Intraocular pressure sensor

Abstract

The invention relates to the technical field of medical instruments, in particular to an intraocular pressure sensor which comprises an intraocular pressure sensor body and a support connected with the intraocular pressure sensor body. The support is of a plate-shaped structure. According to the intraocular pressure sensor, the requirement for the stability of the position of the intraocular pressure sensor is high in the intraocular pressure detection process based on optical sensing, the support of a plate-shaped structure is adopted, the comfort degree after implantation is guaranteed, meanwhile, the intraocular pressure sensor body is prevented from moving, the stability of the position of the intraocular pressure sensor body is improved, and the intraocular pressure sensor is suitable for popularization and application. Therefore, frequent adjustment of the shooting angle in the detection process can be avoided, the shooting difficulty is reduced, and the definition of the shot image is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly relates to an intraocular pressure sensor. Background Art

[0002] Glaucoma is one of the three major causes of blindness in the human eye and poses a great harm. High intraocular pressure is considered an important risk factor for the onset of glaucoma. Therefore, intraocular pressure is an important indicator for determining the treatment goal of glaucoma and evaluating the treatment effect and prognosis in clinical practice.

[0003] Currently, the main method for detecting intraocular pressure is to detect the instantaneous intraocular pressure of patients through instruments. The detection instruments mainly include applanation tonometers, air puff tonometers, etc. Among them, the applanation tonometer has a complex measurement process, with disadvantages such as the need for surface anesthesia before measurement, the need to drop fluorescein sodium on the cornea during measurement, and the measurement value being affected by the central corneal thickness. Compared with the applanation tonometer, the air puff tonometer simplifies the process of measuring intraocular pressure and does not require surface anesthesia and fluorescein sodium. However, the air puff tonometer also has many problems, such as the impact air flow causing discomfort in the patient's eyes, the instrument being expensive and not portable.

[0004] In addition, there are currently many studies on micro-implantable intraocular pressure sensors based on different principles. The common features of these studies are: 1. The sensor is separated from the detection device, and the sensing method is non-contact; 2. The area and volume of the sensor are extremely small, ranging from hundreds of micrometers to a few millimeters; 3. The sensor is in contact with the eye structure, attached to the eyeball or implanted inside the eyeball.

[0005] These implantable intraocular pressure sensors can be mainly classified into three types according to the sensing principle: electrical sensing, microfluidic sensing, and optical sensing. Chen et al. designed an intraocular pressure sensor based on the capacitance value being sensitive to pressure, with a contact lens as the carrier. The frequency of the LC oscillator formed by the capacitor and inductor also changes with the change of [parameters not specified in the original text]. The reading device is a large network analyzer. Agaoglu et al. used a microfluidic chip to achieve intraocular pressure detection. The artificial lens integrated with the microfluidic chip was implanted into the eyeball using cataract surgery technology. As the intraocular pressure fluctuates, the position of the liquid-gas interface of the artificial lens generates displacement, and monitoring the position of this interface can obtain the intraocular pressure value. Electrical sensing is limited by the circuit structure and materials, and it is difficult to achieve a size of sub-millimeter level. Moreover, the reading device is large in volume and expensive. Microfluidic sensing is limited by the strict requirements for airtightness and the indirect sensing principle of photographing and reading, which makes miniaturization encounter a bottleneck. The volume of optical sensors is generally smaller than that of electrical sensors and microfluidic sensors. Therefore, it has become the main research direction of implantable sensors.

[0006] In the existing micro pressure sensors based on optical sensing, when measuring intraocular pressure, the incident light needs to satisfy equal inclination interference; for equal inclination interference, the main requirement is that when two interfering light beams are reflected or refracted, the incident angle and the reflection angle (or refraction angle) are equal. In other words, the incident light beam needs to satisfy the requirement of perpendicular incidence to ensure the complete formation of interference fringes.

[0007] Since the intraocular pressure sensor needs to be implanted into the eye, it is extremely easy to move during the detection process; and the movement of the position of the intraocular pressure sensor will cause the incident light to not meet the detection requirement of perpendicular incidence, making the detection of intraocular pressure more difficult. Summary of the Invention

[0008] In order to solve the problem of the relatively large detection difficulty of the existing intraocular pressure sensors based on optical sensing, the present invention provides an intraocular pressure sensor. By introducing a bracket with a plate-like structure, the contact area between the intraocular pressure sensor and the interior of the eye is increased, and the movement of the intraocular pressure sensor is avoided, thereby reducing the detection difficulty of intraocular pressure while improving the clarity of the detection image, and solving the problem of the relatively large detection difficulty of the existing intraocular pressure sensors based on optical sensing.

[0009] The technical solution adopted by the present invention to solve its technical problems is: An intraocular pressure sensor includes an intraocular pressure sensor body and a bracket connected to the intraocular pressure sensor body; the bracket has a plate-like structure.

[0010] Optionally, a Fabry microcavity is provided on the intraocular pressure sensor body.

[0011] Optionally, the bracket includes a mounting end and a fixed end connected to the mounting end; the mounting end is connected to the intraocular pressure sensor body.

[0012] Optionally, the fixed end has an arc-like structure.

[0013] Optionally, the fixed end includes a wide section, a tapered section, and a narrow section connected in sequence; the widths of the wide section, the tapered section, and the narrow section decrease in sequence.

[0014] Optionally, the length ratio of the wide section, the tapered section, and the narrow section is (1.4 - 1.7):(1.1 - 1.4):(0.7 - 1).

[0015] Optionally, an anti-slip structure is provided on the outer side of the narrow section.

[0016] Optionally, the anti-slip structure is a convex structure extending outward from the outer side of the narrow section.

[0017] Optionally, the cross-section of the convex structure is triangular.

[0018] Optionally, a drainage groove is provided on the bracket.

[0019] Optionally, the drainage groove includes a first groove-like structure longitudinally distributed along the bracket.

[0020] Optionally, the drainage groove further includes a second groove-like structure obliquely distributed on the wide section; the second groove-like structure is communicated with the first groove-like structure.

[0021] The beneficial effects of the present invention are as follows: For the intraocular pressure sensor provided by the present invention, the stability of the position of the intraocular pressure sensor is required to be relatively high during the intraocular pressure detection process based on optical sensing. The present invention adopts a bracket with a plate-like structure, which can avoid the movement of the intraocular pressure sensor body while ensuring the comfort after implantation, improve the stability of its position, and further avoid frequently adjusting the shooting angle during the detection process, reduce the shooting difficulty, and improve the clarity of the captured image. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The present invention will be further described below with reference to the drawings and embodiments.

[0023] Figure 1 is an exploded view of the intraocular pressure sensor in the present invention.

[0024] In the figure: 1 - intraocular pressure sensor body; 11 - Fabry microcavity; 2 - bracket; 21 - mounting end; 22 - fixed end; 221 - wide section; 222 - tapered section; 223 - narrow section; 2231 - convex structure; 23 - drainage groove; 231 - first groove-like structure; 232 - second groove-like structure. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] The present invention will now be described in further detail. The embodiments described below are exemplary and are intended to explain the present invention and should not be construed as limiting the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0026] To make the above objects, features, and advantages of the present invention more obvious and understandable, the following detailed description of the specific embodiments of the present invention will be made with reference to the drawings.

[0027] To solve the problem of the relatively large detection difficulty of the intraocular pressure sensor based on optical sensing in the prior art, the present invention provides an intraocular pressure sensor. Referring to Figure 1 as shown, the intraocular pressure sensor includes an intraocular pressure sensor body 1, the intraocular pressure sensor body 1 is a MEMS sensor; and a bracket 2 connected to the intraocular pressure sensor body 1; the bracket 2 is a plate-like structure.

[0028] Most of the existing brackets for fixing intraocular implants are cylindrical structures; since the intraocular pressure sensor provided by the present invention requires a high stability of the position during the detection process, a slight movement of the position will cause the incident light beam to not be vertically incident, and it is necessary to readjust the shooting angle of the shooting element. Therefore, the stability requirement for the position of the intraocular pressure sensor is relatively high; after the intraocular pressure sensor is implanted into the eye, due to the presence of liquid in the implantation environment, it is extremely easy to move in the eye; in order to avoid the movement of the intraocular pressure sensor position during the detection process, the present invention preferably uses the bracket 2 as a plate-like structure. On the one hand, it increases the contact area between the bracket 2 and the inside of the eye and reduces the risk of movement; on the other hand, after the plate-like structure bracket 2 is implanted into the eye, the liquid between the plate-like structure and the eyeball is reduced, so that the plate-like structure can be "adsorbed" on the eyeball, thereby avoiding the movement of the intraocular pressure sensor body 1.

[0029] In the present invention, the material of the bracket 2 can be a material suitable for medical implantation such as titanium alloy.

[0030] For the intraocular pressure sensor provided by the present invention, the stability requirement for the position of the intraocular pressure sensor during the intraocular pressure detection process based on optical sensing is relatively high. The present invention uses the plate-like structure bracket 2 to avoid the movement of the intraocular pressure sensor body 1 while ensuring the comfort after implantation, improve its position stability, and further avoid frequent adjustment of the shooting angle during the detection process, reduce the shooting difficulty, and improve the clarity of the captured image.

[0031] The intraocular pressure sensor provided by the present invention can be implanted into the eye by injection, and the surgical trauma is significantly reduced; the intraocular pressure sensor provided by the present invention through a breakthrough design and can be implanted into the eye by minimally invasive injection can continuously monitor the intraocular pressure all day long without electronic components and electromagnetic energy supply, and the intraocular pressure measurement accuracy reaches ±1 mmHg.

[0032] The intraocular pressure sensor body 11 in the present invention can be any sensor for measuring intraocular pressure based on optical sensing; specifically, the present invention preferably provides a Fabry-Perot microcavity 11 on the intraocular pressure sensor body 1. During use, the intraocular pressure sensor is implanted into the anterior chamber of the eyeball, and the outer surface of the Fabry-Perot microcavity 11 contacts the intraocular liquid to sense the change of intraocular pressure; when the intraocular pressure increases, the Fabry-Perot microcavity 11 deforms, resulting in a change in the optical path of the reflected light, a change in the generated interference pattern, and a bending of the interference fringes. By accurately identifying, segmenting, and extracting the interference fringe region contained in the interference pattern, the skeleton of the fringe is extracted after binarization, and the order of each fringe is marked, and then the central deflection of the film of the Fabry-Perot microcavity 11 after being pressed is calculated; the central deflection of the film of the Fabry-Perot microcavity 11 corresponds one-to-one to the pressure value of the Fabry-Perot microcavity film calibrated by the calibration device, realizing the conversion of the photo of the captured image containing interference fringes into a pressure value, and further being able to obtain the intraocular pressure according to the change of the interference pattern.

[0033] The intraocular pressure sensor provided by the present invention can establish the functional relationship between the deflection of the Fabry microcavity 11 in the central area of the sensor and the intraocular pressure based on the change in the interference fringe spacing of the sensor caused by the change in intraocular pressure. Through the advanced M-net neural network training and sparse attention Transformer image restoration algorithm integrated in the mobile phone APP, it automatically focuses, identifies, and crops the interference fringe area of the sensor and performs real-time intraocular pressure demodulation, enabling patients to self-test intraocular pressure at home with a mobile phone, without relying on the signal transmission of electromagnetic energy supply, effectively avoiding signal loss caused by external factors.

[0034] The intraocular pressure sensor provided by the present invention has stronger compatibility and universality, can be compatible and used in supporting with any existing ophthalmic implant device, and helps to further explore the feasibility of the clinical new technology of integrated glaucoma monitoring and diagnosis and treatment.

[0035] To facilitate the fixation of the intraocular pressure sensor body 1, the present invention preferably provides that the bracket 2 includes a mounting end 21 and a fixing end 22 connected to the mounting end 21; the mounting end 21 is connected to the intraocular pressure sensor body 1; to ensure the comfort after implantation, the present invention preferably provides that the mounting end 21 is a plate-like structure, and the size of the mounting end 21 is determined according to the size of the intraocular pressure sensor body 1.

[0036] The intraocular pressure sensor body 1 and the mounting end 21 in the present invention can be connected by means of high-temperature bonding, bonding with compatible materials, etc.

[0037] Since the eyeball has a certain curvature, to improve the fitting degree of the bracket 2 with the eyeball, so that the implanted bracket 2 can be better "adsorbed" after implantation, while improving the stability of the intraocular pressure sensor body 1 and the comfort of the patient, the present invention preferably provides that the fixing end 22 is an arc-shaped structure, and the curvature of the arc-shaped structure is determined according to the curvature of the eyeball.

[0038] To further improve the comfort while ensuring the stability of the intraocular pressure sensor body 1, the present invention preferably provides that the fixing end 22 includes a wide section 221, a gradual change section 222, and a narrow section 223 connected in sequence; the widths of the wide section 221, the gradual change section 222, and the narrow section 223 decrease in sequence.

[0039] It should be noted that in the bracket 2 of the present invention, in the length direction of the distribution direction of the wide section 221, the gradual change section 222, and the narrow section 223, in the plane of the plate-like structure of the bracket 2, the direction perpendicular to this length direction is the width direction.

[0040] Specifically, the present invention preferably provides that the wide section 221 is a plate-like structure with a rectangular cross-section to ensure the contact area between the bracket 2 and the eyeball; preferably, the width of the gradual change section 222 decreases in sequence, the width of the end connected to the wide section 221 is the same as the width of the wide section 221, and the width of the end connected to the narrow section 223 is the same as the width of the narrow section 223.

[0041] To balance comfort and the stability of the position of the intraocular pressure sensor body 1, the present invention preferably sets the length ratio of the wide section 221, the tapered section 222, and the narrow section 223 to (1.4 - 1.7):(1.1 - 1.4):(0.7 - 1).

[0042] To further improve the stability of the position of the intraocular pressure sensor body 1, the present invention preferably provides an anti-slip structure on the outer side of the narrow section 223.

[0043] Specifically, the present invention preferably sets the anti-slip structure as a convex structure 2231 extending towards the outer side of the narrow section 223, and further preferably sets the cross-section of the convex structure 2231 as a triangle, so that the bracket 2 is more easily adsorbed to the eyeball.

[0044] To balance the stability of the position of the intraocular pressure sensor body 1 and comfort, the present invention further preferably sets the number of the convex structures 2231 to at least two groups, each group including two convexes of the same size symmetrically arranged on both sides of the narrow section 223; and, the size of the convexes gradually decreases along the direction away from the tapered section 222.

[0045] Existing intraocular pressure sensors usually only have the function of intraocular pressure detection and cannot achieve drainage; when the intraocular pressure is high, a corresponding drainage device needs to be introduced to achieve the therapeutic effect; based on this, the present invention preferably provides a drainage groove 23 on the bracket 2, so as to diffuse the aqueous humor to the surrounding tissues of the eye through the drainage groove 23, so that the intraocular pressure sensor can combine the functions of intraocular pressure detection and drainage, and thus can achieve intraocular pressure detection and drainage by one implantation without increasing the number of implantations, the surgically induced injury, and the pain of the patient.

[0046] The drainage groove 23 includes a groove-shaped structure longitudinally distributed along the bracket 2 and sequentially penetrating through the installation end 21 and the fixed end 22, denoted as the first groove-shaped structure 231; to further improve the drainage effect, the drainage groove 23 further includes a second groove-shaped structure 232 obliquely distributed on the wide section 221, and the second groove-shaped structure 232 is communicated with the first groove-shaped structure 231.

[0047] Enlightened by the ideal embodiments of the present invention described above, through the above description, relevant staff can completely make various changes and modifications without departing from the technical idea of the present invention. The technical scope of the present invention is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. An intraocular pressure sensor, characterized in that: It comprises an intraocular pressure sensor body (1) and a bracket (2) connected to the intraocular pressure sensor body (1); the bracket (2) is a plate-shaped structure.

2. The intraocular pressure sensor according to claim 1, wherein: The intraocular pressure sensor body (1) is provided with a Fabry-Perot microcavity (11).

3. The intraocular pressure sensor according to claim 1 or 2, characterized in that: The bracket (2) comprises a mounting end (21) and a fixing end (22) connected to the mounting end (21); the mounting end (21) is connected to the intraocular pressure sensor body (1).

4. The intraocular pressure sensor according to claim 3, characterized in that: The fixed end (22) is an arc-shaped structure.

5. The intraocular pressure sensor according to claim 3, characterized in that: The fixed end (22) comprises a wide section (221), a gradual section (222), and a narrow section (223) which are connected in sequence; the widths of the wide section (221), the gradual section (222), and the narrow section (223) decrease in sequence.

6. The intraocular pressure sensor according to claim 5, characterized in that: The length ratio of the wide section (221), the gradient section (222), and the narrow section (223) is (1.4-1.7): (1.1-1.4): (0.7-1).

7. The intraocular pressure sensor according to claim 6, characterized in that: An anti-slip structure is provided on the outer side of the narrow section (223).

8. The intraocular pressure sensor according to claim 7, characterized in that: The anti-slip structure is a protruding structure (2231) extending toward the outside of the narrow section (223).

9. The intraocular pressure sensor according to claim 8, characterized in that: The cross section of the protruding structure (2231) is triangular.

10. The intraocular pressure sensor according to claim 5, characterized in that: The support (2) is provided with a drainage groove (23).

11. The intraocular pressure sensor according to claim 10, characterized in that: The drainage groove (23) comprises a first groove-shaped structure (231) distributed longitudinally along the bracket (2).

12. The intraocular pressure sensor according to claim 11, characterized in that: The drainage groove (23) further comprises a second groove-like structure (232) obliquely distributed on the wide section (221); the second groove-like structure (232) is connected to the first groove-like structure (231).

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