacking toxins and resolving masses, promoting blood circulation and removing blood stasis, and detumescence and relieving pain. The medicinal efficacy can reach the lesion through acupoints and meridians, achieving the effect of using poison to fight poison. Scorpion contains many organic acids, proteins, etc. Fresh scorpion contains proteins and non-protein elements such as scorpion venom, taurine, palmitic acid, trimethylamine, betaine, lecithin, stearic acid and oleic acid. It contains free amino acids essential to the body, and its action effect has the effects of antipyretic, anti-inflammatory, anti-fatigue, analgesic, regulating body immunity, and resisting rheumatism. It is often used in the diagnosis and treatment of pharyngeal inflammatory pain.

[0018] Modern pharmacological studies on Lithospermum erythrorhizon (from Xinjiang) have proved the following functions: 1. Anti-inflammatory effect; 2. Effect of inhibiting pathogenic microorganisms; 3. Effect on blood coagulation and hemostatic effect; 4. Effect of increasing cellular immunity when applied locally; 5. Hormone-like effect when applied locally and can increase platelets. Lithospermum erythrorhizon (from Xinjiang) has a variety of pharmacological activities, such as antibacterial, antiviral, promoting wound healing, anti-tumor, etc., and is widely used clinically.

[0019] Borneol is an important pain-relieving drug in traditional Chinese medicine in China. External application of borneol can affect a certain link of pain conduction and can reduce the nociceptive stimulus signals transmitted by pain receptors in the pain area to the spinal cord; because traditional Chinese medicine believes that the efficacy of borneol is clearing heat and relieving pain, it can be clinically used to treat throat obstruction and oral ulcers; modern pharmacological studies have proved that borneol contains two isomers, borneol and isoborneol, and borneol is the main pharmacological active ingredient of borneol. Borneol has antibacterial, antiviral, antifungal, analgesic and other effects. At the same time, borneol can promote the transdermal absorption rate and bioavailability of other drugs, reduce the elimination of other drugs in the liver, and prolong the drug action time.

[0020] The traditional Chinese medicine composition provided by the present invention is composed of scorpion, lithospermum root, and borneol. In the formula, scorpion can extinguish wind and stop convulsion, dredge collaterals and relieve pain, and attack toxin and disperse mass, thereby reducing the congestion and inflammatory reaction of pharyngeal mucosa. Its effect of attacking toxin and disperse mass is relatively strong and it is commonly used for treating sores and ulcers, usually applied externally, and it is the monarch drug; lithospermum root can clear heat and cool blood, activate blood circulation and detoxify, and promote eruption and eliminate macula, and it is the minister drug; borneol can clear heat and relieve pain, and open orifices and restore consciousness, thereby relieving the pain and congestion symptoms of the pharynx, and it is the assistant drug. The combination of the three drugs can clear heat and detoxify, activate blood circulation and remove stasis, soften hardness and disperse mass, and relieve swelling and pain, and can be used for laryngeal diseases such as acute pharyngitis, chronic pharyngitis, acute tonsillitis, chronic tonsillitis, aphonia, laryngeal abscess, and cervical abscess. The cooperation of several traditional Chinese medicines can weaken local inflammatory pain, improve the immune effect of the body, and at the same time promote the excretion of immunoglobulin in saliva to improve the oral environment. Applying lithospermum root, scorpion, and lithospermum root indirectly acts on pharyngeal lymph nodes through local drug penetration of Lianquan acupoint, with bactericidal and bacteriostatic effects, making the local inflammation of pharyngeal mucosa subside, and fundamentally and thoroughly solving the problem of difficult-to-eliminate inflammation recurrence. The dual effects of local stimulation of meridian acupoints and transdermal absorption of traditional Chinese medicine achieve the effect of taking both the root cause and symptoms into consideration. The formula is made into a powder, mixed with sesame oil, and applied to the larynx, which is convenient for patients to carry and use, and can ensure the curative effect. Moreover, the formula is composed of traditional Chinese medicine raw materials and has the characteristics of low side effects. Detailed implementation mode

[0021] The technical solutions in the embodiments of the present invention are further clearly described. The described embodiments are only a part of the present invention, used to explain the present invention, but not to limit the present invention. Therefore, other embodiments obtained by those skilled in the art without creative labor belong to the protection scope of the present invention.

[0022] Physiologically, the throat refers to the larynx, including the pharynx, the upper part of the esophagus, the larynx, and the passages of the trachea leading to the stomach and lungs, and the upper front part of the neck adjacent to the cheek. There are many types of throat diseases, and acute pharyngitis or chronic pharyngitis is one of them.

[0023] For common throat diseases such as pharyngitis and tonsillitis, modern medicine mostly uses antibiotics for treatment. However, the long-term and extensive use of antibiotics is likely to cause bacterial drug resistance problems, making subsequent infection treatment more difficult. Moreover, while antibiotics kill harmful bacteria, they also disrupt the normal flora balance in the human throat, which may lead to secondary infections and prolong the patient's recovery period. In terms of symptomatic treatment, for throat pain, common antipyretic and analgesic drugs can only temporarily relieve the pain but cannot fundamentally solve the cause. Once the drug effect wears off, the pain often recurs. And some drugs also have side effects such as gastrointestinal irritation, bringing additional burdens to patients, especially those with poor gastrointestinal function. From the perspective of local treatment methods, the atomization inhalation therapy has certain limitations. The equipment operation is relatively complex, and patients need to receive treatment at specific places and specific times, with poor compliance. Although throat sprays are convenient to use, the drug residence time is short, and it is difficult to deeply penetrate to the lesion site to exert continuous drug effects. Some traditional Chinese medicine preparations in traditional Chinese medicine treatment methods have relatively single effects and limited improvement effects on complex throat diseases.

[0024] Based on this, the present invention provides a traditional Chinese medicine composition for treating throat diseases, which is prepared from the following raw materials by weight: 15-25 parts of scorpion, 15-25 parts of borneol, and 55-65 parts of lithospermum root. This traditional Chinese medicine composition can be used for laryngeal diseases such as acute pharyngitis, chronic pharyngitis, acute tonsillitis, chronic tonsillitis, aphonia, laryngeal abscess, and cervical abscess.

[0025] As a preferred embodiment of the present invention, the lithospermum root used in the present invention is selected from Arnebia euchroma (Royle) Johnst.

[0026] Example 1 A traditional Chinese medicine composition for treating throat diseases is prepared from the following raw materials: 15 g of scorpion, 15 g of borneol, and 55 g of Arnebia euchroma (Royle) Johnst.

[0027] The preparation method of this traditional Chinese medicine composition is as follows: Bake the scorpion at 60 °C for 8 hours, bake the Arnebia euchroma (Royle) Johnst at 60 °C for 4 hours, weigh the medicinal materials according to the formula, mix and pulverize them, add borneol and mix and pulverize again, and then sieve them to obtain the product. When in use, mix it with sesame oil and apply it to the patient's throat.

[0028] Example 2 A traditional Chinese medicine composition for treating throat diseases is prepared from the following raw materials: 20 g of scorpion, 20 g of borneol, and 60 g of Arnebia euchroma (Royle) Johnst.

[0029] The preparation method of this traditional Chinese medicine composition is as follows: Bake the scorpion at 60 °C for 8 hours, bake the Arnebia euchroma (Royle) Johnst at 60 °C for 4 hours, weigh the medicinal materials according to the formula, mix and pulverize them, add borneol and mix and pulverize again, and then sieve them to obtain the product. When in use, mix it with sesame oil and apply it to the patient's throat.

[0030] Example 3 A traditional Chinese medicine composition for treating throat diseases, which is made from the following raw materials: 25 g of scorpion, 25 g of borneol, and 65 g of Arnebia euchroma (Royle) Johnst.

[0031] The preparation method of the traditional Chinese medicine composition is as follows: Bake the scorpion at 60 °C for 8 hours, bake the Arnebia euchroma (Royle) Johnst. at 60 °C for 4 hours, weigh the medicinal materials according to the formula, mix them evenly, pulverize, add borneol and mix and pulverize, and then sieve. When in use, mix with sesame oil and apply it to the patient's throat.

[0032] Example 4 A traditional Chinese medicine composition for treating throat diseases, which is made from the following raw materials: 22 g of scorpion, 20 g of borneol, and 60 g of Arnebia euchroma (Royle) Johnst.

[0033] The preparation method of the traditional Chinese medicine composition is as follows: Bake the scorpion at 60 °C for 8 hours, bake the Arnebia euchroma (Royle) Johnst. at 60 °C for 4 hours, weigh the medicinal materials according to the formula, mix them evenly, pulverize, add borneol and mix and pulverize, and then sieve. When in use, mix with sesame oil and apply it to the patient's throat.

[0034] Since the effects of the traditional Chinese medicine compositions provided in Examples 1 to 4 are basically the same, the traditional Chinese medicine composition provided in Example 2 is taken as an example for effect description in the present invention.

[0035] Clinical pharmacodynamic test 1. Observation objects Select 100 patients diagnosed with acute tonsillitis for clinical observation. The main symptoms are: sore throat, fever, dry throat, foreign body sensation in the throat, sense of pharyngeal blockage, expectoration, and cough. The main signs are: size of the tonsils, tonsillar congestion, tonsillar secretions, congestion and swelling of the pharyngeal lateral bands, and hyperplasia of the lymphoid follicles on the posterior pharyngeal wall. Randomly divide them into a treatment group and a control group. The gender, age, and condition of the two groups of cases in the treatment group and the control group are basically the same, with no significant difference, and they are comparable.

[0036] 2. Treatment methods Randomly divide the patients with acute exacerbation of chronic tonsillitis who meet the inclusion criteria into two groups. On the basis of both groups of patients being given routine basic nursing, the treatment group is given amoxicillin and clavulanate potassium granules combined with the traditional Chinese medicine composition provided in Example 2 of the present invention (take 3 g of the medicinal powder, mix it evenly with 1.5 g of sesame oil, put the medicine into the acupoint patch, apply it to the bilateral Renying acupoints once a day for 3 hours), and the control group is given oral amoxicillin and clavulanate potassium dispersible tablets (0.375 g, orally, once every 8 hours). Observe the changes in the symptoms and signs of the two groups of patients before and after treatment and record them, and conduct an objective and scientific evaluation of the observation results.

[0037] 3. Treatment criteria (1) Cure: After treatment, all the subjective symptoms disappear and the main positive signs disappear; (2)Marked effect: The integral of each subjective symptom is reduced by more than 2 / 3 before treatment, and the integral of positive signs is reduced by more than 2 / 3; (3)Effective: The integral of each subjective symptom is reduced by more than 1 / 3 before treatment, and the integral of positive signs is reduced by more than 1 / 3; (4)Ineffective: The integral of symptoms and signs is reduced by less than 1 / 3 compared with that before treatment, or there is no improvement in symptoms and signs.

[0038] The quantitative integral of positive signs is shown in Table 1. The quantitative integral of clinical symptoms is shown in Table 2.

[0039] Table 1. Quantitative integral table of main signs Table 2. Quantitative integral table of clinical symptoms 4. Treatment results 4.1. Comparison of clinical efficacy between the two groups of patients Comparison of the total effective rates between the two groups ( P <0.05). See Table 3.

[0040] Table 3 Comparison of clinical efficacy between the two groups of patients [n (%)] 4.2. Comparison of quantitative integrals of clinical symptoms between the two groups Before treatment, the two groups were compared ( P >0.05); after treatment, the scores of pharyngeal pain, fever, dry throat, sense of pharyngeal obstruction, foreign body sensation in the pharynx, cough, and expectoration in the treatment group were lower than those in the control group ( P <0.05). See Table 4 and Supplementary Table 4.

[0041] Table 4 Comparison of quantitative integrals of clinical symptoms between the two groups ( ±s, points) Supplementary Table 4 Comparison of quantitative integrals of clinical symptoms between the two groups ( ±s, points) 4.3. Comparison of quantitative integrals of main signs between the two groups Before treatment, the two groups were compared ( P >0.05); after treatment, the scores of tonsil size, tonsil congestion, tonsil secretion, congestion and swelling of the pharyngeal lateral bands, and hyperplasia of lymphoid follicles on the posterior pharyngeal wall in the treatment group were lower than those in the control group ( P <0.05). See Table 5.

[0042] Table 5 Comparison of quantitative integrals of main signs between the two groups ( ±s, points) In summary, the traditional Chinese medicine composition provided by the present invention can reduce the quantitative scores of the main physical signs and clinical symptoms of patients with acute exacerbation of chronic tonsillitis, indicating that it can improve the acute exacerbation of chronic tonsillitis.

[0043] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be encompassed by the present invention.

[0044] In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only contains an independent technical solution. This narrative manner of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A Chinese medicine composition for treating throat diseases, characterized in that: The invention is prepared from the following raw materials by weight: 15-25 parts of whole scorpion, 15-25 parts of borneol and 55-65 parts of lithospermum officinale.

2. The Chinese medicine composition for treating throat diseases according to claim 1, characterized in that: The traditional Chinese medicine composition is prepared from the following raw materials by weight: 20 parts of whole scorpion, 20 parts of borneol and 60 parts of lithospermum officinale.

3. The Chinese medicine composition for treating throat diseases according to claim 1 or 2, characterized in that: The Lithospermum officinale is Lithospermum officinale from Xinjiang.

4. A method for preparing the Chinese medicine composition according to claim 1, characterized in that: The following steps are involved: Weigh scorpion, borneol and lithospermum officinale according to weight and set aside; Crush the dried scorpion and lithospermum officinale, mix with borneol, crush and sieve to obtain the product.

5. The method for preparing the Chinese medicine composition according to claim 4, characterized in that: The drying is carried out at 60° C. for 4 to 8 hours.

6. Use of the Chinese medicine composition according to claim 1 in preparing medicines for treating throat-related diseases.

7. The use according to claim 6, characterized in that The traditional Chinese medicine composition is used for preparing medicine for treating acute and chronic pharyngitis or acute and chronic tonsillitis.

8. A drug for treating throat-related diseases, characterized in that: The medicine uses the Chinese medicine composition according to claim 1 as the only effective active ingredient.

9. The drug according to claim 8, characterized in that The medicine is prepared by mixing the traditional Chinese medicine composition with pharmaceutically acceptable auxiliary materials.

10. The drug according to claim 9, characterized in that The medicine is an external preparation.

Images