High-precision machining process of micro needle head for injection

Abstract

The high-precision machining technology comprises the following steps that solid raw materials are selected for pretreatment, cutting is conducted after treatment to obtain a micro-needle profile, the micro-needle profile is subjected to accurate grinding, specifically, burrs and uneven positions are removed, the head of the micro-needle profile is ground, and an inclination angle with the axial surface is formed; the method comprises the following steps: polishing an obtained micro-needle profile, preparing a surface coating composition, coating the polished micro-needle profile with the composition, measuring the inclination angle of an inclined surface after coating, trimming the inclination angle, carrying out secondary polishing to obtain a micro-needle head, cleaning and disinfecting the obtained micro-needle head, carrying out quality detection, and packaging and delivering the micro-needle head from a warehouse. Compared with the prior art, the high-precision machining process for the micro needle head for injection has the advantages that operation and use are convenient, and the machining precision is guaranteed.

Description

Technical Field

[0001] The present invention relates to the technical field of injection needle processing, and specifically refers to a high-precision processing technology for micro needles for injection. Background Art

[0002] Micro needles for injection are often used in the medical and beauty fields. Currently, the main technologies for manufacturing micro needles include micro injection molding, micro stamping, photolithography, droplet air blowing, electro stretching, and 3D printing technology that has emerged in recent years.

[0003] Among them, micro molding is the most widely used method and can effectively reproduce standardized micro needles. The 3D printing technology provides a high-precision and customizable manufacturing solution, which can manufacture micro needles with complex geometric shapes and structures to meet the needs of individualized and on-demand treatment.

[0004] Although the micro molding process can effectively reproduce standardized micro needles, it has limitations in design complexity and customizability, and it is difficult to control the precision.

[0005] The 3D printing technology has great potential in manufacturing high-precision micro needles, but currently this technology is still in its infancy, and most innovations are still at the research or preclinical level.

[0006] The high-precision processing technology can ensure that parameters such as the size, shape, and penetration depth of the micro needle meet the design requirements, thereby reducing skin damage and pain and improving the safety and effectiveness of treatment. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to overcome the above technical defects and provide a high-precision processing technology for micro needles for injection that is convenient to operate and can ensure processing precision.

[0008] To solve the above technical problem, the technical solution provided by the present invention is: a high-precision processing technology for micro needles for injection, including the following steps: selecting a solid raw material for pretreatment, cutting the pretreated material to obtain a micro needle profile, finely grinding the micro needle profile, including removing burrs and uneven positions, grinding the head of the micro needle profile to form an inclination angle with the axial surface, polishing the obtained micro needle profile, preparing a surface coating composition, coating the polished micro needle profile with the composition, measuring the inclination angle of the inclined surface after coating, trimming the inclination angle and then performing secondary polishing to obtain a micro needle head, cleaning and disinfecting the obtained micro needle head, and performing quality inspection and then packaging and warehousing.

[0009] Preferably, the inclination angle range is 15-20°, and the inclination angle is ground in two times, including rough grinding and fine grinding. When initially grinding, the inclination angle is ground to be 2-3° different from the target degree and then fine grinding is performed to obtain the final inclination angle.

[0010] Preferably, the surface coating composition comprises epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent, and the weight ratio of each component is: epoxy resin: zinc oxide powder: aromatic hydrocarbon solvent = 3-5: 2.8-4.5: 1.5-2.5.

[0011] Preferably, epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent are mixed in proportion to form a mixed solution, the microneedle profile is fed into the mixed solution and completely immersed, and the microneedle profile is taken out for drying and curing after the mixed solution is fully attached to the surface of the microneedle profile.

[0012] Preferably, the microneedle profile is fed into the electrophoresis tank as the cathode, epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent are fed into the electrophoresis solution, and electrophoresis coating is carried out through the action of an electric field. After the coating is completed, the microneedle profile is washed, dried and cured.

[0013] Preferably, the pretreatment of the solid raw material includes cleaning, degreasing and stress relieving treatment, and the solid raw material is cut by laser.

[0014] Preferably, the pretreatment of the solid raw material includes cleaning, degreasing and stress relieving treatment, and the solid raw material is cut by laser.

[0015] Preferably, the pretreatment of the solid raw material includes cleaning, degreasing and stress relieving treatment, and the solid raw material is cut by laser.

[0016] Preferably, the polishing includes preliminary polishing and fine polishing.

[0017] The advantages of the present invention compared with the prior art are as follows: in the invention, by coating the composition on the original needle, two-angle grinding and two polishing are carried out to ensure the accuracy of the microneedle head after production. In this application, the additional composition can reduce the friction with the skin and flesh, and cooperate with the high-precision needle angle to greatly reduce the pain during use, which is easy to promote. Detailed Description of the Invention

[0018] Reference will now be provided in detail to embodiments of the present invention, one or more examples of which are described below. Each example is provided by way of explanation and not limitation of the invention. Indeed, it will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the scope or spirit of the invention. For example, features illustrated or described as part of one embodiment can be used in another embodiment to yield a still further embodiment.

[0019] Except as otherwise shown or indicated in the operating examples, all numbers expressing amounts of ingredients, physical and chemical properties, etc. used in the specification and claims are to be understood as being modified in all instances by the term "about".

[0020] As shown in combination, a high-precision processing technology for injection micro-needles includes the following steps: Select solid raw materials for pretreatment, perform cutting after treatment to obtain micro-needle profiles, perform fine grinding on the micro-needle profiles, including removing burrs and uneven positions, grinding the head of the micro-needle profiles to form an inclination angle with the axial surface, polish the obtained micro-needle profiles, prepare a surface coating composition, coat the polished micro-needle profiles with the composition, measure the inclined surface angle after coating, perform trimming on the inclination angle and then perform secondary polishing to obtain micro-needles, clean and disinfect the obtained micro-needles, and perform quality inspection and then package and store them out of the warehouse.

[0021] When the present invention is specifically implemented, the inclination angle range is 15-20°, and the inclination angle is ground in two times, including rough grinding and fine grinding. When initially grinding, the inclination angle is ground to be 2-3° different from the target degree and then fine grinding is performed to obtain the final inclination angle, through high-precision control of the inclination angle.

[0022] In order to increase the smoothness of the needle, the surface coating composition includes epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent, and the weight ratio of each component is: epoxy resin: zinc oxide powder: aromatic hydrocarbon solvent = 3-5: 2.8-4.5: 1.5-2.5. Take epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent and mix them in proportion to form a mixed solution. Immerse the micro-needle profile completely in the mixed solution, and take out the micro-needle profile for drying and curing after the mixed solution fully adheres to the surface of the micro-needle profile.

[0023] Different from the above embodiments:

[0024] Send the micro-needle profile as the cathode into the electrophoresis tank, send epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent into the electrophoresis solution, perform electrophoresis coating through the action of an electric field, and perform water washing, drying and curing on the micro-needle profile after coating is completed.

[0025] When specifically used:

[0026] The pretreatment of the solid raw materials includes cleaning, degreasing and stress relief treatment. The solid raw materials are cut by laser. The quality inspection includes using electronic scanning to detect the size, shape and surface quality of the micro-needles. The packaging and storage out of the warehouse are carried out in a sterile environment, and the polishing includes preliminary polishing and fine polishing.

[0027] The content not described in detail in this specification belongs to the prior art well-known to those skilled in the art.

[0028] The foregoing has shown and described the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments, and what is described in the above embodiments and the specification is only to illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements fall within the scope of the present invention claimed.

[0029] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the various technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope described in this specification.

[0030] The above description of the present invention and its implementation manners is not restrictive. Generally speaking, if those of ordinary skill in the art are inspired by it and, without departing from the purpose of the present invention, design similar structural modes and embodiments to the technical solution without creative efforts, they should all fall within the protection scope of the present invention.

Claims

1. A high-precision processing technology for microneedles for injection, characterized in that: The method comprises the following steps: selecting solid raw materials for pretreatment, cutting the processed raw materials to obtain microneedle profiles, fine grinding the microneedle profiles, including removing burrs and uneven positions, grinding the heads of the microneedle profiles to form an inclination angle with the axial surface, polishing the obtained microneedle profiles, preparing a surface coating composition, coating the polished microneedle profiles with the composition, measuring the inclination angle of the inclined surface after coating, performing secondary polishing after trimming the inclination angle to obtain microneedle heads, cleaning and disinfecting the obtained microneedle heads, and packaging and shipping out after quality inspection.

2. The high-precision processing technology for microneedles for injection according to claim 1, characterized in that: The inclination angle ranges from 15 to 20 degrees, and the inclination angle is polished twice, including rough polishing and fine polishing. During the initial polishing, the inclination angle is polished to a difference of 2 to 3 degrees from the target degree, and then fine polishing is performed to obtain the final inclination angle.

3. The high-precision processing technology for microneedles for injection according to claim 1, characterized in that: The surface coating composition comprises epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent, wherein the weight ratio of each component is: epoxy resin: zinc oxide powder: aromatic hydrocarbon solvent = 3-5: 2.8-4.5: 1.5-2.

5.

4. The high-precision processing technology for microneedles for injection according to claim 3, characterized in that: Epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent are mixed in proportion to form a mixed liquid, and the microneedle profile is placed in the mixed liquid to be completely immersed. After the mixed liquid is fully attached to the surface of the microneedle profile, the microneedle profile is taken out for drying and curing.

5. The high-precision processing technology for microneedles for injection according to claim 3, characterized in that: The microneedle profile is sent into the electrophoresis tank as the cathode, and epoxy resin, zinc oxide powder and aromatic hydrocarbon solvent are sent into the electrophoresis liquid. Electrophoretic coating is carried out through the action of the electric field. After the coating is completed, the microneedle profile is washed, dried and cured.

6. The high-precision processing technology for microneedles for injection according to claim 1, characterized in that: The pretreatment of the solid raw material includes cleaning, degreasing and stress relief treatment, and the solid raw material is cut by laser.

7. The high-precision processing technology for microneedles for injection according to claim 1, characterized in that: The quality inspection includes inspecting the size, shape and surface quality of the microneedle using electronic scanning.

8. The high-precision processing technology for microneedles for injection according to claim 1, characterized in that: The packaging is carried out in a sterile environment.

9. The high-precision processing technology for microneedles for injection according to claim 1, characterized in that: The polishing includes preliminary polishing and fine polishing.