Broad-spectrum avibacterium paragallinarum protective antigen and application thereof

By using the protective antigen protein prepared by parachyx protein p1, parachyx subunit vaccine and polyclonal antibodies were developed, which solved the problem of insufficient cross-protection and severe stress response of traditional vaccines in preventing and controlling infectious rhinitis in chickens, and achieved efficient protection of the three serotypes parachyx parachyx.

CN120136983AActive Publication Date: 2025-06-13YANGZHOU UNIV
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Patent Information

Application Number
CN202510279285.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-03-11
Publication Date
2025-06-13
Estimated Expiration
2045-03-11

AI Technical Summary

Technical Problem

Traditional whole-bacterial inactivated vaccines have problems with insufficient cross-protection and severe stress response in preventing and controlling infectious rhinitis in chickens. Due to the mismatch between the vaccine strain and the epidemic strain, cases of immune failure occur frequently.

Method used

The broad-spectrum parachyx protective antigen protein was prepared by using parachyx protein p1, and based on this, a subunit vaccine and polyclonal antibodies were developed to provide a 90% protection rate for the three serotypes parachyx parachyx.

Benefits of technology

This method significantly improves the protection of paracarynx, reduces side effects, and effectively prevents infection of paracarynx.

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Abstract

The invention discloses a broad-spectrum avibacterium paragallinarum protective antigen and application thereof, and belongs to the field of prevention and control of poultry infectious diseases. The invention provides an application of an avibacterium paragallinarum protein p1 in preparation of a broad-spectrum avibacterium paragallinarum protective antigen protein. The amino acid sequence of the avibacterium paragallinarum protein p1 is as shown in SEQ ID No. 1. The protective antigen protein has strong immunogenicity and reactogenicity, and a subunit vaccine prepared by using the antigen protein can provide 90% protection rate for avian paragallinarum of three serotypes A, B and C, and can effectively prevent infection of the avian paragallinarum.
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